@article{22956,
  abstract     = {Tissue regeneration requires de novo patterning, which has been proposed to be facilitated by cellular heterogeneity. Yet how such heterogeneities are integrated with the mechanochemical state of the tissue and stabilized at the chromatin level into stable, spatially organized fates remains poorly understood. Using in vivo mouse intestinal regeneration models and organoids, we identify a critical density regime that produces a permissive window for heterogeneity in the mechanosensor Yes-associated protein 1 (YAP1). We show that YAP1 heterogeneity is coupled to lineage-biased chromatin accessibility and is decoded through FOXA1, which integrates the permissive chromatin state to Delta-Notch supracellular feedback and lineage commitment. This circuit generates fate bistability and preserves a memory of transient YAP1 activity, thereby maintaining spatial patterning as tissues return to homeostasis after injury. Together, our findings establish a multiscale framework in which tissue-scale mechanics tune single-cell competence and, through FOXA1-mediated bistability, convert transient heterogeneity into stable and self-organized tissue architecture.},
  author       = {Schwayer, Cornelia and Barbiero, Silvia and Brückner, David and Oost, Koen C. and Baader, Clara and Repina, Nicole A. and Kim, Jinse and Diaz, Oscar E. and Uccelli, Isa and Capolupo, Laura and Meylan, Ludivine Challet and Kalck, Veronique and Moos, Franziska and Suppinger, Simon and Yang, Qiutan and Schnabl, Jakob and Kilik, Umut and Bourdon, Matthieu and Camp, J. Gray and Stockinger, Brigitta and Ferrari, Alessandra and Bühler, Marc and Stadler, Michael B. and Hannezo, Edouard B and Liberali, Prisca},
  issn         = {1097-4172},
  journal      = {Cell},
  keywords     = {tissue patterning, heterogeneity, mechanics, intestinal regeneration, epigenetic competence, multiscale integration, modeling, organoids, image-based phenotyping, Yap1},
  number       = {17},
  pages        = {5266--5282.e17},
  publisher    = {Cell Press},
  title        = {{Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning}},
  doi          = {10.1016/j.cell.2026.06.009},
  volume       = {189},
  year         = {2026},
}

@article{22510,
  abstract     = {This study advances mechanistic interpretation of predictability challenges in hydro-geomorphology related to the role of soil moisture spatial variability. Using model formulations describing the physics of overland flow, variably saturated subsurface flow, and erosion and sediment transport, this study explores (1) why a basin with the same mean soil moisture can exhibit distinctly different spatial moisture distributions, (2) whether these varying distributions lead to non-unique hydro-geomorphic responses, and (3) what controls non-uniqueness in relation to the response type. Two sets of numerical experiments are carried out with two physically-based models, HYDRUS and tRIBS+VEGGIE+FEaST, and their outputs are analyzed with respect to pre-storm moisture state. The results demonstrate that distinct spatial moisture distributions for the same mean wetness arise because near-surface soil moisture dynamics exhibit different degrees of coupling with deeper-soil moisture and the process of subsurface drainage. The consequences of such variations are different depending on the type of hydrological response. Specifically, if the predominant runoff response is of infiltration excess type, the degree of non-uniqueness is related to the spatial distribution of near-surface moisture. If runoff is governed by subsurface stormflow, the extent of deep moisture contributing area and its “readiness to drain” determine the response characteristics. Because the processes of erosion and sediment transport superimpose additional controls over factors governing runoff generation and overland flow, non-uniqueness of the geomorphic response can be highly dampened or enhanced. The explanation is sediment composed by multi-size particles can alternate states of mobilization or surface shielding and the transient behavior is inherently intertwined with the availability of mobile particles. We conclude that complex nonlinear dynamics of hydro-geomorphic processes are inherent expressions of physical interactions. As complete knowledge of watershed properties, states, or forcings will always present the ultimate, if ever resolvable, challenge, deterministic predictability will remain handicapped. Coupling of uncertainty quantification methods and space-time physics-based approaches will need to evolve to facilitate mechanistic interpretations and informed practical applications.},
  author       = {Kim, Jongho and Dwelle, M. Chase and Kampf, Stephanie K. and Fatichi, Simone and Ivanov, Valeriy Y.},
  issn         = {0309-1708},
  journal      = {Advances in Water Resources},
  keywords     = {Soil moisture, Spatial heterogeneity, Hydrological response, Geomorphic response, Non-uniqueness, Hydraulic connectivity},
  pages        = {73--89},
  publisher    = {Elsevier},
  title        = {{On the non-uniqueness of the hydro-geomorphic responses in a zero-order catchment with respect to soil moisture}},
  doi          = {10.1016/j.advwatres.2016.03.019},
  volume       = {92},
  year         = {2016},
}