---
OA_type: closed access
_id: '21153'
abstract:
- lang: eng
  text: "Curcumin possess anti-inflammatory activity. In this study, the binding of
    curcumin with PLA2 was studied using X-ray crystallography. Since the electron
    density found at the active site did not match with curcumin, 2-methoxycyclohexa-2-5-diene-1,4-dione
    (MCW) (the photodegraded product of curcumin) was fitted in the unexplained electron
    density. To understand the binding mode of actual curcumin, molecular docking
    study was carried out. The crystallographic and docked structures were superimposed
    with respect to the ligand position and it was found that curcumin was binding
    in the hydrophobic cavity of PLA2 with a binding energy of−16.81 Kcal/mol. The
    binding mode was of such a nature that it prevented the entry of the substrate
    to the hydrophobic active site. This study indicates that curcumin can act as
    an inhibitor of PLA2.\r\n\r\nAn animated Interactive 3D Complement (I3DC) is available
    in Proteopedia at http://proteopedia.org/w/Journal:FLS:1."
article_processing_charge: No
article_type: original
author:
- first_name: K. V.
  full_name: Dileep, K. V.
  last_name: Dileep
- first_name: I.
  full_name: Tintu, I.
  last_name: Tintu
- first_name: Pradeep K
  full_name: Mandal, Pradeep K
  id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
  last_name: Mandal
  orcid: 0000-0001-5996-956X
- first_name: P.
  full_name: Karthe, P.
  last_name: Karthe
- first_name: M.
  full_name: Haridas, M.
  last_name: Haridas
- first_name: C.
  full_name: Sadasivan, C.
  last_name: Sadasivan
citation:
  ama: Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C. Crystal structure
    of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione.
    <i>Frontiers in Life Science</i>. 2012;5(3-4):135-139. doi:<a href="https://doi.org/10.1080/21553769.2012.689262">10.1080/21553769.2012.689262</a>
  apa: Dileep, K. V., Tintu, I., Mandal, P. K., Karthe, P., Haridas, M., &#38; Sadasivan,
    C. (2012). Crystal structure of porcine pancreatic phospholipase A2 in complex
    with 2-methoxycyclohexa-2-5-diene-1,4-dione. <i>Frontiers in Life Science</i>.
    Informa UK Limited. <a href="https://doi.org/10.1080/21553769.2012.689262">https://doi.org/10.1080/21553769.2012.689262</a>
  chicago: Dileep, K. V., I. Tintu, Pradeep K Mandal, P. Karthe, M. Haridas, and C.
    Sadasivan. “Crystal Structure of Porcine Pancreatic Phospholipase A2 in Complex
    with 2-Methoxycyclohexa-2-5-Diene-1,4-Dione.” <i>Frontiers in Life Science</i>.
    Informa UK Limited, 2012. <a href="https://doi.org/10.1080/21553769.2012.689262">https://doi.org/10.1080/21553769.2012.689262</a>.
  ieee: K. V. Dileep, I. Tintu, P. K. Mandal, P. Karthe, M. Haridas, and C. Sadasivan,
    “Crystal structure of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione,”
    <i>Frontiers in Life Science</i>, vol. 5, no. 3–4. Informa UK Limited, pp. 135–139,
    2012.
  ista: Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C. 2012. Crystal
    structure of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione.
    Frontiers in Life Science. 5(3–4), 135–139.
  mla: Dileep, K. V., et al. “Crystal Structure of Porcine Pancreatic Phospholipase
    A2 in Complex with 2-Methoxycyclohexa-2-5-Diene-1,4-Dione.” <i>Frontiers in Life
    Science</i>, vol. 5, no. 3–4, Informa UK Limited, 2012, pp. 135–39, doi:<a href="https://doi.org/10.1080/21553769.2012.689262">10.1080/21553769.2012.689262</a>.
  short: K.V. Dileep, I. Tintu, P.K. Mandal, P. Karthe, M. Haridas, C. Sadasivan,
    Frontiers in Life Science 5 (2012) 135–139.
date_created: 2026-02-06T12:17:45Z
date_published: 2012-08-06T00:00:00Z
date_updated: 2026-02-20T08:07:19Z
day: '06'
doi: 10.1080/21553769.2012.689262
extern: '1'
has_accepted_license: '1'
intvolume: '         5'
issue: 3-4
language:
- iso: eng
month: '08'
oa_version: None
page: 135-139
publication: Frontiers in Life Science
publication_identifier:
  issn:
  - 2155-3769
  - 2155-3777
publication_status: published
publisher: Informa UK Limited
quality_controlled: '1'
status: public
title: Crystal structure of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2012'
...