[{"month":"01","ec_funded":1,"date_published":"2021-01-29T00:00:00Z","publication":"Physical Review Letters","date_updated":"2025-04-14T07:43:50Z","date_created":"2021-02-01T09:20:00Z","ddc":["530"],"day":"29","title":"Entanglement view of dynamical quantum phase transitions","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","scopus_import":"1","article_type":"original","year":"2021","license":"https://creativecommons.org/licenses/by/4.0/","abstract":[{"lang":"eng","text":"The analogy between an equilibrium partition function and the return probability in many-body unitary dynamics has led to the concept of dynamical quantum phase transition (DQPT). DQPTs are defined by nonanalyticities in the return amplitude and are present in many models. In some cases, DQPTs can be related to equilibrium concepts, such as order parameters, yet their universal description is an open question. In this Letter, we provide first steps toward a classification of DQPTs by using a matrix product state description of unitary dynamics in the thermodynamic limit. This allows us to distinguish the two limiting cases of “precession” and “entanglement” DQPTs, which are illustrated using an analytical description in the quantum Ising model. While precession DQPTs are characterized by a large entanglement gap and are semiclassical in their nature, entanglement DQPTs occur near avoided crossings in the entanglement spectrum and can be distinguished by a complex pattern of nonlocal correlations. We demonstrate the existence of precession and entanglement DQPTs beyond Ising models, discuss observables that can distinguish them, and relate their interplay to complex DQPT phenomenology."}],"publication_identifier":{"eissn":["1079-7114"],"issn":["0031-9007"]},"file":[{"checksum":"d9acbc502390ed7a97e631d23ae19ecd","creator":"dernst","file_name":"2021_PhysicalRevLett_DeNicola.pdf","content_type":"application/pdf","file_id":"9074","success":1,"date_updated":"2021-02-03T12:47:04Z","relation":"main_file","file_size":398075,"date_created":"2021-02-03T12:47:04Z","access_level":"open_access"}],"language":[{"iso":"eng"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"keyword":["General Physics and Astronomy"],"type":"journal_article","publication_status":"published","author":[{"last_name":"De Nicola","first_name":"Stefano","id":"42832B76-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4842-6671","full_name":"De Nicola, Stefano"},{"id":"36EBAD38-F248-11E8-B48F-1D18A9856A87","first_name":"Alexios","orcid":"0000-0002-8443-1064","full_name":"Michailidis, Alexios","last_name":"Michailidis"},{"last_name":"Serbyn","orcid":"0000-0002-2399-5827","full_name":"Serbyn, Maksym","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","first_name":"Maksym"}],"quality_controlled":"1","article_processing_charge":"Yes","article_number":"040602","has_accepted_license":"1","issue":"4","status":"public","acknowledgement":"S. D. N. acknowledges funding from the Institute of Science and Technology (IST) Austria and from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement No. 754411. A. M. and M. S. were supported by the European Research Council (ERC) under the European Union’s Horizon 2020 Research and\r\nInnovation Programme (Grant Agreement No. 850899).","doi":"10.1103/physrevlett.126.040602","intvolume":"       126","isi":1,"external_id":{"arxiv":["2008.04894"],"isi":["000613148200001"]},"publisher":"American Physical Society","arxiv":1,"project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"},{"_id":"23841C26-32DE-11EA-91FC-C7463DDC885E","grant_number":"850899","call_identifier":"H2020","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control"}],"department":[{"_id":"MaSe"}],"citation":{"ama":"De Nicola S, Michailidis A, Serbyn M. Entanglement view of dynamical quantum phase transitions. <i>Physical Review Letters</i>. 2021;126(4). doi:<a href=\"https://doi.org/10.1103/physrevlett.126.040602\">10.1103/physrevlett.126.040602</a>","short":"S. De Nicola, A. Michailidis, M. Serbyn, Physical Review Letters 126 (2021).","apa":"De Nicola, S., Michailidis, A., &#38; Serbyn, M. (2021). Entanglement view of dynamical quantum phase transitions. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevlett.126.040602\">https://doi.org/10.1103/physrevlett.126.040602</a>","chicago":"De Nicola, Stefano, Alexios Michailidis, and Maksym Serbyn. “Entanglement View of Dynamical Quantum Phase Transitions.” <i>Physical Review Letters</i>. American Physical Society, 2021. <a href=\"https://doi.org/10.1103/physrevlett.126.040602\">https://doi.org/10.1103/physrevlett.126.040602</a>.","ieee":"S. De Nicola, A. Michailidis, and M. Serbyn, “Entanglement view of dynamical quantum phase transitions,” <i>Physical Review Letters</i>, vol. 126, no. 4. American Physical Society, 2021.","ista":"De Nicola S, Michailidis A, Serbyn M. 2021. Entanglement view of dynamical quantum phase transitions. Physical Review Letters. 126(4), 040602.","mla":"De Nicola, Stefano, et al. “Entanglement View of Dynamical Quantum Phase Transitions.” <i>Physical Review Letters</i>, vol. 126, no. 4, 040602, American Physical Society, 2021, doi:<a href=\"https://doi.org/10.1103/physrevlett.126.040602\">10.1103/physrevlett.126.040602</a>."},"_id":"9048","oa":1,"oa_version":"Published Version","file_date_updated":"2021-02-03T12:47:04Z","volume":126},{"keyword":["General Engineering","General Physics and Astronomy","General Materials Science"],"abstract":[{"lang":"eng","text":"Cu2–xS has become one of the most promising thermoelectric materials for application in the middle-high temperature range. Its advantages include the abundance, low cost, and safety of its elements and a high performance at relatively elevated temperatures. However, stability issues limit its operation current and temperature, thus calling for the optimization of the material performance in the middle temperature range. Here, we present a synthetic protocol for large scale production of covellite CuS nanoparticles at ambient temperature and atmosphere, and using water as a solvent. The crystal phase and stoichiometry of the particles are afterward tuned through an annealing process at a moderate temperature under inert or reducing atmosphere. While annealing under argon results in Cu1.8S nanopowder with a rhombohedral crystal phase, annealing in an atmosphere containing hydrogen leads to tetragonal Cu1.96S. High temperature X-ray diffraction analysis shows the material annealed in argon to transform to the cubic phase at ca. 400 K, while the material annealed in the presence of hydrogen undergoes two phase transitions, first to hexagonal and then to the cubic structure. The annealing atmosphere, temperature, and time allow adjustment of the density of copper vacancies and thus tuning of the charge carrier concentration and material transport properties. In this direction, the material annealed under Ar is characterized by higher electrical conductivities but lower Seebeck coefficients than the material annealed in the presence of hydrogen. By optimizing the charge carrier concentration through the annealing time, Cu2–xS with record figures of merit in the middle temperature range, up to 1.41 at 710 K, is obtained. We finally demonstrate that this strategy, based on a low-cost and scalable solution synthesis process, is also suitable for the production of high performance Cu2–xS layers using high throughput and cost-effective printing technologies."}],"publication_identifier":{"eissn":["1936-086X"],"issn":["1936-0851"]},"main_file_link":[{"url":"https://upcommons.upc.edu/bitstream/handle/2117/363528/Pb%20mengyao.pdf?sequence=1&isAllowed=y","open_access":"1"}],"corr_author":"1","language":[{"iso":"eng"}],"day":"01","title":"Effect of the annealing atmosphere on crystal phase and thermoelectric properties of copper sulfide","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","year":"2021","scopus_import":"1","month":"03","date_published":"2021-03-01T00:00:00Z","publication":"ACS Nano","date_updated":"2024-10-09T21:04:04Z","date_created":"2021-03-10T20:12:45Z","page":"4967–4978","department":[{"_id":"MaIb"}],"citation":{"short":"M. Li, Y. Liu, Y. Zhang, X. Han, T. Zhang, Y. Zuo, C. Xie, K. Xiao, J. Arbiol, J. Llorca, M. Ibáñez, J. Liu, A. Cabot, ACS Nano 15 (2021) 4967–4978.","apa":"Li, M., Liu, Y., Zhang, Y., Han, X., Zhang, T., Zuo, Y., … Cabot, A. (2021). Effect of the annealing atmosphere on crystal phase and thermoelectric properties of copper sulfide. <i>ACS Nano</i>. American Chemical Society . <a href=\"https://doi.org/10.1021/acsnano.0c09866\">https://doi.org/10.1021/acsnano.0c09866</a>","ama":"Li M, Liu Y, Zhang Y, et al. Effect of the annealing atmosphere on crystal phase and thermoelectric properties of copper sulfide. <i>ACS Nano</i>. 2021;15(3):4967–4978. doi:<a href=\"https://doi.org/10.1021/acsnano.0c09866\">10.1021/acsnano.0c09866</a>","chicago":"Li, Mengyao, Yu Liu, Yu Zhang, Xu Han, Ting Zhang, Yong Zuo, Chenyang Xie, et al. “Effect of the Annealing Atmosphere on Crystal Phase and Thermoelectric Properties of Copper Sulfide.” <i>ACS Nano</i>. American Chemical Society , 2021. <a href=\"https://doi.org/10.1021/acsnano.0c09866\">https://doi.org/10.1021/acsnano.0c09866</a>.","ieee":"M. Li <i>et al.</i>, “Effect of the annealing atmosphere on crystal phase and thermoelectric properties of copper sulfide,” <i>ACS Nano</i>, vol. 15, no. 3. American Chemical Society , pp. 4967–4978, 2021.","mla":"Li, Mengyao, et al. “Effect of the Annealing Atmosphere on Crystal Phase and Thermoelectric Properties of Copper Sulfide.” <i>ACS Nano</i>, vol. 15, no. 3, American Chemical Society , 2021, pp. 4967–4978, doi:<a href=\"https://doi.org/10.1021/acsnano.0c09866\">10.1021/acsnano.0c09866</a>.","ista":"Li M, Liu Y, Zhang Y, Han X, Zhang T, Zuo Y, Xie C, Xiao K, Arbiol J, Llorca J, Ibáñez M, Liu J, Cabot A. 2021. Effect of the annealing atmosphere on crystal phase and thermoelectric properties of copper sulfide. ACS Nano. 15(3), 4967–4978."},"oa":1,"_id":"9235","oa_version":"Submitted Version","volume":15,"external_id":{"pmid":["33645986"],"isi":["000634569100106"]},"publisher":"American Chemical Society ","acknowledgement":"This work was supported by the European Regional Development Funds. M.Y.L., X.H., T.Z., and K.X. thank the China Scholarship Council for scholarship support. M.I. acknowledges financial support from IST Austria. J.L. acknowledges support from the National Natural Science Foundation of China (No. 22008091), the funding for scientific research startup of Jiangsu University (No. 19JDG044), and Jiangsu Provincial Program for High-Level Innovative and Entrepreneurial Talents Introduction. J.L. is a Serra Húnter fellow and is grateful to the ICREA Academia program and projects MICINN/FEDER RTI2018-093996-B-C31 and GC 2017 SGR 128. ICN2 acknowledges funding from Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO ENE2017-85087-C3. ICN2 is supported by the Severo Ochoa program from Spanish MINECO (Grant No. SEV-2017-0706) and is funded by the CERCA Programme/Generalitat de Catalunya. Part of the present work has been performed in the framework of Universitat Autònoma de Barcelona Materials Science PhD program. T.Z. has received funding from the CSC-UAB PhD scholarship program.","status":"public","issue":"3","doi":"10.1021/acsnano.0c09866","intvolume":"        15","isi":1,"type":"journal_article","publication_status":"published","author":[{"last_name":"Li","first_name":"Mengyao","full_name":"Li, Mengyao"},{"last_name":"Liu","full_name":"Liu, Yu","orcid":"0000-0001-7313-6740","first_name":"Yu","id":"2A70014E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Zhang, Yu","first_name":"Yu","last_name":"Zhang"},{"full_name":"Han, Xu","first_name":"Xu","last_name":"Han"},{"full_name":"Zhang, Ting","first_name":"Ting","last_name":"Zhang"},{"full_name":"Zuo, Yong","first_name":"Yong","last_name":"Zuo"},{"last_name":"Xie","first_name":"Chenyang","full_name":"Xie, Chenyang"},{"last_name":"Xiao","full_name":"Xiao, Ke","first_name":"Ke"},{"last_name":"Arbiol","first_name":"Jordi","full_name":"Arbiol, Jordi"},{"first_name":"Jordi","full_name":"Llorca, Jordi","last_name":"Llorca"},{"last_name":"Ibáñez","orcid":"0000-0001-5013-2843","full_name":"Ibáñez, Maria","id":"43C61214-F248-11E8-B48F-1D18A9856A87","first_name":"Maria"},{"last_name":"Liu","full_name":"Liu, Junfeng","first_name":"Junfeng"},{"last_name":"Cabot","first_name":"Andreu","full_name":"Cabot, Andreu"}],"pmid":1,"quality_controlled":"1","article_processing_charge":"No"},{"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"LifeSc"},{"_id":"EM-Fac"}],"publisher":"Nature Research","external_id":{"isi":["000659145000011"]},"oa_version":"Published Version","_id":"9431","oa":1,"file_date_updated":"2021-06-09T15:21:14Z","volume":12,"citation":{"ieee":"M. Obr <i>et al.</i>, “Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer,” <i>Nature Communications</i>, vol. 12, no. 1. Nature Research, 2021.","ista":"Obr M, Ricana CL, Nikulin N, Feathers J-PR, Klanschnig M, Thader A, Johnson MC, Vogt VM, Schur FK, Dick RA. 2021. Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer. Nature Communications. 12(1), 3226.","mla":"Obr, Martin, et al. “Structure of the Mature Rous Sarcoma Virus Lattice Reveals a Role for IP6 in the Formation of the Capsid Hexamer.” <i>Nature Communications</i>, vol. 12, no. 1, 3226, Nature Research, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-23506-0\">10.1038/s41467-021-23506-0</a>.","short":"M. Obr, C.L. Ricana, N. Nikulin, J.-P.R. Feathers, M. Klanschnig, A. Thader, M.C. Johnson, V.M. Vogt, F.K. Schur, R.A. Dick, Nature Communications 12 (2021).","ama":"Obr M, Ricana CL, Nikulin N, et al. Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-23506-0\">10.1038/s41467-021-23506-0</a>","apa":"Obr, M., Ricana, C. L., Nikulin, N., Feathers, J.-P. R., Klanschnig, M., Thader, A., … Dick, R. A. (2021). Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer. <i>Nature Communications</i>. Nature Research. <a href=\"https://doi.org/10.1038/s41467-021-23506-0\">https://doi.org/10.1038/s41467-021-23506-0</a>","chicago":"Obr, Martin, Clifton L. Ricana, Nadia Nikulin, Jon-Philip R. Feathers, Marco Klanschnig, Andreas Thader, Marc C. Johnson, Volker M. Vogt, Florian KM Schur, and Robert A. Dick. “Structure of the Mature Rous Sarcoma Virus Lattice Reveals a Role for IP6 in the Formation of the Capsid Hexamer.” <i>Nature Communications</i>. Nature Research, 2021. <a href=\"https://doi.org/10.1038/s41467-021-23506-0\">https://doi.org/10.1038/s41467-021-23506-0</a>."},"department":[{"_id":"FlSc"}],"project":[{"call_identifier":"FWF","name":"Structural conservation and diversity in retroviral capsid","grant_number":"P31445","_id":"26736D6A-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","article_processing_charge":"No","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/how-retroviruses-become-infectious/","description":"News on IST Homepage"}]},"article_number":"3226","type":"journal_article","publication_status":"published","author":[{"last_name":"Obr","orcid":"0000-0003-1756-6564","full_name":"Obr, Martin","first_name":"Martin","id":"4741CA5A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Ricana, Clifton L.","first_name":"Clifton L.","last_name":"Ricana"},{"last_name":"Nikulin","first_name":"Nadia","full_name":"Nikulin, Nadia"},{"last_name":"Feathers","first_name":"Jon-Philip R.","full_name":"Feathers, Jon-Philip R."},{"last_name":"Klanschnig","full_name":"Klanschnig, Marco","first_name":"Marco"},{"first_name":"Andreas","id":"3A18A7B8-F248-11E8-B48F-1D18A9856A87","full_name":"Thader, Andreas","last_name":"Thader"},{"last_name":"Johnson","first_name":"Marc C.","full_name":"Johnson, Marc C."},{"last_name":"Vogt","full_name":"Vogt, Volker M.","first_name":"Volker M."},{"full_name":"Schur, Florian KM","orcid":"0000-0003-4790-8078","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","first_name":"Florian KM","last_name":"Schur"},{"first_name":"Robert A.","full_name":"Dick, Robert A.","last_name":"Dick"}],"intvolume":"        12","doi":"10.1038/s41467-021-23506-0","isi":1,"issue":"1","has_accepted_license":"1","acknowledgement":"This work was funded by the National Institute of Allergy and Infectious Diseases under awards R01AI147890 to R.A.D., R01AI150454 to V.M.V, R35GM136258 in support of J-P.R.F, and the Austrian Science Fund (FWF) grant P31445 to F.K.M.S. Access to high-resolution cryo-ET data acquisition at EMBL Heidelberg was supported by iNEXT (grant no. 653706), funded by the Horizon 2020 program of the European Union (PID 4246). We thank Wim Hagen and Felix Weis at EMBL Heidelberg for support in cryo-ET data acquisition. This work made use of the Cornell Center for Materials Research Shared Facilities, which are supported through the NSF MRSEC program (DMR-179875). This research was also supported by the Scientific Service Units (SSUs) of IST Austria through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), and the Electron Microscopy Facility (EMF).","status":"public","corr_author":"1","language":[{"iso":"eng"}],"abstract":[{"text":"Inositol hexakisphosphate (IP6) is an assembly cofactor for HIV-1. We report here that IP6 is also used for assembly of Rous sarcoma virus (RSV), a retrovirus from a different genus. IP6 is ~100-fold more potent at promoting RSV mature capsid protein (CA) assembly than observed for HIV-1 and removal of IP6 in cells reduces infectivity by 100-fold. Here, visualized by cryo-electron tomography and subtomogram averaging, mature capsid-like particles show an IP6-like density in the CA hexamer, coordinated by rings of six lysines and six arginines. Phosphate and IP6 have opposing effects on CA in vitro assembly, inducing formation of T = 1 icosahedrons and tubes, respectively, implying that phosphate promotes pentamer and IP6 hexamer formation. Subtomogram averaging and classification optimized for analysis of pleomorphic retrovirus particles reveal that the heterogeneity of mature RSV CA polyhedrons results from an unexpected, intrinsic CA hexamer flexibility. In contrast, the CA pentamer forms rigid units organizing the local architecture. These different features of hexamers and pentamers determine the structural mechanism to form CA polyhedrons of variable shape in mature RSV particles.","lang":"eng"}],"publication_identifier":{"eissn":["2041-1723"]},"file":[{"file_name":"2021_NatureCommunications_Obr.pdf","checksum":"53ccc53d09a9111143839dbe7784e663","creator":"kschuh","content_type":"application/pdf","success":1,"file_id":"9538","file_size":6166295,"relation":"main_file","date_updated":"2021-06-09T15:21:14Z","date_created":"2021-06-09T15:21:14Z","access_level":"open_access"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"date_created":"2021-05-28T14:25:50Z","date_updated":"2025-04-15T08:24:49Z","publication":"Nature Communications","ddc":["570"],"month":"05","date_published":"2021-05-28T00:00:00Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","scopus_import":"1","year":"2021","article_type":"original","day":"28","title":"Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer"},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","scopus_import":"1","year":"2021","article_type":"original","day":"09","title":"Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine","date_created":"2021-06-10T14:57:45Z","publication":"Nature Communications","date_updated":"2024-10-21T06:02:01Z","ddc":["570"],"month":"06","date_published":"2021-06-09T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["2041-1723"]},"abstract":[{"lang":"eng","text":"The hexameric AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis and initiates cytoplasmic maturation of the large ribosomal subunit by releasing the shuttling maturation factor Rlp24. Drg1 monomers contain two AAA-domains (D1 and D2) that act in a concerted manner. Rlp24 release is inhibited by the drug diazaborine which blocks ATP hydrolysis in D2. The mode of inhibition was unknown. Here we show the first cryo-EM structure of Drg1 revealing the inhibitory mechanism. Diazaborine forms a covalent bond to the 2′-OH of the nucleotide in D2, explaining its specificity for this site. As a consequence, the D2 domain is locked in a rigid, inactive state, stalling the whole Drg1 hexamer. Resistance mechanisms identified include abolished drug binding and altered positioning of the nucleotide. Our results suggest nucleotide-modifying compounds as potential novel inhibitors for AAA-ATPases."}],"file":[{"relation":"main_file","date_updated":"2021-06-15T18:55:59Z","file_size":3397292,"access_level":"open_access","date_created":"2021-06-15T18:55:59Z","checksum":"40fc24c1310930990b52a8ad1142ee97","creator":"cziletti","file_name":"2021_NatureComm_Prattes.pdf","content_type":"application/pdf","success":1,"file_id":"9556"}],"intvolume":"        12","doi":"10.1038/s41467-021-23854-x","isi":1,"acknowledgement":"We are deeply grateful to the late Gregor Högenauer who built the foundation for this study with his visionary work on the inhibitor diazaborine and its bacterial target. We thank Rolf Breinbauer for insightful discussions on boron chemistry. We thank Anton Meinhart and Tim Clausen for the valuable discussion of the manuscript. We are indebted to Thomas Köcher for the MS measurement of the diazaborine-ATPγS adduct. We thank the team of the VBCF for support during early phases of this work and the IST Austria Electron Microscopy Facility for providing equipment. The lab of D.H. is supported by Boehringer Ingelheim. The work was funded by FWF projects P32536 and P32977 (to H.B.).","status":"public","issue":"1","has_accepted_license":"1","article_processing_charge":"No","quality_controlled":"1","pmid":1,"article_number":"3483","type":"journal_article","publication_status":"published","author":[{"last_name":"Prattes","first_name":"Michael","full_name":"Prattes, Michael"},{"last_name":"Grishkovskaya","full_name":"Grishkovskaya, Irina","first_name":"Irina"},{"id":"3661B498-F248-11E8-B48F-1D18A9856A87","first_name":"Victor-Valentin","orcid":"0000-0003-3904-947X","full_name":"Hodirnau, Victor-Valentin","last_name":"Hodirnau"},{"first_name":"Ingrid","full_name":"Rössler, Ingrid","last_name":"Rössler"},{"last_name":"Klein","full_name":"Klein, Isabella","first_name":"Isabella"},{"last_name":"Hetzmannseder","full_name":"Hetzmannseder, Christina","first_name":"Christina"},{"first_name":"Gertrude","full_name":"Zisser, Gertrude","last_name":"Zisser"},{"full_name":"Gruber, Christian C.","first_name":"Christian C.","last_name":"Gruber"},{"last_name":"Gruber","full_name":"Gruber, Karl","first_name":"Karl"},{"last_name":"Haselbach","first_name":"David","full_name":"Haselbach, David"},{"first_name":"Helmut","full_name":"Bergler, Helmut","last_name":"Bergler"}],"oa_version":"Published Version","_id":"9540","oa":1,"volume":12,"file_date_updated":"2021-06-15T18:55:59Z","citation":{"chicago":"Prattes, Michael, Irina Grishkovskaya, Victor-Valentin Hodirnau, Ingrid Rössler, Isabella Klein, Christina Hetzmannseder, Gertrude Zisser, et al. “Structural Basis for Inhibition of the AAA-ATPase Drg1 by Diazaborine.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-23854-x\">https://doi.org/10.1038/s41467-021-23854-x</a>.","apa":"Prattes, M., Grishkovskaya, I., Hodirnau, V.-V., Rössler, I., Klein, I., Hetzmannseder, C., … Bergler, H. (2021). Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-23854-x\">https://doi.org/10.1038/s41467-021-23854-x</a>","ama":"Prattes M, Grishkovskaya I, Hodirnau V-V, et al. Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-23854-x\">10.1038/s41467-021-23854-x</a>","short":"M. Prattes, I. Grishkovskaya, V.-V. Hodirnau, I. Rössler, I. Klein, C. Hetzmannseder, G. Zisser, C.C. Gruber, K. Gruber, D. Haselbach, H. Bergler, Nature Communications 12 (2021).","mla":"Prattes, Michael, et al. “Structural Basis for Inhibition of the AAA-ATPase Drg1 by Diazaborine.” <i>Nature Communications</i>, vol. 12, no. 1, 3483, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-23854-x\">10.1038/s41467-021-23854-x</a>.","ista":"Prattes M, Grishkovskaya I, Hodirnau V-V, Rössler I, Klein I, Hetzmannseder C, Zisser G, Gruber CC, Gruber K, Haselbach D, Bergler H. 2021. Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine. Nature Communications. 12(1), 3483.","ieee":"M. Prattes <i>et al.</i>, “Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021."},"department":[{"_id":"EM-Fac"}],"acknowledged_ssus":[{"_id":"EM-Fac"}],"publisher":"Springer Nature","external_id":{"isi":["000664874700014"],"pmid":["34108481"]}},{"OA_type":"gold","file":[{"date_created":"2021-12-17T11:34:50Z","access_level":"open_access","relation":"main_file","file_size":3108845,"date_updated":"2021-12-17T11:34:50Z","success":1,"file_id":"10563","content_type":"application/pdf","file_name":"2021_NatureCommunications_Vandael.pdf","creator":"kschuh","checksum":"6036a8cdae95e1707c2a04d54e325ff4"}],"publication_identifier":{"issn":["2041-1723"]},"abstract":[{"lang":"eng","text":"The hippocampal mossy fiber synapse is a key synapse of the trisynaptic circuit. Post-tetanic potentiation (PTP) is the most powerful form of plasticity at this synaptic connection. It is widely believed that mossy fiber PTP is an entirely presynaptic phenomenon, implying that PTP induction is input-specific, and requires neither activity of multiple inputs nor stimulation of postsynaptic neurons. To directly test cooperativity and associativity, we made paired recordings between single mossy fiber terminals and postsynaptic CA3 pyramidal neurons in rat brain slices. By stimulating non-overlapping mossy fiber inputs converging onto single CA3 neurons, we confirm that PTP is input-specific and non-cooperative. Unexpectedly, mossy fiber PTP exhibits anti-associative induction properties. EPSCs show only minimal PTP after combined pre- and postsynaptic high-frequency stimulation with intact postsynaptic Ca2+ signaling, but marked PTP in the absence of postsynaptic spiking and after suppression of postsynaptic Ca2+ signaling (10 mM EGTA). PTP is largely recovered by inhibitors of voltage-gated R- and L-type Ca2+ channels, group II mGluRs, and vacuolar-type H+-ATPase, suggesting the involvement of retrograde vesicular glutamate signaling. Transsynaptic regulation of PTP extends the repertoire of synaptic computations, implementing a brake on mossy fiber detonation and a “smart teacher” function of hippocampal mossy fiber synapses."}],"language":[{"iso":"eng"}],"corr_author":"1","keyword":["general physics and astronomy","general biochemistry","genetics and molecular biology","general chemistry"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2021-05-18T00:00:00Z","ec_funded":1,"month":"05","ddc":["570"],"date_created":"2021-08-06T07:22:55Z","publication":"Nature Communications","date_updated":"2025-06-12T06:28:45Z","title":"Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses","day":"18","article_type":"original","scopus_import":"1","year":"2021","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer","external_id":{"isi":["000655481800014"],"pmid":["34006874"]},"acknowledged_ssus":[{"_id":"SSU"}],"citation":{"ieee":"D. H. Vandael, Y. Okamoto, and P. M. Jonas, “Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses,” <i>Nature Communications</i>, vol. 12, no. 1. Springer, 2021.","mla":"Vandael, David H., et al. “Transsynaptic Modulation of Presynaptic Short-Term Plasticity in Hippocampal Mossy Fiber Synapses.” <i>Nature Communications</i>, vol. 12, no. 1, 2912, Springer, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-23153-5\">10.1038/s41467-021-23153-5</a>.","ista":"Vandael DH, Okamoto Y, Jonas PM. 2021. Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses. Nature Communications. 12(1), 2912.","apa":"Vandael, D. H., Okamoto, Y., &#38; Jonas, P. M. (2021). Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses. <i>Nature Communications</i>. Springer. <a href=\"https://doi.org/10.1038/s41467-021-23153-5\">https://doi.org/10.1038/s41467-021-23153-5</a>","short":"D.H. Vandael, Y. Okamoto, P.M. Jonas, Nature Communications 12 (2021).","ama":"Vandael DH, Okamoto Y, Jonas PM. Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-23153-5\">10.1038/s41467-021-23153-5</a>","chicago":"Vandael, David H, Yuji Okamoto, and Peter M Jonas. “Transsynaptic Modulation of Presynaptic Short-Term Plasticity in Hippocampal Mossy Fiber Synapses.” <i>Nature Communications</i>. Springer, 2021. <a href=\"https://doi.org/10.1038/s41467-021-23153-5\">https://doi.org/10.1038/s41467-021-23153-5</a>."},"department":[{"_id":"PeJo"}],"project":[{"call_identifier":"H2020","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","grant_number":"692692"},{"grant_number":"Z00312","_id":"25C5A090-B435-11E9-9278-68D0E5697425","name":"Synaptic communication in neuronal microcircuits","call_identifier":"FWF"}],"file_date_updated":"2021-12-17T11:34:50Z","volume":12,"oa":1,"_id":"9778","oa_version":"Published Version","author":[{"last_name":"Vandael","first_name":"David H","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7577-1676","full_name":"Vandael, David H"},{"last_name":"Okamoto","full_name":"Okamoto, Yuji","orcid":"0000-0003-0408-6094","id":"3337E116-F248-11E8-B48F-1D18A9856A87","first_name":"Yuji"},{"first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","last_name":"Jonas"}],"publication_status":"published","type":"journal_article","OA_place":"publisher","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/synaptic-transmission-not-a-one-way-street/","description":"News on IST Homepage"}]},"article_number":"2912","article_processing_charge":"Yes","quality_controlled":"1","pmid":1,"has_accepted_license":"1","issue":"1","acknowledgement":"We thank Drs. Carolina Borges-Merjane and Jose Guzman for critically reading the manuscript, and Pablo Castillo for discussions. We are grateful to Alois Schlögl for help with analysis, Florian Marr for excellent technical assistance and cell reconstruction, Christina Altmutter for technical help, Eleftheria Kralli-Beller for manuscript editing, and the Scientific Service Units of IST Austria for support. This project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 692692) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award), both to P.J.","status":"public","isi":1,"intvolume":"        12","doi":"10.1038/s41467-021-23153-5"},{"date_created":"2021-09-02T11:49:47Z","date_updated":"2025-05-14T10:51:45Z","publication":"SciPost Physics","ddc":["519"],"ec_funded":1,"month":"09","date_published":"2021-09-02T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","year":"2021","scopus_import":"1","day":"02","title":"Importance sampling scheme for the stochastic simulation of quantum spin dynamics","language":[{"iso":"eng"}],"abstract":[{"text":"The numerical simulation of dynamical phenomena in interacting quantum systems is a notoriously hard problem. Although a number of promising numerical methods exist, they often have limited applicability due to the growth of entanglement or the presence of the so-called sign problem. In this work, we develop an importance sampling scheme for the simulation of quantum spin dynamics, building on a recent approach mapping quantum spin systems to classical stochastic processes. The importance sampling scheme is based on identifying the classical trajectory that yields the largest contribution to a given quantum observable. An exact transformation is then carried out to preferentially sample trajectories that are close to the dominant one. We demonstrate that this approach is capable of reducing the temporal growth of fluctuations in the stochastic quantities, thus extending the range of accessible times and system sizes compared to direct sampling. We discuss advantages and limitations of the proposed approach, outlining directions\r\nfor further developments.","lang":"eng"}],"publication_identifier":{"eissn":["2666-9366"],"issn":["2542-4653"]},"file":[{"checksum":"e4ec69d893e31811efc6093cb6ea8eb7","creator":"cchlebak","file_name":"2021_SciPostPhys_DeNicola.pdf","content_type":"application/pdf","success":1,"file_id":"9984","date_updated":"2021-09-02T14:05:43Z","file_size":373833,"relation":"main_file","date_created":"2021-09-02T14:05:43Z","access_level":"open_access"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"keyword":["General Physics and Astronomy"],"quality_controlled":"1","article_processing_charge":"No","article_number":"048","type":"journal_article","author":[{"last_name":"De Nicola","orcid":"0000-0002-4842-6671","full_name":"De Nicola, Stefano","id":"42832B76-F248-11E8-B48F-1D18A9856A87","first_name":"Stefano"}],"publication_status":"published","intvolume":"        11","doi":"10.21468/scipostphys.11.3.048","isi":1,"status":"public","has_accepted_license":"1","issue":"3","arxiv":1,"publisher":"SciPost Foundation","external_id":{"isi":["000692534200001"],"arxiv":["2103.16468"]},"_id":"9981","oa_version":"Published Version","oa":1,"file_date_updated":"2021-09-02T14:05:43Z","volume":11,"citation":{"ieee":"S. De Nicola, “Importance sampling scheme for the stochastic simulation of quantum spin dynamics,” <i>SciPost Physics</i>, vol. 11, no. 3. SciPost Foundation, 2021.","ista":"De Nicola S. 2021. Importance sampling scheme for the stochastic simulation of quantum spin dynamics. SciPost Physics. 11(3), 048.","mla":"De Nicola, Stefano. “Importance Sampling Scheme for the Stochastic Simulation of Quantum Spin Dynamics.” <i>SciPost Physics</i>, vol. 11, no. 3, 048, SciPost Foundation, 2021, doi:<a href=\"https://doi.org/10.21468/scipostphys.11.3.048\">10.21468/scipostphys.11.3.048</a>.","apa":"De Nicola, S. (2021). Importance sampling scheme for the stochastic simulation of quantum spin dynamics. <i>SciPost Physics</i>. SciPost Foundation. <a href=\"https://doi.org/10.21468/scipostphys.11.3.048\">https://doi.org/10.21468/scipostphys.11.3.048</a>","short":"S. De Nicola, SciPost Physics 11 (2021).","ama":"De Nicola S. Importance sampling scheme for the stochastic simulation of quantum spin dynamics. <i>SciPost Physics</i>. 2021;11(3). doi:<a href=\"https://doi.org/10.21468/scipostphys.11.3.048\">10.21468/scipostphys.11.3.048</a>","chicago":"De Nicola, Stefano. “Importance Sampling Scheme for the Stochastic Simulation of Quantum Spin Dynamics.” <i>SciPost Physics</i>. SciPost Foundation, 2021. <a href=\"https://doi.org/10.21468/scipostphys.11.3.048\">https://doi.org/10.21468/scipostphys.11.3.048</a>."},"department":[{"_id":"MaSe"}],"project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}]},{"publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"abstract":[{"text":"Attosecond chronoscopy has revealed small but measurable delays in photoionization, characterized by the ejection of an electron on absorption of a single photon. Ionization-delay measurements in atomic targets provide a wealth of information about the timing of the photoelectric effect, resonances, electron correlations and transport. However, extending this approach to molecules presents challenges, such as identifying the correct ionization channels and the effect of the anisotropic molecular landscape on the measured delays. Here, we measure ionization delays from ethyl iodide around a giant dipole resonance. By using the theoretical value for the iodine atom as a reference, we disentangle the contribution from the functional ethyl group, which is responsible for the characteristic chemical reactivity of a molecule. We find a substantial additional delay caused by the presence of a functional group, which encodes the effect of the molecular potential on the departing electron. Such information is inaccessible to the conventional approach of measuring photoionization cross-sections. The results establish ionization-delay measurements as a valuable tool in investigating the electronic properties of molecules.","lang":"eng"}],"language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy"],"date_published":"2020-07-01T00:00:00Z","month":"07","page":"778-783","date_created":"2023-08-09T13:10:07Z","date_updated":"2023-08-22T07:38:04Z","publication":"Nature Physics","title":"Probing molecular environment through photoemission delays","day":"01","article_type":"original","year":"2020","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature","citation":{"ieee":"S. Biswas <i>et al.</i>, “Probing molecular environment through photoemission delays,” <i>Nature Physics</i>, vol. 16, no. 7. Springer Nature, pp. 778–783, 2020.","mla":"Biswas, Shubhadeep, et al. “Probing Molecular Environment through Photoemission Delays.” <i>Nature Physics</i>, vol. 16, no. 7, Springer Nature, 2020, pp. 778–83, doi:<a href=\"https://doi.org/10.1038/s41567-020-0887-8\">10.1038/s41567-020-0887-8</a>.","ista":"Biswas S, Förg B, Ortmann L, Schötz J, Schweinberger W, Zimmermann T, Pi L, Baykusheva DR, Masood HA, Liontos I, Kamal AM, Kling NG, Alharbi AF, Alharbi M, Azzeer AM, Hartmann G, Wörner HJ, Landsman AS, Kling MF. 2020. Probing molecular environment through photoemission delays. Nature Physics. 16(7), 778–783.","apa":"Biswas, S., Förg, B., Ortmann, L., Schötz, J., Schweinberger, W., Zimmermann, T., … Kling, M. F. (2020). Probing molecular environment through photoemission delays. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-020-0887-8\">https://doi.org/10.1038/s41567-020-0887-8</a>","short":"S. Biswas, B. Förg, L. Ortmann, J. Schötz, W. Schweinberger, T. Zimmermann, L. Pi, D.R. Baykusheva, H.A. Masood, I. Liontos, A.M. Kamal, N.G. Kling, A.F. Alharbi, M. Alharbi, A.M. Azzeer, G. Hartmann, H.J. Wörner, A.S. Landsman, M.F. Kling, Nature Physics 16 (2020) 778–783.","ama":"Biswas S, Förg B, Ortmann L, et al. Probing molecular environment through photoemission delays. <i>Nature Physics</i>. 2020;16(7):778-783. doi:<a href=\"https://doi.org/10.1038/s41567-020-0887-8\">10.1038/s41567-020-0887-8</a>","chicago":"Biswas, Shubhadeep, Benjamin Förg, Lisa Ortmann, Johannes Schötz, Wolfgang Schweinberger, Tomáš Zimmermann, Liangwen Pi, et al. “Probing Molecular Environment through Photoemission Delays.” <i>Nature Physics</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41567-020-0887-8\">https://doi.org/10.1038/s41567-020-0887-8</a>."},"volume":16,"oa_version":"None","_id":"13999","author":[{"last_name":"Biswas","full_name":"Biswas, Shubhadeep","first_name":"Shubhadeep"},{"first_name":"Benjamin","full_name":"Förg, Benjamin","last_name":"Förg"},{"last_name":"Ortmann","first_name":"Lisa","full_name":"Ortmann, Lisa"},{"last_name":"Schötz","full_name":"Schötz, Johannes","first_name":"Johannes"},{"first_name":"Wolfgang","full_name":"Schweinberger, Wolfgang","last_name":"Schweinberger"},{"last_name":"Zimmermann","first_name":"Tomáš","full_name":"Zimmermann, Tomáš"},{"first_name":"Liangwen","full_name":"Pi, Liangwen","last_name":"Pi"},{"last_name":"Baykusheva","first_name":"Denitsa Rangelova","id":"71b4d059-2a03-11ee-914d-dfa3beed6530","full_name":"Baykusheva, Denitsa Rangelova"},{"first_name":"Hafiz A.","full_name":"Masood, Hafiz A.","last_name":"Masood"},{"last_name":"Liontos","first_name":"Ioannis","full_name":"Liontos, Ioannis"},{"full_name":"Kamal, Amgad M.","first_name":"Amgad M.","last_name":"Kamal"},{"last_name":"Kling","full_name":"Kling, Nora G.","first_name":"Nora G."},{"last_name":"Alharbi","first_name":"Abdullah F.","full_name":"Alharbi, Abdullah F."},{"first_name":"Meshaal","full_name":"Alharbi, Meshaal","last_name":"Alharbi"},{"full_name":"Azzeer, Abdallah M.","first_name":"Abdallah M.","last_name":"Azzeer"},{"last_name":"Hartmann","first_name":"Gregor","full_name":"Hartmann, Gregor"},{"last_name":"Wörner","full_name":"Wörner, Hans J.","first_name":"Hans J."},{"last_name":"Landsman","first_name":"Alexandra S.","full_name":"Landsman, Alexandra S."},{"last_name":"Kling","first_name":"Matthias F.","full_name":"Kling, Matthias F."}],"publication_status":"published","extern":"1","type":"journal_article","quality_controlled":"1","article_processing_charge":"No","issue":"7","status":"public","intvolume":"        16","doi":"10.1038/s41567-020-0887-8"},{"author":[{"last_name":"O’Brien","first_name":"Roisin E.","full_name":"O’Brien, Roisin E."},{"last_name":"Santos","first_name":"Inês C.","full_name":"Santos, Inês C."},{"first_name":"Daniel","full_name":"Wrapp, Daniel","last_name":"Wrapp"},{"orcid":"0000-0003-0456-0753","full_name":"Bravo, Jack Peter Kelly","first_name":"Jack Peter Kelly","id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","last_name":"Bravo"},{"first_name":"Evan A.","full_name":"Schwartz, Evan A.","last_name":"Schwartz"},{"full_name":"Brodbelt, Jennifer S.","first_name":"Jennifer S.","last_name":"Brodbelt"},{"last_name":"Taylor","full_name":"Taylor, David W.","first_name":"David W."}],"publication_status":"published","extern":"1","type":"journal_article","article_number":"5931","article_processing_charge":"Yes","quality_controlled":"1","pmid":1,"status":"public","intvolume":"        11","doi":"10.1038/s41467-020-19785-8","publisher":"Springer Nature","external_id":{"pmid":["33230133"]},"citation":{"chicago":"O’Brien, Roisin E., Inês C. Santos, Daniel Wrapp, Jack Peter Kelly Bravo, Evan A. Schwartz, Jennifer S. Brodbelt, and David W. Taylor. “Structural Basis for Assembly of Non-Canonical Small Subunits into Type I-C Cascade.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-19785-8\">https://doi.org/10.1038/s41467-020-19785-8</a>.","short":"R.E. O’Brien, I.C. Santos, D. Wrapp, J.P.K. Bravo, E.A. Schwartz, J.S. Brodbelt, D.W. Taylor, Nature Communications 11 (2020).","ama":"O’Brien RE, Santos IC, Wrapp D, et al. Structural basis for assembly of non-canonical small subunits into type I-C Cascade. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-19785-8\">10.1038/s41467-020-19785-8</a>","apa":"O’Brien, R. E., Santos, I. C., Wrapp, D., Bravo, J. P. K., Schwartz, E. A., Brodbelt, J. S., &#38; Taylor, D. W. (2020). Structural basis for assembly of non-canonical small subunits into type I-C Cascade. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-19785-8\">https://doi.org/10.1038/s41467-020-19785-8</a>","ista":"O’Brien RE, Santos IC, Wrapp D, Bravo JPK, Schwartz EA, Brodbelt JS, Taylor DW. 2020. Structural basis for assembly of non-canonical small subunits into type I-C Cascade. Nature Communications. 11, 5931.","mla":"O’Brien, Roisin E., et al. “Structural Basis for Assembly of Non-Canonical Small Subunits into Type I-C Cascade.” <i>Nature Communications</i>, vol. 11, 5931, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-19785-8\">10.1038/s41467-020-19785-8</a>.","ieee":"R. E. O’Brien <i>et al.</i>, “Structural basis for assembly of non-canonical small subunits into type I-C Cascade,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020."},"volume":11,"oa_version":"Published Version","_id":"15142","oa":1,"date_published":"2020-11-23T00:00:00Z","month":"11","date_created":"2024-03-20T10:43:07Z","publication":"Nature Communications","date_updated":"2024-06-04T05:52:51Z","title":"Structural basis for assembly of non-canonical small subunits into type I-C Cascade","day":"23","article_type":"original","scopus_import":"1","year":"2020","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://doi.org/10.1038/s41467-020-19785-8","open_access":"1"}],"abstract":[{"lang":"eng","text":"Bacteria and archaea employ CRISPR (clustered, regularly, interspaced, short palindromic repeats)-Cas (CRISPR-associated) systems as a type of adaptive immunity to target and degrade foreign nucleic acids. While a myriad of CRISPR-Cas systems have been identified to date, type I-C is one of the most commonly found subtypes in nature. Interestingly, the type I-C system employs a minimal Cascade effector complex, which encodes only three unique subunits in its operon. Here, we present a 3.1 Å resolution cryo-EM structure of the <jats:italic>Desulfovibrio vulgaris</jats:italic> type I-C Cascade, revealing the molecular mechanisms that underlie RNA-directed complex assembly. We demonstrate how this minimal Cascade utilizes previously overlooked, non-canonical small subunits to stabilize R-loop formation. Furthermore, we describe putative PAM and Cas3 binding sites. These findings provide the structural basis for harnessing the type I-C Cascade as a genome-engineering tool."}],"publication_identifier":{"issn":["2041-1723"]},"language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"]},{"intvolume":"       124","doi":"10.1103/physrevlett.124.048102","issue":"4","status":"public","acknowledgement":"We thank Samantha Miller, Bert Poolman, and the members of Šarić and Pilizota laboratories for useful discussion. We acknowledge support from the Engineering and Physical Sciences Research Council (A.P. and A.Š.), the UCL Institute for the Physics of Living Systems (A.P. and A.Š.), Darwin Trust of University of Edinburgh (H.S.), Industrial Biotechnology Innovation Centre (H.S. and T.P.), BBSRC Council Crossing Biological Membrane Network (H.S. and T.P.), BBSRC/EPSRC/MRC Synthetic Biology Research Centre (T.P.), and the Royal Society (A.Š.).","article_number":"048102","article_processing_charge":"No","quality_controlled":"1","pmid":1,"author":[{"last_name":"Paraschiv","first_name":"Alexandru","full_name":"Paraschiv, Alexandru"},{"full_name":"Hegde, Smitha","first_name":"Smitha","last_name":"Hegde"},{"last_name":"Ganti","first_name":"Raman","full_name":"Ganti, Raman"},{"first_name":"Teuta","full_name":"Pilizota, Teuta","last_name":"Pilizota"},{"full_name":"Šarić, Anđela","orcid":"0000-0002-7854-2139","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","first_name":"Anđela","last_name":"Šarić"}],"publication_status":"published","extern":"1","type":"journal_article","volume":124,"_id":"10353","oa_version":"Preprint","oa":1,"citation":{"chicago":"Paraschiv, Alexandru, Smitha Hegde, Raman Ganti, Teuta Pilizota, and Anđela Šarić. “Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels.” <i>Physical Review Letters</i>. American Physical Society, 2020. <a href=\"https://doi.org/10.1103/physrevlett.124.048102\">https://doi.org/10.1103/physrevlett.124.048102</a>.","ama":"Paraschiv A, Hegde S, Ganti R, Pilizota T, Šarić A. Dynamic clustering regulates activity of mechanosensitive membrane channels. <i>Physical Review Letters</i>. 2020;124(4). doi:<a href=\"https://doi.org/10.1103/physrevlett.124.048102\">10.1103/physrevlett.124.048102</a>","apa":"Paraschiv, A., Hegde, S., Ganti, R., Pilizota, T., &#38; Šarić, A. (2020). Dynamic clustering regulates activity of mechanosensitive membrane channels. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevlett.124.048102\">https://doi.org/10.1103/physrevlett.124.048102</a>","short":"A. Paraschiv, S. Hegde, R. Ganti, T. Pilizota, A. Šarić, Physical Review Letters 124 (2020).","mla":"Paraschiv, Alexandru, et al. “Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels.” <i>Physical Review Letters</i>, vol. 124, no. 4, 048102, American Physical Society, 2020, doi:<a href=\"https://doi.org/10.1103/physrevlett.124.048102\">10.1103/physrevlett.124.048102</a>.","ista":"Paraschiv A, Hegde S, Ganti R, Pilizota T, Šarić A. 2020. Dynamic clustering regulates activity of mechanosensitive membrane channels. Physical Review Letters. 124(4), 048102.","ieee":"A. Paraschiv, S. Hegde, R. Ganti, T. Pilizota, and A. Šarić, “Dynamic clustering regulates activity of mechanosensitive membrane channels,” <i>Physical Review Letters</i>, vol. 124, no. 4. American Physical Society, 2020."},"publisher":"American Physical Society","external_id":{"pmid":["32058787"]},"article_type":"original","scopus_import":"1","year":"2020","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","title":"Dynamic clustering regulates activity of mechanosensitive membrane channels","day":"31","date_created":"2021-11-26T09:57:01Z","publication":"Physical Review Letters","date_updated":"2021-11-26T11:21:12Z","date_published":"2020-01-31T00:00:00Z","month":"01","keyword":["general physics and astronomy"],"language":[{"iso":"eng"}],"main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/553248","open_access":"1"}],"publication_identifier":{"eissn":["1079-7114"],"issn":["0031-9007"]},"abstract":[{"lang":"eng","text":"Experiments have suggested that bacterial mechanosensitive channels separate into 2D clusters, the role of which is unclear. By developing a coarse-grained computer model we find that clustering promotes the channel closure, which is highly dependent on the channel concentration and membrane stress. This behaviour yields a tightly regulated gating system, whereby at high tensions channels gate individually, and at lower tensions the channels spontaneously aggregate and inactivate. We implement this positive feedback into the model for cell volume regulation, and find that the channel clustering protects the cell against excessive loss of cytoplasmic content."}]},{"date_created":"2020-09-25T07:23:13Z","date_updated":"2025-06-12T06:58:51Z","publication":"Nature Communications","ddc":["530"],"month":"09","date_published":"2020-09-24T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","year":"2020","scopus_import":"1","day":"24","title":"Persistent and reversible solid iodine electrodeposition in nanoporous carbons","corr_author":"1","language":[{"iso":"eng"}],"publication_identifier":{"issn":["2041-1723"]},"abstract":[{"lang":"eng","text":"Aqueous iodine based electrochemical energy storage is considered a potential candidate to improve sustainability and performance of current battery and supercapacitor technology. It harnesses the redox activity of iodide, iodine, and polyiodide species in the confined geometry of nanoporous carbon electrodes. However, current descriptions of the electrochemical reaction mechanism to interconvert these species are elusive. Here we show that electrochemical oxidation of iodide in nanoporous carbons forms persistent solid iodine deposits. Confinement slows down dissolution into triiodide and pentaiodide, responsible for otherwise significant self-discharge via shuttling. The main tools for these insights are in situ Raman spectroscopy and in situ small and wide-angle X-ray scattering (in situ SAXS/WAXS). In situ Raman confirms the reversible formation of triiodide and pentaiodide. In situ SAXS/WAXS indicates remarkable amounts of solid iodine deposited in the carbon nanopores. Combined with stochastic modeling, in situ SAXS allows quantifying the solid iodine volume fraction and visualizing the iodine structure on 3D lattice models at the sub-nanometer scale. Based on the derived mechanism, we demonstrate strategies for improved iodine pore filling capacity and prevention of self-discharge, applicable to hybrid supercapacitors and batteries."}],"file":[{"creator":"dernst","checksum":"eada7bc8dd16a49390137cff882ef328","file_name":"2020_NatureComm_Prehal.pdf","success":1,"file_id":"8585","content_type":"application/pdf","access_level":"open_access","date_created":"2020-09-28T13:16:15Z","file_size":1822469,"relation":"main_file","date_updated":"2020-09-28T13:16:15Z"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"article_processing_charge":"No","quality_controlled":"1","pmid":1,"related_material":{"link":[{"url":"https://doi.org/10.1038/s41467-020-19720-x","relation":"erratum"}]},"article_number":"4838","type":"journal_article","author":[{"last_name":"Prehal","first_name":"Christian","full_name":"Prehal, Christian"},{"last_name":"Fitzek","full_name":"Fitzek, Harald","first_name":"Harald"},{"last_name":"Kothleitner","full_name":"Kothleitner, Gerald","first_name":"Gerald"},{"first_name":"Volker","full_name":"Presser, Volker","last_name":"Presser"},{"last_name":"Gollas","first_name":"Bernhard","full_name":"Gollas, Bernhard"},{"first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319","last_name":"Freunberger"},{"first_name":"Qamar","full_name":"Abbas, Qamar","last_name":"Abbas"}],"publication_status":"published","intvolume":"        11","doi":"10.1038/s41467-020-18610-6","isi":1,"status":"public","has_accepted_license":"1","publisher":"Springer Nature","external_id":{"pmid":["32973214"],"isi":["000573756600004"]},"oa_version":"Published Version","_id":"8568","oa":1,"file_date_updated":"2020-09-28T13:16:15Z","volume":11,"department":[{"_id":"StFr"}],"citation":{"ieee":"C. Prehal <i>et al.</i>, “Persistent and reversible solid iodine electrodeposition in nanoporous carbons,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","mla":"Prehal, Christian, et al. “Persistent and Reversible Solid Iodine Electrodeposition in Nanoporous Carbons.” <i>Nature Communications</i>, vol. 11, 4838, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-18610-6\">10.1038/s41467-020-18610-6</a>.","ista":"Prehal C, Fitzek H, Kothleitner G, Presser V, Gollas B, Freunberger SA, Abbas Q. 2020. Persistent and reversible solid iodine electrodeposition in nanoporous carbons. Nature Communications. 11, 4838.","apa":"Prehal, C., Fitzek, H., Kothleitner, G., Presser, V., Gollas, B., Freunberger, S. A., &#38; Abbas, Q. (2020). Persistent and reversible solid iodine electrodeposition in nanoporous carbons. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-18610-6\">https://doi.org/10.1038/s41467-020-18610-6</a>","short":"C. Prehal, H. Fitzek, G. Kothleitner, V. Presser, B. Gollas, S.A. Freunberger, Q. Abbas, Nature Communications 11 (2020).","ama":"Prehal C, Fitzek H, Kothleitner G, et al. Persistent and reversible solid iodine electrodeposition in nanoporous carbons. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-18610-6\">10.1038/s41467-020-18610-6</a>","chicago":"Prehal, Christian, Harald Fitzek, Gerald Kothleitner, Volker Presser, Bernhard Gollas, Stefan Alexander Freunberger, and Qamar Abbas. “Persistent and Reversible Solid Iodine Electrodeposition in Nanoporous Carbons.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-18610-6\">https://doi.org/10.1038/s41467-020-18610-6</a>."}},{"keyword":["General Engineering","General Physics and Astronomy","General Materials Science","Medicine (miscellaneous)","General Chemical Engineering","Biochemistry","Genetics and Molecular Biology (miscellaneous)"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"language":[{"iso":"eng"}],"file":[{"file_id":"8938","success":1,"content_type":"application/pdf","file_name":"2020_AdvScience_Tian.pdf","creator":"dernst","checksum":"92818c23ecc70e35acfa671f3cfb9909","date_created":"2020-12-10T14:07:24Z","access_level":"open_access","date_updated":"2020-12-10T14:07:24Z","file_size":7835833,"relation":"main_file"}],"publication_identifier":{"issn":["2198-3844"]},"abstract":[{"lang":"eng","text":"Glioblastoma is the most malignant cancer in the brain and currently incurable. It is urgent to identify effective targets for this lethal disease. Inhibition of such targets should suppress the growth of cancer cells and, ideally also precancerous cells for early prevention, but minimally affect their normal counterparts. Using genetic mouse models with neural stem cells (NSCs) or oligodendrocyte precursor cells (OPCs) as the cells‐of‐origin/mutation, it is shown that the susceptibility of cells within the development hierarchy of glioma to the knockout of insulin‐like growth factor I receptor (IGF1R) is determined not only by their oncogenic states, but also by their cell identities/states. Knockout of IGF1R selectively disrupts the growth of mutant and transformed, but not normal OPCs, or NSCs. The desirable outcome of IGF1R knockout on cell growth requires the mutant cells to commit to the OPC identity regardless of its development hierarchical status. At the molecular level, oncogenic mutations reprogram the cellular network of OPCs and force them to depend more on IGF1R for their growth. A new‐generation brain‐penetrable, orally available IGF1R inhibitor harnessing tumor OPCs in the brain is also developed. The findings reveal the cellular window of IGF1R targeting and establish IGF1R as an effective target for the prevention and treatment of glioblastoma."}],"scopus_import":"1","article_type":"original","year":"2020","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting","day":"04","ddc":["570"],"publication":"Advanced Science","date_updated":"2025-06-12T06:59:38Z","date_created":"2020-10-01T09:44:13Z","date_published":"2020-11-04T00:00:00Z","month":"11","ec_funded":1,"file_date_updated":"2020-12-10T14:07:24Z","volume":7,"_id":"8592","oa":1,"oa_version":"Published Version","project":[{"name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","call_identifier":"H2020","_id":"260018B0-B435-11E9-9278-68D0E5697425","grant_number":"725780"}],"citation":{"ieee":"A. Tian <i>et al.</i>, “Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting,” <i>Advanced Science</i>, vol. 7, no. 21. Wiley, 2020.","mla":"Tian, Anhao, et al. “Oncogenic State and Cell Identity Combinatorially Dictate the Susceptibility of Cells within Glioma Development Hierarchy to IGF1R Targeting.” <i>Advanced Science</i>, vol. 7, no. 21, 2001724, Wiley, 2020, doi:<a href=\"https://doi.org/10.1002/advs.202001724\">10.1002/advs.202001724</a>.","ista":"Tian A, Kang B, Li B, Qiu B, Jiang W, Shao F, Gao Q, Liu R, Cai C, Jing R, Wang W, Chen P, Liang Q, Bao L, Man J, Wang Y, Shi Y, Li J, Yang M, Wang L, Zhang J, Hippenmeyer S, Zhu J, Bian X, Wang Y, Liu C. 2020. Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting. Advanced Science. 7(21), 2001724.","apa":"Tian, A., Kang, B., Li, B., Qiu, B., Jiang, W., Shao, F., … Liu, C. (2020). Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting. <i>Advanced Science</i>. Wiley. <a href=\"https://doi.org/10.1002/advs.202001724\">https://doi.org/10.1002/advs.202001724</a>","short":"A. Tian, B. Kang, B. Li, B. Qiu, W. Jiang, F. Shao, Q. Gao, R. Liu, C. Cai, R. Jing, W. Wang, P. Chen, Q. Liang, L. Bao, J. Man, Y. Wang, Y. Shi, J. Li, M. Yang, L. Wang, J. Zhang, S. Hippenmeyer, J. Zhu, X. Bian, Y. Wang, C. Liu, Advanced Science 7 (2020).","ama":"Tian A, Kang B, Li B, et al. Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting. <i>Advanced Science</i>. 2020;7(21). doi:<a href=\"https://doi.org/10.1002/advs.202001724\">10.1002/advs.202001724</a>","chicago":"Tian, Anhao, Bo Kang, Baizhou Li, Biying Qiu, Wenhong Jiang, Fangjie Shao, Qingqing Gao, et al. “Oncogenic State and Cell Identity Combinatorially Dictate the Susceptibility of Cells within Glioma Development Hierarchy to IGF1R Targeting.” <i>Advanced Science</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/advs.202001724\">https://doi.org/10.1002/advs.202001724</a>."},"department":[{"_id":"SiHi"}],"external_id":{"isi":["000573860700001"],"pmid":["33173731"]},"publisher":"Wiley","isi":1,"doi":"10.1002/advs.202001724","intvolume":"         7","issue":"21","status":"public","acknowledgement":"The authors thank Drs. J. Eisen, QR. Lu, S. Duan, Z‐H. Li, W. Mo, and Q. Wu for their critical comments on the manuscript. They also thank Dr. H. Zong for providing the CKO_NG2‐CreER model. This work is supported by the National Key Research and Development Program of China, Stem Cell and Translational Research (2016YFA0101201 to C.L., 2016YFA0100303 to Y.J.W.), the National Natural Science Foundation of China (81673035 and 81972915 to C.L., 81472722 to Y.J.W.), the Science Foundation for Distinguished Young Scientists of Zhejiang Province (LR17H160001 to C.L.), Fundamental Research Funds for the Central Universities (2016QNA7023 and 2017QNA7028 to C.L.) and the Thousand Talent Program for Young Outstanding Scientists, China (to C.L.), IST Austria institutional funds (to S.H.), European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (725780 LinPro to S.H.). C.L. is a scholar of K. C. Wong Education Foundation.","has_accepted_license":"1","article_number":"2001724","pmid":1,"quality_controlled":"1","article_processing_charge":"No","author":[{"last_name":"Tian","first_name":"Anhao","full_name":"Tian, Anhao"},{"last_name":"Kang","full_name":"Kang, Bo","first_name":"Bo"},{"last_name":"Li","full_name":"Li, Baizhou","first_name":"Baizhou"},{"first_name":"Biying","full_name":"Qiu, Biying","last_name":"Qiu"},{"last_name":"Jiang","full_name":"Jiang, Wenhong","first_name":"Wenhong"},{"full_name":"Shao, Fangjie","first_name":"Fangjie","last_name":"Shao"},{"first_name":"Qingqing","full_name":"Gao, Qingqing","last_name":"Gao"},{"last_name":"Liu","first_name":"Rui","full_name":"Liu, Rui"},{"full_name":"Cai, Chengwei","first_name":"Chengwei","last_name":"Cai"},{"full_name":"Jing, Rui","first_name":"Rui","last_name":"Jing"},{"first_name":"Wei","full_name":"Wang, Wei","last_name":"Wang"},{"full_name":"Chen, Pengxiang","first_name":"Pengxiang","last_name":"Chen"},{"last_name":"Liang","full_name":"Liang, Qinghui","first_name":"Qinghui"},{"last_name":"Bao","first_name":"Lili","full_name":"Bao, Lili"},{"first_name":"Jianghong","full_name":"Man, Jianghong","last_name":"Man"},{"full_name":"Wang, Yan","first_name":"Yan","last_name":"Wang"},{"first_name":"Yu","full_name":"Shi, Yu","last_name":"Shi"},{"last_name":"Li","full_name":"Li, Jin","first_name":"Jin"},{"last_name":"Yang","first_name":"Minmin","full_name":"Yang, Minmin"},{"full_name":"Wang, Lisha","first_name":"Lisha","last_name":"Wang"},{"full_name":"Zhang, Jianmin","first_name":"Jianmin","last_name":"Zhang"},{"last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon"},{"last_name":"Zhu","full_name":"Zhu, Junming","first_name":"Junming"},{"full_name":"Bian, Xiuwu","first_name":"Xiuwu","last_name":"Bian"},{"first_name":"Ying‐Jie","full_name":"Wang, Ying‐Jie","last_name":"Wang"},{"full_name":"Liu, Chong","first_name":"Chong","last_name":"Liu"}],"publication_status":"published","type":"journal_article"},{"language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2008.02367"}],"abstract":[{"lang":"eng","text":"In laboratory studies and numerical simulations, we observe clear signatures of unstable time-periodic solutions in a moderately turbulent quasi-two-dimensional flow. We validate the dynamical relevance of such solutions by demonstrating that turbulent flows in both experiment and numerics transiently display time-periodic dynamics when they shadow unstable periodic orbits (UPOs). We show that UPOs we computed are also statistically significant, with turbulent flows spending a sizable fraction of the total time near these solutions. As a result, the average rates of energy input and dissipation for the turbulent flow and frequently visited UPOs differ only by a few percent."}],"publication_identifier":{"issn":["0031-9007"],"eissn":["1079-7114"]},"keyword":["General Physics and Astronomy"],"date_created":"2020-10-08T17:27:32Z","date_updated":"2025-04-15T06:50:02Z","publication":"Physical Review Letters","date_published":"2020-08-05T00:00:00Z","ec_funded":1,"month":"08","scopus_import":"1","article_type":"original","year":"2020","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","title":"Capturing turbulent dynamics and statistics in experiments with unstable periodic orbits","day":"05","arxiv":1,"publisher":"American Physical Society","external_id":{"arxiv":["2008.02367"],"isi":["000555785600005"]},"volume":125,"_id":"8634","oa_version":"Preprint","oa":1,"department":[{"_id":"BjHo"}],"citation":{"apa":"Suri, B., Kageorge, L., Grigoriev, R. O., &#38; Schatz, M. F. (2020). Capturing turbulent dynamics and statistics in experiments with unstable periodic orbits. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevlett.125.064501\">https://doi.org/10.1103/physrevlett.125.064501</a>","ama":"Suri B, Kageorge L, Grigoriev RO, Schatz MF. Capturing turbulent dynamics and statistics in experiments with unstable periodic orbits. <i>Physical Review Letters</i>. 2020;125(6). doi:<a href=\"https://doi.org/10.1103/physrevlett.125.064501\">10.1103/physrevlett.125.064501</a>","short":"B. Suri, L. Kageorge, R.O. Grigoriev, M.F. Schatz, Physical Review Letters 125 (2020).","chicago":"Suri, Balachandra, Logan Kageorge, Roman O. Grigoriev, and Michael F. Schatz. “Capturing Turbulent Dynamics and Statistics in Experiments with Unstable Periodic Orbits.” <i>Physical Review Letters</i>. American Physical Society, 2020. <a href=\"https://doi.org/10.1103/physrevlett.125.064501\">https://doi.org/10.1103/physrevlett.125.064501</a>.","ieee":"B. Suri, L. Kageorge, R. O. Grigoriev, and M. F. Schatz, “Capturing turbulent dynamics and statistics in experiments with unstable periodic orbits,” <i>Physical Review Letters</i>, vol. 125, no. 6. American Physical Society, 2020.","ista":"Suri B, Kageorge L, Grigoriev RO, Schatz MF. 2020. Capturing turbulent dynamics and statistics in experiments with unstable periodic orbits. Physical Review Letters. 125(6), 064501.","mla":"Suri, Balachandra, et al. “Capturing Turbulent Dynamics and Statistics in Experiments with Unstable Periodic Orbits.” <i>Physical Review Letters</i>, vol. 125, no. 6, 064501, American Physical Society, 2020, doi:<a href=\"https://doi.org/10.1103/physrevlett.125.064501\">10.1103/physrevlett.125.064501</a>."},"project":[{"grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7"}],"article_number":"064501","article_processing_charge":"No","quality_controlled":"1","publication_status":"published","author":[{"full_name":"Suri, Balachandra","id":"47A5E706-F248-11E8-B48F-1D18A9856A87","first_name":"Balachandra","last_name":"Suri"},{"last_name":"Kageorge","full_name":"Kageorge, Logan","first_name":"Logan"},{"full_name":"Grigoriev, Roman O.","first_name":"Roman O.","last_name":"Grigoriev"},{"last_name":"Schatz","first_name":"Michael F.","full_name":"Schatz, Michael F."}],"type":"journal_article","isi":1,"intvolume":"       125","doi":"10.1103/physrevlett.125.064501","status":"public","acknowledgement":"M. F. S. and R. O. G. acknowledge funding from the National Science Foundation (CMMI-1234436, DMS1125302, CMMI-1725587) and Defense Advanced Research Projects Agency (HR0011-16-2-0033). B. S.has received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/2007–2013/ under REA Grant Agreement No. 291734.","issue":"6"},{"citation":{"chicago":"Schulte, Linda, Jiafei Mao, Julian Reitz, Sridhar Sreeramulu, Denis Kudlinzki, Victor-Valentin Hodirnau, Jakob Meier-Credo, et al. “Cysteine Oxidation and Disulfide Formation in the Ribosomal Exit Tunnel.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-19372-x\">https://doi.org/10.1038/s41467-020-19372-x</a>.","apa":"Schulte, L., Mao, J., Reitz, J., Sreeramulu, S., Kudlinzki, D., Hodirnau, V.-V., … Schwalbe, H. (2020). Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-19372-x\">https://doi.org/10.1038/s41467-020-19372-x</a>","short":"L. Schulte, J. Mao, J. Reitz, S. Sreeramulu, D. Kudlinzki, V.-V. Hodirnau, J. Meier-Credo, K. Saxena, F. Buhr, J.D. Langer, M. Blackledge, A.S. Frangakis, C. Glaubitz, H. Schwalbe, Nature Communications 11 (2020).","ama":"Schulte L, Mao J, Reitz J, et al. Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-19372-x\">10.1038/s41467-020-19372-x</a>","mla":"Schulte, Linda, et al. “Cysteine Oxidation and Disulfide Formation in the Ribosomal Exit Tunnel.” <i>Nature Communications</i>, vol. 11, 5569, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-19372-x\">10.1038/s41467-020-19372-x</a>.","ista":"Schulte L, Mao J, Reitz J, Sreeramulu S, Kudlinzki D, Hodirnau V-V, Meier-Credo J, Saxena K, Buhr F, Langer JD, Blackledge M, Frangakis AS, Glaubitz C, Schwalbe H. 2020. Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. Nature Communications. 11, 5569.","ieee":"L. Schulte <i>et al.</i>, “Cysteine oxidation and disulfide formation in the ribosomal exit tunnel,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020."},"department":[{"_id":"EM-Fac"}],"oa":1,"_id":"8744","oa_version":"Published Version","file_date_updated":"2020-11-09T07:56:24Z","volume":11,"external_id":{"pmid":["33149120"],"isi":["000592028600001"]},"publisher":"Springer Nature","status":"public","has_accepted_license":"1","acknowledgement":"We acknowledge help from Anja Seybert, Margot Frangakis, Diana Grewe, Mikhail Eltsov, Utz Ermel, and Shintaro Aibara. The work was supported by Deutsche Forschungsgemeinschaft in the CLiC graduate school. Work at the Center for Biomolecular Magnetic Resonance (BMRZ) is supported by the German state of Hesse. The work at BMRZ has been supported by the state of Hesse. L.S. has been supported by the DFG graduate college: CLiC.","doi":"10.1038/s41467-020-19372-x","intvolume":"        11","isi":1,"type":"journal_article","author":[{"last_name":"Schulte","full_name":"Schulte, Linda","first_name":"Linda"},{"last_name":"Mao","full_name":"Mao, Jiafei","first_name":"Jiafei"},{"last_name":"Reitz","first_name":"Julian","full_name":"Reitz, Julian"},{"first_name":"Sridhar","full_name":"Sreeramulu, Sridhar","last_name":"Sreeramulu"},{"last_name":"Kudlinzki","full_name":"Kudlinzki, Denis","first_name":"Denis"},{"last_name":"Hodirnau","id":"3661B498-F248-11E8-B48F-1D18A9856A87","first_name":"Victor-Valentin","full_name":"Hodirnau, Victor-Valentin","orcid":"0000-0003-3904-947X"},{"first_name":"Jakob","full_name":"Meier-Credo, Jakob","last_name":"Meier-Credo"},{"last_name":"Saxena","full_name":"Saxena, Krishna","first_name":"Krishna"},{"last_name":"Buhr","full_name":"Buhr, Florian","first_name":"Florian"},{"last_name":"Langer","full_name":"Langer, Julian D.","first_name":"Julian D."},{"first_name":"Martin","full_name":"Blackledge, Martin","last_name":"Blackledge"},{"last_name":"Frangakis","first_name":"Achilleas S.","full_name":"Frangakis, Achilleas S."},{"last_name":"Glaubitz","first_name":"Clemens","full_name":"Glaubitz, Clemens"},{"first_name":"Harald","full_name":"Schwalbe, Harald","last_name":"Schwalbe"}],"publication_status":"published","pmid":1,"quality_controlled":"1","article_processing_charge":"No","article_number":"5569","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"abstract":[{"text":"Understanding the conformational sampling of translation-arrested ribosome nascent chain complexes is key to understand co-translational folding. Up to now, coupling of cysteine oxidation, disulfide bond formation and structure formation in nascent chains has remained elusive. Here, we investigate the eye-lens protein γB-crystallin in the ribosomal exit tunnel. Using mass spectrometry, theoretical simulations, dynamic nuclear polarization-enhanced solid-state nuclear magnetic resonance and cryo-electron microscopy, we show that thiol groups of cysteine residues undergo S-glutathionylation and S-nitrosylation and form non-native disulfide bonds. Thus, covalent modification chemistry occurs already prior to nascent chain release as the ribosome exit tunnel provides sufficient space even for disulfide bond formation which can guide protein folding.","lang":"eng"}],"publication_identifier":{"issn":["2041-1723"]},"file":[{"file_name":"2020_NatureComm_Schulte.pdf","checksum":"b2688f0347e69e6629bba582077278c5","creator":"dernst","content_type":"application/pdf","file_id":"8745","success":1,"relation":"main_file","date_updated":"2020-11-09T07:56:24Z","file_size":1670898,"date_created":"2020-11-09T07:56:24Z","access_level":"open_access"}],"language":[{"iso":"eng"}],"day":"04","title":"Cysteine oxidation and disulfide formation in the ribosomal exit tunnel","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","year":"2020","article_type":"original","month":"11","date_published":"2020-11-04T00:00:00Z","publication":"Nature Communications","date_updated":"2025-06-12T07:01:22Z","date_created":"2020-11-09T07:49:36Z","ddc":["570"]},{"date_published":"2020-12-22T00:00:00Z","month":"12","ddc":["570"],"date_updated":"2025-04-15T07:52:12Z","publication":"Nature Communications","date_created":"2020-12-23T08:25:45Z","title":"Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction","day":"22","article_type":"original","scopus_import":"1","year":"2020","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","file":[{"date_updated":"2020-12-28T08:16:10Z","file_size":3958727,"relation":"main_file","date_created":"2020-12-28T08:16:10Z","access_level":"open_access","checksum":"55d43ea0061cc4027ba45e966e1db8cc","creator":"dernst","file_name":"2020_NatureComm_Faessler.pdf","content_type":"application/pdf","success":1,"file_id":"8975"}],"abstract":[{"text":"The actin-related protein (Arp)2/3 complex nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen infection. Its activation is tightly regulated and involves complex structural rearrangements and actin filament binding, which are yet to be understood. Here, we report a 9.0 Å resolution structure of the actin filament Arp2/3 complex branch junction in cells using cryo-electron tomography and subtomogram averaging. This allows us to generate an accurate model of the active Arp2/3 complex in the branch junction and its interaction with actin filaments. Notably, our model reveals a previously undescribed set of interactions of the Arp2/3 complex with the mother filament, significantly different to the previous branch junction model. Our structure also indicates a central role for the ArpC3 subunit in stabilizing the active conformation.","lang":"eng"}],"publication_identifier":{"issn":["2041-1723"]},"language":[{"iso":"eng"}],"corr_author":"1","keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"author":[{"full_name":"Fäßler, Florian","orcid":"0000-0001-7149-769X","first_name":"Florian","id":"404F5528-F248-11E8-B48F-1D18A9856A87","last_name":"Fäßler"},{"last_name":"Dimchev","first_name":"Georgi A","id":"38C393BE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8370-6161","full_name":"Dimchev, Georgi A"},{"id":"3661B498-F248-11E8-B48F-1D18A9856A87","first_name":"Victor-Valentin","full_name":"Hodirnau, Victor-Valentin","orcid":"0000-0003-3904-947X","last_name":"Hodirnau"},{"full_name":"Wan, William","first_name":"William","last_name":"Wan"},{"last_name":"Schur","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","first_name":"Florian KM","full_name":"Schur, Florian KM","orcid":"0000-0003-4790-8078"}],"publication_status":"published","type":"journal_article","article_number":"6437","related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/cutting-edge-technology-reveals-structures-within-cells/","relation":"press_release"}]},"article_processing_charge":"No","quality_controlled":"1","acknowledgement":"This research was supported by the Scientific Service Units (SSUs) of IST Austria through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), the BioImaging Facility (BIF), and the Electron Microscopy Facility (EMF). We also thank Dimitry Tegunov (MPI for Biophysical Chemistry) for helpful discussions\r\nabout the M software, and Michael Sixt (IST Austria) and Klemens Rottner (Technical University Braunschweig, HZI Braunschweig) for critical reading of the manuscript. We also thank Gregory Voth (University of Chicago) for providing us the MD-derived branch junction model for comparison. The authors acknowledge support from IST Austria and from the Austrian Science Fund (FWF): M02495 to G.D. and Austrian Science Fund (FWF): P33367 to F.K.M.S. ","status":"public","has_accepted_license":"1","isi":1,"doi":"10.1038/s41467-020-20286-x","intvolume":"        11","external_id":{"isi":["000603078000003"]},"publisher":"Springer Nature","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"EM-Fac"}],"project":[{"grant_number":"P33367","_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A","name":"Structure and isoform diversity of the Arp2/3 complex"},{"grant_number":"M02495","_id":"2674F658-B435-11E9-9278-68D0E5697425","name":"Protein structure and function in filopodia across scales","call_identifier":"FWF"}],"department":[{"_id":"FlSc"},{"_id":"EM-Fac"}],"citation":{"ieee":"F. Fäßler, G. A. Dimchev, V.-V. Hodirnau, W. Wan, and F. K. Schur, “Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","mla":"Fäßler, Florian, et al. “Cryo-Electron Tomography Structure of Arp2/3 Complex in Cells Reveals New Insights into the Branch Junction.” <i>Nature Communications</i>, vol. 11, 6437, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-20286-x\">10.1038/s41467-020-20286-x</a>.","ista":"Fäßler F, Dimchev GA, Hodirnau V-V, Wan W, Schur FK. 2020. Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. Nature Communications. 11, 6437.","short":"F. Fäßler, G.A. Dimchev, V.-V. Hodirnau, W. Wan, F.K. Schur, Nature Communications 11 (2020).","apa":"Fäßler, F., Dimchev, G. A., Hodirnau, V.-V., Wan, W., &#38; Schur, F. K. (2020). Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-20286-x\">https://doi.org/10.1038/s41467-020-20286-x</a>","ama":"Fäßler F, Dimchev GA, Hodirnau V-V, Wan W, Schur FK. Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-20286-x\">10.1038/s41467-020-20286-x</a>","chicago":"Fäßler, Florian, Georgi A Dimchev, Victor-Valentin Hodirnau, William Wan, and Florian KM Schur. “Cryo-Electron Tomography Structure of Arp2/3 Complex in Cells Reveals New Insights into the Branch Junction.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-20286-x\">https://doi.org/10.1038/s41467-020-20286-x</a>."},"file_date_updated":"2020-12-28T08:16:10Z","volume":11,"oa_version":"Published Version","_id":"8971","oa":1},{"date_published":"2020-06-01T00:00:00Z","month":"06","ddc":["530"],"date_updated":"2021-02-18T14:57:39Z","publication":"New Journal of Physics","date_created":"2021-02-18T14:17:32Z","title":"Focus on active colloids and nanoparticles","day":"01","year":"2020","scopus_import":"1","article_type":"letter_note","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","file":[{"content_type":"application/pdf","file_id":"9169","success":1,"checksum":"02759f3ab228c1a061e747155a20f851","creator":"cziletti","file_name":"2020_NewJournPhys_Speck.pdf","file_size":953338,"date_updated":"2021-02-18T14:53:33Z","relation":"main_file","date_created":"2021-02-18T14:53:33Z","access_level":"open_access"}],"publication_identifier":{"issn":["1367-2630"]},"language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"published","author":[{"full_name":"Speck, Thomas","first_name":"Thomas","last_name":"Speck"},{"full_name":"Tailleur, Julien","first_name":"Julien","last_name":"Tailleur"},{"id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","first_name":"Jérémie A","full_name":"Palacci, Jérémie A","orcid":"0000-0002-7253-9465","last_name":"Palacci"}],"type":"journal_article","extern":"1","article_number":"060201","quality_controlled":"1","article_processing_charge":"No","has_accepted_license":"1","issue":"6","status":"public","doi":"10.1088/1367-2630/ab90d9","intvolume":"        22","publisher":"IOP Publishing","citation":{"short":"T. Speck, J. Tailleur, J.A. Palacci, New Journal of Physics 22 (2020).","apa":"Speck, T., Tailleur, J., &#38; Palacci, J. A. (2020). Focus on active colloids and nanoparticles. <i>New Journal of Physics</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1367-2630/ab90d9\">https://doi.org/10.1088/1367-2630/ab90d9</a>","ama":"Speck T, Tailleur J, Palacci JA. Focus on active colloids and nanoparticles. <i>New Journal of Physics</i>. 2020;22(6). doi:<a href=\"https://doi.org/10.1088/1367-2630/ab90d9\">10.1088/1367-2630/ab90d9</a>","chicago":"Speck, Thomas, Julien Tailleur, and Jérémie A Palacci. “Focus on Active Colloids and Nanoparticles.” <i>New Journal of Physics</i>. IOP Publishing, 2020. <a href=\"https://doi.org/10.1088/1367-2630/ab90d9\">https://doi.org/10.1088/1367-2630/ab90d9</a>.","ieee":"T. Speck, J. Tailleur, and J. A. Palacci, “Focus on active colloids and nanoparticles,” <i>New Journal of Physics</i>, vol. 22, no. 6. IOP Publishing, 2020.","ista":"Speck T, Tailleur J, Palacci JA. 2020. Focus on active colloids and nanoparticles. New Journal of Physics. 22(6), 060201.","mla":"Speck, Thomas, et al. “Focus on Active Colloids and Nanoparticles.” <i>New Journal of Physics</i>, vol. 22, no. 6, 060201, IOP Publishing, 2020, doi:<a href=\"https://doi.org/10.1088/1367-2630/ab90d9\">10.1088/1367-2630/ab90d9</a>."},"file_date_updated":"2021-02-18T14:53:33Z","volume":22,"_id":"9164","oa_version":"Published Version","oa":1},{"author":[{"last_name":"Li","first_name":"Xiang","id":"4B7E523C-F248-11E8-B48F-1D18A9856A87","full_name":"Li, Xiang"},{"last_name":"Yakaboylu","first_name":"Enderalp","id":"38CB71F6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5973-0874","full_name":"Yakaboylu, Enderalp"},{"last_name":"Bighin","first_name":"Giacomo","id":"4CA96FD4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8823-9777","full_name":"Bighin, Giacomo"},{"first_name":"Richard","full_name":"Schmidt, Richard","last_name":"Schmidt"},{"orcid":"0000-0002-6990-7802","full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","first_name":"Mikhail","last_name":"Lemeshko"},{"full_name":"Deuchert, Andreas","orcid":"0000-0003-3146-6746","first_name":"Andreas","id":"4DA65CD0-F248-11E8-B48F-1D18A9856A87","last_name":"Deuchert"}],"publication_status":"published","type":"journal_article","related_material":{"record":[{"id":"8958","status":"public","relation":"dissertation_contains"}]},"article_number":"164302","article_processing_charge":"No","quality_controlled":"1","pmid":1,"status":"public","issue":"16","acknowledgement":"We are grateful to Areg Ghazaryan for valuable discussions. M.L. acknowledges support from the Austrian Science Fund (FWF) under Project No. P29902-N27 and from the European Research Council (ERC) Starting Grant No. 801770 (ANGULON). G.B. acknowledges support from the Austrian Science Fund (FWF) under Project No. M2461-N27. A.D. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the European Research Council (ERC) Grant Agreement No. 694227 and under the Marie Sklodowska-Curie Grant Agreement No. 836146. R.S. was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2111 – 390814868.","isi":1,"intvolume":"       152","doi":"10.1063/1.5144759","publisher":"AIP Publishing","external_id":{"pmid":["32357791"],"arxiv":["1912.02658"],"isi":["000530448300001"]},"arxiv":1,"citation":{"mla":"Li, Xiang, et al. “Intermolecular Forces and Correlations Mediated by a Phonon Bath.” <i>The Journal of Chemical Physics</i>, vol. 152, no. 16, 164302, AIP Publishing, 2020, doi:<a href=\"https://doi.org/10.1063/1.5144759\">10.1063/1.5144759</a>.","ista":"Li X, Yakaboylu E, Bighin G, Schmidt R, Lemeshko M, Deuchert A. 2020. Intermolecular forces and correlations mediated by a phonon bath. The Journal of Chemical Physics. 152(16), 164302.","ieee":"X. Li, E. Yakaboylu, G. Bighin, R. Schmidt, M. Lemeshko, and A. Deuchert, “Intermolecular forces and correlations mediated by a phonon bath,” <i>The Journal of Chemical Physics</i>, vol. 152, no. 16. AIP Publishing, 2020.","chicago":"Li, Xiang, Enderalp Yakaboylu, Giacomo Bighin, Richard Schmidt, Mikhail Lemeshko, and Andreas Deuchert. “Intermolecular Forces and Correlations Mediated by a Phonon Bath.” <i>The Journal of Chemical Physics</i>. AIP Publishing, 2020. <a href=\"https://doi.org/10.1063/1.5144759\">https://doi.org/10.1063/1.5144759</a>.","short":"X. Li, E. Yakaboylu, G. Bighin, R. Schmidt, M. Lemeshko, A. Deuchert, The Journal of Chemical Physics 152 (2020).","ama":"Li X, Yakaboylu E, Bighin G, Schmidt R, Lemeshko M, Deuchert A. Intermolecular forces and correlations mediated by a phonon bath. <i>The Journal of Chemical Physics</i>. 2020;152(16). doi:<a href=\"https://doi.org/10.1063/1.5144759\">10.1063/1.5144759</a>","apa":"Li, X., Yakaboylu, E., Bighin, G., Schmidt, R., Lemeshko, M., &#38; Deuchert, A. (2020). Intermolecular forces and correlations mediated by a phonon bath. <i>The Journal of Chemical Physics</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/1.5144759\">https://doi.org/10.1063/1.5144759</a>"},"department":[{"_id":"MiLe"},{"_id":"RoSe"}],"project":[{"grant_number":"P29902","_id":"26031614-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Quantum rotations in the presence of a many-body environment"},{"name":"Angulon: physics and applications of a new quasiparticle","call_identifier":"H2020","grant_number":"801770","_id":"2688CF98-B435-11E9-9278-68D0E5697425"},{"_id":"26986C82-B435-11E9-9278-68D0E5697425","grant_number":"M02641","name":"A path-integral approach to composite impurities","call_identifier":"FWF"},{"grant_number":"694227","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Analysis of quantum many-body systems"}],"volume":152,"_id":"8587","oa_version":"Preprint","oa":1,"date_published":"2020-04-27T00:00:00Z","ec_funded":1,"month":"04","date_created":"2020-09-30T10:33:17Z","publication":"The Journal of Chemical Physics","date_updated":"2026-04-08T07:26:09Z","title":"Intermolecular forces and correlations mediated by a phonon bath","day":"27","article_type":"original","year":"2020","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://arxiv.org/abs/1912.02658","open_access":"1"}],"abstract":[{"lang":"eng","text":"Inspired by the possibility to experimentally manipulate and enhance chemical reactivity in helium nanodroplets, we investigate the effective interaction and the resulting correlations between two diatomic molecules immersed in a bath of bosons. By analogy with the bipolaron, we introduce the biangulon quasiparticle describing two rotating molecules that align with respect to each other due to the effective attractive interaction mediated by the excitations of the bath. We study this system in different parameter regimes and apply several theoretical approaches to describe its properties. Using a Born–Oppenheimer approximation, we investigate the dependence of the effective intermolecular interaction on the rotational state of the two molecules. In the strong-coupling regime, a product-state ansatz shows that the molecules tend to have a strong alignment in the ground state. To investigate the system in the weak-coupling regime, we apply a one-phonon excitation variational ansatz, which allows us to access the energy spectrum. In comparison to the angulon quasiparticle, the biangulon shows shifted angulon instabilities and an additional spectral instability, where resonant angular momentum transfer between the molecules and the bath takes place. These features are proposed as an experimentally observable signature for the formation of the biangulon quasiparticle. Finally, by using products of single angulon and bare impurity wave functions as basis states, we introduce a diagonalization scheme that allows us to describe the transition from two separated angulons to a biangulon as a function of the distance between the two molecules."}],"publication_identifier":{"eissn":["1089-7690"],"issn":["0021-9606"]},"language":[{"iso":"eng"}],"corr_author":"1","keyword":["Physical and Theoretical Chemistry","General Physics and Astronomy"]},{"acknowledged_ssus":[{"_id":"NanoFab"}],"publisher":"Springer Nature","external_id":{"pmid":["32901014"],"isi":["000577280200001"]},"citation":{"ista":"Arnold GM, Wulf M, Barzanjeh S, Redchenko E, Rueda Sanchez AR, Hease WJ, Hassani F, Fink JM. 2020. Converting microwave and telecom photons with a silicon photonic nanomechanical interface. Nature Communications. 11, 4460.","mla":"Arnold, Georg M., et al. “Converting Microwave and Telecom Photons with a Silicon Photonic Nanomechanical Interface.” <i>Nature Communications</i>, vol. 11, 4460, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-18269-z\">10.1038/s41467-020-18269-z</a>.","ieee":"G. M. Arnold <i>et al.</i>, “Converting microwave and telecom photons with a silicon photonic nanomechanical interface,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","chicago":"Arnold, Georg M, Matthias Wulf, Shabir Barzanjeh, Elena Redchenko, Alfredo R Rueda Sanchez, William J Hease, Farid Hassani, and Johannes M Fink. “Converting Microwave and Telecom Photons with a Silicon Photonic Nanomechanical Interface.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-18269-z\">https://doi.org/10.1038/s41467-020-18269-z</a>.","short":"G.M. Arnold, M. Wulf, S. Barzanjeh, E. Redchenko, A.R. Rueda Sanchez, W.J. Hease, F. Hassani, J.M. Fink, Nature Communications 11 (2020).","apa":"Arnold, G. M., Wulf, M., Barzanjeh, S., Redchenko, E., Rueda Sanchez, A. R., Hease, W. J., … Fink, J. M. (2020). Converting microwave and telecom photons with a silicon photonic nanomechanical interface. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-18269-z\">https://doi.org/10.1038/s41467-020-18269-z</a>","ama":"Arnold GM, Wulf M, Barzanjeh S, et al. Converting microwave and telecom photons with a silicon photonic nanomechanical interface. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-18269-z\">10.1038/s41467-020-18269-z</a>"},"department":[{"_id":"JoFi"}],"project":[{"_id":"257EB838-B435-11E9-9278-68D0E5697425","grant_number":"732894","call_identifier":"H2020","name":"Hybrid Optomechanical Technologies"},{"call_identifier":"H2020","name":"A Fiber Optic Transceiver for Superconducting Qubits","_id":"26336814-B435-11E9-9278-68D0E5697425","grant_number":"758053"},{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"},{"name":"Quantum readout techniques and technologies","call_identifier":"H2020","_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E","grant_number":"862644"},{"_id":"2671EB66-B435-11E9-9278-68D0E5697425","name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies"}],"oa":1,"_id":"8529","oa_version":"Published Version","file_date_updated":"2020-09-18T13:02:37Z","volume":11,"type":"journal_article","author":[{"first_name":"Georg M","id":"3770C838-F248-11E8-B48F-1D18A9856A87","full_name":"Arnold, Georg M","orcid":"0000-0003-1397-7876","last_name":"Arnold"},{"first_name":"Matthias","id":"45598606-F248-11E8-B48F-1D18A9856A87","full_name":"Wulf, Matthias","orcid":"0000-0001-6613-1378","last_name":"Wulf"},{"orcid":"0000-0003-0415-1423","full_name":"Barzanjeh, Shabir","id":"2D25E1F6-F248-11E8-B48F-1D18A9856A87","first_name":"Shabir","last_name":"Barzanjeh"},{"full_name":"Redchenko, Elena","first_name":"Elena","id":"2C21D6E8-F248-11E8-B48F-1D18A9856A87","last_name":"Redchenko"},{"last_name":"Rueda Sanchez","orcid":"0000-0001-6249-5860","full_name":"Rueda Sanchez, Alfredo R","first_name":"Alfredo R","id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87"},{"first_name":"William J","id":"29705398-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9868-2166","full_name":"Hease, William J","last_name":"Hease"},{"last_name":"Hassani","first_name":"Farid","id":"2AED110C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6937-5773","full_name":"Hassani, Farid"},{"last_name":"Fink","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes M","full_name":"Fink, Johannes M","orcid":"0000-0001-8112-028X"}],"publication_status":"published","article_processing_charge":"No","quality_controlled":"1","pmid":1,"related_material":{"record":[{"relation":"research_data","id":"13056","status":"public"},{"relation":"dissertation_contains","id":"18871","status":"public"}],"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41467-020-18912-9"},{"url":"https://ist.ac.at/en/news/how-to-transport-microwave-quantum-information-via-optical-fiber/","relation":"press_release","description":"News on IST Homepage"}]},"article_number":"4460","status":"public","has_accepted_license":"1","acknowledgement":"We thank Yuan Chen for performing supplementary FEM simulations and Andrew Higginbotham, Ralf Riedinger, Sungkun Hong, and Lorenzo Magrini for valuable discussions. This work was supported by IST Austria, the IST nanofabrication facility (NFF), the European Union’s Horizon 2020 research and innovation program under grant agreement no. 732894 (FET Proactive HOT) and the European Research Council under grant agreement no. 758053 (ERC StG QUNNECT). G.A. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. W.H. is the recipient of an ISTplus postdoctoral fellowship with funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 754411. J.M.F. acknowledges support from the Austrian Science Fund (FWF) through BeyondC (F71), a NOMIS foundation research grant, and the EU’s Horizon 2020 research and innovation program under grant agreement no. 862644 (FET Open QUARTET).","intvolume":"        11","doi":"10.1038/s41467-020-18269-z","isi":1,"publication_identifier":{"issn":["2041-1723"]},"abstract":[{"text":"Practical quantum networks require low-loss and noise-resilient optical interconnects as well as non-Gaussian resources for entanglement distillation and distributed quantum computation. The latter could be provided by superconducting circuits but existing solutions to interface the microwave and optical domains lack either scalability or efficiency, and in most cases the conversion noise is not known. In this work we utilize the unique opportunities of silicon photonics, cavity optomechanics and superconducting circuits to demonstrate a fully integrated, coherent transducer interfacing the microwave X and the telecom S bands with a total (internal) bidirectional transduction efficiency of 1.2% (135%) at millikelvin temperatures. The coupling relies solely on the radiation pressure interaction mediated by the femtometer-scale motion of two silicon nanobeams reaching a <jats:italic>V</jats:italic><jats:sub><jats:italic>π</jats:italic></jats:sub> as low as 16 μV for sub-nanowatt pump powers. Without the associated optomechanical gain, we achieve a total (internal) pure conversion efficiency of up to 0.019% (1.6%), relevant for future noise-free operation on this qubit-compatible platform.","lang":"eng"}],"file":[{"creator":"dernst","checksum":"88f92544889eb18bb38e25629a422a86","file_name":"2020_NatureComm_Arnold.pdf","success":1,"file_id":"8530","content_type":"application/pdf","access_level":"open_access","date_created":"2020-09-18T13:02:37Z","file_size":1002818,"relation":"main_file","date_updated":"2020-09-18T13:02:37Z"}],"corr_author":"1","language":[{"iso":"eng"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"ec_funded":1,"month":"09","date_published":"2020-09-08T00:00:00Z","date_created":"2020-09-18T10:56:20Z","date_updated":"2026-06-07T22:31:11Z","publication":"Nature Communications","ddc":["530"],"day":"08","title":"Converting microwave and telecom photons with a silicon photonic nanomechanical interface","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","year":"2020","article_type":"original"},{"publication_status":"published","author":[{"last_name":"Zhou","first_name":"H.","full_name":"Zhou, H."},{"last_name":"Polshyn","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy","full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896"},{"last_name":"Taniguchi","full_name":"Taniguchi, T.","first_name":"T."},{"last_name":"Watanabe","full_name":"Watanabe, K.","first_name":"K."},{"full_name":"Young, A. F.","first_name":"A. F.","last_name":"Young"}],"extern":"1","type":"journal_article","article_processing_charge":"No","quality_controlled":"1","issue":"2","status":"public","acknowledgement":"We acknowledge discussions with B. Halperin, C. Huang, A. Macdonald and M. Zalatel. Experimental work at UCSB was supported by the Army Research Office under awards nos. MURI W911NF-16-1-0361 and W911NF-16-1-0482. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by MEXT (Japan) and CREST (JPMJCR15F3), JST. A.F.Y. acknowledges the support of the David and Lucile Packard Foundation and and Alfred. P. Sloan Foundation.","intvolume":"        16","doi":"10.1038/s41567-019-0729-8","publisher":"Springer Nature","citation":{"short":"H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, A.F. Young, Nature Physics 16 (2019) 154–158.","apa":"Zhou, H., Polshyn, H., Taniguchi, T., Watanabe, K., &#38; Young, A. F. (2019). Solids of quantum Hall skyrmions in graphene. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-019-0729-8\">https://doi.org/10.1038/s41567-019-0729-8</a>","ama":"Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. Solids of quantum Hall skyrmions in graphene. <i>Nature Physics</i>. 2019;16(2):154-158. doi:<a href=\"https://doi.org/10.1038/s41567-019-0729-8\">10.1038/s41567-019-0729-8</a>","chicago":"Zhou, H., Hryhoriy Polshyn, T. Taniguchi, K. Watanabe, and A. F. Young. “Solids of Quantum Hall Skyrmions in Graphene.” <i>Nature Physics</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41567-019-0729-8\">https://doi.org/10.1038/s41567-019-0729-8</a>.","ieee":"H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, and A. F. Young, “Solids of quantum Hall skyrmions in graphene,” <i>Nature Physics</i>, vol. 16, no. 2. Springer Nature, pp. 154–158, 2019.","ista":"Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. 2019. Solids of quantum Hall skyrmions in graphene. Nature Physics. 16(2), 154–158.","mla":"Zhou, H., et al. “Solids of Quantum Hall Skyrmions in Graphene.” <i>Nature Physics</i>, vol. 16, no. 2, Springer Nature, 2019, pp. 154–58, doi:<a href=\"https://doi.org/10.1038/s41567-019-0729-8\">10.1038/s41567-019-0729-8</a>."},"volume":16,"_id":"10620","oa_version":"None","date_published":"2019-12-16T00:00:00Z","month":"12","page":"154-158","date_created":"2022-01-13T14:45:16Z","date_updated":"2022-01-13T15:34:44Z","publication":"Nature Physics","title":"Solids of quantum Hall skyrmions in graphene","day":"16","year":"2019","scopus_import":"1","article_type":"original","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","abstract":[{"lang":"eng","text":"Partially filled Landau levels host competing electronic orders. For example, electron solids may prevail close to integer filling of the Landau levels before giving way to fractional quantum Hall liquids at higher carrier density1,2. Here, we report the observation of an electron solid with non-collinear spin texture in monolayer graphene, consistent with solidification of skyrmions3—topological spin textures characterized by quantized electrical charge4,5. We probe the spin texture of the solids using a modified Corbino geometry that allows ferromagnetic magnons to be launched and detected6,7. We find that magnon transport is highly efficient when one Landau level is filled (ν=1), consistent with quantum Hall ferromagnetic spin polarization. However, even minimal doping immediately quenches the magnon signal while leaving the vanishing low-temperature charge conductivity unchanged. Our results can be understood by the formation of a solid of charged skyrmions near ν=1, whose non-collinear spin texture leads to rapid magnon decay. Data near fractional fillings show evidence of several fractional skyrmion solids, suggesting that graphene hosts a highly tunable landscape of coupled spin and charge orders."}],"publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy"]},{"issue":"10","acknowledgement":"The authors thank S. Das Sarma and F. Wu for sharing their unpublished theoretical results, and acknowledge further discussions with L. Balents and T. Senthil. Work at both Columbia and UCSB was funded by the Army Research Office under award W911NF-17-1-0323. Sample device design and fabrication was partially supported by DoE Pro-QM EFRC (DE-SC0019443). A.F.Y. and C.R.D. separately acknowledge the support of the David and Lucile Packard Foundation. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by the MEXT, Japan and the CREST (JPMJCR15F3), JST. A portion of this work was carried out at the KITP, Santa Barbara, supported by the National Science Foundation under grant number NSF PHY-1748958.","status":"public","intvolume":"        15","doi":"10.1038/s41567-019-0596-3","author":[{"id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","first_name":"Hryhoriy","full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896","last_name":"Polshyn"},{"first_name":"Matthew","full_name":"Yankowitz, Matthew","last_name":"Yankowitz"},{"last_name":"Chen","first_name":"Shaowen","full_name":"Chen, Shaowen"},{"full_name":"Zhang, Yuxuan","first_name":"Yuxuan","last_name":"Zhang"},{"last_name":"Watanabe","first_name":"K.","full_name":"Watanabe, K."},{"full_name":"Taniguchi, T.","first_name":"T.","last_name":"Taniguchi"},{"last_name":"Dean","first_name":"Cory R.","full_name":"Dean, Cory R."},{"last_name":"Young","full_name":"Young, Andrea F.","first_name":"Andrea F."}],"publication_status":"published","extern":"1","type":"journal_article","quality_controlled":"1","article_processing_charge":"No","citation":{"ista":"Polshyn H, Yankowitz M, Chen S, Zhang Y, Watanabe K, Taniguchi T, Dean CR, Young AF. 2019. Large linear-in-temperature resistivity in twisted bilayer graphene. Nature Physics. 15(10), 1011–1016.","mla":"Polshyn, Hryhoriy, et al. “Large Linear-in-Temperature Resistivity in Twisted Bilayer Graphene.” <i>Nature Physics</i>, vol. 15, no. 10, Springer Nature, 2019, pp. 1011–16, doi:<a href=\"https://doi.org/10.1038/s41567-019-0596-3\">10.1038/s41567-019-0596-3</a>.","ieee":"H. Polshyn <i>et al.</i>, “Large linear-in-temperature resistivity in twisted bilayer graphene,” <i>Nature Physics</i>, vol. 15, no. 10. Springer Nature, pp. 1011–1016, 2019.","chicago":"Polshyn, Hryhoriy, Matthew Yankowitz, Shaowen Chen, Yuxuan Zhang, K. Watanabe, T. Taniguchi, Cory R. Dean, and Andrea F. Young. “Large Linear-in-Temperature Resistivity in Twisted Bilayer Graphene.” <i>Nature Physics</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41567-019-0596-3\">https://doi.org/10.1038/s41567-019-0596-3</a>.","ama":"Polshyn H, Yankowitz M, Chen S, et al. Large linear-in-temperature resistivity in twisted bilayer graphene. <i>Nature Physics</i>. 2019;15(10):1011-1016. doi:<a href=\"https://doi.org/10.1038/s41567-019-0596-3\">10.1038/s41567-019-0596-3</a>","apa":"Polshyn, H., Yankowitz, M., Chen, S., Zhang, Y., Watanabe, K., Taniguchi, T., … Young, A. F. (2019). Large linear-in-temperature resistivity in twisted bilayer graphene. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-019-0596-3\">https://doi.org/10.1038/s41567-019-0596-3</a>","short":"H. Polshyn, M. Yankowitz, S. Chen, Y. Zhang, K. Watanabe, T. Taniguchi, C.R. Dean, A.F. Young, Nature Physics 15 (2019) 1011–1016."},"volume":15,"_id":"10621","oa_version":"Preprint","oa":1,"publisher":"Springer Nature","external_id":{"arxiv":["1902.00763"]},"arxiv":1,"title":"Large linear-in-temperature resistivity in twisted bilayer graphene","day":"05","year":"2019","scopus_import":"1","article_type":"original","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_published":"2019-08-05T00:00:00Z","month":"08","page":"1011-1016","date_created":"2022-01-13T15:00:58Z","date_updated":"2022-01-20T09:33:38Z","publication":"Nature Physics","keyword":["general physics and astronomy"],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1902.00763"}],"publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"abstract":[{"lang":"eng","text":"Twisted bilayer graphene has recently emerged as a platform for hosting correlated phenomena. For twist angles near θ ≈ 1.1°, the low-energy electronic structure of twisted bilayer graphene features isolated bands with a flat dispersion1,2. Recent experiments have observed a variety of low-temperature phases that appear to be driven by electron interactions, including insulating states, superconductivity and magnetism3,4,5,6. Here we report electrical transport measurements up to room temperature for twist angles varying between 0.75° and 2°. We find that the resistivity, ρ, scales linearly with temperature, T, over a wide range of T before falling again owing to interband activation. The T-linear response is much larger than observed in monolayer graphene for all measured devices, and in particular increases by more than three orders of magnitude in the range where the flat band exists. Our results point to the dominant role of electron–phonon scattering in twisted bilayer graphene, with possible implications for the origin of the observed superconductivity."}],"language":[{"iso":"eng"}]},{"status":"public","doi":"10.1038/s41467-019-10490-9","intvolume":"        10","author":[{"full_name":"Gauto, Diego F.","first_name":"Diego F.","last_name":"Gauto"},{"last_name":"Estrozi","first_name":"Leandro F.","full_name":"Estrozi, Leandro F."},{"last_name":"Schwieters","first_name":"Charles D.","full_name":"Schwieters, Charles D."},{"first_name":"Gregory","full_name":"Effantin, Gregory","last_name":"Effantin"},{"first_name":"Pavel","full_name":"Macek, Pavel","last_name":"Macek"},{"last_name":"Sounier","first_name":"Remy","full_name":"Sounier, Remy"},{"full_name":"Sivertsen, Astrid C.","first_name":"Astrid C.","last_name":"Sivertsen"},{"last_name":"Schmidt","first_name":"Elena","full_name":"Schmidt, Elena"},{"full_name":"Kerfah, Rime","first_name":"Rime","last_name":"Kerfah"},{"full_name":"Mas, Guillaume","first_name":"Guillaume","last_name":"Mas"},{"last_name":"Colletier","full_name":"Colletier, Jacques-Philippe","first_name":"Jacques-Philippe"},{"last_name":"Güntert","first_name":"Peter","full_name":"Güntert, Peter"},{"last_name":"Favier","first_name":"Adrien","full_name":"Favier, Adrien"},{"last_name":"Schoehn","first_name":"Guy","full_name":"Schoehn, Guy"},{"id":"7B541462-FAF6-11E9-A490-E8DFE5697425","first_name":"Paul","orcid":"0000-0002-9350-7606","full_name":"Schanda, Paul","last_name":"Schanda"},{"first_name":"Jerome","full_name":"Boisbouvier, Jerome","last_name":"Boisbouvier"}],"publication_status":"published","type":"journal_article","extern":"1","article_number":"2697","pmid":1,"article_processing_charge":"No","quality_controlled":"1","citation":{"ama":"Gauto DF, Estrozi LF, Schwieters CD, et al. Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-10490-9\">10.1038/s41467-019-10490-9</a>","short":"D.F. Gauto, L.F. Estrozi, C.D. Schwieters, G. Effantin, P. Macek, R. Sounier, A.C. Sivertsen, E. Schmidt, R. Kerfah, G. Mas, J.-P. Colletier, P. Güntert, A. Favier, G. Schoehn, P. Schanda, J. Boisbouvier, Nature Communications 10 (2019).","apa":"Gauto, D. F., Estrozi, L. F., Schwieters, C. D., Effantin, G., Macek, P., Sounier, R., … Boisbouvier, J. (2019). Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-10490-9\">https://doi.org/10.1038/s41467-019-10490-9</a>","chicago":"Gauto, Diego F., Leandro F. Estrozi, Charles D. Schwieters, Gregory Effantin, Pavel Macek, Remy Sounier, Astrid C. Sivertsen, et al. “Integrated NMR and Cryo-EM Atomic-Resolution Structure Determination of a Half-Megadalton Enzyme Complex.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-10490-9\">https://doi.org/10.1038/s41467-019-10490-9</a>.","ieee":"D. F. Gauto <i>et al.</i>, “Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","ista":"Gauto DF, Estrozi LF, Schwieters CD, Effantin G, Macek P, Sounier R, Sivertsen AC, Schmidt E, Kerfah R, Mas G, Colletier J-P, Güntert P, Favier A, Schoehn G, Schanda P, Boisbouvier J. 2019. Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex. Nature Communications. 10, 2697.","mla":"Gauto, Diego F., et al. “Integrated NMR and Cryo-EM Atomic-Resolution Structure Determination of a Half-Megadalton Enzyme Complex.” <i>Nature Communications</i>, vol. 10, 2697, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-10490-9\">10.1038/s41467-019-10490-9</a>."},"volume":10,"oa_version":"Published Version","_id":"8405","oa":1,"external_id":{"pmid":["31217444"]},"publisher":"Springer Nature","title":"Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex","day":"19","year":"2019","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2019-06-19T00:00:00Z","month":"06","date_updated":"2021-01-12T08:19:03Z","publication":"Nature Communications","date_created":"2020-09-17T10:28:25Z","keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-019-10490-9"}],"publication_identifier":{"issn":["2041-1723"]},"abstract":[{"lang":"eng","text":"Atomic-resolution structure determination is crucial for understanding protein function. Cryo-EM and NMR spectroscopy both provide structural information, but currently cryo-EM does not routinely give access to atomic-level structural data, and, generally, NMR structure determination is restricted to small (<30 kDa) proteins. We introduce an integrated structure determination approach that simultaneously uses NMR and EM data to overcome the limits of each of these methods. The approach enables structure determination of the 468 kDa large dodecameric aminopeptidase TET2 to a precision and accuracy below 1 Å by combining secondary-structure information obtained from near-complete magic-angle-spinning NMR assignments of the 39 kDa-large subunits, distance restraints from backbone amides and ILV methyl groups, and a 4.1 Å resolution EM map. The resulting structure exceeds current standards of NMR and EM structure determination in terms of molecular weight and precision. Importantly, the approach is successful even in cases where only medium-resolution cryo-EM data are available."}],"language":[{"iso":"eng"}]}]