---
_id: '700'
abstract:
- lang: eng
  text: Microtubules provide the mechanical force required for chromosome separation
    during mitosis. However, little is known about the dynamic (high-frequency) mechanical
    properties of microtubules. Here, we theoretically propose to control the vibrations
    of a doubly clamped microtubule by tip electrodes and to detect its motion via
    the optomechanical coupling between the vibrational modes of the microtubule and
    an optical cavity. In the presence of a red-detuned strong pump laser, this coupling
    leads to optomechanical-induced transparency of an optical probe field, which
    can be detected with state-of-the art technology. The center frequency and line
    width of the transparency peak give the resonance frequency and damping rate of
    the microtubule, respectively, while the height of the peak reveals information
    about the microtubule-cavity field coupling. Our method opens the new possibilities
    to gain information about the physical properties of microtubules, which will
    enhance our capability to design physical cancer treatment protocols as alternatives
    to chemotherapeutic drugs.
article_number: '012404'
article_processing_charge: No
arxiv: 1
author:
- first_name: Shabir
  full_name: Barzanjeh, Shabir
  id: 2D25E1F6-F248-11E8-B48F-1D18A9856A87
  last_name: Barzanjeh
  orcid: 0000-0003-0415-1423
- first_name: Vahid
  full_name: Salari, Vahid
  last_name: Salari
- first_name: Jack
  full_name: Tuszynski, Jack
  last_name: Tuszynski
- first_name: Michal
  full_name: Cifra, Michal
  last_name: Cifra
- first_name: Christoph
  full_name: Simon, Christoph
  last_name: Simon
citation:
  ama: Barzanjeh S, Salari V, Tuszynski J, Cifra M, Simon C. Optomechanical proposal
    for monitoring microtubule mechanical vibrations. <i>Physical Review E</i>. 2017;96(1).
    doi:<a href="https://doi.org/10.1103/PhysRevE.96.012404">10.1103/PhysRevE.96.012404</a>
  apa: Barzanjeh, S., Salari, V., Tuszynski, J., Cifra, M., &#38; Simon, C. (2017).
    Optomechanical proposal for monitoring microtubule mechanical vibrations. <i>Physical
    Review E</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevE.96.012404">https://doi.org/10.1103/PhysRevE.96.012404</a>
  chicago: Barzanjeh, Shabir, Vahid Salari, Jack Tuszynski, Michal Cifra, and Christoph
    Simon. “Optomechanical Proposal for Monitoring Microtubule Mechanical Vibrations.”
    <i>Physical Review E</i>. American Physical Society, 2017. <a href="https://doi.org/10.1103/PhysRevE.96.012404">https://doi.org/10.1103/PhysRevE.96.012404</a>.
  ieee: S. Barzanjeh, V. Salari, J. Tuszynski, M. Cifra, and C. Simon, “Optomechanical
    proposal for monitoring microtubule mechanical vibrations,” <i>Physical Review
    E</i>, vol. 96, no. 1. American Physical Society, 2017.
  ista: Barzanjeh S, Salari V, Tuszynski J, Cifra M, Simon C. 2017. Optomechanical
    proposal for monitoring microtubule mechanical vibrations. Physical Review E.
    96(1), 012404.
  mla: Barzanjeh, Shabir, et al. “Optomechanical Proposal for Monitoring Microtubule
    Mechanical Vibrations.” <i>Physical Review E</i>, vol. 96, no. 1, 012404, American
    Physical Society, 2017, doi:<a href="https://doi.org/10.1103/PhysRevE.96.012404">10.1103/PhysRevE.96.012404</a>.
  short: S. Barzanjeh, V. Salari, J. Tuszynski, M. Cifra, C. Simon, Physical Review
    E 96 (2017).
das_tickbox: '1'
date_created: 2018-12-11T11:48:00Z
date_published: 2017-07-12T00:00:00Z
date_updated: 2026-08-12T14:29:59Z
day: '12'
department:
- _id: JoFi
doi: 10.1103/PhysRevE.96.012404
ec_funded: 1
external_id:
  arxiv:
  - '1612.07061'
  isi:
  - '000405367200012'
fulldoi: https://doi.org/10.1103/PhysRevE.96.012404
intvolume: '        96'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1612.07061
month: '07'
oa: 1
oa_version: Submitted Version
project:
- _id: 258047B6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '707438'
  name: 'Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination
    with cavity Optomechanics'
publication: Physical Review E
publication_identifier:
  issn:
  - 2470-0045
publication_status: published
publisher: American Physical Society
publist_id: '6997'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Optomechanical proposal for monitoring microtubule mechanical vibrations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 96
year: '2017'
...
---
_id: '959'
abstract:
- lang: eng
  text: In this work it is shown that scale-free tails in metabolic flux distributions
    inferred in stationary models are an artifact due to reactions involved in thermodynamically
    unfeasible cycles, unbounded by physical constraints and in principle able to
    perform work without expenditure of free energy. After implementing thermodynamic
    constraints by removing such loops, metabolic flux distributions scale meaningfully
    with the physical limiting factors, acquiring in turn a richer multimodal structure
    potentially leading to symmetry breaking while optimizing for objective functions.
article_processing_charge: No
arxiv: 1
author:
- first_name: Daniele
  full_name: De Martino, Daniele
  id: 3FF5848A-F248-11E8-B48F-1D18A9856A87
  last_name: De Martino
  orcid: 0000-0002-5214-4706
citation:
  ama: De Martino D. Scales and multimodal flux distributions in stationary metabolic
    network models via thermodynamics. <i>Physical Review E</i>. 2017;95(6):062419.
    doi:<a href="https://doi.org/10.1103/PhysRevE.95.062419">10.1103/PhysRevE.95.062419</a>
  apa: De Martino, D. (2017). Scales and multimodal flux distributions in stationary
    metabolic network models via thermodynamics. <i>Physical Review E</i>. American
    Physical Society. <a href="https://doi.org/10.1103/PhysRevE.95.062419">https://doi.org/10.1103/PhysRevE.95.062419</a>
  chicago: De Martino, Daniele. “Scales and Multimodal Flux Distributions in Stationary
    Metabolic Network Models via Thermodynamics.” <i>Physical Review E</i>. American
    Physical Society, 2017. <a href="https://doi.org/10.1103/PhysRevE.95.062419">https://doi.org/10.1103/PhysRevE.95.062419</a>.
  ieee: D. De Martino, “Scales and multimodal flux distributions in stationary metabolic
    network models via thermodynamics,” <i>Physical Review E</i>, vol. 95, no. 6.
    American Physical Society, p. 062419, 2017.
  ista: De Martino D. 2017. Scales and multimodal flux distributions in stationary
    metabolic network models via thermodynamics. Physical Review E. 95(6), 062419.
  mla: De Martino, Daniele. “Scales and Multimodal Flux Distributions in Stationary
    Metabolic Network Models via Thermodynamics.” <i>Physical Review E</i>, vol. 95,
    no. 6, American Physical Society, 2017, p. 062419, doi:<a href="https://doi.org/10.1103/PhysRevE.95.062419">10.1103/PhysRevE.95.062419</a>.
  short: D. De Martino, Physical Review E 95 (2017) 062419.
das_tickbox: '1'
date_created: 2018-12-11T11:49:25Z
date_published: 2017-06-28T00:00:00Z
date_updated: 2026-08-12T14:29:35Z
day: '28'
department:
- _id: GaTk
doi: 10.1103/PhysRevE.95.062419
ec_funded: 1
external_id:
  arxiv:
  - '1703.00853'
  isi:
  - '000404546400004'
fulldoi: https://doi.org/10.1103/PhysRevE.95.062419
intvolume: '        95'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1703.00853
month: '06'
oa: 1
oa_version: Submitted Version
page: '062419'
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Physical Review E
publication_identifier:
  issn:
  - 2470-0045
publication_status: published
publisher: American Physical Society
publist_id: '6446'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scales and multimodal flux distributions in stationary metabolic network models
  via thermodynamics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 95
year: '2017'
...
---
OA_place: repository
OA_type: green
_id: '931'
abstract:
- lang: eng
  text: 'In many adult tissues, stem cells and differentiated cells are not homogeneously
    distributed: stem cells are arranged in periodic &quot;niches,&quot; and differentiated
    cells are constantly produced and migrate out of these niches. In this article,
    we provide a general theoretical framework to study mixtures of dividing and actively
    migrating particles, which we apply to biological tissues. We show in particular
    that the interplay between the stresses arising from active cell migration and
    stem cell division give rise to robust stem cell patterns. The instability of
    the tissue leads to spatial patterns which are either steady or oscillating in
    time. The wavelength of the instability has an order of magnitude consistent with
    the biological observations. We also discuss the implications of these results
    for future in vitro and in vivo experiments.'
acknowledgement: The authors thank Jacques Prost and Pierre Recho for helpful discussions,
  as well as the Labex CelTisPhyBio and all its members. E.H. acknowledges for funding
  a Young Researcher Prize from the Bettencourt-Schueller Fondation, and a Junior
  Research Fellowship from Trinity College, Cambridge.
article_number: '022405'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Alice
  full_name: Coucke, Alice
  last_name: Coucke
- first_name: Jean
  full_name: Joanny, Jean
  last_name: Joanny
citation:
  ama: Hannezo EB, Coucke A, Joanny J. Interplay of migratory and division forces
    as a generic mechanism for stem cell patterns. <i>Physical Review E </i>. 2016;93(2).
    doi:<a href="https://doi.org/10.1103/PhysRevE.93.022405">10.1103/PhysRevE.93.022405</a>
  apa: Hannezo, E. B., Coucke, A., &#38; Joanny, J. (2016). Interplay of migratory
    and division forces as a generic mechanism for stem cell patterns. <i>Physical
    Review E </i>. American Institute of Physics. <a href="https://doi.org/10.1103/PhysRevE.93.022405">https://doi.org/10.1103/PhysRevE.93.022405</a>
  chicago: Hannezo, Edouard B, Alice Coucke, and Jean Joanny. “Interplay of Migratory
    and Division Forces as a Generic Mechanism for Stem Cell Patterns.” <i>Physical
    Review E </i>. American Institute of Physics, 2016. <a href="https://doi.org/10.1103/PhysRevE.93.022405">https://doi.org/10.1103/PhysRevE.93.022405</a>.
  ieee: E. B. Hannezo, A. Coucke, and J. Joanny, “Interplay of migratory and division
    forces as a generic mechanism for stem cell patterns,” <i>Physical Review E </i>,
    vol. 93, no. 2. American Institute of Physics, 2016.
  ista: Hannezo EB, Coucke A, Joanny J. 2016. Interplay of migratory and division
    forces as a generic mechanism for stem cell patterns. Physical Review E . 93(2),
    022405.
  mla: Hannezo, Edouard B., et al. “Interplay of Migratory and Division Forces as
    a Generic Mechanism for Stem Cell Patterns.” <i>Physical Review E </i>, vol. 93,
    no. 2, 022405, American Institute of Physics, 2016, doi:<a href="https://doi.org/10.1103/PhysRevE.93.022405">10.1103/PhysRevE.93.022405</a>.
  short: E.B. Hannezo, A. Coucke, J. Joanny, Physical Review E  93 (2016).
date_created: 2018-12-11T11:49:16Z
date_published: 2016-02-08T00:00:00Z
date_updated: 2026-05-20T09:18:55Z
day: '08'
doi: 10.1103/PhysRevE.93.022405
extern: '1'
external_id:
  arxiv:
  - '1512.05896'
  pmid:
  - '26986360'
fulldoi: https://doi.org/10.1103/PhysRevE.93.022405
intvolume: '        93'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.1512.05896'
month: '02'
oa: 1
oa_version: Preprint
pmid: 1
publication: 'Physical Review E '
publication_identifier:
  eissn:
  - 2470-0053
  issn:
  - 2470-0045
publication_status: published
publisher: American Institute of Physics
publist_id: '6509'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interplay of migratory and division forces as a generic mechanism for stem
  cell patterns
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 93
year: '2016'
...