---
OA_type: closed access
_id: '17877'
abstract:
- lang: eng
  text: Chemical reactions that occur at nanostructured electrodes have garnered widespread
    interest because of their potential applications in fields including nanotechnology,
    green chemistry and fundamental physical organic chemistry. Much of our present
    understanding of these reactions comes from probes that interrogate ensembles
    of molecules undergoing various stages of the transformation concurrently. Exquisite
    control over single-molecule reactivity lets us construct new molecules and further
    our understanding of nanoscale chemical phenomena. We can study single molecules
    using instruments such as the scanning tunnelling microscope, which can additionally
    be part of a mechanically controlled break junction. These are unique tools that
    can offer a high level of detail. They probe the electronic conductance of individual
    molecules and catalyse chemical reactions by establishing environments with reactive
    metal sites on nanoscale electrodes. This Review describes how chemical reactions
    involving bond cleavage and formation can be triggered at nanoscale electrodes
    and studied one molecule at a time.
article_processing_charge: No
article_type: review
author:
- first_name: Ilana
  full_name: Stone, Ilana
  last_name: Stone
- first_name: Rachel L.
  full_name: Starr, Rachel L.
  last_name: Starr
- first_name: Yaping
  full_name: Zang, Yaping
  last_name: Zang
- first_name: Colin
  full_name: Nuckolls, Colin
  last_name: Nuckolls
- first_name: Michael L.
  full_name: Steigerwald, Michael L.
  last_name: Steigerwald
- first_name: Tristan H.
  full_name: Lambert, Tristan H.
  last_name: Lambert
- first_name: Xavier
  full_name: Roy, Xavier
  last_name: Roy
- first_name: Latha
  full_name: Venkataraman, Latha
  id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
  last_name: Venkataraman
  orcid: 0000-0002-6957-6089
citation:
  ama: Stone I, Starr RL, Zang Y, et al. A single-molecule blueprint for synthesis.
    <i>Nature Reviews Chemistry</i>. 2021;5(10):695-710. doi:<a href="https://doi.org/10.1038/s41570-021-00316-y">10.1038/s41570-021-00316-y</a>
  apa: Stone, I., Starr, R. L., Zang, Y., Nuckolls, C., Steigerwald, M. L., Lambert,
    T. H., … Venkataraman, L. (2021). A single-molecule blueprint for synthesis. <i>Nature
    Reviews Chemistry</i>. Springer Nature. <a href="https://doi.org/10.1038/s41570-021-00316-y">https://doi.org/10.1038/s41570-021-00316-y</a>
  chicago: Stone, Ilana, Rachel L. Starr, Yaping Zang, Colin Nuckolls, Michael L.
    Steigerwald, Tristan H. Lambert, Xavier Roy, and Latha Venkataraman. “A Single-Molecule
    Blueprint for Synthesis.” <i>Nature Reviews Chemistry</i>. Springer Nature, 2021.
    <a href="https://doi.org/10.1038/s41570-021-00316-y">https://doi.org/10.1038/s41570-021-00316-y</a>.
  ieee: I. Stone <i>et al.</i>, “A single-molecule blueprint for synthesis,” <i>Nature
    Reviews Chemistry</i>, vol. 5, no. 10. Springer Nature, pp. 695–710, 2021.
  ista: Stone I, Starr RL, Zang Y, Nuckolls C, Steigerwald ML, Lambert TH, Roy X,
    Venkataraman L. 2021. A single-molecule blueprint for synthesis. Nature Reviews
    Chemistry. 5(10), 695–710.
  mla: Stone, Ilana, et al. “A Single-Molecule Blueprint for Synthesis.” <i>Nature
    Reviews Chemistry</i>, vol. 5, no. 10, Springer Nature, 2021, pp. 695–710, doi:<a
    href="https://doi.org/10.1038/s41570-021-00316-y">10.1038/s41570-021-00316-y</a>.
  short: I. Stone, R.L. Starr, Y. Zang, C. Nuckolls, M.L. Steigerwald, T.H. Lambert,
    X. Roy, L. Venkataraman, Nature Reviews Chemistry 5 (2021) 695–710.
date_created: 2024-09-06T13:11:31Z
date_published: 2021-08-25T00:00:00Z
date_updated: 2024-12-10T10:05:51Z
day: '25'
doi: 10.1038/s41570-021-00316-y
extern: '1'
external_id:
  pmid:
  - '37118183'
intvolume: '         5'
issue: '10'
language:
- iso: eng
month: '08'
oa_version: None
page: 695-710
pmid: 1
publication: Nature Reviews Chemistry
publication_identifier:
  issn:
  - 2397-3358
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: A single-molecule blueprint for synthesis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2021'
...