---
_id: '8931'
abstract:
- lang: eng
  text: "Auxin is a major plant growth regulator, but current models on auxin perception
    and signaling cannot explain the whole plethora of auxin effects, in particular
    those associated with rapid responses. A possible candidate for a component of
    additional auxin perception mechanisms is the AUXIN BINDING PROTEIN 1 (ABP1),
    whose function in planta remains unclear.\r\nHere we combined expression analysis
    with gain- and loss-of-function approaches to analyze the role of ABP1 in plant
    development. ABP1 shows a broad expression largely overlapping with, but not regulated
    by, transcriptional auxin response activity. Furthermore, ABP1 activity is not
    essential for the transcriptional auxin signaling. Genetic in planta analysis
    revealed that abp1 loss-of-function mutants show largely normal development with
    minor defects in bolting. On the other hand, ABP1 gain-of-function alleles show
    a broad range of growth and developmental defects, including root and hypocotyl
    growth and bending, lateral root and leaf development, bolting, as well as response
    to heat stress. At the cellular level, ABP1 gain-of-function leads to impaired
    auxin effect on PIN polar distribution and affects BFA-sensitive PIN intracellular
    aggregation.\r\nThe gain-of-function analysis suggests a broad, but still mechanistically
    unclear involvement of ABP1 in plant development, possibly masked in abp1 loss-of-function
    mutants by a functional redundancy."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We would like to acknowledge Bioimaging and Life Science Facilities
  at IST Austria for continuous support and also the Plant Sciences Core Facility
  of CEITEC Masaryk University for their support with obtaining a part of the scientific
  data. We gratefully acknowledge Lindy Abas for help with ABP1::GFP-ABP1 construct
  design. This project has received funding from the European Research Council (ERC)
  under the European Union’s Horizon 2020 research and innovation program [grant agreement
  no. 742985] and Austrian Science Fund (FWF) [I 3630-B25] to J.F.; DOC Fellowship
  of the Austrian Academy of Sciences to L.L.; the European Structural and Investment
  Funds, Operational Programme Research, Development and Education - Project „MSCAfellow@MUNI“
  [CZ.02.2.69/0.0/0.0/17_050/0008496] to M.P.. This project was also supported by
  the Czech Science Foundation [GA 20-20860Y] to M.Z and MEYS CR [project no.CZ.02.1.01/0.0/0.0/16_019/0000738]
  to M. Č.
article_number: '110750'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Zuzana
  full_name: Gelová, Zuzana
  id: 0AE74790-0E0B-11E9-ABC7-1ACFE5697425
  last_name: Gelová
  orcid: 0000-0003-4783-1752
- first_name: Michelle C
  full_name: Gallei, Michelle C
  id: 35A03822-F248-11E8-B48F-1D18A9856A87
  last_name: Gallei
  orcid: 0000-0003-1286-7368
- first_name: Markéta
  full_name: Pernisová, Markéta
  last_name: Pernisová
- first_name: Géraldine
  full_name: Brunoud, Géraldine
  last_name: Brunoud
- first_name: Xixi
  full_name: Zhang, Xixi
  id: 61A66458-47E9-11EA-85BA-8AEAAF14E49A
  last_name: Zhang
  orcid: 0000-0001-7048-4627
- first_name: Matous
  full_name: Glanc, Matous
  id: 1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
  last_name: Glanc
  orcid: 0000-0003-0619-7783
- first_name: Lanxin
  full_name: Li, Lanxin
  id: 367EF8FA-F248-11E8-B48F-1D18A9856A87
  last_name: Li
  orcid: 0000-0002-5607-272X
- first_name: Jaroslav
  full_name: Michalko, Jaroslav
  id: 483727CA-F248-11E8-B48F-1D18A9856A87
  last_name: Michalko
- first_name: Zlata
  full_name: Pavlovicova, Zlata
  last_name: Pavlovicova
- first_name: Inge
  full_name: Verstraeten, Inge
  id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
  last_name: Verstraeten
  orcid: 0000-0001-7241-2328
- first_name: Huibin
  full_name: Han, Huibin
  id: 31435098-F248-11E8-B48F-1D18A9856A87
  last_name: Han
- first_name: Jakub
  full_name: Hajny, Jakub
  id: 4800CC20-F248-11E8-B48F-1D18A9856A87
  last_name: Hajny
  orcid: 0000-0003-2140-7195
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Milada
  full_name: Čovanová, Milada
  last_name: Čovanová
- first_name: Marta
  full_name: Zwiewka, Marta
  last_name: Zwiewka
- first_name: Lukas
  full_name: Hörmayer, Lukas
  id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87
  last_name: Hörmayer
  orcid: 0000-0001-8295-2926
- first_name: Matyas
  full_name: Fendrych, Matyas
  id: 43905548-F248-11E8-B48F-1D18A9856A87
  last_name: Fendrych
  orcid: 0000-0002-9767-8699
- first_name: Tongda
  full_name: Xu, Tongda
  last_name: Xu
- first_name: Teva
  full_name: Vernoux, Teva
  last_name: Vernoux
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Gelová Z, Gallei MC, Pernisová M, et al. Developmental roles of auxin binding
    protein 1 in Arabidopsis thaliana. <i>Plant Science</i>. 2021;303. doi:<a href="https://doi.org/10.1016/j.plantsci.2020.110750">10.1016/j.plantsci.2020.110750</a>
  apa: Gelová, Z., Gallei, M. C., Pernisová, M., Brunoud, G., Zhang, X., Glanc, M.,
    … Friml, J. (2021). Developmental roles of auxin binding protein 1 in Arabidopsis
    thaliana. <i>Plant Science</i>. Elsevier. <a href="https://doi.org/10.1016/j.plantsci.2020.110750">https://doi.org/10.1016/j.plantsci.2020.110750</a>
  chicago: Gelová, Zuzana, Michelle C Gallei, Markéta Pernisová, Géraldine Brunoud,
    Xixi Zhang, Matous Glanc, Lanxin Li, et al. “Developmental Roles of Auxin Binding
    Protein 1 in Arabidopsis Thaliana.” <i>Plant Science</i>. Elsevier, 2021. <a href="https://doi.org/10.1016/j.plantsci.2020.110750">https://doi.org/10.1016/j.plantsci.2020.110750</a>.
  ieee: Z. Gelová <i>et al.</i>, “Developmental roles of auxin binding protein 1 in
    Arabidopsis thaliana,” <i>Plant Science</i>, vol. 303. Elsevier, 2021.
  ista: Gelová Z, Gallei MC, Pernisová M, Brunoud G, Zhang X, Glanc M, Li L, Michalko
    J, Pavlovicova Z, Verstraeten I, Han H, Hajny J, Hauschild R, Čovanová M, Zwiewka
    M, Hörmayer L, Fendrych M, Xu T, Vernoux T, Friml J. 2021. Developmental roles
    of auxin binding protein 1 in Arabidopsis thaliana. Plant Science. 303, 110750.
  mla: Gelová, Zuzana, et al. “Developmental Roles of Auxin Binding Protein 1 in Arabidopsis
    Thaliana.” <i>Plant Science</i>, vol. 303, 110750, Elsevier, 2021, doi:<a href="https://doi.org/10.1016/j.plantsci.2020.110750">10.1016/j.plantsci.2020.110750</a>.
  short: Z. Gelová, M.C. Gallei, M. Pernisová, G. Brunoud, X. Zhang, M. Glanc, L.
    Li, J. Michalko, Z. Pavlovicova, I. Verstraeten, H. Han, J. Hajny, R. Hauschild,
    M. Čovanová, M. Zwiewka, L. Hörmayer, M. Fendrych, T. Xu, T. Vernoux, J. Friml,
    Plant Science 303 (2021).
corr_author: '1'
date_created: 2020-12-09T14:48:28Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2026-04-28T22:31:06Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
- _id: Bio
doi: 10.1016/j.plantsci.2020.110750
ec_funded: 1
external_id:
  isi:
  - '000614154500001'
  pmid:
  - '33487339'
file:
- access_level: open_access
  checksum: a7f2562bdca62d67dfa88e271b62a629
  content_type: application/pdf
  creator: dernst
  date_created: 2021-02-04T07:49:25Z
  date_updated: 2021-02-04T07:49:25Z
  file_id: '9083'
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  relation: main_file
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file_date_updated: 2021-02-04T07:49:25Z
has_accepted_license: '1'
intvolume: '       303'
isi: 1
keyword:
- Agronomy and Crop Science
- Plant Science
- Genetics
- General Medicine
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742985'
  name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03630
  name: Molecular mechanisms of endocytic cargo recognition in plants
- _id: 26B4D67E-B435-11E9-9278-68D0E5697425
  grant_number: '25351'
  name: 'A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated
    Rapid Growth Inhibition in Arabidopsis Root'
publication: Plant Science
publication_identifier:
  issn:
  - 0168-9452
publication_status: published
publisher: Elsevier
quality_controlled: '1'
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  - id: '10083'
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scopus_import: '1'
status: public
title: Developmental roles of auxin binding protein 1 in Arabidopsis thaliana
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 303
year: '2021'
...