[{"day":"13","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"title":"A small satellite version of a soft x-ray polarimeter","article_processing_charge":"No","publication_identifier":{"isbn":["978-151063675-0"],"eissn":["1996-756X"]},"doi":"10.1117/12.2562811","publisher":"SPIE","extern":"1","conference":{"end_date":"2020-12-18","location":"Virtual","start_date":"2020-12-14","name":"Astronomical Telescopes + Instrumentation"},"date_published":"2020-12-13T00:00:00Z","_id":"15228","quality_controlled":"1","article_number":"114442Y","volume":11444,"month":"12","year":"2020","publication_status":"published","author":[{"first_name":"Herman L.","last_name":"Marshall","full_name":"Marshall, Herman L."},{"first_name":"Sarah","last_name":"Heine","full_name":"Heine, Sarah"},{"full_name":"Garner, Alan","last_name":"Garner","first_name":"Alan"},{"last_name":"Gullikson","first_name":"Eric","full_name":"Gullikson, Eric"},{"full_name":"Guenther, Moritz","first_name":"Moritz","last_name":"Guenther"},{"first_name":"Christopher","last_name":"Leitz","full_name":"Leitz, Christopher"},{"first_name":"Rebecca","last_name":"Masterson","full_name":"Masterson, Rebecca"},{"full_name":"Miller, Eric","last_name":"Miller","first_name":"Eric"},{"last_name":"Zhang","first_name":"William","full_name":"Zhang, William"},{"last_name":"Boissay Malaquin","first_name":"Rozenn","full_name":"Boissay Malaquin, Rozenn"},{"last_name":"Caiazzo","first_name":"Ilaria","orcid":"0000-0002-4770-5388","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","full_name":"Caiazzo, Ilaria"},{"first_name":"Deepto","last_name":"Chakrabarty","full_name":"Chakrabarty, Deepto"},{"full_name":"Davidson, Rosemary","first_name":"Rosemary","last_name":"Davidson"},{"last_name":"Gallo","first_name":"Luigi","full_name":"Gallo, Luigi"},{"full_name":"Heilmann, Ralf K.","last_name":"Heilmann","first_name":"Ralf K."},{"last_name":"Heyl","first_name":"Jeremy","full_name":"Heyl, Jeremy"},{"full_name":"Kara, Erin","last_name":"Kara","first_name":"Erin"},{"first_name":"Alan","last_name":"Marscher","full_name":"Marscher, Alan"},{"full_name":"Schulz, Norbert","last_name":"Schulz","first_name":"Norbert"}],"intvolume":" 11444","date_updated":"2024-04-08T06:58:50Z","arxiv":1,"citation":{"chicago":"Marshall, Herman L., Sarah Heine, Alan Garner, Eric Gullikson, Moritz Guenther, Christopher Leitz, Rebecca Masterson, et al. “A Small Satellite Version of a Soft X-Ray Polarimeter.” In Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray, Vol. 11444. SPIE, 2020. https://doi.org/10.1117/12.2562811.","ama":"Marshall HL, Heine S, Garner A, et al. A small satellite version of a soft x-ray polarimeter. In: Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray. Vol 11444. SPIE; 2020. doi:10.1117/12.2562811","ieee":"H. L. Marshall et al., “A small satellite version of a soft x-ray polarimeter,” in Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray, Virtual, 2020, vol. 11444.","ista":"Marshall HL, Heine S, Garner A, Gullikson E, Guenther M, Leitz C, Masterson R, Miller E, Zhang W, Boissay Malaquin R, Caiazzo I, Chakrabarty D, Davidson R, Gallo L, Heilmann RK, Heyl J, Kara E, Marscher A, Schulz N. 2020. A small satellite version of a soft x-ray polarimeter. Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray. Astronomical Telescopes + Instrumentation vol. 11444, 114442Y.","apa":"Marshall, H. L., Heine, S., Garner, A., Gullikson, E., Guenther, M., Leitz, C., … Schulz, N. (2020). A small satellite version of a soft x-ray polarimeter. In Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray (Vol. 11444). Virtual: SPIE. https://doi.org/10.1117/12.2562811","short":"H.L. Marshall, S. Heine, A. Garner, E. Gullikson, M. Guenther, C. Leitz, R. Masterson, E. Miller, W. Zhang, R. Boissay Malaquin, I. Caiazzo, D. Chakrabarty, R. Davidson, L. Gallo, R.K. Heilmann, J. Heyl, E. Kara, A. Marscher, N. Schulz, in:, Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray, SPIE, 2020.","mla":"Marshall, Herman L., et al. “A Small Satellite Version of a Soft X-Ray Polarimeter.” Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray, vol. 11444, 114442Y, SPIE, 2020, doi:10.1117/12.2562811."},"language":[{"iso":"eng"}],"publication":"Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray","oa_version":"Preprint","date_created":"2024-03-26T10:36:20Z","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2012.02829"}],"type":"conference","abstract":[{"lang":"eng","text":"We describe a new implementation of a broad-band soft X-ray polarimeter, substantially based on a previous design. This implementation, the Pioneer Soft X-ray Polarimeter (PiSoX) is a SmallSat, designed for NASA’s call for Astrophysics Pioneers, small missions that could be CubeSats, balloon experiments, or SmallSats. As in REDSoX, the grating arrangement is designed optimally for the purpose of polarimetry with broad-band focussing optics by matching the dispersion of the spectrometer channels to laterally graded multilayers (LGMLs). The system can achieve polarization modulation factors over 90%. For PiSoX, the optics are lightweight Si mirrors in a one-bounce parabolic configuration. High efficiency, blazed gratings from opposite sectors are oriented to disperse to a LGML forming a channel covering the wavelength range from 35 Å to 75 Å (165 - 350 eV). Upon satellite rotation, the intensities of the dispersed spectra, after reflection and polarizing by the LGMLs, give the three Stokes parameters needed to determine a source’s linear polarization fraction and orientation. The design can be extended to higher energies as LGMLs are developed further. We describe examples of the potential scientific return from instruments based on this design."}],"status":"public","external_id":{"arxiv":["2012.02829"]}},{"type":"journal_article","publication":"microPublication Biology","date_created":"2025-03-07T08:21:51Z","oa_version":"Published Version","external_id":{"pmid":["33005885"]},"has_accepted_license":"1","status":"public","language":[{"iso":"eng"}],"article_type":"original","DOAJ_listed":"1","citation":{"chicago":"Kazatskaya, Anna, Lisa Yuan, Niko Paresh Amin-Wetzel, Alison Philbrook, Mario de Bono, and Piali Sengupta. “The URX Oxygen-Sensing Neurons in C. Elegans Are Ciliated.” MicroPublication Biology. Caltech Library, 2020. https://doi.org/10.17912/MICROPUB.BIOLOGY.000303.","mla":"Kazatskaya, Anna, et al. “The URX Oxygen-Sensing Neurons in C. Elegans Are Ciliated.” MicroPublication Biology, vol. 2020, no. 9, 303, Caltech Library, 2020, doi:10.17912/MICROPUB.BIOLOGY.000303.","short":"A. Kazatskaya, L. Yuan, N.P. Amin-Wetzel, A. Philbrook, M. de Bono, P. Sengupta, MicroPublication Biology 2020 (2020).","apa":"Kazatskaya, A., Yuan, L., Amin-Wetzel, N. P., Philbrook, A., de Bono, M., & Sengupta, P. (2020). The URX oxygen-sensing neurons in C. elegans are ciliated. MicroPublication Biology. Caltech Library. https://doi.org/10.17912/MICROPUB.BIOLOGY.000303","ama":"Kazatskaya A, Yuan L, Amin-Wetzel NP, Philbrook A, de Bono M, Sengupta P. The URX oxygen-sensing neurons in C. elegans are ciliated. microPublication Biology. 2020;2020(9). doi:10.17912/MICROPUB.BIOLOGY.000303","ieee":"A. Kazatskaya, L. Yuan, N. P. Amin-Wetzel, A. Philbrook, M. de Bono, and P. Sengupta, “The URX oxygen-sensing neurons in C. elegans are ciliated,” microPublication Biology, vol. 2020, no. 9. Caltech Library, 2020.","ista":"Kazatskaya A, Yuan L, Amin-Wetzel NP, Philbrook A, de Bono M, Sengupta P. 2020. The URX oxygen-sensing neurons in C. elegans are ciliated. microPublication Biology. 2020(9), 303."},"OA_place":"publisher","intvolume":" 2020","ddc":["570"],"date_updated":"2025-03-11T08:30:41Z","OA_type":"gold","author":[{"last_name":"Kazatskaya","first_name":"Anna","full_name":"Kazatskaya, Anna"},{"first_name":"Lisa","last_name":"Yuan","full_name":"Yuan, Lisa"},{"id":"E95D3014-9D8C-11E9-9C80-D2F8E5697425","full_name":"Amin-Wetzel, Niko Paresh","last_name":"Amin-Wetzel","first_name":"Niko Paresh"},{"last_name":"Philbrook","first_name":"Alison","full_name":"Philbrook, Alison"},{"full_name":"de Bono, Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","last_name":"de Bono","orcid":"0000-0001-8347-0443","first_name":"Mario"},{"full_name":"Sengupta, Piali","last_name":"Sengupta","first_name":"Piali"}],"pmid":1,"year":"2020","publication_status":"published","file_date_updated":"2025-03-11T08:27:40Z","volume":2020,"issue":"9","month":"09","_id":"19306","date_published":"2020-09-20T00:00:00Z","quality_controlled":"1","article_number":"303","doi":"10.17912/MICROPUB.BIOLOGY.000303","acknowledgement":"We thank Maureen Barr, Martin Harterink, Max Heiman and Inna Nechipurenko for reagents, the Caenorhabditis Genetics Center for strains, and the Sengupta lab for comments and advice.\r\nThis work was funded in part by the NIH (R35 GM122463 – P.S., and F32 DC018453 – A.P.), and the EMBO (ALTF 302-2019 – N.A-W.).","file":[{"creator":"dernst","relation":"main_file","access_level":"open_access","date_created":"2025-03-11T08:27:40Z","content_type":"application/pdf","file_size":1486239,"success":1,"checksum":"14a7cad20775521ce85e0e3c77aa7936","file_name":"2020_MicroPublBio_Kazatskaya.pdf","file_id":"19383","date_updated":"2025-03-11T08:27:40Z"}],"publisher":"Caltech Library","article_processing_charge":"Yes","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["2578-9430"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","license":"https://creativecommons.org/licenses/by/4.0/","title":"The URX oxygen-sensing neurons in C. elegans are ciliated","oa":1,"day":"20","department":[{"_id":"MaDe"}]},{"_id":"5681","date_published":"2020-06-01T00:00:00Z","quality_controlled":"1","acknowledgement":"This work was partially supported by JSPS Grant-in-Aid forYoung Scientists (Start-up) 16H07410, the ERC StartingGrantsrealFlow(StG-2015-637014) andBigSplash(StG-2014-638176). This research was supported by the Scientific Ser-vice Units (SSU) of IST Austria through resources providedby Scientific Computing. We would like to express my grati-tude to Nobuyuki Umetani and Tomas Skrivan for insight-ful discussion.","doi":"10.1109/TVCG.2018.2883628","isi":1,"file":[{"file_size":21910098,"date_updated":"2020-10-08T08:34:53Z","file_id":"8626","file_name":"preprint.pdf","success":1,"checksum":"8d4c55443a0ee335bb5bb652de503042","access_level":"open_access","relation":"main_file","creator":"wojtan","date_created":"2020-10-08T08:34:53Z","content_type":"application/pdf"}],"publisher":"IEEE","article_processing_charge":"No","publication_identifier":{"eissn":["1941-0506"],"issn":["1077-2626"]},"day":"01","department":[{"_id":"ChWo"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Simulating liquids on dynamically warping grids","oa":1,"language":[{"iso":"eng"}],"article_type":"original","citation":{"short":"I. Hikaru, C. Wojtan, N. Thuerey, T. Igarashi, R. Ando, IEEE Transactions on Visualization and Computer Graphics 26 (2020) 2288–2302.","mla":"Hikaru, Ibayashi, et al. “Simulating Liquids on Dynamically Warping Grids.” IEEE Transactions on Visualization and Computer Graphics, vol. 26, no. 6, IEEE, 2020, pp. 2288–302, doi:10.1109/TVCG.2018.2883628.","ieee":"I. Hikaru, C. Wojtan, N. Thuerey, T. Igarashi, and R. Ando, “Simulating liquids on dynamically warping grids,” IEEE Transactions on Visualization and Computer Graphics, vol. 26, no. 6. IEEE, pp. 2288–2302, 2020.","ama":"Hikaru I, Wojtan C, Thuerey N, Igarashi T, Ando R. Simulating liquids on dynamically warping grids. IEEE Transactions on Visualization and Computer Graphics. 2020;26(6):2288-2302. doi:10.1109/TVCG.2018.2883628","ista":"Hikaru I, Wojtan C, Thuerey N, Igarashi T, Ando R. 2020. Simulating liquids on dynamically warping grids. IEEE Transactions on Visualization and Computer Graphics. 26(6), 2288–2302.","apa":"Hikaru, I., Wojtan, C., Thuerey, N., Igarashi, T., & Ando, R. (2020). Simulating liquids on dynamically warping grids. IEEE Transactions on Visualization and Computer Graphics. IEEE. https://doi.org/10.1109/TVCG.2018.2883628","chicago":"Hikaru, Ibayashi, Chris Wojtan, Nils Thuerey, Takeo Igarashi, and Ryoichi Ando. “Simulating Liquids on Dynamically Warping Grids.” IEEE Transactions on Visualization and Computer Graphics. IEEE, 2020. https://doi.org/10.1109/TVCG.2018.2883628."},"type":"journal_article","scopus_import":"1","date_created":"2018-12-16T22:59:21Z","oa_version":"Submitted Version","publication":"IEEE Transactions on Visualization and Computer Graphics","has_accepted_license":"1","status":"public","external_id":{"pmid":["30507534"],"isi":["000532295600014"]},"abstract":[{"text":"We introduce dynamically warping grids for adaptive liquid simulation. Our primary contributions are a strategy for dynamically deforming regular grids over the course of a simulation and a method for efficiently utilizing these deforming grids for liquid simulation. Prior work has shown that unstructured grids are very effective for adaptive fluid simulations. However, unstructured grids often lead to complicated implementations and a poor cache hit rate due to inconsistent memory access. Regular grids, on the other hand, provide a fast, fixed memory access pattern and straightforward implementation. Our method combines the advantages of both: we leverage the simplicity of regular grids while still achieving practical and controllable spatial adaptivity. We demonstrate that our method enables adaptive simulations that are fast, flexible, and robust to null-space issues. At the same time, our method is simple to implement and takes advantage of existing highly-tuned algorithms.","lang":"eng"}],"intvolume":" 26","ddc":["006"],"date_updated":"2025-07-10T11:52:55Z","pmid":1,"page":"2288-2302","author":[{"full_name":"Hikaru, Ibayashi","last_name":"Hikaru","first_name":"Ibayashi"},{"id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","full_name":"Wojtan, Christopher J","last_name":"Wojtan","first_name":"Christopher J","orcid":"0000-0001-6646-5546"},{"first_name":"Nils","last_name":"Thuerey","full_name":"Thuerey, Nils"},{"full_name":"Igarashi, Takeo","last_name":"Igarashi","first_name":"Takeo"},{"full_name":"Ando, Ryoichi","last_name":"Ando","first_name":"Ryoichi"}],"acknowledged_ssus":[{"_id":"ScienComp"}],"volume":26,"issue":"6","month":"06","year":"2020","publication_status":"published","file_date_updated":"2020-10-08T08:34:53Z"},{"arxiv":1,"ddc":["500"],"date_updated":"2025-06-12T07:27:20Z","intvolume":" 178","project":[{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"},{"grant_number":"716117","name":"Optimal Transport and Stochastic Dynamics","call_identifier":"H2020","_id":"256E75B8-B435-11E9-9278-68D0E5697425"},{"grant_number":"F06504","name":"Taming Complexity in Partial Differential Systems","call_identifier":"FWF","_id":"260482E2-B435-11E9-9278-68D0E5697425"}],"has_accepted_license":"1","external_id":{"arxiv":["1811.04572"],"isi":["000498933300001"],"pmid":["33223567"]},"status":"public","abstract":[{"lang":"eng","text":"We study dynamical optimal transport metrics between density matricesassociated to symmetric Dirichlet forms on finite-dimensional C∗-algebras. Our settingcovers arbitrary skew-derivations and it provides a unified framework that simultaneously generalizes recently constructed transport metrics for Markov chains, Lindblad equations, and the Fermi Ornstein–Uhlenbeck semigroup. We develop a non-nommutative differential calculus that allows us to obtain non-commutative Ricci curvature bounds, logarithmic Sobolev inequalities, transport-entropy inequalities, andspectral gap estimates."}],"type":"journal_article","corr_author":"1","publication":"Journal of Statistical Physics","scopus_import":"1","date_created":"2019-04-30T07:34:18Z","oa_version":"Published Version","language":[{"iso":"eng"}],"ec_funded":1,"article_type":"original","citation":{"ista":"Carlen EA, Maas J. 2020. Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems. Journal of Statistical Physics. 178(2), 319–378.","ama":"Carlen EA, Maas J. Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems. Journal of Statistical Physics. 2020;178(2):319-378. doi:10.1007/s10955-019-02434-w","ieee":"E. A. Carlen and J. Maas, “Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems,” Journal of Statistical Physics, vol. 178, no. 2. Springer Nature, pp. 319–378, 2020.","apa":"Carlen, E. A., & Maas, J. (2020). Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems. Journal of Statistical Physics. Springer Nature. https://doi.org/10.1007/s10955-019-02434-w","short":"E.A. Carlen, J. Maas, Journal of Statistical Physics 178 (2020) 319–378.","mla":"Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport and Functional Inequalities in Dissipative Quantum Systems.” Journal of Statistical Physics, vol. 178, no. 2, Springer Nature, 2020, pp. 319–78, doi:10.1007/s10955-019-02434-w.","chicago":"Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport and Functional Inequalities in Dissipative Quantum Systems.” Journal of Statistical Physics. Springer Nature, 2020. https://doi.org/10.1007/s10955-019-02434-w."},"file_date_updated":"2020-07-14T12:47:28Z","publication_status":"published","year":"2020","month":"01","volume":178,"issue":"2","related_material":{"link":[{"url":"https://doi.org/10.1007/s10955-020-02671-4","relation":"erratum"}]},"author":[{"last_name":"Carlen","first_name":"Eric A.","full_name":"Carlen, Eric A."},{"full_name":"Maas, Jan","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0845-1338","first_name":"Jan","last_name":"Maas"}],"page":"319-378","pmid":1,"publisher":"Springer Nature","doi":"10.1007/s10955-019-02434-w","file":[{"relation":"main_file","creator":"dernst","access_level":"open_access","content_type":"application/pdf","date_created":"2019-12-23T12:03:09Z","file_size":905538,"checksum":"7b04befbdc0d4982c0ee945d25d19872","date_updated":"2020-07-14T12:47:28Z","file_id":"7209","file_name":"2019_JourStatistPhysics_Carlen.pdf"}],"isi":1,"quality_controlled":"1","_id":"6358","date_published":"2020-01-01T00:00:00Z","title":"Non-commutative calculus, optimal transport and functional inequalities in dissipative quantum systems","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JaMa"}],"day":"01","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["0022-4715"],"eissn":["1572-9613"]},"article_processing_charge":"Yes (via OA deal)"},{"publication_identifier":{"eissn":["1083-6489"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"No","oa":1,"title":"On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JaMa"}],"day":"16","article_number":"82","_id":"6359","date_published":"2020-07-16T00:00:00Z","quality_controlled":"1","publisher":"Institute of Mathematical Statistics","file":[{"content_type":"application/pdf","date_created":"2020-09-21T13:15:02Z","access_level":"open_access","creator":"dernst","relation":"main_file","file_name":"2020_EJournProbab_Dareiotis.pdf","file_id":"8549","date_updated":"2020-09-21T13:15:02Z","checksum":"8e7c42e72596f6889d786e8e8b89994f","success":1,"file_size":273042}],"doi":"10.1214/20-EJP479","isi":1,"author":[{"last_name":"Dareiotis","first_name":"Konstantinos","full_name":"Dareiotis, Konstantinos"},{"last_name":"Gerencser","first_name":"Mate","id":"44ECEDF2-F248-11E8-B48F-1D18A9856A87","full_name":"Gerencser, Mate"}],"publication_status":"published","file_date_updated":"2020-09-21T13:15:02Z","year":"2020","month":"07","volume":25,"abstract":[{"text":"The strong rate of convergence of the Euler-Maruyama scheme for nondegenerate SDEs with irregular drift coefficients is considered. In the case of α-Hölder drift in the recent literature the rate α/2 was proved in many related situations. By exploiting the regularising effect of the noise more efficiently, we show that the rate is in fact arbitrarily close to 1/2 for all α>0. The result extends to Dini continuous coefficients, while in d=1 also to all bounded measurable coefficients.","lang":"eng"}],"external_id":{"arxiv":["1812.04583"],"isi":["000550150700001"]},"status":"public","has_accepted_license":"1","publication":"Electronic Journal of Probability","date_created":"2019-04-30T07:40:17Z","oa_version":"Published Version","scopus_import":"1","type":"journal_article","citation":{"chicago":"Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of the Noise for the Euler-Maruyama Scheme with Irregular Drift.” Electronic Journal of Probability. Institute of Mathematical Statistics, 2020. https://doi.org/10.1214/20-EJP479.","apa":"Dareiotis, K., & Gerencser, M. (2020). On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/20-EJP479","ama":"Dareiotis K, Gerencser M. On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability. 2020;25. doi:10.1214/20-EJP479","ista":"Dareiotis K, Gerencser M. 2020. On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability. 25, 82.","ieee":"K. Dareiotis and M. Gerencser, “On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift,” Electronic Journal of Probability, vol. 25. Institute of Mathematical Statistics, 2020.","mla":"Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of the Noise for the Euler-Maruyama Scheme with Irregular Drift.” Electronic Journal of Probability, vol. 25, 82, Institute of Mathematical Statistics, 2020, doi:10.1214/20-EJP479.","short":"K. Dareiotis, M. Gerencser, Electronic Journal of Probability 25 (2020)."},"article_type":"original","language":[{"iso":"eng"}],"date_updated":"2023-10-16T09:22:50Z","ddc":["510"],"arxiv":1,"intvolume":" 25"},{"date_published":"2020-06-12T00:00:00Z","_id":"19807","quality_controlled":"1","extern":"1","publisher":"American Association for the Advancement of Science","doi":"10.1126/science.aay8413","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"article_processing_charge":"No","title":"h/e oscillations in interlayer transport of delafossites","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"12","status":"public","external_id":{"arxiv":["1902.07331"],"pmid":["32527829"]},"abstract":[{"lang":"eng","text":"Microstructures can be carefully designed to reveal the quantum phase of the wave-like nature of electrons in a metal. Here, we report phase-coherent oscillations of out-of-plane magnetoresistance in the layered delafossites PdCoO2 and PtCoO2. The oscillation period is equivalent to that determined by the magnetic flux quantum, h/e, threading an area defined by the atomic interlayer separation and the sample width, where h is Planck’s constant and e is the charge of an electron. The phase of the electron wave function appears robust over length scales exceeding 10 micrometers and persisting up to temperatures of T > 50 kelvin. We show that the experimental signal stems from a periodic field modulation of the out-of-plane hopping. These results demonstrate extraordinary single-particle quantum coherence lengths in delafossites."}],"type":"journal_article","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1902.07331","open_access":"1"}],"publication":"Science","date_created":"2025-06-10T09:11:34Z","scopus_import":"1","oa_version":"Preprint","language":[{"iso":"eng"}],"article_type":"original","citation":{"chicago":"Putzke, Carsten, Maja D. Bachmann, Philippa McGuinness, Elina Zhakina, Veronika Sunko, Marcin Konczykowski, Takashi Oka, et al. “H/e Oscillations in Interlayer Transport of Delafossites.” Science. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/science.aay8413.","ieee":"C. Putzke et al., “h/e oscillations in interlayer transport of delafossites,” Science, vol. 368, no. 6496. American Association for the Advancement of Science, pp. 1234–1238, 2020.","ista":"Putzke C, Bachmann MD, McGuinness P, Zhakina E, Sunko V, Konczykowski M, Oka T, Moessner R, Stern A, König M, Khim S, Mackenzie AP, Moll PJW. 2020. h/e oscillations in interlayer transport of delafossites. Science. 368(6496), 1234–1238.","ama":"Putzke C, Bachmann MD, McGuinness P, et al. h/e oscillations in interlayer transport of delafossites. Science. 2020;368(6496):1234-1238. doi:10.1126/science.aay8413","apa":"Putzke, C., Bachmann, M. D., McGuinness, P., Zhakina, E., Sunko, V., Konczykowski, M., … Moll, P. J. W. (2020). h/e oscillations in interlayer transport of delafossites. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aay8413","short":"C. Putzke, M.D. Bachmann, P. McGuinness, E. Zhakina, V. Sunko, M. Konczykowski, T. Oka, R. Moessner, A. Stern, M. König, S. Khim, A.P. Mackenzie, P.J.W. Moll, Science 368 (2020) 1234–1238.","mla":"Putzke, Carsten, et al. “H/e Oscillations in Interlayer Transport of Delafossites.” Science, vol. 368, no. 6496, American Association for the Advancement of Science, 2020, pp. 1234–38, doi:10.1126/science.aay8413."},"arxiv":1,"date_updated":"2025-06-10T11:27:54Z","intvolume":" 368","OA_place":"repository","OA_type":"green","author":[{"full_name":"Putzke, Carsten","last_name":"Putzke","first_name":"Carsten"},{"last_name":"Bachmann","first_name":"Maja D.","full_name":"Bachmann, Maja D."},{"last_name":"McGuinness","first_name":"Philippa","full_name":"McGuinness, Philippa"},{"full_name":"Zhakina, Elina","last_name":"Zhakina","first_name":"Elina"},{"orcid":"0000-0003-2724-3523","first_name":"Veronika","last_name":"Sunko","full_name":"Sunko, Veronika","id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3"},{"full_name":"Konczykowski, Marcin","first_name":"Marcin","last_name":"Konczykowski"},{"first_name":"Takashi","last_name":"Oka","full_name":"Oka, Takashi"},{"last_name":"Moessner","first_name":"Roderich","full_name":"Moessner, Roderich"},{"first_name":"Ady","last_name":"Stern","full_name":"Stern, Ady"},{"last_name":"König","first_name":"Markus","full_name":"König, Markus"},{"full_name":"Khim, Seunghyun","first_name":"Seunghyun","last_name":"Khim"},{"last_name":"Mackenzie","first_name":"Andrew P.","full_name":"Mackenzie, Andrew P."},{"first_name":"Philip J.W.","last_name":"Moll","full_name":"Moll, Philip J.W."}],"page":"1234-1238","pmid":1,"publication_status":"published","year":"2020","month":"06","volume":368,"issue":"6496"},{"article_number":"aaz0611","date_published":"2020-02-07T00:00:00Z","_id":"19812","quality_controlled":"1","publisher":"American Association for the Advancement of Science","doi":"10.1126/sciadv.aaz0611","extern":"1","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eissn":["2375-2548"]},"article_processing_charge":"Yes","day":"07","title":"Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"citation":{"chicago":"Sunko, Veronika, F. Mazzola, S. Kitamura, S. Khim, P. Kushwaha, O. J. Clark, M. D. Watson, et al. “Probing Spin Correlations Using Angle-Resolved Photoemission in a Coupled Metallic/Mott Insulator System.” Science Advances. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/sciadv.aaz0611.","ieee":"V. Sunko et al., “Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system,” Science Advances, vol. 6, no. 6. American Association for the Advancement of Science, 2020.","ista":"Sunko V, Mazzola F, Kitamura S, Khim S, Kushwaha P, Clark OJ, Watson MD, Marković I, Biswas D, Pourovskii L, Kim TK, Lee T-L, Thakur PK, Rosner H, Georges A, Moessner R, Oka T, Mackenzie AP, King PDC. 2020. Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. Science Advances. 6(6), aaz0611.","ama":"Sunko V, Mazzola F, Kitamura S, et al. Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. Science Advances. 2020;6(6). doi:10.1126/sciadv.aaz0611","apa":"Sunko, V., Mazzola, F., Kitamura, S., Khim, S., Kushwaha, P., Clark, O. J., … King, P. D. C. (2020). Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott insulator system. Science Advances. American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.aaz0611","short":"V. Sunko, F. Mazzola, S. Kitamura, S. Khim, P. Kushwaha, O.J. Clark, M.D. Watson, I. Marković, D. Biswas, L. Pourovskii, T.K. Kim, T.-L. Lee, P.K. Thakur, H. Rosner, A. Georges, R. Moessner, T. Oka, A.P. Mackenzie, P.D.C. King, Science Advances 6 (2020).","mla":"Sunko, Veronika, et al. “Probing Spin Correlations Using Angle-Resolved Photoemission in a Coupled Metallic/Mott Insulator System.” Science Advances, vol. 6, no. 6, aaz0611, American Association for the Advancement of Science, 2020, doi:10.1126/sciadv.aaz0611."},"article_type":"original","status":"public","external_id":{"arxiv":["1809.08972"],"pmid":["32128385"]},"has_accepted_license":"1","abstract":[{"lang":"eng","text":"A nearly free electron metal and a Mott insulating state can be thought of as opposite ends of the spectrum of possibilities for the motion of electrons in a solid. Understanding their interaction lies at the heart of the correlated electron problem. In the magnetic oxide metal PdCrO2, nearly free and Mott-localized electrons exist in alternating layers, forming natural heterostructures. Using angle-resolved photoemission spectroscopy, quantitatively supported by a strong coupling analysis, we show that the coupling between these layers leads to an “intertwined” excitation that is a convolution of the charge spectrum of the metallic layer and the spin susceptibility of the Mott layer. Our findings establish PdCrO2 as a model system in which to probe Kondo lattice physics and also open new routes to use the a priori nonmagnetic probe of photoemission to gain insights into the spin susceptibility of correlated electron materials."}],"type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1126/sciadv.aaz0611","open_access":"1"}],"date_created":"2025-06-10T09:14:20Z","publication":"Science Advances","scopus_import":"1","oa_version":"Published Version","OA_type":"gold","arxiv":1,"date_updated":"2025-06-10T13:12:09Z","OA_place":"publisher","intvolume":" 6","pmid":1,"author":[{"orcid":"0000-0003-2724-3523","first_name":"Veronika","last_name":"Sunko","full_name":"Sunko, Veronika","id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3"},{"full_name":"Mazzola, F.","last_name":"Mazzola","first_name":"F."},{"full_name":"Kitamura, S.","last_name":"Kitamura","first_name":"S."},{"last_name":"Khim","first_name":"S.","full_name":"Khim, S."},{"full_name":"Kushwaha, P.","last_name":"Kushwaha","first_name":"P."},{"full_name":"Clark, O. J.","last_name":"Clark","first_name":"O. J."},{"full_name":"Watson, M. D.","first_name":"M. D.","last_name":"Watson"},{"first_name":"I.","last_name":"Marković","full_name":"Marković, I."},{"first_name":"D.","last_name":"Biswas","full_name":"Biswas, D."},{"last_name":"Pourovskii","first_name":"L.","full_name":"Pourovskii, L."},{"first_name":"T. K.","last_name":"Kim","full_name":"Kim, T. K."},{"full_name":"Lee, T.-L.","first_name":"T.-L.","last_name":"Lee"},{"last_name":"Thakur","first_name":"P. K.","full_name":"Thakur, P. K."},{"last_name":"Rosner","first_name":"H.","full_name":"Rosner, H."},{"last_name":"Georges","first_name":"A.","full_name":"Georges, A."},{"full_name":"Moessner, R.","first_name":"R.","last_name":"Moessner"},{"first_name":"T.","last_name":"Oka","full_name":"Oka, T."},{"full_name":"Mackenzie, A. P.","first_name":"A. P.","last_name":"Mackenzie"},{"full_name":"King, P. D. C.","first_name":"P. D. C.","last_name":"King"}],"month":"02","volume":6,"issue":"6","publication_status":"published","year":"2020"},{"day":"24","title":"Controlled introduction of defects to delafossite metals by electron irradiation","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["2160-3308"]},"article_processing_charge":"Yes","publisher":"American Physical Society","doi":"10.1103/physrevx.10.021018","extern":"1","article_number":"021018","_id":"19823","date_published":"2020-04-24T00:00:00Z","quality_controlled":"1","month":"04","volume":10,"issue":"2","publication_status":"published","year":"2020","author":[{"id":"23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3","full_name":"Sunko, Veronika","last_name":"Sunko","first_name":"Veronika","orcid":"0000-0003-2724-3523"},{"first_name":"P. H.","last_name":"McGuinness","full_name":"McGuinness, P. H."},{"full_name":"Chang, C. S.","last_name":"Chang","first_name":"C. S."},{"first_name":"E.","last_name":"Zhakina","full_name":"Zhakina, E."},{"full_name":"Khim, S.","first_name":"S.","last_name":"Khim"},{"first_name":"C. E.","last_name":"Dreyer","full_name":"Dreyer, C. E."},{"first_name":"M.","last_name":"Konczykowski","full_name":"Konczykowski, M."},{"last_name":"Borrmann","first_name":"H.","full_name":"Borrmann, H."},{"full_name":"Moll, P. J. W.","last_name":"Moll","first_name":"P. J. W."},{"first_name":"M.","last_name":"König","full_name":"König, M."},{"full_name":"Muller, D. A.","last_name":"Muller","first_name":"D. A."},{"full_name":"Mackenzie, A. P.","last_name":"Mackenzie","first_name":"A. P."}],"OA_type":"gold","arxiv":1,"date_updated":"2025-06-10T13:08:51Z","OA_place":"publisher","intvolume":" 10","language":[{"iso":"eng"}],"citation":{"chicago":"Sunko, Veronika, P. H. McGuinness, C. S. Chang, E. Zhakina, S. Khim, C. E. Dreyer, M. Konczykowski, et al. “Controlled Introduction of Defects to Delafossite Metals by Electron Irradiation.” Physical Review X. American Physical Society, 2020. https://doi.org/10.1103/physrevx.10.021018.","ama":"Sunko V, McGuinness PH, Chang CS, et al. Controlled introduction of defects to delafossite metals by electron irradiation. Physical Review X. 2020;10(2). doi:10.1103/physrevx.10.021018","ista":"Sunko V, McGuinness PH, Chang CS, Zhakina E, Khim S, Dreyer CE, Konczykowski M, Borrmann H, Moll PJW, König M, Muller DA, Mackenzie AP. 2020. Controlled introduction of defects to delafossite metals by electron irradiation. Physical Review X. 10(2), 021018.","ieee":"V. Sunko et al., “Controlled introduction of defects to delafossite metals by electron irradiation,” Physical Review X, vol. 10, no. 2. American Physical Society, 2020.","apa":"Sunko, V., McGuinness, P. H., Chang, C. S., Zhakina, E., Khim, S., Dreyer, C. E., … Mackenzie, A. P. (2020). Controlled introduction of defects to delafossite metals by electron irradiation. Physical Review X. American Physical Society. https://doi.org/10.1103/physrevx.10.021018","short":"V. Sunko, P.H. McGuinness, C.S. Chang, E. Zhakina, S. Khim, C.E. Dreyer, M. Konczykowski, H. Borrmann, P.J.W. Moll, M. König, D.A. Muller, A.P. Mackenzie, Physical Review X 10 (2020).","mla":"Sunko, Veronika, et al. “Controlled Introduction of Defects to Delafossite Metals by Electron Irradiation.” Physical Review X, vol. 10, no. 2, 021018, American Physical Society, 2020, doi:10.1103/physrevx.10.021018."},"article_type":"original","DOAJ_listed":"1","external_id":{"arxiv":["2001.01471"]},"status":"public","abstract":[{"lang":"eng","text":"The delafossite metals PdCoO2, PtCoO2, and PdCrO2 are among the highest conductivity materials known, with low-temperature mean free paths of tens of microns in the best as-grown single crystals. A key question is whether these very low resistive scattering rates result from strongly suppressed backscattering due to special features of the electronic structure or are a consequence of highly unusual levels of crystalline perfection. We report the results of experiments in which high-energy electron irradiation was used to introduce point disorder to the Pd and Pt layers in which the conduction occurs. We obtain the cross section for formation of Frenkel pairs in absolute units, and cross-check our analysis with first-principles calculations of the relevant atomic displacement energies. We observe an increase of resistivity that is linear in defect density with a slope consistent with scattering in the unitary limit. Our results enable us to deduce that the as-grown crystals contain extremely low levels of in-plane defects of approximately 0.001%. This confirms that crystalline perfection is the most important factor in realizing the long mean free paths and highlights how unusual these delafossite metals are in comparison with the vast majority of other multicomponent oxides and alloys. We discuss the implications of our findings for future materials research."}],"main_file_link":[{"url":"https://doi.org/10.1103/PhysRevX.10.021018","open_access":"1"}],"type":"journal_article","publication":"Physical Review X","scopus_import":"1","oa_version":"Published Version","date_created":"2025-06-10T09:21:11Z"},{"quality_controlled":"1","_id":"19986","date_published":"2020-11-18T00:00:00Z","doi":"10.1017/9781108770750.008","file":[{"file_size":316681,"date_updated":"2025-09-23T12:03:09Z","file_id":"20380","file_name":"2020_ProbProgramming_Chatterjee.pdf","checksum":"28ece115e8d2d9263e253a598e7caef2","success":1,"access_level":"open_access","relation":"main_file","creator":"dernst","content_type":"application/pdf","date_created":"2025-09-23T12:03:09Z"}],"acknowledgement":"Krishnendu Chatterjee is supported by the Austrian Science Fund (FWF) NFN\r\nGrant No. S11407-N23 (RiSE/SHiNE), and COST Action GAMENET. Hongfei Fu\r\nis supported by the National Natural Science Foundation of China (NSFC) Grant\r\nNo. 61802254. Petr Novotný is supported by the Czech Science Foundation grant\r\nNo. GJ19-15134Y.","publisher":"Cambridge University Press","article_processing_charge":"No","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"eisbn":["9781108770750"],"isbn":["9781108488518"]},"day":"18","department":[{"_id":"KrCh"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Termination Analysis of Probabilistic Programs with Martingales","oa":1,"language":[{"iso":"eng"}],"citation":{"ieee":"K. Chatterjee, H. Fu, and P. Novotný, “Termination Analysis of Probabilistic Programs with Martingales,” in Foundations of Probabilistic Programming, Cambridge University Press, 2020, pp. 221–258.","ama":"Chatterjee K, Fu H, Novotný P. Termination Analysis of Probabilistic Programs with Martingales. In: Foundations of Probabilistic Programming. Cambridge University Press; 2020:221-258. doi:10.1017/9781108770750.008","ista":"Chatterjee K, Fu H, Novotný P. 2020.Termination Analysis of Probabilistic Programs with Martingales. In: Foundations of Probabilistic Programming. , 221–258.","apa":"Chatterjee, K., Fu, H., & Novotný, P. (2020). Termination Analysis of Probabilistic Programs with Martingales. In Foundations of Probabilistic Programming (pp. 221–258). Cambridge University Press. https://doi.org/10.1017/9781108770750.008","short":"K. Chatterjee, H. Fu, P. Novotný, in:, Foundations of Probabilistic Programming, Cambridge University Press, 2020, pp. 221–258.","mla":"Chatterjee, Krishnendu, et al. “Termination Analysis of Probabilistic Programs with Martingales.” Foundations of Probabilistic Programming, Cambridge University Press, 2020, pp. 221–58, doi:10.1017/9781108770750.008.","chicago":"Chatterjee, Krishnendu, Hongfei Fu, and Petr Novotný. “Termination Analysis of Probabilistic Programs with Martingales.” In Foundations of Probabilistic Programming, 221–58. Cambridge University Press, 2020. https://doi.org/10.1017/9781108770750.008."},"type":"book_chapter","corr_author":"1","oa_version":"Published Version","date_created":"2025-07-10T13:28:51Z","publication":"Foundations of Probabilistic Programming","has_accepted_license":"1","status":"public","abstract":[{"lang":"eng","text":"For non-probabilistic programs, a key question in static analysis is termination, which asks whether a given program terminates under a given initial condition. In the presence of probabilistic behaviour, there are two fundamental extensions of the termination question: (a) the almost-sure termination question, which asks whether the termination probability is 1; and (b) the bounded-time termination question, which asks whether the expected termination time is bounded. There are many active research directions to address these two questions; one important such direction is the use of martingale theory for termination analysis. In this chapter, we survey the main techniques of the martingale-based approach to the termination analysis of probabilistic programs."}],"project":[{"call_identifier":"FWF","_id":"25863FF4-B435-11E9-9278-68D0E5697425","name":"Game Theory","grant_number":"S11407"}],"OA_place":"publisher","ddc":["000"],"date_updated":"2025-09-23T12:10:25Z","page":"221-258","author":[{"last_name":"Chatterjee","orcid":"0000-0002-4561-241X","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Fu","first_name":"Hongfei","full_name":"Fu, Hongfei","id":"3AAD03D6-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Novotný, Petr","id":"3CC3B868-F248-11E8-B48F-1D18A9856A87","first_name":"Petr","last_name":"Novotný"}],"month":"11","year":"2020","file_date_updated":"2025-09-23T12:03:09Z","publication_status":"published"},{"publication_identifier":{"issn":["0002-7863"],"eissn":["1520-5126"]},"article_processing_charge":"No","day":"01","title":"Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","_id":"20766","date_published":"2020-06-01T00:00:00Z","publisher":"American Chemical Society","doi":"10.1021/jacs.0c03184","extern":"1","page":"10914-10920","pmid":1,"author":[{"full_name":"Bhawal, Benjamin N.","first_name":"Benjamin N.","last_name":"Bhawal"},{"first_name":"Julia","last_name":"Reisenbauer","full_name":"Reisenbauer, Julia","id":"51d862e9-36ee-11f0-86d3-8534c85a5496"},{"full_name":"Ehinger, Christian","first_name":"Christian","last_name":"Ehinger"},{"full_name":"Morandi, Bill","first_name":"Bill","last_name":"Morandi"}],"month":"06","volume":142,"issue":"25","publication_status":"published","year":"2020","language":[{"iso":"eng"}],"citation":{"short":"B.N. Bhawal, J. Reisenbauer, C. Ehinger, B. Morandi, Journal of the American Chemical Society 142 (2020) 10914–10920.","mla":"Bhawal, Benjamin N., et al. “Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control.” Journal of the American Chemical Society, vol. 142, no. 25, American Chemical Society, 2020, pp. 10914–20, doi:10.1021/jacs.0c03184.","ieee":"B. N. Bhawal, J. Reisenbauer, C. Ehinger, and B. Morandi, “Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control,” Journal of the American Chemical Society, vol. 142, no. 25. American Chemical Society, pp. 10914–10920, 2020.","ama":"Bhawal BN, Reisenbauer J, Ehinger C, Morandi B. Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. 2020;142(25):10914-10920. doi:10.1021/jacs.0c03184","ista":"Bhawal BN, Reisenbauer J, Ehinger C, Morandi B. 2020. Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. 142(25), 10914–10920.","apa":"Bhawal, B. N., Reisenbauer, J., Ehinger, C., & Morandi, B. (2020). Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control. Journal of the American Chemical Society. American Chemical Society. https://doi.org/10.1021/jacs.0c03184","chicago":"Bhawal, Benjamin N., Julia Reisenbauer, Christian Ehinger, and Bill Morandi. “Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control.” Journal of the American Chemical Society. American Chemical Society, 2020. https://doi.org/10.1021/jacs.0c03184."},"article_type":"original","external_id":{"pmid":["32478515"]},"status":"public","abstract":[{"text":"Reversible catalytic reactions operate under thermodynamic control, and thus, establishing a selective catalytic system poses a considerable challenge. Herein, we report a reversible transfer hydrocyanation protocol that exhibits high selectivity for the thermodynamically less favorable branched isomer. Selectivity is achieved by exploiting the lower barrier for C–CN oxidative addition and reductive elimination at benzylic positions in the absence of a cocatalytic Lewis acid. Through the design of a novel type of HCN donor, a practical, branched-selective, HCN-free transfer hydrocyanation was realized. The synthetically useful resolution of a mixture of branched and linear nitrile isomers was also demonstrated to underline the value of reversible and selective transfer reactions. In a broader context, this work demonstrates that high kinetic selectivity can be achieved in reversible transfer reactions, thus opening new horizons for their synthetic applications.","lang":"eng"}],"type":"journal_article","main_file_link":[{"url":"10.26434/chemrxiv.11931633.v1","open_access":"1"}],"date_created":"2025-12-09T14:25:37Z","publication":"Journal of the American Chemical Society","oa_version":"Preprint","scopus_import":"1","OA_type":"green","date_updated":"2025-12-16T12:10:08Z","intvolume":" 142","OA_place":"repository"},{"abstract":[{"text":"We prove that in the absence of topological changes, the notion of BV solutions to planar multiphase mean curvature flow does not allow for a mechanism for (unphysical) non-uniqueness. Our approach is based on the local structure of the energy landscape near a classical evolution by mean curvature. Mean curvature flow being the gradient flow of the surface energy functional, we develop a gradient-flow analogue of the notion of calibrations. Just like the existence of a calibration guarantees that one has reached a global minimum in the energy landscape, the existence of a \"gradient flow calibration\" ensures that the route of steepest descent in the energy landscape is unique and stable.","lang":"eng"}],"external_id":{"arxiv":["2003.05478"]},"status":"public","publication":"arXiv","oa_version":"Preprint","date_created":"2021-09-13T12:17:11Z","type":"preprint","main_file_link":[{"url":"https://arxiv.org/abs/2003.05478","open_access":"1"}],"citation":{"short":"J.L. Fischer, S. Hensel, T. Laux, T. Simon, ArXiv (n.d.).","mla":"Fischer, Julian L., et al. “The Local Structure of the Energy Landscape in Multiphase Mean Curvature Flow: Weak-Strong Uniqueness and Stability of Evolutions.” ArXiv, 2003.05478, doi:10.48550/arXiv.2003.05478.","ieee":"J. L. Fischer, S. Hensel, T. Laux, and T. Simon, “The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions,” arXiv. .","ista":"Fischer JL, Hensel S, Laux T, Simon T. The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions. arXiv, 2003.05478.","ama":"Fischer JL, Hensel S, Laux T, Simon T. The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions. arXiv. doi:10.48550/arXiv.2003.05478","apa":"Fischer, J. L., Hensel, S., Laux, T., & Simon, T. (n.d.). The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions. arXiv. https://doi.org/10.48550/arXiv.2003.05478","chicago":"Fischer, Julian L, Sebastian Hensel, Tim Laux, and Thilo Simon. “The Local Structure of the Energy Landscape in Multiphase Mean Curvature Flow: Weak-Strong Uniqueness and Stability of Evolutions.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2003.05478."},"ec_funded":1,"language":[{"iso":"eng"}],"article_number":"2003.05478","_id":"10012","date_published":"2020-03-11T00:00:00Z","date_updated":"2026-04-08T07:01:01Z","arxiv":1,"doi":"10.48550/arXiv.2003.05478","project":[{"call_identifier":"H2020","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"}],"acknowledgement":"Parts of the paper were written during the visit of the authors to the Hausdorff Research Institute for Mathematics (HIM), University of Bonn, in the framework of the trimester program “Evolution of Interfaces”. The support and the hospitality of HIM are gratefully acknowledged. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 665385.","author":[{"last_name":"Fischer","first_name":"Julian L","orcid":"0000-0002-0479-558X","id":"2C12A0B0-F248-11E8-B48F-1D18A9856A87","full_name":"Fischer, Julian L"},{"full_name":"Hensel, Sebastian","id":"4D23B7DA-F248-11E8-B48F-1D18A9856A87","last_name":"Hensel","orcid":"0000-0001-7252-8072","first_name":"Sebastian"},{"last_name":"Laux","first_name":"Tim","full_name":"Laux, Tim"},{"first_name":"Thilo","last_name":"Simon","full_name":"Simon, Thilo"}],"article_processing_charge":"No","oa":1,"publication_status":"draft","title":"The local structure of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions","year":"2020","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JuFi"}],"month":"03","day":"11","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"10007"}]}},{"citation":{"ama":"Forkert DL, Maas J, Portinale L. Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions. arXiv. doi:10.48550/arXiv.2008.10962","ista":"Forkert DL, Maas J, Portinale L. Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions. arXiv, 2008.10962.","ieee":"D. L. Forkert, J. Maas, and L. Portinale, “Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions,” arXiv. .","apa":"Forkert, D. L., Maas, J., & Portinale, L. (n.d.). Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions. arXiv. https://doi.org/10.48550/arXiv.2008.10962","short":"D.L. Forkert, J. Maas, L. Portinale, ArXiv (n.d.).","mla":"Forkert, Dominik L., et al. “Evolutionary Γ-Convergence of Entropic Gradient Flow Structures for Fokker-Planck Equations in Multiple Dimensions.” ArXiv, 2008.10962, doi:10.48550/arXiv.2008.10962.","chicago":"Forkert, Dominik L, Jan Maas, and Lorenzo Portinale. “Evolutionary Γ-Convergence of Entropic Gradient Flow Structures for Fokker-Planck Equations in Multiple Dimensions.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2008.10962."},"ec_funded":1,"language":[{"iso":"eng"}],"oa_version":"Preprint","date_created":"2021-09-17T10:57:27Z","publication":"arXiv","type":"preprint","main_file_link":[{"url":"https://arxiv.org/abs/2008.10962","open_access":"1"}],"corr_author":"1","abstract":[{"text":"We consider finite-volume approximations of Fokker-Planck equations on bounded convex domains in R^d and study the corresponding gradient flow structures. We reprove the convergence of the discrete to continuous Fokker-Planck equation via the method of Evolutionary Γ-convergence, i.e., we pass to the limit at the level of the gradient flow structures, generalising the one-dimensional result obtained by Disser and Liero. The proof is of variational nature and relies on a Mosco convergence result for functionals in the discrete-to-continuum limit that is of independent interest. Our results apply to arbitrary regular meshes, even though the associated discrete transport distances may fail to converge to the Wasserstein distance in this generality.","lang":"eng"}],"status":"public","external_id":{"arxiv":["2008.10962"]},"project":[{"grant_number":"716117","call_identifier":"H2020","_id":"256E75B8-B435-11E9-9278-68D0E5697425","name":"Optimal Transport and Stochastic Dynamics"},{"_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2","name":"Taming Complexity in Partial Differential Systems","grant_number":"F6504"}],"date_updated":"2026-04-08T07:00:03Z","arxiv":1,"author":[{"full_name":"Forkert, Dominik L","id":"35C79D68-F248-11E8-B48F-1D18A9856A87","first_name":"Dominik L","last_name":"Forkert"},{"last_name":"Maas","orcid":"0000-0002-0845-1338","first_name":"Jan","full_name":"Maas, Jan","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Portinale","first_name":"Lorenzo","id":"30AD2CBC-F248-11E8-B48F-1D18A9856A87","full_name":"Portinale, Lorenzo"}],"related_material":{"record":[{"relation":"later_version","status":"public","id":"11739"},{"relation":"dissertation_contains","id":"10030","status":"public"}]},"month":"08","year":"2020","publication_status":"draft","_id":"10022","date_published":"2020-08-25T00:00:00Z","article_number":"2008.10962","doi":"10.48550/arXiv.2008.10962","acknowledgement":"This work is supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 716117) and by the Austrian Science Fund (FWF), grants No F65 and W1245.","article_processing_charge":"No","day":"25","department":[{"_id":"JaMa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"title":"Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions"},{"publisher":"National Academy of Sciences","doi":"10.1073/pnas.2007694117","acknowledgement":"We thank T. C. T. Michaels for reading the manuscript. This work was supported by the Academy of Medical Science (J.K. and A.Š.), the Cambridge Center for Misfolding Diseases (T.P.J.K.), the Biotechnology and Biological Sciences Research Council (T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.), the European Research Council Grant PhysProt Agreement 337969, the Wellcome Trust (A.Š. and T.P.J.K.), the Royal Society (A.Š.), the Medical Research Council (J.K. and A.Š.), and the UK Materials and Molecular Modeling Hub for computational resources, which is partially funded by Engineering and Physical Sciences Research Council Grant EP/P020194/1.","extern":"1","quality_controlled":"1","_id":"10336","date_published":"2020-12-16T00:00:00Z","day":"16","title":"Physical mechanisms of amyloid nucleation on fluid membranes","oa":1,"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"article_processing_charge":"No","date_updated":"2021-11-25T15:35:58Z","intvolume":" 117","language":[{"iso":"eng"}],"citation":{"ama":"Krausser J, Knowles TPJ, Šarić A. Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. 2020;117(52):33090-33098. doi:10.1073/pnas.2007694117","ista":"Krausser J, Knowles TPJ, Šarić A. 2020. Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. 117(52), 33090–33098.","ieee":"J. Krausser, T. P. J. Knowles, and A. Šarić, “Physical mechanisms of amyloid nucleation on fluid membranes,” Proceedings of the National Academy of Sciences, vol. 117, no. 52. National Academy of Sciences, pp. 33090–33098, 2020.","apa":"Krausser, J., Knowles, T. P. J., & Šarić, A. (2020). Physical mechanisms of amyloid nucleation on fluid membranes. Proceedings of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.2007694117","short":"J. Krausser, T.P.J. Knowles, A. Šarić, Proceedings of the National Academy of Sciences 117 (2020) 33090–33098.","mla":"Krausser, Johannes, et al. “Physical Mechanisms of Amyloid Nucleation on Fluid Membranes.” Proceedings of the National Academy of Sciences, vol. 117, no. 52, National Academy of Sciences, 2020, pp. 33090–98, doi:10.1073/pnas.2007694117.","chicago":"Krausser, Johannes, Tuomas P. J. Knowles, and Anđela Šarić. “Physical Mechanisms of Amyloid Nucleation on Fluid Membranes.” Proceedings of the National Academy of Sciences. National Academy of Sciences, 2020. https://doi.org/10.1073/pnas.2007694117."},"article_type":"original","status":"public","external_id":{"pmid":["33328273"]},"abstract":[{"lang":"eng","text":"Biological membranes can dramatically accelerate the aggregation of normally soluble protein molecules into amyloid fibrils and alter the fibril morphologies, yet the molecular mechanisms through which this accelerated nucleation takes place are not yet understood. Here, we develop a coarse-grained model to systematically explore the effect that the structural properties of the lipid membrane and the nature of protein–membrane interactions have on the nucleation rates of amyloid fibrils. We identify two physically distinct nucleation pathways—protein-rich and lipid-rich—and quantify how the membrane fluidity and protein–membrane affinity control the relative importance of those molecular pathways. We find that the membrane’s susceptibility to reshaping and being incorporated into the fibrillar aggregates is a key determinant of its ability to promote protein aggregation. We then characterize the rates and the free-energy profile associated with this heterogeneous nucleation process, in which the surface itself participates in the aggregate structure. Finally, we compare quantitatively our data to experiments on membrane-catalyzed amyloid aggregation of α-synuclein, a protein implicated in Parkinson’s disease that predominately nucleates on membranes. More generally, our results provide a framework for understanding macromolecular aggregation on lipid membranes in a broad biological and biotechnological context."}],"main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2019.12.22.886267v2"}],"type":"journal_article","date_created":"2021-11-25T15:07:09Z","publication":"Proceedings of the National Academy of Sciences","scopus_import":"1","oa_version":"Published Version","month":"12","volume":117,"issue":"52","publication_status":"published","year":"2020","page":"33090-33098","pmid":1,"author":[{"full_name":"Krausser, Johannes","first_name":"Johannes","last_name":"Krausser"},{"last_name":"Knowles","first_name":"Tuomas P. J.","full_name":"Knowles, Tuomas P. J."},{"id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela","first_name":"Anđela","orcid":"0000-0002-7854-2139","last_name":"Šarić"}]},{"publisher":"Royal Society of Chemistry","doi":"10.1039/d0sm00712a","acknowledgement":"We thank Jessica McQuade for her input at the start of the project. We acknowledge support from the ERASMUS Placement Programme (V. E. D.), the UCL Institute for the Physics of Living Systems (V. E. D. and A. Š.), the UCL Global Engagement Fund (L. M. C. J.), and the Royal Society (A. Š.).","extern":"1","_id":"10341","date_published":"2020-10-06T00:00:00Z","quality_controlled":"1","day":"06","keyword":["condensed matter physics","general chemistry"],"title":"Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes","oa":1,"user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","publication_identifier":{"issn":["1744-683X","1744-6848"]},"article_processing_charge":"No","OA_type":"hybrid","date_updated":"2024-10-16T12:53:17Z","intvolume":" 16","OA_place":"publisher","language":[{"iso":"eng"}],"article_type":"original","citation":{"ama":"Debets VE, Janssen LMC, Šarić A. Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. 2020;16(47):10628-10639. doi:10.1039/d0sm00712a","ista":"Debets VE, Janssen LMC, Šarić A. 2020. Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. 16(47), 10628–10639.","ieee":"V. E. Debets, L. M. C. Janssen, and A. Šarić, “Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes,” Soft Matter, vol. 16, no. 47. Royal Society of Chemistry, pp. 10628–10639, 2020.","apa":"Debets, V. E., Janssen, L. M. C., & Šarić, A. (2020). Characterising the diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft Matter. Royal Society of Chemistry. https://doi.org/10.1039/d0sm00712a","short":"V.E. Debets, L.M.C. Janssen, A. Šarić, Soft Matter 16 (2020) 10628–10639.","mla":"Debets, V. E., et al. “Characterising the Diffusion of Biological Nanoparticles on Fluid and Cross-Linked Membranes.” Soft Matter, vol. 16, no. 47, Royal Society of Chemistry, 2020, pp. 10628–39, doi:10.1039/d0sm00712a.","chicago":"Debets, V. E., L. M. C. Janssen, and Anđela Šarić. “Characterising the Diffusion of Biological Nanoparticles on Fluid and Cross-Linked Membranes.” Soft Matter. Royal Society of Chemistry, 2020. https://doi.org/10.1039/d0sm00712a."},"external_id":{"pmid":["33084724"]},"status":"public","abstract":[{"text":"Tracing the motion of macromolecules, viruses, and nanoparticles adsorbed onto cell membranes is currently the most direct way of probing the complex dynamic interactions behind vital biological processes, including cell signalling, trafficking, and viral infection. The resulting trajectories are usually consistent with some type of anomalous diffusion, but the molecular origins behind the observed anomalous behaviour are usually not obvious. Here we use coarse-grained molecular dynamics simulations to help identify the physical mechanisms that can give rise to experimentally observed trajectories of nanoscopic objects moving on biological membranes. We find that diffusion on membranes of high fluidities typically results in normal diffusion of the adsorbed nanoparticle, irrespective of the concentration of receptors, receptor clustering, or multivalent interactions between the particle and membrane receptors. Gel-like membranes on the other hand result in anomalous diffusion of the particle, which becomes more pronounced at higher receptor concentrations. This anomalous diffusion is characterised by local particle trapping in the regions of high receptor concentrations and fast hopping between such regions. The normal diffusion is recovered in the limit where the gel membrane is saturated with receptors. We conclude that hindered receptor diffusivity can be a common reason behind the observed anomalous diffusion of viruses, vesicles, and nanoparticles adsorbed on cell and model membranes. Our results enable direct comparison with experiments and offer a new route for interpreting motility experiments on cell membranes.","lang":"eng"}],"type":"journal_article","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2020.05.01.071761v1"}],"date_created":"2021-11-26T06:29:41Z","scopus_import":"1","publication":"Soft Matter","oa_version":"Published Version","month":"10","volume":16,"issue":"47","publication_status":"published","year":"2020","page":"10628-10639","pmid":1,"author":[{"full_name":"Debets, V. E.","last_name":"Debets","first_name":"V. E."},{"last_name":"Janssen","first_name":"L. M. C.","full_name":"Janssen, L. M. C."},{"orcid":"0000-0002-7854-2139","first_name":"Anđela","last_name":"Šarić","full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b"}]},{"_id":"10342","date_published":"2020-11-27T00:00:00Z","quality_controlled":"1","article_number":"eabc4397 ","extern":"1","acknowledgement":"Funding: G.B. thanks the ERC for the starting grant (MEViC 278793) and consolidator award (CheSSTaG 769798), EPSRC/BTG Healthcare Partnership (EP/I001697/1), EPSRC Established Career Fellowship (EP/N026322/1), EPSRC/SomaNautix Healthcare Partnership EP/R024723/1, and Children with Cancer UK for the research project (16-227). X.T. and G.B. thank that Anhui 100 Talent program for facilitating data sharing and research visits. A.D.-C. and L.R. acknowledge the Royal Society for a Newton fellowship and the Marie Skłodowska-Curie Actions for a European Fellowship. Author contributions: X.T. prepared and characterized POs, performed all the fast imaging in both conventional and STED microscopy, set up the initial BBB model, encapsulated the PtA2 in POs, and supervised the PtA2-PO animal work. D.M.L. prepared and characterized POs; performed all the permeability studies, PLA assays, WB and associated data analysis, and part of the colocalization assays; and performed experiments with the shRNA for knockdown of syndapin-2. E.S. prepared and characterized POs and performed part of colocalization assays and Cy7-labeled PO animal experiments. S.N. prepared and characterized POs and performed part of the colocalization and inhibition assays. G.F. designed, performed, and analyzed the agent-based simulations of transcytosis. J.F. designed the image-based algorithm to analyze the PLA data. D.M. prepared and characterized POs and helped with Cy7-labeled PO animal experiments. A.A. performed TEM imaging of the POs. A.P. and A.D.-C. synthesized the dye- and peptide-functionalized and pristine copolymers. M.V., L.H.-K., and A.Š. designed, performed, and analyzed the MD simulations. Z.Z. supervised and supported STED imaging. P.X., B.F., and Y.T. synthesized and characterized the PtA2 compound. L.L. performed some of the animal work. L.R. supported and helped with the BBB characterization. G.B. analyzed all fast imaging and supervised and coordinated the overall work. X.T., D.M.L., E.S., and G.B. wrote the manuscript. Competing interests: The authors declare that part of the work is associated with the UCL spin-out company SomaNautix Ltd. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the authors.","file":[{"creator":"cchlebak","relation":"main_file","access_level":"open_access","content_type":"application/pdf","date_created":"2021-11-26T06:50:09Z","file_size":10381298,"checksum":"3ba2eca975930cdb0b1ce1ae876885a7","success":1,"file_id":"10343","file_name":"2020_SciAdv_Tian.pdf","date_updated":"2021-11-26T06:50:09Z"}],"doi":"10.1126/sciadv.abc4397","publisher":"American Association for the Advancement of Science","article_processing_charge":"No","publication_identifier":{"issn":["2375-2548"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","oa":1,"title":"On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias","day":"27","keyword":["multidisciplinary"],"scopus_import":"1","oa_version":"Published Version","publication":"Science Advances","date_created":"2021-11-26T06:40:28Z","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2020.04.04.025866v1"}],"type":"journal_article","abstract":[{"lang":"eng","text":"The blood-brain barrier is made of polarized brain endothelial cells (BECs) phenotypically conditioned by the central nervous system (CNS). Although transport across BECs is of paramount importance for nutrient uptake as well as ridding the brain of waste products, the intracellular sorting mechanisms that regulate successful receptor-mediated transcytosis in BECs remain to be elucidated. Here, we used a synthetic multivalent system with tunable avidity to the low-density lipoprotein receptor–related protein 1 (LRP1) to investigate the mechanisms of transport across BECs. We used a combination of conventional and super-resolution microscopy, both in vivo and in vitro, accompanied with biophysical modeling of transport kinetics and membrane-bound interactions to elucidate the role of membrane-sculpting protein syndapin-2 on fast transport via tubule formation. We show that high-avidity cargo biases the LRP1 toward internalization associated with fast degradation, while mid-avidity augments the formation of syndapin-2 tubular carriers promoting a fast shuttling across."}],"has_accepted_license":"1","external_id":{"pmid":["33246953"]},"status":"public","citation":{"short":"X. Tian, D.M. Leite, E. Scarpa, S. Nyberg, G. Fullstone, J. Forth, D. Matias, A. Apriceno, A. Poma, A. Duro-Castano, M. Vuyyuru, L. Harker-Kirschneck, A. Šarić, Z. Zhang, P. Xiang, B. Fang, Y. Tian, L. Luo, L. Rizzello, G. Battaglia, Science Advances 6 (2020).","mla":"Tian, Xiaohe, et al. “On the Shuttling across the Blood-Brain Barrier via Tubule Formation: Mechanism and Cargo Avidity Bias.” Science Advances, vol. 6, no. 48, eabc4397, American Association for the Advancement of Science, 2020, doi:10.1126/sciadv.abc4397.","ista":"Tian X, Leite DM, Scarpa E, Nyberg S, Fullstone G, Forth J, Matias D, Apriceno A, Poma A, Duro-Castano A, Vuyyuru M, Harker-Kirschneck L, Šarić A, Zhang Z, Xiang P, Fang B, Tian Y, Luo L, Rizzello L, Battaglia G. 2020. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. 6(48), eabc4397.","ieee":"X. Tian et al., “On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias,” Science Advances, vol. 6, no. 48. American Association for the Advancement of Science, 2020.","ama":"Tian X, Leite DM, Scarpa E, et al. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. 2020;6(48). doi:10.1126/sciadv.abc4397","apa":"Tian, X., Leite, D. M., Scarpa, E., Nyberg, S., Fullstone, G., Forth, J., … Battaglia, G. (2020). On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.abc4397","chicago":"Tian, Xiaohe, Diana M. Leite, Edoardo Scarpa, Sophie Nyberg, Gavin Fullstone, Joe Forth, Diana Matias, et al. “On the Shuttling across the Blood-Brain Barrier via Tubule Formation: Mechanism and Cargo Avidity Bias.” Science Advances. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/sciadv.abc4397."},"article_type":"original","DOAJ_listed":"1","language":[{"iso":"eng"}],"intvolume":" 6","OA_place":"publisher","date_updated":"2024-10-16T12:56:52Z","ddc":["611"],"OA_type":"gold","author":[{"last_name":"Tian","first_name":"Xiaohe","full_name":"Tian, Xiaohe"},{"last_name":"Leite","first_name":"Diana M.","full_name":"Leite, Diana M."},{"first_name":"Edoardo","last_name":"Scarpa","full_name":"Scarpa, Edoardo"},{"last_name":"Nyberg","first_name":"Sophie","full_name":"Nyberg, Sophie"},{"first_name":"Gavin","last_name":"Fullstone","full_name":"Fullstone, Gavin"},{"first_name":"Joe","last_name":"Forth","full_name":"Forth, Joe"},{"full_name":"Matias, Diana","last_name":"Matias","first_name":"Diana"},{"first_name":"Azzurra","last_name":"Apriceno","full_name":"Apriceno, Azzurra"},{"full_name":"Poma, Alessandro","last_name":"Poma","first_name":"Alessandro"},{"full_name":"Duro-Castano, Aroa","last_name":"Duro-Castano","first_name":"Aroa"},{"full_name":"Vuyyuru, Manish","first_name":"Manish","last_name":"Vuyyuru"},{"last_name":"Harker-Kirschneck","first_name":"Lena","full_name":"Harker-Kirschneck, Lena"},{"orcid":"0000-0002-7854-2139","first_name":"Anđela","last_name":"Šarić","full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b"},{"full_name":"Zhang, Zhongping","last_name":"Zhang","first_name":"Zhongping"},{"full_name":"Xiang, Pan","first_name":"Pan","last_name":"Xiang"},{"full_name":"Fang, Bin","last_name":"Fang","first_name":"Bin"},{"full_name":"Tian, Yupeng","first_name":"Yupeng","last_name":"Tian"},{"full_name":"Luo, Lei","first_name":"Lei","last_name":"Luo"},{"last_name":"Rizzello","first_name":"Loris","full_name":"Rizzello, Loris"},{"last_name":"Battaglia","first_name":"Giuseppe","full_name":"Battaglia, Giuseppe"}],"pmid":1,"year":"2020","file_date_updated":"2021-11-26T06:50:09Z","publication_status":"published","issue":"48","volume":6,"month":"11"},{"citation":{"chicago":"Forster, Joel C., Johannes Krausser, Manish R. Vuyyuru, Buzz Baum, and Anđela Šarić. “Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures.” Physical Review Letters. American Physical Society, 2020. https://doi.org/10.1103/physrevlett.125.228101.","apa":"Forster, J. C., Krausser, J., Vuyyuru, M. R., Baum, B., & Šarić, A. (2020). Exploring the design rules for efficient membrane-reshaping nanostructures. Physical Review Letters. American Physical Society. https://doi.org/10.1103/physrevlett.125.228101","ieee":"J. C. Forster, J. Krausser, M. R. Vuyyuru, B. Baum, and A. Šarić, “Exploring the design rules for efficient membrane-reshaping nanostructures,” Physical Review Letters, vol. 125, no. 22. American Physical Society, 2020.","ama":"Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. Exploring the design rules for efficient membrane-reshaping nanostructures. Physical Review Letters. 2020;125(22). doi:10.1103/physrevlett.125.228101","ista":"Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. 2020. Exploring the design rules for efficient membrane-reshaping nanostructures. Physical Review Letters. 125(22), 228101.","mla":"Forster, Joel C., et al. “Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures.” Physical Review Letters, vol. 125, no. 22, 228101, American Physical Society, 2020, doi:10.1103/physrevlett.125.228101.","short":"J.C. Forster, J. Krausser, M.R. Vuyyuru, B. Baum, A. Šarić, Physical Review Letters 125 (2020)."},"article_type":"original","language":[{"iso":"eng"}],"abstract":[{"text":"In this study, we investigate the role of the surface patterning of nanostructures for cell membrane reshaping. To accomplish this, we combine an evolutionary algorithm with coarse-grained molecular dynamics simulations and explore the solution space of ligand patterns on a nanoparticle that promote efficient and reliable cell uptake. Surprisingly, we find that in the regime of low ligand number the best-performing structures are characterized by ligands arranged into long one-dimensional chains that pattern the surface of the particle. We show that these chains of ligands provide particles with high rotational freedom and they lower the free energy barrier for membrane crossing. Our approach reveals a set of nonintuitive design rules that can be used to inform artificial nanoparticle construction and the search for inhibitors of viral entry.","lang":"eng"}],"status":"public","external_id":{"pmid":["33315453"]},"has_accepted_license":"1","scopus_import":"1","publication":"Physical Review Letters","oa_version":"Published Version","date_created":"2021-11-26T07:10:43Z","type":"journal_article","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2020.02.27.968149v1"}],"OA_type":"hybrid","date_updated":"2024-10-16T12:59:57Z","ddc":["530"],"intvolume":" 125","OA_place":"publisher","pmid":1,"author":[{"first_name":"Joel C.","last_name":"Forster","full_name":"Forster, Joel C."},{"full_name":"Krausser, Johannes","first_name":"Johannes","last_name":"Krausser"},{"first_name":"Manish R.","last_name":"Vuyyuru","full_name":"Vuyyuru, Manish R."},{"last_name":"Baum","first_name":"Buzz","full_name":"Baum, Buzz"},{"first_name":"Anđela","orcid":"0000-0002-7854-2139","last_name":"Šarić","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela"}],"month":"11","issue":"22","volume":125,"publication_status":"published","file_date_updated":"2021-11-26T07:16:49Z","year":"2020","article_number":"228101","_id":"10344","date_published":"2020-11-23T00:00:00Z","quality_controlled":"1","publisher":"American Physical Society","acknowledgement":"We acknowledge support from EPSRC (J. C. F.), MRC (B. B. and A. Š.), the ERC StG 802960 “NEPA” (J. K. and A. Š.), the Royal Society (A. Š.), and the United Kingdom Materials and Molecular Modelling Hub for computational resources, which is partially funded by EPSRC (EP/P020194/1).","doi":"10.1103/physrevlett.125.228101","file":[{"relation":"main_file","creator":"cchlebak","access_level":"open_access","content_type":"application/pdf","date_created":"2021-11-26T07:16:49Z","file_size":844353,"checksum":"fbf2e1415e332d6add90222d60401a1d","success":1,"date_updated":"2021-11-26T07:16:49Z","file_name":"2020_PhysRevLett_Forster.pdf","file_id":"10345"}],"extern":"1","publication_identifier":{"eissn":["1079-7114"],"issn":["0031-9007"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"No","day":"23","oa":1,"title":"Exploring the design rules for efficient membrane-reshaping nanostructures","user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0"},{"oa":1,"title":"Modeling fibrillogenesis of collagen-mimetic molecules","user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","keyword":["biophysics"],"day":"23","publication_identifier":{"issn":["0006-3495"]},"article_processing_charge":"No","extern":"1","publisher":"Cell Press","doi":"10.1016/j.bpj.2020.09.013","acknowledgement":"We thank Melinda Duer, Patrick Mesquida, Lucy Colwell, Lucie Liu, Daan Frenkel, and Ivan Palaia for helpful discussions. We acknowledge support from the Engineering and Physical Sciences Research Council (A.E.H., L.K.D., and A.Š.), Biotechnology and Biological Sciences Research Council LIDo programme (N.G.G. and C.A.B.), the Royal Society (A.Š.), and the UK Materials and Molecular Modelling Hub for computational resources, which is partially funded by EPSRC ( EP/P020194/1).","_id":"10346","quality_controlled":"1","date_published":"2020-09-23T00:00:00Z","publication_status":"published","year":"2020","month":"09","issue":"9","volume":119,"author":[{"first_name":"Anne E.","last_name":"Hafner","full_name":"Hafner, Anne E."},{"full_name":"Gyori, Noemi G.","last_name":"Gyori","first_name":"Noemi G."},{"first_name":"Ciaran A.","last_name":"Bench","full_name":"Bench, Ciaran A."},{"first_name":"Luke K.","last_name":"Davis","full_name":"Davis, Luke K."},{"full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","last_name":"Šarić","orcid":"0000-0002-7854-2139","first_name":"Anđela"}],"page":"1791-1799","pmid":1,"date_updated":"2024-10-16T13:05:34Z","intvolume":" 119","OA_place":"publisher","OA_type":"hybrid","abstract":[{"text":"One of the most robust examples of self-assembly in living organisms is the formation of collagen architectures. Collagen type I molecules are a crucial component of the extracellular matrix, where they self-assemble into fibrils of well-defined axial striped patterns. This striped fibrillar pattern is preserved across the animal kingdom and is important for the determination of cell phenotype, cell adhesion, and tissue regulation and signaling. The understanding of the physical processes that determine such a robust morphology of self-assembled collagen fibrils is currently almost completely missing. Here, we develop a minimal coarse-grained computational model to identify the physical principles of the assembly of collagen-mimetic molecules. We find that screened electrostatic interactions can drive the formation of collagen-like filaments of well-defined striped morphologies. The fibril axial pattern is determined solely by the distribution of charges on the molecule and is robust to the changes in protein concentration, monomer rigidity, and environmental conditions. We show that the striped fibrillar pattern cannot be easily predicted from the interactions between two monomers but is an emergent result of multibody interactions. Our results can help address collagen remodeling in diseases and aging and guide the design of collagen scaffolds for biotechnological applications.","lang":"eng"}],"external_id":{"pmid":["33049216"]},"status":"public","publication":"Biophysical Journal","date_created":"2021-11-26T07:27:24Z","oa_version":"Published Version","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2020.06.08.140061v1"}],"type":"journal_article","citation":{"chicago":"Hafner, Anne E., Noemi G. Gyori, Ciaran A. Bench, Luke K. Davis, and Anđela Šarić. “Modeling Fibrillogenesis of Collagen-Mimetic Molecules.” Biophysical Journal. Cell Press, 2020. https://doi.org/10.1016/j.bpj.2020.09.013.","short":"A.E. Hafner, N.G. Gyori, C.A. Bench, L.K. Davis, A. Šarić, Biophysical Journal 119 (2020) 1791–1799.","mla":"Hafner, Anne E., et al. “Modeling Fibrillogenesis of Collagen-Mimetic Molecules.” Biophysical Journal, vol. 119, no. 9, Cell Press, 2020, pp. 1791–99, doi:10.1016/j.bpj.2020.09.013.","ista":"Hafner AE, Gyori NG, Bench CA, Davis LK, Šarić A. 2020. Modeling fibrillogenesis of collagen-mimetic molecules. Biophysical Journal. 119(9), 1791–1799.","ieee":"A. E. Hafner, N. G. Gyori, C. A. Bench, L. K. Davis, and A. Šarić, “Modeling fibrillogenesis of collagen-mimetic molecules,” Biophysical Journal, vol. 119, no. 9. Cell Press, pp. 1791–1799, 2020.","ama":"Hafner AE, Gyori NG, Bench CA, Davis LK, Šarić A. Modeling fibrillogenesis of collagen-mimetic molecules. Biophysical Journal. 2020;119(9):1791-1799. doi:10.1016/j.bpj.2020.09.013","apa":"Hafner, A. E., Gyori, N. G., Bench, C. A., Davis, L. K., & Šarić, A. (2020). Modeling fibrillogenesis of collagen-mimetic molecules. Biophysical Journal. Cell Press. https://doi.org/10.1016/j.bpj.2020.09.013"},"article_type":"original","language":[{"iso":"eng"}]},{"page":"24251-24257","pmid":1,"author":[{"full_name":"Michaels, Thomas C. T.","last_name":"Michaels","first_name":"Thomas C. T."},{"last_name":"Šarić","orcid":"0000-0002-7854-2139","first_name":"Anđela","full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b"},{"full_name":"Meisl, Georg","first_name":"Georg","last_name":"Meisl"},{"full_name":"Heller, Gabriella T.","last_name":"Heller","first_name":"Gabriella T."},{"last_name":"Curk","first_name":"Samo","full_name":"Curk, Samo"},{"first_name":"Paolo","last_name":"Arosio","full_name":"Arosio, Paolo"},{"full_name":"Linse, Sara","last_name":"Linse","first_name":"Sara"},{"last_name":"Dobson","first_name":"Christopher M.","full_name":"Dobson, Christopher M."},{"full_name":"Vendruscolo, Michele","last_name":"Vendruscolo","first_name":"Michele"},{"first_name":"Tuomas P. J.","last_name":"Knowles","full_name":"Knowles, Tuomas P. J."}],"month":"09","issue":"39","volume":117,"publication_status":"published","year":"2020","article_type":"original","citation":{"apa":"Michaels, T. C. T., Šarić, A., Meisl, G., Heller, G. T., Curk, S., Arosio, P., … Knowles, T. P. J. (2020). Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.2006684117","ama":"Michaels TCT, Šarić A, Meisl G, et al. Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences. 2020;117(39):24251-24257. doi:10.1073/pnas.2006684117","ieee":"T. C. T. Michaels et al., “Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors,” Proceedings of the National Academy of Sciences, vol. 117, no. 39. National Academy of Sciences, pp. 24251–24257, 2020.","ista":"Michaels TCT, Šarić A, Meisl G, Heller GT, Curk S, Arosio P, Linse S, Dobson CM, Vendruscolo M, Knowles TPJ. 2020. Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences. 117(39), 24251–24257.","mla":"Michaels, Thomas C. T., et al. “Thermodynamic and Kinetic Design Principles for Amyloid-Aggregation Inhibitors.” Proceedings of the National Academy of Sciences, vol. 117, no. 39, National Academy of Sciences, 2020, pp. 24251–57, doi:10.1073/pnas.2006684117.","short":"T.C.T. Michaels, A. Šarić, G. Meisl, G.T. Heller, S. Curk, P. Arosio, S. Linse, C.M. Dobson, M. Vendruscolo, T.P.J. Knowles, Proceedings of the National Academy of Sciences 117 (2020) 24251–24257.","chicago":"Michaels, Thomas C. T., Anđela Šarić, Georg Meisl, Gabriella T. Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher M. Dobson, Michele Vendruscolo, and Tuomas P. J. Knowles. “Thermodynamic and Kinetic Design Principles for Amyloid-Aggregation Inhibitors.” Proceedings of the National Academy of Sciences. National Academy of Sciences, 2020. https://doi.org/10.1073/pnas.2006684117."},"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Understanding the mechanism of action of compounds capable of inhibiting amyloid-fibril formation is critical to the development of potential therapeutics against protein-misfolding diseases. A fundamental challenge for progress is the range of possible target species and the disparate timescales involved, since the aggregating proteins are simultaneously the reactants, products, intermediates, and catalysts of the reaction. It is a complex problem, therefore, to choose the states of the aggregating proteins that should be bound by the compounds to achieve the most potent inhibition. We present here a comprehensive kinetic theory of amyloid-aggregation inhibition that reveals the fundamental thermodynamic and kinetic signatures characterizing effective inhibitors by identifying quantitative relationships between the aggregation and binding rate constants. These results provide general physical laws to guide the design and optimization of inhibitors of amyloid-fibril formation, revealing in particular the important role of on-rates in the binding of the inhibitors."}],"status":"public","external_id":{"pmid":["32929030"]},"date_created":"2021-11-26T07:48:27Z","scopus_import":"1","oa_version":"Published Version","publication":"Proceedings of the National Academy of Sciences","type":"journal_article","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2020.02.22.960716","open_access":"1"}],"date_updated":"2021-11-26T08:59:06Z","intvolume":" 117","publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"article_processing_charge":"No","day":"14","keyword":["multidisciplinary"],"oa":1,"title":"Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_published":"2020-09-14T00:00:00Z","_id":"10347","quality_controlled":"1","publisher":"National Academy of Sciences","acknowledgement":"We acknowledge support from Peterhouse, Cambridge (T.C.T.M.); the Swiss National Science Foundation (T.C.T.M.); the Royal Society (A.S. and S.C.); the Academy of Medical Sciences (A.S.); Sidney Sussex College, Cambridge (G.M.); Newnham College, Cambridge (G.T.H.); the Wellcome Trust (T.P.J.K.); the Cambridge Center for Misfolding Diseases (T.P.J.K. and M.V.); the Biotechnology and Biological Sciences Research Council (T.P.J.K.); the Frances and Augustus Newman Foundation (T.P.J.K.); and the Synapsis Foundation for Alzheimer’s disease (P.A.). The research leading to these results has received funding from the European Research Council (ERC) under the European Union’s Seventh Framework Program (FP7/2007-2013) through the ERC Grant PhysProt (Agreement 337969).","doi":"10.1073/pnas.2006684117","extern":"1"},{"_id":"10348","quality_controlled":"1","date_published":"2020-08-18T00:00:00Z","publisher":"Elsevier","doi":"10.1016/j.cell.2020.07.021","acknowledgement":"The authors thank Nicolas Chiaruttini, Jean Gruenberg, and Lena Harker-Kirschneck for careful correction of this manuscript and helpful discussions. The authors want to thank the NCCR Chemical Biology for constant support during this project. A.R. acknowledges funding from the Swiss National Fund for Research (31003A_130520, 31003A_149975, and 31003A_173087) and the European Research Council Consolidator (311536). A.Š. acknowledges the European Research Council (802960). B.B. thanks the BBSRC (BB/K009001/1) and Wellcome Trust (203276/Z/16/Z) for support. J.M.v.F. acknowledges funding through an EMBO Long-Term Fellowship (ALTF 1065-2015), the European Commission FP7 (Marie Curie Actions, LTFCOFUND2013, and GA-2013-609409), and a Transitional Postdoc fellowship (2015/345) from the Swiss SystemsX.ch initiative, evaluated by the Swiss National Science Foundation and Swiss National Science Foundation Research (SNSF SINERGIA 160728/1 [leader, Sophie Martin]).","extern":"1","publication_identifier":{"issn":["0092-8674"]},"article_processing_charge":"No","keyword":["general biochemistry","genetics and molecular biology"],"day":"18","oa":1,"title":"An ESCRT-III polymerization sequence drives membrane deformation and fission","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_type":"original","citation":{"mla":"Pfitzner, Anna-Katharina, et al. “An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission.” Cell, vol. 182, no. 5, Elsevier, 2020, p. 1140–1155.e18, doi:10.1016/j.cell.2020.07.021.","short":"A.-K. Pfitzner, V. Mercier, X. Jiang, J. Moser von Filseck, B. Baum, A. Šarić, A. Roux, Cell 182 (2020) 1140–1155.e18.","apa":"Pfitzner, A.-K., Mercier, V., Jiang, X., Moser von Filseck, J., Baum, B., Šarić, A., & Roux, A. (2020). An ESCRT-III polymerization sequence drives membrane deformation and fission. Cell. Elsevier. https://doi.org/10.1016/j.cell.2020.07.021","ista":"Pfitzner A-K, Mercier V, Jiang X, Moser von Filseck J, Baum B, Šarić A, Roux A. 2020. An ESCRT-III polymerization sequence drives membrane deformation and fission. Cell. 182(5), 1140–1155.e18.","ieee":"A.-K. Pfitzner et al., “An ESCRT-III polymerization sequence drives membrane deformation and fission,” Cell, vol. 182, no. 5. Elsevier, p. 1140–1155.e18, 2020.","ama":"Pfitzner A-K, Mercier V, Jiang X, et al. An ESCRT-III polymerization sequence drives membrane deformation and fission. Cell. 2020;182(5):1140-1155.e18. doi:10.1016/j.cell.2020.07.021","chicago":"Pfitzner, Anna-Katharina, Vincent Mercier, Xiuyun Jiang, Joachim Moser von Filseck, Buzz Baum, Anđela Šarić, and Aurélien Roux. “An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission.” Cell. Elsevier, 2020. https://doi.org/10.1016/j.cell.2020.07.021."},"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"The endosomal sorting complex required for transport-III (ESCRT-III) catalyzes membrane fission from within membrane necks, a process that is essential for many cellular functions, from cell division to lysosome degradation and autophagy. How it breaks membranes, though, remains unknown. Here, we characterize a sequential polymerization of ESCRT-III subunits that, driven by a recruitment cascade and by continuous subunit-turnover powered by the ATPase Vps4, induces membrane deformation and fission. During this process, the exchange of Vps24 for Did2 induces a tilt in the polymer-membrane interface, which triggers transition from flat spiral polymers to helical filament to drive the formation of membrane protrusions, and ends with the formation of a highly constricted Did2-Ist1 co-polymer that we show is competent to promote fission when bound on the inside of membrane necks. Overall, our results suggest a mechanism of stepwise changes in ESCRT-III filament structure and mechanical properties via exchange of the filament subunits to catalyze ESCRT-III activity."}],"external_id":{"pmid":["32814015"]},"status":"public","date_created":"2021-11-26T08:02:27Z","publication":"Cell","oa_version":"Published Version","scopus_import":"1","type":"journal_article","main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/S0092867420309296"}],"date_updated":"2021-11-26T08:58:37Z","intvolume":" 182","page":"1140-1155.e18","pmid":1,"author":[{"full_name":"Pfitzner, Anna-Katharina","last_name":"Pfitzner","first_name":"Anna-Katharina"},{"last_name":"Mercier","first_name":"Vincent","full_name":"Mercier, Vincent"},{"full_name":"Jiang, Xiuyun","first_name":"Xiuyun","last_name":"Jiang"},{"first_name":"Joachim","last_name":"Moser von Filseck","full_name":"Moser von Filseck, Joachim"},{"full_name":"Baum, Buzz","first_name":"Buzz","last_name":"Baum"},{"id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela","last_name":"Šarić","first_name":"Anđela","orcid":"0000-0002-7854-2139"},{"first_name":"Aurélien","last_name":"Roux","full_name":"Roux, Aurélien"}],"month":"08","issue":"5","volume":182,"publication_status":"published","year":"2020"},{"extern":"1","publisher":"American Association for the Advancement of Science","acknowledgement":"We thank the MRC LMCB at UCL for their support; the flow cytometry STP at the Francis Crick Institute for assistance, with special thanks to S. Purewal and D. Davis; C. Bertoli for mentorship\r\nand advice; J. M. Garcia-Arcos for help early on in this project; the entire Baum lab for their input throughout the project; the Albers lab for advice and reagents, with special thanks to M. Van Wolferen and S. Albers; the members of the Wellcome consortium for archaeal cytoskeleton studies for advice and comments; and J. Löwe, S. Oliferenko, M. Balasubramanian, and D. Gerlich for discussions and advice on the manuscript. N.P.R. and S.B. would like to thank N. Rzechorzek, A. Simon, and S. Anjum for discussion and advice.","doi":"10.1126/science.aaz2532","_id":"10349","date_published":"2020-08-07T00:00:00Z","quality_controlled":"1","oa":1,"title":"The proteasome controls ESCRT-III–mediated cell division in an archaeon","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","keyword":["multidisciplinary"],"day":"07","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"article_processing_charge":"No","date_updated":"2021-11-26T08:58:33Z","intvolume":" 369","abstract":[{"text":"Sulfolobus acidocaldarius is the closest experimentally tractable archaeal relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases of DNA replication and division. Here, in exploring the mechanism of cell division in S. acidocaldarius, we identify a role for the archaeal proteasome in regulating the transition from the end of one cell cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome and show that its degradation triggers division by allowing constriction of the CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism for ESCRT-III–mediated membrane remodeling and point to a conserved role for the proteasome in eukaryotic and archaeal cell cycle control.","lang":"eng"}],"status":"public","external_id":{"pmid":["32764038"]},"oa_version":"Preprint","publication":"Science","scopus_import":"1","date_created":"2021-11-26T08:21:34Z","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/774273v1","open_access":"1"}],"type":"journal_article","citation":{"short":"G. Tarrason Risa, F. Hurtig, S. Bray, A.E. Hafner, L. Harker-Kirschneck, P. Faull, C. Davis, D. Papatziamou, D.R. Mutavchiev, C. Fan, L. Meneguello, A. Arashiro Pulschen, G. Dey, S. Culley, M. Kilkenny, D.P. Souza, L. Pellegrini, R.A.M. de Bruin, R. Henriques, A.P. Snijders, A. Šarić, A.-C. Lindås, N.P. Robinson, B. Baum, Science 369 (2020).","mla":"Tarrason Risa, Gabriel, et al. “The Proteasome Controls ESCRT-III–Mediated Cell Division in an Archaeon.” Science, vol. 369, no. 6504, American Association for the Advancement of Science, 2020, doi:10.1126/science.aaz2532.","ieee":"G. Tarrason Risa et al., “The proteasome controls ESCRT-III–mediated cell division in an archaeon,” Science, vol. 369, no. 6504. American Association for the Advancement of Science, 2020.","ista":"Tarrason Risa G, Hurtig F, Bray S, Hafner AE, Harker-Kirschneck L, Faull P, Davis C, Papatziamou D, Mutavchiev DR, Fan C, Meneguello L, Arashiro Pulschen A, Dey G, Culley S, Kilkenny M, Souza DP, Pellegrini L, de Bruin RAM, Henriques R, Snijders AP, Šarić A, Lindås A-C, Robinson NP, Baum B. 2020. The proteasome controls ESCRT-III–mediated cell division in an archaeon. Science. 369(6504).","ama":"Tarrason Risa G, Hurtig F, Bray S, et al. The proteasome controls ESCRT-III–mediated cell division in an archaeon. Science. 2020;369(6504). doi:10.1126/science.aaz2532","apa":"Tarrason Risa, G., Hurtig, F., Bray, S., Hafner, A. E., Harker-Kirschneck, L., Faull, P., … Baum, B. (2020). The proteasome controls ESCRT-III–mediated cell division in an archaeon. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.aaz2532","chicago":"Tarrason Risa, Gabriel, Fredrik Hurtig, Sian Bray, Anne E. Hafner, Lena Harker-Kirschneck, Peter Faull, Colin Davis, et al. “The Proteasome Controls ESCRT-III–Mediated Cell Division in an Archaeon.” Science. American Association for the Advancement of Science, 2020. https://doi.org/10.1126/science.aaz2532."},"article_type":"original","language":[{"iso":"eng"}],"publication_status":"published","year":"2020","month":"08","issue":"6504","volume":369,"author":[{"last_name":"Tarrason Risa","first_name":"Gabriel","full_name":"Tarrason Risa, Gabriel"},{"last_name":"Hurtig","first_name":"Fredrik","full_name":"Hurtig, Fredrik"},{"full_name":"Bray, Sian","first_name":"Sian","last_name":"Bray"},{"first_name":"Anne E.","last_name":"Hafner","full_name":"Hafner, Anne E."},{"full_name":"Harker-Kirschneck, Lena","first_name":"Lena","last_name":"Harker-Kirschneck"},{"full_name":"Faull, Peter","first_name":"Peter","last_name":"Faull"},{"full_name":"Davis, Colin","last_name":"Davis","first_name":"Colin"},{"first_name":"Dimitra","last_name":"Papatziamou","full_name":"Papatziamou, Dimitra"},{"first_name":"Delyan R.","last_name":"Mutavchiev","full_name":"Mutavchiev, Delyan R."},{"first_name":"Catherine","last_name":"Fan","full_name":"Fan, Catherine"},{"last_name":"Meneguello","first_name":"Leticia","full_name":"Meneguello, Leticia"},{"last_name":"Arashiro Pulschen","first_name":"Andre","full_name":"Arashiro Pulschen, Andre"},{"first_name":"Gautam","last_name":"Dey","full_name":"Dey, Gautam"},{"first_name":"Siân","last_name":"Culley","full_name":"Culley, Siân"},{"last_name":"Kilkenny","first_name":"Mairi","full_name":"Kilkenny, Mairi"},{"last_name":"Souza","first_name":"Diorge P.","full_name":"Souza, Diorge P."},{"full_name":"Pellegrini, Luca","last_name":"Pellegrini","first_name":"Luca"},{"full_name":"de Bruin, Robertus A. M.","last_name":"de Bruin","first_name":"Robertus A. M."},{"full_name":"Henriques, Ricardo","first_name":"Ricardo","last_name":"Henriques"},{"first_name":"Ambrosius P.","last_name":"Snijders","full_name":"Snijders, Ambrosius P."},{"last_name":"Šarić","first_name":"Anđela","orcid":"0000-0002-7854-2139","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela"},{"full_name":"Lindås, Ann-Christin","first_name":"Ann-Christin","last_name":"Lindås"},{"full_name":"Robinson, Nicholas P.","last_name":"Robinson","first_name":"Nicholas P."},{"full_name":"Baum, Buzz","first_name":"Buzz","last_name":"Baum"}],"pmid":1}]