[{"oa_version":"Published Version","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2026-06-10T07:58:35Z","date_published":"2024-09-01T00:00:00Z","has_accepted_license":"1","file_date_updated":"2024-09-03T17:39:32Z","year":"2024","doi":"10.15479/AT:ISTA:17488","corr_author":"1","month":"09","oa":1,"ddc":["570"],"status":"public","file":[{"checksum":"df9d6c8ddffa046c3b1639281f83cfcf","access_level":"open_access","success":1,"file_size":965778072,"file_id":"17489","file_name":"BehaviouralData.zip","relation":"main_file","creator":"rsatapat","date_updated":"2024-09-03T17:39:32Z","date_created":"2024-09-03T17:39:32Z","content_type":"application/x-zip-compressed"}],"author":[{"orcid":"0009-0006-2974-5075","id":"46046B7A-F248-11E8-B48F-1D18A9856A87","first_name":"Roshan K","last_name":"Satapathy","full_name":"Satapathy, Roshan K"},{"orcid":"0000-0002-3937-1330","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","first_name":"Maximilian A","full_name":"Jösch, Maximilian A","last_name":"Jösch"},{"last_name":"Symonova","full_name":"Symonova, Olga","first_name":"Olga","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2012-9947"},{"first_name":"Victoria","full_name":"Pokusaeva, Victoria","last_name":"Pokusaeva","orcid":"0000-0001-7660-444X","id":"3184041C-F248-11E8-B48F-1D18A9856A87"}],"type":"research_data","date_created":"2024-09-03T17:42:46Z","abstract":[{"lang":"eng","text":"Behavioural data for Pokusaeva, Satapathy et al. Relevant information can be found in the 'README.txt' file."}],"user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","title":"Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies","department":[{"_id":"GradSch"},{"_id":"MaJö"}],"keyword":["drosophila","behaviour","locomotion","gap junctions"],"citation":{"apa":"Satapathy, R. K., Jösch, M. A., Symonova, O., &#38; Pokusaeva, V. (2024). Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:17488\">https://doi.org/10.15479/AT:ISTA:17488</a>","ieee":"R. K. Satapathy, M. A. Jösch, O. Symonova, and V. Pokusaeva, “Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies.” Institute of Science and Technology Austria, 2024.","short":"R.K. Satapathy, M.A. Jösch, O. Symonova, V. Pokusaeva, (2024).","ama":"Satapathy RK, Jösch MA, Symonova O, Pokusaeva V. Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies. 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:17488\">10.15479/AT:ISTA:17488</a>","chicago":"Satapathy, Roshan K, Maximilian A Jösch, Olga Symonova, and Victoria Pokusaeva. “Bilateral Interactions of Optic-Flow Sensitive Neurons Coordinate Course Control in Flies.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:17488\">https://doi.org/10.15479/AT:ISTA:17488</a>.","ista":"Satapathy RK, Jösch MA, Symonova O, Pokusaeva V. 2024. Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:17488\">10.15479/AT:ISTA:17488</a>.","mla":"Satapathy, Roshan K., et al. <i>Bilateral Interactions of Optic-Flow Sensitive Neurons Coordinate Course Control in Flies</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:17488\">10.15479/AT:ISTA:17488</a>."},"related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"18444"}]},"article_processing_charge":"No","project":[{"grant_number":"429960716","name":"Evolution of Sensorimotor Transformation Across Diptera","_id":"9B767A34-BA93-11EA-9121-9846C619BF3A"}],"acknowledged_ssus":[{"_id":"M-Shop"}],"_id":"17488","publisher":"Institute of Science and Technology Austria"},{"related_material":{"record":[{"id":"6089","status":"public","relation":"research_paper"}]},"citation":{"mla":"Fraisse, Christelle. <i>Supplementary Files for “Pleiotropy Modulates the Efficacy of Selection in Drosophila Melanogaster.”</i> Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/at:ista:/5757\">10.15479/at:ista:/5757</a>.","ieee":"C. Fraisse, “Supplementary Files for ‘Pleiotropy modulates the efficacy of selection in Drosophila melanogaster.’” Institute of Science and Technology Austria, 2018.","chicago":"Fraisse, Christelle. “Supplementary Files for ‘Pleiotropy Modulates the Efficacy of Selection in Drosophila Melanogaster.’” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/at:ista:/5757\">https://doi.org/10.15479/at:ista:/5757</a>.","ama":"Fraisse C. Supplementary Files for “Pleiotropy modulates the efficacy of selection in Drosophila melanogaster.” 2018. doi:<a href=\"https://doi.org/10.15479/at:ista:/5757\">10.15479/at:ista:/5757</a>","short":"C. Fraisse, (2018).","ista":"Fraisse C. 2018. Supplementary Files for ‘Pleiotropy modulates the efficacy of selection in Drosophila melanogaster’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/at:ista:/5757\">10.15479/at:ista:/5757</a>.","apa":"Fraisse, C. (2018). Supplementary Files for “Pleiotropy modulates the efficacy of selection in Drosophila melanogaster.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:/5757\">https://doi.org/10.15479/at:ista:/5757</a>"},"keyword":["(mal)adaptation","pleiotropy","selective constraint","evo-devo","gene expression","Drosophila melanogaster"],"department":[{"_id":"BeVi"},{"_id":"NiBa"}],"contributor":[{"id":"32DF5794-F248-11E8-B48F-1D18A9856A87","first_name":"Christelle","last_name":"Fraisse"},{"last_name":"Puixeu Sala","first_name":"Gemma","id":"33AB266C-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","last_name":"Vicoso"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Supplementary Files for \"Pleiotropy modulates the efficacy of selection in Drosophila melanogaster\"","abstract":[{"text":"File S1. Variant Calling Format file of the ingroup: 197 haploid sequences of D. melanogaster from Zambia (Africa) aligned to the D. melanogaster 5.57 reference genome.\r\n\r\nFile S2. Variant Calling Format file of the outgroup: 1 haploid sequence of D. simulans aligned to the D. melanogaster 5.57 reference genome.\r\n\r\nFile S3. Annotations of each transcript in coding regions with SNPeff: Ps (# of synonymous polymorphic sites); Pn (# of non-synonymous polymorphic sites); Ds (# of synonymous divergent sites); Dn (# of non-synonymous divergent sites); DoS; ⍺ MK . All variants were included.\r\n\r\nFile S4. Annotations of each transcript in non-coding regions with SNPeff: Ps (# of synonymous polymorphic sites); Pu (# of UTR polymorphic sites); Ds (# of synonymous divergent sites); Du (# of UTR divergent sites); DoS; ⍺ MK . All variants were included.\r\n\r\nFile S5. Annotations of each transcript in coding regions with SNPGenie: Ps (# of synonymous polymorphic sites); πs (synonymous diversity); Ss_p (total # of synonymous sites in the polymorphism data); Pn (# of non-synonymous polymorphic sites); πn (non-synonymous diversity); Sn_p (total # of non-synonymous sites in the polymorphism data); Ds (# of synonymous divergent sites); ks (synonymous evolutionary rate); Ss_d (total # of synonymous sites in the divergence data); Dn (# of non-synonymous divergent sites); kn (non-synonymous evolutionary rate); Sn_d (total # of non-\r\nsynonymous sites in the divergence data); DoS; ⍺ MK . All variants were included.\r\n\r\nFile S6. Gene expression values (RPKM summed over all transcripts) for each sample. Values were quantile-normalized across all samples.\r\n\r\nFile S7. Final dataset with all covariates, ⍺ MK , ωA MK and DoS for coding sites, excluding variants below 5% frequency.\r\n\r\nFile S8. Final dataset with all covariates, ⍺ MK , ωA MK and DoS for non-coding sites, excluding variants below 5%\r\nfrequency.\r\n\r\nFile S9. Final dataset with all covariates, ⍺ EWK , ωA EWK and deleterious SFS for coding sites obtained with the Eyre-Walker and Keightley method on binned data and using all variants.","lang":"eng"}],"date_created":"2018-12-19T14:22:35Z","type":"research_data","publisher":"Institute of Science and Technology Austria","_id":"5757","project":[{"grant_number":"291734","name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"day":"19","article_processing_charge":"No","file_date_updated":"2020-07-14T12:47:11Z","has_accepted_license":"1","date_published":"2018-12-19T00:00:00Z","date_updated":"2025-04-15T08:18:38Z","oa_version":"Published Version","author":[{"first_name":"Christelle","last_name":"Fraisse","full_name":"Fraisse, Christelle","orcid":"0000-0001-8441-5075","id":"32DF5794-F248-11E8-B48F-1D18A9856A87"}],"file":[{"file_name":"FileS1.zip","relation":"main_file","date_updated":"2020-07-14T12:47:11Z","creator":"cfraisse","date_created":"2018-12-19T14:19:52Z","content_type":"application/zip","file_size":369837892,"file_id":"5758","access_level":"open_access","checksum":"aed7ee9ca3f4dc07d8a66945f68e13cd"},{"access_level":"open_access","checksum":"3592e467b4d8206650860b612d6e12f3","file_id":"5759","file_size":84856909,"date_updated":"2020-07-14T12:47:11Z","date_created":"2018-12-19T14:19:49Z","creator":"cfraisse","content_type":"application/zip","file_name":"FileS2.zip","relation":"main_file"},{"creator":"cfraisse","date_created":"2018-12-19T14:19:49Z","date_updated":"2020-07-14T12:47:11Z","content_type":"text/plain","file_name":"FileS3.txt","relation":"main_file","access_level":"open_access","checksum":"c37ac5d5437c457338afc128c1240655","file_id":"5760","file_size":881133},{"file_name":"FileS4.txt","relation":"main_file","creator":"cfraisse","date_created":"2018-12-19T14:19:49Z","date_updated":"2020-07-14T12:47:11Z","content_type":"text/plain","file_size":883742,"file_id":"5761","checksum":"943dfd14da61817441e33e3e3cb8cdb9","access_level":"open_access"},{"checksum":"1c669b6c4690ec1bbca3e2da9f566d17","access_level":"open_access","file_size":2495437,"file_id":"5762","relation":"main_file","file_name":"FileS5.txt","date_updated":"2020-07-14T12:47:11Z","creator":"cfraisse","date_created":"2018-12-19T14:19:49Z","content_type":"text/plain"},{"checksum":"f40f661b987ca6fb6b47f650cbbb04e6","access_level":"open_access","file_size":15913457,"file_id":"5763","file_name":"FileS6.txt","relation":"main_file","date_created":"2018-12-19T14:19:50Z","date_updated":"2020-07-14T12:47:11Z","creator":"cfraisse","content_type":"text/plain"},{"file_size":2584120,"file_id":"5764","access_level":"open_access","checksum":"25f41e5b8a075669c6c88d4c6713bf6f","relation":"main_file","file_name":"FileS7.txt","date_created":"2018-12-19T14:19:50Z","creator":"cfraisse","date_updated":"2020-07-14T12:47:11Z","content_type":"text/plain"},{"checksum":"f6c0bd3e63e14ddf5445bd69b43a9152","access_level":"open_access","file_id":"5765","file_size":2446059,"date_updated":"2020-07-14T12:47:11Z","date_created":"2018-12-19T14:19:50Z","creator":"cfraisse","content_type":"text/plain","relation":"main_file","file_name":"FileS8.txt"},{"checksum":"0fe7a58a030b11bf3b9c8ff7a7addcae","access_level":"open_access","file_size":100737,"file_id":"5766","file_name":"FileS9.txt","relation":"main_file","date_updated":"2020-07-14T12:47:11Z","date_created":"2018-12-19T14:19:50Z","creator":"cfraisse","content_type":"text/plain"}],"status":"public","ec_funded":1,"ddc":["576"],"oa":1,"month":"12","doi":"10.15479/at:ista:/5757","year":"2018"},{"volume":131,"issue":"19","pmid":1,"year":"2004","intvolume":"       131","status":"public","abstract":[{"text":"Developing cells acquire positional information by reading the graded distribution of morphogens. In Drosophila, the Dpp morphogen forms a long-range concentration gradient by spreading from a restricted source in the developing wing. It has been assumed that Dpp spreads by extracellular diffusion. Under this assumption, the main role of endocytosis in gradient formation is to downregulate receptors at the cell surface. These surface receptors bind to the ligand and thereby interfere with its long-range movement. Recent experiments indicate that Dpp spreading is mediated by Dynamin-dependent endocytosis in the target tissue, suggesting that extracellular diffusion alone cannot account for Dpp dispersal. Here, we perform a theoretical study of a model for morphogen spreading based on extracellular diffusion, which takes into account receptor binding and trafficking. We compare profiles of ligand and surface receptors obtained in this model with experimental data. To this end, we monitored directly the pool of surface receptors and extracellular Dpp with specific antibodies. We conclude that current models considering pure extracellular diffusion cannot explain the observed role of endocytosis during Dpp long-range movement.","lang":"eng"}],"title":"Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model","type":"journal_article","keyword":["Drosophila","Morphogens","TGFβ"],"article_processing_charge":"No","OA_type":"closed access","page":"4843 - 4856","publist_id":"1893","_id":"4224","quality_controlled":"1","date_published":"2004-10-01T00:00:00Z","oa_version":"None","date_updated":"2026-05-29T11:09:03Z","external_id":{"pmid":["15358671"]},"month":"10","article_type":"original","doi":"10.1242/dev.01335","author":[{"first_name":"Karsten","last_name":"Kruse","full_name":"Kruse, Karsten"},{"first_name":"Periklis","full_name":"Pantazis, Periklis","last_name":"Pantazis"},{"orcid":"0000-0003-4398-476X","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","first_name":"Mark Tobias","last_name":"Bollenbach","full_name":"Bollenbach, Mark Tobias"},{"full_name":"Julicher, Frank","last_name":"Julicher","first_name":"Frank"},{"full_name":"Gonzalez Gaitan, Marcos","last_name":"Gonzalez Gaitan","first_name":"Marcos"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","extern":"1","publication":"Development","date_created":"2018-12-11T12:07:41Z","citation":{"apa":"Kruse, K., Pantazis, P., Bollenbach, M. T., Julicher, F., &#38; Gonzalez Gaitan, M. (2004). Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.01335\">https://doi.org/10.1242/dev.01335</a>","ieee":"K. Kruse, P. Pantazis, M. T. Bollenbach, F. Julicher, and M. Gonzalez Gaitan, “Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model,” <i>Development</i>, vol. 131, no. 19. Company of Biologists, pp. 4843–4856, 2004.","ama":"Kruse K, Pantazis P, Bollenbach MT, Julicher F, Gonzalez Gaitan M. Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model. <i>Development</i>. 2004;131(19):4843-4856. doi:<a href=\"https://doi.org/10.1242/dev.01335\">10.1242/dev.01335</a>","chicago":"Kruse, Karsten, Periklis Pantazis, Mark Tobias Bollenbach, Frank Julicher, and Marcos Gonzalez Gaitan. “Dpp Gradient Formation by Dynamin-Dependent Endocytosis: Receptor Trafficking and the Diffusion Model.” <i>Development</i>. Company of Biologists, 2004. <a href=\"https://doi.org/10.1242/dev.01335\">https://doi.org/10.1242/dev.01335</a>.","ista":"Kruse K, Pantazis P, Bollenbach MT, Julicher F, Gonzalez Gaitan M. 2004. Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model. Development. 131(19), 4843–4856.","short":"K. Kruse, P. Pantazis, M.T. Bollenbach, F. Julicher, M. Gonzalez Gaitan, Development 131 (2004) 4843–4856.","mla":"Kruse, Karsten, et al. “Dpp Gradient Formation by Dynamin-Dependent Endocytosis: Receptor Trafficking and the Diffusion Model.” <i>Development</i>, vol. 131, no. 19, Company of Biologists, 2004, pp. 4843–56, doi:<a href=\"https://doi.org/10.1242/dev.01335\">10.1242/dev.01335</a>."},"language":[{"iso":"eng"}],"scopus_import":"1","day":"01","publication_status":"published","publisher":"Company of Biologists"}]