---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18253'
abstract:
- lang: eng
  text: PCNA, the ring that encircles DNA maintaining the processivity of DNA polymerases,
    is modified by ubiquitin and SUMO. Whereas ubiquitin is required for bypassing
    lesions through the DNA damage tolerance (DDT) pathways, we show here that SUMOylation
    represses another pathway, salvage recombination. The Srs2 helicase is recruited
    to SUMOylated PCNA and prevents the salvage pathway from acting. The pathway can
    be induced by overexpressing the PCNA unloader Elg1, or the homologous recombination
    protein Rad52. Our results underscore the role of PCNA modifications in controlling
    the various bypass and DNA repair mechanisms.
article_number: 00705-20
article_processing_charge: Yes
article_type: original
author:
- first_name: Matan
  full_name: Arbel, Matan
  last_name: Arbel
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Soumitra
  full_name: Sau, Soumitra
  last_name: Sau
- first_name: Batia
  full_name: Liefshitz, Batia
  last_name: Liefshitz
- first_name: Martin
  full_name: Kupiec, Martin
  last_name: Kupiec
citation:
  ama: Arbel M, Bronstein AM, Sau S, Liefshitz B, Kupiec M. Access to PCNA by Srs2
    and Elg1 controls the choice between alternative repair pathways in Saccharomyces
    cerevisiae. <i>mBio</i>. 2020;11(3). doi:<a href="https://doi.org/10.1128/mbio.00705-20">10.1128/mbio.00705-20</a>
  apa: Arbel, M., Bronstein, A. M., Sau, S., Liefshitz, B., &#38; Kupiec, M. (2020).
    Access to PCNA by Srs2 and Elg1 controls the choice between alternative repair
    pathways in Saccharomyces cerevisiae. <i>MBio</i>. American Society for Microbiology.
    <a href="https://doi.org/10.1128/mbio.00705-20">https://doi.org/10.1128/mbio.00705-20</a>
  chicago: Arbel, Matan, Alex M. Bronstein, Soumitra Sau, Batia Liefshitz, and Martin
    Kupiec. “Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative
    Repair Pathways in Saccharomyces Cerevisiae.” <i>MBio</i>. American Society for
    Microbiology, 2020. <a href="https://doi.org/10.1128/mbio.00705-20">https://doi.org/10.1128/mbio.00705-20</a>.
  ieee: M. Arbel, A. M. Bronstein, S. Sau, B. Liefshitz, and M. Kupiec, “Access to
    PCNA by Srs2 and Elg1 controls the choice between alternative repair pathways
    in Saccharomyces cerevisiae,” <i>mBio</i>, vol. 11, no. 3. American Society for
    Microbiology, 2020.
  ista: Arbel M, Bronstein AM, Sau S, Liefshitz B, Kupiec M. 2020. Access to PCNA
    by Srs2 and Elg1 controls the choice between alternative repair pathways in Saccharomyces
    cerevisiae. mBio. 11(3), 00705-20.
  mla: Arbel, Matan, et al. “Access to PCNA by Srs2 and Elg1 Controls the Choice between
    Alternative Repair Pathways in Saccharomyces Cerevisiae.” <i>MBio</i>, vol. 11,
    no. 3, 00705-20, American Society for Microbiology, 2020, doi:<a href="https://doi.org/10.1128/mbio.00705-20">10.1128/mbio.00705-20</a>.
  short: M. Arbel, A.M. Bronstein, S. Sau, B. Liefshitz, M. Kupiec, MBio 11 (2020).
date_created: 2024-10-08T13:06:43Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2024-10-15T10:50:42Z
day: '01'
doi: 10.1128/mbio.00705-20
extern: '1'
external_id:
  pmid:
  - '32371600'
intvolume: '        11'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1128/mbio.00705-20
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: mBio
publication_identifier:
  eissn:
  - 2150-7511
  issn:
  - 2161-2129
publication_status: published
publisher: American Society for Microbiology
quality_controlled: '1'
scopus_import: '1'
status: public
title: Access to PCNA by Srs2 and Elg1 controls the choice between alternative repair
  pathways in Saccharomyces cerevisiae
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2020'
...