[{"date_published":"2025-02-18T00:00:00Z","month":"02","language":[{"iso":"eng"}],"date_updated":"2026-04-16T12:20:38Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"MiLe"}],"file_date_updated":"2025-02-18T14:25:59Z","oa":1,"_id":"19048","oa_version":"Published Version","acknowledgement":"I am grateful to the European Research Council (ERC) [10.3030/801770] and Austrian\r\nScience Fund (FWF) [10.55776/F1004] for funding my research and to the Physical\r\nReview journals for publishing it. I also want to thank the VCQ (previously CoQuS) and\r\nIQOQI for organizing wonderful networking events for the physics community in Vienna\r\nand Innsbruck, respectively. Moreover, I thank Austrian Science Fund (FWF) for the\r\ncontinuous support for quantum research.","type":"dissertation","citation":{"apa":"Maslov, M. (2025). <i>Emergent physics of rotating quantum impurities in many-body environments</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:19048\">https://doi.org/10.15479/at:ista:19048</a>","chicago":"Maslov, Mikhail. “Emergent Physics of Rotating Quantum Impurities in Many-Body Environments.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/at:ista:19048\">https://doi.org/10.15479/at:ista:19048</a>.","mla":"Maslov, Mikhail. <i>Emergent Physics of Rotating Quantum Impurities in Many-Body Environments</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/at:ista:19048\">10.15479/at:ista:19048</a>.","short":"M. Maslov, Emergent Physics of Rotating Quantum Impurities in Many-Body Environments, Institute of Science and Technology Austria, 2025.","ieee":"M. Maslov, “Emergent physics of rotating quantum impurities in many-body environments,” Institute of Science and Technology Austria, 2025.","ama":"Maslov M. Emergent physics of rotating quantum impurities in many-body environments. 2025. doi:<a href=\"https://doi.org/10.15479/at:ista:19048\">10.15479/at:ista:19048</a>","ista":"Maslov M. 2025. Emergent physics of rotating quantum impurities in many-body environments. Institute of Science and Technology Austria."},"project":[{"call_identifier":"H2020","name":"Angulon: physics and applications of a new quasiparticle","_id":"2688CF98-B435-11E9-9278-68D0E5697425","grant_number":"801770"},{"_id":"7c040762-9f16-11ee-852c-dd79eeee4ab3","grant_number":"F100403","name":"Coherent Optical Metrology Beyond Electric-Dipole-Allowed Transitions"}],"alternative_title":["ISTA Thesis"],"day":"18","status":"public","tmp":{"short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"ec_funded":1,"supervisor":[{"first_name":"Mikhail","last_name":"Lemeshko","orcid":"0000-0002-6990-7802","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","full_name":"Lemeshko, Mikhail"}],"degree_awarded":"PhD","title":"Emergent physics of rotating quantum impurities in many-body environments","article_processing_charge":"No","page":"86","publication_status":"published","abstract":[{"lang":"eng","text":"Rotations are found in physics problems at all scales: from spatial motion of celestial bodies, to transitions between quantum states of atoms and molecules. Mathematically, they represent a fundamental class of transformations and symmetries. Unlike spatial displacements, rotational transformations in three-dimensional space  are non-commutative: the result of applying a sequence of rotations depends on the order of these operations. This feature makes the emergent physics that involves rotations rather intricate, but instrumental for studies of highly-interconnected many-body systems. In the presence of an environment, rotational properties of an object change, due to the interaction with particles of the environment. Owing to the complexity of this interaction, it can be engineered to exhibit certain properties of interest. In this Thesis, we examine several scenarios of how the rotational behavior of an impurity can be modified by interactions with its environment."}],"acknowledged_ssus":[{"_id":"CampIT"},{"_id":"E-Lib"},{"_id":"SSU"}],"related_material":{"record":[{"relation":"part_of_dissertation","id":"10845","status":"public"},{"status":"public","id":"7933","relation":"part_of_dissertation"},{"status":"public","id":"18087","relation":"part_of_dissertation"}]},"author":[{"first_name":"Mikhail","last_name":"Maslov","full_name":"Maslov, Mikhail","id":"2E65BB0E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4074-2570"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","has_accepted_license":"1","ddc":["539","535","541"],"corr_author":"1","file":[{"file_id":"19061","date_updated":"2025-02-18T14:25:59Z","file_size":7779825,"access_level":"open_access","relation":"main_file","checksum":"5822a4dd31724c512b37c658af1787ab","file_name":"thesis_Maslov.pdf","content_type":"application/pdf","date_created":"2025-02-18T14:25:59Z","creator":"mmaslov"},{"creator":"mmaslov","file_name":"thesis_Maslov_source.zip","content_type":"application/zip","date_created":"2025-02-18T14:25:59Z","file_size":14453726,"date_updated":"2025-02-18T14:25:59Z","access_level":"open_access","relation":"source_file","checksum":"89bdce4774406d26ceca88a8bbcd6a9a","file_id":"19062"}],"doi":"10.15479/at:ista:19048","publication_identifier":{"issn":["2663-337X"]},"date_created":"2025-02-18T01:41:27Z","year":"2025"},{"date_created":"2025-04-14T06:59:06Z","year":"2025","doi":"10.15479/AT-ISTA-19557","publication_identifier":{"issn":["2663-337X"]},"corr_author":"1","file":[{"file_id":"19561","checksum":"50290a8604edb0a720387f01e9d59fe4","relation":"source_file","access_level":"closed","date_updated":"2025-04-15T08:43:36Z","file_size":21783427,"date_created":"2025-04-15T08:43:36Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"Schwarz_Thesis_2025_FINAL.docx","creator":"lschwarz"},{"content_type":"application/pdf","file_name":"Schwarz_Thesis_2025_FINALpdfa.pdf","date_created":"2025-04-15T08:43:42Z","creator":"lschwarz","file_id":"19562","embargo":"2026-10-15","file_size":11432175,"date_updated":"2026-03-27T13:15:08Z","embargo_to":"open_access","access_level":"closed","checksum":"ed028488180ac4901e018ef1c330cf01","relation":"main_file"}],"has_accepted_license":"1","ddc":["570"],"author":[{"id":"29A8453C-F248-11E8-B48F-1D18A9856A87","full_name":"Schwarz, Lena A","last_name":"Schwarz","first_name":"Lena A"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"},{"_id":"ScienComp"}],"related_material":{"record":[{"status":"public","id":"12802","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"9429"}]},"article_processing_charge":"No","page":"124","publication_status":"published","supervisor":[{"first_name":"Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia"}],"degree_awarded":"PhD","title":"Mapping developmental dynamics of autism spectrum disorder mouse models at single-cell resolution","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"alternative_title":["ISTA Thesis"],"status":"public","day":"14","citation":{"short":"L.A. Schwarz, Mapping Developmental Dynamics of Autism Spectrum Disorder Mouse Models at Single-Cell Resolution, Institute of Science and Technology Austria, 2025.","ieee":"L. A. Schwarz, “Mapping developmental dynamics of autism spectrum disorder mouse models at single-cell resolution,” Institute of Science and Technology Austria, 2025.","ista":"Schwarz LA. 2025. Mapping developmental dynamics of autism spectrum disorder mouse models at single-cell resolution. Institute of Science and Technology Austria.","ama":"Schwarz LA. Mapping developmental dynamics of autism spectrum disorder mouse models at single-cell resolution. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19557\">10.15479/AT-ISTA-19557</a>","apa":"Schwarz, L. A. (2025). <i>Mapping developmental dynamics of autism spectrum disorder mouse models at single-cell resolution</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19557\">https://doi.org/10.15479/AT-ISTA-19557</a>","chicago":"Schwarz, Lena A. “Mapping Developmental Dynamics of Autism Spectrum Disorder Mouse Models at Single-Cell Resolution.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19557\">https://doi.org/10.15479/AT-ISTA-19557</a>.","mla":"Schwarz, Lena A. <i>Mapping Developmental Dynamics of Autism Spectrum Disorder Mouse Models at Single-Cell Resolution</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19557\">10.15479/AT-ISTA-19557</a>."},"project":[{"name":"Critical windows and reversibility of ASD associated with mutations in chromatin remodelers","_id":"9B91375C-BA93-11EA-9121-9846C619BF3A","grant_number":"707964"},{"name":"Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders","_id":"34ba8964-11ca-11ed-8bc3-e15864e7e9a6","grant_number":"101044865"},{"_id":"2548AE96-B435-11E9-9278-68D0E5697425","grant_number":"W1232","call_identifier":"FWF","name":"Molecular Drug Targets"}],"oa_version":"Published Version","type":"dissertation","acknowledgement":"The work presented in this doctoral thesis was performed at the Institute of Science\r\nand Technology (ISTA) and financially supported by a European Research Council\r\n(ERC) Consolidator Grant (PR1028ERC02), by SFARI (PR1028SIM02) and by the\r\nAustrian Science Fund (FWF) to Gaia Novarino (PE1028W1232). I am very thankful\r\nto the Doctoral Program “Molecular Drug Targets” (MolTag) for offering me financial\r\nsupport to perform essential experiments during my PhD studies and to participate in\r\ninternational conferences and courses.","_id":"19557","file_date_updated":"2026-03-27T13:15:08Z","date_published":"2025-04-14T00:00:00Z","month":"04","language":[{"iso":"eng"}],"date_updated":"2026-04-14T09:07:14Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"GaNo"}]},{"author":[{"id":"331776E2-F248-11E8-B48F-1D18A9856A87","full_name":"Synak, Peter","first_name":"Peter","last_name":"Synak"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","acknowledged_ssus":[{"_id":"ScienComp"}],"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"8135"},{"id":"17219","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"8384","relation":"part_of_dissertation"}]},"page":"106","article_processing_charge":"No","abstract":[{"text":"This thesis consists of three chapters, each corresponding to one publication. While each of these projects tackles a topic in a different area of research, they all share a common thread in the type of topological structure they handle - a partition of space into volumes separated by interfaces that meet in non-manifold junctions.\r\n\r\nIn Chapter 2, we study clusters of soap bubbles from a simulation perspective. In particular, we develop a surface-only algorithm that couples large scale motion and shape deformation of soap bubble clusters with the small scale evolution of the thin film's thickness, which is responsible for visual phenomena like surface vortices, Newton's interference patterns, capillary waves, and deformation-dependent rupturing of films in a foam. We model film thickness as a reduced degree of freedom in the Navier-Stokes equations and from them derive three sets of equations governing normal and tangential motion of the soap film surface, as well as the evolution of the thin film thickness. We discretize these equations on a non-manifold triangle mesh, extending and adapting operators to handle complex topology. We also present an incompressible fluid solver for 2.5D films and an advection algorithm for convecting fields across non-manifold surface junctions. Our simulations enhance bubble solvers with additional effects caused by convection, rippling, draining, and evaporation of the thin film.\r\n\r\nIn Chapter 3, we introduce a multi-material non-manifold mesh-based surface tracking algorithm that converts mesh defects, such as overlaps, self-intersections, and inversions into topological changes. Our algorithm generalizes prior work on manifold surface tracking with topological changes: it preserves surface features like mesh-based methods, and it robustly handles topological changes like level set methods. Our method also offers improved efficiency and robustness over the state of the art. We demonstrate the effectiveness of the approach on a range of examples, including complex soap film simulations, such as those presented in Chapter 2, but with an order of magnitude more interacting bubbles than what we could achieve before, and Boolean unions of non-manifold meshes consisting of millions of triangles.\r\n\r\nLastly, in Chapter 4, we utilize developments in the theory of random geometric complexes facilitated by observations from Discrete Morse theory. We survey the methods and results obtained with this new approach, and discuss some of its shortcomings. We use simulations to illustrate the results and to form conjectures, getting numerical estimates for combinatorial, topological, and geometric properties of weighted and unweighted Delaunay mosaics, their dual Voronoi tessellations, and the Alpha and Wrap complexes contained in the mosaics.","lang":"eng"}],"publication_status":"published","degree_awarded":"PhD","title":"Methods for fluid simulation, surface tracking, and statistics of non-manifold structures","supervisor":[{"last_name":"Wojtan","first_name":"Christopher J","orcid":"0000-0001-6646-5546","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","full_name":"Wojtan, Christopher J"}],"year":"2025","date_created":"2025-04-29T09:39:34Z","doi":"10.15479/AT-ISTA-19630","publication_identifier":{"issn":["2663-337X"]},"corr_author":"1","file":[{"creator":"cchlebak","file_name":"Thesis_source_Heiss_Synak.zip","content_type":"application/x-zip-compressed","date_created":"2025-04-30T14:02:25Z","date_updated":"2025-04-30T14:02:25Z","file_size":60670543,"checksum":"f00b519c27529daa0c3b2d4102b4fa7b","relation":"source_file","access_level":"closed","file_id":"19633"},{"file_id":"19634","file_size":21319043,"date_updated":"2025-04-30T15:49:16Z","access_level":"open_access","relation":"main_file","checksum":"6e40a2fd3b1b881af1385670854a682e","content_type":"application/pdf","file_name":"Thesis_PDFA_Heiss_Synak.pdf","date_created":"2025-04-30T14:02:42Z","creator":"cchlebak"}],"has_accepted_license":"1","ddc":["519","006"],"oa_version":"Published Version","acknowledgement":"The project in Chapter 2 has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under grant agreement No. 638176. The project in Chapter 3 was funded in part by the European Union (ERC-2021-COG 101045083 CoDiNA). The project in Chapter 4 has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreements No 78818 Alpha and No 638176). It was also partially supported by the DFG Collaborative Research Center TRR 109, 'Discretization in Geometry and Dynamics', through grant no. I02979-N35 of the Austrian Science Fund (FWF). Thank you for providing funds to support my work.","type":"dissertation","_id":"19630","oa":1,"file_date_updated":"2025-04-30T15:49:16Z","language":[{"iso":"eng"}],"month":"04","date_published":"2025-04-29T00:00:00Z","department":[{"_id":"ChWo"},{"_id":"GradSch"}],"publisher":"Institute of Science and Technology Austria","date_updated":"2026-04-16T08:29:34Z","ec_funded":1,"alternative_title":["ISTA Thesis"],"day":"29","status":"public","citation":{"ama":"Synak P. Methods for fluid simulation, surface tracking, and statistics of non-manifold structures. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19630\">10.15479/AT-ISTA-19630</a>","ista":"Synak P. 2025. Methods for fluid simulation, surface tracking, and statistics of non-manifold structures. Institute of Science and Technology Austria.","short":"P. Synak, Methods for Fluid Simulation, Surface Tracking, and Statistics of Non-Manifold Structures, Institute of Science and Technology Austria, 2025.","ieee":"P. Synak, “Methods for fluid simulation, surface tracking, and statistics of non-manifold structures,” Institute of Science and Technology Austria, 2025.","mla":"Synak, Peter. <i>Methods for Fluid Simulation, Surface Tracking, and Statistics of Non-Manifold Structures</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19630\">10.15479/AT-ISTA-19630</a>.","chicago":"Synak, Peter. “Methods for Fluid Simulation, Surface Tracking, and Statistics of Non-Manifold Structures.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19630\">https://doi.org/10.15479/AT-ISTA-19630</a>.","apa":"Synak, P. (2025). <i>Methods for fluid simulation, surface tracking, and statistics of non-manifold structures</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19630\">https://doi.org/10.15479/AT-ISTA-19630</a>"},"project":[{"call_identifier":"H2020","name":"Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large Scales","_id":"2533E772-B435-11E9-9278-68D0E5697425","grant_number":"638176"},{"grant_number":"101045083","_id":"34bc2376-11ca-11ed-8bc3-9a3b3961a088","name":"Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena"},{"grant_number":"788183","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","name":"Alpha Shape Theory Extended","call_identifier":"H2020"},{"name":"Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large Scales","call_identifier":"H2020","grant_number":"638176","_id":"2533E772-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","name":"Persistence and stability of geometric complexes","_id":"2561EBF4-B435-11E9-9278-68D0E5697425","grant_number":"I02979-N35"}]},{"supervisor":[{"last_name":"Chatterjee","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu"}],"degree_awarded":"PhD","title":"Reciprocity and inequality in social dilemmas","article_processing_charge":"No","page":"157","publication_status":"published","abstract":[{"lang":"eng","text":"Cooperation, that is, one person paying a cost for another's benefit, is a fundamental principle without which no form of society could exist. The extent to which humans cooperate with each other is also an essential feature that differentiates them from other animals. Cooperation occurs even in the absence of altruistic motivations, when it is selfishly incentivised by the expectation of a future reward. For example, many economic interactions are well described that way. This kind of cooperation requires that people exhibit reciprocal behaviour that acts as a mechanism that rewards cooperation.\r\nWith game-theoretic models, it is possible to formally study potential such mechanisms and under what conditions they can exist. This thesis contributes to this effort by analysing recently introduced models of cooperation that advance on previous work by taking into account the potential for pre-existing inequality among cooperating individuals as well as the different forms that reciprocity can take.\r\nIndividuals may differ both intrinsically, in their abilities, as well as extrinsically, in the amount of resources they have available. Allowing for such differences in a model of cooperation helps to understand how inequality affects the potential for, and outcomes of, cooperation among unequals. In this thesis, it is shown that in the presence of intrinsic inequality, a similar unequal distribution of resources can increase the potential for cooperation. This effect is stronger the smaller the group is in which cooperation takes place. It is also shown that under particular assumptions, if the unequal members of a group vary the size of their contributions to a cooperative effort over time, they can thereby increase their efficiency and improve the collective outcome.\r\nCooperative behaviour in a two-person interaction can be rewarded either by direct reciprocation whenever the same two people interact again, or indirectly by a third party who observed the interaction. In the latter case of indirect reciprocity, individuals are proximally rewarded by a good reputation, which ultimately translates to being rewarded with cooperative behaviour by others. This mechanism can enable selfishly motivated cooperation even in circumstances where individuals are unlikely to meet again, akin to how money facilitates trade. While these two forms of reciprocity have mostly been studied in isolation, this thesis analyses both direct and indirect reciprocity in a general model in order to compare their relative effectiveness under different circumstances. The contribution of this thesis is an extension of previous work regarding a specific kind of interaction, whose parameters allow for convenient mathematical analysis, to the most general set of possible interactions."}],"related_material":{"record":[{"status":"public","id":"19843","relation":"part_of_dissertation"},{"id":"15083","relation":"part_of_dissertation","status":"public"},{"id":"19074","relation":"part_of_dissertation","status":"public"}]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","author":[{"first_name":"Valentin","last_name":"Hübner","full_name":"Hübner, Valentin","orcid":"0009-0001-5009-4987","id":"2c8aa207-dc7d-11ea-9b2f-f22972ecd910"}],"OA_place":"publisher","has_accepted_license":"1","ddc":["519"],"corr_author":"1","file":[{"date_updated":"2025-06-25T13:38:07Z","file_size":6192760,"relation":"source_file","checksum":"794c02f8c82ca59ba6dda3bd7eed871a","access_level":"closed","file_id":"19905","creator":"vhuebner","content_type":"application/x-xz","file_name":"Thesis Valentin Hübner source.tar.xz","date_created":"2025-06-25T13:38:07Z"},{"creator":"vhuebner","date_created":"2025-07-09T13:37:00Z","content_type":"application/pdf","file_name":"Thesis Valentin Hübner.pdf","access_level":"open_access","checksum":"ac56063d81c81e40322b6ff5a8c4912e","relation":"main_file","date_updated":"2025-07-09T13:37:00Z","file_size":4837864,"file_id":"19976"}],"publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-19903","date_created":"2025-06-25T13:50:10Z","year":"2025","date_published":"2025-06-25T00:00:00Z","language":[{"iso":"eng"}],"month":"06","date_updated":"2026-04-07T12:30:57Z","department":[{"_id":"GradSch"},{"_id":"KrCh"}],"publisher":"Institute of Science and Technology Austria","file_date_updated":"2025-07-09T13:37:00Z","oa":1,"_id":"19903","oa_version":"Published Version","acknowledgement":"The research for this thesis was supported by the European Research Council\r\n(grant agreements No. 863818 and No. 850529), the European Union’s Horizon 2020 research and innovation programme (Marie Skłodowska-Curie grant agreement No. 754411),\r\nthe Austrian Science Fund (grant DOI 10.55776/COE12), the French Agence Nationale\r\nde la Recherche under the Programme d’investissements d’avenir (project reference 17-\r\nEURE-0010) and the Australian Government through the Australian Research Council\r\n(grant No. SR200100005, “Securing Antarctica’s Environmental Future”).","type":"dissertation","citation":{"ista":"Hübner V. 2025. Reciprocity and inequality in social dilemmas. Institute of Science and Technology Austria.","ama":"Hübner V. Reciprocity and inequality in social dilemmas. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19903\">10.15479/AT-ISTA-19903</a>","ieee":"V. Hübner, “Reciprocity and inequality in social dilemmas,” Institute of Science and Technology Austria, 2025.","short":"V. Hübner, Reciprocity and Inequality in Social Dilemmas, Institute of Science and Technology Austria, 2025.","mla":"Hübner, Valentin. <i>Reciprocity and Inequality in Social Dilemmas</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19903\">10.15479/AT-ISTA-19903</a>.","chicago":"Hübner, Valentin. “Reciprocity and Inequality in Social Dilemmas.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19903\">https://doi.org/10.15479/AT-ISTA-19903</a>.","apa":"Hübner, V. (2025). <i>Reciprocity and inequality in social dilemmas</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19903\">https://doi.org/10.15479/AT-ISTA-19903</a>"},"project":[{"_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","grant_number":"863818","call_identifier":"H2020","name":"Formal Methods for Stochastic Models: Algorithms and Applications"},{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}],"alternative_title":["ISTA Thesis"],"status":"public","day":"25","tmp":{"short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"ec_funded":1},{"page":"114","article_processing_charge":"No","abstract":[{"text":"Immune responses depend on the coordinated and efficient migration of leukocytes. These\r\ncells, which are embedded and tightly confined within tissues, must navigate and traverse\r\ndiverse and complex three-dimensional environments. Leukocytes adapt their locomotory\r\nbehavior to the mechanical, geometrical, and biochemical characteristics of their\r\nsurroundings. In low-density environments, where the pore size of the interstitial matrix\r\nallows free passage, these cells position the nucleus directly behind the lamellipodium, the\r\nprotrusive actin structure that forms the leading front of the cell. In this configuration, they\r\nuse the nucleus as a gauge to identify the path of least resistance.\r\nHere, we show that in high-density environments, where the pore size precludes free passage\r\nof the cell body, leukocytes reposition the microtubule-organizing center (MTOC) and\r\nassociated organelles in front of the nucleus. In this configuration, they use actin structures\r\nprotruding orthogonally to the direction of migration in order to open a path for the cell body.\r\nWe identify two distinct actin populations that serve this purpose at different subcellular\r\nlocalizations. At the leading edge, local indentation of the plasma membrane leads to\r\nrecruitment of the Wiskott-Aldrich syndrome protein (WASp), which, via Arp2/3, results in\r\nthe formation of individual actin foci. At the cell body, actin polymerization is triggered by\r\nDOCK8, a Cdc42 exchange factor, resulting in the formation of a central actin pool.\r\nWe demonstrate that the central and peripheral actin pools are functionally communicating\r\nand that depletion of the central actin pool leads to increased actin accumulation at the cell\r\nfront, resulting in excessive extension of the leading edge.","lang":"eng"}],"publication_status":"published","degree_awarded":"PhD","title":"Coordination of protrusive forces in immune cell migration ","supervisor":[{"first_name":"Michael K","last_name":"Sixt","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K"}],"author":[{"last_name":"Dos Reis Rodrigues","first_name":"Patricia","id":"26E95904-5160-11E9-9C0B-C5B0DC97E90F","orcid":"0000-0003-1681-508X","full_name":"Dos Reis Rodrigues, Patricia"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"NanoFab"}],"related_material":{"record":[{"status":"public","id":"10703","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"20082","status":"public"}]},"corr_author":"1","file":[{"file_id":"20232","access_level":"open_access","checksum":"fda8a1070667c3562263f4867609b41b","relation":"main_file","file_size":63885565,"date_updated":"2025-08-27T12:59:10Z","date_created":"2025-08-27T12:59:10Z","content_type":"application/pdf","file_name":"2025_ReisRodrigues_Patricia_Thesis.pdf","success":1,"creator":"prodrigu"},{"date_created":"2025-08-27T13:00:30Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"2025_ReisRodrigues_Patricia_Thesis.docx","creator":"prodrigu","file_id":"20233","checksum":"e8b65affcbce846a926454df4b2867b9","relation":"source_file","access_level":"closed","file_size":50483434,"date_updated":"2025-08-27T13:02:28Z"}],"has_accepted_license":"1","ddc":["570"],"year":"2025","date_created":"2025-08-08T09:18:02Z","doi":"10.15479/AT-ISTA-20149","publication_identifier":{"issn":["2663-337X"]},"oa":1,"file_date_updated":"2025-08-27T13:02:28Z","language":[{"iso":"eng"}],"month":"08","date_published":"2025-08-08T00:00:00Z","department":[{"_id":"GradSch"},{"_id":"MiSi"}],"publisher":"Institute of Science and Technology Austria","date_updated":"2026-04-28T13:26:50Z","oa_version":"Published Version","acknowledgement":"I would like to acknowledge the\r\nfinancial support of the European Research Council through the ERC-SyG grant “Pushing from\r\nwithin: Control of cell shape, integrity and motility by cytoskeletal pushing forces”\r\n(01071793), which made this research possible. ","type":"dissertation","_id":"20149","citation":{"chicago":"Dos Reis Rodrigues, Patricia. “Coordination of Protrusive Forces in Immune Cell Migration .” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20149\">https://doi.org/10.15479/AT-ISTA-20149</a>.","apa":"Dos Reis Rodrigues, P. (2025). <i>Coordination of protrusive forces in immune cell migration </i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20149\">https://doi.org/10.15479/AT-ISTA-20149</a>","mla":"Dos Reis Rodrigues, Patricia. <i>Coordination of Protrusive Forces in Immune Cell Migration </i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20149\">10.15479/AT-ISTA-20149</a>.","short":"P. Dos Reis Rodrigues, Coordination of Protrusive Forces in Immune Cell Migration , Institute of Science and Technology Austria, 2025.","ieee":"P. Dos Reis Rodrigues, “Coordination of protrusive forces in immune cell migration ,” Institute of Science and Technology Austria, 2025.","ama":"Dos Reis Rodrigues P. Coordination of protrusive forces in immune cell migration . 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20149\">10.15479/AT-ISTA-20149</a>","ista":"Dos Reis Rodrigues P. 2025. Coordination of protrusive forces in immune cell migration . Institute of Science and Technology Austria."},"project":[{"name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces","grant_number":"101071793","_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd"}],"tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"alternative_title":["ISTA Thesis"],"status":"public","day":"08"},{"OA_place":"publisher","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","author":[{"last_name":"Vorlaufer","first_name":"Jakob","id":"937696FA-C996-11E9-8C7C-CF13E6697425","orcid":"0009-0000-7590-3501","full_name":"Vorlaufer, Jakob"}],"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"19795"}]},"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"EM-Fac"},{"_id":"Bio"}],"publication_status":"published","abstract":[{"lang":"eng","text":"The internal structure of biomolecules and their organization in higher-order arrangements are key factors governing the working principles of biological systems. Bioimaging has successfully revealed arrangements across relevant spatial scales. For example, cryo-electron tomography has become widely used for analyzing biomolecular structures in situ due to its comprehensive structural visualization of near-natively preserved samples, and its capability of sub-nm resolution via averaging. However, the identification of molecules within crowded cellular environments is often hindered by low contrast. Fluorescence microscopy, on the other hand, routinely visualizes specifically labeled targets at single-molecule contrast against essentially zero background. Moreover, it provides comparatively high throughput and is amenable to multiplexing. Due to this complementarity, combining datasets from both modalities acquired on the same region via correlative light and electron microscopy can reveal novel types of information. \r\nThe spatial scale at which information can be extracted depends on imaging resolution and correlation accuracy. Since diffraction of light limits the resolution of conventional fluorescence microscopy to few hundreds of nanometers, reaching the full potential of correlative imaging requires super-resolution approaches. Performing imaging at cryogenic temperature preserves structures in a near-native state and minimizes distortions between the fluorescence and the electron microscopy datasets. Implementations of this concept have achieved correlation on the scale of cellular organelles or bacterial domains.\r\nWe have worked towards pushing correlative imaging to the single-molecule scale by improving cryo-super-resolution microscopy, and devising a refined image correlation workflow. As part of this project, I constructed a microscopy setup and adopted it for super-resolution fluorescence microscopy at room temperature and cryogenic conditions. I explored different cryo-stages and acquisition strategies. Specifically, I developed a new scheme for correcting sample drift, thus increasing mechanical stability during microscopy acquisitions.\r\n"}],"article_processing_charge":"No","page":"107","supervisor":[{"id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8559-3973","full_name":"Danzl, Johann G","first_name":"Johann G","last_name":"Danzl"}],"title":"Construction of a cryo-super-resolution microscope to guide in situ structure analysis","degree_awarded":"PhD","date_created":"2025-08-22T08:12:55Z","year":"2025","publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-20206","file":[{"file_id":"20228","date_updated":"2025-08-25T13:49:55Z","file_size":39735535,"access_level":"closed","relation":"source_file","checksum":"191db3367c19c9b32b65f4bc3a7c19de","file_name":"2025_Vorlaufer_Jakob_Thesis.docx","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2025-08-25T13:49:55Z","creator":"jvorlauf"},{"access_level":"open_access","relation":"main_file","checksum":"104400e6036921569610230c1d4899dc","file_size":10947446,"date_updated":"2025-08-25T13:49:56Z","file_id":"20229","success":1,"creator":"jvorlauf","date_created":"2025-08-25T13:49:56Z","file_name":"2025_Vorlaufer_Jakob_Thesis.pdf","content_type":"application/pdf"}],"corr_author":"1","ddc":["621","535"],"has_accepted_license":"1","acknowledgement":"The project was supported by CZI grant DAF2021-234754 and grant\r\nDOI: https://doi.org/10.37921/812628ebpcwg from the Chan Zuckerberg Initiative DAF, an\r\nadvised fund of Silicon Valley Community Foundation (funder\r\nDOI: https://doi.org/10.13039/100014989), as well as internal grants from ISTA’s Equipment\r\nInvestment Committee and Interdisciplinary Project Committee. ","type":"dissertation","oa_version":"Published Version","_id":"20206","file_date_updated":"2025-08-25T13:49:56Z","oa":1,"date_updated":"2026-04-07T11:48:07Z","department":[{"_id":"GradSch"},{"_id":"JoDa"}],"publisher":"Institute of Science and Technology Austria","date_published":"2025-08-25T00:00:00Z","language":[{"iso":"eng"}],"month":"08","tmp":{"short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"day":"25","status":"public","alternative_title":["ISTA Thesis"],"project":[{"name":"CryoMinflux-guided in-situ molecular census and structure determination","grant_number":"CZI01","_id":"62909c6f-2b32-11ec-9570-e1476aab5308"}],"citation":{"short":"J. Vorlaufer, Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis, Institute of Science and Technology Austria, 2025.","ieee":"J. Vorlaufer, “Construction of a cryo-super-resolution microscope to guide in situ structure analysis,” Institute of Science and Technology Austria, 2025.","ama":"Vorlaufer J. Construction of a cryo-super-resolution microscope to guide in situ structure analysis. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20206\">10.15479/AT-ISTA-20206</a>","ista":"Vorlaufer J. 2025. Construction of a cryo-super-resolution microscope to guide in situ structure analysis. Institute of Science and Technology Austria.","chicago":"Vorlaufer, Jakob. “Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20206\">https://doi.org/10.15479/AT-ISTA-20206</a>.","apa":"Vorlaufer, J. (2025). <i>Construction of a cryo-super-resolution microscope to guide in situ structure analysis</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20206\">https://doi.org/10.15479/AT-ISTA-20206</a>","mla":"Vorlaufer, Jakob. <i>Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20206\">10.15479/AT-ISTA-20206</a>."}},{"corr_author":"1","file":[{"creator":"dbabic","date_created":"2025-09-24T13:43:14Z","file_name":"2025_David_Babic_Thesis.pdf","content_type":"application/pdf","relation":"main_file","checksum":"5ecf274281a54a41e0288bc79edf7492","access_level":"closed","date_updated":"2025-09-26T07:29:11Z","embargo_to":"open_access","file_size":7501548,"file_id":"20388","embargo":"2026-09-25"},{"access_level":"closed","checksum":"2703e548390de0a1af7a707137e8ab3b","relation":"source_file","date_updated":"2025-09-26T07:29:11Z","file_size":23206052,"file_id":"20389","creator":"dbabic","date_created":"2025-09-24T13:43:14Z","file_name":"Thesis_Babic_draft.docx","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document"}],"has_accepted_license":"1","ddc":["580"],"year":"2025","date_created":"2025-09-17T13:28:01Z","publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-20362","page":"116","article_processing_charge":"No","publication_status":"published","degree_awarded":"PhD","title":"Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana","supervisor":[{"last_name":"Friml","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"},{"first_name":"Eva","last_name":"Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","full_name":"Benková, Eva"}],"author":[{"first_name":"David","last_name":"Babic","full_name":"Babic, David","id":"db566d23-f6e0-11ea-865d-e6f270e968e7"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"20187"}]},"citation":{"apa":"Babic, D. (2025). <i>Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20362\">https://doi.org/10.15479/AT-ISTA-20362</a>","chicago":"Babic, David. “Mechanisms of Auxin-Mediated Early Embryogenesis in Arabidopsis Thaliana.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20362\">https://doi.org/10.15479/AT-ISTA-20362</a>.","mla":"Babic, David. <i>Mechanisms of Auxin-Mediated Early Embryogenesis in Arabidopsis Thaliana</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20362\">10.15479/AT-ISTA-20362</a>.","short":"D. Babic, Mechanisms of Auxin-Mediated Early Embryogenesis in Arabidopsis Thaliana, Institute of Science and Technology Austria, 2025.","ieee":"D. Babic, “Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana,” Institute of Science and Technology Austria, 2025.","ama":"Babic D. Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20362\">10.15479/AT-ISTA-20362</a>","ista":"Babic D. 2025. Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana. Institute of Science and Technology Austria."},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"alternative_title":["ISTA Thesis"],"status":"public","day":"18","file_date_updated":"2025-09-26T07:29:11Z","month":"09","language":[{"iso":"eng"}],"date_published":"2025-09-18T00:00:00Z","department":[{"_id":"GradSch"},{"_id":"JiFr"},{"_id":"EvBe"}],"publisher":"Institute of Science and Technology Austria","date_updated":"2026-04-07T11:52:02Z","oa_version":"Published Version","type":"dissertation","_id":"20362"},{"type":"dissertation","oa_version":"Published Version","_id":"20393","file_date_updated":"2025-10-02T07:51:21Z","date_updated":"2026-04-14T09:50:52Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"AnKi"},{"_id":"EdHa"}],"date_published":"2025-09-24T00:00:00Z","language":[{"iso":"eng"}],"month":"09","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"status":"public","day":"24","alternative_title":["ISTA Thesis"],"citation":{"mla":"Kishi, Kasumi. <i>Regulation of Notochord and Floor Plate Size during Mouse Development</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20393\">10.15479/AT-ISTA-20393</a>.","chicago":"Kishi, Kasumi. “Regulation of Notochord and Floor Plate Size during Mouse Development.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20393\">https://doi.org/10.15479/AT-ISTA-20393</a>.","apa":"Kishi, K. (2025). <i>Regulation of notochord and floor plate size during mouse development</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20393\">https://doi.org/10.15479/AT-ISTA-20393</a>","ista":"Kishi K. 2025. Regulation of notochord and floor plate size during mouse development. Institute of Science and Technology Austria.","ama":"Kishi K. Regulation of notochord and floor plate size during mouse development. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20393\">10.15479/AT-ISTA-20393</a>","short":"K. Kishi, Regulation of Notochord and Floor Plate Size during Mouse Development, Institute of Science and Technology Austria, 2025.","ieee":"K. Kishi, “Regulation of notochord and floor plate size during mouse development,” Institute of Science and Technology Austria, 2025."},"OA_place":"publisher","author":[{"last_name":"Kishi","first_name":"Kasumi","id":"3065DFC4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6060-4795","full_name":"Kishi, Kasumi"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","related_material":{"record":[{"relation":"part_of_dissertation","id":"18481","status":"public"}]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"},{"_id":"LifeSc"}],"publication_status":"published","article_processing_charge":"No","page":"102","supervisor":[{"last_name":"Kicheva","first_name":"Anna","full_name":"Kicheva, Anna","orcid":"0000-0003-4509-4998","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hannezo","first_name":"Edouard B","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"}],"title":"Regulation of notochord and floor plate size during mouse development","degree_awarded":"PhD","date_created":"2025-09-25T10:08:10Z","year":"2025","publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-20393","file":[{"file_name":"2025-Kishi-Kasumi-Thesis.zip","content_type":"application/x-zip-compressed","date_created":"2025-09-30T14:33:17Z","creator":"kkishi","file_id":"20413","date_updated":"2025-10-01T11:54:41Z","file_size":41847994,"access_level":"closed","checksum":"6bb5a7ce318dc3f7bd165f2523e77b89","relation":"source_file"},{"checksum":"88349b9177e1dcbe1242cd3884b36fdb","relation":"main_file","access_level":"closed","file_size":55747072,"embargo_to":"open_access","date_updated":"2025-10-02T07:51:21Z","embargo":"2026-09-30","file_id":"20414","creator":"kkishi","date_created":"2025-09-30T14:33:22Z","file_name":"2025-Kishi-Kasumi-Thesis.pdf","content_type":"application/pdf"}],"corr_author":"1","ddc":["570"],"has_accepted_license":"1"},{"month":"10","language":[{"iso":"eng"}],"date_published":"2025-10-01T00:00:00Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"MaIb"}],"date_updated":"2026-04-07T11:52:32Z","file_date_updated":"2025-10-07T08:57:14Z","_id":"20415","oa_version":"Published Version","type":"dissertation","citation":{"ieee":"S. Lee, “Nanoparticle-based precursors toward advanced crystalline inorganic solids,” Institute of Science and Technology Austria, 2025.","short":"S. Lee, Nanoparticle-Based Precursors toward Advanced Crystalline Inorganic Solids, Institute of Science and Technology Austria, 2025.","ama":"Lee S. Nanoparticle-based precursors toward advanced crystalline inorganic solids. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20415\">10.15479/AT-ISTA-20415</a>","ista":"Lee S. 2025. Nanoparticle-based precursors toward advanced crystalline inorganic solids. Institute of Science and Technology Austria.","apa":"Lee, S. (2025). <i>Nanoparticle-based precursors toward advanced crystalline inorganic solids</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20415\">https://doi.org/10.15479/AT-ISTA-20415</a>","chicago":"Lee, Seungho. “Nanoparticle-Based Precursors toward Advanced Crystalline Inorganic Solids.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20415\">https://doi.org/10.15479/AT-ISTA-20415</a>.","mla":"Lee, Seungho. <i>Nanoparticle-Based Precursors toward Advanced Crystalline Inorganic Solids</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20415\">10.15479/AT-ISTA-20415</a>."},"project":[{"_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A","name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery"}],"alternative_title":["ISTA Thesis"],"day":"01","status":"public","degree_awarded":"PhD","title":"Nanoparticle-based precursors toward advanced crystalline inorganic solids","supervisor":[{"id":"43C61214-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5013-2843","full_name":"Ibáñez, Maria","first_name":"Maria","last_name":"Ibáñez"},{"full_name":"Protesescu, Loredana","last_name":"Protesescu","first_name":"Loredana"},{"orcid":"0000-0003-2902-5319","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","full_name":"Freunberger, Stefan Alexander","first_name":"Stefan Alexander","last_name":"Freunberger"}],"page":"144","article_processing_charge":"No","publication_status":"published","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"EM-Fac"}],"related_material":{"record":[{"id":"15357","relation":"part_of_dissertation","status":"public"},{"id":"12237","relation":"part_of_dissertation","status":"public"}]},"author":[{"orcid":"0000-0002-6962-8598","id":"BB243B88-D767-11E9-B658-BC13E6697425","full_name":"Lee, Seungho","first_name":"Seungho","last_name":"Lee"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","has_accepted_license":"1","ddc":["540"],"corr_author":"1","file":[{"file_id":"20420","date_updated":"2025-10-07T08:57:14Z","file_size":88706648,"access_level":"closed","relation":"source_file","checksum":"fa6d5946feb37b678ee1c6dffb4fa167","file_name":"2025_Lee_Seungho_Thesis.docx","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2025-10-03T12:29:43Z","creator":"slee"},{"creator":"slee","file_name":"2025_Lee_Seungho_Thesis__.pdf","content_type":"application/pdf","date_created":"2025-10-03T12:29:25Z","file_size":14587276,"date_updated":"2025-10-03T12:29:25Z","embargo_to":"open_access","access_level":"closed","relation":"main_file","checksum":"c5ba6d464113ad0c5812a9d24b539b86","file_id":"20421","embargo":"2026-10-03"}],"publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-20415","year":"2025","date_created":"2025-10-01T09:04:00Z"},{"citation":{"ieee":"F. E. Miteva, “The role of cyclooxygenase 1 on microglial response to inflammatory stressors,” Institute of Science and Technology Austria, 2025.","short":"F.E. Miteva, The Role of Cyclooxygenase 1 on Microglial Response to Inflammatory Stressors, Institute of Science and Technology Austria, 2025.","ista":"Miteva FE. 2025. The role of cyclooxygenase 1 on microglial response to inflammatory stressors. Institute of Science and Technology Austria.","ama":"Miteva FE. The role of cyclooxygenase 1 on microglial response to inflammatory stressors. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20467\">10.15479/AT-ISTA-20467</a>","apa":"Miteva, F. E. (2025). <i>The role of cyclooxygenase 1 on microglial response to inflammatory stressors</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20467\">https://doi.org/10.15479/AT-ISTA-20467</a>","chicago":"Miteva, Florianne E. “The Role of Cyclooxygenase 1 on Microglial Response to Inflammatory Stressors.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20467\">https://doi.org/10.15479/AT-ISTA-20467</a>.","mla":"Miteva, Florianne E. <i>The Role of Cyclooxygenase 1 on Microglial Response to Inflammatory Stressors</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20467\">10.15479/AT-ISTA-20467</a>."},"project":[{"name":"Dissecting the morpho-functional relationship of microglia","_id":"7be82147-9f16-11ee-852c-f44682d73140","grant_number":"P37131"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"alternative_title":["ISTA Thesis"],"status":"public","day":"14","file_date_updated":"2025-10-23T11:33:06Z","language":[{"iso":"eng"}],"month":"10","date_published":"2025-10-14T00:00:00Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"SaSi"}],"date_updated":"2026-05-20T06:37:12Z","oa_version":"Published Version","type":"dissertation","acknowledgement":"The work presented in this Thesis was carried out at the Institute of Science and Technology\r\nAustria (ISTA), and was supported by the Austrian Science Fund (FWF) [10.55776/P37131].\r\nI would like to thank the Scientific Service Units (SSU) of ISTA for the provided resources,\r\nspecifically the Imaging and Optics Facility (IOF), the Lab Support Facility (LSF), and the\r\nPre-Clinical Facility (PCF) team, specifically Sonja Haslinger, Claudia Gold, and Michael\r\nSchunn, for mouse colony management and support. 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Elegans Nervous System</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20485\">10.15479/AT-ISTA-20485</a>.","apa":"Misova, M. (2025). <i>Dissecting gap junction biology using the C. elegans nervous system</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20485\">https://doi.org/10.15479/AT-ISTA-20485</a>","chicago":"Misova, Michaela. “Dissecting Gap Junction Biology Using the C. Elegans Nervous System.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20485\">https://doi.org/10.15479/AT-ISTA-20485</a>.","ama":"Misova M. Dissecting gap junction biology using the C. elegans nervous system. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20485\">10.15479/AT-ISTA-20485</a>","ista":"Misova M. 2025. Dissecting gap junction biology using the C. elegans nervous system. Institute of Science and Technology Austria.","ieee":"M. Misova, “Dissecting gap junction biology using the C. elegans nervous system,” Institute of Science and Technology Austria, 2025.","short":"M. Misova, Dissecting Gap Junction Biology Using the C. Elegans Nervous System, Institute of Science and Technology Austria, 2025."},"project":[{"name":"International IST Doctoral Program","call_identifier":"H2020","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"alternative_title":["ISTA Thesis"],"status":"public","day":"23","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ec_funded":1,"date_published":"2025-10-23T00:00:00Z","language":[{"iso":"eng"}],"month":"10","date_updated":"2026-04-07T11:54:00Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"MaDe"}],"file_date_updated":"2025-11-06T11:08:06Z","_id":"20485","oa_version":"Published Version","acknowledgement":"I would also like to acknowledge the funding that I received from the European Union’s\r\nHorizon 2020 research and Innovation programme under the Marie Sklodowska-Curie\r\nGrant Agreement No. 665385. This work would not have been possible without the contribution and support of people\r\nbehind the scientific service units at ISTA: the Life Science Facility (LSF), Imaging and\r\nOptics Facility (IOF), the Bioinformatics Unit, Protein Services Unit and\r\nElectrophysiology Unit. I would also like to recognize the work of people at the Vienna\r\nBiocenter (VBC) Mass Spectrometry Facility, particularly Markus Hartl and WeiQiang\r\nChen. ","type":"dissertation"},{"oa_version":"Published Version","acknowledgement":"Projects contained in this thesis were financially supported in part by the\r\nEuropean Research Council with grants 1. ERC Consolidator Grant 101045083 CoDiNA,\r\nand 2. the European Union’s Horizon 2020 research and innovation programme under grant\r\nagreement No. 638176.","type":"dissertation","_id":"20551","file_date_updated":"2025-11-10T08:45:05Z","oa":1,"date_published":"2025-10-31T00:00:00Z","language":[{"iso":"eng"}],"month":"10","date_updated":"2026-04-07T12:02:23Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"ChWo"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ec_funded":1,"alternative_title":["ISTA Thesis"],"day":"31","status":"public","citation":{"apa":"Ishida, S. (2025). <i>Symplectic-prequantum structures and dynamics on the codimension-2 shape space</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20551\">https://doi.org/10.15479/AT-ISTA-20551</a>","chicago":"Ishida, Sadashige. “Symplectic-Prequantum Structures and Dynamics on the Codimension-2 Shape Space.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20551\">https://doi.org/10.15479/AT-ISTA-20551</a>.","mla":"Ishida, Sadashige. <i>Symplectic-Prequantum Structures and Dynamics on the Codimension-2 Shape Space</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20551\">10.15479/AT-ISTA-20551</a>.","short":"S. Ishida, Symplectic-Prequantum Structures and Dynamics on the Codimension-2 Shape Space, Institute of Science and Technology Austria, 2025.","ieee":"S. Ishida, “Symplectic-prequantum structures and dynamics on the codimension-2 shape space,” Institute of Science and Technology Austria, 2025.","ama":"Ishida S. Symplectic-prequantum structures and dynamics on the codimension-2 shape space. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20551\">10.15479/AT-ISTA-20551</a>","ista":"Ishida S. 2025. Symplectic-prequantum structures and dynamics on the codimension-2 shape space. Institute of Science and Technology Austria."},"project":[{"call_identifier":"H2020","name":"Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large Scales","_id":"2533E772-B435-11E9-9278-68D0E5697425","grant_number":"638176"},{"name":"Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena","grant_number":"101045083","_id":"34bc2376-11ca-11ed-8bc3-9a3b3961a088"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","author":[{"id":"6F7C4B96-A8E9-11E9-A7CA-09ECE5697425","orcid":"0000-0002-3121-3100","full_name":"Ishida, Sadashige","last_name":"Ishida","first_name":"Sadashige"}],"OA_place":"publisher","acknowledged_ssus":[{"_id":"CampIT"}],"related_material":{"record":[{"relation":"part_of_dissertation","id":"12846","status":"public"},{"id":"12431","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"17361"},{"status":"public","id":"20580","relation":"part_of_dissertation"}]},"article_processing_charge":"No","page":"141","publication_status":"published","abstract":[{"lang":"eng","text":"The space of codimension-2 shapes, such as curves in 3D and surfaces in 4D, is an infinite-dimensional manifold. This thesis explores geometric structures and dynamics on this space, with emphasis on their implications for physics, particularly hydrodynamics.\r\n\r\nOur investigation ranges from theoretical studies of infinite-dimensional symplectic and prequantum geometry to numerical computation of the time evolution of shapes. The thesis presents four main contributions.\r\n\r\nIn the first part, we introduce implicit representations of codimension-2 shapes using a class of complex-valued functions, and prove that the space of these implicit representations forms a prequantum bundle over the codimension-2 shape space. This reveals a new geometric interpretation of the canonical symplectic structure on the codimension-2 shape space.\r\n\r\nIn the second part, we use implicit representations to develop a simulation method for the dynamics of space curves. To handle chaotic systems such as vortex filaments in hydrodynamics, we exploit the infinite degrees of freedom, hidden in both the configuration and dynamics of implicit representations.\r\n\r\nIn the third part, we introduce new symplectic structures on the space of space curves, which generalize the only previously known symplectic structure on this space, allowing for new Hamiltonian dynamics of space curves.\r\n\r\nIn the fourth part, we apply a symplectic viewpoint to a differential geometric problem with practical applications. We derive a new area formula for spherical polygons via prequantization. "}],"supervisor":[{"last_name":"Wojtan","first_name":"Christopher J","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6646-5546","full_name":"Wojtan, Christopher J"},{"full_name":"Chern, Albert","last_name":"Chern","first_name":"Albert"}],"degree_awarded":"PhD","title":"Symplectic-prequantum structures and dynamics on the codimension-2 shape space","date_created":"2025-10-27T10:28:52Z","year":"2025","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-070-1"]},"doi":"10.15479/AT-ISTA-20551","corr_author":"1","file":[{"file_id":"20583","date_updated":"2025-11-01T18:26:14Z","file_size":72487812,"access_level":"open_access","checksum":"4eef80afcb67691cbb6549c4756fa534","relation":"source_file","content_type":"application/zip","file_name":"Thesis_tex.zip","date_created":"2025-11-01T18:26:14Z","creator":"sishida"},{"file_size":8945141,"date_updated":"2025-11-10T08:45:05Z","checksum":"1e5a557900bf2dce01966b211b15d0fe","relation":"main_file","access_level":"open_access","file_id":"20623","creator":"sishida","success":1,"file_name":"Thesis_Sadashige_Ishida_PDFA.pdf","content_type":"application/pdf","date_created":"2025-11-10T08:45:05Z"}],"has_accepted_license":"1","ddc":["516"]},{"OA_place":"publisher","author":[{"full_name":"Riabov, Volodymyr","id":"1949f904-edfb-11eb-afb5-e2dfddabb93b","last_name":"Riabov","first_name":"Volodymyr"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","related_material":{"record":[{"relation":"part_of_dissertation","id":"20322","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"18764"},{"status":"public","relation":"part_of_dissertation","id":"13317"},{"id":"19368","relation":"part_of_dissertation","status":"deleted"},{"status":"public","id":"18554","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"20576"},{"id":"17174","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"19547"},{"status":"public","relation":"part_of_dissertation","id":"19598"}]},"publication_status":"published","abstract":[{"lang":"eng","text":"This thesis deals with eigenvalue and eigenvector universality results for random matrix ensembles equipped with non-trivial spatial structure. We consider both mean-field models with a general variance profile (Wigner-type matrices) and correlation structure (correlated matrices) among the entries, as well as non-mean-field random band matrices with bandwidth W >> N^(1/2).\r\n\r\nTo extract the universal properties of random matrix spectra and eigenvectors, we obtain concentration estimates for their resolvent, the local laws, which generalize the celebrated Wigner semicircle law for a broad class of random matrices to much finer spectral scales. The local laws hold for both a single resolvent as well as for products of multiple resolvents, known as resolvent chains, and express the remarkable approximately-deterministic behavior of these objects down to the microscopic scale.\r\n\r\nOur primary tool for establishing the local laws is the dynamical Zigzag strategy, which we develop in the setting of spatially-inhomogeneous random matrices. Our proof method systematically addresses the challenges arising from non-trivial spatial structures and is robust to all types of singularities in the spectrum, as we demonstrate in the correlated setting. Furthermore, we incorporate the analysis of the deterministic resolvent chain approximations into the dynamical framework of the Zigzag strategy, synthesizing a unified toolkit for establishing multi-resolvent local laws.\r\n\r\nUsing these methods, we prove complete eigenvector delocalization, the Eigenstate Thermalization Hypothesis, and Wigner-Dyson universality in the bulk for random band matrices down to the optimal bandwidth W >> N^(1/2). For mean-field ensembles, we establish universality of local eigenvalue statistics at the cups for random matrices with correlated entries, and the Eigenstate Thermalization Hypothesis for Wigner-type matrices in the bulk of the spectrum.\r\n\r\nFinally, this thesis also contains other applications of the multi-resolvent local laws to spatially-inhomogeneous random matrices, obtained prior to the development of the Zigzag strategy. In particular, we provide a complete analysis of mesoscopic linear-eigenvalue statistics of Wigner-type matrices in all spectral regimes, including the novel cusps, and rigorously establish the prethermalization phenomenon for deformed Wigner matrices.\r\n\r\nThe main body of this thesis consists of seven research papers (listed on page xi), each presented in a separate chapter with its own introduction and all relevant context, suitable to be read independently. We ask the reader’s indulgence for the repetitions in the historical overviews and other minor redundancies that remain among the chapters as a result. The overall Introduction, preceding the chapters, provides a condensed, informal summary of the main ideas and concepts at the core of these works.\r\n"}],"article_processing_charge":"No","page":"436","supervisor":[{"last_name":"Erdös","first_name":"László","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603"}],"degree_awarded":"PhD","title":"Universality in random matrices with spatial structure","date_created":"2025-10-29T19:12:24Z","year":"2025","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-064-0"]},"doi":"10.15479/AT-ISTA-20575","file":[{"file_name":"riabov_thesis-pdfa.pdf","content_type":"application/pdf","date_created":"2025-10-29T18:53:59Z","success":1,"creator":"vriabov","file_id":"20577","file_size":7536583,"date_updated":"2025-10-29T18:53:59Z","access_level":"open_access","relation":"main_file","checksum":"6a0487b2b66bb35d44b394756d44b8b4"},{"creator":"vriabov","content_type":"application/x-zip-compressed","file_name":"manuscript.zip","date_created":"2025-10-29T18:54:53Z","file_size":17841612,"date_updated":"2025-10-29T18:54:53Z","checksum":"224efda6bf9864d296a1e5e0124c1e8f","relation":"source_file","access_level":"closed","file_id":"20578"}],"corr_author":"1","ddc":["515","519"],"has_accepted_license":"1","type":"dissertation","acknowledgement":"The work comprising this thesis was supported by the ERC Advanced Grant \"RMTBeyond\"\r\nNo.101020331 awarded to my advisor.","oa_version":"Published Version","_id":"20575","file_date_updated":"2025-10-29T18:54:53Z","oa":1,"date_updated":"2026-04-07T12:32:20Z","department":[{"_id":"GradSch"},{"_id":"LaEr"}],"publisher":"Institute of Science and Technology Austria","date_published":"2025-11-03T00:00:00Z","month":"11","language":[{"iso":"eng"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ec_funded":1,"status":"public","day":"3","alternative_title":["ISTA Thesis"],"project":[{"_id":"62796744-2b32-11ec-9570-940b20777f1d","grant_number":"101020331","call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta"}],"citation":{"mla":"Riabov, Volodymyr. <i>Universality in Random Matrices with Spatial Structure</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20575\">10.15479/AT-ISTA-20575</a>.","chicago":"Riabov, Volodymyr. “Universality in Random Matrices with Spatial Structure.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20575\">https://doi.org/10.15479/AT-ISTA-20575</a>.","apa":"Riabov, V. (2025). <i>Universality in random matrices with spatial structure</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20575\">https://doi.org/10.15479/AT-ISTA-20575</a>","ista":"Riabov V. 2025. Universality in random matrices with spatial structure. Institute of Science and Technology Austria.","ama":"Riabov V. Universality in random matrices with spatial structure. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20575\">10.15479/AT-ISTA-20575</a>","short":"V. Riabov, Universality in Random Matrices with Spatial Structure, Institute of Science and Technology Austria, 2025.","ieee":"V. Riabov, “Universality in random matrices with spatial structure,” Institute of Science and Technology Austria, 2025."}},{"file":[{"date_updated":"2025-12-11T11:18:37Z","file_size":78207207,"access_level":"closed","checksum":"71e0fdf4619b0d70d03657ad7348137d","relation":"source_file","file_id":"20793","creator":"rcasadop","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"2025_CasadoPolanco_Raquel_Thesis.docx","date_created":"2025-12-11T09:28:09Z"},{"creator":"rcasadop","file_name":"2025_CasadoPolanco_Raquel_Thesis.pdf","content_type":"application/pdf","date_created":"2025-12-11T09:28:04Z","file_size":6261874,"date_updated":"2025-12-11T09:28:04Z","embargo_to":"open_access","access_level":"closed","checksum":"58cf2f25c33567723bc754a019c3e396","relation":"main_file","embargo":"2026-12-01","file_id":"20794"}],"corr_author":"1","ddc":["570"],"has_accepted_license":"1","year":"2025","date_created":"2025-12-09T09:04:18Z","doi":"10.15479/AT-ISTA-20737","publication_identifier":{"isbn":["978-3-99078-072-5"],"issn":["2663-337X"]},"publication_status":"published","page":"133","article_processing_charge":"No","degree_awarded":"PhD","title":"Role of NOTCH signaling in radial glial progenitor lineage progression","keyword":["NOTCH","radial glial progenitor","lineage progression","cortical development"],"supervisor":[{"last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon"}],"OA_place":"publisher","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","author":[{"first_name":"Raquel","last_name":"Casado Polanco","orcid":"0000-0001-8293-4568","id":"15240fc1-dbcd-11ea-9d1d-ac5a786425fd","full_name":"Casado Polanco, Raquel"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"project":[{"_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E","grant_number":"F7805","name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression"}],"citation":{"mla":"Casado Polanco, Raquel. <i>Role of NOTCH Signaling in Radial Glial Progenitor Lineage Progression</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20737\">10.15479/AT-ISTA-20737</a>.","apa":"Casado Polanco, R. (2025). <i>Role of NOTCH signaling in radial glial progenitor lineage progression</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20737\">https://doi.org/10.15479/AT-ISTA-20737</a>","chicago":"Casado Polanco, Raquel. “Role of NOTCH Signaling in Radial Glial Progenitor Lineage Progression.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20737\">https://doi.org/10.15479/AT-ISTA-20737</a>.","ista":"Casado Polanco R. 2025. Role of NOTCH signaling in radial glial progenitor lineage progression. Institute of Science and Technology Austria.","ama":"Casado Polanco R. Role of NOTCH signaling in radial glial progenitor lineage progression. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20737\">10.15479/AT-ISTA-20737</a>","short":"R. Casado Polanco, Role of NOTCH Signaling in Radial Glial Progenitor Lineage Progression, Institute of Science and Technology Austria, 2025.","ieee":"R. Casado Polanco, “Role of NOTCH signaling in radial glial progenitor lineage progression,” Institute of Science and Technology Austria, 2025."},"status":"public","day":"09","alternative_title":["ISTA Thesis"],"file_date_updated":"2025-12-11T11:18:37Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"SiHi"}],"date_updated":"2026-04-14T08:16:58Z","language":[{"iso":"eng"}],"month":"12","date_published":"2025-12-09T00:00:00Z","type":"dissertation","acknowledgement":"I also want to thank ISTA and the Austrian Science Fund FWF SFB F78 (F7805) for financially\r\nsupporting my research.","oa_version":"Published Version","_id":"20737"},{"ddc":["572"],"has_accepted_license":"1","file":[{"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"2025_marko_kojic_thesis.docx","date_created":"2025-12-10T13:09:58Z","creator":"mkojic","file_id":"20774","file_size":142876975,"date_updated":"2025-12-10T13:09:58Z","checksum":"a3643d07e93134b2490a566b02a4517d","relation":"source_file","access_level":"closed"},{"date_updated":"2025-12-10T13:09:38Z","file_size":8597045,"checksum":"0a096f0af6ccc3a8329d5bb8797ad533","relation":"main_file","access_level":"open_access","file_id":"20775","creator":"mkojic","success":1,"file_name":"2025_marko_kojic_thesis.pdf","content_type":"application/pdf","date_created":"2025-12-10T13:09:38Z"}],"corr_author":"1","doi":"10.15479/AT-ISTA-20741","publication_identifier":{"isbn":["978-3-99078-073-2"],"issn":["2663-337X"]},"date_created":"2025-12-09T13:08:11Z","year":"2025","supervisor":[{"last_name":"Loose","first_name":"Martin","full_name":"Loose, Martin","orcid":"0000-0001-7309-9724","id":"462D4284-F248-11E8-B48F-1D18A9856A87"}],"title":"Towards understanding the assembly mechanisms of the Z-ring in Archaea and Bacteria","degree_awarded":"PhD","publication_status":"published","abstract":[{"text":"Life on Earth emerged when biomacromolecules were membrane-enclosed in a confined space where many essential chemical reactions were more likely to happen and thereby accelerate evolution. These kinds of membranes separated internal reactions from the outside chaos while staying flexible so that those primordial cells can move, adopt their shape and, most importantly, propagate. Such membrane plasticity still remains a defining feature of all modern cell types. This remarkable ability to change their shape is most prominently observed during their propagation (i.e., cell division). Throughout division, a cell undergoes drastic change in its shape, usually at the middle of the cell, pulling the two opposite membrane sides inward, closer to each other, and, finally, culminating in pinching off to separate the cell into two daughter cells. To achieve this, a cell needs to employ a protein machinery, usually termed divisome, that can coordinate all necessary intracellular processes with membrane remodelling and synthesis of other extracellular structures that decorate a cell. The focus of this dissertation is a membrane-remodelling FtsZ system that is present across all domains of life. FtsZ forms filaments that further self-organize into ring-like structures at the cell septum and together with other division proteins perform cell envelope synthesis and constriction. However, there are still knowledge gaps in our mechanistic understanding of division in both archaea and bacteria. My work presented in this dissertation centres around a simple yet not well understood question: How is the divisome positioned correctly at the mid-cell? To achieve the proper positioning, the divisome needs to (i) be recruited to the mid-cell and (ii) localized orthogonally to the long cell axis. I tackle these processes in two different systems by applying an in vitro biochemical bottom-up reconstitution approach. I use purified components of Haloferax volcanii and Escherichia coli divisome to explore how divisome is recruited to the mid-cell in archaea and how the Z-ring positions orthogonally to the long cell axis in bacteria, respectively. \r\n\r\nFirstly, I collaborate with archaeal cell and structural biologists to explore the assembly of early division proteins in two FtsZ-containing archaeon H. volcanii, a standard model system for understudied archaeal organisms. I particularly address the hierarchy of interactions that allow a tripartite complex formation (SepF-CdpB1-CdpB2) and how the hierarchy of interactions ultimately leads to the recruitment of FtsZ filaments to the septum. This part of work has been published in (Nußbaum et al., 2024). In collaboration with evolutionary biologists, I shed light on ancient features that archaeal divisome has retained to this day and also speculate on a property that it might have lost during the course of evolution. \r\n\r\nNext, I switch my attention to E. coli divisome. Particularly, I address the FtsZ’s intrinsic biophysical property that drives the Z-ring diameter, and thereby the perpendicular orientation of the Z-ring to the long cell axis based on suggested membrane curvature sensing mechanism (Vanhille-Campos et al., 2024). This property allows formation of different Z-ring diameters that match the variety of cell diameters present in prokaryotes. The results showcase that the distribution of charged amino acids in the intrinsically disordered linker at the C-terminus (CTL) of FtsZ is the major determining factor of Z-ring diameter with inter-CTL interactions as an underlying mechanism. \r\n\r\nFinally, I thoroughly explain the methodology I used to address the abovementioned projects, and I finish with a discussion on how early archaeal divisome assembly and curvature sensing mechanism in bacteria, at first sight unrelated topics, are interconnected and important groundwork for both fundamental and translational research. ","lang":"eng"}],"article_processing_charge":"No","related_material":{"record":[{"id":"15118","relation":"part_of_dissertation","status":"public"}]},"acknowledged_ssus":[{"_id":"Bio"}],"OA_place":"publisher","author":[{"last_name":"Kojic","first_name":"Marko","full_name":"Kojic, Marko","orcid":"0000-0001-7244-8128","id":"73e7ecd4-dc85-11ea-9058-88a16394b160"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","citation":{"ista":"Kojic M. 2025. Towards understanding the assembly mechanisms of the Z-ring in Archaea and Bacteria. Institute of Science and Technology Austria.","ama":"Kojic M. Towards understanding the assembly mechanisms of the Z-ring in Archaea and Bacteria. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20741\">10.15479/AT-ISTA-20741</a>","ieee":"M. Kojic, “Towards understanding the assembly mechanisms of the Z-ring in Archaea and Bacteria,” Institute of Science and Technology Austria, 2025.","short":"M. Kojic, Towards Understanding the Assembly Mechanisms of the Z-Ring in Archaea and Bacteria, Institute of Science and Technology Austria, 2025.","mla":"Kojic, Marko. <i>Towards Understanding the Assembly Mechanisms of the Z-Ring in Archaea and Bacteria</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20741\">10.15479/AT-ISTA-20741</a>.","chicago":"Kojic, Marko. “Towards Understanding the Assembly Mechanisms of the Z-Ring in Archaea and Bacteria.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20741\">https://doi.org/10.15479/AT-ISTA-20741</a>.","apa":"Kojic, M. (2025). <i>Towards understanding the assembly mechanisms of the Z-ring in Archaea and Bacteria</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20741\">https://doi.org/10.15479/AT-ISTA-20741</a>"},"status":"public","day":"09","alternative_title":["ISTA Thesis"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_updated":"2026-04-07T12:27:58Z","department":[{"_id":"GradSch"},{"_id":"MaLo"}],"publisher":"Institute of Science and Technology Austria","date_published":"2025-12-09T00:00:00Z","language":[{"iso":"eng"}],"month":"12","file_date_updated":"2025-12-10T13:09:58Z","oa":1,"_id":"20741","type":"dissertation","oa_version":"Published Version"},{"has_accepted_license":"1","ddc":["580"],"corr_author":"1","file":[{"creator":"cgiannin","file_name":"2025_Giannini_Caterina_Thesis...pdf","content_type":"application/pdf","date_created":"2025-09-24T14:46:34Z","date_updated":"2025-09-30T14:31:29Z","embargo_to":"open_access","file_size":14278965,"access_level":"closed","checksum":"536ba1701453b0b2346be14c046b2911","relation":"main_file","embargo":"2026-09-30","file_id":"20390"},{"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"2025_Giannini_Caterina_Thesis...docx","date_created":"2025-09-24T14:46:35Z","creator":"cgiannin","file_id":"20391","date_updated":"2025-09-24T14:46:35Z","file_size":24499022,"checksum":"192f55262f2da2ea0a59d9c23a1b8573","relation":"source_file","access_level":"closed"}],"doi":"10.15479/AT-ISTA-20364","publication_identifier":{"issn":["2663-337X"]},"date_created":"2025-09-19T12:23:38Z","year":"2025","supervisor":[{"orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","first_name":"Jiří","last_name":"Friml"}],"keyword":["Auxin Signaling","Plant Development"],"degree_awarded":"PhD","title":"Nuclear and cell surface auxin signaling in A. thaliana developmental transitions","article_processing_charge":"No","page":"151","publication_status":"published","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"12291"},{"id":"19399","relation":"part_of_dissertation","status":"public"}]},"author":[{"last_name":"Giannini","first_name":"Caterina","full_name":"Giannini, Caterina","id":"e3fdddd5-f6e0-11ea-865d-ca99ee6367f4"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","citation":{"mla":"Giannini, Caterina. <i>Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20364\">10.15479/AT-ISTA-20364</a>.","apa":"Giannini, C. (2025). <i>Nuclear and cell surface auxin signaling in A. thaliana developmental transitions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20364\">https://doi.org/10.15479/AT-ISTA-20364</a>","chicago":"Giannini, Caterina. “Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20364\">https://doi.org/10.15479/AT-ISTA-20364</a>.","ista":"Giannini C. 2025. Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. Institute of Science and Technology Austria.","ama":"Giannini C. Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20364\">10.15479/AT-ISTA-20364</a>","short":"C. Giannini, Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions, Institute of Science and Technology Austria, 2025.","ieee":"C. Giannini, “Nuclear and cell surface auxin signaling in A. thaliana developmental transitions,” Institute of Science and Technology Austria, 2025."},"alternative_title":["ISTA Thesis"],"status":"public","day":"19","date_published":"2025-09-19T00:00:00Z","month":"09","language":[{"iso":"eng"}],"date_updated":"2026-07-06T12:51:13Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"JiFr"},{"_id":"MaLo"}],"file_date_updated":"2025-09-30T14:31:29Z","_id":"20364","oa_version":"Published Version","type":"dissertation","acknowledgement":"Plant Facility,\r\nProtein Service Facility"},{"alternative_title":["ISTA Thesis"],"status":"public","day":"12","tmp":{"short":"CC BY-SA (4.0)","name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)","image":"/images/cc_by_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode"},"citation":{"chicago":"Naik, Suyash. “Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20441\">https://doi.org/10.15479/AT-ISTA-20441</a>.","apa":"Naik, S. (2025). <i>Keratins act as global coordinators of tissue spreading through mechanosensitive feedback</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20441\">https://doi.org/10.15479/AT-ISTA-20441</a>","mla":"Naik, Suyash. <i>Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20441\">10.15479/AT-ISTA-20441</a>.","ieee":"S. Naik, “Keratins act as global coordinators of tissue spreading through mechanosensitive feedback,” Institute of Science and Technology Austria, 2025.","short":"S. Naik, Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback, Institute of Science and Technology Austria, 2025.","ista":"Naik S. 2025. Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. Institute of Science and Technology Austria.","ama":"Naik S. Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20441\">10.15479/AT-ISTA-20441</a>"},"project":[{"name":"Keratins in epithelial tissue spreading","grant_number":"PAT 5044023","_id":"8f060199-16d5-11f0-9cad-f3253b266c46"},{"grant_number":"W 1250-B20","_id":"25AA5F24-B435-11E9-9278-68D0E5697425","name":"Nano-Analytics of Cellular Systems","call_identifier":"FWF"}],"_id":"20441","oa_version":"Published Version","type":"dissertation","acknowledgement":"I would also like to thank the LSF and Cryo facility at ISTA, which have been helpful in my\r\nexperiments. I would also like to acknowledge FWF, grant DOI 10.55776/PAT5044023 and JKU Nanocell grant DOI \r\n10.55776/W1250 for providing funding for my PhD research. EMBO and FWF for providing funding for travel grants to attend conferences.","month":"10","language":[{"iso":"eng"}],"date_published":"2025-10-12T00:00:00Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"CaHe"},{"_id":"EdHa"}],"date_updated":"2026-07-06T12:51:41Z","oa":1,"file_date_updated":"2025-10-28T13:10:26Z","doi":"10.15479/AT-ISTA-20441","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-069-5"]},"year":"2025","date_created":"2025-10-10T14:58:30Z","has_accepted_license":"1","ddc":["596","597","532"],"corr_author":"1","file":[{"file_name":"Thesis_PDFA_.pdf","content_type":"application/pdf","date_created":"2025-10-28T13:10:08Z","success":1,"creator":"snaik","file_id":"20567","date_updated":"2025-10-28T13:10:08Z","file_size":6846189,"access_level":"open_access","relation":"main_file","checksum":"2892f04d4a5c18677871c3e06ac1244a"},{"creator":"snaik","file_name":"Thesis.zip","content_type":"application/zip","date_created":"2025-10-28T13:10:26Z","file_size":8839300,"date_updated":"2025-10-28T13:10:26Z","checksum":"15934d4465cd0e9b7c32678da9a33a2f","relation":"source_file","access_level":"open_access","file_id":"20568"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"related_material":{"record":[{"id":"20465","relation":"part_of_dissertation","status":"public"}]},"author":[{"last_name":"Naik","first_name":"Suyash","orcid":"0000-0001-8421-5508","id":"2C0B105C-F248-11E8-B48F-1D18A9856A87","full_name":"Naik, Suyash"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","degree_awarded":"PhD","title":"Keratins act as global coordinators of tissue spreading through mechanosensitive feedback","supervisor":[{"full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","last_name":"Heisenberg"},{"first_name":"Edouard B","last_name":"Hannezo","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"}],"page":"105","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Epithelial spreading plays a pivotal role in the development of organisms especially those\r\nsuch as zebrafish which require the epithelial enveloping layer (EVL) to spread to cover the\r\nsubstantial yolk surface during gastrulation. Epiboly requires the transition of the epithelium\r\nwith cuboidal cells to form a thin, flat squamous epithelial sheet. During this transition, the\r\ncells show tissue-scale mechanosensation with mechanisms such as direct mechanical control\r\nover the axis of cell division.\r\nCytoskeletal intermediate filaments play a crucial role in vertebrate cells, not only facilitating\r\nmechanical stability but also helping facilitate the mechanosensitive response of the cell.\r\nMechanosenstivity displayed by intermediate filaments is due not just to their interesting\r\nphysical properties but also to their interactions with other cytoskeletal elements such as actin\r\nand microtubules. Keratin is the predominant intermediate filament expressed in the EVL.\r\nIt expresses concomitantly with the gastrulation movements of the developing embryo. Our\r\nwork focuses on understanding the role and dynamics of the keratin cytoskeletal network in\r\nmodulating the physical aspects of EVL spreading. We demonstrated with the combination of\r\nphysical characterisation and manipulations of the EVL, utilising a variety of biophysical tools\r\nand microscopy, the mechanistic role of keratin in tissue spreading.\r\nGenerating novel genetic morphants and mutants, we probe the effect that the loss of the\r\nkeratin network has on the physiology of the epithelium and the developing embryo. We\r\nshow that the changing organisation of the keratin network is important for changing EVL\r\nphysical properties as the stress imposed on the EVL increases during epiboly. By modelling\r\nthe epithelium, we study how the mechanical heterogeneity in an epithelium can feed back into\r\na mechanical loop to the maturation of the keratin network and hence affect the mechanics\r\nof the epithelium. However, unlike what would be predicted by the effect of intermediate\r\nfilaments in acting as a security belt and increasing the resistance of the epithelium, we observe\r\nthat loss of keratin leads to a delay in the EVL movement. Using both local aspirations of the\r\nYSL and EVL ablations, we demonstrate the mechanistic facilitation of actin mechanosensation\r\nin a keratin-dependent manner.\r\nFurthermore, using chemical inhibitors of microtubule polymerisation, we provide insight into\r\nthe mechanisms underlying the organisation and distribution of keratin. Interestingly, the\r\nphenotype observed upon this loss of microtubules shows that keratins interact with the nucleus\r\nthrough microtubular interactions. Together with these diverse observations, we describe\r\nthe mechanosensory feedback between resilience and that is critical for uniform and robust\r\nspreading of the epithelium."}],"publication_status":"published"},{"year":"2025","date_created":"2025-04-04T07:48:24Z","publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-19478","corr_author":"1","file":[{"date_updated":"2025-04-08T08:22:37Z","file_size":16344814,"access_level":"closed","checksum":"b154973663a1bba505683faab7ae5ead","relation":"source_file","file_id":"19526","creator":"hchen","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"Thesis_0403_Huihuang.docx","date_created":"2025-04-08T08:00:07Z"},{"embargo":"2026-10-08","file_id":"19527","embargo_to":"local","date_updated":"2025-04-09T13:53:38Z","file_size":8482147,"checksum":"0099565f024388830c125ec17375c1a0","relation":"main_file","access_level":"closed","content_type":"application/pdf","file_name":"Thesis_0406_PDFA_Huihuang_1.pdf","date_created":"2025-04-08T08:00:06Z","creator":"hchen"}],"has_accepted_license":"1","ddc":["580"],"author":[{"id":"83c96512-15b2-11ec-abd3-b7eede36184f","full_name":"Chen, Huihuang","last_name":"Chen","first_name":"Huihuang"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"related_material":{"record":[{"id":"19421","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"13212"}]},"page":"118","article_processing_charge":"No","publication_status":"published","title":"The cAMP second messenger in auxin signalling","degree_awarded":"PhD","supervisor":[{"full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","first_name":"Jiří","last_name":"Friml"}],"ec_funded":1,"alternative_title":["ISTA Thesis"],"day":"04","status":"public","citation":{"mla":"Chen, Huihuang. <i>The CAMP Second Messenger in Auxin Signalling</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19478\">10.15479/AT-ISTA-19478</a>.","apa":"Chen, H. (2025). <i>The cAMP second messenger in auxin signalling</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19478\">https://doi.org/10.15479/AT-ISTA-19478</a>","chicago":"Chen, Huihuang. “The CAMP Second Messenger in Auxin Signalling.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19478\">https://doi.org/10.15479/AT-ISTA-19478</a>.","ama":"Chen H. The cAMP second messenger in auxin signalling. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19478\">10.15479/AT-ISTA-19478</a>","ista":"Chen H. 2025. The cAMP second messenger in auxin signalling. Institute of Science and Technology Austria.","ieee":"H. Chen, “The cAMP second messenger in auxin signalling,” Institute of Science and Technology Austria, 2025.","short":"H. Chen, The CAMP Second Messenger in Auxin Signalling, Institute of Science and Technology Austria, 2025."},"project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020","grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425"},{"name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6","grant_number":"P37051"},{"name":"Cyclic nucleotides as second messengers in plants","_id":"8f347782-16d5-11f0-9cad-8c19706ee739","grant_number":"101142681"}],"oa_version":"Published Version","acknowledgement":"This project was funded by the European Research Council Advanced Grant (ETAP-742985),\r\nEuropean Research Council (ERC; 101142681 CYNIPS), Austrian Science Fund (FWF; P\r\n37051-B).","type":"dissertation","_id":"19478","file_date_updated":"2025-04-09T13:53:38Z","month":"04","language":[{"iso":"eng"}],"date_published":"2025-04-04T00:00:00Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"JiFr"}],"date_updated":"2026-07-06T12:58:58Z"},{"status":"public","day":"31","alternative_title":["ISTA Thesis"],"tmp":{"short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"citation":{"short":"C. Hoffmann, Theory and Applications of Verifiable Delay Functions, Institute of Science and Technology Austria, 2025.","ieee":"C. Hoffmann, “Theory and applications of verifiable delay functions,” Institute of Science and Technology Austria, 2025.","ista":"Hoffmann C. 2025. Theory and applications of verifiable delay functions. Institute of Science and Technology Austria.","ama":"Hoffmann C. Theory and applications of verifiable delay functions. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20920\">10.15479/AT-ISTA-20920</a>","apa":"Hoffmann, C. (2025). <i>Theory and applications of verifiable delay functions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20920\">https://doi.org/10.15479/AT-ISTA-20920</a>","chicago":"Hoffmann, Charlotte. “Theory and Applications of Verifiable Delay Functions.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20920\">https://doi.org/10.15479/AT-ISTA-20920</a>.","mla":"Hoffmann, Charlotte. <i>Theory and Applications of Verifiable Delay Functions</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20920\">10.15479/AT-ISTA-20920</a>."},"_id":"20920","type":"dissertation","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"KrPi"}],"date_updated":"2026-07-06T13:15:27Z","language":[{"iso":"eng"}],"month":"12","date_published":"2025-12-31T00:00:00Z","oa":1,"file_date_updated":"2026-01-02T10:39:26Z","publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-20920","year":"2025","date_created":"2026-01-02T10:46:47Z","ddc":["004"],"has_accepted_license":"1","file":[{"date_created":"2026-01-02T10:39:16Z","file_name":"2025_Hoffmann_Charlotte_Source.zip","content_type":"application/x-zip-compressed","creator":"choffman","file_id":"20921","relation":"source_file","checksum":"8a099fbf54963bd0be38f7ce73658682","access_level":"closed","date_updated":"2026-01-02T10:39:16Z","file_size":8355494},{"file_id":"20922","access_level":"open_access","checksum":"9521c07bfb2bb5b14a49c09fcfc96474","relation":"main_file","date_updated":"2026-01-02T10:39:26Z","file_size":2258804,"date_created":"2026-01-02T10:39:26Z","file_name":"2025_Hoffmann_Charlotte_Thesis.pdf","content_type":"application/pdf","success":1,"creator":"choffman"}],"corr_author":"1","related_material":{"record":[{"status":"public","id":"13143","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"12176","status":"public"},{"relation":"earlier_version","id":"20556","status":"public"},{"id":"19778","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"20701","relation":"part_of_dissertation"}]},"OA_place":"publisher","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","author":[{"first_name":"Charlotte","last_name":"Hoffmann","full_name":"Hoffmann, Charlotte","orcid":"0000-0003-2027-5549","id":"0f78d746-dc7d-11ea-9b2f-83f92091afe7"}],"degree_awarded":"PhD","title":"Theory and applications of verifiable delay functions","supervisor":[{"orcid":"0000-0002-9139-1654","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","full_name":"Pietrzak, Krzysztof Z","last_name":"Pietrzak","first_name":"Krzysztof Z"}],"abstract":[{"text":"Verifiable Delay Functions (VDFs) introduced by Boneh et al. (CRYPTO'18) are functions that require a prescribed number of sequential steps T to evaluate, yet their output can be verified in time much faster than T. Since their introduction, VDFs have gained a lot of attention due to their applications in blockchain protocols, randomness beacons, timestamping and deniability. This thesis explores the theory and applications of VDFs, focusing on enhancing their soundness, efficiency and practicality.\r\n\r\nThe only practical VDFs known to date are based on repeated squaring in hidden order groups. Consider the function VDF(x,T)=x^(2^T).\r\nThe iterated squaring assumption states that, for a random group element x, the result of VDF cannot be computed significantly faster than performing T sequential squarings if the group order is unknown. To make the result verifiable a prover can compute a proof of exponentiation (PoE) \\pi. Given \\pi, the output of VDF can be verified in time much less than T.\r\n\r\nWe first present new constructions of statistically sound proofs of exponentiation, which are an important building block in the construction of SNARKs (Succinct Non-Interactive Argument of Knowledge). Statistical soundness means that the proofs remain secure against computationally unbounded adversaries, in particular, it remains secure even when the group order is known. We thereby address limitations in previous PoE protocols which either required (non-standard) hardness assumptions or a lot of parallel repetitions. Our construction significantly reduces the proof size of statistically sound PoEs that allow for a structured exponent, which leads to better efficiency of SNARKs and other applications.\r\n\r\nSecondly, we introduce improved batching techniques for PoEs, which allow multiple proofs to be aggregated and verified with minimal overhead. These protocols optimize communication and computation complexity in large-scale blockchain environments and enable scalable remote benchmarking of parallel computation resources.\r\n\r\nWe then construct VDFs with enhanced properties such as zero-knowledge and watermarkability. It was shown by Arun, Bonneau and Clark (ASIACRYPT'22) that these features enable new cryptographic primitives called short-lived proofs and signatures. The validity of such proofs and signatures expires after a predefined amount of time T, i.e., they are deniable after time T. Our constructions improve upon the constructions by Arun, Bonneau and Clark in several dimensions (faster forging times, arguably weaker assumptions).\r\n\r\nFinally, we apply PoEs in the realm of primality testing, providing cryptographically sound proofs of non-primality for large Proth numbers. This work gives a surprising application of VDFs in the area of computational number theory.\r\n\r\nTogether, our contributions advance both the theoretical foundations and the real-world usability of VDFs in general and in particular of PoEs, making them more adaptable and secure for current and emerging cryptographic applications.","lang":"eng"}],"publication_status":"published","page":"116","article_processing_charge":"No"},{"publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-20556","year":"2025","date_created":"2025-10-27T14:16:56Z","has_accepted_license":"1","ddc":["004"],"corr_author":"1","file":[{"checksum":"1fffa4e2c33dd0b9f883d615504a2858","relation":"main_file","access_level":"closed","file_size":2259304,"date_updated":"2026-01-08T14:11:39Z","file_id":"20573","creator":"choffman","date_created":"2025-10-28T14:33:03Z","content_type":"application/pdf","file_name":"2025_Hoffmann_Charlotte_Thesis.pdf"},{"file_id":"20574","access_level":"closed","checksum":"076ea98a1f0a86c3bbc990b6b9460dc2","relation":"source_file","date_updated":"2025-11-11T09:34:54Z","file_size":9987633,"date_created":"2025-10-28T14:35:06Z","content_type":"application/x-zip-compressed","file_name":"2025_Hoffmann_Charlotte_Source.zip","creator":"choffman"}],"related_material":{"record":[{"id":"13143","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"12176","relation":"part_of_dissertation"},{"relation":"later_version","id":"20920","status":"public"},{"status":"public","id":"19778","relation":"part_of_dissertation"},{"id":"20701","relation":"part_of_dissertation","status":"public"}]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","author":[{"full_name":"Hoffmann, Charlotte","orcid":"0000-0003-2027-5549","id":"0f78d746-dc7d-11ea-9b2f-83f92091afe7","first_name":"Charlotte","last_name":"Hoffmann"}],"OA_place":"publisher","title":"Theory and applications of verifiable delay functions","degree_awarded":"PhD","supervisor":[{"full_name":"Pietrzak, Krzysztof Z","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9139-1654","first_name":"Krzysztof Z","last_name":"Pietrzak"}],"page":"116","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Verifiable Delay Functions (VDFs) introduced by Boneh et al. (CRYPTO'18) are functions that require a prescribed number of sequential steps T to evaluate, yet their output can be verified in time much faster than T. Since their introduction, VDFs have gained a lot of attention due to their applications in blockchain protocols, randomness beacons, timestamping and deniability. This thesis explores the theory and applications of VDFs, focusing on enhancing their soundness, efficiency and practicality.\r\n\r\nThe only practical VDFs known to date are based on repeated squaring in hidden order groups. Consider the function VDF(x,T)=x^(2^T).\r\nThe iterated squaring assumption states that, for a random group element x, the result of VDF cannot be computed significantly faster than performing T sequential squarings if the group order is unknown. To make the result verifiable a prover can compute a proof of exponentiation (PoE) \\pi. Given \\pi, the output of VDF can be verified in time much less than T.\r\n\r\nWe first present new constructions of statistically sound proofs of exponentiation, which are an important building block in the construction of SNARKs (Succinct Non-Interactive Argument of Knowledge). Statistical soundness means that the proofs remain secure against computationally unbounded adversaries, in particular, it remains secure even when the group order is known. We thereby address limitations in previous PoE protocols which either required (non-standard) hardness assumptions or a lot of parallel repetitions. Our construction significantly reduces the proof size of statistically sound PoEs that allow for a structured exponent, which leads to better efficiency of SNARKs and other applications.\r\n\r\nSecondly, we introduce improved batching techniques for PoEs, which allow multiple proofs to be aggregated and verified with minimal overhead. These protocols optimize communication and computation complexity in large-scale blockchain environments and enable scalable remote benchmarking of parallel computation resources.\r\n\r\nWe then construct VDFs with enhanced properties such as zero-knowledge and watermarkability. It was shown by Arun, Bonneau and Clark (ASIACRYPT'22) that these features enable new cryptographic primitives called short-lived proofs and signatures. The validity of such proofs and signatures expires after a predefined amount of time T, i.e., they are deniable after time T. Our constructions improve upon the constructions by Arun, Bonneau and Clark in several dimensions (faster forging times, arguably weaker assumptions).\r\n\r\nFinally, we apply PoEs in the realm of primality testing, providing cryptographically sound proofs of non-primality for large Proth numbers. This work gives a surprising application of VDFs in the area of computational number theory.\r\n\r\nTogether, our contributions advance both the theoretical foundations and the real-world usability of VDFs in general and in particular of PoEs, making them more adaptable and secure for current and emerging cryptographic applications."}],"publication_status":"published","alternative_title":["ISTA Thesis"],"status":"public","day":"31","tmp":{"short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"citation":{"ieee":"C. Hoffmann, “Theory and applications of verifiable delay functions,” Institute of Science and Technology Austria, 2025.","short":"C. Hoffmann, Theory and Applications of Verifiable Delay Functions, Institute of Science and Technology Austria, 2025.","ama":"Hoffmann C. Theory and applications of verifiable delay functions. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20556\">10.15479/AT-ISTA-20556</a>","ista":"Hoffmann C. 2025. Theory and applications of verifiable delay functions. Institute of Science and Technology Austria.","chicago":"Hoffmann, Charlotte. “Theory and Applications of Verifiable Delay Functions.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20556\">https://doi.org/10.15479/AT-ISTA-20556</a>.","apa":"Hoffmann, C. (2025). <i>Theory and applications of verifiable delay functions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20556\">https://doi.org/10.15479/AT-ISTA-20556</a>","mla":"Hoffmann, Charlotte. <i>Theory and Applications of Verifiable Delay Functions</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20556\">10.15479/AT-ISTA-20556</a>."},"_id":"20556","oa_version":"Published Version","type":"dissertation","month":"10","language":[{"iso":"eng"}],"date_published":"2025-10-31T00:00:00Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"KrPi"}],"date_updated":"2026-07-06T13:15:27Z","file_date_updated":"2026-01-08T14:11:39Z"}]