---
OA_place: publisher
OA_type: hybrid
_id: '21839'
abstract:
- lang: eng
text: "Background & Aims: To develop and validate a CT-based radiomics model to
assess HVPG and predict a composite endpoint of liver-related events (LRE: decompensation
and liver-related death) in patients with cirrhosis.\r\n\r\nMethods: This retrospective
study included 357 cirrhosis patients, who received invasive HVPG measurements,
120 liver-healthy controls (training cohort) and 85 and 100 cirrhosis patients
(internal and external validation cohorts, respectively), and contrast-enhanced
abdominal CTs. After volumetric segmentation of the liver and spleen on CT, Bayesian
parameter optimization was used for selection of extracted features and hyperparameter
tuning in random forest or elastic net models. Prediction accuracy was evaluated
using Pearson correlation coefficients of predicted (’radio-HVPG’) and invasive
HVPG. Discrimination between relevant HVPG cut-offs was determined by receiver
operating characteristic (ROC) analysis. The predictive value of radio-HVPG and
invasive-HVPG for LRE was compared using Cox regression models.\r\n\r\nResults:
Radio-HVPG, predicted by an optimized random forest model based on 74 selected
CT features, correlated with invasive-HVPG and detected clinically significant
portal hypertension (CSPH: HVPG ≥ 10 mmHg) on the internal (Pearson r = 0.63,
AUC 0.89 [95% CI: 0.81–0.96]) and external (Pearson r = 0.62, AUC 0.80 [95% CI:
0.64–0.91]) validation cohorts. Radio-HVPG predicted LRE when adjusting for MELD
and albumin (adjusted HR: 1.14 [95% CI: 1.04–1.25], p = 0.005) and performed similarly
to invasive-HVPG.\r\n\r\nConclusions: Radiomic features accurately predict HVPG
in patients with cirrhosis and allow risk stratification for LRE in a radiomics-clinical
signature."
acknowledgement: "The computational results presented were partly obtained using the
CLIP cluster (https://clip.science/). The authors thank Clemens Watzenboeck from
the Medical University of Vienna for the assistance in code upload and repository
maintenance. The authors dedicate this work to the memory of Martin Watzenboeck,
who served as first author and whose vision and scientific rigor were fundamental
to the conception and completion of this study. Open Access funding provided by
Medizinische Universitat Wien/KEMÖ. This work was supported by the Vienna Science
and Technology Fund (WWTF) through projects VRG15-005 and NXT 19-008 granted to
J.M and the Clinical Research Group MOTION, Medical University of Vienna, Vienna,
Austria – a Clinical Research Group Programme project funded by the Ludwig Boltzmann
Gesellschaft (Grant Nr LBG_KFG_22_32) with funds from the Fonds Zukunft Österreich.\r\n\r\nP-E.R.'s
research laboratory is supported by the Fondation pour la Recherche Médicale (FRM
EQU202303016287), “Institut National de la Santé et de la Recherche Médicale” (ATIP
AVENIR), the “Agence Nationale de la Recherche” (ANR-18-CE14-0006-01, RHU QUID-NASH,
ANR-18-IDEX-0001, ANR-22-CE14-0002) by « Émergence, Ville de Paris », by Fondation
ARC, by the European Union's Horizon 2020 research and innovation programme under
grant agreement No 847949 and by France 2030 RHU LIVER-TRACK."
article_number: e70633
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Celine
full_name: Sin, Celine
last_name: Sin
- first_name: Martin Luther
full_name: Watzenboeck, Martin Luther
last_name: Watzenboeck
- first_name: Eugenia B
full_name: Iofinova, Eugenia B
id: f9a17499-f6e0-11ea-865d-fdf9a3f77117
last_name: Iofinova
orcid: 0000-0002-7778-3221
- first_name: Lorenz
full_name: Balcar, Lorenz
last_name: Balcar
- first_name: Georg
full_name: Semmler, Georg
last_name: Semmler
- first_name: Bernhard
full_name: Scheiner, Bernhard
last_name: Scheiner
- first_name: Katharina
full_name: Lampichler, Katharina
last_name: Lampichler
- first_name: Mattias
full_name: Mandorfer, Mattias
last_name: Mandorfer
- first_name: Lucile
full_name: Moga, Lucile
last_name: Moga
- first_name: Pierre‐Emmanuel
full_name: Rautou, Pierre‐Emmanuel
last_name: Rautou
- first_name: Maxime
full_name: Ronot, Maxime
last_name: Ronot
- first_name: Jörg
full_name: Menche, Jörg
last_name: Menche
- first_name: Thomas
full_name: Reiberger, Thomas
last_name: Reiberger
- first_name: Martina
full_name: Scharitzer, Martina
last_name: Scharitzer
citation:
ama: Sin C, Watzenboeck ML, Iofinova EB, et al. Radiomics‐based assessment of portal
hypertension severity and risk stratification of cirrhotic patients using routine
CT scans. Liver International. 2026;46(5). doi:10.1111/liv.70633
apa: Sin, C., Watzenboeck, M. L., Iofinova, E. B., Balcar, L., Semmler, G., Scheiner,
B., … Scharitzer, M. (2026). Radiomics‐based assessment of portal hypertension
severity and risk stratification of cirrhotic patients using routine CT scans.
Liver International. Wiley. https://doi.org/10.1111/liv.70633
chicago: Sin, Celine, Martin Luther Watzenboeck, Eugenia B Iofinova, Lorenz Balcar,
Georg Semmler, Bernhard Scheiner, Katharina Lampichler, et al. “Radiomics‐based
Assessment of Portal Hypertension Severity and Risk Stratification of Cirrhotic
Patients Using Routine CT Scans.” Liver International. Wiley, 2026. https://doi.org/10.1111/liv.70633.
ieee: C. Sin et al., “Radiomics‐based assessment of portal hypertension severity
and risk stratification of cirrhotic patients using routine CT scans,” Liver
International, vol. 46, no. 5. Wiley, 2026.
ista: Sin C, Watzenboeck ML, Iofinova EB, Balcar L, Semmler G, Scheiner B, Lampichler
K, Mandorfer M, Moga L, Rautou P, Ronot M, Menche J, Reiberger T, Scharitzer M.
2026. Radiomics‐based assessment of portal hypertension severity and risk stratification
of cirrhotic patients using routine CT scans. Liver International. 46(5), e70633.
mla: Sin, Celine, et al. “Radiomics‐based Assessment of Portal Hypertension Severity
and Risk Stratification of Cirrhotic Patients Using Routine CT Scans.” Liver
International, vol. 46, no. 5, e70633, Wiley, 2026, doi:10.1111/liv.70633.
short: C. Sin, M.L. Watzenboeck, E.B. Iofinova, L. Balcar, G. Semmler, B. Scheiner,
K. Lampichler, M. Mandorfer, L. Moga, P. Rautou, M. Ronot, J. Menche, T. Reiberger,
M. Scharitzer, Liver International 46 (2026).
date_created: 2026-05-07T08:51:47Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-05-18T07:20:20Z
day: '01'
ddc:
- '570'
doi: 10.1111/liv.70633
external_id:
pmid:
- '41943460'
file:
- access_level: open_access
checksum: fafcc0b88b8e8caed85849627305d9ba
content_type: application/pdf
creator: dernst
date_created: 2026-05-18T07:10:31Z
date_updated: 2026-05-18T07:10:31Z
file_id: '21888'
file_name: 2026_LiverInternational_Sin.pdf
file_size: 3550462
relation: main_file
success: 1
file_date_updated: 2026-05-18T07:10:31Z
has_accepted_license: '1'
intvolume: ' 46'
issue: '5'
keyword:
- computed tomography
- liver
- portal hypertension
- radiomics
- spleen
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Liver International
publication_identifier:
eissn:
- 1478-3231
issn:
- 1478-3223
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Radiomics‐based assessment of portal hypertension severity and risk stratification
of cirrhotic patients using routine CT scans
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 46
year: '2026'
...
---
OA_place: publisher
OA_type: green
_id: '21572'
abstract:
- lang: eng
text: This study focuses on advancing metascintillators to break the 100 ps barrier
and approach the 10 ps target. We exploitnanophotonic features, specifically the
Purcell effect, to shape and enhance the scintillation properties of the first-generation
metascintillator. We demonstrate that a faster emission is achievable along with
a more efficient conversionefficiency. This results in a coincidence time resolution
improved by a factor of 1.3, crucial for TOF-PET applications.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: A.
full_name: Shultzman, A.
last_name: Shultzman
- first_name: R.
full_name: Schütz, R.
last_name: Schütz
- first_name: Y.
full_name: Kurman, Y.
last_name: Kurman
- first_name: N.
full_name: Lahav, N.
last_name: Lahav
- first_name: G.
full_name: Dosovitskiy, G.
last_name: Dosovitskiy
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: Y.
full_name: Bekenstein, Y.
last_name: Bekenstein
- first_name: G.
full_name: Konstantinou, G.
last_name: Konstantinou
- first_name: R.
full_name: Latella, R.
last_name: Latella
- first_name: L.
full_name: Zhang, L.
last_name: Zhang
- first_name: F.
full_name: Loignon-Houle, F.
last_name: Loignon-Houle
- first_name: A. J.
full_name: Gonzalez, A. J.
last_name: Gonzalez
- first_name: J. M.
full_name: Benlloch, J. M.
last_name: Benlloch
- first_name: I.
full_name: Kaminer, I.
last_name: Kaminer
- first_name: P.
full_name: Lecoq, P.
last_name: Lecoq
citation:
ama: Shultzman A, Schütz R, Kurman Y, et al. Toward a second generation of metascintillators
using the Purcell effect. IEEE Transactions on Radiation and Plasma Medical
Sciences. 2025;9(2):141-147. doi:10.1109/trpms.2024.3471251
apa: Shultzman, A., Schütz, R., Kurman, Y., Lahav, N., Dosovitskiy, G., Roques-Carmes,
C., … Lecoq, P. (2025). Toward a second generation of metascintillators using
the Purcell effect. IEEE Transactions on Radiation and Plasma Medical Sciences.
Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/trpms.2024.3471251
chicago: Shultzman, A., R. Schütz, Y. Kurman, N. Lahav, G. Dosovitskiy, Charles
Roques-Carmes, Y. Bekenstein, et al. “Toward a Second Generation of Metascintillators
Using the Purcell Effect.” IEEE Transactions on Radiation and Plasma Medical
Sciences. Institute of Electrical and Electronics Engineers, 2025. https://doi.org/10.1109/trpms.2024.3471251.
ieee: A. Shultzman et al., “Toward a second generation of metascintillators
using the Purcell effect,” IEEE Transactions on Radiation and Plasma Medical
Sciences, vol. 9, no. 2. Institute of Electrical and Electronics Engineers,
pp. 141–147, 2025.
ista: Shultzman A, Schütz R, Kurman Y, Lahav N, Dosovitskiy G, Roques-Carmes C,
Bekenstein Y, Konstantinou G, Latella R, Zhang L, Loignon-Houle F, Gonzalez AJ,
Benlloch JM, Kaminer I, Lecoq P. 2025. Toward a second generation of metascintillators
using the Purcell effect. IEEE Transactions on Radiation and Plasma Medical Sciences.
9(2), 141–147.
mla: Shultzman, A., et al. “Toward a Second Generation of Metascintillators Using
the Purcell Effect.” IEEE Transactions on Radiation and Plasma Medical Sciences,
vol. 9, no. 2, Institute of Electrical and Electronics Engineers, 2025, pp. 141–47,
doi:10.1109/trpms.2024.3471251.
short: A. Shultzman, R. Schütz, Y. Kurman, N. Lahav, G. Dosovitskiy, C. Roques-Carmes,
Y. Bekenstein, G. Konstantinou, R. Latella, L. Zhang, F. Loignon-Houle, A.J. Gonzalez,
J.M. Benlloch, I. Kaminer, P. Lecoq, IEEE Transactions on Radiation and Plasma
Medical Sciences 9 (2025) 141–147.
date_created: 2026-03-30T12:22:47Z
date_published: 2025-02-01T00:00:00Z
date_updated: 2026-04-27T10:44:57Z
day: '01'
ddc:
- '530'
doi: 10.1109/trpms.2024.3471251
extern: '1'
external_id:
arxiv:
- '2406.15058'
intvolume: ' 9'
issue: '2'
keyword:
- Nanophotonics
- Positron emission tomography
- scintillators
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2406.15058
month: '02'
oa: 1
oa_version: Preprint
page: 141-147
publication: IEEE Transactions on Radiation and Plasma Medical Sciences
publication_identifier:
eissn:
- 2469-7303
issn:
- '2469-7311 '
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Toward a second generation of metascintillators using the Purcell effect
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2025'
...
---
_id: '14502'
abstract:
- lang: eng
text: A precise quantitative description of the ultrastructural characteristics
underlying biological mechanisms is often key to their understanding. This is
particularly true for dynamic extra- and intracellular filamentous assemblies,
playing a role in cell motility, cell integrity, cytokinesis, tissue formation
and maintenance. For example, genetic manipulation or modulation of actin regulatory
proteins frequently manifests in changes of the morphology, dynamics, and ultrastructural
architecture of actin filament-rich cell peripheral structures, such as lamellipodia
or filopodia. However, the observed ultrastructural effects often remain subtle
and require sufficiently large datasets for appropriate quantitative analysis.
The acquisition of such large datasets has been enabled by recent advances in
high-throughput cryo-electron tomography (cryo-ET) methods. This also necessitates
the development of complementary approaches to maximize the extraction of relevant
biological information. We have developed a computational toolbox for the semi-automatic
quantification of segmented and vectorized fila- mentous networks from pre-processed
cryo-electron tomograms, facilitating the analysis and cross-comparison of multiple
experimental conditions. GUI-based components simplify the processing of data
and allow users to obtain a large number of ultrastructural parameters describing
filamentous assemblies. We demonstrate the feasibility of this workflow by analyzing
cryo-ET data of untreated and chemically perturbed branched actin filament networks
and that of parallel actin filament arrays. In principle, the computational toolbox
presented here is applicable for data analysis comprising any type of filaments
in regular (i.e. parallel) or random arrangement. We show that it can ease the
identification of key differences between experimental groups and facilitate the
in-depth analysis of ultrastructural data in a time-efficient manner.
author:
- first_name: Georgi A
full_name: Dimchev, Georgi A
id: 38C393BE-F248-11E8-B48F-1D18A9856A87
last_name: Dimchev
orcid: 0000-0001-8370-6161
- first_name: Behnam
full_name: Amiri, Behnam
last_name: Amiri
- first_name: Florian
full_name: Fäßler, Florian
id: 404F5528-F248-11E8-B48F-1D18A9856A87
last_name: Fäßler
orcid: 0000-0001-7149-769X
- first_name: Martin
full_name: Falcke, Martin
last_name: Falcke
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
citation:
ama: Dimchev GA, Amiri B, Fäßler F, Falcke M, Schur FK. Computational toolbox for
ultrastructural quantitative analysis of filament networks in cryo-ET data. 2023.
doi:10.15479/AT:ISTA:14502
apa: Dimchev, G. A., Amiri, B., Fäßler, F., Falcke, M., & Schur, F. K. (2023).
Computational toolbox for ultrastructural quantitative analysis of filament networks
in cryo-ET data. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:14502
chicago: Dimchev, Georgi A, Behnam Amiri, Florian Fäßler, Martin Falcke, and Florian
KM Schur. “Computational Toolbox for Ultrastructural Quantitative Analysis of
Filament Networks in Cryo-ET Data.” Institute of Science and Technology Austria,
2023. https://doi.org/10.15479/AT:ISTA:14502.
ieee: G. A. Dimchev, B. Amiri, F. Fäßler, M. Falcke, and F. K. Schur, “Computational
toolbox for ultrastructural quantitative analysis of filament networks in cryo-ET
data.” Institute of Science and Technology Austria, 2023.
ista: Dimchev GA, Amiri B, Fäßler F, Falcke M, Schur FK. 2023. Computational toolbox
for ultrastructural quantitative analysis of filament networks in cryo-ET data,
Institute of Science and Technology Austria, 10.15479/AT:ISTA:14502.
mla: Dimchev, Georgi A., et al. Computational Toolbox for Ultrastructural Quantitative
Analysis of Filament Networks in Cryo-ET Data. Institute of Science and Technology
Austria, 2023, doi:10.15479/AT:ISTA:14502.
short: G.A. Dimchev, B. Amiri, F. Fäßler, M. Falcke, F.K. Schur, (2023).
corr_author: '1'
date_created: 2023-11-08T19:40:54Z
date_published: 2023-11-21T00:00:00Z
date_updated: 2025-04-15T08:25:41Z
day: '21'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.15479/AT:ISTA:14502
file:
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checksum: a8b9adeb53a4109dea4d5e39fa1acccf
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creator: fschur
date_created: 2023-11-08T20:23:07Z
date_updated: 2023-11-08T20:23:07Z
file_id: '14503'
file_name: Computational_Toolbox_v1.2.zip
file_size: 347641117
relation: main_file
success: 1
- access_level: open_access
checksum: 14db2addbfca61a085ba301ed6f2900b
content_type: text/plain
creator: dernst
date_created: 2023-11-21T08:20:23Z
date_updated: 2023-11-21T08:20:23Z
file_id: '14586'
file_name: Readme.txt
file_size: 1522
relation: main_file
success: 1
file_date_updated: 2023-11-21T08:20:23Z
has_accepted_license: '1'
keyword:
- cryo-electron tomography
- actin cytoskeleton
- toolbox
license: https://choosealicense.com/licenses/agpl-3.0/
month: '11'
oa: 1
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
grant_number: P33367
name: Structure and isoform diversity of the Arp2/3 complex
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '10290'
relation: used_for_analysis_in
status: public
status: public
title: Computational toolbox for ultrastructural quantitative analysis of filament
networks in cryo-ET data
tmp:
legal_code_url: https://www.gnu.org/licenses/agpl-3.0.html
name: GNU Affero General Public License v3.0
short: 'GNU AGPLv3 '
type: software
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
OA_place: publisher
_id: '12491'
abstract:
- lang: eng
text: "The extracellular matrix (ECM) is a hydrated and complex three-dimensional
network consisting of proteins, polysaccharides, and water. It provides structural
scaffolding for the cells embedded within it and is essential in regulating numerous
physiological processes, including cell migration and proliferation, wound healing,
and stem cell fate. \r\nDespite extensive study, detailed structural knowledge
of ECM components in physiologically relevant conditions is still rudimentary.
This is due to methodological limitations in specimen preparation protocols which
are incompatible with keeping large samples, such as the ECM, in their native
state for subsequent imaging. Conventional electron microscopy (EM) techniques
rely on fixation, dehydration, contrasting, and sectioning. This results in the
alteration of a highly hydrated environment and the potential introduction of
artifacts. Other structural biology techniques, such as nuclear magnetic resonance
(NMR) spectroscopy and X-ray crystallography, allow high-resolution analysis of
protein structures but only work on homogenous and purified samples, hence lacking
contextual information. Currently, no approach exists for the ultrastructural
and structural study of extracellular components under native conditions in a
physiological, 3D environment. \r\nIn this thesis, I have developed a workflow
that allows for the ultrastructural analysis of the ECM in near-native conditions
at molecular resolution. The developments I introduced include implementing a
novel specimen preparation workflow for cell-derived matrices (CDMs) to render
them compatible with ion-beam milling and subsequent high-resolution cryo-electron
tomography (ET). \r\nTo this end, I have established protocols to generate CDMs
grown over several weeks on EM grids that are compatible with downstream cryo-EM
sample preparation and imaging techniques. Characterization of these ECMs confirmed
that they contain essential ECM components such as collagen I, collagen VI, and
fibronectin I in high abundance and hence represent a bona fide biologically-relevant
sample. I successfully optimized vitrification of these specimens by testing various
vitrification techniques and cryoprotectants. \r\nIn order to obtain high-resolution
molecular insights into the ultrastructure and organization of CDMs, I established
cryo-focused ion beam scanning electron microscopy (FIBSEM) on these challenging
and complex specimens. I explored different approaches for the creation of thin
cryo-lamellae by FIB milling and succeeded in optimizing the cryo-lift-out technique,
resulting in high-quality lamellae of approximately 200 nm thickness. \r\nHigh-resolution
Cryo-ET of these lamellae revealed for the first time the architecture of native
CDM in the context of matrix-secreting cells. This allowed for the in situ visualization
of fibrillar matrix proteins such as collagen, laying the foundation for future
structural and ultrastructural characterization of these proteins in their near-native
environment. \r\nIn summary, in this thesis, I present a novel workflow that combines
state-of-the-art cryo-EM specimen preparation and imaging technologies to permit
characterization of the ECM, an important tissue component in higher organisms.
This innovative and highly versatile workflow will enable addressing far-reaching
questions on ECM architecture, composition, and reciprocal ECM-cell interactions."
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Bettina
full_name: Zens, Bettina
id: 45FD126C-F248-11E8-B48F-1D18A9856A87
last_name: Zens
orcid: 0000-0002-9561-1239
citation:
ama: Zens B. Ultrastructural characterization of natively preserved extracellular
matrix by cryo-electron tomography. 2023. doi:10.15479/at:ista:12491
apa: Zens, B. (2023). Ultrastructural characterization of natively preserved
extracellular matrix by cryo-electron tomography. Institute of Science and
Technology Austria. https://doi.org/10.15479/at:ista:12491
chicago: Zens, Bettina. “Ultrastructural Characterization of Natively Preserved
Extracellular Matrix by Cryo-Electron Tomography.” Institute of Science and Technology
Austria, 2023. https://doi.org/10.15479/at:ista:12491.
ieee: B. Zens, “Ultrastructural characterization of natively preserved extracellular
matrix by cryo-electron tomography,” Institute of Science and Technology Austria,
2023.
ista: Zens B. 2023. Ultrastructural characterization of natively preserved extracellular
matrix by cryo-electron tomography. Institute of Science and Technology Austria.
mla: Zens, Bettina. Ultrastructural Characterization of Natively Preserved Extracellular
Matrix by Cryo-Electron Tomography. Institute of Science and Technology Austria,
2023, doi:10.15479/at:ista:12491.
short: B. Zens, Ultrastructural Characterization of Natively Preserved Extracellular
Matrix by Cryo-Electron Tomography, Institute of Science and Technology Austria,
2023.
corr_author: '1'
date_created: 2023-02-02T14:50:20Z
date_published: 2023-02-02T00:00:00Z
date_updated: 2026-04-07T13:49:23Z
day: '02'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: FlSc
doi: 10.15479/at:ista:12491
file:
- access_level: open_access
checksum: 069d87f025e0799bf9e3c375664264f2
content_type: application/pdf
creator: bzens
date_created: 2023-02-07T13:07:38Z
date_updated: 2024-02-08T23:30:04Z
embargo: 2024-02-07
file_id: '12527'
file_name: PhDThesis_BettinaZens_2023_final.pdf
file_size: 23082464
relation: main_file
- access_level: closed
checksum: 8c66ed203495d6e078ed1002a866520c
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: bzens
date_created: 2023-02-07T13:09:05Z
date_updated: 2024-02-08T23:30:04Z
embargo_to: open_access
file_id: '12528'
file_name: PhDThesis_BettinaZens_2023_final.docx
file_size: 106169509
relation: source_file
file_date_updated: 2024-02-08T23:30:04Z
has_accepted_license: '1'
keyword:
- cryo-EM
- cryo-ET
- FIB milling
- method development
- FIBSEM
- extracellular matrix
- ECM
- cell-derived matrices
- CDMs
- cell culture
- high pressure freezing
- HPF
- structural biology
- tomography
- collagen
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '187'
project:
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name: Integrated visual proteomics of reciprocal cell-extracellular matrix interactions
- _id: 059B463C-7A3F-11EA-A408-12923DDC885E
name: "NÃ\x96-Fonds Preis für die Jungforscherin des Jahres am IST Austria"
publication_identifier:
isbn:
- 978-3-99078-027-5
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
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relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
title: Ultrastructural characterization of natively preserved extracellular matrix
by cryo-electron tomography
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2023'
...
---
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abstract:
- lang: eng
text: "Small synthetic discrete tomography problems.\r\nSizes are 32x32, 64z64 and
256x256.\r\nProjection angles are 2, 4, and 6.\r\nNumber of labels are 3 and 5."
article_processing_charge: No
author:
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full_name: Swoboda, Paul
id: 446560C6-F248-11E8-B48F-1D18A9856A87
last_name: Swoboda
citation:
ama: Swoboda P. Synthetic discrete tomography problems. 2016. doi:10.15479/AT:ISTA:46
apa: Swoboda, P. (2016). Synthetic discrete tomography problems. Institute of Science
and Technology Austria. https://doi.org/10.15479/AT:ISTA:46
chicago: Swoboda, Paul. “Synthetic Discrete Tomography Problems.” Institute of Science
and Technology Austria, 2016. https://doi.org/10.15479/AT:ISTA:46.
ieee: P. Swoboda, “Synthetic discrete tomography problems.” Institute of Science
and Technology Austria, 2016.
ista: Swoboda P. 2016. Synthetic discrete tomography problems, Institute of Science
and Technology Austria, 10.15479/AT:ISTA:46.
mla: Swoboda, Paul. Synthetic Discrete Tomography Problems. Institute of
Science and Technology Austria, 2016, doi:10.15479/AT:ISTA:46.
short: P. Swoboda, (2016).
contributor:
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first_name: Jan
last_name: Kuske
datarep_id: '46'
date_created: 2018-12-12T12:31:31Z
date_published: 2016-09-20T00:00:00Z
date_updated: 2024-02-21T13:50:21Z
day: '20'
ddc:
- '006'
department:
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doi: 10.15479/AT:ISTA:46
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creator: system
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date_updated: 2020-07-14T12:47:02Z
file_id: '5645'
file_name: IST-2016-46-v1+1_discrete_tomography_synthetic.zip
file_size: 36058401
relation: main_file
file_date_updated: 2020-07-14T12:47:02Z
has_accepted_license: '1'
keyword:
- discrete tomography
license: https://creativecommons.org/publicdomain/zero/1.0/
month: '09'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
status: public
title: Synthetic discrete tomography problems
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2016'
...