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We would like to thank Michael Sixt for discussions on this work and the Quidant, Ruprecht, and Wieser lab members for critical reading of the manuscript. This research was supported by the Scientific Service Units (SSU) of IST-Austria through resources provided by the Nanofabrication Facility (NFF). C.A. acknowledges the funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no 847517 and V.V. from the ICFOstepstone – PhD Programme funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no 665884. S.W. acknowledges support through the Spanish Ministry of Economy and Competitiveness via MINECO’s Plan Nacional (BFU2017-86296-P). V.R. acknowledges funding from the European Union’s HORIZON-EIC-2021-PATHFINDEROPEN program under grant agreement no. 101046620 and European Union's Horizon Europe program under the grant agreement no. 101072123. E.K. acknowledges funding by a fellowship of the Ministry of Innovation, Science and Research of North-Rhine-Westphalia (AZ: 421-8.03.03.02-137069) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC 2151 – 390873048 and by the TRA Life and Health (University of Bonn) as part of the Excellence Strategy of the federal and state governments.","OA_place":"publisher","PlanS_conform":"1","file_date_updated":"2026-07-23T06:26:25Z","title":"Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses","acknowledged_ssus":[{"_id":"NanoFab"}],"pmid":1,"citation":{"ista":"Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, Ciraulo B, Molkenbur R, Lanzerstorfer P, Pezzano F, Agazzi C, Hauschild R, Jain S, Jacques JM, Venturini V, Knapp C, Xie Y, Merrin J, Weghuber J, Schaaf M, Quidant R, Kiermaier E, Ortega Arroyo J, Ruprecht V, Wieser S. 2026. Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. Developmental Cell. 61(2), 356–371.e12.","chicago":"Company-Garrido, Iván, Alberto Zurita Carpio, Mariona Colomer-Rosell, Bernard Ciraulo, Ronja Molkenbur, Peter Lanzerstorfer, Fabio Pezzano, et al. “Myosin II Regulates Cellular Thermo-Adaptability and the Efficiency of Immune Responses.” <i>Developmental Cell</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.devcel.2025.10.006\">https://doi.org/10.1016/j.devcel.2025.10.006</a>.","ieee":"I. Company-Garrido <i>et al.</i>, “Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses,” <i>Developmental Cell</i>, vol. 61, no. 2. Elsevier, p. 356–371.e12, 2026.","short":"I. Company-Garrido, A. Zurita Carpio, M. Colomer-Rosell, B. Ciraulo, R. Molkenbur, P. Lanzerstorfer, F. Pezzano, C. Agazzi, R. Hauschild, S. Jain, J.M. Jacques, V. Venturini, C. Knapp, Y. Xie, J. Merrin, J. Weghuber, M. Schaaf, R. Quidant, E. Kiermaier, J. Ortega Arroyo, V. Ruprecht, S. Wieser, Developmental Cell 61 (2026) 356–371.e12.","mla":"Company-Garrido, Iván, et al. “Myosin II Regulates Cellular Thermo-Adaptability and the Efficiency of Immune Responses.” <i>Developmental Cell</i>, vol. 61, no. 2, Elsevier, 2026, p. 356–371.e12, doi:<a href=\"https://doi.org/10.1016/j.devcel.2025.10.006\">10.1016/j.devcel.2025.10.006</a>.","apa":"Company-Garrido, I., Zurita Carpio, A., Colomer-Rosell, M., Ciraulo, B., Molkenbur, R., Lanzerstorfer, P., … Wieser, S. (2026). Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2025.10.006\">https://doi.org/10.1016/j.devcel.2025.10.006</a>","ama":"Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, et al. Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. <i>Developmental Cell</i>. 2026;61(2):356-371.e12. doi:<a href=\"https://doi.org/10.1016/j.devcel.2025.10.006\">10.1016/j.devcel.2025.10.006</a>"},"_id":"20859","oa_version":"Published Version","date_updated":"2026-07-23T06:27:15Z","oa":1,"doi":"10.1016/j.devcel.2025.10.006","volume":61,"date_published":"2026-02-11T00:00:00Z","article_processing_charge":"Yes (in subscription journal)","intvolume":"        61","ddc":["570"],"publication":"Developmental Cell","OA_type":"hybrid","type":"journal_article","scopus_import":"1","article_type":"original","quality_controlled":"1","abstract":[{"lang":"eng","text":"Effective immune responses rely on the efficient migration of leukocytes. Yet, how temperature regulates migration dynamics at the single-cell level has remained poorly understood. Using zebrafish embryos and mouse tissue explants, we found that temperature positively regulates leukocyte migration speed, exploration, and arrival frequencies to wounds and lymph vessels. Complementary 2D and 3D cultures revealed that this thermokinetic control of cell migration is conserved across immune cell types, independently of the 3D tissue environment. By applying precise (sub-)cellular temperature modulation, we identified a rapid and reversible thermo-response that depends on myosin II activity. Small physiological increases in temperature (1°C –2°C), as present during fever-like conditions, profoundly increased immune responses by accelerating arrival times at lymphatic vessels and tissue wounds. These findings identify myosin-II-dependent actomyosin contractility as a critical mechanical structure regulating single-cell thermo-adaptability, with physiological implications for tuning the speed of immune responses in vivo."}],"publication_identifier":{"eissn":["1878-1551"],"issn":["1534-5807"]},"year":"2026","supplementarymaterial":"yes","file":[{"content_type":"application/pdf","success":1,"file_size":12342817,"creator":"dernst","checksum":"52fd52d2d19a4514f8fcc1b40f420ca2","date_created":"2026-07-23T06:26:25Z","relation":"main_file","file_name":"2026_DevelopmentalCell_CompanyGarrido.pdf","date_updated":"2026-07-23T06:26:25Z","access_level":"open_access","file_id":"22388"}],"page":"356-371.e12","researchdata_availability":"upon request","department":[{"_id":"Bio"},{"_id":"NanoFab"}],"date_created":"2025-12-28T23:01:27Z","language":[{"iso":"eng"}],"author":[{"last_name":"Company-Garrido","full_name":"Company-Garrido, Iván","first_name":"Iván"},{"first_name":"Alberto","full_name":"Zurita Carpio, Alberto","last_name":"Zurita Carpio"},{"last_name":"Colomer-Rosell","full_name":"Colomer-Rosell, Mariona","first_name":"Mariona"},{"first_name":"Bernard","full_name":"Ciraulo, Bernard","last_name":"Ciraulo"},{"first_name":"Ronja","last_name":"Molkenbur","full_name":"Molkenbur, Ronja"},{"full_name":"Lanzerstorfer, Peter","last_name":"Lanzerstorfer","first_name":"Peter"},{"full_name":"Pezzano, Fabio","last_name":"Pezzano","first_name":"Fabio"},{"first_name":"Costanza","full_name":"Agazzi, Costanza","last_name":"Agazzi"},{"last_name":"Hauschild","orcid":"0000-0001-9843-3522","full_name":"Hauschild, Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"},{"last_name":"Jain","full_name":"Jain, Saumey","first_name":"Saumey"},{"full_name":"Jacques, Jeroen M.","last_name":"Jacques","first_name":"Jeroen M."},{"last_name":"Venturini","full_name":"Venturini, Valeria","first_name":"Valeria"},{"last_name":"Knapp","full_name":"Knapp, Christian","first_name":"Christian"},{"first_name":"Yufei","last_name":"Xie","full_name":"Xie, Yufei"},{"full_name":"Merrin, Jack","last_name":"Merrin","orcid":"0000-0001-5145-4609","first_name":"Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Weghuber","full_name":"Weghuber, Julian","first_name":"Julian"},{"first_name":"Marcel","last_name":"Schaaf","full_name":"Schaaf, Marcel"},{"full_name":"Quidant, Romain","last_name":"Quidant","first_name":"Romain"},{"first_name":"Eva","id":"3EB04B78-F248-11E8-B48F-1D18A9856A87","full_name":"Kiermaier, Eva","orcid":"0000-0001-6165-5738","last_name":"Kiermaier"},{"full_name":"Ortega Arroyo, Jaime","last_name":"Ortega Arroyo","first_name":"Jaime"},{"id":"4D71A03A-F248-11E8-B48F-1D18A9856A87","first_name":"Verena","orcid":"0000-0003-4088-8633","last_name":"Ruprecht","full_name":"Ruprecht, Verena"},{"id":"355AA5A0-F248-11E8-B48F-1D18A9856A87","first_name":"Stefan","orcid":"0000-0002-2670-2217","last_name":"Wieser","full_name":"Wieser, Stefan"}],"das_tickbox":"1","issue":"2","keyword":["thermobiology","cell migration","thermo-adaptability of immune cells"],"month":"02","dataavailabilitystatement":"This study did not generate new unique reagents. Data are available upon request.\r\n•The custom-made codes used in this study are available at: https://github.com/mcolomerr/cell_thermo https://github.com/Stefan1980sol/Lymph_entry_simu\r\n• Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request."},{"abstract":[{"lang":"eng","text":"Most motions of many-body systems at any scale in nature with sufficient degrees of freedom tend to be chaotic; reaching from the orbital motion of planets, the air currents in our atmosphere, down to the water flowing through our pipelines or the movement of a population of bacteria. To the observer it is therefore intriguing when a moving collective exhibits order. Collective motion of flocks of birds, schools of fish or swarms of self-propelled particles or robots have been studied extensively over the past decades but the mechanisms involved in the transition from chaos to order remain unclear. Here, the interactions, that in most systems give rise to chaos, sustain order.  In this thesis we investigate mechanisms that preserve, destabilize or lead to the ordered state. We show that endothelial cells migrating in circular confinements transition to a collective rotating state and concomitantly synchronize the frequencies of nucleating actin waves within individual cells. Consequently, the frequency dependent cell migration speed uniformizes across the population. Complementary to the WAVE dependent nucleation of traveling actin waves, we show that in leukocytes the actin polymerization depending on WASp generates pushing forces locally at stationary patches. Next, in pipe flows, we study methods to disrupt the self--sustaining cycle of turbulence and therefore relaminarize the flow. While we find in pulsating flow conditions that turbulence emerges through a helical instability during the decelerating phase. Finally, we show quantitatively in brain slices of mice that wild-type control neurons can compensate the migratory deficits of a genetically modified neuronal sub--population in the developing cortex.  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(2023). <i>Synchronization in collectively moving active matter</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/14530\">https://doi.org/10.15479/14530</a>","ama":"Riedl M. Synchronization in collectively moving active matter. 2023. doi:<a href=\"https://doi.org/10.15479/14530\">10.15479/14530</a>","chicago":"Riedl, Michael. “Synchronization in Collectively Moving Active Matter.” Institute of Science and Technology Austria, 2023. <a href=\"https://doi.org/10.15479/14530\">https://doi.org/10.15479/14530</a>.","ieee":"M. Riedl, “Synchronization in collectively moving active matter,” Institute of Science and Technology Austria, 2023.","ista":"Riedl M. 2023. Synchronization in collectively moving active matter. Institute of Science and Technology Austria.","mla":"Riedl, Michael. <i>Synchronization in Collectively Moving Active Matter</i>. Institute of Science and Technology Austria, 2023, doi:<a href=\"https://doi.org/10.15479/14530\">10.15479/14530</a>.","short":"M. Riedl, Synchronization in Collectively Moving Active Matter, Institute of Science and Technology Austria, 2023."},"related_material":{"record":[{"id":"461","status":"public","relation":"part_of_dissertation"},{"id":"10791","status":"public","relation":"part_of_dissertation"},{"status":"public","id":"7932","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"10703"},{"relation":"old_edition","id":"12726","status":"public"}]},"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"Bio"}],"degree_awarded":"PhD","title":"Synchronization in collectively moving active matter","file_date_updated":"2023-11-15T09:52:54Z","OA_place":"publisher"},{"doi":"10.21769/bioprotoc.3018","volume":8,"oa":1,"date_updated":"2025-05-20T07:43:06Z","article_processing_charge":"Yes","date_published":"2018-09-20T00:00:00Z","OA_type":"gold","type":"journal_article","DOAJ_listed":"1","publication":"Bio-Protocol","ddc":["570"],"corr_author":"1","intvolume":"         8","ec_funded":1,"abstract":[{"lang":"eng","text":"Blood platelets are critical for hemostasis and thrombosis, but also play diverse roles during immune responses. We have recently reported that platelets migrate at sites of infection in vitro and in vivo. Importantly, platelets use their ability to migrate to collect and bundle fibrin (ogen)-bound bacteria accomplishing efficient intravascular bacterial trapping. Here, we describe a method that allows analyzing platelet migration in vitro, focusing on their ability to collect bacteria and trap bacteria under flow."}],"quality_controlled":"1","article_type":"original","publication_identifier":{"issn":["2331-8325"]},"year":"2018","author":[{"first_name":"Shuxia","full_name":"Fan, Shuxia","last_name":"Fan"},{"first_name":"Michael","full_name":"Lorenz, Michael","last_name":"Lorenz"},{"first_name":"Steffen","last_name":"Massberg","full_name":"Massberg, Steffen"},{"id":"397A88EE-F248-11E8-B48F-1D18A9856A87","first_name":"Florian R","last_name":"Gärtner","orcid":"0000-0001-6120-3723","full_name":"Gärtner, Florian R"}],"language":[{"iso":"eng"}],"department":[{"_id":"MiSi"}],"date_created":"2019-04-29T09:40:33Z","file":[{"access_level":"open_access","file_id":"6360","date_updated":"2020-07-14T12:47:28Z","relation":"main_file","file_name":"2018_BioProtocol_Fan.pdf","date_created":"2019-04-30T08:04:33Z","creator":"dernst","checksum":"d4588377e789da7f360b553ae02c5119","content_type":"application/pdf","file_size":2928337}],"keyword":["Platelets","Cell migration","Bacteria","Shear flow","Fibrinogen","E. coli"],"month":"09","issue":"18","has_accepted_license":"1","status":"public","article_number":"e3018","publisher":"Bio-Protocol","external_id":{"pmid":["34395806"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publication_status":"published","acknowledgement":"This protocol was adapted from a previously published study (Gaertner et al., 2017). We thank Michael Lorenz for his excellent assistance in bacteria culture. This work was funded by the DFG SFB 914 (S.M. [B02 and Z01]), the DFG SFB 1123 (S.M. [B06]), the DFG FOR 2033 (S.M. and F.G.), the German Centre for Cardiovascular Research (DZHK) (MHA 1.4VD [S.M.]), FP7 program (project 260309, PRESTIGE [S.M.]), FöFoLe project 947 (F.G.), the Friedrich-Baur-Stiftung project 41/16 (F.G.), Marie Sklodowska Curie Individual Fellowship (EU project 747687, LamelliaActin [F.G.]).","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"20","title":"Platelet migration and bacterial trapping assay under flow","file_date_updated":"2020-07-14T12:47:28Z","OA_place":"publisher","citation":{"ama":"Fan S, Lorenz M, Massberg S, Gärtner FR. Platelet migration and bacterial trapping assay under flow. <i>Bio-Protocol</i>. 2018;8(18). doi:<a href=\"https://doi.org/10.21769/bioprotoc.3018\">10.21769/bioprotoc.3018</a>","apa":"Fan, S., Lorenz, M., Massberg, S., &#38; Gärtner, F. R. (2018). Platelet migration and bacterial trapping assay under flow. <i>Bio-Protocol</i>. Bio-Protocol. <a href=\"https://doi.org/10.21769/bioprotoc.3018\">https://doi.org/10.21769/bioprotoc.3018</a>","mla":"Fan, Shuxia, et al. “Platelet Migration and Bacterial Trapping Assay under Flow.” <i>Bio-Protocol</i>, vol. 8, no. 18, e3018, Bio-Protocol, 2018, doi:<a href=\"https://doi.org/10.21769/bioprotoc.3018\">10.21769/bioprotoc.3018</a>.","short":"S. Fan, M. Lorenz, S. Massberg, F.R. Gärtner, Bio-Protocol 8 (2018).","ista":"Fan S, Lorenz M, Massberg S, Gärtner FR. 2018. Platelet migration and bacterial trapping assay under flow. Bio-Protocol. 8(18), e3018.","ieee":"S. Fan, M. Lorenz, S. Massberg, and F. R. Gärtner, “Platelet migration and bacterial trapping assay under flow,” <i>Bio-Protocol</i>, vol. 8, no. 18. Bio-Protocol, 2018.","chicago":"Fan, Shuxia, Michael Lorenz, Steffen Massberg, and Florian R Gärtner. “Platelet Migration and Bacterial Trapping Assay under Flow.” <i>Bio-Protocol</i>. Bio-Protocol, 2018. <a href=\"https://doi.org/10.21769/bioprotoc.3018\">https://doi.org/10.21769/bioprotoc.3018</a>."},"pmid":1,"project":[{"name":"Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells","call_identifier":"H2020","grant_number":"747687","_id":"260AA4E2-B435-11E9-9278-68D0E5697425"}],"oa_version":"Published Version","_id":"6354"},{"type":"research_data","ddc":["570"],"abstract":[{"lang":"eng","text":"Matlab script to calculate the forward migration indexes (<d_y>/<L>) from TrackMate spot-statistics files."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"04","doi":"10.15479/AT:ISTA:75","has_accepted_license":"1","status":"public","publisher":"Institute of Science and Technology Austria","oa":1,"date_updated":"2024-02-21T13:47:14Z","license":"https://creativecommons.org/publicdomain/zero/1.0/","article_processing_charge":"No","date_published":"2017-10-04T00:00:00Z","tmp":{"short":"CC0 (1.0)","name":"Creative Commons Public Domain Dedication (CC0 1.0)","image":"/images/cc_0.png","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode"},"author":[{"id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","orcid":"0000-0001-9843-3522","last_name":"Hauschild","full_name":"Hauschild, Robert"}],"citation":{"apa":"Hauschild, R. (2017). Forward migration indexes. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:75\">https://doi.org/10.15479/AT:ISTA:75</a>","ama":"Hauschild R. Forward migration indexes. 2017. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:75\">10.15479/AT:ISTA:75</a>","chicago":"Hauschild, Robert. “Forward Migration Indexes.” Institute of Science and Technology Austria, 2017. <a href=\"https://doi.org/10.15479/AT:ISTA:75\">https://doi.org/10.15479/AT:ISTA:75</a>.","ieee":"R. Hauschild, “Forward migration indexes.” Institute of Science and Technology Austria, 2017.","ista":"Hauschild R. 2017. Forward migration indexes, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:75\">10.15479/AT:ISTA:75</a>.","short":"R. Hauschild, (2017).","mla":"Hauschild, Robert. <i>Forward Migration Indexes</i>. Institute of Science and Technology Austria, 2017, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:75\">10.15479/AT:ISTA:75</a>."},"date_created":"2018-12-12T12:31:35Z","department":[{"_id":"Bio"}],"datarep_id":"75","file":[{"file_id":"5596","access_level":"open_access","date_updated":"2020-07-14T12:47:04Z","file_name":"IST-2017-75-v1+1_FMI.m","relation":"main_file","date_created":"2018-12-12T13:02:29Z","checksum":"cb7a2fa622460eca6231d659ce590e32","creator":"system","content_type":"application/octet-stream","file_size":799}],"keyword":["Cell migration","tracking","forward migration index","FMI"],"month":"10","oa_version":"Published Version","_id":"5570","title":"Forward migration indexes","file_date_updated":"2020-07-14T12:47:04Z","year":"2017"},{"_id":"5555","oa_version":"Published Version","month":"07","keyword":["cell migration","wide field microscopy","FIJI"],"file":[{"file_id":"5621","access_level":"open_access","date_updated":"2020-07-14T12:47:02Z","file_name":"IST-2016-44-v1+1_migrationAnalyzer.zip","relation":"main_file","date_created":"2018-12-12T13:03:03Z","checksum":"9f96cddbcd4ed689f48712ffe234d5e5","creator":"system","file_size":20692,"content_type":"application/zip"}],"datarep_id":"44","department":[{"_id":"Bio"}],"date_created":"2018-12-12T12:31:31Z","citation":{"mla":"Hauschild, Robert. <i>Fiji Script to Determine Average Speed and Direction of Migration of Cells</i>. Institute of Science and Technology Austria, 2016, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:44\">10.15479/AT:ISTA:44</a>.","short":"R. Hauschild, (2016).","chicago":"Hauschild, Robert. “Fiji Script to Determine Average Speed and Direction of Migration of Cells.” Institute of Science and Technology Austria, 2016. <a href=\"https://doi.org/10.15479/AT:ISTA:44\">https://doi.org/10.15479/AT:ISTA:44</a>.","ieee":"R. Hauschild, “Fiji script to determine average speed and direction of migration of cells.” Institute of Science and Technology Austria, 2016.","ista":"Hauschild R. 2016. Fiji script to determine average speed and direction of migration of cells, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:44\">10.15479/AT:ISTA:44</a>.","ama":"Hauschild R. Fiji script to determine average speed and direction of migration of cells. 2016. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:44\">10.15479/AT:ISTA:44</a>","apa":"Hauschild, R. (2016). Fiji script to determine average speed and direction of migration of cells. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:44\">https://doi.org/10.15479/AT:ISTA:44</a>"},"author":[{"first_name":"Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","full_name":"Hauschild, Robert","last_name":"Hauschild","orcid":"0000-0001-9843-3522"}],"year":"2016","file_date_updated":"2020-07-14T12:47:02Z","title":"Fiji script to determine average speed and direction of migration of cells","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"08","abstract":[{"text":"This FIJI script calculates the population average of the migration speed as a function of time of all cells from wide field microscopy movies.","lang":"eng"}],"ddc":["570"],"type":"research_data","date_published":"2016-07-08T00:00:00Z","tmp":{"short":"CC0 (1.0)","name":"Creative Commons Public Domain Dedication (CC0 1.0)","image":"/images/cc_0.png","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode"},"article_processing_charge":"No","date_updated":"2024-02-21T13:50:06Z","oa":1,"publisher":"Institute of Science and Technology Austria","status":"public","doi":"10.15479/AT:ISTA:44","has_accepted_license":"1"}]
