---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21899'
abstract:
- lang: eng
text: Cell extrusion is an essential mechanism for controlling cell density in epithelial
tissues. Another essential element of epithelia is curvature, which is required
to achieve complex shapes, like in the lung or intestine. Here, we introduce a
three-dimensional bubbly vertex model to study the interplay between extrusion
and curvature. We find a generic cellular bulging instability at topological defects,
which is much stronger than for standard vertex models. Analyzing cell shapes
in three-dimensional imaging data of spherical mouse colon organoids, we infer
that pentagonal cells have an increased basal interfacial tension, suggesting
that cells at topological defects react to the different force conditions. Using
the bubbly vertex model, we show that such basal tensions stabilize against the
predicted instability and result in better cell shape control than tissue-scale
mechanisms such as lumen pressure and spontaneous curvature. Our theory suggests
that epithelial curvature naturally leads to bulged and extrusionlike cell shapes
because the interfacial curvature of individual cells at the defects strongly
amplifies buckling effected by tissue-scale topological defects in elastic sheets.
Our results highlight the complex interplay of forces across scales in three-dimensional
tissue organization.
acknowledgement: O. M. D., M. B., and U.S. S. acknowledge support from the Max Planck
School Matter to Life, with funding by the German Federal Ministry of Education
and Research (BMBF), the Dieter Schwarz Foundation, and the Max Planck Society.
M. B. and U.S. S. acknowledge support from the cluster of excellence 3DMM2O (EXC
2082/1-390761711 and EXC 2082/2-390761711) funded by the Deutsche Forschungsgemeinschaft
(DFG, German Research Foundation). The authors acknowledge the data storage service
SDS@hd supported by the Ministry of Science, Research and the Arts Baden-Württemberg
(MWK) and the DFG through Grant No. INST 35/1503-1 FUGG. For the publication fee
we acknowledge financial support by Heidelberg University. O. M. D. thanks Edouard
Hannezo for valuable discussions. U.S. S. is a member of the Interdisciplinary Center
for Scientific Computing (IWR) at Heidelberg.
article_number: '021023'
article_processing_charge: Yes
article_type: original
author:
- first_name: Oliver M
full_name: Drozdowski, Oliver M
id: cd4ed792-b872-11ef-bb90-b7b3a3f62f75
last_name: Drozdowski
- first_name: Büşra
full_name: "Kocameşe-Tamgac\U0001D6A4, Büşra"
last_name: "Kocameşe-Tamgac\U0001D6A4"
- first_name: Kim E.
full_name: Boonekamp, Kim E.
last_name: Boonekamp
- first_name: Michael
full_name: Boutros, Michael
last_name: Boutros
- first_name: Ulrich S.
full_name: Schwarz, Ulrich S.
last_name: Schwarz
citation:
ama: "Drozdowski OM, Kocameşe-Tamgac\U0001D6A4 B, Boonekamp KE, Boutros M, Schwarz
US. Cell bulging and extrusion in a three-dimensional bubbly vertex model for
curved epithelial sheets. Physical Review X. 2026;16(2). doi:10.1103/x82g-cq7n"
apa: "Drozdowski, O. M., Kocameşe-Tamgac\U0001D6A4, B., Boonekamp, K. E., Boutros,
M., & Schwarz, U. S. (2026). Cell bulging and extrusion in a three-dimensional
bubbly vertex model for curved epithelial sheets. Physical Review X. American
Physical Society. https://doi.org/10.1103/x82g-cq7n"
chicago: "Drozdowski, Oliver M, Büşra Kocameşe-Tamgac\U0001D6A4, Kim E. Boonekamp,
Michael Boutros, and Ulrich S. Schwarz. “Cell Bulging and Extrusion in a Three-Dimensional
Bubbly Vertex Model for Curved Epithelial Sheets.” Physical Review X. American
Physical Society, 2026. https://doi.org/10.1103/x82g-cq7n."
ieee: "O. M. Drozdowski, B. Kocameşe-Tamgac\U0001D6A4, K. E. Boonekamp, M. Boutros,
and U. S. Schwarz, “Cell bulging and extrusion in a three-dimensional bubbly vertex
model for curved epithelial sheets,” Physical Review X, vol. 16, no. 2.
American Physical Society, 2026."
ista: "Drozdowski OM, Kocameşe-Tamgac\U0001D6A4 B, Boonekamp KE, Boutros M, Schwarz
US. 2026. Cell bulging and extrusion in a three-dimensional bubbly vertex model
for curved epithelial sheets. Physical Review X. 16(2), 021023."
mla: Drozdowski, Oliver M., et al. “Cell Bulging and Extrusion in a Three-Dimensional
Bubbly Vertex Model for Curved Epithelial Sheets.” Physical Review X, vol.
16, no. 2, 021023, American Physical Society, 2026, doi:10.1103/x82g-cq7n.
short: "O.M. Drozdowski, B. Kocameşe-Tamgac\U0001D6A4, K.E. Boonekamp, M. Boutros,
U.S. Schwarz, Physical Review X 16 (2026)."
date_created: 2026-05-20T14:35:57Z
date_published: 2026-04-30T00:00:00Z
date_updated: 2026-05-21T06:08:11Z
day: '30'
ddc:
- '530'
department:
- _id: EdHa
doi: 10.1103/x82g-cq7n
file:
- access_level: open_access
checksum: a90e905968648ac4425c256de901e9c3
content_type: application/pdf
creator: dernst
date_created: 2026-05-21T06:05:49Z
date_updated: 2026-05-21T06:05:49Z
file_id: '21901'
file_name: 2026_PhysicalReviewX_Drozdowski.pdf
file_size: 5603164
relation: main_file
success: 1
file_date_updated: 2026-05-21T06:05:49Z
fulldoi: https://doi.org/10.1103/x82g-cq7n
has_accepted_license: '1'
intvolume: ' 16'
issue: '2'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '04'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
issn:
- 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell bulging and extrusion in a three-dimensional bubbly vertex model for curved
epithelial sheets
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22288'
abstract:
- lang: eng
text: Soft solids and their surface deformations control the response of many natural
and artificial systems. Yet, their underlying properties are vigorously debated,
particularly for polymer networks. While molecular-scale theories predict no interfacial
changes with macroscopic deformation, multiple experiments suggest otherwise.
To settle this issue, we measure displacement fields near the interface of a silicone
gel, in the limit of small deformations. We discover an unexpected multiscale
response. The shear modulus decreases smoothly by half with 20 μm of the interface.
At the same time we observe a surface excess elasticity, that depends on history
and outer medium composition. These results reveal the fundamentally multiscale
nature of polymeric surfaces, and call for further experimental and theoretical
investigations into the basic understanding of soft solid interfaces.
acknowledgement: The authors thank Katharine Jensen, Stefanie Heyden, Thomas Salez,
Francesco Stellacci, Denis Bartolo, Francesco Picella, Hélène Delanoë-Ayari, Mathieu
Leocmach, Antoine Bérut, Cécile Cottin-Bizonne, Anne-Laure Biance, and Oriane Talabart
for useful discussions. We also thank the reviewers for excellent suggestions that
substantively improved the manuscript.
article_number: '021063'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Nicolas
full_name: Bain, Nicolas
last_name: Bain
- first_name: Lawrence A.
full_name: Wilen, Lawrence A.
last_name: Wilen
- first_name: Dominic
full_name: Gerber, Dominic
last_name: Gerber
- first_name: Mengjie
full_name: Zu, Mengjie
id: 26dd9e7c-e86a-11eb-a854-82ac731c9ae2
last_name: Zu
- first_name: Carl Peter
full_name: Goodrich, Carl Peter
id: EB352CD2-F68A-11E9-89C5-A432E6697425
last_name: Goodrich
orcid: 0000-0002-1307-5074
- first_name: Senthilkumar
full_name: Duraivel, Senthilkumar
last_name: Duraivel
- first_name: Kaarthik
full_name: Varma, Kaarthik
last_name: Varma
- first_name: Harsha
full_name: Koganti, Harsha
last_name: Koganti
- first_name: Robert W.
full_name: Style, Robert W.
last_name: Style
- first_name: Eric R.
full_name: Dufresne, Eric R.
last_name: Dufresne
citation:
ama: Bain N, Wilen LA, Gerber D, et al. Multiscale interfacial mechanics of soft
solids. Physical Review X. 2026;16(2). doi:10.1103/8msx-l8s7
apa: Bain, N., Wilen, L. A., Gerber, D., Zu, M., Goodrich, C. P., Duraivel, S.,
… Dufresne, E. R. (2026). Multiscale interfacial mechanics of soft solids. Physical
Review X. American Physical Society. https://doi.org/10.1103/8msx-l8s7
chicago: Bain, Nicolas, Lawrence A. Wilen, Dominic Gerber, Mengjie Zu, Carl Peter
Goodrich, Senthilkumar Duraivel, Kaarthik Varma, Harsha Koganti, Robert W. Style,
and Eric R. Dufresne. “Multiscale Interfacial Mechanics of Soft Solids.” Physical
Review X. American Physical Society, 2026. https://doi.org/10.1103/8msx-l8s7.
ieee: N. Bain et al., “Multiscale interfacial mechanics of soft solids,”
Physical Review X, vol. 16, no. 2. American Physical Society, 2026.
ista: Bain N, Wilen LA, Gerber D, Zu M, Goodrich CP, Duraivel S, Varma K, Koganti
H, Style RW, Dufresne ER. 2026. Multiscale interfacial mechanics of soft solids.
Physical Review X. 16(2), 021063.
mla: Bain, Nicolas, et al. “Multiscale Interfacial Mechanics of Soft Solids.” Physical
Review X, vol. 16, no. 2, 021063, American Physical Society, 2026, doi:10.1103/8msx-l8s7.
short: N. Bain, L.A. Wilen, D. Gerber, M. Zu, C.P. Goodrich, S. Duraivel, K. Varma,
H. Koganti, R.W. Style, E.R. Dufresne, Physical Review X 16 (2026).
das_tickbox: '1'
dataavailabilitystatement: The data that support the findings of this article are
openly available https://github.com/nicobain/Multiscale_interfacial_mechanics_soft_solids_data
date_created: 2026-07-13T09:40:54Z
date_published: 2026-06-30T00:00:00Z
date_updated: 2026-07-13T11:17:51Z
day: '30'
ddc:
- '530'
department:
- _id: CaGo
doi: 10.1103/8msx-l8s7
external_id:
arxiv:
- '2410.09158'
file:
- access_level: open_access
checksum: 47354f40981223fb0c9afe292f16ead1
content_type: application/pdf
creator: dernst
date_created: 2026-07-13T11:16:47Z
date_updated: 2026-07-13T11:16:47Z
file_id: '22309'
file_name: 2026_PhysicalReviewX_Bain.pdf
file_size: 4367284
relation: main_file
success: 1
file_date_updated: 2026-07-13T11:16:47Z
fulldoi: https://doi.org/10.1103/8msx-l8s7
has_accepted_license: '1'
intvolume: ' 16'
issue: '2'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
issn:
- 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Multiscale interfacial mechanics of soft solids
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22755'
abstract:
- lang: eng
text: The eigenstate thermalization hypothesis (ETH) posits how isolated quantum
many-body systems thermalize, assuming that individual eigenstates at the same
energy density have identical expectation values of local observables in the limit
of large systems. While the ETH apparently holds across a wide range of interacting
quantum systems, in this work, we show that it may require generalization in the
presence of thermal first-order phase transitions. We introduce a class of all-to-all
spin models, featuring first-order thermal phase transitions that stem from two
distinct local maxima of entropy (two mean-field solutions that we dub “branches”)
that exchange dominance in the many-body density of states as the energy is varied.
We argue that, for energies in the vicinity of the thermal phase transition, eigenstate
expectation values do not need to converge to the same thermal value. The system
has a regime with coexistence of two classes of eigenstates corresponding to the
two branches with distinct expectation values at the same energy density and another
regime with Schrödinger-cat-like eigenstates that are interbranch superpositions;
these two regimes are separated by an eigenstate phase transition. We propose
a more general form of the ETH , support our results by semiclassical calculations
and an exact diagonalization study of a microscopic spin model, and argue that
the structure of eigenstates in the vicinity of thermal first-order phase transitions
can be experimentally probed via nonequilibrium dynamics.
acknowledgement: A. A. acknowledges discussions and prior collaboration on related
topics with Anatoly Dymarsky. M. S. acknowledges Ashwin Vishwanath for introducing
him to the idea of thermal first-order phase transitions in quantum systems. This
research was supported in part by Grant No. NSF PHY-2309135 to the Kavli Institute
for Theoretical Physics (KITP) and by the Erwin Schrödinger International Institute
for Mathematics and Physics (ESI). O. K. D. acknowledges support from the NSF through
a grant for ITAMP at Harvard University. D. A. H. was supported in part by NSF QLCI
Grant No. OMA-2120757.
article_number: '031042'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
- first_name: Alexander
full_name: Avdoshkin, Alexander
last_name: Avdoshkin
- first_name: Oriana K.
full_name: Diessel, Oriana K.
last_name: Diessel
- first_name: David A.
full_name: Huse, David A.
last_name: Huse
citation:
ama: Serbyn M, Avdoshkin A, Diessel OK, Huse DA. Eigenstate thermalization in thermal
first-order phase transitions. Physical Review X. 2026;16(3). doi:10.1103/4zs8-7kf4
apa: Serbyn, M., Avdoshkin, A., Diessel, O. K., & Huse, D. A. (2026). Eigenstate
thermalization in thermal first-order phase transitions. Physical Review X.
American Physical Society. https://doi.org/10.1103/4zs8-7kf4
chicago: Serbyn, Maksym, Alexander Avdoshkin, Oriana K. Diessel, and David A. Huse.
“Eigenstate Thermalization in Thermal First-Order Phase Transitions.” Physical
Review X. American Physical Society, 2026. https://doi.org/10.1103/4zs8-7kf4.
ieee: M. Serbyn, A. Avdoshkin, O. K. Diessel, and D. A. Huse, “Eigenstate thermalization
in thermal first-order phase transitions,” Physical Review X, vol. 16,
no. 3. American Physical Society, 2026.
ista: Serbyn M, Avdoshkin A, Diessel OK, Huse DA. 2026. Eigenstate thermalization
in thermal first-order phase transitions. Physical Review X. 16(3), 031042.
mla: Serbyn, Maksym, et al. “Eigenstate Thermalization in Thermal First-Order Phase
Transitions.” Physical Review X, vol. 16, no. 3, 031042, American Physical
Society, 2026, doi:10.1103/4zs8-7kf4.
short: M. Serbyn, A. Avdoshkin, O.K. Diessel, D.A. Huse, Physical Review X 16 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: There are no publicly available research data or software
supporting this manuscript. Requests for further information or data should be sent
to the authors.
date_created: 2026-08-24T06:57:25Z
date_published: 2026-08-18T00:00:00Z
date_updated: 2026-09-09T07:01:47Z
day: '18'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/4zs8-7kf4
external_id:
arxiv:
- '2601.08347'
file:
- access_level: open_access
checksum: 8bf0d88f17783dc1e6bf4c754534d734
content_type: application/pdf
creator: dernst
date_created: 2026-09-09T07:00:24Z
date_updated: 2026-09-09T07:00:24Z
file_id: '22862'
file_name: 2026_PhysicalReviewX_Serbyn.pdf
file_size: 2537492
relation: main_file
success: 1
file_date_updated: 2026-09-09T07:00:24Z
fulldoi: https://doi.org/10.1103/4zs8-7kf4
has_accepted_license: '1'
intvolume: ' 16'
issue: '3'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
issn:
- 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
researchdata_availability: upon request
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Eigenstate thermalization in thermal first-order phase transitions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '22213'
abstract:
- lang: eng
text: Unlike biological active matter that constantly adapt to their environment,
the motors of synthetic active particles are typically agnostic to their surroundings
and merely operate at constant force. Here, we design colloidal active rods capable
of modulating their inner activity in response to crowding, thereby enforcing
a primitive form of quorum sensing interactions. Through experiments, simulations,
and theory we elucidate the impact of these interactions on the phase behavior
of isotropic active matter. We demonstrate that, when conditioned to density,
motility regulation can either lead to an absorbing phase transition, where all
particles freeze their dynamics, or to atypical phase separation, where flat interfaces
supporting a net pressure drop are in mechanical equilibrium. Fully active and
fully arrested particles can then form heterogeneous patterns ruled by the competition
between quorum sensing and mechanical interactions. Beyond the specifics of motile
colloids, we expect our findings to apply broadly to adaptive active matter assembled
from living or synthetic units.
article_number: '031050'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Thibault
full_name: Lefranc, Thibault
last_name: Lefranc
- first_name: Alberto
full_name: Dinelli, Alberto
last_name: Dinelli
- first_name: Carla
full_name: Fernández-Rico, Carla
id: 492def71-6250-11f0-b278-d41dbd241b62
last_name: Fernández-Rico
- first_name: Roel P. A.
full_name: Dullens, Roel P. A.
last_name: Dullens
- first_name: Julien
full_name: Tailleur, Julien
last_name: Tailleur
- first_name: Denis
full_name: Bartolo, Denis
last_name: Bartolo
citation:
ama: Lefranc T, Dinelli A, Fernández-Rico C, Dullens RPA, Tailleur J, Bartolo D.
Synthetic quorum sensing and absorbing phase transitions in colloidal active matter.
Physical Review X. 2025;15(3). doi:10.1103/8csn-71jk
apa: Lefranc, T., Dinelli, A., Fernández-Rico, C., Dullens, R. P. A., Tailleur,
J., & Bartolo, D. (2025). Synthetic quorum sensing and absorbing phase transitions
in colloidal active matter. Physical Review X. American Physical Society.
https://doi.org/10.1103/8csn-71jk
chicago: Lefranc, Thibault, Alberto Dinelli, Carla Fernández-Rico, Roel P. A. Dullens,
Julien Tailleur, and Denis Bartolo. “Synthetic Quorum Sensing and Absorbing Phase
Transitions in Colloidal Active Matter.” Physical Review X. American Physical
Society, 2025. https://doi.org/10.1103/8csn-71jk.
ieee: T. Lefranc, A. Dinelli, C. Fernández-Rico, R. P. A. Dullens, J. Tailleur,
and D. Bartolo, “Synthetic quorum sensing and absorbing phase transitions in colloidal
active matter,” Physical Review X, vol. 15, no. 3. American Physical Society,
2025.
ista: Lefranc T, Dinelli A, Fernández-Rico C, Dullens RPA, Tailleur J, Bartolo D.
2025. Synthetic quorum sensing and absorbing phase transitions in colloidal active
matter. Physical Review X. 15(3), 031050.
mla: Lefranc, Thibault, et al. “Synthetic Quorum Sensing and Absorbing Phase Transitions
in Colloidal Active Matter.” Physical Review X, vol. 15, no. 3, 031050,
American Physical Society, 2025, doi:10.1103/8csn-71jk.
short: T. Lefranc, A. Dinelli, C. Fernández-Rico, R.P.A. Dullens, J. Tailleur, D.
Bartolo, Physical Review X 15 (2025).
date_created: 2026-06-30T06:32:31Z
date_published: 2025-08-22T00:00:00Z
date_updated: 2026-07-15T07:21:38Z
day: '22'
ddc:
- '530'
doi: 10.1103/8csn-71jk
extern: '1'
external_id:
arxiv:
- '2502.13919'
fulldoi: https://doi.org/10.1103/8csn-71jk
has_accepted_license: '1'
intvolume: ' 15'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1103/8csn-71jk
month: '08'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
issn:
- 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Synthetic quorum sensing and absorbing phase transitions in colloidal active
matter
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2025'
...
---
APC_amount: 4863,6 EUR
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '17493'
abstract:
- lang: eng
text: Estimating global properties of many-body quantum systems such as entropy
or bipartite entanglement is a notoriously difficult task, typically requiring
a number of measurements or classical postprocessing resources growing exponentially
in the system size. In this work, we address the problem of estimating global
entropies and mixed-state entanglement via partial-transposed (PT) moments and
show that efficient estimation strategies exist under the assumption that all
the spatial correlation lengths are finite. Focusing on one-dimensional systems,
we identify a set of approximate factorization conditions (AFCs) on the system
density matrix, which allow us to reconstruct entropies and PT moments from information
on local subsystems. This identification yields a simple and efficient strategy
for entropy and entanglement estimation. Our method could be implemented in different
ways, depending on how information on local subsystems is extracted. Focusing
on randomized measurements providing a practical and common measurement scheme,
we prove that our protocol requires only polynomially many measurements and postprocessing
operations, assuming that the state to be measured satisfies the AFCs. We prove
that the AFCs hold for finite-depth quantum-circuit states and translation-invariant
matrix-product density operators and provide numerical evidence that they are
satisfied in more general, physically interesting cases, including thermal states
of local Hamiltonians. We argue that our method could be practically useful to
detect bipartite mixed-state entanglement for large numbers of qubits available
in today’s quantum platforms.
acknowledgement: B. V. acknowledges funding from the Austrian Science Foundation (Grant
No. FWF, P 32597 N), from the French National Research Agency via the JCJC project
QRand (Grant No. ANR-20-CE47-0005), and via the research programs Plan France 2030
EPIQ (Grant No. ANR-22-PETQ-0007), QUBITAF (Grant No. ANR-22-PETQ-0004), and HQI
(Grant No. ANR-22-PNCQ-0002). M. L. and M. S. acknowledge support by the European
Research Council under the European Union’s Horizon 2020 research and innovation
program (Grant Agreement No. 850899). M. S. acknowledges the hospitality of KITP
supported in part by the National Science Foundation under Grants No. NSF PHY-1748958
and No. NSF PHY-2309135. J. I. C. is supported by the Hightech Agenda Bayern Plus
through the Munich Quantum Valley and the German Federal Ministry of Education and
Research through EQUAHUMO (Grant No. 13N16066). P. Z. acknowledges funding from
the European Union’s Horizon 2020 research and innovation program under Grant Agreement
No. 101113690 (PASQuanS2.1).
article_number: '031035'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Benoît
full_name: Vermersch, Benoît
last_name: Vermersch
- first_name: Marko
full_name: Ljubotina, Marko
id: F75EE9BE-5C90-11EA-905D-16643DDC885E
last_name: Ljubotina
orcid: 0000-0003-0038-7068
- first_name: J. Ignacio
full_name: Cirac, J. Ignacio
last_name: Cirac
- first_name: Peter
full_name: Zoller, Peter
last_name: Zoller
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
- first_name: Lorenzo
full_name: Piroli, Lorenzo
last_name: Piroli
citation:
ama: Vermersch B, Ljubotina M, Cirac JI, Zoller P, Serbyn M, Piroli L. Many-body
entropies and entanglement from polynomially many local measurements. Physical
Review X. 2024;14(3). doi:10.1103/physrevx.14.031035
apa: Vermersch, B., Ljubotina, M., Cirac, J. I., Zoller, P., Serbyn, M., & Piroli,
L. (2024). Many-body entropies and entanglement from polynomially many local measurements.
Physical Review X. American Physical Society. https://doi.org/10.1103/physrevx.14.031035
chicago: Vermersch, Benoît, Marko Ljubotina, J. Ignacio Cirac, Peter Zoller, Maksym
Serbyn, and Lorenzo Piroli. “Many-Body Entropies and Entanglement from Polynomially
Many Local Measurements.” Physical Review X. American Physical Society,
2024. https://doi.org/10.1103/physrevx.14.031035.
ieee: B. Vermersch, M. Ljubotina, J. I. Cirac, P. Zoller, M. Serbyn, and L. Piroli,
“Many-body entropies and entanglement from polynomially many local measurements,”
Physical Review X, vol. 14, no. 3. American Physical Society, 2024.
ista: Vermersch B, Ljubotina M, Cirac JI, Zoller P, Serbyn M, Piroli L. 2024. Many-body
entropies and entanglement from polynomially many local measurements. Physical
Review X. 14(3), 031035.
mla: Vermersch, Benoît, et al. “Many-Body Entropies and Entanglement from Polynomially
Many Local Measurements.” Physical Review X, vol. 14, no. 3, 031035, American
Physical Society, 2024, doi:10.1103/physrevx.14.031035.
short: B. Vermersch, M. Ljubotina, J.I. Cirac, P. Zoller, M. Serbyn, L. Piroli,
Physical Review X 14 (2024).
date_created: 2024-09-04T18:57:11Z
date_published: 2024-08-26T00:00:00Z
date_updated: 2025-09-08T09:04:14Z
day: '26'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/physrevx.14.031035
ec_funded: 1
external_id:
arxiv:
- '2311.08108'
isi:
- '001299667100002'
file:
- access_level: open_access
checksum: 1b114acc89025120727200681e4e9074
content_type: application/pdf
creator: cchlebak
date_created: 2024-09-05T09:39:00Z
date_updated: 2024-09-05T09:39:00Z
file_id: '17532'
file_name: 2024_PhysRevX_Vermersch.pdf
file_size: 1408836
relation: main_file
success: 1
file_date_updated: 2024-09-05T09:39:00Z
fulldoi: https://doi.org/10.1103/physrevx.14.031035
has_accepted_license: '1'
intvolume: ' 14'
isi: 1
issue: '3'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Physical Review X
publication_identifier:
issn:
- 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Many-body entropies and entanglement from polynomially many local measurements
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 14
year: '2024'
...
---
_id: '12277'
abstract:
- lang: eng
text: Cell migration in confining physiological environments relies on the concerted
dynamics of several cellular components, including protrusions, adhesions with
the environment, and the cell nucleus. However, it remains poorly understood how
the dynamic interplay of these components and the cell polarity determine the
emergent migration behavior at the cellular scale. Here, we combine data-driven
inference with a mechanistic bottom-up approach to develop a model for protrusion
and polarity dynamics in confined cell migration, revealing how the cellular dynamics
adapt to confining geometries. Specifically, we use experimental data of joint
protrusion-nucleus migration trajectories of cells on confining micropatterns
to systematically determine a mechanistic model linking the stochastic dynamics
of cell polarity, protrusions, and nucleus. This model indicates that the cellular
dynamics adapt to confining constrictions through a switch in the polarity dynamics
from a negative to a positive self-reinforcing feedback loop. Our model further
reveals how this feedback loop leads to stereotypical cycles of protrusion-nucleus
dynamics that drive the migration of the cell through constrictions. These cycles
are disrupted upon perturbation of cytoskeletal components, indicating that the
positive feedback is controlled by cellular migration mechanisms. Our data-driven
theoretical approach therefore identifies polarity feedback adaptation as a key
mechanism in confined cell migration.
acknowledgement: "We thank Grzegorz Gradziuk, StevenRiedijk, Janni Harju, and M. R.
Schnucki for helpful discussions, and Andriy Goychuk for advice on the image segmentation.
This project\r\nwas funded by the Deutsche Forschungsgemeinschaft (DFG, German Research
Foundation), Project No. 201269156—SFB 1032 (Projects B01 and B12). D. B. B. is
supported by the NOMIS Foundation and in part by a DFG fellowship within the Graduate
School of Quantitative Biosciences Munich (QBM), as well as by the Joachim Herz
Stiftung."
article_number: '031041'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: David
full_name: Brückner, David
id: e1e86031-6537-11eb-953a-f7ab92be508d
last_name: Brückner
orcid: 0000-0001-7205-2975
- first_name: Matthew
full_name: Schmitt, Matthew
last_name: Schmitt
- first_name: Alexandra
full_name: Fink, Alexandra
last_name: Fink
- first_name: Georg
full_name: Ladurner, Georg
last_name: Ladurner
- first_name: Johannes
full_name: Flommersfeld, Johannes
last_name: Flommersfeld
- first_name: Nicolas
full_name: Arlt, Nicolas
last_name: Arlt
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Joachim O.
full_name: Rädler, Joachim O.
last_name: Rädler
- first_name: Chase P.
full_name: Broedersz, Chase P.
last_name: Broedersz
citation:
ama: Brückner D, Schmitt M, Fink A, et al. Geometry adaptation of protrusion and
polarity dynamics in confined cell migration. Physical Review X. 2022;12(3).
doi:10.1103/physrevx.12.031041
apa: Brückner, D., Schmitt, M., Fink, A., Ladurner, G., Flommersfeld, J., Arlt,
N., … Broedersz, C. P. (2022). Geometry adaptation of protrusion and polarity
dynamics in confined cell migration. Physical Review X. American Physical
Society. https://doi.org/10.1103/physrevx.12.031041
chicago: Brückner, David, Matthew Schmitt, Alexandra Fink, Georg Ladurner, Johannes
Flommersfeld, Nicolas Arlt, Edouard B Hannezo, Joachim O. Rädler, and Chase P.
Broedersz. “Geometry Adaptation of Protrusion and Polarity Dynamics in Confined
Cell Migration.” Physical Review X. American Physical Society, 2022. https://doi.org/10.1103/physrevx.12.031041.
ieee: D. Brückner et al., “Geometry adaptation of protrusion and polarity
dynamics in confined cell migration,” Physical Review X, vol. 12, no. 3.
American Physical Society, 2022.
ista: Brückner D, Schmitt M, Fink A, Ladurner G, Flommersfeld J, Arlt N, Hannezo
EB, Rädler JO, Broedersz CP. 2022. Geometry adaptation of protrusion and polarity
dynamics in confined cell migration. Physical Review X. 12(3), 031041.
mla: Brückner, David, et al. “Geometry Adaptation of Protrusion and Polarity Dynamics
in Confined Cell Migration.” Physical Review X, vol. 12, no. 3, 031041,
American Physical Society, 2022, doi:10.1103/physrevx.12.031041.
short: D. Brückner, M. Schmitt, A. Fink, G. Ladurner, J. Flommersfeld, N. Arlt,
E.B. Hannezo, J.O. Rädler, C.P. Broedersz, Physical Review X 12 (2022).
date_created: 2023-01-16T10:02:06Z
date_published: 2022-09-20T00:00:00Z
date_updated: 2023-08-04T10:25:49Z
day: '20'
ddc:
- '530'
- '570'
department:
- _id: EdHa
doi: 10.1103/physrevx.12.031041
external_id:
arxiv:
- '2106.01014'
isi:
- '000861534700001'
file:
- access_level: open_access
checksum: 40a8fbc3663bf07b37cb80020974d40d
content_type: application/pdf
creator: dernst
date_created: 2023-01-30T11:07:27Z
date_updated: 2023-01-30T11:07:27Z
file_id: '12458'
file_name: 2022_PhysicalReviewX_Brueckner.pdf
file_size: 4686804
relation: main_file
success: 1
file_date_updated: 2023-01-30T11:07:27Z
fulldoi: https://doi.org/10.1103/physrevx.12.031041
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
issue: '3'
keyword:
- General Physics and Astronomy
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
issn:
- 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Geometry adaptation of protrusion and polarity dynamics in confined cell migration
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2022'
...
---
_id: '7570'
abstract:
- lang: eng
text: The relaxation of few-body quantum systems can strongly depend on the initial
state when the system’s semiclassical phase space is mixed; i.e., regions of chaotic
motion coexist with regular islands. In recent years, there has been much effort
to understand the process of thermalization in strongly interacting quantum systems
that often lack an obvious semiclassical limit. The time-dependent variational
principle (TDVP) allows one to systematically derive an effective classical (nonlinear)
dynamical system by projecting unitary many-body dynamics onto a manifold of weakly
entangled variational states. We demonstrate that such dynamical systems generally
possess mixed phase space. When TDVP errors are small, the mixed phase space leaves
a footprint on the exact dynamics of the quantum model. For example, when the
system is initialized in a state belonging to a stable periodic orbit or the surrounding
regular region, it exhibits persistent many-body quantum revivals. As a proof
of principle, we identify new types of “quantum many-body scars,” i.e., initial
states that lead to long-time oscillations in a model of interacting Rydberg atoms
in one and two dimensions. Intriguingly, the initial states that give rise to
most robust revivals are typically entangled states. On the other hand, even when
TDVP errors are large, as in the thermalizing tilted-field Ising model, initializing
the system in a regular region of phase space leads to a surprising slowdown of
thermalization. Our work establishes TDVP as a method for identifying interacting
quantum systems with anomalous dynamics in arbitrary dimensions. Moreover, the
mixed phase space classical variational equations allow one to find slowly thermalizing
initial conditions in interacting models. Our results shed light on a link between
classical and quantum chaos, pointing toward possible extensions of the classical
Kolmogorov-Arnold-Moser theorem to quantum systems.
article_number: '011055'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Alexios
full_name: Michailidis, Alexios
id: 36EBAD38-F248-11E8-B48F-1D18A9856A87
last_name: Michailidis
orcid: 0000-0002-8443-1064
- first_name: C. J.
full_name: Turner, C. J.
last_name: Turner
- first_name: Z.
full_name: Papić, Z.
last_name: Papić
- first_name: D. A.
full_name: Abanin, D. A.
last_name: Abanin
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Michailidis A, Turner CJ, Papić Z, Abanin DA, Serbyn M. Slow quantum thermalization
and many-body revivals from mixed phase space. Physical Review X. 2020;10(1).
doi:10.1103/physrevx.10.011055
apa: Michailidis, A., Turner, C. J., Papić, Z., Abanin, D. A., & Serbyn, M.
(2020). Slow quantum thermalization and many-body revivals from mixed phase space.
Physical Review X. American Physical Society. https://doi.org/10.1103/physrevx.10.011055
chicago: Michailidis, Alexios, C. J. Turner, Z. Papić, D. A. Abanin, and Maksym
Serbyn. “Slow Quantum Thermalization and Many-Body Revivals from Mixed Phase Space.”
Physical Review X. American Physical Society, 2020. https://doi.org/10.1103/physrevx.10.011055.
ieee: A. Michailidis, C. J. Turner, Z. Papić, D. A. Abanin, and M. Serbyn, “Slow
quantum thermalization and many-body revivals from mixed phase space,” Physical
Review X, vol. 10, no. 1. American Physical Society, 2020.
ista: Michailidis A, Turner CJ, Papić Z, Abanin DA, Serbyn M. 2020. Slow quantum
thermalization and many-body revivals from mixed phase space. Physical Review
X. 10(1), 011055.
mla: Michailidis, Alexios, et al. “Slow Quantum Thermalization and Many-Body Revivals
from Mixed Phase Space.” Physical Review X, vol. 10, no. 1, 011055, American
Physical Society, 2020, doi:10.1103/physrevx.10.011055.
short: A. Michailidis, C.J. Turner, Z. Papić, D.A. Abanin, M. Serbyn, Physical Review
X 10 (2020).
date_created: 2020-03-08T18:02:01Z
date_published: 2020-03-04T00:00:00Z
date_updated: 2023-08-18T07:01:07Z
day: '04'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/physrevx.10.011055
external_id:
arxiv:
- '1905.08564'
isi:
- '000517969300001'
file:
- access_level: open_access
checksum: 4b3f2c13873d35230173c73d0e11c408
content_type: application/pdf
creator: dernst
date_created: 2020-03-12T12:13:07Z
date_updated: 2020-07-14T12:48:00Z
file_id: '7581'
file_name: 2020_PhysicalReviewX_Michailidis.pdf
file_size: 17828638
relation: main_file
file_date_updated: 2020-07-14T12:48:00Z
fulldoi: https://doi.org/10.1103/physrevx.10.011055
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
issn:
- 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/classical-physics-helps-predict-fate-of-interacting-quantum-systems/
scopus_import: '1'
status: public
title: Slow quantum thermalization and many-body revivals from mixed phase space
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2020'
...
---
_id: '1114'
abstract:
- lang: eng
text: Nonequilibrium phase transitions exist in damped-driven open quantum systems
when the continuous tuning of an external parameter leads to a transition between
two robust steady states. In second-order transitions this change is abrupt at
a critical point, whereas in first-order transitions the two phases can coexist
in a critical hysteresis domain. Here, we report the observation of a first-order
dissipative quantum phase transition in a driven circuit quantum electrodynamics
system. It takes place when the photon blockade of the driven cavity-atom system
is broken by increasing the drive power. The observed experimental signature is
a bimodal phase space distribution with varying weights controlled by the drive
strength. Our measurements show an improved stabilization of the classical attractors
up to the millisecond range when the size of the quantum system is increased from
one to three artificial atoms. The formation of such robust pointer states could
be used for new quantum measurement schemes or to investigate multiphoton phases
of finite-size, nonlinear, open quantum systems.
article_number: '011012'
article_processing_charge: Yes
author:
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: András
full_name: Dombi, András
last_name: Dombi
- first_name: András
full_name: Vukics, András
last_name: Vukics
- first_name: Andreas
full_name: Wallraff, Andreas
last_name: Wallraff
- first_name: Peter
full_name: Domokos, Peter
last_name: Domokos
citation:
ama: Fink JM, Dombi A, Vukics A, Wallraff A, Domokos P. Observation of the photon
blockade breakdown phase transition. Physical Review X. 2017;7(1). doi:10.1103/PhysRevX.7.011012
apa: Fink, J. M., Dombi, A., Vukics, A., Wallraff, A., & Domokos, P. (2017).
Observation of the photon blockade breakdown phase transition. Physical Review
X. American Physical Society. https://doi.org/10.1103/PhysRevX.7.011012
chicago: Fink, Johannes M, András Dombi, András Vukics, Andreas Wallraff, and Peter
Domokos. “Observation of the Photon Blockade Breakdown Phase Transition.” Physical
Review X. American Physical Society, 2017. https://doi.org/10.1103/PhysRevX.7.011012.
ieee: J. M. Fink, A. Dombi, A. Vukics, A. Wallraff, and P. Domokos, “Observation
of the photon blockade breakdown phase transition,” Physical Review X,
vol. 7, no. 1. American Physical Society, 2017.
ista: Fink JM, Dombi A, Vukics A, Wallraff A, Domokos P. 2017. Observation of the
photon blockade breakdown phase transition. Physical Review X. 7(1), 011012.
mla: Fink, Johannes M., et al. “Observation of the Photon Blockade Breakdown Phase
Transition.” Physical Review X, vol. 7, no. 1, 011012, American Physical
Society, 2017, doi:10.1103/PhysRevX.7.011012.
short: J.M. Fink, A. Dombi, A. Vukics, A. Wallraff, P. Domokos, Physical Review
X 7 (2017).
date_created: 2018-12-11T11:50:13Z
date_published: 2017-01-31T00:00:00Z
date_updated: 2025-07-10T11:50:07Z
day: '31'
ddc:
- '539'
department:
- _id: JoFi
doi: 10.1103/PhysRevX.7.011012
external_id:
isi:
- '000397450500001'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:12:52Z
date_updated: 2018-12-12T10:12:52Z
file_id: '4972'
file_name: IST-2017-753-v1+1_PhysRevX.7.011012.pdf
file_size: 1172926
relation: main_file
file_date_updated: 2018-12-12T10:12:52Z
fulldoi: https://doi.org/10.1103/PhysRevX.7.011012
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
issn:
- 2160-3308
publication_status: published
publisher: American Physical Society
publist_id: '6252'
pubrep_id: '753'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Observation of the photon blockade breakdown phase transition
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2017'
...