@article{21745, abstract = {The small DAHe and DAe spectral classes comprise isolated, hydrogen-dominated atmosphere white dwarfs that exhibit variable photometric flux and Balmer line emission. These mysterious systems offer unique insight into the complex interplay between magnetic fields, stellar rotation and atmospheric activity in single white dwarfs. DAHe stars have detectable magnetic fields through Zeeman-split spectral lines, whereas DAe stars lack such splitting. We report the first discovery and characterization of magnetism in the DAe white dwarf WD J165335.21−100116.33 with new time-resolved spectropolarimetry from FORS2. We detect a weak but variable longitudinal magnetic field with values Bz > −9.2 ± 2.4 kG and Bz < −2.2 ± 1.0 kG. Independent ZTF and ATLAS photometry reveal a consistent period of P = 80.3070 ± 0.0007 h. Time-resolved optical spectroscopy obtained with six ground-based instruments demonstrates strong modulation in the strength of the Hα and Hβ Balmer line emission with P = 80.2922 ± 0.0108 h. The photometric flux and Balmer emission strength vary in antiphase, with the strongest magnetic detections coinciding with phases of low photometric flux and strong line emission. These characteristicssupport the theory that a magnetically active, temperature-inverted spot/region is producing an optically thin chromospheric emission region. Comparison with other DAe and DAHe white dwarfsreveals all systems have a strikingly similar antiphase phenomenology, reinforcing the theory that they are subject to a unified physical mechanism. With the detection of a weak magnetic field, we reclassify WD J165335.21−100116.33 as a low-field DAHe white dwarf. }, author = {Elms, Abbigail K. and Bagnulo, Stefano and Tremblay, Pier Emmanuel and Cunningham, Tim and Munday, James and Landstreet, John and El-Badry, Kareem and Caiazzo, Ilaria and Melis, Carl and Pinter, Viktoria and Weinberger, Alycia}, issn = {1365-2966}, journal = {Monthly Notices of the Royal Astronomical Society}, number = {1}, publisher = {Oxford University Press}, title = {{Detection of a weak magnetic field in the Balmer emission line white dwarf WDJ1653−1001}}, doi = {10.1093/mnras/stag505}, volume = {548}, year = {2026}, } @article{21744, abstract = {The paraventricular hypothalamus (PVH) controls behavioral and physiologic processes, including appetite, social behavior, autonomic outflow, and pituitary hormone secretion. However, molecular markers for centrally projecting PVH neuron populations remain largely undefined, and a complete census of PVH cell types has not been established. Therefore, we performed extensive single-cell/nucleus RNA sequencing to catalog PVH neuron subtypes and multiplexed error-robust fluorescence in situ hybridization (MERFISH) to map them spatially. Our spatial transcriptomic atlas resolves 26 Sim1+ and 29 GABAergic neuron populations from the PVH and surrounding areas. Additionally, projection-based profiling identified neurons that project to the parabrachial region (PB) and spinal cord, helping to determine PVH populations that regulate satiety and sympathetic nervous system activity, respectively. Notably, activation of PB-projecting PVH neurons expressing Brs3 reduces food intake, and silencing them causes obesity. Together, this atlas contributes high-resolution PVH spatial and circuit-based gene expression profiles, representing a valuable resource for the field of homeostasis.}, author = {Li, Yuxi and Butler, Trevor C. and Nardone, Stefano and Jacobs, Christopher L. and Douglass, Amelia May Barnett and Madara, Joseph C. and McDonough, Miriam C. and Tao, Jenkang and Lowenstein, Elijah D. and Wang, Luhong and Pant, Deepti and Walker, Samuel J. and Wang, Annette and Srinivasan, Harini and Yang, Zongfang and Campbell, John N. and Tsai, Linus T. and Lowell, Bradford B. and Resch, Jon M.}, issn = {2211-1247}, journal = {Cell Reports}, number = {2}, publisher = {Elsevier}, title = {{A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types}}, doi = {10.1016/j.celrep.2025.116904}, volume = {45}, year = {2026}, } @inproceedings{21719, abstract = {We develop a new algorithmic framework for designing approximation algorithms for cut-based optimization problems on capacitated undirected graphs that undergo edge insertions and deletions. Specifically, our framework dynamically maintains a variant of the hierarchical 𝑗-tree decomposition of [Madry FOCS’10], achieving a poly-logarithmic approximation factor to the graph’s cut structure and supporting edge updates in 𝑂⁡(𝑛𝜀) amortized update time, for any arbitrarily small constant 𝜀 ∈(0,1). Consequently, we obtain new trade-offs between approximation and update/query time for fundamental cut-based optimization problems in the fully dynamic setting, including all-pairs minimum cuts, sparsest cut, multi-way cut, and multi-cut. For the last three problems, these trade-offs give the first fully-dynamic algorithms achieving poly-logarithmic approximation in sub-linear time per operation. The main technical ingredient behind our dynamic hierarchy is a dynamic cut-sparsifier algorithm that can handle vertex splits with low recourse. This is achieved by white-boxing the dynamic cut sparsifier construction of [Abraham et al. FOCS’16], based on forest packing, together with new structural insights about the maintenance of these forests under vertex splits. Given the versatility of cut sparsification in both the static and dynamic graph algorithms literature, we believe this construction may be of independent interest.}, author = {Goranci, Gramoz and Henzinger, Monika H and Kiss, Peter and Momeni, Ali and Zöcklein, Gernot}, booktitle = {Proceedings of the 2026 Annual ACM SIAM Symposium on Discrete Algorithms}, isbn = {9781611978971}, issn = {15579468}, pages = {1128--1180}, publisher = {Society for Industrial and Applied Mathematics}, title = {{Dynamic hierarchical j-tree decomposition and its applications}}, doi = {10.1137/1.9781611978971.45}, volume = {2026-January}, year = {2026}, } @inproceedings{21717, abstract = {Robust Markov Decision Processes (RMDPs) generalize classical MDPs that consider uncertainties in transition probabilities by defining a set of possible transition functions. An objective is a set of runs (or infinite trajectories) of the RMDP, and the value for an objective is the maximal probability that the agent can guarantee against the adversarial environment. We consider (a) reachability objectives, where given a target set of states, the goal is to eventually arrive at one of them; and (b) parity objectives, which are a canonical representation for ω-regular objectives. The qualitative analysis problem asks whether the objective can be ensured with probability 1. In this work, we study the qualitative problem for reachability and parity objectives on RMDPs without making any assumption over the structures of the RMDPs, e.g., unichain or aperiodic. Our contributions are twofold. We first present efficient algorithms with oracle access to uncertainty sets that solve qualitative problems of reachability and parity objectives. We then report experimental results demonstrating the effectiveness of our oracle-based approach on classical RMDP examples from the literature scaling up to thousands of states.}, author = {Asadi, Ali and Chatterjee, Krishnendu and Kafshdar Goharshadi, Ehsan and Karrabi, Mehrdad and Shafiee, Ali}, booktitle = {Proceedings of the 40th AAAI Conference on Artificial Intelligence}, issn = {2374-3468}, location = {Singapore, Singapore}, number = {43}, pages = {36137--36145}, publisher = {Association for the Advancement of Artificial Intelligence}, title = {{Qualitative analysis of ω-regular objectives on robust MDPs}}, doi = {10.1609/aaai.v40i43.40931}, volume = {40}, year = {2026}, } @inproceedings{21720, abstract = {We present an exact fully-dynamic minimum cut algorithm that runs in 𝑛𝑜⁡(1) deterministic update time when the minimum cut size is at most 2Θ⁡(log3/4−𝑐⁡𝑛) for any 𝑐 >0, improving on the previous algorithm of Jin, Sun, and Thorup (SODA 2024) whose minimum cut size limit is (log⁡𝑛)𝑜⁡(1). Combined with graph sparsification, we obtain the first (1 +𝜖)-approximate fully-dynamic minimum cut algorithm on weighted graphs, for any 𝜖 ≥2−Θ⁡(log3/4−𝑐⁡𝑛), in 𝑛𝑜⁡(1) randomized update time. Our main technical contribution is a deterministic local minimum cut algorithm, which replaces the randomized LocalKCut procedure from El-Hayek, Henzinger, and Li (SODA 2025).}, author = {El-Hayek, Antoine and Henzinger, Monika H and Li, Jason}, booktitle = {Proceedings of the Annual ACM SIAM Symposium on Discrete Algorithms}, issn = {1557-9468}, location = {Vancouver, Canada}, pages = {613--663}, publisher = {Society for Industrial and Applied Mathematics}, title = {{Deterministic and exact fully-dynamic minimum cut of superpolylogarithmic size in subpolynomial time}}, doi = {10.1137/1.9781611978971.25}, volume = {2026}, year = {2026}, } @article{21532, abstract = {Recent research in nanophotonics for scintillation-based imaging has demonstrated promising improvements in scintillator performance. In parallel, advances in nanophotonics have enabled wavefront control through metasurfaces, a capability that has transformed fields such as microscopy by allowing tailored control of optical propagation. This naturally raises the following question, which we address in this Perspective: can wavefront-control strategies be leveraged to improve scintillation-based imaging? To answer this question, we explore nanophotonic- and metasurface-enabled wavefront control in scintillators to mitigate image blurring arising from their intrinsically diffuse light emission. While depth-of-field extension in scintillation faces fundamental limitations absent in microscopy, this approach reveals promising avenues, including stacked scintillators, selective spatial-frequency enhancement, and X-ray energy-dependent imaging. These results clarify the key distinctions in adapting wavefront engineering to scintillation and its potential to enable tailored detection strategies.}, author = {Chen, Joshua and Vaidya, Sachin and Pajovic, Simo and Choi, Seou and Michaels, William and Martin-Monier, Louis and Hu, Juejun and Cogswell, Carol and Roques-Carmes, Charles and Soljačić, Marin}, issn = {2330-4022}, journal = {ACS Photonics}, number = {7}, pages = {1757–1766}, publisher = {American Chemical Society}, title = {{Wavefront engineering for scintillation-based imaging}}, doi = {10.1021/acsphotonics.5c03124}, volume = {13}, year = {2026}, } @article{21748, abstract = {Cells are defined by lipid membranes that differ in their structure across the tree of life. While the membranes of most bacteria and eukaryotes consist of single-headed bilayer lipids, the membranes of archaea are composed of mixtures of single-headed bilayer lipids and double-headed bolalipids. Archaeal bolalipids can adopt straight or u-shaped conformations, enabling them—together with bilayer lipids—to control whether membranes form bilayer or monolayer structures. Yet, the physical principles governing archaeal membranes remain largely unexplored, especially how membrane structure couples to externally imposed curvature during membrane remodeling. Here, we perform coarse-grained molecular dynamics simulations of toroidal vesicles to systematically probe the effects of all relevant combinations of mean and Gaussian curvatures on shape stability and lipid organization. We find that soft bilayer membranes can sustain all curvatures induced, whereas rigid bolalipid monolayer membranes either transition to different vesicle shapes or rupture. Bilayer-mimicking u-shaped bolalipids and bilayer lipids are spatially accumulated in regions of high mean membrane curvature independent of Gaussian curvature. Our work identifies curvature–composition coupling as a physical signature of archaeal membrane remodeling.}, author = {Frey, Felix F and Santana de Freitas Amaral, Miguel and Šarić, Anđela}, issn = {1089-7690}, journal = {Journal of Chemical Physics}, number = {14}, publisher = {AIP Publishing}, title = {{Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid organization}}, doi = {10.1063/5.0325170}, volume = {164}, year = {2026}, } @article{21747, abstract = {Entanglement does not always require one particle per party. It was predicted some 30 years ago that a single photon traversing a beam splitter could violate a Bell inequality. Although initially debated, single-photon nonlocality was eventually demonstrated via homodyne measurements. Here, we present an alternate realization that avoids the complexity of homodyne measurements and potential loopholes in their implementation. We violate a Bell inequality by performing joint measurements on two copies of the same single-photon entangled state, where one photon acts as a phase reference for the other, making it self-referential. We observe CHSH parameters of 2.71 = 0.09 and 2.23 = 0.07, depending on the joint measurements implemented. This offers a perspective on single-photon nonlocality and a more accessible experimental route, potentially applicable to general mode-entangled states in diverse platforms.}, author = {Kun, Daniel and Strömberg, Karl T and Dakić, Borivoje and Walther, Philip and Rozema, Lee A.}, issn = {2334-2536}, journal = {Optica}, number = {4}, pages = {745--751}, publisher = {Optica Publishing Group}, title = {{Testing single-photon entanglement using self-referential measurements}}, doi = {10.1364/OPTICA.586172}, volume = {13}, year = {2026}, } @article{21798, abstract = {Phase singularities—points carrying quantized topological charge—are universal features found across diverse wave systems from superfluids and superconductors to acoustic and optical fields1,2,3,4. Ensembles of these singularities exhibit distance correlations resembling particles in liquids5,6,7,8, extensively studied for their role in exotic material phases9,10,11. By contrast, the full correlations in phase space that govern the system evolution have remained unexplored and experimentally inaccessible. Here we directly measure the ultrafast dynamics of optical singularity ensembles, capturing their full phase-space correlations, presenting the joint distance–velocity distribution. Our observations show a breakdown of the particle-singularity analogy12: phase singularities accelerate towards formally divergent velocities in the moment before annihilation7,13,14, indicated by measurements of velocities exceeding the speed of light. These apparent superluminal velocities are paradoxically amplified by the slow group velocity of hyperbolic phonon polaritons in our material platform, hexagonal boron nitride membranes15,16,17,18,19. We demonstrate these phenomena using combined hardware and algorithmic advances in ultrafast electron microscopy18,20,21,22,23,24,25, achieving spatial and temporal resolutions, each an order of magnitude below the polaritonic wavelength and cycle period. Our findings deepen our understanding of phase singularities and their universality, enabling to probe topological defect dynamics at previously unattainable timescales.}, author = {Bucher, T. and Gorlach, A. and Niedermayr, A. and Yan, Q. and Nahari, H. and Wang, K. and Ruimy, R. and Adiv, Y. and Yannai, M. and Abudi, T. L. and Janzen, E. and Spaegele, C. and Roques-Carmes, Charles and Edgar, J. H. and Koppens, F. H. L. and Vanacore, G. M. and H. Sheinfux, H. and Tsesses, S. and Kaminer, I.}, issn = {1476-4687}, journal = {Nature}, number = {8107}, pages = {920--926}, publisher = {Springer Nature}, title = {{Superluminal correlations in ensembles of optical phase singularities}}, doi = {10.1038/s41586-026-10209-z}, volume = {651}, year = {2026}, } @misc{21800, abstract = {LAMMPS input scripts to simulate toroidal vesicles composed of pure bolalipid membranes and archaeal mixture membranes for the following publication: "Cracking donuts and sorting lipids: geometry controls archaeal membrane stability and lipid organization" by Felix Frey, Miguel Amaral, and Andela Saric.}, author = {Frey, Felix F and Santana de Freitas Amaral, Miguel and Šarić, Anđela}, publisher = {Zenodo}, title = {{Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid organization}}, doi = {10.5281/ZENODO.18772086}, year = {2026}, } @article{21750, abstract = {Liquid-like superionic conductors, with highly mobile ions in a rigid framework, offer intrinsically low lattice thermal conductivity without compromising electronic transport. Argyrodite-type Ag8SnSe6 exhibits a melt-like Ag sublattice that drives lattice thermal conductivity (κL) below 0.2 watts per meter per kelvin, yet its low carrier concentration limits the power factor. Here, interstitial Ag atoms raise the Fermi level into the conduction band, substantially increasing the electron concentration. Simultaneously, the formation of a secondary Ag2Se phase generates lattice distortions that enhance phonon scattering. A pronounced mismatch between electronic (~200 nanometers) and phononic (~0.22 nanometers) mean free paths decouples charge and heat transport, enabling concurrent suppression of κL and retention of high electrical conductivity. This coupled electronic-phononic modulation yields a record ZT of 0.72 at ambient temperature and a peak ZT of 1.1 at 735 kelvins, with an average ZTavg of 0.72 over 320 to 735 kelvins. A unicouple device achieves 6.3% efficiency under a 357-kelvin gradient, highlighting a practical strategy for high-performance midtemperature thermoelectrics.}, author = {Li, Mengyao and Zhao, Xueke and Zhang, Yu and Yu, Jing and Liu, Xuyang and Jia, Mochen and Song, Hongzhang and Wang, Dongyang and Arbiol, Jordi and Ibáñez, Maria and Shan, Chongxin and Cabot, Andreu and Wang, Ziyu}, issn = {2375-2548}, journal = {Science Advances}, number = {15}, publisher = {AAAS}, title = {{Electronic-phononic decoupling and Fermi-level tuning enable high thermoelectric performance in Ag8SnSe6}}, doi = {10.1126/sciadv.aec9073}, volume = {12}, year = {2026}, } @article{21751, abstract = {We define a certain class of simple varieties over a field k by a constructive recipe and show how to control their (equivariant) truncating invariants. Consequently, we prove that on simple varieties: (i) if k = k and char k = p, the p-adic cyclotomic trace is an equivalence; (ii) if k = Q, the Goodwillie–Jones trace is an isomorphism in degree zero; (iii) we can control homotopy invariant K-theory KH, which is equivariantly formal and determined by its topological counterparts. Simple varieties are quite special, but encompass important singular examples appearing in geometric representation theory. We, in particular, show that both finite and affine Schubert varieties for GLn lie in this class, so all the above results hold for them. }, author = {Löwit, Jakub}, issn = {1687-0247}, journal = {International Mathematics Research Notices}, number = {7}, publisher = {Oxford University Press}, title = {{Equivariant localizing invariants of simple varieties}}, doi = {10.1093/imrn/rnag058}, volume = {2026}, year = {2026}, } @article{21749, abstract = {The collagen triple helix assembles hierarchically into bundled oligomers, solvated networks, and fibers. Synthetic peptide assemblies, driven by supramolecular interactions, can form single triple helices through intrahelical amino acid pairs; however, the principles guiding interhelical associations into higher-order structures remain unclear. Here, we incorporate cation−π and electrostatic charge pairs to probe interhelical interactions and elucidate the mechanisms driving triple helix assembly into fibrils, nanotubes, and nanosheets. Introducing cation−π pairs into a fibrillating collagen mimetic resulted in D-periodic fibrils with pH-sensitive gelation. By alternating the presentation of electrostatic and cation−π pairs, the assembly of another D-periodic fibril featuring inner and outer triple-helical layers was resolved by cryo electron microscopy to a resolution of 8 Å. At physiological pH, antiparallel association of these triple helices leads to the formation of nanotubes. The packing behavior of triple helices correlates with the interhelical interactions, where parallel associations favor fibril formation and antiparallel interactions drive nanotube and nanosheet assembly. These self-assembling triple-helical peptides demonstrate how packing of higher-order structures can be tailored with supramolecular interactions and establish the relationship of different hierarchical collagen-mimetic assemblies as pH-dependent.}, author = {Cole, Carson C. and Kreutzberger, Mark A.B. and Klein, Kevin and Cahue, Kiana A. and Pogostin, Brett H. and Farsheed, Adam C. and Swain, Joseph W.R. and Bui, Thi H. and Dey, Arghadip and Makhoul, Jonathan T. and Dubackic, Marija and Pal, Antara and Olsson, Ulf and Šarić, Anđela and Egelman, Edward H. and Hartgerink, Jeffrey D.}, issn = {1526-4602}, journal = {Biomacromolecules}, number = {4}, pages = {2956--2965}, publisher = {American Chemical Society}, title = {{Supramolecular assembly of collagen-mimetic eptide D-periodic fibrils and nanoassemblies}}, doi = {10.1021/acs.biomac.6c00345}, volume = {27}, year = {2026}, } @article{21763, abstract = {Reactive oxygen species (ROS) have been implicated in multiple signaling processes in plants, but the underlying mechanisms and roles remain enigmatic. In this study, we developed a method of live imaging of apoplastic ROS at the root surface. Distinct signals, including auxin, extracellular adenosine triphosphate, and rapid alkalinization factor 1 peptide, induce cytosolic calcium transients and apoplastic ROS bursts. Genetic and optogenetic manipulations of Arabidopsis identified calcium transients as necessary and sufficient for ROS bursts through activation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases RBOHC and RBOHF. Apoplastic ROS bursts are not required, but they do limit gravity-induced root bending. Root bending is sensed by the stretch-activated calcium channel MCA1, leading to NADPH oxidase activation. The resulting ROS production stiffens cell walls to facilitate soil penetration. Apoplastic ROS thus provides a means to balance tissue flexibility and stiffness to navigate soil.}, author = {Kulich, Ivan and Vladimirtsev, Dmitrii and Randuch, Marek and Gao, Shiqiang and Citterico, Matteo and Konrad, Kai R. and Nagel, Georg and Wrzaczek, Michael and Cascaro, Léa and Vinet, Pauline and Durand, Pauline and Asnacios, Atef and Verma, Lokesh and Bennett, Malcolm J. and Pandey, Bipin K. and Friml, Jiří}, issn = {1095-9203}, journal = {Science}, number = {6795}, pages = {296--300}, publisher = {AAAS}, title = {{Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation}}, doi = {10.1126/science.adu8197}, volume = {392}, year = {2026}, } @article{21777, abstract = {The advantageous characteristics attributed to the 19F nucleus have made it a popular target for nuclear magnetic resonance (NMR) once again in recent years. Aside from solution NMR, an increasing number of studies have been conducted applying solid-state magic-angle spinning (MAS) NMR to fluorine-labelled samples. Here, the high chemical shift anisotropy and strong dipolar couplings can be utilised to get structural insights into proteins and measure long distances. Despite increasing popularity and promising benefits, the sensitivity of biomolecular 19F MAS NMR often suffers from slow longitudinal T1 relaxation and therefore long recycle delays. In this work, we expand paramagnetic doping, an approach commonly used to reduce proton T1 relaxation times, to 19F-labelled biological samples. We study the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F T1 and T2, and 13C T1 and T2 relaxation in a [5-19F13C]-tryptophan-labelled protein via 19F-detected MAS NMR experiments. The observed paramagnetic relaxation enhancement substantially reduces measurement times of 19F MAS NMR experiments without compromising resolution. Additionally, we report the chemical shift assignments of all four fluorotryptophan signals in the 12×39 kDa-large protein TET2 using a mutagenesis approach.}, author = {Becker, Lea Marie and Toscano, Giorgia and Kapitonova, Anna and Singh, Rajkumar and Guillerm, Undina and Lichtenecker, Roman J. and Schanda, Paul}, issn = {2699-0016}, journal = {Magnetic Resonance}, number = {1}, pages = {29--37}, publisher = {Copernicus Publications}, title = {{Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants}}, doi = {10.5194/mr-7-29-2026}, volume = {7}, year = {2026}, } @article{21780, abstract = {It is predicted that half or more of all cataclysmic variables (CVs) should have evolved past the period minimum and now exist as so-called period bouncers where a white dwarf should be accreting from a Roche lobe filling substellar companion. However, this prediction stands in stark contrast to observations, where only a few per cent of CVs are found in this evolutionary phase. A potential solution to this discrepancy is that a magnetic field emerges from within the white dwarf after the system has reached the period minimum. The transfer of angular momentum from the spin of the white dwarf into the orbit then pushes the two stars apart, detaching them for potentially billions of years. Here we present the discovery of ZTF J021804.16+071152.93, a detached 0.69 +- 0.01 M⁠, 19 MG magnetic white dwarf plus 37 +- 5MJup brown dwarf binary with an orbital period of 1.7 h. The kinematics of the system indicate that it is a high probability member of the Galactic thick disc. However, this strongly disagrees with the much younger age of the system obtained from the white dwarf parameters, implying that the system may have been accreting in the past. This system is therefore consistent with having detached as a result of the emergence of the magnetic field of the white dwarf when the system was still mass transferring, and may represent the ultimate fate for many (perhaps even most) CVs.}, author = {Parsons, S. G. and Brown, A. J. and Casewell, S. L. and Littlefair, S. P. and van Roestel, Joannes C and Rebassa-Mansergas, A. and Murillo-Ojeda, R. and Zorotovic, M. and Schreiber, M. R. and Bagnulo, S. and Stroet, M. A. and Castro Segura, N. and Dhillon, V. S. and Dyer, M. J. and Garbutt, J. A. and Green, M. J. and Jarvis, D. and Kennedy, M. R. and Kerry, P. and Mccormac, J. and Munday, J. and Pelisoli, I. and Pike, E. and Sahman, D. I. and Yates, A.}, issn = {1365-2966}, journal = {Monthly Notices of the Royal Astronomical Society}, number = {4}, publisher = {Oxford University Press}, title = {{ZTF J021804.16+071152.93: A dead cataclysmic variable and potential solution to the missing period bouncer cataclysmic variables}}, doi = {10.1093/mnras/stag521}, volume = {547}, year = {2026}, } @article{21779, abstract = {Acidomycin is an anti-mycobacterial antibiotic with a unique mode of action, targeting the biotin biosynthesis pathway. Despite being highly active against mycobacteria in vitro, its development as an anti-tubercular agent has been hindered due to suboptimal pharmacokinetics. Engineering of the acidomycin biosynthesis may yield new analogues with improved pharmacological properties. Here, we describe the identification of the acidomycin biosynthetic gene cluster (BGC) in a Streptomyces bacterium isolated from the rhizosphere of Edelweiss. Notably, the acidomycin BGC is located in proximity to the genes for the biosynthesis of stravidins, secondary metabolites targeting a different enzyme in the biotin biosynthesis pathway, and two genes for streptavidins, proteins that strongly bind and sequester biotin. The identity of the acidomycin BGC was confirmed via both gene knock-out and heterologous expression, which suggested that the fatty acid required for the formation of acidomycin's acyl chain is most likely scavenged from the biotin biosynthesis pathway. CRISPR/Cas9-assisted knock-out of the cytochrome P450-encoding gene in the acidomycin BGC resulted in a significant decrease in its yield but did not abrogate the biosynthesis completely.}, author = {Vignolle, Anna and Zehl, Martin and Garzón, Jaime Felipe Guerrero and Schneider, Olha and Gafriller, Johannes and Grienke, Ulrike and Kirkegaard, Rasmus H. and Zotchev, Sergey B.}, issn = {1751-7915}, journal = {Microbial Biotechnology}, number = {4}, publisher = {Wiley}, title = {{Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin}}, doi = {10.1111/1751-7915.70357}, volume = {19}, year = {2026}, } @article{21776, abstract = {Pyridyl motifs equipped with N-substituents can be powerful ligands for catalysis, yet their broader adoption is limited by the lack of a practical method to prepare these scaffolds. We report a modular, robust, and versatile Buchwald–Hartwig amination protocol that enables the rapid synthesis of bipyridine, phenanthroline, terpyridine, and pybox ligands bearing dialkylamine, diarylamine, and heteroaromatic N-substituents. These conditions streamline ligand library synthesis and will facilitate systematic studies in catalysis and related applications.}, author = {Petrik, Adam and Bena, Aleksander and Baunis, Haralds and Kelch, Riley M. and Yoon, Tehshik P. and Pieber, Bartholomäus}, issn = {1615-4169}, journal = {Advanced Synthesis & Catalysis}, number = {9}, publisher = {Wiley}, title = {{Facile access to N-substituted pyridyl ligands}}, doi = {10.1002/adsc.70417}, volume = {368}, year = {2026}, } @article{21781, abstract = {Given a set A of n points (vertices) in general position in the plane, the complete geometric graph Kn[A] consists of all (n2) segments (edges) between the elements of A. It is known that the edge set of every complete geometric graph on n vertices can be partitioned into O(n3∕2) crossing-free paths (or matchings). We strengthen this result under various additional assumptions on the point set. In particular, we prove that for a set A of n randomly selected points, uniformly distributed in [0,1]2, with probability tending to 1 as n→∞, the edge set of Kn[A] can be covered by O(nlogn) crossing-free paths and by O(n√logn) crossing-free matchings. On the other hand, we construct n-element point sets such that covering the edge set of Kn[A] requires a quadratic number of monotone paths.}, author = {Dumitrescu, Adrian and Pach, János and Saghafian, Morteza and Scott, Alex}, issn = {2996-220X}, journal = {Combinatorics and Number Theory}, number = {1}, pages = {73--82}, publisher = {Mathematical Sciences Publishers}, title = {{Covering complete geometric graphs by monotone paths}}, doi = {10.2140/cnt.2026.15.73}, volume = {15}, year = {2026}, } @article{21753, abstract = {The origin(s) of life (OoL), which has puzzled scientists for centuries, remains a major scientific challenge in the 21st century. Understanding the processes relevant to the OoL demands theoretical frameworks that can connect processes across scales, from microscopic dynamics to emergent levels of organization. While experimental studies generate a wealth of data, theoretical and computational approaches provide the structure necessary to interpret and generalize these findings. In Part 1, we examined the most widely used experimental techniques in the field. Here, we focus on the mathematical, physical, and computational techniques used to model phenomena relevant to life’s origin(s). We discuss methods ranging from quantum chemistry and molecular dynamics to chemical reaction networks, autocatalysis, and evolutionary modeling, as well as information-theoretic and phylogenetic approaches that link chemical and biological organization. We further highlight emerging trends such as synthetic biology, omics-based methods, and laboratory automation as novel points of contact for theory-experiment integration. Ultimately, we aim to provide an educational tool that can facilitate more post-disciplinary collaborations in OoL research by helping scientists understand what they can do about the problem of life’s origins, rather than telling them how to think about it.}, author = {Asche, Silke and Bautista, Carla and Blanco, Celia and Boulesteix, David and Champagne-Ruel, Alexandre and Mathis, Cole and Markovitch, Omer and Peng, Zhen and Dass, Avinash Vicholous and Adams, Alyssa and Camprubi, Eloi and Colizzi, Enrico Sandro and Colón-Santos, Stephanie and Dromiack, Hannah and Erastova, Valentina and Garcia, Amanda and Grimaud, Ghjuvan and Halpern, Aaron and Harrison, Stuart A. and Jordan, Seán F. and Jia, Tony Z. and Kahana, Amit and Kolchinsky, Artemy and Moron-Garcia, Odin and Mizuuchi, Ryo and Nan, Jingbo and Orlova, Yuliia and Pearce, Ben K.D. and Paschek, Klaus and Preiner, Martina and Pinna, Silvana and Rodríguez-Román, Eduardo and Schwander, Loraine and Sharma, Siddhant and Smith, Harrison B. and Vieira, Andrey and Xavier, Joana C.}, issn = {2666-3864}, journal = {Cell Reports Physical Science}, number = {4}, publisher = {Elsevier}, title = {{What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends}}, doi = {10.1016/j.xcrp.2026.103211}, volume = {7}, year = {2026}, }