[{"doi":"10.1021/jacs.4c09111","article_processing_charge":"Yes (in subscription journal)","publisher":"American Chemical Society","publication_identifier":{"issn":["0002-7863"],"eissn":["1520-5126"]},"publication_status":"published","citation":{"mla":"Sood, Ankush, et al. “Simultaneous Formation of a Foldamer and a Self-Replicator by out-of-Equilibrium Dynamic Covalent Chemistry.” <i>Journal of the American Chemical Society</i>, vol. 146, no. 49, American Chemical Society, 2024, pp. 33386–94, doi:<a href=\"https://doi.org/10.1021/jacs.4c09111\">10.1021/jacs.4c09111</a>.","ieee":"A. Sood <i>et al.</i>, “Simultaneous formation of a foldamer and a self-replicator by out-of-equilibrium dynamic covalent chemistry,” <i>Journal of the American Chemical Society</i>, vol. 146, no. 49. American Chemical Society, pp. 33386–33394, 2024.","ista":"Sood A, Mandal PK, Ottelé J, Wu J, Eleveld M, Hatai J, Pappas CG, Huc I, Otto S. 2024. Simultaneous formation of a foldamer and a self-replicator by out-of-equilibrium dynamic covalent chemistry. Journal of the American Chemical Society. 146(49), 33386–33394.","chicago":"Sood, Ankush, Pradeep K Mandal, Jim Ottelé, Juntian Wu, Marcel Eleveld, Joydev Hatai, Charalampos G. Pappas, Ivan Huc, and Sijbren Otto. “Simultaneous Formation of a Foldamer and a Self-Replicator by out-of-Equilibrium Dynamic Covalent Chemistry.” <i>Journal of the American Chemical Society</i>. American Chemical Society, 2024. <a href=\"https://doi.org/10.1021/jacs.4c09111\">https://doi.org/10.1021/jacs.4c09111</a>.","ama":"Sood A, Mandal PK, Ottelé J, et al. Simultaneous formation of a foldamer and a self-replicator by out-of-equilibrium dynamic covalent chemistry. <i>Journal of the American Chemical Society</i>. 2024;146(49):33386-33394. doi:<a href=\"https://doi.org/10.1021/jacs.4c09111\">10.1021/jacs.4c09111</a>","apa":"Sood, A., Mandal, P. K., Ottelé, J., Wu, J., Eleveld, M., Hatai, J., … Otto, S. (2024). Simultaneous formation of a foldamer and a self-replicator by out-of-equilibrium dynamic covalent chemistry. <i>Journal of the American Chemical Society</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/jacs.4c09111\">https://doi.org/10.1021/jacs.4c09111</a>","short":"A. Sood, P.K. Mandal, J. Ottelé, J. Wu, M. Eleveld, J. Hatai, C.G. Pappas, I. Huc, S. Otto, Journal of the American Chemical Society 146 (2024) 33386–33394."},"date_published":"2024-11-26T00:00:00Z","year":"2024","title":"Simultaneous formation of a foldamer and a self-replicator by out-of-equilibrium dynamic covalent chemistry","month":"11","date_updated":"2026-01-19T10:57:53Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"external_id":{"pmid":["39590110"]},"quality_controlled":"1","oa_version":"Published Version","day":"26","volume":146,"OA_type":"hybrid","article_type":"original","abstract":[{"lang":"eng","text":"Systems chemistry has emerged as a useful paradigm to access structures and phenomena typically exhibited by living systems, including complex molecular systems such as self-replicators and foldamers. As we progress further toward the noncovalent synthesis of life-like systems, and eventually life itself, it is necessary to gain control over assembly pathways. Dissipative chemical fueling has enabled access to stable populations of (self-assembled) structures that would normally form only transiently. Here, we report a synthetic dynamic combinatorial library, made from a single structurally simple building block, from which a self-replicator and a foldamer can emerge along two distinct and competing pathways through an inter- or intramolecular assembly process, respectively. A fueled chemical reaction cycle is then set up to generate the foldamer transiently, in the presence of the self-replicator. The partitioning of the building block between the folding and self-replication pathways and the duration of the fueled reaction cycles are controlled by adjusting the amount of the chemical fuel. An out-of-equilibrium steady state involving the two assemblies could also be achieved by using a continuous stirred tank reactor with inflow and outflow of material. This work connects the domains of folding and self-replication in synthetic systems through dissipative out-of-equilibrium chemistry. It demonstrates that foldamers and self-replicators, formed from the same building block, can stably coexist if the system is continuously supplied with energy, while at equilibrium, the Gibbs phase rule prohibits such coexistence."}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1021/jacs.4c09111"}],"OA_place":"publisher","_id":"20962","oa":1,"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Ankush","full_name":"Sood, Ankush","last_name":"Sood"},{"first_name":"Pradeep K","orcid":"0000-0001-5996-956X","last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","full_name":"Mandal, Pradeep K"},{"first_name":"Jim","last_name":"Ottelé","full_name":"Ottelé, Jim"},{"full_name":"Wu, Juntian","last_name":"Wu","first_name":"Juntian"},{"full_name":"Eleveld, Marcel","last_name":"Eleveld","first_name":"Marcel"},{"last_name":"Hatai","full_name":"Hatai, Joydev","first_name":"Joydev"},{"full_name":"Pappas, Charalampos G.","last_name":"Pappas","first_name":"Charalampos G."},{"full_name":"Huc, Ivan","last_name":"Huc","first_name":"Ivan"},{"first_name":"Sijbren","full_name":"Otto, Sijbren","last_name":"Otto"}],"extern":"1","issue":"49","PlanS_conform":"1","language":[{"iso":"eng"}],"publication":"Journal of the American Chemical Society","has_accepted_license":"1","status":"public","keyword":["Fibers","Foldamers","Macrocycles","Monomers","Peptides","Proteins"],"date_created":"2026-01-08T07:06:27Z","scopus_import":"1","intvolume":"       146","pmid":1,"page":"33386-33394"}]