--- OA_place: repository _id: '21360' acknowledged_ssus: - _id: LifeSc - _id: Bio acknowledgement: "I would like to acknowledge the Austrian Academy of Sciences (ÖAW) and European\r\nResearch Executive Agency (REA) for funding my research (DOC ÖAW Fellowship\r\n26130, Horizon Europe BOLERO Project 101060393). " alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Stefan full_name: Riegler, Stefan id: FF6018E0-D806-11E9-8E43-0B14E6697425 last_name: Riegler orcid: 0000-0003-3413-1343 citation: ama: 'Riegler S. Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species. 2026. doi:10.15479/AT-ISTA-21360' apa: 'Riegler, S. (2026). Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21360' chicago: 'Riegler, Stefan. “Root System Plasticity under Nutrient Limitation : Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21360.' ieee: 'S. Riegler, “Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species,” Institute of Science and Technology Austria, 2026.' ista: 'Riegler S. 2026. Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species. Institute of Science and Technology Austria.' mla: 'Riegler, Stefan. Root System Plasticity under Nutrient Limitation : Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21360.' short: 'S. Riegler, Root System Plasticity under Nutrient Limitation : Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species, Institute of Science and Technology Austria, 2026.' corr_author: '1' date_created: 2026-02-27T09:08:14Z date_published: 2026-02-26T00:00:00Z date_updated: 2026-03-09T12:20:56Z day: '26' ddc: - '570' - '575' - '583' degree_awarded: PhD department: - _id: GradSch - _id: EvBe doi: 10.15479/AT-ISTA-21360 file: - access_level: closed checksum: 2f1f44e8536c2538f94a440217452c9f content_type: application/x-zip-compressed creator: sriegler date_created: 2026-03-02T10:59:50Z date_updated: 2026-03-02T10:59:50Z file_id: '21386' file_name: 2026_Riegler_Stefan_Thesis.zip file_size: 31430022 relation: source_file - access_level: closed checksum: 2e8dc39640bc26ae5684c944c619719b content_type: application/pdf creator: sriegler date_created: 2026-03-02T10:59:49Z date_updated: 2026-03-02T10:59:49Z embargo: 2027-02-27 embargo_to: open_access file_id: '21387' file_name: 2026_Riegler_Stefan_Thesis.pdf file_size: 11635090 relation: main_file file_date_updated: 2026-03-02T10:59:50Z has_accepted_license: '1' language: - iso: eng license: https://creativecommons.org/licenses/by-sa/4.0/ month: '02' oa_version: Published Version page: '185' project: - _id: 34afa094-11ca-11ed-8bc3-a375845a59fb grant_number: '101060393' name: Breeding for coffee and cocoa root resilience in low input farming systems based on improved rootstocks publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '21363' relation: research_data status: public status: public supervisor: - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 title: 'Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea species' tmp: image: /images/cc_by_sa.png legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0) short: CC BY-SA (4.0) type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2026' ... --- OA_place: repository _id: '21423' acknowledged_ssus: - _id: ScienComp acknowledgement: "Finally, I gratefully acknowledge funding from the DOC Fellowship of the Austrian Academy\r\nof Sciences (OeAW): grant agreement 26360." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Zuzana full_name: Dunajova, Zuzana id: 4B39F286-F248-11E8-B48F-1D18A9856A87 last_name: Dunajova citation: ama: Dunajova Z. Geometry-driven self-organization of migrating cells and chiral filaments. 2026. doi:10.15479/AT-ISTA-21423 apa: Dunajova, Z. (2026). Geometry-driven self-organization of migrating cells and chiral filaments. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21423 chicago: Dunajova, Zuzana. “Geometry-Driven Self-Organization of Migrating Cells and Chiral Filaments.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21423. ieee: Z. Dunajova, “Geometry-driven self-organization of migrating cells and chiral filaments,” Institute of Science and Technology Austria, 2026. ista: Dunajova Z. 2026. Geometry-driven self-organization of migrating cells and chiral filaments. Institute of Science and Technology Austria. mla: Dunajova, Zuzana. Geometry-Driven Self-Organization of Migrating Cells and Chiral Filaments. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21423. short: Z. Dunajova, Geometry-Driven Self-Organization of Migrating Cells and Chiral Filaments, Institute of Science and Technology Austria, 2026. corr_author: '1' date_created: 2026-03-11T08:30:49Z date_published: 2026-03-11T00:00:00Z date_updated: 2026-03-18T14:11:35Z day: '11' ddc: - '539' - '570' degree_awarded: PhD department: - _id: GradSch - _id: EdHa doi: 10.15479/AT-ISTA-21423 file: - access_level: closed checksum: 47ce6a48a0c63f28eca6e64c9ffd2c84 content_type: application/pdf creator: zdunajov date_created: 2026-03-12T20:38:52Z date_updated: 2026-03-12T20:38:52Z embargo: 2026-09-11 embargo_to: open_access file_id: '21446' file_name: 2026_Dunajova_Zuzana_Thesis_pdfA.pdf file_size: 14662770 relation: main_file - access_level: closed checksum: 5dec5afdffd47c2b0b162d0fe1bed925 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: zdunajov date_created: 2026-03-12T20:40:18Z date_updated: 2026-03-13T11:19:21Z file_id: '21447' file_name: Thesis-Dunajova_source_file.docx file_size: 32961408 relation: source_file file_date_updated: 2026-03-13T11:19:21Z has_accepted_license: '1' language: - iso: eng license: https://creativecommons.org/licenses/by-nc-sa/4.0/ month: '03' oa_version: Published Version page: '110' project: - _id: 34d75525-11ca-11ed-8bc3-89b6307fee9d grant_number: '26360' name: Motile active matter models of migrating cells and chiral filaments publication_identifier: isbn: - 978-3-99078-076-3 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '13314' relation: part_of_dissertation status: public - id: '13116' relation: research_data status: public - id: '21427' relation: part_of_dissertation status: public - id: '21439' relation: research_data status: public status: public supervisor: - first_name: Edouard B full_name: Hannezo, Edouard B id: 3A9DB764-F248-11E8-B48F-1D18A9856A87 last_name: Hannezo orcid: 0000-0001-6005-1561 title: Geometry-driven self-organization of migrating cells and chiral filaments tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2026' ... --- OA_place: repository _id: '21393' abstract: - lang: eng text: "This thesis documents a voyage towards truth and beauty via formal verification of theorems. To this end, we develop libraries in Lean 4 that present definitions and results from diverse areas of MathematiCS (i.e., Mathematics and Computer Science). The aim is to create code that is understandable, believable, useful, and elegant. The code should stand for itself as much as possible without a need for documentation; however, this text redundantly documents our code artifacts and provides additional context that isn’t present in the code. This thesis is written for readers who know Lean 4 but are not familiar with any of the topics presented. We manifest truth and beauty in three formalized areas of MathematiCS.\r\n\r\nWe formalize general grammars in Lean 4 and use grammars to show closure of the class of type-0 languages under four operations; union, reversal, concatenation, and the Kleene star.\r\n\r\nOur second stop is the theory of optimization. Farkas established that a system of linear inequalities has a solution if and only if we cannot obtain a contradiction by taking a linear combination of the inequalities. We state and formally prove several Farkas-like theorems over linearly ordered fields in Lean 4. Furthermore, we extend duality theory to the case when some coefficients are allowed to take “infinite values”. Additionally, we develop the basics of the theory of optimization in terms of the framework called General-Valued Constraint Satisfaction Problems, and we prove that, if a Rational-Valued Constraint Satisfaction Problem template has symmetric fractional polymorphisms of all arities, then its basic LP relaxation is tight.\r\n\r\nOur third stop is matroid theory. Seymour’s decomposition theorem is a hallmark result in matroid theory, presenting a structural characterization of the class of regular matroids. We aim to formally verify Seymour’s theorem in Lean 4. First, we build a library for working with totally unimodular matrices. We define binary matroids and their standard representations, and we prove that they form a matroid in the sense how Mathlib defines matroids. We define regular matroids to be matroids for which there exists a full representation rational matrix that is totally unimodular, and we prove that all regular matroids are binary. We define 1-sum, 2-sum, and 3 sum of binary matroids as specific ways to compose their standard representation matrices. We prove that the 1-sum, the 2-sum, and the 3-sum of regular matroids are a regular matroid, which concludes the composition direction of the Seymour’s theorem. The (more difficult) decomposition direction remains unproved.\r\n\r\nIn the pursuit of truth, we focus on identifying the trusted code in each project and presenting it faithfully. We emphasize the readability and believability of definitions rather than choosing definitions that are easier to work with. In search for beauty, we focus on the philosophical framework of Roger Scruton, who emphasizes that beauty is not a mere decoration but, most importantly, beauty is the means for shaping our place in the world and a source of redemption, where it can be viewed as a substitute for religion." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Martin full_name: Dvorak, Martin id: 40ED02A8-C8B4-11E9-A9C0-453BE6697425 last_name: Dvorak orcid: 0000-0001-5293-214X citation: ama: 'Dvorak M. Pursuit of truth and beauty in Lean 4 : Formally verified theory of grammars, optimization, matroids. 2026. doi:10.15479/AT-ISTA-21393' apa: 'Dvorak, M. (2026). Pursuit of truth and beauty in Lean 4 : Formally verified theory of grammars, optimization, matroids. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21393' chicago: 'Dvorak, Martin. “Pursuit of Truth and Beauty in Lean 4 : Formally Verified Theory of Grammars, Optimization, Matroids.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21393.' ieee: 'M. Dvorak, “Pursuit of truth and beauty in Lean 4 : Formally verified theory of grammars, optimization, matroids,” Institute of Science and Technology Austria, 2026.' ista: 'Dvorak M. 2026. Pursuit of truth and beauty in Lean 4 : Formally verified theory of grammars, optimization, matroids. Institute of Science and Technology Austria.' mla: 'Dvorak, Martin. Pursuit of Truth and Beauty in Lean 4 : Formally Verified Theory of Grammars, Optimization, Matroids. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21393.' short: 'M. Dvorak, Pursuit of Truth and Beauty in Lean 4 : Formally Verified Theory of Grammars, Optimization, Matroids, Institute of Science and Technology Austria, 2026.' corr_author: '1' date_created: 2026-03-04T09:26:46Z date_published: 2026-03-04T00:00:00Z date_updated: 2026-03-27T12:37:00Z day: '04' ddc: - '511' - '000' degree_awarded: PhD department: - _id: GradSch - _id: VlKo doi: 10.15479/AT-ISTA-21393 file: - access_level: open_access checksum: cface6dc18152680962b5361575f6e4f content_type: application/pdf creator: mdvorak date_created: 2026-03-04T08:56:15Z date_updated: 2026-03-04T08:56:15Z file_id: '21394' file_name: 2026_Dvorak_Martin_Thesis.pdf file_size: 1771231 relation: main_file success: 1 - access_level: closed checksum: 290ddfacfb7e07fb07e6f0b334e67c90 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: mdvorak date_created: 2026-03-04T09:03:37Z date_updated: 2026-03-04T09:03:37Z file_id: '21395' file_name: 2026_Dvorak_Martin_Thesis.docx file_size: 864585 relation: source_file file_date_updated: 2026-03-04T09:03:37Z has_accepted_license: '1' language: - iso: eng month: '03' oa: 1 oa_version: Published Version page: '160' publication_identifier: isbn: - 978-3-99078-074-9 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: link: - description: Full version of all definitions, statements, and proofs for Chapter 3.1 (Linear duality) relation: software url: https://github.com/madvorak/duality/tree/v3.5.0 - description: Full version of all definitions, statements, and proofs for Chapter 3.2 (Valued Constraint Satisfaction Problems) relation: software url: https://github.com/madvorak/vcsp/tree/v8.2.0 - description: Full version of all definitions, statements, and proofs for Chapter 4 (Seymour project) relation: software url: https://github.com/Ivan-Sergeyev/seymour/tree/v1.2.0 - description: Full version of all definitions, statements, and proofs for Chapter 5 (Theory of grammars) relation: software url: https://github.com/madvorak/chomsky/tree/v1.2.0 - description: Old version (Lean 3) of the project about grammars relation: software url: https://github.com/madvorak/grammars - description: Demonstration of (minimal) requirements for selected algebraic classes used in my Ph.D. thesis relation: software url: https://github.com/madvorak/preliminaries/blob/main/Preliminaries.lean record: - id: '13120' relation: part_of_dissertation status: public - id: '21398' relation: part_of_dissertation status: public - id: '20071' relation: part_of_dissertation status: public status: public supervisor: - first_name: Vladimir full_name: Kolmogorov, Vladimir id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87 last_name: Kolmogorov - first_name: Jasmin full_name: Blanchette, Jasmin last_name: Blanchette title: 'Pursuit of truth and beauty in Lean 4 : Formally verified theory of grammars, optimization, matroids' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2026' ... --- OA_place: publisher _id: '21198' abstract: - lang: eng text: "In recent years there has been a massive increase in the amount of data generated in a\r\ndecentralized manner. Ever more powerful edge devices, such as smartphones, have become\r\nubiquitous in most societies on earth. Through text typed, photos taken and apps used,\r\nthese devices, which we refer to as clients, generate enormous amounts of high quality and\r\ncomplex data. Moreover, the nature of these devices means the data they generate is often\r\nsensitive and privacy concerns prevent it being gathered and stored in a central location. This\r\npresents a challenge to the modern machine learning paradigm that requires central access\r\nto large amounts of data. Federated learning (FL) has emerged as one of the answers to\r\nthis problem. Rather than bringing the data to the model, FL sends the model to the data.\r\nModel training takes place on device, with periodically synchronized updates, allowing data to\r\nremain locally stored. While this approach offers significant privacy advantages it comes with\r\nits own set of unique challenges. These include: data heterogeneity, the notion that different\r\ndevices generate data in distinct ways which can negatively impact training dynamics; systems\r\nheterogeneity, meaning that different devices may have differing hardware specifications; high\r\ncommunication costs, which are induced by the repeated transferring of models over the\r\nnetwork and low device computational power, which limits the use of larger models on device.\r\nIn this thesis we present a range of methods for federated learning. We focus primarily on\r\nthe challenge of data heterogeneity, though the methods presented are designed to be well\r\nadapted to the other challenges of a federated setting, such as the constraints of limited\r\ncompute and communication overhead. We first present a method for explicitly modeling client\r\ndata heterogeneity. The approach formulates clients as samples from a certain probability\r\ndistribution and infers the parameters of this distribution from the available training clients.\r\nThis learned distribution then represents the heterogeneity present among the clients and can\r\nbe sampled from in order to create new simulated clients that are similar to the real clients we\r\nhave observed so far. Following this we present two methods for directly dealing with data\r\nheterogeneity through personalization. Highly heterogeneous client data distributions can mean\r\nthat learning a single global model becomes suboptimal, and some form of personalization of\r\nmodels to each individual client is required. Our approaches are based around hypernetworks,\r\nwhich we use to generate personalized model parameters without the need for additional\r\ntraining or finetuning. In the first approach we focus on generating full parameterizations of\r\nclient models using learned embeddings of client data and labels, with a hypernetwork located\r\non the central server. In the second approach we address the more challenging scenario where\r\nwe want to generate a personalized model for a client without any label information. The\r\nhypernetwork is trained to generate a low dimensional representation of a client’s personalized\r\nmodel parameters, allowing it to be transferred to and run on the client devices. In our final\r\npresented method, we change our focus and rather than aim to directly address the challenge\r\nof data heterogeneity, we instead ensure we are unaffected by it. This is done in the context\r\nof k-means clustering and we present a method for federated clustering with a focus on added\r\nprivacy guarantees." acknowledged_ssus: - _id: ScienComp acknowledgement: "This research was funded in part by the Austrian Science Fund (FWF)\r\n[10.55776/COE12]. Furthermore, the candidate acknowledges the support from the Scientific\r\nService Units (SSU) of ISTA through resources provided by Scientific Computing (SciComp)." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Jonathan A full_name: Scott, Jonathan A id: e499926b-f6e0-11ea-865d-9c63db0031e8 last_name: Scott citation: ama: Scott JA. Data heterogeneity and personalization in federated learning. 2026. doi:10.15479/AT-ISTA-21198 apa: Scott, J. A. (2026). Data heterogeneity and personalization in federated learning. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21198 chicago: Scott, Jonathan A. “Data Heterogeneity and Personalization in Federated Learning.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21198. ieee: J. A. Scott, “Data heterogeneity and personalization in federated learning,” Institute of Science and Technology Austria, 2026. ista: Scott JA. 2026. Data heterogeneity and personalization in federated learning. Institute of Science and Technology Austria. mla: Scott, Jonathan A. Data Heterogeneity and Personalization in Federated Learning. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21198. short: J.A. Scott, Data Heterogeneity and Personalization in Federated Learning, Institute of Science and Technology Austria, 2026. corr_author: '1' date_created: 2026-02-09T14:59:53Z date_published: 2026-02-09T00:00:00Z date_updated: 2026-04-07T11:46:11Z day: '09' ddc: - '005' degree_awarded: PhD department: - _id: GradSch - _id: ChLa doi: 10.15479/AT-ISTA-21198 file: - access_level: closed checksum: 121c1d968bd86f3630aa7e81d5bbbcb0 content_type: application/zip creator: jscott date_created: 2026-02-17T11:46:22Z date_updated: 2026-02-17T11:46:22Z file_id: '21298' file_name: 2026_Scott_Jonathan_Thesis_Source.zip file_size: 272379252 relation: source_file - access_level: open_access checksum: 6e3e08ba474bbee8511cc8a839ab2077 content_type: application/pdf creator: jscott date_created: 2026-02-27T10:25:41Z date_updated: 2026-02-27T10:25:41Z file_id: '21366' file_name: 2026_Jonathan_Scott_Thesis.pdf file_size: 15220298 relation: main_file success: 1 file_date_updated: 2026-02-27T10:25:41Z has_accepted_license: '1' language: - iso: eng month: '02' oa: 1 oa_version: Published Version page: '158' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '20819' relation: part_of_dissertation status: public - id: '17411' relation: part_of_dissertation status: public - id: '18120' relation: part_of_dissertation status: public - id: '21207' relation: part_of_dissertation status: public status: public supervisor: - first_name: Christoph full_name: Lampert, Christoph id: 40C20FD2-F248-11E8-B48F-1D18A9856A87 last_name: Lampert orcid: 0000-0001-8622-7887 title: Data heterogeneity and personalization in federated learning type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2026' ... --- OA_place: publisher _id: '21021' abstract: - lang: eng text: This thesis examines how geometry and topology intersect in the representation, transformation, and analysis of complex shapes. It considers how continuous manifolds relate to their discrete analogues, how topological structures evolve in persistence vineyards, and how tools from topological data analysis can illuminate problems in mathematical physics. Central to this exploration is the question of how structure, both geometric and topological, persists or changes under approximation, sampling, or deformation. The work develops new approaches to skeletal and grid-based representations of surfaces, reveals the full expressive capacity of persistence vineyards, and applies topological methods to the longstanding problem of equilibria in electrostatic fields. These threads braid together into a broader understanding of how topology and geometry inform one another across theory, computation, and application. acknowledged_ssus: - _id: M-Shop - _id: ScienComp acknowledgement: "The research presented in this thesis was funded by the DFG Collaborative Research\r\nCenter TRR 109, ‘Discretization in Geometry and Dynamics’.\r\n" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Christopher D full_name: Fillmore, Christopher D id: 35638A5C-AAC7-11E9-B0BF-5503E6697425 last_name: Fillmore citation: ama: Fillmore CD. Braiding geometry and topology to study shapes and data. 2026. doi:10.15479/AT-ISTA-21021 apa: Fillmore, C. D. (2026). Braiding geometry and topology to study shapes and data. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21021 chicago: Fillmore, Christopher D. “Braiding Geometry and Topology to Study Shapes and Data.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21021. ieee: C. D. Fillmore, “Braiding geometry and topology to study shapes and data,” Institute of Science and Technology Austria, 2026. ista: Fillmore CD. 2026. Braiding geometry and topology to study shapes and data. Institute of Science and Technology Austria. mla: Fillmore, Christopher D. Braiding Geometry and Topology to Study Shapes and Data. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21021. short: C.D. Fillmore, Braiding Geometry and Topology to Study Shapes and Data, Institute of Science and Technology Austria, 2026. corr_author: '1' date_created: 2026-01-20T21:38:40Z date_published: 2026-01-21T00:00:00Z date_updated: 2026-04-07T11:42:49Z day: '21' ddc: - '514' - '516' degree_awarded: PhD department: - _id: GradSch - _id: HeEd - _id: UlWa doi: 10.15479/AT-ISTA-21021 file: - access_level: open_access checksum: 4c0889130095c31d4e5088c5b8dfd607 content_type: application/pdf creator: cfillmor date_created: 2026-01-26T19:44:46Z date_updated: 2026-01-30T11:40:09Z file_id: '21046' file_name: 2025_Fillmore_Christopher_Thesis.pdf file_size: 55954297 relation: main_file - access_level: closed checksum: d69afb71d82ab98f856886126ee7303a content_type: application/x-zip-compressed creator: cfillmor date_created: 2026-01-26T19:46:20Z date_updated: 2026-01-26T19:46:20Z file_id: '21047' file_name: Thesis.zip file_size: 166080788 relation: source_file file_date_updated: 2026-01-30T11:40:09Z has_accepted_license: '1' language: - iso: eng month: '01' oa: 1 oa_version: Published Version page: '122' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '20260' relation: part_of_dissertation status: public - id: '21050' relation: part_of_dissertation status: public - id: '21051' relation: part_of_dissertation status: public status: public supervisor: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 - first_name: Uli full_name: Wagner, Uli id: 36690CA2-F248-11E8-B48F-1D18A9856A87 last_name: Wagner orcid: 0000-0002-1494-0568 title: Braiding geometry and topology to study shapes and data tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2026' ... --- OA_place: publisher _id: '21651' abstract: - lang: eng text: "Blockchains enable distributed consensus in permissionless settings, where participants\r\nare unknown, dynamically changing, and do not trust each other. While Bitcoin,\r\nbased on Proof-of-Work (PoW), was the first protocol in this model, significant\r\nresearch has focused on permissionless protocols using alternative physical resources,\r\nspecifically Proof-of-Space (PoSpace) and Verifiable Delay Functions (VDFs). This\r\nthesis investigates the theoretical limits and design space of longest-chain protocols in\r\nthe fully permissionless and dynamically available settings using these three resources.\r\nFirst, we address the feasibility of blockchains relying solely on storage as a resource.\r\nWe prove a fundamental impossibility result: there exists no secure longest-chain\r\nprotocol based exclusively on Proof-of-Space in the fully permissionless or dynamically\r\navailable settings. Further, we quantify the adversarial capabilities required to execute\r\na double-spend attack. Our result formally justifies the necessity of coupling PoSpace\r\nwith time-dependent primitives (such as VDFs) or to move to less permissive settings\r\n(quasi-permissionless or permissioned) to ensure security.\r\nSecond, we generalize Nakamoto-like heaviest chain consensus to protocols utilizing\r\ncombinations of multiple physical resources. We analyze chain selection rules governed\r\nby a weight function Γ(S, V,W), which assigns weight to blocks based on recorded\r\nSpace (S), VDF speed (V ), and Work (W). We provide a complete classification\r\nof secure weight functions, proving that a weight function is secure against private\r\ndouble-spend attacks if and only if it is homogeneous in the timed resources (V,W)\r\nand sub-homogeneous in S. This framework unifies existing protocols like Bitcoin and\r\nChia under a single theoretical model and provides a powerful tool for designing new\r\nlongest-chain blockchains from a mix of physical resources." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Mirza Ahad full_name: Baig, Mirza Ahad id: 3EDE6DE4-AA5A-11E9-986D-341CE6697425 last_name: Baig citation: ama: Baig MA. On secure chain selection rules from physical resources in a permissionless setting. 2026. doi:10.15479/AT-ISTA-21651 apa: Baig, M. A. (2026). On secure chain selection rules from physical resources in a permissionless setting. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21651 chicago: Baig, Mirza Ahad. “On Secure Chain Selection Rules from Physical Resources in a Permissionless Setting.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21651. ieee: M. A. Baig, “On secure chain selection rules from physical resources in a permissionless setting,” Institute of Science and Technology Austria, 2026. ista: Baig MA. 2026. On secure chain selection rules from physical resources in a permissionless setting. Institute of Science and Technology Austria. mla: Baig, Mirza Ahad. On Secure Chain Selection Rules from Physical Resources in a Permissionless Setting. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21651. short: M.A. Baig, On Secure Chain Selection Rules from Physical Resources in a Permissionless Setting, Institute of Science and Technology Austria, 2026. corr_author: '1' date_created: 2026-04-02T09:31:34Z date_published: 2026-03-04T00:00:00Z date_updated: 2026-04-15T08:45:19Z day: '04' ddc: - '000' degree_awarded: PhD department: - _id: GradSch - _id: KrPi doi: 10.15479/AT-ISTA-21651 file: - access_level: closed checksum: c3986dba90653dac97adba662ebff238 content_type: application/x-zip-compressed creator: mbaig date_created: 2026-04-03T17:28:48Z date_updated: 2026-04-13T08:24:13Z file_id: '21655' file_name: PhD-Thesis-Mirza-Ahad-Baig - Library Submission.zip file_size: 139353434 relation: source_file - access_level: open_access checksum: 292a5989262521f7c145a109d1f348cb content_type: application/pdf creator: mbaig date_created: 2026-04-03T17:29:30Z date_updated: 2026-04-15T07:37:25Z file_id: '21656' file_name: 2026_Baig_Mirza_Ahad_Thesis.pdf file_size: 1942037 relation: main_file file_date_updated: 2026-04-15T07:37:25Z has_accepted_license: '1' language: - iso: eng month: '03' oa: 1 oa_version: Published Version publication_identifier: isbn: - 978-3-99078-078-7 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '21134' relation: part_of_dissertation status: public - id: '20587' relation: part_of_dissertation status: public status: public supervisor: - first_name: Krzysztof Z full_name: Pietrzak, Krzysztof Z id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87 last_name: Pietrzak orcid: 0000-0002-9139-1654 title: On secure chain selection rules from physical resources in a permissionless setting tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2026' ... --- OA_place: publisher _id: '20991' abstract: - lang: eng text: "Rapid local adaptation to new environments is critical for species persistence, especially in introduced populations. The evolutionary success of these populations is fundamentally dictated by the organization of genetic variation—the genomic architecture—in the face of severe demographic constraints, such as the founder effects and genetic bottlenecks that frequently accompany colonization. A central question in evolutionary biology is whether rapid adaptation relies on major-effect loci, such as chromosomal inversions, or on many small-effect loci dispersed across the genome. Furthermore, the genomic architecture strongly influences the extent to which evolutionary outcomes are predictable. Using introduced populations of the marine snail, Littorina saxatilis, as a model, this thesis investigates how genetic variation and genomic structure drive adaptation following introduction. We employed a population genomics approach on experimentally and accidentally introduced populations to dissect the specific genomic features that underpin divergence in newly colonized environments.\r\n\r\nIn Chapter 2, we tested the predictability of local adaptation through an uncommon 30-year transplant experiment in nature. By distinguishing allele and chromosomal inversion frequency changes from neutral expectations, we found that evolutionary change was highly predictable at the macro-scale (phenotypes and chromosomal inversions), but less robust at the level of individual collinear loci. This result demonstrates that evolution can be predictable when a population possesses sufficient standing genetic variation (SGV), with chromosomal inversions acting as key integrated units that facilitate a rapid response to selection. Building on this, Chapter 3 applied whole-genome sequencing to three accidentally introduced populations (Venice, San Francisco, and Redwood City) to investigate their likely source and genomic patterns of divergence. We identified genomic regions of remarkable divergence potentially associated with local adaptation, and likely fuelled by SGV, while explicitly acknowledging the difficulty in disentangling selection signals from the genome-wide effects of demographic processes. Furthermore, we found that the divergence patterns relied extensively on the collinear genome in these introduced populations, and less clearly on the chromosomal inversions. This observation contrasts with local adaptation observed in the experimental system that relied on both collinear loci and highly selected chromosomal inversions, highlighting how demographic history and genomic architecture influence the detectable signature of local adaptation.\r\n\r\nA major limitation to conducting large-scale comparative evolutionary studies is the lack of data standardization, which prevents the integration of community knowledge and high-resolution environmental and genetic data. Chapter 4 addresses this by developing a community database for the Littorina system. This platform implements standardized protocols for the integration of diverse phenotypic and environmental data from multiple Littorina species. Likewise, the platform also centralizes the availability of associated genomic data through links to external repositories. This database represents a crucial tool to test complex, large-scale evolutionary hypotheses.\r\n\r\nCollectively, this thesis strongly reinforces the fundamental importance of SGV as the raw material for successful local adaptation, a conclusion supported by evidence in both experimental and accidental introductions. Furthermore, this work highlights the critical role of the genomic architecture—specifically chromosomal inversions—in driving the predictability and effectiveness of adaptive responses. Our findings underscore how the interplay between SGV and genomic architecture dictates the trajectory and detectability of evolution in colonizing populations, while simultaneously providing a necessary tool to advance comparative evolutionary genomics in emerging model organisms." acknowledgement: "I acknowledge the funding agencies 1Norwegian Research Council RCN project 315287.\r\n2The FIASCO project \"Illuminating range shifts through evolutionary FIASCO: contrasting\r\nFaIling And Successful ColOnizations in replicated wild populations\", funded by the\r\nEuropean Union - Next Generation EU (Piano Nazionale di Ripresa e Resilienza - MUR\r\ncode: P202229JBC, CUP: C53D23007100001). 3Ecotypic formation in Littorina saxatilis\r\nin the Western Atlantic and comparisons across the North Atlantic. University of\r\nGothenburg Research Travel Grant, Tjarno Marine Laboratory, Sweden. $3023 (2018).\r\n4JIN project (Young Researchers, Spanish Ministry of Science, RTI2018-101274-J-I00)" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Diego Fernando full_name: Garcia Castillo, Diego Fernando id: ae681a14-dc74-11ea-a0a7-c6ef18161701 last_name: Garcia Castillo citation: ama: Garcia Castillo DF. The genomic architecture of local adaptation in introduced populations. 2026. doi:10.15479/AT-ISTA-20991 apa: Garcia Castillo, D. F. (2026). The genomic architecture of local adaptation in introduced populations. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20991 chicago: Garcia Castillo, Diego Fernando. “The Genomic Architecture of Local Adaptation in Introduced Populations.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-20991. ieee: D. F. Garcia Castillo, “The genomic architecture of local adaptation in introduced populations,” Institute of Science and Technology Austria, 2026. ista: Garcia Castillo DF. 2026. The genomic architecture of local adaptation in introduced populations. Institute of Science and Technology Austria. mla: Garcia Castillo, Diego Fernando. The Genomic Architecture of Local Adaptation in Introduced Populations. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-20991. short: D.F. Garcia Castillo, The Genomic Architecture of Local Adaptation in Introduced Populations, Institute of Science and Technology Austria, 2026. corr_author: '1' date_created: 2026-01-16T09:47:59Z date_published: 2026-01-16T00:00:00Z date_updated: 2026-04-16T12:20:37Z day: '16' ddc: - '576' degree_awarded: PhD department: - _id: GradSch - _id: NiBa doi: 10.15479/AT-ISTA-20991 file: - access_level: closed checksum: 841f1bc073d667125729b2a017f8c37a content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: dgarciac date_created: 2026-01-16T12:25:13Z date_updated: 2026-01-16T12:25:13Z file_id: '20996' file_name: 2026_Garcia_Diego_Thesis.docx file_size: 22456421 relation: source_file - access_level: open_access checksum: a1f33d4f183ce7072eee42a6ccf5340b content_type: application/pdf creator: dgarciac date_created: 2026-01-16T12:25:13Z date_updated: 2026-01-16T12:25:13Z file_id: '20997' file_name: 2026_Garcia_Diego_Thesis.pdf file_size: 9556719 relation: main_file success: 1 - access_level: closed checksum: 98a80691067174c30fe53f38ce7344e6 content_type: application/x-compressed creator: dgarciac date_created: 2026-01-16T13:08:14Z date_updated: 2026-01-16T13:08:14Z description: Source code of the PostgreSQL database, front-end and back-end of the LittorinaDB web application developed as a product of the 4th chapter of the thesis. file_id: '20998' file_name: 2026_DiegoGarcia_LittorinaDB Source Code and Protocols.rar file_size: 54491433 relation: supplementary_material - access_level: open_access checksum: 99a3cab2fa36666b9a92eefc27d586da content_type: application/x-compressed creator: dgarciac date_created: 2026-01-16T13:08:14Z date_updated: 2026-01-16T13:08:14Z file_id: '20999' file_name: 2026_DiegoGarcia_Thesis-Supplementary_Material.rar file_size: 7982811 relation: supplementary_material - access_level: open_access checksum: 255fdf56b2932c46bf27c63aa6106a4f content_type: text/plain creator: dgarciac date_created: 2026-01-16T13:08:59Z date_updated: 2026-01-16T13:08:59Z file_id: '21000' file_name: README.txt file_size: 732 relation: supplementary_material file_date_updated: 2026-01-16T13:08:59Z has_accepted_license: '1' language: - iso: eng month: '01' oa: 1 oa_version: Published Version page: '199' publication_identifier: isbn: - 978-3-99078-077-0 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '18498' relation: research_data status: public - id: '18491' relation: part_of_dissertation status: public status: public supervisor: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 - first_name: Anja M full_name: Westram, Anja M id: 3C147470-F248-11E8-B48F-1D18A9856A87 last_name: Westram orcid: 0000-0003-1050-4969 title: The genomic architecture of local adaptation in introduced populations tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2026' ... --- OA_place: publisher _id: '19684' abstract: - lang: eng text: "The overarching goal of this thesis is to break down the complexity of turbulent flows in terms of enumerable, coherent structures and patterns. In a five-paper series, we adopt a variety of perspectives and techniques to relate the properties of systems of increasing complexity to their underlying coherent structures. \r\n\r\nInitially, we take a dynamical systems point of view, seeing turbulent flow as a chaotic trajectory bouncing between exact unstable solutions of the underlying equations of motion. Using persistent homology, the main tool of topological data analysis capturing the persistence across scales of topological features in a point cloud, we introduce a method that quantifies visits of turbulent trajectories to unstable time-periodic solutions, also called periodic orbits. We demonstrate this method first in the Rössler and Kuramoto–Sivashinsky systems. Using this method in 3D Kolmogorov flow, we extract a Markov chain from turbulent data, where each node corresponds to the neighbourhood of a periodic orbit. The invariant distribution of this Markov chain reproduces expectation values on turbulent data when it is used to weight averages on the respective periodic orbits.\r\n\r\nIn more realistic, wall-bounded settings, such as plane-Couette flow (pcf) driven by the relative motion of the walls, or plane-Poiseuille flow (ppf) driven by a pressure gradient, finding exact solutions is difficult. We use dynamic mode decomposition (DMD), a dimensionality reduction method for sequential data, to identify and approximate low-dimensional dynamics without knowing any exact solutions. Most spatially-extended systems are equivariant under translations, and in such cases spatial drifts dominate DMD, hindering its use in the search for and modelling of low-dimensional dynamics. We augment DMD with a symmetry reduction method trained on turbulent data to stop it from seeing translations as a feature, improving its ability to extract dynamical information in translation-equivariant systems. We find segments of turbulent trajectories that linearize well with their symmetry-reduced DMD spectra, akin to dynamics near exact solutions. Searching for harmonics in the spectra gives leads for periodic orbits with spatial drifts, one of which converges to a new solution.\r\n\r\nIn larger domains, turbulence can localize and coexist with surrounding laminar flow. Our preceding approaches are global, taking all of a domain into account at once, and cannot readily treat each localized patch individually. Working first in a minimal oblique domain that can host a single 1D-localized turbulent patch, we find that turbulence in ppf is connected to a stable periodic orbit at a flow velocity much lower than when turbulence is first onset. We show that, well in advance of sustained turbulence, chaos sets in explosively, and for long time horizons, time series are consistent with that of a random process.\r\n\r\nFinally, in much larger domains, we study and compare 2D-localized turbulence that appears as large-scale inclined structures, called stripes, in ppf and pcf. While appearing similar, we find that stripes in these two settings differ significantly in terms of how they sustain themselves, and in higher velocities, how they proliferate." acknowledged_ssus: - _id: ScienComp acknowledgement: "The work in this thesis was supported by a grant from the Simons Foundation (662960, BH).\r\n" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Gökhan full_name: Yalniz, Gökhan id: 66E74FA2-D8BF-11E9-8249-8DE2E5697425 last_name: Yalniz orcid: 0000-0002-8490-9312 citation: ama: 'Yalniz G. Transition to turbulence : Data-, solution-, and pattern-driven approaches. 2025. doi:10.15479/AT-ISTA-19684' apa: 'Yalniz, G. (2025). Transition to turbulence : Data-, solution-, and pattern-driven approaches. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19684' chicago: 'Yalniz, Gökhan. “Transition to Turbulence : Data-, Solution-, and Pattern-Driven Approaches.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19684.' ieee: 'G. Yalniz, “Transition to turbulence : Data-, solution-, and pattern-driven approaches,” Institute of Science and Technology Austria, 2025.' ista: 'Yalniz G. 2025. Transition to turbulence : Data-, solution-, and pattern-driven approaches. Institute of Science and Technology Austria.' mla: 'Yalniz, Gökhan. Transition to Turbulence : Data-, Solution-, and Pattern-Driven Approaches. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19684.' short: 'G. Yalniz, Transition to Turbulence : Data-, Solution-, and Pattern-Driven Approaches, Institute of Science and Technology Austria, 2025.' corr_author: '1' date_created: 2025-05-12T15:12:28Z date_published: 2025-05-13T00:00:00Z date_updated: 2026-04-07T11:47:06Z day: '13' ddc: - '514' - '519' - '532' - '004' degree_awarded: PhD department: - _id: GradSch - _id: BjHo doi: 10.15479/AT-ISTA-19684 file: - access_level: open_access checksum: 0e452642b79f13633f1595bde71a67e3 content_type: application/pdf creator: gyalniz date_created: 2025-05-12T15:13:28Z date_updated: 2025-05-12T15:13:28Z file_id: '19685' file_name: Gökhan Yalnız - PhD thesis.pdf file_size: 20058169 relation: main_file success: 1 - access_level: open_access checksum: 921099d76adab2df784ce12ce41cfb22 content_type: video/mp4 creator: gyalniz date_created: 2025-05-12T15:15:59Z date_updated: 2025-05-12T15:43:28Z description: '3D visualizations of the turbulent flow (left) and the periodic orbits (middle) that are being shadowed along with the local state space projections (right) onto the principal components of the respective periodic orbit. Shown here are the isosurfaces of velocity (red/blue: ±95% of the instantaneous maximum) and vorticity (purple/green: ±65% of the instantaneous maximum) in the x-direction. Markers along the projections are in sync with the 3D visualizations. The movie corresponds to the initial time interval (up to t = 100) of figure 2.2 (a,b); periodic orbits and the state space projections are shown only through the shadowing events indicated in figure 2.2 (b).' file_id: '19686' file_name: Movie 2A.1.mp4 file_size: 37763743 relation: supplementary_material title: Chapter 2 - Movie 2A.1 - access_level: open_access checksum: 0ae5ac7d9896003c0c4207dd746808dc content_type: video/mp4 creator: gyalniz date_created: 2025-05-12T15:16:09Z date_updated: 2025-05-12T15:43:28Z description: 'Turbulent flow (left) in HKW domain and its symmetry reduction (right). Shown here are the isosurfaces of streamwise velocity (red/blue: u = 0.5 max/min u) and streamwise vorticity (green/purple: ω_x = 0.5 max/min ω_x).' file_id: '19687' file_name: Movie 3A.1.mp4 file_size: 3902655 relation: supplementary_material title: Chapter 3 - Movie 3A.1 - access_level: open_access checksum: ef8d270e066c1a9c3cb5ae46acf945e6 content_type: video/mp4 creator: gyalniz date_created: 2025-05-12T15:16:21Z date_updated: 2025-05-12T15:43:28Z description: 'Turbulent flow (left) in P2K domain and its symmetry reduction (right). Shown here are the isosurfaces of streamwise velocity (red/blue: u = 0.5 max/min u) and streamwise vorticity (green/purple: ω_x = 0.5 max/min ω_x).' file_id: '19688' file_name: Movie 3A.2.mp4 file_size: 7043169 relation: supplementary_material title: Chapter 3 - Movie 3A.2 - access_level: open_access checksum: 7ed871f428100d6827ac9b0e8ca8e985 content_type: video/mp4 creator: gyalniz date_created: 2025-05-12T15:16:36Z date_updated: 2025-05-12T15:43:28Z description: 'Relative periodic orbit RPO_79.4 (left) of the plane-Couette flow (HKW domain) and its symmetry reduction (right). Shown here are the isosurfaces of streamwise velocity (red/blue: u = 0.5 max/min u) and streamwise vorticity (green/purple: ω_x = 0.5 max/min ω_x).' file_id: '19689' file_name: Movie 3A.3.mp4 file_size: 7748659 relation: supplementary_material title: Chapter 3 - Movie 3A.3 - access_level: open_access checksum: dd5a252e1da00c8f303588e22e2baeef content_type: video/mp4 creator: gyalniz date_created: 2025-05-12T15:16:50Z date_updated: 2025-05-12T15:43:28Z description: 'Symmetry-reduced flow (left), its SRDMD approximation (middle), and state space projection (right) showing the spiral-out episode in P2K domain (figure 3.6 (b) and figure 3.8 (b)). Shown here are the isosurfaces of streamwise velocity (red/blue: u = 0.5 max/min u) and streamwise vorticity (green/purple: ω_x = 0.5 max/min ω_x).' file_id: '19690' file_name: Movie 3A.4.mp4 file_size: 5873052 relation: supplementary_material title: Chapter 3 - Movie 3A.4 - access_level: open_access checksum: 5ac58b86810698db28cbfc28f351ff70 content_type: video/mp4 creator: gyalniz date_created: 2025-05-12T15:17:11Z date_updated: 2025-05-12T15:43:28Z description: Movie demonstrating the quasi-steady Reynolds number descent from turbulence to a periodic orbit. file_id: '19691' file_name: Movie 4A.1.mp4 file_size: 9209327 relation: supplementary_material title: Chapter 4 - Movie 4A.1 - access_level: open_access checksum: ac877f1e1ef39439911bf37cb1793b8e content_type: video/mp4 creator: gyalniz date_created: 2025-05-12T15:17:43Z date_updated: 2025-05-12T15:43:28Z description: Streamwise velocity fluctuations (from laminar) of plane-Couette flow (Re^C =335) at the y = 0 wall-normal plane in coordinates stationary with respect to the bulk velocity. Here, x is the streamwise direction (the wall at y = 1 moves to the right) and z is the spanwise direction. Time is in advectime time units. Shown is the full (L_x = L_z = 400) domain. file_id: '19692' file_name: Movie 5A.1.mp4 file_size: 5893993 relation: supplementary_material title: Chapter 5 - Movie 5A.1 - access_level: open_access checksum: fd17eabb70129ceaa414e40924d1d2fe content_type: video/mp4 creator: gyalniz date_created: 2025-05-12T15:17:49Z date_updated: 2025-05-12T15:43:28Z description: Streamwise velocity fluctuations (from laminar) of plane-Poiseuille flow (Re^P =660) at the y = 0.5 wall-normal plane in coordinates stationary with respect to the bulk velocity. Here, x is the streamwise direction (the mean negative pressure gradient is to the right) and z is the spanwise direction. Time is in advectime time units. Shown is the full (L_x = L_z = 400) domain. file_id: '19693' file_name: Movie 5A.2.mp4 file_size: 3990352 relation: supplementary_material title: Chapter 5 - Movie 5A.2 - access_level: open_access checksum: 32f904497ab0bbee38f0788d96b91454 content_type: video/mp4 creator: gyalniz date_created: 2025-05-12T15:17:58Z date_updated: 2025-05-12T15:43:28Z description: Streamwise velocity fluctuations (from laminar) of plane-Poiseuille flow (Re^P=660) at the y = 0.5 wall-normal plane in coordinates stationary with respect to the average velocity of the downstream tip of the stripe. Here, x is the streamwise direction (the mean negative pressure gradient is to the right) and z is the spanwise direction. Time is in advectime time units. Shown is a zoom-in of the full (L_x = L_z) domain. file_id: '19694' file_name: Movie 5A.3.mp4 file_size: 5171009 relation: supplementary_material title: Chapter 5 - Movie 5A.3 - access_level: closed checksum: f313261b9bb12dfb943fead8318954c6 content_type: application/x-zip-compressed creator: gyalniz date_created: 2025-05-12T15:27:10Z date_updated: 2025-05-12T15:43:28Z file_id: '19695' file_name: Gökhan Yalnız - PhD thesis.zip file_size: 18991996 relation: source_file file_date_updated: 2025-05-12T15:43:28Z has_accepted_license: '1' language: - iso: eng month: '05' oa: 1 oa_version: Published Version page: '155' project: - _id: 238598C6-32DE-11EA-91FC-C7463DDC885E grant_number: '662960' name: Revisiting the Turbulence Problem Using Statistical Mechanics publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '7563' relation: part_of_dissertation status: public - id: '9558' relation: part_of_dissertation status: public - id: '12105' relation: part_of_dissertation status: public - id: '13274' relation: part_of_dissertation status: public - id: '14466' relation: part_of_dissertation status: public status: public supervisor: - first_name: Björn full_name: Hof, Björn id: 3A374330-F248-11E8-B48F-1D18A9856A87 last_name: Hof orcid: 0000-0003-2057-2754 title: 'Transition to turbulence : Data-, solution-, and pattern-driven approaches' type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '18979' abstract: - lang: eng text: "Topological Data Analysis (TDA) is a discipline utilizing the mathematical field of topology to study data, most prominently collections of point sets. This thesis summarizes three projects related to computations in TDA.\r\n\r\nThe first one establishes a variant of TDA for chromatic point sets, where each point is given a color. For example, we are given positions of cells within a tumor microenvironment, and color the cancerous cells red, and the immune cells blue.\r\n\r\nThe aim is then to give a quantitative description of how the two or more sets of points spatially interact. Building on image, kernel and cokernel variants of persistent homology, we suggest six-packs of persistent diagrams as such a descriptor.\r\n\r\nWe describe a construction of a chromatic alpha complex, which enables efficient computation of several variants of the six-packs. We give topological descriptions of natural subcomplexes of the chromatic alpha complex, and show that the radii of the simplices form a discrete Morse function. Finally, we provide an implementation of the presented chromatic TDA pipeline.\r\n\r\nThe second part aims to translate a powerful tool of sheaf theory to elementary terms using labeled matrices. The goal is to enable their use in computational settings. We show that derived categories of sheaves over finite posets have, up to isomorphism, unique objects---minimal injective resolutions---and give a concrete algorithm to compute them. We further describe simple algorithms to compute derived pushforwards and pullbacks for monotonic maps, and their proper variants for inclusions, and demonstrate their tractability by providing an implementation. Finally, we suggest a discrete definition of microsupport and show desirable properties inspired by discrete Morse theory.\r\n\r\nIn the last part, we present a collection of observations about collapses. We give a characterization of collapsibility in terms of unitriangular submatrices of the boundary matrix, a cotree-tree decomposition, and the optimal solution to a variant of the Procrustes problem. We establish relation between dual collapses and relative Morse theory and pose several open questions. Finally, focusing on complexes embedded in the three-dimensional Euclidean space, we describe a relation between the collapsibility and the triviality of a polygonal knot." acknowledgement: "The research presented in this thesis was funded with the Wittgenstein Prize,\r\nAustrian Science Fund (FWF), grant no. Z 342-N31, and from the DFG Collaborative Research\r\nCenter TRR 109, ‘Discretization in Geometry and Dynamics’, Austrian Science Fund (FWF),\r\ngrant no. I 02979-N35.\r\n" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Ondrej full_name: Draganov, Ondrej id: 2B23F01E-F248-11E8-B48F-1D18A9856A87 last_name: Draganov orcid: 0000-0003-0464-3823 citation: ama: Draganov O. Structures and computations in topological data analysis. 2025. doi:10.15479/at:ista:18979 apa: Draganov, O. (2025). Structures and computations in topological data analysis. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:18979 chicago: Draganov, Ondrej. “Structures and Computations in Topological Data Analysis.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/at:ista:18979. ieee: O. Draganov, “Structures and computations in topological data analysis,” Institute of Science and Technology Austria, 2025. ista: Draganov O. 2025. Structures and computations in topological data analysis. Institute of Science and Technology Austria. mla: Draganov, Ondrej. Structures and Computations in Topological Data Analysis. Institute of Science and Technology Austria, 2025, doi:10.15479/at:ista:18979. short: O. Draganov, Structures and Computations in Topological Data Analysis, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-01-31T17:04:40Z date_published: 2025-02-03T00:00:00Z date_updated: 2026-04-07T11:47:30Z day: '03' ddc: - '514' - '004' degree_awarded: PhD department: - _id: GradSch - _id: HeEd doi: 10.15479/at:ista:18979 file: - access_level: closed checksum: af6567e5d35e5eb330b8925ae37f1998 content_type: application/zip creator: odragano date_created: 2025-01-31T16:58:30Z date_updated: 2025-01-31T16:58:30Z file_id: '18983' file_name: Thesis.zip file_size: 11899491 relation: source_file - access_level: open_access checksum: c3fef68e35b9dc2020b2ca6006da6343 content_type: application/pdf creator: odragano date_created: 2025-02-04T16:22:07Z date_updated: 2025-02-04T16:22:07Z file_id: '19000' file_name: Thesis.pdf file_size: 8857514 relation: main_file file_date_updated: 2025-02-04T16:22:07Z has_accepted_license: '1' keyword: - topological data analysis - chromatic point set - alpha complex - persistent homology - six pack - sheaf - microlocal discrete Morse - injective resolution - collapse - knot - discrete Morse theory language: - iso: eng month: '02' oa: 1 oa_version: Published Version page: '140' project: - _id: 2561EBF4-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I02979-N35 name: Persistence and stability of geometric complexes - _id: 268116B8-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: Z00342 name: Mathematics, Computer Science publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '15091' relation: part_of_dissertation status: public - id: '18981' relation: part_of_dissertation status: public status: public supervisor: - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 title: Structures and computations in topological data analysis tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20206' abstract: - lang: eng text: "The internal structure of biomolecules and their organization in higher-order arrangements are key factors governing the working principles of biological systems. Bioimaging has successfully revealed arrangements across relevant spatial scales. For example, cryo-electron tomography has become widely used for analyzing biomolecular structures in situ due to its comprehensive structural visualization of near-natively preserved samples, and its capability of sub-nm resolution via averaging. However, the identification of molecules within crowded cellular environments is often hindered by low contrast. Fluorescence microscopy, on the other hand, routinely visualizes specifically labeled targets at single-molecule contrast against essentially zero background. Moreover, it provides comparatively high throughput and is amenable to multiplexing. Due to this complementarity, combining datasets from both modalities acquired on the same region via correlative light and electron microscopy can reveal novel types of information. \r\nThe spatial scale at which information can be extracted depends on imaging resolution and correlation accuracy. Since diffraction of light limits the resolution of conventional fluorescence microscopy to few hundreds of nanometers, reaching the full potential of correlative imaging requires super-resolution approaches. Performing imaging at cryogenic temperature preserves structures in a near-native state and minimizes distortions between the fluorescence and the electron microscopy datasets. Implementations of this concept have achieved correlation on the scale of cellular organelles or bacterial domains.\r\nWe have worked towards pushing correlative imaging to the single-molecule scale by improving cryo-super-resolution microscopy, and devising a refined image correlation workflow. As part of this project, I constructed a microscopy setup and adopted it for super-resolution fluorescence microscopy at room temperature and cryogenic conditions. I explored different cryo-stages and acquisition strategies. Specifically, I developed a new scheme for correcting sample drift, thus increasing mechanical stability during microscopy acquisitions.\r\n" acknowledged_ssus: - _id: M-Shop - _id: EM-Fac - _id: Bio acknowledgement: "The project was supported by CZI grant DAF2021-234754 and grant\r\nDOI: https://doi.org/10.37921/812628ebpcwg from the Chan Zuckerberg Initiative DAF, an\r\nadvised fund of Silicon Valley Community Foundation (funder\r\nDOI: https://doi.org/10.13039/100014989), as well as internal grants from ISTA’s Equipment\r\nInvestment Committee and Interdisciplinary Project Committee. " alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Jakob full_name: Vorlaufer, Jakob id: 937696FA-C996-11E9-8C7C-CF13E6697425 last_name: Vorlaufer orcid: 0009-0000-7590-3501 citation: ama: Vorlaufer J. Construction of a cryo-super-resolution microscope to guide in situ structure analysis. 2025. doi:10.15479/AT-ISTA-20206 apa: Vorlaufer, J. (2025). Construction of a cryo-super-resolution microscope to guide in situ structure analysis. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20206 chicago: Vorlaufer, Jakob. “Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20206. ieee: J. Vorlaufer, “Construction of a cryo-super-resolution microscope to guide in situ structure analysis,” Institute of Science and Technology Austria, 2025. ista: Vorlaufer J. 2025. Construction of a cryo-super-resolution microscope to guide in situ structure analysis. Institute of Science and Technology Austria. mla: Vorlaufer, Jakob. Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20206. short: J. Vorlaufer, Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-08-22T08:12:55Z date_published: 2025-08-25T00:00:00Z date_updated: 2026-04-07T11:48:07Z day: '25' ddc: - '621' - '535' degree_awarded: PhD department: - _id: GradSch - _id: JoDa doi: 10.15479/AT-ISTA-20206 file: - access_level: closed checksum: 191db3367c19c9b32b65f4bc3a7c19de content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: jvorlauf date_created: 2025-08-25T13:49:55Z date_updated: 2025-08-25T13:49:55Z file_id: '20228' file_name: 2025_Vorlaufer_Jakob_Thesis.docx file_size: 39735535 relation: source_file - access_level: open_access checksum: 104400e6036921569610230c1d4899dc content_type: application/pdf creator: jvorlauf date_created: 2025-08-25T13:49:56Z date_updated: 2025-08-25T13:49:56Z file_id: '20229' file_name: 2025_Vorlaufer_Jakob_Thesis.pdf file_size: 10947446 relation: main_file success: 1 file_date_updated: 2025-08-25T13:49:56Z has_accepted_license: '1' language: - iso: eng month: '08' oa: 1 oa_version: Published Version page: '107' project: - _id: 62909c6f-2b32-11ec-9570-e1476aab5308 grant_number: CZI01 name: CryoMinflux-guided in-situ molecular census and structure determination publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '19795' relation: part_of_dissertation status: public status: public supervisor: - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 title: Construction of a cryo-super-resolution microscope to guide in situ structure analysis tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_embargo: '12' OA_place: publisher _id: '19722' acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: Special thanks to the Plant Facility. alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Syamala full_name: Inumella, Syamala id: F8660870-D756-11E9-98C5-34DFE5697425 last_name: Inumella orcid: 0009-0002-5890-120X citation: ama: Inumella S. Molecular mechanisms of microtubule reorganization in elongating root epidermal cells. 2025. doi:10.15479/AT-ISTA-19722 apa: Inumella, S. (2025). Molecular mechanisms of microtubule reorganization in elongating root epidermal cells. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19722 chicago: Inumella, Syamala. “Molecular Mechanisms of Microtubule Reorganization in Elongating Root Epidermal Cells.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19722. ieee: S. Inumella, “Molecular mechanisms of microtubule reorganization in elongating root epidermal cells,” Institute of Science and Technology Austria, 2025. ista: Inumella S. 2025. Molecular mechanisms of microtubule reorganization in elongating root epidermal cells. Institute of Science and Technology Austria. mla: Inumella, Syamala. Molecular Mechanisms of Microtubule Reorganization in Elongating Root Epidermal Cells. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19722. short: S. Inumella, Molecular Mechanisms of Microtubule Reorganization in Elongating Root Epidermal Cells, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-05-23T15:21:29Z date_published: 2025-05-23T00:00:00Z date_updated: 2026-04-07T11:47:52Z day: '23' ddc: - '580' degree_awarded: PhD department: - _id: GradSch - _id: EvBe doi: 10.15479/AT-ISTA-19722 file: - access_level: closed checksum: 847ec70b2e40f50e0ddc7b8da201d52c content_type: application/pdf creator: sinumell date_created: 2025-05-28T11:59:11Z date_updated: 2025-05-28T11:59:11Z embargo: 2026-05-23 embargo_to: open_access file_id: '19757' file_name: Final Thesis_Syamala Inumella.pdf file_size: 8292363 relation: main_file - access_level: closed checksum: 17cdffdae13a5f65bdad9c84e9e0e3bd content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: sinumell date_created: 2025-05-28T11:59:11Z date_updated: 2025-05-28T11:59:11Z file_id: '19758' file_name: Final Thesis_Syamala Inumella.docx file_size: 7145703 relation: source_file file_date_updated: 2025-05-28T11:59:11Z has_accepted_license: '1' language: - iso: eng month: '05' oa_version: Published Version page: '113' publication_identifier: isbn: - 978-3-99078-059-6 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria status: public supervisor: - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 title: Molecular mechanisms of microtubule reorganization in elongating root epidermal cells type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20138' abstract: - lang: eng text: "The evolution shapes the world around us.\r\nNot only in biology, where the fittest individuals spread their genes but also in physics and social dynamics, the evolutionary forces determine the development of a state of matter or public opinions.\r\nMany models describe these dynamics.\r\nThis thesis examines the role of the structure in the models of selection.\r\nThe population structure is represented as a graph or a network, and each vertex is occupied by one individual.\r\nEvery individual has a type and fitness that represents the reproductive potential and depends on the type, occupied vertex, and the arrangement of the neighbors.\r\nThe evolution is modeled in discrete steps; in one step, one individual is replaced by a neighbor selected randomly with the influence of fitness.\r\n\r\n\r\n\r\nThe role of the networks is widely examined in the literature.\r\nThe structures that promote the spread of the desired type compared to the structureless case are called amplifiers.\r\nThe existence of amplifiers in various settings is an intensively studied topic, and in some settings, the amplifiers have been identified.\r\nMoreover, there are other important questions about the number of steps until one type spreads over the whole network (fixation time), the computational complexity, and the questions about the robustness of these processes.\r\n\r\n\r\nThis thesis explores the role of structure in evolution from many perspectives.\r\nFirst, it introduces different models and various choices that can be made in the models of evolution.\r\nIt highlights the role of the structure in the real world and how this is reflected in these models.\r\nThen, it describes the previous results and open problems.\r\nSecond, the thesis describes an amplifier for two variants of the Moran process: one with a constant birth rate and the other with a constant death rate.\r\nThis is an important contribution to the robustness of the amplification.\r\nThird, the thesis determines the complexity of spatial games.\r\nThese are processes where the fitness comes from a game, and the strength of selection is high.\r\nIt shows that determining the fate of cooperation in these games is a PSPACE-complete problem.\r\nFourth, the thesis describes the amplifier of cooperation for spatial games.\r\nThis is the first amplifier in this setting.\r\nFifth, the thesis examines the coexistence in the Moran process with environmental heterogeneity.\r\nIn this setting, the fitness depends not only on the type of the individual but also on the occupied vertex.\r\nThe chapter determines the relationship between the interactions of vertices of different types and the coexistence time.\r\nSixth, the thesis examines the social balance on networks and proposes a stochastic dynamic partially aware of the state of the graph, which reaches a balanced position quickly.\r\nFinally, the thesis presents conclusions and outlines the directions for future work.\r\n\r\n\r\n" acknowledgement: "This work was supported by the European Research Council CoG 863818 (ForMSMArt) and Austrian Science Fund 10.55776/COE12.\r\n" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Jakub full_name: Svoboda, Jakub id: 130759D2-D7DD-11E9-87D2-DE0DE6697425 last_name: Svoboda orcid: 0000-0002-1419-3267 citation: ama: Svoboda J. Structural properties of games on graphs. 2025. doi:10.15479/AT-ISTA-20138 apa: Svoboda, J. (2025). Structural properties of games on graphs. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20138 chicago: Svoboda, Jakub. “Structural Properties of Games on Graphs.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20138. ieee: J. Svoboda, “Structural properties of games on graphs,” Institute of Science and Technology Austria, 2025. ista: Svoboda J. 2025. Structural properties of games on graphs. Institute of Science and Technology Austria. mla: Svoboda, Jakub. Structural Properties of Games on Graphs. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20138. short: J. Svoboda, Structural Properties of Games on Graphs, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-08-05T14:33:59Z date_published: 2025-08-05T00:00:00Z date_updated: 2026-04-07T11:49:12Z day: '05' ddc: - '000' - '519' degree_awarded: PhD department: - _id: GradSch - _id: KrCh doi: 10.15479/AT-ISTA-20138 ec_funded: 1 file: - access_level: open_access checksum: c6c4df9777f4537940de7ab392ad57e2 content_type: application/pdf creator: jsvoboda date_created: 2025-08-14T09:54:43Z date_updated: 2025-08-14T09:54:43Z file_id: '20177' file_name: 2025_Svoboda_Jakub_Thesis.pdf file_size: 5927291 relation: main_file success: 1 - access_level: closed checksum: 485e9f9822821bc03666d245d80aaa08 content_type: application/zip creator: jsvoboda date_created: 2025-08-14T09:55:20Z date_updated: 2025-08-21T11:48:39Z file_id: '20178' file_name: 2025_Svoboda_Jakub_Thesis.zip file_size: 6731815 relation: source_file file_date_updated: 2025-08-21T11:48:39Z has_accepted_license: '1' language: - iso: eng month: '08' oa: 1 oa_version: Published Version page: '167' project: - _id: 0599E47C-7A3F-11EA-A408-12923DDC885E call_identifier: H2020 grant_number: '863818' name: 'Formal Methods for Stochastic Models: Algorithms and Applications' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '12787' relation: part_of_dissertation status: public - id: '12101' relation: part_of_dissertation status: public - id: '12257' relation: part_of_dissertation status: public - id: '15297' relation: part_of_dissertation status: public - id: '18703' relation: part_of_dissertation status: public status: public supervisor: - first_name: Krishnendu full_name: Chatterjee, Krishnendu id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X title: Structural properties of games on graphs tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20117' acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: PreCl acknowledgement: "I would also like to acknowledge the invaluable assistance provided by the Plant\r\nFacility, Imaging & Optics Facility, and the Lab Support Facility. The technical support and\r\nresources offered by these facilities were indispensable to the successful completion of my\r\nexperiments." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Yiqun full_name: Wang, Yiqun id: 82F537F2-B517-11E9-84D7-6433E6697425 last_name: Wang citation: ama: Wang Y. The role of dynamin related protein 2A in cytokinin regulated plant growth and development. 2025. doi:10.15479/AT-ISTA-20117 apa: Wang, Y. (2025). The role of dynamin related protein 2A in cytokinin regulated plant growth and development. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20117 chicago: Wang, Yiqun. “The Role of Dynamin Related Protein 2A in Cytokinin Regulated Plant Growth and Development.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20117. ieee: Y. Wang, “The role of dynamin related protein 2A in cytokinin regulated plant growth and development,” Institute of Science and Technology Austria, 2025. ista: Wang Y. 2025. The role of dynamin related protein 2A in cytokinin regulated plant growth and development. Institute of Science and Technology Austria. mla: Wang, Yiqun. The Role of Dynamin Related Protein 2A in Cytokinin Regulated Plant Growth and Development. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20117. short: Y. Wang, The Role of Dynamin Related Protein 2A in Cytokinin Regulated Plant Growth and Development, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-08-04T15:24:21Z date_published: 2025-08-04T00:00:00Z date_updated: 2026-04-07T11:49:34Z day: '04' ddc: - '580' degree_awarded: PhD department: - _id: GradSch - _id: EvBe doi: 10.15479/AT-ISTA-20117 file: - access_level: closed checksum: 36b87c17d12c7bf5955d6d812acb8d77 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: yiqwang date_created: 2025-08-22T08:22:10Z date_updated: 2025-08-22T08:53:46Z file_id: '20209' file_name: 2025_Wang_Yiqun_Thesis.docx file_size: 25798848 relation: source_file - access_level: closed checksum: 8d7a2383f66377da675d379ec30ea0fe content_type: application/pdf creator: yiqwang date_created: 2025-08-22T10:32:30Z date_updated: 2025-09-03T09:36:52Z embargo: 2026-09-03 embargo_to: open_access file_id: '20211' file_name: 2025_Wang_Yiqun_Thesis.pdf file_size: 12628313 relation: main_file file_date_updated: 2025-09-03T09:36:52Z has_accepted_license: '1' language: - iso: eng month: '08' oa_version: Published Version page: '108' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '18063' relation: part_of_dissertation status: public status: public supervisor: - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 title: The role of dynamin related protein 2A in cytokinin regulated plant growth and development type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '19759' abstract: - lang: eng text: "Despite generating remarkable results in various computer vision tasks, deep learning comes\r\nwith some surprising shortcomings. For example, tiny perturbations, often imperceptible to\r\nthe human eye, can completely change the predictions of image classifiers. Despite a decade\r\nof research, the field has made limited progress in developing image classifiers that are both\r\naccurate and robust. This thesis aims to address this gap.\r\nAs our first contribution, we aim to simplify the process of training certifiably robust image\r\nclassifiers. We do this by designing a convolutional layer that does not require executing an\r\niterative procedure in every forward pass, but relies on an explicit bound instead. We also\r\npropose a loss function that allows optimizing for a particular margin more precisely.\r\nNext, we provide an overview and comparison of various methods that create robust image\r\nclassifiers by constraining the Lipschitz constant. This is important since generally longer\r\ntraining times and more parameters improve the performance of robust classifiers, making it\r\nchallenging to determine the most practical and effective methods from existing literature.\r\nIn 1-Lipschitz classification, the performance of current methods is still much worse than what\r\nwe expect on the simple tasks we consider. Therefore, we next investigate potential causes of\r\nthis shortcoming. We first consider the role of the activation function. We prove a theoretical\r\nshortcoming of the commonly used activation function, and provide an alternative without it.\r\nHowever this theoretical improvement does barely translate to the empirical performance of\r\nrobust classifiers, suggesting a different bottleneck.\r\nTherefore, in the final chapter, we study how the performance depends on the amount of\r\ntraining data. We prove that in the worst case, we might require far more data to train a\r\nrobust classifier compared to a normal one. We furthermore find that the amount of training\r\ndata is a key determinant of the performance current methods achieve on popular datasets.\r\nAdditionally, we show that linear subspaces exist with tiny data variance, and yet we can\r\nstill train very accurate classifiers after projecting into those subspaces. This shows that on\r\nthe datasets considered, enforcing robustness in classification makes the task strictly more\r\nchallenging.\r\n\r\n-----------------“In reference to IEEE copyrighted material which is used with permission in this thesis, the IEEE does not endorse any of [name of university or educational entity]’s products or services. Internal or personal use of this material is permitted. If interested in reprinting/republishing IEEE copyrighted material for advertising or promotional purposes or for creating new collective works for resale or redistribution, please go to http://www.ieee.org/publications_standards/publications/rights/rights_link.html to learn how to obtain a License from RightsLink. If applicable, University Microfilms and/or ProQuest Library, or the Archives of Canada may supply single copies of the dissertation.”\r\n" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Bernd full_name: Prach, Bernd id: 2D561D42-C427-11E9-89B4-9C1AE6697425 last_name: Prach citation: ama: Prach B. Robust image classification with 1-Lipschitz networks. 2025. doi:10.15479/10.15479/at-ista-19759 apa: Prach, B. (2025). Robust image classification with 1-Lipschitz networks. Institute of Science and Technology Austria. https://doi.org/10.15479/10.15479/at-ista-19759 chicago: Prach, Bernd. “Robust Image Classification with 1-Lipschitz Networks.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/10.15479/at-ista-19759. ieee: B. Prach, “Robust image classification with 1-Lipschitz networks,” Institute of Science and Technology Austria, 2025. ista: Prach B. 2025. Robust image classification with 1-Lipschitz networks. Institute of Science and Technology Austria. mla: Prach, Bernd. Robust Image Classification with 1-Lipschitz Networks. Institute of Science and Technology Austria, 2025, doi:10.15479/10.15479/at-ista-19759. short: B. Prach, Robust Image Classification with 1-Lipschitz Networks, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-05-28T16:20:48Z date_published: 2025-05-30T00:00:00Z date_updated: 2026-04-07T11:49:52Z day: '30' ddc: - '000' degree_awarded: PhD department: - _id: GradSch - _id: ChLa doi: 10.15479/10.15479/at-ista-19759 file: - access_level: open_access checksum: e5108e759014e2a9020c973c778fafc9 content_type: application/pdf creator: bprach date_created: 2025-06-10T18:11:05Z date_updated: 2025-06-10T18:11:05Z file_id: '19829' file_name: ThesisFinal.pdf file_size: 3578077 relation: main_file - access_level: closed checksum: 51bf6c11fb6d8a9f8010b458c600a83f content_type: application/x-zip-compressed creator: bprach date_created: 2025-06-10T18:14:03Z date_updated: 2025-06-10T18:14:03Z file_id: '19830' file_name: ThesisFinal.zip file_size: 74894357 relation: source_file file_date_updated: 2025-06-10T18:14:03Z has_accepted_license: '1' language: - iso: eng month: '05' oa: 1 oa_version: Published Version page: '84' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '15039' relation: part_of_dissertation status: public - id: '18874' relation: part_of_dissertation status: public - id: '17426' relation: part_of_dissertation status: public - id: '11839' relation: part_of_dissertation status: public status: public supervisor: - first_name: Christoph full_name: Lampert, Christoph id: 40C20FD2-F248-11E8-B48F-1D18A9856A87 last_name: Lampert orcid: 0000-0001-8622-7887 title: Robust image classification with 1-Lipschitz networks type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20167' acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: "This work was supported by EMBO (ALTF 302-2019 to Niko Amin-Wetzel), the FWF\r\n(ESPRIT PR1054E140 to Niko Amin-Wetzel), the European Research Council\r\n(Advanced Grant 269058 to Mario de Bono) and Wellcome (209504/A/17/Z\r\nInvestigator Award to Mario de Bono). " alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Hanna full_name: Schön, Hanna id: C8E17EDC-D7AA-11E9-B7B7-45ECE5697425 last_name: Schön citation: ama: Schön H. The ER complex SUTU-7/MACO-1 regulates the fate of mRNAs encoding GPCRs. 2025. doi:10.15479/AT-ISTA-20167 apa: Schön, H. (2025). The ER complex SUTU-7/MACO-1 regulates the fate of mRNAs encoding GPCRs. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20167 chicago: Schön, Hanna. “The ER Complex SUTU-7/MACO-1 Regulates the Fate of MRNAs Encoding GPCRs.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20167. ieee: H. Schön, “The ER complex SUTU-7/MACO-1 regulates the fate of mRNAs encoding GPCRs,” Institute of Science and Technology Austria, 2025. ista: Schön H. 2025. The ER complex SUTU-7/MACO-1 regulates the fate of mRNAs encoding GPCRs. Institute of Science and Technology Austria. mla: Schön, Hanna. The ER Complex SUTU-7/MACO-1 Regulates the Fate of MRNAs Encoding GPCRs. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20167. short: H. Schön, The ER Complex SUTU-7/MACO-1 Regulates the Fate of MRNAs Encoding GPCRs, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-08-13T11:13:13Z date_published: 2025-08-13T00:00:00Z date_updated: 2026-04-07T11:50:26Z day: '13' ddc: - '570' degree_awarded: PhD department: - _id: GradSch - _id: MaDe doi: 10.15479/AT-ISTA-20167 file: - access_level: closed checksum: b40c74404b8d9593802dabf57bfdf10f content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: hschoen date_created: 2025-09-08T14:33:50Z date_updated: 2025-09-09T08:57:04Z file_id: '20311' file_name: 2025_Schoen_Hanna_Thesis.docx file_size: 78812587 relation: source_file - access_level: closed checksum: 16abc3ff66396ce2457fe07ffa8bed90 content_type: application/pdf creator: hschoen date_created: 2025-09-11T14:20:59Z date_updated: 2025-09-18T14:12:29Z embargo: 2026-09-15 embargo_to: open_access file_id: '20347' file_name: 2025_Schoen_Hanna_Thesis.pdf file_size: 9667057 relation: main_file file_date_updated: 2025-09-18T14:12:29Z has_accepted_license: '1' language: - iso: eng month: '08' oa_version: Published Version page: '171' project: - _id: 23870BE8-32DE-11EA-91FC-C7463DDC885E grant_number: 209504/A/17/Z name: Molecular mechanisms of neural circuit function - _id: 23813290-32DE-11EA-91FC-C7463DDC885E grant_number: ALTF 302-2019 name: Control of gene expression at the endoplasmic reticulum publication_identifier: isbn: - 978-3-99078-061-9 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria status: public supervisor: - first_name: Mario full_name: de Bono, Mario id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87 last_name: de Bono orcid: 0000-0001-8347-0443 title: The ER complex SUTU-7/MACO-1 regulates the fate of mRNAs encoding GPCRs tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20362' acknowledged_ssus: - _id: Bio - _id: LifeSc alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: David full_name: Babic, David id: db566d23-f6e0-11ea-865d-e6f270e968e7 last_name: Babic citation: ama: Babic D. Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana. 2025. doi:10.15479/AT-ISTA-20362 apa: Babic, D. (2025). Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20362 chicago: Babic, David. “Mechanisms of Auxin-Mediated Early Embryogenesis in Arabidopsis Thaliana.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20362. ieee: D. Babic, “Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana,” Institute of Science and Technology Austria, 2025. ista: Babic D. 2025. Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana. Institute of Science and Technology Austria. mla: Babic, David. Mechanisms of Auxin-Mediated Early Embryogenesis in Arabidopsis Thaliana. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20362. short: D. Babic, Mechanisms of Auxin-Mediated Early Embryogenesis in Arabidopsis Thaliana, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-09-17T13:28:01Z date_published: 2025-09-18T00:00:00Z date_updated: 2026-04-07T11:52:02Z day: '18' ddc: - '580' degree_awarded: PhD department: - _id: GradSch - _id: JiFr - _id: EvBe doi: 10.15479/AT-ISTA-20362 file: - access_level: closed checksum: 5ecf274281a54a41e0288bc79edf7492 content_type: application/pdf creator: dbabic date_created: 2025-09-24T13:43:14Z date_updated: 2025-09-26T07:29:11Z embargo: 2026-09-25 embargo_to: open_access file_id: '20388' file_name: 2025_David_Babic_Thesis.pdf file_size: 7501548 relation: main_file - access_level: closed checksum: 2703e548390de0a1af7a707137e8ab3b content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: dbabic date_created: 2025-09-24T13:43:14Z date_updated: 2025-09-26T07:29:11Z file_id: '20389' file_name: Thesis_Babic_draft.docx file_size: 23206052 relation: source_file file_date_updated: 2025-09-26T07:29:11Z has_accepted_license: '1' language: - iso: eng month: '09' oa_version: Published Version page: '116' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '20187' relation: part_of_dissertation status: public status: public supervisor: - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 title: Mechanisms of auxin-mediated early embryogenesis in Arabidopsis thaliana tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20415' acknowledged_ssus: - _id: LifeSc - _id: EM-Fac alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Seungho full_name: Lee, Seungho id: BB243B88-D767-11E9-B658-BC13E6697425 last_name: Lee orcid: 0000-0002-6962-8598 citation: ama: Lee S. Nanoparticle-based precursors toward advanced crystalline inorganic solids. 2025. doi:10.15479/AT-ISTA-20415 apa: Lee, S. (2025). Nanoparticle-based precursors toward advanced crystalline inorganic solids. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20415 chicago: Lee, Seungho. “Nanoparticle-Based Precursors toward Advanced Crystalline Inorganic Solids.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20415. ieee: S. Lee, “Nanoparticle-based precursors toward advanced crystalline inorganic solids,” Institute of Science and Technology Austria, 2025. ista: Lee S. 2025. Nanoparticle-based precursors toward advanced crystalline inorganic solids. Institute of Science and Technology Austria. mla: Lee, Seungho. Nanoparticle-Based Precursors toward Advanced Crystalline Inorganic Solids. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20415. short: S. Lee, Nanoparticle-Based Precursors toward Advanced Crystalline Inorganic Solids, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-10-01T09:04:00Z date_published: 2025-10-01T00:00:00Z date_updated: 2026-04-07T11:52:32Z day: '01' ddc: - '540' degree_awarded: PhD department: - _id: GradSch - _id: MaIb doi: 10.15479/AT-ISTA-20415 file: - access_level: closed checksum: fa6d5946feb37b678ee1c6dffb4fa167 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: slee date_created: 2025-10-03T12:29:43Z date_updated: 2025-10-07T08:57:14Z file_id: '20420' file_name: 2025_Lee_Seungho_Thesis.docx file_size: 88706648 relation: source_file - access_level: closed checksum: c5ba6d464113ad0c5812a9d24b539b86 content_type: application/pdf creator: slee date_created: 2025-10-03T12:29:25Z date_updated: 2025-10-03T12:29:25Z embargo: 2026-10-03 embargo_to: open_access file_id: '20421' file_name: 2025_Lee_Seungho_Thesis__.pdf file_size: 14587276 relation: main_file file_date_updated: 2025-10-07T08:57:14Z has_accepted_license: '1' language: - iso: eng month: '10' oa_version: Published Version page: '144' project: - _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '15357' relation: part_of_dissertation status: public - id: '12237' relation: part_of_dissertation status: public status: public supervisor: - first_name: Maria full_name: Ibáñez, Maria id: 43C61214-F248-11E8-B48F-1D18A9856A87 last_name: Ibáñez orcid: 0000-0001-5013-2843 - first_name: Loredana full_name: Protesescu, Loredana last_name: Protesescu - first_name: Stefan Alexander full_name: Freunberger, Stefan Alexander id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425 last_name: Freunberger orcid: 0000-0003-2902-5319 title: Nanoparticle-based precursors toward advanced crystalline inorganic solids type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20364' acknowledged_ssus: - _id: LifeSc - _id: Bio acknowledgement: "Plant Facility,\r\nProtein Service Facility" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Caterina full_name: Giannini, Caterina id: e3fdddd5-f6e0-11ea-865d-ca99ee6367f4 last_name: Giannini citation: ama: Giannini C. Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. 2025. doi:10.15479/AT-ISTA-20364 apa: Giannini, C. (2025). Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20364 chicago: Giannini, Caterina. “Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20364. ieee: C. Giannini, “Nuclear and cell surface auxin signaling in A. thaliana developmental transitions,” Institute of Science and Technology Austria, 2025. ista: Giannini C. 2025. Nuclear and cell surface auxin signaling in A. thaliana developmental transitions. Institute of Science and Technology Austria. mla: Giannini, Caterina. Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20364. short: C. Giannini, Nuclear and Cell Surface Auxin Signaling in A. Thaliana Developmental Transitions, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-09-19T12:23:38Z date_published: 2025-09-19T00:00:00Z date_updated: 2026-04-07T11:52:16Z day: '19' ddc: - '580' degree_awarded: PhD department: - _id: GradSch - _id: JiFr - _id: MaLo doi: 10.15479/AT-ISTA-20364 file: - access_level: closed checksum: 536ba1701453b0b2346be14c046b2911 content_type: application/pdf creator: cgiannin date_created: 2025-09-24T14:46:34Z date_updated: 2025-09-30T14:31:29Z embargo: 2026-09-30 embargo_to: open_access file_id: '20390' file_name: 2025_Giannini_Caterina_Thesis...pdf file_size: 14278965 relation: main_file - access_level: closed checksum: 192f55262f2da2ea0a59d9c23a1b8573 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: cgiannin date_created: 2025-09-24T14:46:35Z date_updated: 2025-09-24T14:46:35Z file_id: '20391' file_name: 2025_Giannini_Caterina_Thesis...docx file_size: 24499022 relation: source_file file_date_updated: 2025-09-30T14:31:29Z has_accepted_license: '1' keyword: - Auxin Signaling - Plant Development language: - iso: eng month: '09' oa_version: Published Version page: '151' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '12291' relation: part_of_dissertation status: public - id: '19399' relation: part_of_dissertation status: public status: public supervisor: - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 title: Nuclear and cell surface auxin signaling in A. thaliana developmental transitions type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20441' abstract: - lang: eng text: "Epithelial spreading plays a pivotal role in the development of organisms especially those\r\nsuch as zebrafish which require the epithelial enveloping layer (EVL) to spread to cover the\r\nsubstantial yolk surface during gastrulation. Epiboly requires the transition of the epithelium\r\nwith cuboidal cells to form a thin, flat squamous epithelial sheet. During this transition, the\r\ncells show tissue-scale mechanosensation with mechanisms such as direct mechanical control\r\nover the axis of cell division.\r\nCytoskeletal intermediate filaments play a crucial role in vertebrate cells, not only facilitating\r\nmechanical stability but also helping facilitate the mechanosensitive response of the cell.\r\nMechanosenstivity displayed by intermediate filaments is due not just to their interesting\r\nphysical properties but also to their interactions with other cytoskeletal elements such as actin\r\nand microtubules. Keratin is the predominant intermediate filament expressed in the EVL.\r\nIt expresses concomitantly with the gastrulation movements of the developing embryo. Our\r\nwork focuses on understanding the role and dynamics of the keratin cytoskeletal network in\r\nmodulating the physical aspects of EVL spreading. We demonstrated with the combination of\r\nphysical characterisation and manipulations of the EVL, utilising a variety of biophysical tools\r\nand microscopy, the mechanistic role of keratin in tissue spreading.\r\nGenerating novel genetic morphants and mutants, we probe the effect that the loss of the\r\nkeratin network has on the physiology of the epithelium and the developing embryo. We\r\nshow that the changing organisation of the keratin network is important for changing EVL\r\nphysical properties as the stress imposed on the EVL increases during epiboly. By modelling\r\nthe epithelium, we study how the mechanical heterogeneity in an epithelium can feed back into\r\na mechanical loop to the maturation of the keratin network and hence affect the mechanics\r\nof the epithelium. However, unlike what would be predicted by the effect of intermediate\r\nfilaments in acting as a security belt and increasing the resistance of the epithelium, we observe\r\nthat loss of keratin leads to a delay in the EVL movement. Using both local aspirations of the\r\nYSL and EVL ablations, we demonstrate the mechanistic facilitation of actin mechanosensation\r\nin a keratin-dependent manner.\r\nFurthermore, using chemical inhibitors of microtubule polymerisation, we provide insight into\r\nthe mechanisms underlying the organisation and distribution of keratin. Interestingly, the\r\nphenotype observed upon this loss of microtubules shows that keratins interact with the nucleus\r\nthrough microtubular interactions. Together with these diverse observations, we describe\r\nthe mechanosensory feedback between resilience and that is critical for uniform and robust\r\nspreading of the epithelium." acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: "I would also like to thank the LSF and Cryo facility at ISTA, which have been helpful in my\r\nexperiments. I would also like to acknowledge FWF, grant DOI 10.55776/PAT5044023 and JKU Nanocell grant DOI \r\n10.55776/W1250 for providing funding for my PhD research. EMBO and FWF for providing funding for travel grants to attend conferences." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Suyash full_name: Naik, Suyash id: 2C0B105C-F248-11E8-B48F-1D18A9856A87 last_name: Naik orcid: 0000-0001-8421-5508 citation: ama: Naik S. Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. 2025. doi:10.15479/AT-ISTA-20441 apa: Naik, S. (2025). Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20441 chicago: Naik, Suyash. “Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20441. ieee: S. Naik, “Keratins act as global coordinators of tissue spreading through mechanosensitive feedback,” Institute of Science and Technology Austria, 2025. ista: Naik S. 2025. Keratins act as global coordinators of tissue spreading through mechanosensitive feedback. Institute of Science and Technology Austria. mla: Naik, Suyash. Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20441. short: S. Naik, Keratins Act as Global Coordinators of Tissue Spreading through Mechanosensitive Feedback, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-10-10T14:58:30Z date_published: 2025-10-12T00:00:00Z date_updated: 2026-04-07T11:58:57Z day: '12' ddc: - '596' - '597' - '532' degree_awarded: PhD department: - _id: GradSch - _id: CaHe - _id: EdHa doi: 10.15479/AT-ISTA-20441 file: - access_level: open_access checksum: 2892f04d4a5c18677871c3e06ac1244a content_type: application/pdf creator: snaik date_created: 2025-10-28T13:10:08Z date_updated: 2025-10-28T13:10:08Z file_id: '20567' file_name: Thesis_PDFA_.pdf file_size: 6846189 relation: main_file success: 1 - access_level: open_access checksum: 15934d4465cd0e9b7c32678da9a33a2f content_type: application/zip creator: snaik date_created: 2025-10-28T13:10:26Z date_updated: 2025-10-28T13:10:26Z file_id: '20568' file_name: Thesis.zip file_size: 8839300 relation: source_file file_date_updated: 2025-10-28T13:10:26Z has_accepted_license: '1' language: - iso: eng month: '10' oa: 1 oa_version: Published Version page: '105' project: - _id: 8f060199-16d5-11f0-9cad-f3253b266c46 grant_number: PAT 5044023 name: Keratins in epithelial tissue spreading - _id: 25AA5F24-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W 1250-B20 name: Nano-Analytics of Cellular Systems publication_identifier: isbn: - 978-3-99078-069-5 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '20465' relation: part_of_dissertation status: public status: public supervisor: - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: Edouard B full_name: Hannezo, Edouard B id: 3A9DB764-F248-11E8-B48F-1D18A9856A87 last_name: Hannezo orcid: 0000-0001-6005-1561 title: Keratins act as global coordinators of tissue spreading through mechanosensitive feedback tmp: image: /images/cc_by_sa.png legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0) short: CC BY-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20485' acknowledged_ssus: - _id: LifeSc - _id: Bio acknowledgement: "I would also like to acknowledge the funding that I received from the European Union’s\r\nHorizon 2020 research and Innovation programme under the Marie Sklodowska-Curie\r\nGrant Agreement No. 665385. This work would not have been possible without the contribution and support of people\r\nbehind the scientific service units at ISTA: the Life Science Facility (LSF), Imaging and\r\nOptics Facility (IOF), the Bioinformatics Unit, Protein Services Unit and\r\nElectrophysiology Unit. I would also like to recognize the work of people at the Vienna\r\nBiocenter (VBC) Mass Spectrometry Facility, particularly Markus Hartl and WeiQiang\r\nChen. " alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Michaela full_name: Misova, Michaela id: 495A3C32-F248-11E8-B48F-1D18A9856A87 last_name: Misova orcid: 0000-0003-2427-6856 citation: ama: Misova M. Dissecting gap junction biology using the C. elegans nervous system. 2025. doi:10.15479/AT-ISTA-20485 apa: Misova, M. (2025). Dissecting gap junction biology using the C. elegans nervous system. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20485 chicago: Misova, Michaela. “Dissecting Gap Junction Biology Using the C. Elegans Nervous System.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20485. ieee: M. Misova, “Dissecting gap junction biology using the C. elegans nervous system,” Institute of Science and Technology Austria, 2025. ista: Misova M. 2025. Dissecting gap junction biology using the C. elegans nervous system. Institute of Science and Technology Austria. mla: Misova, Michaela. Dissecting Gap Junction Biology Using the C. Elegans Nervous System. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20485. short: M. Misova, Dissecting Gap Junction Biology Using the C. Elegans Nervous System, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-10-17T16:15:09Z date_published: 2025-10-23T00:00:00Z date_updated: 2026-04-07T11:54:00Z day: '23' ddc: - '570' degree_awarded: PhD department: - _id: GradSch - _id: MaDe doi: 10.15479/AT-ISTA-20485 ec_funded: 1 file: - access_level: closed checksum: e042ea314e7e13fce76c6c95e126779a content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: mmisova date_created: 2025-10-23T08:22:35Z date_updated: 2025-11-06T11:08:06Z file_id: '20518' file_name: 2025-Misova-Michaela-Thesis.docx file_size: 75070995 relation: source_file - access_level: closed checksum: fcd8973d6a025256eb0eb1a82c02172c content_type: application/pdf creator: mmisova date_created: 2025-10-23T08:21:21Z date_updated: 2025-10-23T08:21:21Z embargo: 2026-10-23 embargo_to: open_access file_id: '20519' file_name: 2025-Misova-Michaela-Thesis.pdf file_size: 10974630 relation: main_file file_date_updated: 2025-11-06T11:08:06Z has_accepted_license: '1' language: - iso: eng month: '10' oa_version: Published Version page: '155' project: - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program publication_identifier: isbn: - 978-3-99078-068-8 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria status: public supervisor: - first_name: Mario full_name: de Bono, Mario id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87 last_name: de Bono orcid: 0000-0001-8347-0443 title: Dissecting gap junction biology using the C. elegans nervous system tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ...