---
_id: '21442'
author:
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
citation:
ama: Schlögl A. CA3Simu v1.06 (vargas2026v1). 2026. doi:10.15479/AT-ISTA-21442
apa: Schlögl, A. (2026). CA3Simu v1.06 (vargas2026v1). Institute of Science and
Technology Austria. https://doi.org/10.15479/AT-ISTA-21442
chicago: Schlögl, Alois. “CA3Simu v1.06 (Vargas2026v1).” Institute of Science and
Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21442.
ieee: A. Schlögl, “CA3Simu v1.06 (vargas2026v1).” Institute of Science and Technology
Austria, 2026.
ista: Schlögl A. 2026. CA3Simu v1.06 (vargas2026v1), Institute of Science and Technology
Austria, 10.15479/AT-ISTA-21442.
mla: Schlögl, Alois. CA3Simu v1.06 (Vargas2026v1). Institute of Science and
Technology Austria, 2026, doi:10.15479/AT-ISTA-21442.
short: A. Schlögl, (2026).
corr_author: '1'
date_created: 2026-03-12T08:20:46Z
date_published: 2026-03-12T00:00:00Z
date_updated: 2026-07-01T06:47:49Z
day: '12'
department:
- _id: ScienComp
- _id: PeJo
doi: 10.15479/AT-ISTA-21442
ec_funded: 1
file:
- access_level: open_access
checksum: 441c8827717dcda05f91c127d15cf1e9
content_type: application/gzip
creator: schloegl
date_created: 2026-03-12T08:19:14Z
date_updated: 2026-03-12T08:19:14Z
file_id: '21443'
file_name: ca3simu-vargas2026v1.tar.gz
file_size: 160410
relation: main_file
success: 1
- access_level: open_access
checksum: 3c0092076228a15c0a7ae703192d43ea
content_type: text/markdown
creator: schloegl
date_created: 2026-03-12T10:24:45Z
date_updated: 2026-03-12T10:24:45Z
file_id: '21445'
file_name: README.md
file_size: 10923
relation: main_file
success: 1
file_date_updated: 2026-03-12T10:24:45Z
fulldoi: https://doi.org/10.15479/AT-ISTA-21442
has_accepted_license: '1'
keyword:
- hypocampus
- ca3 simulations
- modelling
license: https://opensource.org/licenses/GPL-3.0
month: '03'
oa: 1
project:
- _id: e62b56fe-ab3c-11f0-94c7-d181dd352b3b
grant_number: '101199096'
name: Synaptic mechanisms of engram storage and retrieval in CA3 hippocampal microcircuits
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
grant_number: P36232
name: Mechanisms of GABA release in hippocampal circuits
- _id: 8d9195e9-16d5-11f0-9cad-d075be887a1e
grant_number: PAT 4178023
name: Synaptic networks of human brain
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glutamatergic synapse
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '22229'
relation: used_in_publication
status: public
status: public
title: CA3Simu v1.06 (vargas2026v1)
tmp:
legal_code_url: https://www.gnu.org/licenses/gpl-3.0.en.html
name: GNU General Public License 3.0
short: GPL 3.0
type: software
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '22298'
abstract:
- lang: eng
text: Air traffic management is a critical component of aviation, aiming to balance
safety, capacity and demand within controlled airspace. This research analyses
Iran's domestic air transport network (2018-2021) by developing annual Origin-Destination
(OD) impedance matrices based on flight frequency. The methodology quantifies
network connectivity, revealing a highly centralized structure dominated by core
corridors like Tehran-Mashhad, which carried over 10,500 flights in 2019. The
COVID-19 pandemic caused a severe disruption in 2020, with traffic on major routes
falling by nearly half, followed by a partial recovery in 2021. Analysis shows
core hubs rebounded faster than peripheral airports, widening accessibility gaps.
Through origin-destination matrix processing, the system identifies high density
air routes and analyses historical trends in airspace utilization. The impedance
matrix, validated against data (R²=0.87), successfully maps the intense service
on hub links and the high impedance of sparse peripheral routes. Then an interactive
Web GIS platform was implemented for spatiotemporal analysis of air traffic density.
acknowledgement: "We sincerely thank the Iranian Airports and Air Navigation\r\nCompany
for sharing statistical data on flights from Iranian\r\nairports, separated by origin
and destination, for this research."
article_processing_charge: No
author:
- first_name: Masoumeh
full_name: Eghbali Mardekheh, Masoumeh
last_name: Eghbali Mardekheh
- first_name: Meysam
full_name: Argany, Meysam
last_name: Argany
- first_name: Farid
full_name: Karimipour, Farid
id: 2A2BCDC4-CF62-11E9-BE5E-3B1EE6697425
last_name: Karimipour
orcid: 0000-0001-6746-4174
- first_name: Seyed Mohammad
full_name: Sedghitabar, Seyed Mohammad
last_name: Sedghitabar
citation:
ama: 'Eghbali Mardekheh M, Argany M, Karimipour F, Sedghitabar SM. Real time interactive
web GIS based modelling of high traffic air corridors in Iran using origin destination
matrix analysis. In: 8th ISPRS Geospatial Conference. Vol X. Copernicus
Publications; 2026:493-500. doi:10.5194/isprs-annals-x-4-w8-2025-493-2026'
apa: 'Eghbali Mardekheh, M., Argany, M., Karimipour, F., & Sedghitabar, S. M.
(2026). Real time interactive web GIS based modelling of high traffic air corridors
in Iran using origin destination matrix analysis. In 8th ISPRS Geospatial Conference
(Vol. X, pp. 493–500). Tehran, Iran: Copernicus Publications. https://doi.org/10.5194/isprs-annals-x-4-w8-2025-493-2026'
chicago: Eghbali Mardekheh, Masoumeh, Meysam Argany, Farid Karimipour, and Seyed
Mohammad Sedghitabar. “Real Time Interactive Web GIS Based Modelling of High Traffic
Air Corridors in Iran Using Origin Destination Matrix Analysis.” In 8th ISPRS
Geospatial Conference, X:493–500. Copernicus Publications, 2026. https://doi.org/10.5194/isprs-annals-x-4-w8-2025-493-2026.
ieee: M. Eghbali Mardekheh, M. Argany, F. Karimipour, and S. M. Sedghitabar, “Real
time interactive web GIS based modelling of high traffic air corridors in Iran
using origin destination matrix analysis,” in 8th ISPRS Geospatial Conference,
Tehran, Iran, 2026, vol. X, no. 4/W8-2025, pp. 493–500.
ista: 'Eghbali Mardekheh M, Argany M, Karimipour F, Sedghitabar SM. 2026. Real time
interactive web GIS based modelling of high traffic air corridors in Iran using
origin destination matrix analysis. 8th ISPRS Geospatial Conference. ISPRS: Conference
on Photogrammetry, Remote Sensing and Spatial Information Sciences, vol. X, 493–500.'
mla: Eghbali Mardekheh, Masoumeh, et al. “Real Time Interactive Web GIS Based Modelling
of High Traffic Air Corridors in Iran Using Origin Destination Matrix Analysis.”
8th ISPRS Geospatial Conference, vol. X, no. 4/W8-2025, Copernicus Publications,
2026, pp. 493–500, doi:10.5194/isprs-annals-x-4-w8-2025-493-2026.
short: M. Eghbali Mardekheh, M. Argany, F. Karimipour, S.M. Sedghitabar, in:, 8th
ISPRS Geospatial Conference, Copernicus Publications, 2026, pp. 493–500.
conference:
end_date: 2025-12-17
location: Tehran, Iran
name: 'ISPRS: Conference on Photogrammetry, Remote Sensing and Spatial Information
Sciences,'
start_date: 2025-12-15
das_tickbox: '0'
date_created: 2026-07-13T09:51:29Z
date_published: 2026-05-29T00:00:00Z
date_updated: 2026-07-14T05:56:30Z
day: '29'
ddc:
- '500'
department:
- _id: HeEd
doi: 10.5194/isprs-annals-x-4-w8-2025-493-2026
file:
- access_level: open_access
checksum: 7c088dd179cfee6074a350c95671dbe3
content_type: application/pdf
creator: dernst
date_created: 2026-07-14T05:55:34Z
date_updated: 2026-07-14T05:55:34Z
file_id: '22328'
file_name: 2026_ISPRS_EghbaliMardekheh.pdf
file_size: 2697680
relation: main_file
success: 1
file_date_updated: 2026-07-14T05:55:34Z
fulldoi: https://doi.org/10.5194/isprs-annals-x-4-w8-2025-493-2026
has_accepted_license: '1'
issue: -4/W8-2025
keyword:
- Air Traffic simulation
- Dynamic Air Traffic Corridors
- Origin Destination matrix
- Interactive Web GIS
- Iran Aviation Network
- Spatiotemporal Modelling
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 493-500
publication: 8th ISPRS Geospatial Conference
publication_identifier:
issn:
- 2194-9050
publication_status: published
publisher: Copernicus Publications
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Real time interactive web GIS based modelling of high traffic air corridors
in Iran using origin destination matrix analysis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: X
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '20655'
abstract:
- lang: eng
text: Traits that affect organismal fitness are often highly genetically variable.
This genetic variation is vital for populations to adapt to their environments,
but it is also surprising given that nature – after all – ‘selects’ the best genotypes
at the expense of those that fall short. Explaining the extensive genetic variation
of fitness‐related traits is thus a longstanding puzzle in evolutionary biology,
with cascading implications for ecology, conservation, and human health. Balancing
selection – an umbrella term for scenarios in which natural selection maintains
genetic variation – is a century‐old explanation to resolve this puzzle that has
gained recent momentum from genome‐scale methods for detecting it. Yet evaluating
whether balancing selection can, in fact, resolve the puzzle is challenging, given
the logistical constraints of distinguishing balancing selection from alternative
hypotheses and the daunting collection of theoretical models that formally underpin
this debate. Here, we track the development of balancing selection theory over
the last century and provide an accessible review of this rich collection of models.
We first outline the range of biological scenarios that can generate balancing
selection. We then examine how fundamental features of genetic systems – non‐random
mating between individuals, ploidy levels, genetic drift, linkage, and genetic
architectures of traits – have been progressively incorporated into the theory.
We end by linking these theoretical predictions to ongoing empirical efforts to
understand the evolutionary processes that explain genetic variation.
acknowledgement: 'We thank Brian Charlesworth, Deborah Charlesworth, and Sally Otto
for extensive comments and suggestions. We also thank Göran Arnqvist, Adam Eyre-Walker,
Philip Hedrick, Jitka Polechová, and Henrique Teotónio for further helpful comments
on the manuscript. This work was supported by a H2020 Marie Skłodowska-Curie COFUND
Action fellowship (#101034413, to F. R.), the Birgitta Sintring Foundation (#S2024-0007,
to M. K. Z.), the Research Council of Norway (302619, to D. G.), the Alexander von
Humboldt Foundation (to H. K.), the Swiss National Science Foundation (#211549,
to X. L. R.), the Swedish Research Council (#2022-03603, to CO; #2020-03123, to
E. I. S.) and the European Research Council (ERC-2023-STG-#101117517, to C. O.).
We are particularly grateful to the European Society for Evolutionary Biology for
funding a Special Topics Network workshop (to T. C., H. K., E. I. S.), from which
this review began. Open Access funding provided by Institute of Science and Technology
Austria/KEMÖ.'
article_number: 804-825
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Filip
full_name: Ruzicka, Filip
id: 347955dd-57b0-11ee-9095-c28bdd368f4b
last_name: Ruzicka
- first_name: Martyna K.
full_name: Zwoinska, Martyna K.
last_name: Zwoinska
- first_name: Debora
full_name: Goedert, Debora
last_name: Goedert
- first_name: Hanna
full_name: Kokko, Hanna
last_name: Kokko
- first_name: Xiang‐Yi
full_name: Li Richter, Xiang‐Yi
last_name: Li Richter
- first_name: Iain R.
full_name: Moodie, Iain R.
last_name: Moodie
- first_name: Sofie
full_name: Nilén, Sofie
last_name: Nilén
- first_name: Colin
full_name: Olito, Colin
last_name: Olito
- first_name: Erik I.
full_name: Svensson, Erik I.
last_name: Svensson
- first_name: Peter
full_name: Czuppon, Peter
last_name: Czuppon
- first_name: Tim
full_name: Connallon, Tim
last_name: Connallon
citation:
ama: Ruzicka F, Zwoinska MK, Goedert D, et al. A century of theories of balancing
selection. Biological Reviews. 2026;101(2). doi:10.1111/brv.70103
apa: Ruzicka, F., Zwoinska, M. K., Goedert, D., Kokko, H., Li Richter, X., Moodie,
I. R., … Connallon, T. (2026). A century of theories of balancing selection. Biological
Reviews. Wiley. https://doi.org/10.1111/brv.70103
chicago: Ruzicka, Filip, Martyna K. Zwoinska, Debora Goedert, Hanna Kokko, Xiang‐Yi
Li Richter, Iain R. Moodie, Sofie Nilén, et al. “A Century of Theories of Balancing
Selection.” Biological Reviews. Wiley, 2026. https://doi.org/10.1111/brv.70103.
ieee: F. Ruzicka et al., “A century of theories of balancing selection,”
Biological Reviews, vol. 101, no. 2. Wiley, 2026.
ista: Ruzicka F, Zwoinska MK, Goedert D, Kokko H, Li Richter X, Moodie IR, Nilén
S, Olito C, Svensson EI, Czuppon P, Connallon T. 2026. A century of theories of
balancing selection. Biological Reviews. 101(2), 804–825.
mla: Ruzicka, Filip, et al. “A Century of Theories of Balancing Selection.” Biological
Reviews, vol. 101, no. 2, 804–825, Wiley, 2026, doi:10.1111/brv.70103.
short: F. Ruzicka, M.K. Zwoinska, D. Goedert, H. Kokko, X. Li Richter, I.R. Moodie,
S. Nilén, C. Olito, E.I. Svensson, P. Czuppon, T. Connallon, Biological Reviews
101 (2026).
corr_author: '1'
das_tickbox: '0'
date_created: 2025-11-19T09:43:50Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-07-27T08:08:09Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1111/brv.70103
ec_funded: 1
external_id:
isi:
- '001614285900001'
pmid:
- '41235821 '
file:
- access_level: open_access
checksum: 167d95cf0570d6e3653ab349b2a4355c
content_type: application/pdf
creator: dernst
date_created: 2026-07-27T08:07:35Z
date_updated: 2026-07-27T08:07:35Z
file_id: '22409'
file_name: 2026_BiologicalReviews_Ruzicka.pdf
file_size: 1757556
relation: main_file
success: 1
file_date_updated: 2026-07-27T08:07:35Z
fulldoi: https://doi.org/10.1111/brv.70103
has_accepted_license: '1'
intvolume: ' 101'
isi: 1
issue: '2'
keyword:
- evolutionary theory
- population genetics
- balancing selection
- heterozygote advantage
- trade-offs
- negative frequency-dependent selection
- fitness variation
- mathematical modelling
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Biological Reviews
publication_identifier:
eissn:
- 1469-185X
issn:
- 1464-7931
publication_status: published
publisher: Wiley
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: A century of theories of balancing selection
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 101
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '22513'
abstract:
- lang: eng
text: High elevation headwater catchments are complex hydrological systems that
seasonally buffer water and release it in the form of snow and ice melt, modulating
downstream runoff regimes and water availability. In High Mountain Asia (HMA),
where a wide range of climates from semi-arid to monsoonal exist, the importance
of the cryospheric contributions to the water budget varies with the amount and
seasonal distribution of precipitation. Losses due to evapotranspiration and sublimation
are to date largely unquantified components of the water budget in such catchments,
although they can be comparable in magnitude to glacier melt contributions to
streamflow. Here, we simulate the hydrology of three high elevation headwater
catchments in distinct climates in HMA over 10 years using an ecohydrological
model geared towards high-mountain areas including snow and glaciers, forced with
reanalysis data. Our results show that evapotranspiration and sublimation together
are most important at the semi-arid site, Kyzylsu, on the northernmost slopes
of the Pamir mountain range. Here, the evaporative loss amounts to 28% of the
water throughput, which we define as the total water added to, or removed from
the water balance within a year. In comparison, evaporative losses are 19% at
the Central Himalayan site Langtang and 13% at the wettest site, 24 K, on the
Southeastern Tibetan Plateau. At the three sites, respectively, sublimation removes
15%, 13% and 6% of snowfall, while evapotranspiration removes the equivalent of
76%, 28% and 19% of rainfall. In absolute terms, and across a comparable elevation
range, the highest ET flux is 413 mm yr−1 at 24 K, while the highest sublimation
flux is 91 mm yr−1 at Kyzylsu. During warm and dry years, glacier melt was found
to only partially compensate for the annual supply deficit.
article_number: '044057'
article_processing_charge: No
article_type: letter_note
author:
- first_name: S
full_name: Fugger, S
last_name: Fugger
- first_name: T E
full_name: Shaw, T E
last_name: Shaw
- first_name: A
full_name: Jouberton, A
last_name: Jouberton
- first_name: E S
full_name: Miles, E S
last_name: Miles
- first_name: P
full_name: Buri, P
last_name: Buri
- first_name: M
full_name: McCarthy, M
last_name: McCarthy
- first_name: C
full_name: Fyffe, C
last_name: Fyffe
- first_name: Simone
full_name: Fatichi, Simone
id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
last_name: Fatichi
- first_name: M
full_name: Kneib, M
last_name: Kneib
- first_name: Peter
full_name: Molnar, Peter
last_name: Molnar
- first_name: F
full_name: Pellicciotti, F
last_name: Pellicciotti
citation:
ama: Fugger S, Shaw TE, Jouberton A, et al. Hydrological regimes and evaporative
flux partitioning at the climatic ends of high mountain Asia. Environmental
Research Letters. 2024;19(4). doi:10.1088/1748-9326/ad25a0
apa: Fugger, S., Shaw, T. E., Jouberton, A., Miles, E. S., Buri, P., McCarthy, M.,
… Pellicciotti, F. (2024). Hydrological regimes and evaporative flux partitioning
at the climatic ends of high mountain Asia. Environmental Research Letters.
IOP Publishing. https://doi.org/10.1088/1748-9326/ad25a0
chicago: Fugger, S, T E Shaw, A Jouberton, E S Miles, P Buri, M McCarthy, C Fyffe,
et al. “Hydrological Regimes and Evaporative Flux Partitioning at the Climatic
Ends of High Mountain Asia.” Environmental Research Letters. IOP Publishing,
2024. https://doi.org/10.1088/1748-9326/ad25a0.
ieee: S. Fugger et al., “Hydrological regimes and evaporative flux partitioning
at the climatic ends of high mountain Asia,” Environmental Research Letters,
vol. 19, no. 4. IOP Publishing, 2024.
ista: Fugger S, Shaw TE, Jouberton A, Miles ES, Buri P, McCarthy M, Fyffe C, Fatichi
S, Kneib M, Molnar P, Pellicciotti F. 2024. Hydrological regimes and evaporative
flux partitioning at the climatic ends of high mountain Asia. Environmental Research
Letters. 19(4), 044057.
mla: Fugger, S., et al. “Hydrological Regimes and Evaporative Flux Partitioning
at the Climatic Ends of High Mountain Asia.” Environmental Research Letters,
vol. 19, no. 4, 044057, IOP Publishing, 2024, doi:10.1088/1748-9326/ad25a0.
short: S. Fugger, T.E. Shaw, A. Jouberton, E.S. Miles, P. Buri, M. McCarthy, C.
Fyffe, S. Fatichi, M. Kneib, P. Molnar, F. Pellicciotti, Environmental Research
Letters 19 (2024).
das_tickbox: '1'
date_created: 2026-07-27T12:30:24Z
date_published: 2024-04-09T00:00:00Z
date_updated: 2026-08-07T11:03:46Z
day: '09'
doi: 10.1088/1748-9326/ad25a0
extern: '1'
fulldoi: https://doi.org/10.1088/1748-9326/ad25a0
intvolume: ' 19'
issue: '4'
keyword:
- Glacio-hydrology
- High mountain Asia
- High mountain hydrology
- Ecohydrology
- Landsurface modelling
- Remote sensing hydrology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1088/1748-9326/ad25a0
month: '04'
oa: 1
oa_version: Published Version
publication: Environmental Research Letters
publication_identifier:
eissn:
- 1748-9326
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hydrological regimes and evaporative flux partitioning at the climatic ends
of high mountain Asia
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 19
year: '2024'
...
---
_id: '8997'
abstract:
- lang: eng
text: Phenomenological relations such as Ohm’s or Fourier’s law have a venerable
history in physics but are still scarce in biology. This situation restrains predictive
theory. Here, we build on bacterial “growth laws,” which capture physiological
feedback between translation and cell growth, to construct a minimal biophysical
model for the combined action of ribosome-targeting antibiotics. Our model predicts
drug interactions like antagonism or synergy solely from responses to individual
drugs. We provide analytical results for limiting cases, which agree well with
numerical results. We systematically refine the model by including direct physical
interactions of different antibiotics on the ribosome. In a limiting case, our
model provides a mechanistic underpinning for recent predictions of higher-order
interactions that were derived using entropy maximization. We further refine the
model to include the effects of antibiotics that mimic starvation and the presence
of resistance genes. We describe the impact of a starvation-mimicking antibiotic
on drug interactions analytically and verify it experimentally. Our extended model
suggests a change in the type of drug interaction that depends on the strength
of resistance, which challenges established rescaling paradigms. We experimentally
show that the presence of unregulated resistance genes can lead to altered drug
interaction, which agrees with the prediction of the model. While minimal, the
model is readily adaptable and opens the door to predicting interactions of second
and higher-order in a broad range of biological systems.
acknowledgement: 'This work was supported in part by Tum stipend of Knafelj foundation
(to B.K.), Austrian Science Fund (FWF) standalone grants P 27201-B22 (to T.B.) and
P 28844(to G.T.), HFSP program Grant RGP0042/2013 (to T.B.), German Research Foundation
(DFG) individual grant BO 3502/2-1 (to T.B.), and German Research Foundation (DFG)
Collaborative Research Centre (SFB) 1310 (to T.B.). '
article_number: e1008529
article_processing_charge: Yes
article_type: original
author:
- first_name: Bor
full_name: Kavcic, Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Tobias
full_name: Bollenbach, Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
citation:
ama: Kavcic B, Tkačik G, Bollenbach MT. Minimal biophysical model of combined antibiotic
action. PLOS Computational Biology. 2021;17. doi:10.1371/journal.pcbi.1008529
apa: Kavcic, B., Tkačik, G., & Bollenbach, M. T. (2021). Minimal biophysical
model of combined antibiotic action. PLOS Computational Biology. Public
Library of Science. https://doi.org/10.1371/journal.pcbi.1008529
chicago: Kavcic, Bor, Gašper Tkačik, and Mark Tobias Bollenbach. “Minimal Biophysical
Model of Combined Antibiotic Action.” PLOS Computational Biology. Public
Library of Science, 2021. https://doi.org/10.1371/journal.pcbi.1008529.
ieee: B. Kavcic, G. Tkačik, and M. T. Bollenbach, “Minimal biophysical model of
combined antibiotic action,” PLOS Computational Biology, vol. 17. Public
Library of Science, 2021.
ista: Kavcic B, Tkačik G, Bollenbach MT. 2021. Minimal biophysical model of combined
antibiotic action. PLOS Computational Biology. 17, e1008529.
mla: Kavcic, Bor, et al. “Minimal Biophysical Model of Combined Antibiotic Action.”
PLOS Computational Biology, vol. 17, e1008529, Public Library of Science,
2021, doi:10.1371/journal.pcbi.1008529.
short: B. Kavcic, G. Tkačik, M.T. Bollenbach, PLOS Computational Biology 17 (2021).
date_created: 2021-01-08T07:16:18Z
date_published: 2021-01-07T00:00:00Z
date_updated: 2026-07-06T12:44:35Z
day: '07'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1371/journal.pcbi.1008529
external_id:
isi:
- '000608045000010'
pmid:
- '33411759'
file:
- access_level: open_access
checksum: e29f2b42651bef8e034781de8781ffac
content_type: application/pdf
creator: dernst
date_created: 2021-02-04T12:30:48Z
date_updated: 2021-02-04T12:30:48Z
file_id: '9092'
file_name: 2021_PlosComBio_Kavcic.pdf
file_size: 3690053
relation: main_file
success: 1
file_date_updated: 2021-02-04T12:30:48Z
fulldoi: https://doi.org/10.1371/journal.pcbi.1008529
has_accepted_license: '1'
intvolume: ' 17'
isi: 1
keyword:
- Modelling and Simulation
- Genetics
- Molecular Biology
- Antibiotics
- Drug interactions
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25E9AF9E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P27201-B22
name: Revealing the mechanisms underlying drug interactions
- _id: 254E9036-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28844-B27
name: Biophysics of information processing in gene regulation
publication: PLOS Computational Biology
publication_identifier:
issn:
- 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
record:
- id: '8930'
relation: research_data
status: public
- id: '7673'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Minimal biophysical model of combined antibiotic action
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2021'
...
---
_id: '9387'
abstract:
- lang: eng
text: We report the complete analysis of a deterministic model of deleterious mutations
and negative selection against them at two haploid loci without recombination.
As long as mutation is a weaker force than selection, mutant alleles remain rare
at the only stable equilibrium, and otherwise, a variety of dynamics are possible.
If the mutation-free genotype is absent, generally the only stable equilibrium
is the one that corresponds to fixation of the mutant allele at the locus where
it is less deleterious. This result suggests that fixation of a deleterious allele
that follows a click of the Muller’s ratchet is governed by natural selection,
instead of random drift.
acknowledgement: This work was supported by the Russian Science Foundation grant N
16-14-10173.
article_number: '110729'
article_processing_charge: No
article_type: original
author:
- first_name: Kseniia
full_name: Khudiakova, Kseniia
id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
last_name: Khudiakova
orcid: 0000-0002-6246-1465
- first_name: Tatiana Yu.
full_name: Neretina, Tatiana Yu.
last_name: Neretina
- first_name: Alexey S.
full_name: Kondrashov, Alexey S.
last_name: Kondrashov
citation:
ama: Khudiakova K, Neretina TY, Kondrashov AS. Two linked loci under mutation-selection
balance and Muller’s ratchet. Journal of Theoretical Biology. 2021;524.
doi:10.1016/j.jtbi.2021.110729
apa: Khudiakova, K., Neretina, T. Y., & Kondrashov, A. S. (2021). Two linked
loci under mutation-selection balance and Muller’s ratchet. Journal of Theoretical
Biology. Elsevier. https://doi.org/10.1016/j.jtbi.2021.110729
chicago: Khudiakova, Kseniia, Tatiana Yu. Neretina, and Alexey S. Kondrashov. “Two
Linked Loci under Mutation-Selection Balance and Muller’s Ratchet.” Journal
of Theoretical Biology. Elsevier, 2021. https://doi.org/10.1016/j.jtbi.2021.110729.
ieee: K. Khudiakova, T. Y. Neretina, and A. S. Kondrashov, “Two linked loci under
mutation-selection balance and Muller’s ratchet,” Journal of Theoretical Biology,
vol. 524. Elsevier, 2021.
ista: Khudiakova K, Neretina TY, Kondrashov AS. 2021. Two linked loci under mutation-selection
balance and Muller’s ratchet. Journal of Theoretical Biology. 524, 110729.
mla: Khudiakova, Kseniia, et al. “Two Linked Loci under Mutation-Selection Balance
and Muller’s Ratchet.” Journal of Theoretical Biology, vol. 524, 110729,
Elsevier, 2021, doi:10.1016/j.jtbi.2021.110729.
short: K. Khudiakova, T.Y. Neretina, A.S. Kondrashov, Journal of Theoretical Biology
524 (2021).
das_tickbox: '1'
date_created: 2021-05-12T05:58:42Z
date_published: 2021-04-24T00:00:00Z
date_updated: 2026-07-06T12:58:31Z
day: '24'
department:
- _id: GradSch
doi: 10.1016/j.jtbi.2021.110729
external_id:
isi:
- '000659161500002'
pmid:
- '33901507'
fulldoi: https://doi.org/10.1016/j.jtbi.2021.110729
intvolume: ' 524'
isi: 1
keyword:
- General Biochemistry
- Genetics and Molecular Biology
- Modelling and Simulation
- Statistics and Probability
- General Immunology and Microbiology
- Applied Mathematics
- General Agricultural and Biological Sciences
- General Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/477489v1
month: '04'
oa: 1
oa_version: Preprint
pmid: 1
publication: Journal of Theoretical Biology
publication_identifier:
issn:
- 0022-5193
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Two linked loci under mutation-selection balance and Muller’s ratchet
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 524
year: '2021'
...
---
OA_place: publisher
OA_type: hybrid
_id: '22529'
abstract:
- lang: eng
text: Mountainous catchments cover a broad range of elevations and their response
to a warming climate is expected to vary significantly in space. Nevertheless,
studies on climate change impacts typically examine the changes in flow statistics
only at the catchment outlet. In this study, we instead demonstrate the high variability
of the hydrological response to climate change at the sub-catchment scale, investigating
in detail the contribution of all components of the hydrological cycle in two
mountainous catchments (Thur and Kleine Emme) in the Swiss Alps. The analysis
was conducted with a two-dimensional weather generator model that simulated gridded
climate variables at an hourly and 2-km resolution until the end of the 21st century
for the RCP8.5 emission scenario. The climate ensemble was used as input into
a distributed hydrological model to estimate the changes in hydrological processes
at 100-m and hourly resolutions. Climate models show that precipitation intensifies
during winter but weakens during summer in the order of ± 5–10% toward the end
of the century. Temperature will rise by up to 4°C, leading to a 50% reduction
in snowmelt, 10% increase in evapotranspiration, and shift in precipitation type
from snowfall to rainfall. As a result, streamflow is projected to increase by
40% in winter but decrease by 20% to 40% during summer, with winter floods becoming
more frequent. The changes to streamflow (mean and extreme low and high flows)
at the sub-catchments show a strong dependency with elevation. In contrast to
the small changes projected at the outlet of the catchments, streamflow shows
a reduction at higher elevations (up to −20% change in mean streamflow for sub-catchments
at elevations exceeding 1400 m) and an increase at lower elevations (up to +5%
for Kleine Emme and +20% for the Thur at elevations below 600 m). These impacts
are tied to the changes in precipitation, as well as changes in snowmelt (at high
elevation) and evapotranspiration (at low elevation). The results reveal the causes
and diversity of hydrological response to climate change, emphasizing the importance
of investigating the distributed impacts of climate change in mountainous environments.
article_number: '126806'
article_processing_charge: No
article_type: original
author:
- first_name: Jorge Sebastián
full_name: Moraga, Jorge Sebastián
last_name: Moraga
- first_name: Nadav
full_name: Peleg, Nadav
last_name: Peleg
- first_name: Simone
full_name: Fatichi, Simone
id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
last_name: Fatichi
- first_name: Peter
full_name: Molnar, Peter
last_name: Molnar
- first_name: Paolo
full_name: Burlando, Paolo
last_name: Burlando
citation:
ama: Moraga JS, Peleg N, Fatichi S, Molnar P, Burlando P. Revealing the impacts
of climate change on mountainous catchments through high-resolution modelling.
Journal of Hydrology. 2021;603. doi:10.1016/j.jhydrol.2021.126806
apa: Moraga, J. S., Peleg, N., Fatichi, S., Molnar, P., & Burlando, P. (2021).
Revealing the impacts of climate change on mountainous catchments through high-resolution
modelling. Journal of Hydrology. Elsevier. https://doi.org/10.1016/j.jhydrol.2021.126806
chicago: Moraga, Jorge Sebastián, Nadav Peleg, Simone Fatichi, Peter Molnar, and
Paolo Burlando. “Revealing the Impacts of Climate Change on Mountainous Catchments
through High-Resolution Modelling.” Journal of Hydrology. Elsevier, 2021.
https://doi.org/10.1016/j.jhydrol.2021.126806.
ieee: J. S. Moraga, N. Peleg, S. Fatichi, P. Molnar, and P. Burlando, “Revealing
the impacts of climate change on mountainous catchments through high-resolution
modelling,” Journal of Hydrology, vol. 603. Elsevier, 2021.
ista: Moraga JS, Peleg N, Fatichi S, Molnar P, Burlando P. 2021. Revealing the impacts
of climate change on mountainous catchments through high-resolution modelling.
Journal of Hydrology. 603, 126806.
mla: Moraga, Jorge Sebastián, et al. “Revealing the Impacts of Climate Change on
Mountainous Catchments through High-Resolution Modelling.” Journal of Hydrology,
vol. 603, 126806, Elsevier, 2021, doi:10.1016/j.jhydrol.2021.126806.
short: J.S. Moraga, N. Peleg, S. Fatichi, P. Molnar, P. Burlando, Journal of Hydrology
603 (2021).
das_tickbox: '1'
date_created: 2026-07-27T12:30:24Z
date_published: 2021-12-01T00:00:00Z
date_updated: 2026-08-06T14:31:25Z
day: '01'
doi: 10.1016/j.jhydrol.2021.126806
extern: '1'
fulldoi: https://doi.org/10.1016/j.jhydrol.2021.126806
intvolume: ' 603'
keyword:
- Catchment modelling
- Climate change impacts
- Weather generator
- Distributed hydrological model
- Streamflow extremes
- Hydrological response
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.jhydrol.2021.126806
month: '12'
oa: 1
oa_version: Published Version
publication: Journal of Hydrology
publication_identifier:
eissn:
- 1879-2707
issn:
- 0022-1694
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Revealing the impacts of climate change on mountainous catchments through high-resolution
modelling
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 603
year: '2021'
...
---
_id: '8767'
abstract:
- lang: eng
text: Resources are rarely distributed uniformly within a population. Heterogeneity
in the concentration of a drug, the quality of breeding sites, or wealth can all
affect evolutionary dynamics. In this study, we represent a collection of properties
affecting the fitness at a given location using a color. A green node is rich
in resources while a red node is poorer. More colors can represent a broader spectrum
of resource qualities. For a population evolving according to the birth-death
Moran model, the first question we address is which structures, identified by
graph connectivity and graph coloring, are evolutionarily equivalent. We prove
that all properly two-colored, undirected, regular graphs are evolutionarily equivalent
(where “properly colored” means that no two neighbors have the same color). We
then compare the effects of background heterogeneity on properly two-colored graphs
to those with alternative schemes in which the colors are permuted. Finally, we
discuss dynamic coloring as a model for spatiotemporal resource fluctuations,
and we illustrate that random dynamic colorings often diminish the effects of
background heterogeneity relative to a proper two-coloring.
acknowledgement: 'We thank Igor Erovenko for many helpful comments on an earlier version
of this paper. : Army Research Laboratory (grant W911NF-18-2-0265) (M.A.N.); the
Bill & Melinda Gates Foundation (grant OPP1148627) (M.A.N.); the NVIDIA Corporation
(A.M.). The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.'
article_number: e1008402
article_processing_charge: No
article_type: original
author:
- first_name: Kamran
full_name: Kaveh, Kamran
last_name: Kaveh
- first_name: Alex
full_name: McAvoy, Alex
last_name: McAvoy
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin A.
full_name: Nowak, Martin A.
last_name: Nowak
citation:
ama: Kaveh K, McAvoy A, Chatterjee K, Nowak MA. The Moran process on 2-chromatic
graphs. PLOS Computational Biology. 2020;16(11). doi:10.1371/journal.pcbi.1008402
apa: Kaveh, K., McAvoy, A., Chatterjee, K., & Nowak, M. A. (2020). The Moran
process on 2-chromatic graphs. PLOS Computational Biology. Public Library
of Science. https://doi.org/10.1371/journal.pcbi.1008402
chicago: Kaveh, Kamran, Alex McAvoy, Krishnendu Chatterjee, and Martin A. Nowak.
“The Moran Process on 2-Chromatic Graphs.” PLOS Computational Biology.
Public Library of Science, 2020. https://doi.org/10.1371/journal.pcbi.1008402.
ieee: K. Kaveh, A. McAvoy, K. Chatterjee, and M. A. Nowak, “The Moran process on
2-chromatic graphs,” PLOS Computational Biology, vol. 16, no. 11. Public
Library of Science, 2020.
ista: Kaveh K, McAvoy A, Chatterjee K, Nowak MA. 2020. The Moran process on 2-chromatic
graphs. PLOS Computational Biology. 16(11), e1008402.
mla: Kaveh, Kamran, et al. “The Moran Process on 2-Chromatic Graphs.” PLOS Computational
Biology, vol. 16, no. 11, e1008402, Public Library of Science, 2020, doi:10.1371/journal.pcbi.1008402.
short: K. Kaveh, A. McAvoy, K. Chatterjee, M.A. Nowak, PLOS Computational Biology
16 (2020).
date_created: 2020-11-18T07:20:23Z
date_published: 2020-11-05T00:00:00Z
date_updated: 2025-06-12T07:02:01Z
day: '05'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1371/journal.pcbi.1008402
external_id:
isi:
- '000591317200004'
pmid:
- '33151935'
file:
- access_level: open_access
checksum: 555456dd0e47bcf9e0994bcb95577e88
content_type: application/pdf
creator: dernst
date_created: 2020-11-18T07:26:10Z
date_updated: 2020-11-18T07:26:10Z
file_id: '8768'
file_name: 2020_PlosCompBio_Kaveh.pdf
file_size: 2498594
relation: main_file
success: 1
file_date_updated: 2020-11-18T07:26:10Z
fulldoi: https://doi.org/10.1371/journal.pcbi.1008402
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
issue: '11'
keyword:
- Ecology
- Modelling and Simulation
- Computational Theory and Mathematics
- Genetics
- Ecology
- Evolution
- Behavior and Systematics
- Molecular Biology
- Cellular and Molecular Neuroscience
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLOS Computational Biology
publication_identifier:
eissn:
- 1553-7358
issn:
- 1553-734X
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Moran process on 2-chromatic graphs
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2020'
...
---
OA_type: closed access
_id: '22527'
abstract:
- lang: eng
text: Mountain ecosystems are experiencing rapid warming resulting in ecological
changes worldwide. Projecting the response of these ecosystems to climate change
is thus crucial, but also uncertain due to complex interactions between topography,
climate, and vegetation. Here, we performed numerical simulations in a real and
a synthetic spatial domain covering a range of contrasting climatic conditions
and vegetation characteristics representative of the European Alps. Simulations
were run with the mechanistic ecohydrological model Tethys–Chloris to quantify
the drivers of ecosystem functioning and to explore the vulnerability of Alpine
ecosystems to climate change. We correlated the spatial distribution of ecohydrological
responses with that of meteorological and topographic attributes and computed
spatially explicit sensitivities of net primary productivity, transpiration, and
snow cover to air temperature, radiation, and water availability. We also quantified
how the variance in several ecohydrological processes, such as transpiration,
quickly diminishes with increasing spatial aggregation, which highlights the importance
of fine spatial resolution for resolving patterns in complex topographies. We
conducted controlled numerical experiments in the synthetic domain to disentangle
the effect of catchment orientation on ecohydrological variables, such as streamflow.
Our results support previous studies reporting an altitude threshold below which
Alpine ecosystems are water‐limited in the drier inner‐Alpine valleys and confirm
that the wetter areas are temperature‐limited. High‐resolution simulations of
mountainous areas can improve our understanding of ecosystem functioning across
spatial scales. They can also locate the areas that are the most vulnerable to
climate change and guide future measurement campaigns.
article_number: e2054
article_processing_charge: No
article_type: original
author:
- first_name: Theodoros
full_name: Mastrotheodoros, Theodoros
last_name: Mastrotheodoros
- first_name: Christoforos
full_name: Pappas, Christoforos
last_name: Pappas
- first_name: Peter
full_name: Molnar, Peter
last_name: Molnar
- first_name: Paolo
full_name: Burlando, Paolo
last_name: Burlando
- first_name: Panagiotis
full_name: Hadjidoukas, Panagiotis
last_name: Hadjidoukas
- first_name: Simone
full_name: Fatichi, Simone
id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
last_name: Fatichi
citation:
ama: 'Mastrotheodoros T, Pappas C, Molnar P, Burlando P, Hadjidoukas P, Fatichi
S. Ecohydrological dynamics in the Alps: Insights from a modelling analysis of
the spatial variability. Ecohydrology. 2019;12(1). doi:10.1002/eco.2054'
apa: 'Mastrotheodoros, T., Pappas, C., Molnar, P., Burlando, P., Hadjidoukas, P.,
& Fatichi, S. (2019). Ecohydrological dynamics in the Alps: Insights from
a modelling analysis of the spatial variability. Ecohydrology. Wiley. https://doi.org/10.1002/eco.2054'
chicago: 'Mastrotheodoros, Theodoros, Christoforos Pappas, Peter Molnar, Paolo Burlando,
Panagiotis Hadjidoukas, and Simone Fatichi. “Ecohydrological Dynamics in the Alps:
Insights from a Modelling Analysis of the Spatial Variability.” Ecohydrology.
Wiley, 2019. https://doi.org/10.1002/eco.2054.'
ieee: 'T. Mastrotheodoros, C. Pappas, P. Molnar, P. Burlando, P. Hadjidoukas, and
S. Fatichi, “Ecohydrological dynamics in the Alps: Insights from a modelling analysis
of the spatial variability,” Ecohydrology, vol. 12, no. 1. Wiley, 2019.'
ista: 'Mastrotheodoros T, Pappas C, Molnar P, Burlando P, Hadjidoukas P, Fatichi
S. 2019. Ecohydrological dynamics in the Alps: Insights from a modelling analysis
of the spatial variability. Ecohydrology. 12(1), e2054.'
mla: 'Mastrotheodoros, Theodoros, et al. “Ecohydrological Dynamics in the Alps:
Insights from a Modelling Analysis of the Spatial Variability.” Ecohydrology,
vol. 12, no. 1, e2054, Wiley, 2019, doi:10.1002/eco.2054.'
short: T. Mastrotheodoros, C. Pappas, P. Molnar, P. Burlando, P. Hadjidoukas, S.
Fatichi, Ecohydrology 12 (2019).
das_tickbox: '1'
date_created: 2026-07-27T12:30:24Z
date_published: 2019-01-01T00:00:00Z
date_updated: 2026-08-06T07:44:22Z
day: '01'
doi: 10.1002/eco.2054
extern: '1'
fulldoi: https://doi.org/10.1002/eco.2054
intvolume: ' 12'
issue: '1'
keyword:
- Alpine ecohydrology
- Climate change
- Ecosystem sensitivity
- Numerical modelling
- Spatialheterogeneity
language:
- iso: eng
month: '01'
oa_version: None
publication: Ecohydrology
publication_identifier:
eissn:
- 1936-0592
issn:
- 1936-0584
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Ecohydrological dynamics in the Alps: Insights from a modelling analysis of
the spatial variability'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2019'
...
---
OA_place: publisher
OA_type: free access
_id: '22522'
abstract:
- lang: eng
text: The increase in atmospheric CO2 in the future is one of the most certain projections
in environmental sciences. Understanding whether vegetation carbon assimilation,
growth, and changes in vegetation carbon stocks are affected by higher atmospheric
CO2 and translating this understanding in mechanistic vegetation models is of
utmost importance. This is highlighted by inconsistencies between global-scale
studies that attribute terrestrial carbon sinks to CO2 stimulation of gross and
net primary production on the one hand, and forest inventories, tree-scale studies,
and plant physiological evidence showing a much less pronounced CO2 fertilization
effect on the other hand. Here, we review how plant carbon sources and sinks are
currently described in terrestrial biosphere models. We highlight an uneven representation
of complexity between the modelling of photosynthesis and other processes, such
as plant respiration, direct carbon sinks, and carbon allocation, largely driven
by available observations. Despite a general lack of data on carbon sink dynamics
to drive model improvements, ways forward toward a mechanistic representation
of plant carbon sinks are discussed, leveraging on results obtained from plant-scale
models and on observations geared toward model developments.
article_processing_charge: No
article_type: review
author:
- first_name: Simone
full_name: Fatichi, Simone
id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
last_name: Fatichi
- first_name: Christoforos
full_name: Pappas, Christoforos
last_name: Pappas
- first_name: Jakob
full_name: Zscheischler, Jakob
last_name: Zscheischler
- first_name: Sebastian
full_name: Leuzinger, Sebastian
last_name: Leuzinger
citation:
ama: Fatichi S, Pappas C, Zscheischler J, Leuzinger S. Modelling carbon sources
and sinks in terrestrial vegetation. New Phytologist. 2019;221(2):652-668.
doi:10.1111/nph.15451
apa: Fatichi, S., Pappas, C., Zscheischler, J., & Leuzinger, S. (2019). Modelling
carbon sources and sinks in terrestrial vegetation. New Phytologist. Wiley.
https://doi.org/10.1111/nph.15451
chicago: Fatichi, Simone, Christoforos Pappas, Jakob Zscheischler, and Sebastian
Leuzinger. “Modelling Carbon Sources and Sinks in Terrestrial Vegetation.” New
Phytologist. Wiley, 2019. https://doi.org/10.1111/nph.15451.
ieee: S. Fatichi, C. Pappas, J. Zscheischler, and S. Leuzinger, “Modelling carbon
sources and sinks in terrestrial vegetation,” New Phytologist, vol. 221,
no. 2. Wiley, pp. 652–668, 2019.
ista: Fatichi S, Pappas C, Zscheischler J, Leuzinger S. 2019. Modelling carbon sources
and sinks in terrestrial vegetation. New Phytologist. 221(2), 652–668.
mla: Fatichi, Simone, et al. “Modelling Carbon Sources and Sinks in Terrestrial
Vegetation.” New Phytologist, vol. 221, no. 2, Wiley, 2019, pp. 652–68,
doi:10.1111/nph.15451.
short: S. Fatichi, C. Pappas, J. Zscheischler, S. Leuzinger, New Phytologist 221
(2019) 652–668.
das_tickbox: '1'
date_created: 2026-07-27T12:30:24Z
date_published: 2019-01-01T00:00:00Z
date_updated: 2026-08-06T07:39:23Z
day: '01'
doi: 10.1111/nph.15451
extern: '1'
external_id:
pmid:
- '30339280'
fulldoi: https://doi.org/10.1111/nph.15451
intvolume: ' 221'
issue: '2'
keyword:
- Ecosystem modelling
- Nonstructural carbohydrates
- Carbon cycle
- Photosynthesis
- Plant growth
- respiration
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/nph.15451
month: '01'
oa: 1
oa_version: Published Version
page: 652-668
pmid: 1
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
issn:
- 0028-646X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modelling carbon sources and sinks in terrestrial vegetation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 221
year: '2019'
...
---
OA_type: closed access
_id: '22549'
abstract:
- lang: eng
text: "The time that rainfall takes to reach the outlet of a catchment as discharge
(transit time) is a fundamental and\r\nintegrated measure of catchment hydrological
processes and solute transport mechanisms. As such, many efforts\r\nhave been
dedicated to its understanding and quantification. However, defining and ranking
which factors,\r\ninternal and external to the system, control the distributions
of transit time is still an open challenge. Here, we\r\ndevelop a two-stage approach
to explore climate and topography controls on transit time, using a fully distributed
hydrological model coupled with a transport component. Specifically, we apply
the model to two\r\nsynthetic topographies under five observed climate regimes.
With this setup, water fluxes from two years of daily\r\nrainfall events are singularly
tracked across the catchments to then derive the distributions of transit time
and\r\nfraction of young water for each combination of topography and climate.
Results highlight a considerable\r\nvariability of transit times in all climates
and a pronounced effect of topography within a given climate. They\r\nfurther
reveal that for wet climates it is possible to define a curve describing water
transit time as a function of\r\ncumulative discharge that only depends on topographic
properties. On the contrary, in dry climates the variability of transit time and
young water fraction is much larger and not amenable to a simple summary. Despite\r\nsimplifications,
quantitative model-based inferences of transit time distributions are useful to
better understand\r\nhow climate and topography affect catchment functioning."
article_processing_charge: No
article_type: original
author:
- first_name: Federica
full_name: Remondi, Federica
last_name: Remondi
- first_name: Martina
full_name: Botter, Martina
last_name: Botter
- first_name: Paolo
full_name: Burlando, Paolo
last_name: Burlando
- first_name: Simone
full_name: Fatichi, Simone
id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
last_name: Fatichi
citation:
ama: 'Remondi F, Botter M, Burlando P, Fatichi S. Variability of transit time distributions
with climate and topography: A modelling approach. Journal of Hydrology.
2019;569:37-50. doi:10.1016/j.jhydrol.2018.11.011'
apa: 'Remondi, F., Botter, M., Burlando, P., & Fatichi, S. (2019). Variability
of transit time distributions with climate and topography: A modelling approach.
Journal of Hydrology. Elsevier. https://doi.org/10.1016/j.jhydrol.2018.11.011'
chicago: 'Remondi, Federica, Martina Botter, Paolo Burlando, and Simone Fatichi.
“Variability of Transit Time Distributions with Climate and Topography: A Modelling
Approach.” Journal of Hydrology. Elsevier, 2019. https://doi.org/10.1016/j.jhydrol.2018.11.011.'
ieee: 'F. Remondi, M. Botter, P. Burlando, and S. Fatichi, “Variability of transit
time distributions with climate and topography: A modelling approach,” Journal
of Hydrology, vol. 569. Elsevier, pp. 37–50, 2019.'
ista: 'Remondi F, Botter M, Burlando P, Fatichi S. 2019. Variability of transit
time distributions with climate and topography: A modelling approach. Journal
of Hydrology. 569, 37–50.'
mla: 'Remondi, Federica, et al. “Variability of Transit Time Distributions with
Climate and Topography: A Modelling Approach.” Journal of Hydrology, vol.
569, Elsevier, 2019, pp. 37–50, doi:10.1016/j.jhydrol.2018.11.011.'
short: F. Remondi, M. Botter, P. Burlando, S. Fatichi, Journal of Hydrology 569
(2019) 37–50.
das_tickbox: '1'
date_created: 2026-07-27T12:30:24Z
date_published: 2019-02-01T00:00:00Z
date_updated: 2026-08-06T08:12:57Z
day: '01'
doi: 10.1016/j.jhydrol.2018.11.011
extern: '1'
fulldoi: https://doi.org/10.1016/j.jhydrol.2018.11.011
intvolume: ' 569'
keyword:
- Transit time distributions
- Young water
- Climate
- Topography
- Distributed hydrological modelling
language:
- iso: eng
month: '02'
oa_version: None
page: 37-50
publication: Journal of Hydrology
publication_identifier:
eissn:
- 1879-2707
issn:
- 0022-1694
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Variability of transit time distributions with climate and topography: A modelling
approach'
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 569
year: '2019'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '22540'
abstract:
- lang: eng
text: The reliable partitioning of the terrestrial latent heat flux into evaporation
(E) and transpiration (T) is important for linking carbon and water cycles and
for better understanding ecosystem functioning at local, regional and global scales.
Previous research revealed that the transpiration-to-evapotranspiration ratio
(T/ET) is well constrained across ecosystems and is nearly independent of vegetation
characteristics and climate. Here we investigated the reasons for such a global
constancy in present-day T/ET by jointly analysing observations and process-based
model simulations. Using this framework, we also quantified how the ratio T/ET
could be influenced by changing climate. For present conditions, we found that
the various components of land surface evaporation (bare soil evaporation, below
canopy soil evaporation, evaporation from interception), and their respective
ratios to plant transpiration, depend largely on local climate and equilibrium
vegetation properties. The systematic covariation between local vegetation characteristics
and climate, resulted in a globally constrained value of T/ET = ∼70 ± 9% for undisturbed
ecosystems, nearly independent of specific climate and vegetation attributes.
Moreover, changes in precipitation amounts and patterns, increasing air temperatures,
atmospheric CO2 concentration, and specific leaf area (the ratio of leaf area
per leaf mass) was found to affect T/ET in various manners. However, even extreme
changes in the aforementioned factors did not significantly modify T/ET.
article_number: '104012'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Athanasios
full_name: Paschalis, Athanasios
last_name: Paschalis
- first_name: Simone
full_name: Fatichi, Simone
id: cf8e546b-a9b0-11f0-a43b-aa89ed1b56d6
last_name: Fatichi
- first_name: Christoforos
full_name: Pappas, Christoforos
last_name: Pappas
- first_name: Dani
full_name: Or, Dani
last_name: Or
citation:
ama: Paschalis A, Fatichi S, Pappas C, Or D. Covariation of vegetation and climate
constrains present and future T/ET variability. Environmental Research Letters.
2018;13(10). doi:10.1088/1748-9326/aae267
apa: Paschalis, A., Fatichi, S., Pappas, C., & Or, D. (2018). Covariation of
vegetation and climate constrains present and future T/ET variability. Environmental
Research Letters. IOP Publishing . https://doi.org/10.1088/1748-9326/aae267
chicago: Paschalis, Athanasios, Simone Fatichi, Christoforos Pappas, and Dani Or.
“Covariation of Vegetation and Climate Constrains Present and Future T/ET Variability.”
Environmental Research Letters. IOP Publishing , 2018. https://doi.org/10.1088/1748-9326/aae267.
ieee: A. Paschalis, S. Fatichi, C. Pappas, and D. Or, “Covariation of vegetation
and climate constrains present and future T/ET variability,” Environmental
Research Letters, vol. 13, no. 10. IOP Publishing , 2018.
ista: Paschalis A, Fatichi S, Pappas C, Or D. 2018. Covariation of vegetation and
climate constrains present and future T/ET variability. Environmental Research
Letters. 13(10), 104012.
mla: Paschalis, Athanasios, et al. “Covariation of Vegetation and Climate Constrains
Present and Future T/ET Variability.” Environmental Research Letters, vol.
13, no. 10, 104012, IOP Publishing , 2018, doi:10.1088/1748-9326/aae267.
short: A. Paschalis, S. Fatichi, C. Pappas, D. Or, Environmental Research Letters
13 (2018).
das_tickbox: '1'
date_created: 2026-07-27T12:30:24Z
date_published: 2018-10-05T00:00:00Z
date_updated: 2026-08-06T07:46:04Z
day: '05'
ddc:
- '550'
doi: 10.1088/1748-9326/aae267
extern: '1'
fulldoi: https://doi.org/10.1088/1748-9326/aae267
has_accepted_license: '1'
intvolume: ' 13'
issue: '10'
keyword:
- T/ET
- Evapotranspiration partitioning
- Ecohydrology
- Modelling
- Climate change
language:
- iso: eng
license: https://creativecommons.org/licenses/by/3.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.1088/1748-9326/aae267
month: '10'
oa: 1
oa_version: Published Version
publication: Environmental Research Letters
publication_identifier:
eissn:
- 1748-9326
publication_status: published
publisher: 'IOP Publishing '
quality_controlled: '1'
scopus_import: '1'
status: public
title: Covariation of vegetation and climate constrains present and future T/ET variability
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
short: CC BY (3.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2018'
...