[{"month":"07","external_id":{"pmid":["12894213"]},"author":[{"first_name":"Tobias C.","last_name":"Walther","full_name":"Walther, Tobias C."},{"full_name":"Askjaer, Peter","first_name":"Peter","last_name":"Askjaer"},{"full_name":"Gentzel, Marc","last_name":"Gentzel","first_name":"Marc"},{"full_name":"Habermann, Anja","last_name":"Habermann","first_name":"Anja"},{"full_name":"Griffiths, Gareth","first_name":"Gareth","last_name":"Griffiths"},{"last_name":"Wilm","first_name":"Matthias","full_name":"Wilm, Matthias"},{"last_name":"Mattaj","first_name":"Iain W.","full_name":"Mattaj, Iain W."},{"first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","last_name":"HETZER","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X"}],"status":"public","year":"2003","citation":{"apa":"Walther, T. C., Askjaer, P., Gentzel, M., Habermann, A., Griffiths, G., Wilm, M., … Hetzer, M. (2003). RanGTP mediates nuclear pore complex assembly. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nature01898\">https://doi.org/10.1038/nature01898</a>","short":"T.C. Walther, P. Askjaer, M. Gentzel, A. Habermann, G. Griffiths, M. Wilm, I.W. Mattaj, M. Hetzer, Nature 424 (2003) 689–694.","ama":"Walther TC, Askjaer P, Gentzel M, et al. RanGTP mediates nuclear pore complex assembly. <i>Nature</i>. 2003;424(6949):689-694. doi:<a href=\"https://doi.org/10.1038/nature01898\">10.1038/nature01898</a>","mla":"Walther, Tobias C., et al. “RanGTP Mediates Nuclear Pore Complex Assembly.” <i>Nature</i>, vol. 424, no. 6949, Springer Nature, 2003, pp. 689–94, doi:<a href=\"https://doi.org/10.1038/nature01898\">10.1038/nature01898</a>.","ieee":"T. C. Walther <i>et al.</i>, “RanGTP mediates nuclear pore complex assembly,” <i>Nature</i>, vol. 424, no. 6949. Springer Nature, pp. 689–694, 2003.","ista":"Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj IW, Hetzer M. 2003. RanGTP mediates nuclear pore complex assembly. Nature. 424(6949), 689–694.","chicago":"Walther, Tobias C., Peter Askjaer, Marc Gentzel, Anja Habermann, Gareth Griffiths, Matthias Wilm, Iain W. Mattaj, and Martin Hetzer. “RanGTP Mediates Nuclear Pore Complex Assembly.” <i>Nature</i>. Springer Nature, 2003. <a href=\"https://doi.org/10.1038/nature01898\">https://doi.org/10.1038/nature01898</a>."},"date_created":"2022-04-07T07:57:02Z","keyword":["Multidisciplinary"],"title":"RanGTP mediates nuclear pore complex assembly","issue":"6949","pmid":1,"day":"30","language":[{"iso":"eng"}],"_id":"11121","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"intvolume":"       424","date_published":"2003-07-30T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-10-14T11:31:06Z","article_processing_charge":"No","quality_controlled":"1","abstract":[{"lang":"eng","text":"In metazoa, the nuclear envelope breaks down and reforms during each cell cycle. Nuclear pore complexes (NPCs), which serve as channels for transport between the nucleus and cytoplasm1, assemble into the reforming nuclear envelope in a sequential process involving association of a subset of NPC proteins, nucleoporins, with chromatin followed by the formation of a closed nuclear envelope fenestrated by NPCs2,3,4,5,6,7. How chromatin recruitment of nucleoporins and NPC assembly are regulated is unknown. Here we demonstrate that RanGTP production is required to dissociate nucleoporins Nup107, Nup153 and Nup358 from Importin β, to target them to chromatin and to induce association between separate NPC subcomplexes. Additionally, either an excess of RanGTP or removal of Importin β induces formation of NPC-containing membrane structures—annulate lamellae—both in vitro in the absence of chromatin and in vivo. Annulate lamellae formation is strongly and specifically inhibited by an excess of Importin β. The data demonstrate that RanGTP triggers distinct steps of NPC assembly, and suggest a mechanism for the spatial restriction of NPC assembly to the surface of chromatin."}],"article_type":"original","publication":"Nature","doi":"10.1038/nature01898","volume":424,"page":"689-694","oa_version":"None","publication_status":"published","scopus_import":"1","publisher":"Springer Nature","extern":"1","type":"journal_article","fulldoi":"https://doi.org/10.1038/nature01898"},{"status":"public","department":[{"_id":"DaZi"}],"year":"2003","citation":{"chicago":"Zilberman, Daniel,  Xiaofeng Cao, and Steven E. Jacobsen. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” <i>Science</i>. American Association for the Advancement of Science, 2003. <a href=\"https://doi.org/10.1126/science.1079695\">https://doi.org/10.1126/science.1079695</a>.","ista":"Zilberman D, Cao  Xiaofeng, Jacobsen SE. 2003. ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science. 299(5607), 716–719.","ieee":"D. Zilberman,  Xiaofeng Cao, and S. E. Jacobsen, “ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation,” <i>Science</i>, vol. 299, no. 5607. American Association for the Advancement of Science, pp. 716–719, 2003.","ama":"Zilberman D, Cao  Xiaofeng, Jacobsen SE. ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. <i>Science</i>. 2003;299(5607):716-719. doi:<a href=\"https://doi.org/10.1126/science.1079695\">10.1126/science.1079695</a>","short":"D. Zilberman,  Xiaofeng Cao, S.E. Jacobsen, Science 299 (2003) 716–719.","apa":"Zilberman, D., Cao,  Xiaofeng, &#38; Jacobsen, S. E. (2003). ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1079695\">https://doi.org/10.1126/science.1079695</a>","mla":"Zilberman, Daniel, et al. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” <i>Science</i>, vol. 299, no. 5607, American Association for the Advancement of Science, 2003, pp. 716–19, doi:<a href=\"https://doi.org/10.1126/science.1079695\">10.1126/science.1079695</a>."},"date_created":"2021-06-04T11:26:26Z","month":"01","external_id":{"pmid":["12522258"]},"author":[{"id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","last_name":"Zilberman","first_name":"Daniel","orcid":"0000-0002-0123-8649","full_name":"Zilberman, Daniel"},{"full_name":"Cao,  Xiaofeng","last_name":"Cao","first_name":" Xiaofeng"},{"last_name":"Jacobsen","first_name":"Steven E.","full_name":"Jacobsen, Steven E."}],"publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"intvolume":"       299","date_updated":"2021-12-14T08:43:30Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_published":"2003-01-31T00:00:00Z","keyword":["Multidisciplinary"],"title":"ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation","pmid":1,"issue":"5607","day":"31","language":[{"iso":"eng"}],"_id":"9455","doi":"10.1126/science.1079695","article_processing_charge":"No","quality_controlled":"1","abstract":[{"lang":"eng","text":"Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena. We cloned ARGONAUTE4 (AGO4) from a screen for mutants that suppress silencing of the Arabidopsis SUPERMAN(SUP) gene. The ago4-1 mutant reactivated silentSUP alleles and decreased CpNpG and asymmetric DNA methylation as well as histone H3 lysine-9 methylation. In addition,ago4-1 blocked histone and DNA methylation and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond to the retroelement AtSN1. These results suggest that AGO4 and long siRNAs direct chromatin modifications, including histone methylation and non-CpG DNA methylation."}],"article_type":"original","publication":"Science","scopus_import":"1","publisher":"American Association for the Advancement of Science","extern":"1","type":"journal_article","fulldoi":"https://doi.org/10.1126/science.1079695","volume":299,"page":"716-719","oa_version":"None","publication_status":"published"},{"doi":"10.1126/science.1059745","publication":"Science","abstract":[{"lang":"eng","text":"Epigenetic silenced alleles of the Arabidopsis SUPERMANlocus (the clark kent alleles) are associated with dense hypermethylation at noncanonical cytosines (CpXpG and asymmetric sites, where X = A, T, C, or G). A genetic screen for suppressors of a hypermethylated clark kent mutant identified nine loss-of-function alleles of CHROMOMETHYLASE3(CMT3), a novel cytosine methyltransferase homolog. These cmt3 mutants display a wild-type morphology but exhibit decreased CpXpG methylation of the SUP gene and of other sequences throughout the genome. They also show reactivated expression of endogenous retrotransposon sequences. These results show that a non-CpG DNA methyltransferase is responsible for maintaining epigenetic gene silencing."}],"article_type":"original","quality_controlled":"1","article_processing_charge":"No","type":"journal_article","extern":"1","fulldoi":"https://doi.org/10.1126/science.1059745","publisher":"American Association for the Advancement of Science","scopus_import":"1","oa_version":"None","publication_status":"published","volume":292,"page":"2077-2080","year":"2001","citation":{"ama":"Lindroth AM, Cao X, Jackson JP, et al. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. <i>Science</i>. 2001;292(5524):2077-2080. doi:<a href=\"https://doi.org/10.1126/science.1059745\">10.1126/science.1059745</a>","short":"A.M. Lindroth, X. Cao, J.P. Jackson, D. Zilberman, C.M. McCallum, S. Henikoff, S.E. Jacobsen, Science 292 (2001) 2077–2080.","apa":"Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff, S., &#38; Jacobsen, S. E. (2001). Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1059745\">https://doi.org/10.1126/science.1059745</a>","mla":"Lindroth, A. M., et al. “Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation.” <i>Science</i>, vol. 292, no. 5524, American Association for the Advancement of Science, 2001, pp. 2077–80, doi:<a href=\"https://doi.org/10.1126/science.1059745\">10.1126/science.1059745</a>.","chicago":"Lindroth, A. M., Xiaofeng Cao, James P. Jackson, Daniel Zilberman, Claire M. McCallum, Steven Henikoff, and Steven E. Jacobsen. “Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation.” <i>Science</i>. American Association for the Advancement of Science, 2001. <a href=\"https://doi.org/10.1126/science.1059745\">https://doi.org/10.1126/science.1059745</a>.","ista":"Lindroth AM, Cao X, Jackson JP, Zilberman D, McCallum CM, Henikoff S, Jacobsen SE. 2001. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. Science. 292(5524), 2077–2080.","ieee":"A. M. Lindroth <i>et al.</i>, “Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation,” <i>Science</i>, vol. 292, no. 5524. American Association for the Advancement of Science, pp. 2077–2080, 2001."},"date_created":"2021-06-02T13:35:16Z","department":[{"_id":"DaZi"}],"status":"public","author":[{"full_name":"Lindroth, A. M.","last_name":"Lindroth","first_name":"A. M."},{"full_name":"Cao, Xiaofeng","last_name":"Cao","first_name":"Xiaofeng"},{"first_name":"James P.","last_name":"Jackson","full_name":"Jackson, James P."},{"first_name":"Daniel","last_name":"Zilberman","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","full_name":"Zilberman, Daniel","orcid":"0000-0002-0123-8649"},{"full_name":"McCallum, Claire M.","last_name":"McCallum","first_name":"Claire M."},{"last_name":"Henikoff","first_name":"Steven","full_name":"Henikoff, Steven"},{"last_name":"Jacobsen","first_name":"Steven E.","full_name":"Jacobsen, Steven E."}],"external_id":{"pmid":["11349138"]},"month":"06","date_published":"2001-06-15T00:00:00Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_updated":"2021-12-14T08:40:32Z","intvolume":"       292","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"_id":"9444","language":[{"iso":"eng"}],"pmid":1,"issue":"5524","day":"15","title":"Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation","keyword":["Multidisciplinary"]}]