[{"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1371/journal.pcbi.1008402","citation":{"chicago":"Kaveh, Kamran, Alex McAvoy, Krishnendu Chatterjee, and Martin A. Nowak. “The Moran Process on 2-Chromatic Graphs.” <i>PLOS Computational Biology</i>. Public Library of Science, 2020. <a href=\"https://doi.org/10.1371/journal.pcbi.1008402\">https://doi.org/10.1371/journal.pcbi.1008402</a>.","short":"K. Kaveh, A. McAvoy, K. Chatterjee, M.A. Nowak, PLOS Computational Biology 16 (2020).","mla":"Kaveh, Kamran, et al. “The Moran Process on 2-Chromatic Graphs.” <i>PLOS Computational Biology</i>, vol. 16, no. 11, e1008402, Public Library of Science, 2020, doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1008402\">10.1371/journal.pcbi.1008402</a>.","ieee":"K. Kaveh, A. McAvoy, K. Chatterjee, and M. A. Nowak, “The Moran process on 2-chromatic graphs,” <i>PLOS Computational Biology</i>, vol. 16, no. 11. Public Library of Science, 2020.","ista":"Kaveh K, McAvoy A, Chatterjee K, Nowak MA. 2020. The Moran process on 2-chromatic graphs. PLOS Computational Biology. 16(11), e1008402.","ama":"Kaveh K, McAvoy A, Chatterjee K, Nowak MA. The Moran process on 2-chromatic graphs. <i>PLOS Computational Biology</i>. 2020;16(11). doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1008402\">10.1371/journal.pcbi.1008402</a>","apa":"Kaveh, K., McAvoy, A., Chatterjee, K., &#38; Nowak, M. A. (2020). The Moran process on 2-chromatic graphs. <i>PLOS Computational Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pcbi.1008402\">https://doi.org/10.1371/journal.pcbi.1008402</a>"},"volume":16,"department":[{"_id":"KrCh"}],"scopus_import":"1","quality_controlled":"1","oa_version":"Published Version","_id":"8767","external_id":{"pmid":["33151935"],"isi":["000591317200004"]},"publication_identifier":{"eissn":["1553-7358"],"issn":["1553-734X"]},"acknowledgement":"We thank Igor Erovenko for many helpful comments on an earlier version of this paper. : Army Research Laboratory (grant W911NF-18-2-0265) (M.A.N.); the Bill & Melinda Gates Foundation (grant OPP1148627) (M.A.N.); the NVIDIA Corporation (A.M.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","file_date_updated":"2020-11-18T07:26:10Z","article_type":"original","day":"05","date_updated":"2025-06-12T07:02:01Z","title":"The Moran process on 2-chromatic graphs","author":[{"last_name":"Kaveh","first_name":"Kamran","full_name":"Kaveh, Kamran"},{"full_name":"McAvoy, Alex","last_name":"McAvoy","first_name":"Alex"},{"first_name":"Krishnendu","orcid":"0000-0002-4561-241X","last_name":"Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","full_name":"Chatterjee, Krishnendu"},{"full_name":"Nowak, Martin A.","last_name":"Nowak","first_name":"Martin A."}],"intvolume":"        16","language":[{"iso":"eng"}],"publisher":"Public Library of Science","date_created":"2020-11-18T07:20:23Z","pmid":1,"abstract":[{"lang":"eng","text":"Resources are rarely distributed uniformly within a population. Heterogeneity in the concentration of a drug, the quality of breeding sites, or wealth can all affect evolutionary dynamics. In this study, we represent a collection of properties affecting the fitness at a given location using a color. A green node is rich in resources while a red node is poorer. More colors can represent a broader spectrum of resource qualities. For a population evolving according to the birth-death Moran model, the first question we address is which structures, identified by graph connectivity and graph coloring, are evolutionarily equivalent. We prove that all properly two-colored, undirected, regular graphs are evolutionarily equivalent (where “properly colored” means that no two neighbors have the same color). We then compare the effects of background heterogeneity on properly two-colored graphs to those with alternative schemes in which the colors are permuted. Finally, we discuss dynamic coloring as a model for spatiotemporal resource fluctuations, and we illustrate that random dynamic colorings often diminish the effects of background heterogeneity relative to a proper two-coloring."}],"has_accepted_license":"1","publication":"PLOS Computational Biology","month":"11","ddc":["000"],"status":"public","issue":"11","oa":1,"isi":1,"type":"journal_article","date_published":"2020-11-05T00:00:00Z","article_number":"e1008402","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"date_updated":"2020-11-18T07:26:10Z","file_id":"8768","success":1,"file_size":2498594,"access_level":"open_access","content_type":"application/pdf","date_created":"2020-11-18T07:26:10Z","relation":"main_file","checksum":"555456dd0e47bcf9e0994bcb95577e88","file_name":"2020_PlosCompBio_Kaveh.pdf","creator":"dernst"}],"year":"2020","keyword":["Ecology","Modelling and Simulation","Computational Theory and Mathematics","Genetics","Ecology","Evolution","Behavior and Systematics","Molecular Biology","Cellular and Molecular Neuroscience"],"article_processing_charge":"No","publication_status":"published"},{"_id":"8769","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1912.07890"}],"oa_version":"Preprint","quality_controlled":"1","scopus_import":"1","department":[{"_id":"MiLe"},{"_id":"RoSe"}],"volume":102,"project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"name":"Analysis of quantum many-body systems","grant_number":"694227","call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","_id":"2688CF98-B435-11E9-9278-68D0E5697425","name":"Angulon: physics and applications of a new quasiparticle","grant_number":"801770"}],"doi":"10.1103/physrevb.102.144109","citation":{"chicago":"Yakaboylu, Enderalp, Areg Ghazaryan, D. Lundholm, N. Rougerie, Mikhail Lemeshko, and Robert Seiringer. “Quantum Impurity Model for Anyons.” <i>Physical Review B</i>. American Physical Society, 2020. <a href=\"https://doi.org/10.1103/physrevb.102.144109\">https://doi.org/10.1103/physrevb.102.144109</a>.","short":"E. Yakaboylu, A. Ghazaryan, D. Lundholm, N. Rougerie, M. Lemeshko, R. Seiringer, Physical Review B 102 (2020).","mla":"Yakaboylu, Enderalp, et al. “Quantum Impurity Model for Anyons.” <i>Physical Review B</i>, vol. 102, no. 14, 144109, American Physical Society, 2020, doi:<a href=\"https://doi.org/10.1103/physrevb.102.144109\">10.1103/physrevb.102.144109</a>.","ieee":"E. Yakaboylu, A. Ghazaryan, D. Lundholm, N. Rougerie, M. Lemeshko, and R. Seiringer, “Quantum impurity model for anyons,” <i>Physical Review B</i>, vol. 102, no. 14. American Physical Society, 2020.","ista":"Yakaboylu E, Ghazaryan A, Lundholm D, Rougerie N, Lemeshko M, Seiringer R. 2020. Quantum impurity model for anyons. Physical Review B. 102(14), 144109.","apa":"Yakaboylu, E., Ghazaryan, A., Lundholm, D., Rougerie, N., Lemeshko, M., &#38; Seiringer, R. (2020). Quantum impurity model for anyons. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevb.102.144109\">https://doi.org/10.1103/physrevb.102.144109</a>","ama":"Yakaboylu E, Ghazaryan A, Lundholm D, Rougerie N, Lemeshko M, Seiringer R. Quantum impurity model for anyons. <i>Physical Review B</i>. 2020;102(14). doi:<a href=\"https://doi.org/10.1103/physrevb.102.144109\">10.1103/physrevb.102.144109</a>"},"author":[{"last_name":"Yakaboylu","orcid":"0000-0001-5973-0874","first_name":"Enderalp","full_name":"Yakaboylu, Enderalp","id":"38CB71F6-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Ghazaryan, Areg","id":"4AF46FD6-F248-11E8-B48F-1D18A9856A87","last_name":"Ghazaryan","orcid":"0000-0001-9666-3543","first_name":"Areg"},{"last_name":"Lundholm","first_name":"D.","full_name":"Lundholm, D."},{"first_name":"N.","last_name":"Rougerie","full_name":"Rougerie, N."},{"first_name":"Mikhail","last_name":"Lemeshko","orcid":"0000-0002-6990-7802","full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Seiringer","orcid":"0000-0002-6781-0521","first_name":"Robert","full_name":"Seiringer, Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"date_updated":"2025-04-14T07:26:54Z","title":"Quantum impurity model for anyons","article_type":"original","publication_identifier":{"eissn":["2469-9969"],"issn":["2469-9950"]},"acknowledgement":"We are grateful to M. Correggi, A. Deuchert, and P. Schmelcher for valuable discussions. We also thank the anonymous referees for helping to clarify a few important points in the experimental realization. A.G. acknowledges support by the European Unions Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement\r\nNo 754411. D.L. acknowledges financial support from the Goran Gustafsson Foundation (grant no. 1804) and LMU Munich. R.S., M.L., and N.R. gratefully acknowledge financial support by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreements No 694227, No 801770, and No 758620, respectively).","day":"01","arxiv":1,"external_id":{"isi":["000582563300001"],"arxiv":["1912.07890"]},"issue":"14","status":"public","month":"10","publication":"Physical Review B","date_created":"2020-11-18T07:34:17Z","abstract":[{"lang":"eng","text":"One of the hallmarks of quantum statistics, tightly entwined with the concept of topological phases of matter, is the prediction of anyons. Although anyons are predicted to be realized in certain fractional quantum Hall systems, they have not yet been unambiguously detected in experiment. Here we introduce a simple quantum impurity model, where bosonic or fermionic impurities turn into anyons as a consequence of their interaction with the surrounding many-particle bath. A cloud of phonons dresses each impurity in such a way that it effectively attaches fluxes or vortices to it and thereby converts it into an Abelian anyon. The corresponding quantum impurity model, first, provides a different approach to the numerical solution of the many-anyon problem, along with a concrete perspective of anyons as emergent quasiparticles built from composite bosons or fermions. More importantly, the model paves the way toward realizing anyons using impurities in crystal lattices as well as ultracold gases. In particular, we consider two heavy electrons interacting with a two-dimensional lattice crystal in a magnetic field, and show that when the impurity-bath system is rotated at the cyclotron frequency, impurities behave as anyons as a consequence of the angular momentum exchange between the impurities and the bath. A possible experimental realization is proposed by identifying the statistics parameter in terms of the mean-square distance of the impurities and the magnetization of the impurity-bath system, both of which are accessible to experiment. Another proposed application is impurities immersed in a two-dimensional weakly interacting Bose gas."}],"publisher":"American Physical Society","language":[{"iso":"eng"}],"intvolume":"       102","article_processing_charge":"No","year":"2020","publication_status":"published","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","article_number":"144109","date_published":"2020-10-01T00:00:00Z","ec_funded":1,"type":"journal_article","isi":1,"oa":1},{"date_updated":"2026-04-02T11:48:21Z","title":"Vascular surveillance by haptotactic blood platelets in inflammation and infection","author":[{"first_name":"Leo","last_name":"Nicolai","full_name":"Nicolai, Leo"},{"last_name":"Schiefelbein","first_name":"Karin","full_name":"Schiefelbein, Karin"},{"last_name":"Lipsky","first_name":"Silvia","full_name":"Lipsky, Silvia"},{"first_name":"Alexander","last_name":"Leunig","full_name":"Leunig, Alexander"},{"first_name":"Marie","last_name":"Hoffknecht","full_name":"Hoffknecht, Marie"},{"full_name":"Pekayvaz, Kami","first_name":"Kami","last_name":"Pekayvaz"},{"full_name":"Raude, Ben","first_name":"Ben","last_name":"Raude"},{"first_name":"Charlotte","last_name":"Marx","full_name":"Marx, Charlotte"},{"first_name":"Andreas","last_name":"Ehrlich","full_name":"Ehrlich, Andreas"},{"full_name":"Pircher, Joachim","last_name":"Pircher","first_name":"Joachim"},{"first_name":"Zhe","last_name":"Zhang","full_name":"Zhang, Zhe"},{"full_name":"Saleh, Inas","first_name":"Inas","last_name":"Saleh"},{"full_name":"Marel, Anna-Kristina","last_name":"Marel","first_name":"Anna-Kristina"},{"full_name":"Löf, Achim","last_name":"Löf","first_name":"Achim"},{"last_name":"Petzold","first_name":"Tobias","full_name":"Petzold, Tobias"},{"full_name":"Lorenz, Michael","last_name":"Lorenz","first_name":"Michael"},{"full_name":"Stark, Konstantin","last_name":"Stark","first_name":"Konstantin"},{"last_name":"Pick","first_name":"Robert","full_name":"Pick, Robert"},{"full_name":"Rosenberger, Gerhild","first_name":"Gerhild","last_name":"Rosenberger"},{"first_name":"Ludwig","last_name":"Weckbach","full_name":"Weckbach, Ludwig"},{"full_name":"Uhl, Bernd","last_name":"Uhl","first_name":"Bernd"},{"full_name":"Xia, Sheng","last_name":"Xia","first_name":"Sheng"},{"full_name":"Reichel, Christoph Andreas","last_name":"Reichel","first_name":"Christoph Andreas"},{"full_name":"Walzog, Barbara","first_name":"Barbara","last_name":"Walzog"},{"last_name":"Schulz","first_name":"Christian","full_name":"Schulz, Christian"},{"first_name":"Vanessa","last_name":"Zheden","orcid":"0000-0002-9438-4783","full_name":"Zheden, Vanessa","id":"39C5A68A-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Markus","last_name":"Bender","full_name":"Bender, Markus"},{"full_name":"Li, Rong","last_name":"Li","first_name":"Rong"},{"full_name":"Massberg, Steffen","last_name":"Massberg","first_name":"Steffen"},{"full_name":"Gärtner, Florian R","id":"397A88EE-F248-11E8-B48F-1D18A9856A87","last_name":"Gärtner","orcid":"0000-0001-6120-3723","first_name":"Florian R"}],"external_id":{"isi":["000594648000014"],"pmid":["33188196"]},"article_type":"original","related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41467-022-31310-7"}]},"acknowledgement":"We thank Sebastian Helmer, Nicole Blount, Christine Mann, and Beate Jantz for technical assistance; Hellen Ishikawa-Ankerhold for help and advice; Michael Sixt for critical\r\ndiscussions. This study was supported by the DFG SFB 914 (S.M. [B02 and Z01], K.Sch.\r\n[B02], B.W. [A02 and Z03], C.A.R. [B03], C.S. [A10], J.P. [Gerok position]), the DFG\r\nSFB 1123 (S.M. [B06]), the DFG FOR 2033 (S.M. and F.G.), the German Center for\r\nCardiovascular Research (DZHK) (Clinician Scientist Program [L.N.], MHA 1.4VD\r\n[S.M.], Postdoc Start-up Grant, 81×3600213 [F.G.]), FP7 program (project 260309,\r\nPRESTIGE [S.M.]), FöFoLe project 1015/1009 (L.N.), FöFoLe project 947 (F.G.), the\r\nFriedrich-Baur-Stiftung project 41/16 (F.G.), and LMUexcellence NFF (F.G.). This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no.\r\n833440) (S.M.). F.G. received funding from the European Union’s Horizon 2020 research\r\nand innovation program under the Marie Skłodowska-Curie grant agreement no.\r\n747687.","file_date_updated":"2020-11-23T13:29:49Z","publication_identifier":{"eissn":["2041-1723"]},"day":"13","quality_controlled":"1","oa_version":"Published Version","_id":"8787","doi":"10.1038/s41467-020-19515-0","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"citation":{"mla":"Nicolai, Leo, et al. “Vascular Surveillance by Haptotactic Blood Platelets in Inflammation and Infection.” <i>Nature Communications</i>, vol. 11, 5778, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-19515-0\">10.1038/s41467-020-19515-0</a>.","ieee":"L. Nicolai <i>et al.</i>, “Vascular surveillance by haptotactic blood platelets in inflammation and infection,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","ista":"Nicolai L, Schiefelbein K, Lipsky S, Leunig A, Hoffknecht M, Pekayvaz K, Raude B, Marx C, Ehrlich A, Pircher J, Zhang Z, Saleh I, Marel A-K, Löf A, Petzold T, Lorenz M, Stark K, Pick R, Rosenberger G, Weckbach L, Uhl B, Xia S, Reichel CA, Walzog B, Schulz C, Zheden V, Bender M, Li R, Massberg S, Gärtner FR. 2020. Vascular surveillance by haptotactic blood platelets in inflammation and infection. Nature Communications. 11, 5778.","apa":"Nicolai, L., Schiefelbein, K., Lipsky, S., Leunig, A., Hoffknecht, M., Pekayvaz, K., … Gärtner, F. R. (2020). Vascular surveillance by haptotactic blood platelets in inflammation and infection. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-19515-0\">https://doi.org/10.1038/s41467-020-19515-0</a>","ama":"Nicolai L, Schiefelbein K, Lipsky S, et al. Vascular surveillance by haptotactic blood platelets in inflammation and infection. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-19515-0\">10.1038/s41467-020-19515-0</a>","chicago":"Nicolai, Leo, Karin Schiefelbein, Silvia Lipsky, Alexander Leunig, Marie Hoffknecht, Kami Pekayvaz, Ben Raude, et al. “Vascular Surveillance by Haptotactic Blood Platelets in Inflammation and Infection.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-19515-0\">https://doi.org/10.1038/s41467-020-19515-0</a>.","short":"L. Nicolai, K. Schiefelbein, S. Lipsky, A. Leunig, M. Hoffknecht, K. Pekayvaz, B. Raude, C. Marx, A. Ehrlich, J. Pircher, Z. Zhang, I. Saleh, A.-K. Marel, A. Löf, T. Petzold, M. Lorenz, K. Stark, R. Pick, G. Rosenberger, L. Weckbach, B. Uhl, S. Xia, C.A. Reichel, B. Walzog, C. Schulz, V. Zheden, M. Bender, R. Li, S. Massberg, F.R. Gärtner, Nature Communications 11 (2020)."},"project":[{"_id":"260AA4E2-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"747687","name":"Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells"}],"volume":11,"department":[{"_id":"MiSi"},{"_id":"EM-Fac"}],"scopus_import":"1","date_published":"2020-11-13T00:00:00Z","article_number":"5778","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","file":[{"content_type":"application/pdf","access_level":"open_access","file_size":7035340,"creator":"dernst","checksum":"485b7b6cf30198ba0ce126491a28f125","file_name":"2020_NatureComm_Nicolai.pdf","relation":"main_file","date_created":"2020-11-23T13:29:49Z","date_updated":"2020-11-23T13:29:49Z","success":1,"file_id":"8798"}],"article_processing_charge":"No","year":"2020","publication_status":"published","oa":1,"isi":1,"type":"journal_article","ec_funded":1,"ddc":["570"],"publication":"Nature Communications","corr_author":"1","month":"11","status":"public","intvolume":"        11","language":[{"iso":"eng"}],"publisher":"Springer Nature","pmid":1,"date_created":"2020-11-22T23:01:23Z","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Breakdown of vascular barriers is a major complication of inflammatory diseases. Anucleate platelets form blood-clots during thrombosis, but also play a crucial role in inflammation. While spatio-temporal dynamics of clot formation are well characterized, the cell-biological mechanisms of platelet recruitment to inflammatory micro-environments remain incompletely understood. Here we identify Arp2/3-dependent lamellipodia formation as a prominent morphological feature of immune-responsive platelets. Platelets use lamellipodia to scan for fibrin(ogen) deposited on the inflamed vasculature and to directionally spread, to polarize and to govern haptotactic migration along gradients of the adhesive ligand. Platelet-specific abrogation of Arp2/3 interferes with haptotactic repositioning of platelets to microlesions, thus impairing vascular sealing and provoking inflammatory microbleeding. During infection, haptotaxis promotes capture of bacteria and prevents hematogenic dissemination, rendering platelets gate-keepers of the inflamed microvasculature. Consequently, these findings identify haptotaxis as a key effector function of immune-responsive platelets."}]},{"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2020-11-04T00:00:00Z","article_number":"1945","publication_status":"published","year":"2020","article_processing_charge":"No","file":[{"date_updated":"2020-11-23T13:06:30Z","file_id":"8797","success":1,"access_level":"open_access","content_type":"application/pdf","file_size":565191,"file_name":"2020_Mathematics_Kleshnina.pdf","checksum":"61cfcc3b35760656ce7a9385a4ace5d2","creator":"dernst","date_created":"2020-11-23T13:06:30Z","relation":"main_file"}],"type":"journal_article","isi":1,"ec_funded":1,"oa":1,"publication":"Mathematics","status":"public","month":"11","corr_author":"1","ddc":["000"],"issue":"11","language":[{"iso":"eng"}],"intvolume":"         8","abstract":[{"text":"Cooperation is a ubiquitous and beneficial behavioural trait despite being prone to exploitation by free-riders. Hence, cooperative populations are prone to invasions by selfish individuals. However, a population consisting of only free-riders typically does not survive. Thus, cooperators and free-riders often coexist in some proportion. An evolutionary version of a Snowdrift Game proved its efficiency in analysing this phenomenon. However, what if the system has already reached its stable state but was perturbed due to a change in environmental conditions? Then, individuals may have to re-learn their effective strategies. To address this, we consider behavioural mistakes in strategic choice execution, which we refer to as incompetence. Parametrising the propensity to make such mistakes allows for a mathematical description of learning. We compare strategies based on their relative strategic advantage relying on both fitness and learning factors. When strategies are learned at distinct rates, allowing learning according to a prescribed order is optimal. Interestingly, the strategy with the lowest strategic advantage should be learnt first if we are to optimise fitness over the learning path. Then, the differences between strategies are balanced out in order to minimise the effect of behavioural uncertainty.","lang":"eng"}],"date_created":"2020-11-22T23:01:24Z","has_accepted_license":"1","publisher":"MDPI","title":"Prioritised learning in snowdrift-type games","date_updated":"2026-04-07T08:37:03Z","author":[{"first_name":"Maria","orcid":"0000-0002-5518-8317","last_name":"Kleshnina","id":"4E21749C-F248-11E8-B48F-1D18A9856A87","full_name":"Kleshnina, Maria"},{"full_name":"Streipert, Sabrina","last_name":"Streipert","first_name":"Sabrina"},{"first_name":"Jerzy","last_name":"Filar","full_name":"Filar, Jerzy"},{"first_name":"Krishnendu","last_name":"Chatterjee","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"}],"external_id":{"isi":["000593962100001"]},"day":"04","acknowledgement":"This work was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement #754411, the Australian Research Council Discovery Grants DP160101236 and DP150100618, and the European Research Council Consolidator Grant 863818 (FoRM-SMArt).\r\nAuthors would like to thank Patrick McKinlay for his work on the preliminary results for this paper.","file_date_updated":"2020-11-23T13:06:30Z","article_type":"original","publication_identifier":{"eissn":["2227-7390"]},"_id":"8789","quality_controlled":"1","oa_version":"Published Version","project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"grant_number":"863818","name":"Formal Methods for Stochastic Models: Algorithms and Applications","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020"}],"doi":"10.3390/math8111945","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"citation":{"chicago":"Kleshnina, Maria, Sabrina Streipert, Jerzy Filar, and Krishnendu Chatterjee. “Prioritised Learning in Snowdrift-Type Games.” <i>Mathematics</i>. MDPI, 2020. <a href=\"https://doi.org/10.3390/math8111945\">https://doi.org/10.3390/math8111945</a>.","short":"M. Kleshnina, S. Streipert, J. Filar, K. Chatterjee, Mathematics 8 (2020).","ieee":"M. Kleshnina, S. Streipert, J. Filar, and K. Chatterjee, “Prioritised learning in snowdrift-type games,” <i>Mathematics</i>, vol. 8, no. 11. MDPI, 2020.","mla":"Kleshnina, Maria, et al. “Prioritised Learning in Snowdrift-Type Games.” <i>Mathematics</i>, vol. 8, no. 11, 1945, MDPI, 2020, doi:<a href=\"https://doi.org/10.3390/math8111945\">10.3390/math8111945</a>.","ista":"Kleshnina M, Streipert S, Filar J, Chatterjee K. 2020. Prioritised learning in snowdrift-type games. Mathematics. 8(11), 1945.","apa":"Kleshnina, M., Streipert, S., Filar, J., &#38; Chatterjee, K. (2020). Prioritised learning in snowdrift-type games. <i>Mathematics</i>. MDPI. <a href=\"https://doi.org/10.3390/math8111945\">https://doi.org/10.3390/math8111945</a>","ama":"Kleshnina M, Streipert S, Filar J, Chatterjee K. Prioritised learning in snowdrift-type games. <i>Mathematics</i>. 2020;8(11). doi:<a href=\"https://doi.org/10.3390/math8111945\">10.3390/math8111945</a>"},"scopus_import":"1","department":[{"_id":"KrCh"}],"volume":8},{"OA_type":"hybrid","language":[{"iso":"eng"}],"intvolume":"        39","abstract":[{"text":"Reachability analysis aims at identifying states reachable by a system within a given time horizon. This task is known to be computationally expensive for linear hybrid systems. Reachability analysis works by iteratively applying continuous and discrete post operators to compute states reachable according to continuous and discrete dynamics, respectively. In this article, we enhance both of these operators and make sure that most of the involved computations are performed in low-dimensional state space. In particular, we improve the continuous-post operator by performing computations in high-dimensional state space only for time intervals relevant for the subsequent application of the discrete-post operator. Furthermore, the new discrete-post operator performs low-dimensional computations by leveraging the structure of the guard and assignment of a considered transition. We illustrate the potential of our approach on a number of challenging benchmarks.","lang":"eng"}],"date_created":"2020-11-22T23:01:25Z","publisher":"IEEE","publication":"IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems","month":"11","status":"public","issue":"11","ec_funded":1,"type":"journal_article","isi":1,"oa":1,"page":"4018-4029","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2020-11-01T00:00:00Z","year":"2020","article_processing_charge":"No","publication_status":"published","project":[{"call_identifier":"FWF","_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","grant_number":"S 11407_N23"},{"grant_number":"Z211","name":"Formal methods for the design and analysis of complex systems","_id":"25F42A32-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"citation":{"short":"S. Bogomolov, M. Forets, G. Frehse, K. Potomkin, C. Schilling, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 39 (2020) 4018–4029.","chicago":"Bogomolov, Sergiy, Marcelo Forets, Goran Frehse, Kostiantyn Potomkin, and Christian Schilling. “Reachability Analysis of Linear Hybrid Systems via Block Decomposition.” <i>IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems</i>. IEEE, 2020. <a href=\"https://doi.org/10.1109/TCAD.2020.3012859\">https://doi.org/10.1109/TCAD.2020.3012859</a>.","ama":"Bogomolov S, Forets M, Frehse G, Potomkin K, Schilling C. Reachability analysis of linear hybrid systems via block decomposition. <i>IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems</i>. 2020;39(11):4018-4029. doi:<a href=\"https://doi.org/10.1109/TCAD.2020.3012859\">10.1109/TCAD.2020.3012859</a>","apa":"Bogomolov, S., Forets, M., Frehse, G., Potomkin, K., &#38; Schilling, C. (2020). Reachability analysis of linear hybrid systems via block decomposition. <i>IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems</i>. IEEE. <a href=\"https://doi.org/10.1109/TCAD.2020.3012859\">https://doi.org/10.1109/TCAD.2020.3012859</a>","ista":"Bogomolov S, Forets M, Frehse G, Potomkin K, Schilling C. 2020. Reachability analysis of linear hybrid systems via block decomposition. IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems. 39(11), 4018–4029.","ieee":"S. Bogomolov, M. Forets, G. Frehse, K. Potomkin, and C. Schilling, “Reachability analysis of linear hybrid systems via block decomposition,” <i>IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems</i>, vol. 39, no. 11. IEEE, pp. 4018–4029, 2020.","mla":"Bogomolov, Sergiy, et al. “Reachability Analysis of Linear Hybrid Systems via Block Decomposition.” <i>IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems</i>, vol. 39, no. 11, IEEE, 2020, pp. 4018–29, doi:<a href=\"https://doi.org/10.1109/TCAD.2020.3012859\">10.1109/TCAD.2020.3012859</a>."},"doi":"10.1109/TCAD.2020.3012859","scopus_import":"1","department":[{"_id":"ToHe"}],"volume":39,"_id":"8790","main_file_link":[{"url":"https://arxiv.org/abs/1905.02458","open_access":"1"}],"quality_controlled":"1","oa_version":"Preprint","OA_place":"publisher","external_id":{"arxiv":["1905.02458"],"isi":["000587712700072"]},"article_type":"original","publication_identifier":{"issn":["0278-0070"],"eissn":["1937-4151"]},"acknowledgement":"This research was supported in part by the Austrian Science Fund (FWF) under grants S11402-N23 (RiSE/SHiNE) and Z211-N23 (Wittgenstein Award), the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754411, and the Air Force Office of Scientific Research under award number FA2386-17-1-4065. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the United States Air Force. ","related_material":{"record":[{"relation":"earlier_version","id":"8287","status":"public"}]},"day":"01","arxiv":1,"date_updated":"2026-04-03T09:32:00Z","title":"Reachability analysis of linear hybrid systems via block decomposition","author":[{"last_name":"Bogomolov","orcid":"0000-0002-0686-0365","first_name":"Sergiy","full_name":"Bogomolov, Sergiy","id":"369D9A44-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Forets, Marcelo","last_name":"Forets","first_name":"Marcelo"},{"full_name":"Frehse, Goran","first_name":"Goran","last_name":"Frehse"},{"full_name":"Potomkin, Kostiantyn","first_name":"Kostiantyn","last_name":"Potomkin"},{"first_name":"Christian","orcid":"0000-0003-3658-1065","last_name":"Schilling","id":"3A2F4DCE-F248-11E8-B48F-1D18A9856A87","full_name":"Schilling, Christian"}]},{"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","title":"Data from: Assortative mating, sexual selection and their consequences for gene flow in Littorina","date_updated":"2025-07-10T11:54:59Z","date_published":"2020-07-01T00:00:00Z","article_processing_charge":"No","year":"2020","author":[{"full_name":"Perini, Samuel","first_name":"Samuel","last_name":"Perini"},{"full_name":"Rafajlovic, Marina","last_name":"Rafajlovic","first_name":"Marina"},{"full_name":"Westram, Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87","last_name":"Westram","orcid":"0000-0003-1050-4969","first_name":"Anja M"},{"first_name":"Kerstin","last_name":"Johannesson","full_name":"Johannesson, Kerstin"},{"full_name":"Butlin, Roger","last_name":"Butlin","first_name":"Roger"}],"type":"research_data_reference","license":"https://creativecommons.org/publicdomain/zero/1.0/","oa":1,"day":"01","related_material":{"record":[{"status":"public","id":"7995","relation":"used_in_publication"}]},"_id":"8809","status":"public","oa_version":"Published Version","month":"07","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.qrfj6q5cn"}],"tmp":{"short":"CC0 (1.0)","name":"Creative Commons Public Domain Dedication (CC0 1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","image":"/images/cc_0.png"},"citation":{"chicago":"Perini, Samuel, Marina Rafajlovic, Anja M Westram, Kerstin Johannesson, and Roger Butlin. “Data from: Assortative Mating, Sexual Selection and Their Consequences for Gene Flow in Littorina.” Dryad, 2020. <a href=\"https://doi.org/10.5061/dryad.qrfj6q5cn\">https://doi.org/10.5061/dryad.qrfj6q5cn</a>.","short":"S. Perini, M. Rafajlovic, A.M. Westram, K. Johannesson, R. Butlin, (2020).","ieee":"S. Perini, M. Rafajlovic, A. M. Westram, K. Johannesson, and R. Butlin, “Data from: Assortative mating, sexual selection and their consequences for gene flow in Littorina.” Dryad, 2020.","mla":"Perini, Samuel, et al. <i>Data from: Assortative Mating, Sexual Selection and Their Consequences for Gene Flow in Littorina</i>. Dryad, 2020, doi:<a href=\"https://doi.org/10.5061/dryad.qrfj6q5cn\">10.5061/dryad.qrfj6q5cn</a>.","ista":"Perini S, Rafajlovic M, Westram AM, Johannesson K, Butlin R. 2020. Data from: Assortative mating, sexual selection and their consequences for gene flow in Littorina, Dryad, <a href=\"https://doi.org/10.5061/dryad.qrfj6q5cn\">10.5061/dryad.qrfj6q5cn</a>.","apa":"Perini, S., Rafajlovic, M., Westram, A. M., Johannesson, K., &#38; Butlin, R. (2020). Data from: Assortative mating, sexual selection and their consequences for gene flow in Littorina. Dryad. <a href=\"https://doi.org/10.5061/dryad.qrfj6q5cn\">https://doi.org/10.5061/dryad.qrfj6q5cn</a>","ama":"Perini S, Rafajlovic M, Westram AM, Johannesson K, Butlin R. Data from: Assortative mating, sexual selection and their consequences for gene flow in Littorina. 2020. doi:<a href=\"https://doi.org/10.5061/dryad.qrfj6q5cn\">10.5061/dryad.qrfj6q5cn</a>"},"doi":"10.5061/dryad.qrfj6q5cn","date_created":"2020-11-25T11:07:25Z","department":[{"_id":"NiBa"}],"abstract":[{"text":"When divergent populations are connected by gene flow, the establishment of complete reproductive isolation usually requires the joint action of multiple barrier effects. One example where multiple barrier effects are coupled consists of a single trait that is under divergent natural selection and also mediates assortative mating. Such multiple-effect traits can strongly reduce gene flow. However, there are few cases where patterns of assortative mating have been described quantitatively and their impact on gene flow has been determined. Two ecotypes of the coastal marine snail, Littorina saxatilis, occur in North Atlantic rocky-shore habitats dominated by either crab predation or wave action. There is evidence for divergent natural selection acting on size, and size-assortative mating has previously been documented. Here, we analyze the mating pattern in L. saxatilis with respect to size in intensively-sampled transects across boundaries between the habitats. We show that the mating pattern is mostly conserved between ecotypes and that it generates both assortment and directional sexual selection for small male size. Using simulations, we show that the mating pattern can contribute to reproductive isolation between ecotypes but the barrier to gene flow is likely strengthened more by sexual selection than by assortment.","lang":"eng"}],"has_accepted_license":"1","publisher":"Dryad"},{"oa":1,"type":"research_data","contributor":[{"contributor_type":"project_member","id":"b22ab905-3539-11eb-84c3-fc159dcd79cb","last_name":"Aggarwal","first_name":"Kushagra"},{"first_name":"Andrea C","last_name":"Hofmann","id":"340F461A-F248-11E8-B48F-1D18A9856A87","contributor_type":"project_member"},{"first_name":"Daniel","last_name":"Jirovec","id":"4C473F58-F248-11E8-B48F-1D18A9856A87","contributor_type":"project_member"},{"contributor_type":"project_member","id":"2A307FE2-F248-11E8-B48F-1D18A9856A87","last_name":"Prieto Gonzalez","first_name":"Ivan"},{"contributor_type":"project_member","last_name":"Sammak","first_name":"Amir"},{"contributor_type":"project_member","first_name":"Marc","last_name":"Botifoll"},{"first_name":"Sara","last_name":"Marti-Sanchez","contributor_type":"project_member"},{"contributor_type":"project_member","last_name":"Veldhorst","first_name":"Menno"},{"last_name":"Arbiol","first_name":"Jordi","contributor_type":"project_member"},{"last_name":"Scappucci","first_name":"Giordano","contributor_type":"project_member"},{"contributor_type":"project_leader","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","last_name":"Katsaros","first_name":"Georgios"}],"day":"02","related_material":{"record":[{"relation":"used_in_publication","id":"10559","status":"public"},{"id":"8831","relation":"used_in_publication","status":"public"}]},"file_date_updated":"2020-12-02T10:46:27Z","title":"Enhancement of proximity induced superconductivity in planar Germanium","date_published":"2020-12-02T00:00:00Z","date_updated":"2025-04-15T08:38:16Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Katsaros, Georgios","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","last_name":"Katsaros","orcid":"0000-0001-8342-202X","first_name":"Georgios"}],"file":[{"file_size":898039,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:21Z","creator":"gkatsaro","file_name":"Figure1-ICvsVG.hdf5","checksum":"898607ac9d7cfbd5c7dd84bcb6d8a924","date_updated":"2020-12-02T10:46:21Z","success":1,"file_id":"8836"},{"access_level":"open_access","content_type":"application/octet-stream","file_size":184971,"file_name":"Figure1-RNvsVG.hdf5","creator":"gkatsaro","checksum":"f6f5888f8425e82b4dcd5ec3db9162a6","date_created":"2020-12-02T10:46:21Z","relation":"main_file","date_updated":"2020-12-02T10:46:21Z","success":1,"file_id":"8837"},{"file_id":"8838","success":1,"date_updated":"2020-12-02T10:46:22Z","checksum":"63a26c4b0299538610ec58c48c0ab1e3","creator":"gkatsaro","file_name":"Figure2-MAR.hdf5","relation":"main_file","date_created":"2020-12-02T10:46:22Z","content_type":"application/octet-stream","access_level":"open_access","file_size":2097740},{"file_id":"8839","success":1,"date_updated":"2020-12-02T10:46:22Z","creator":"gkatsaro","checksum":"4c6795b64b05088606ab7881f801acd7","file_name":"Figure3-Fraunhofer.hdf5","relation":"main_file","date_created":"2020-12-02T10:46:22Z","content_type":"application/octet-stream","access_level":"open_access","file_size":911501},{"date_updated":"2020-12-02T10:46:22Z","success":1,"file_id":"8840","file_size":384239,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:22Z","relation":"main_file","file_name":"Figure3-ICvsBparallel.hdf5","checksum":"6b1b07e8ab0d6c1fead91032bf543818","creator":"gkatsaro"},{"content_type":"application/octet-stream","access_level":"open_access","file_size":942878,"creator":"gkatsaro","file_name":"Figure3-ICvsBperp.hdf5","checksum":"d825f77f57cbf455a4ac48afeec27f5b","relation":"main_file","date_created":"2020-12-02T10:46:22Z","date_updated":"2020-12-02T10:46:22Z","success":1,"file_id":"8841"},{"relation":"main_file","date_created":"2020-12-02T10:46:22Z","creator":"gkatsaro","file_name":"Figure4-CPR.hdf5","checksum":"ec81afc3697da097a224e9142322243c","file_size":623246,"content_type":"application/octet-stream","access_level":"open_access","success":1,"file_id":"8842","date_updated":"2020-12-02T10:46:22Z"},{"access_level":"open_access","content_type":"application/octet-stream","file_size":507164,"creator":"gkatsaro","file_name":"Figure4-SQUID.hdf5","checksum":"ca5860a8850a6874312c4ca1d7d41013","date_created":"2020-12-02T10:46:22Z","relation":"main_file","date_updated":"2020-12-02T10:46:22Z","success":1,"file_id":"8843"},{"date_updated":"2020-12-02T10:46:22Z","success":1,"file_id":"8844","access_level":"open_access","content_type":"text/plain","file_size":1573,"creator":"gkatsaro","file_name":"Readme.txt","checksum":"770721205d081c847316d9122c94eb9b","date_created":"2020-12-02T10:46:22Z","relation":"main_file"},{"checksum":"5e2e407ca631fb15b8c3cc51c5dd3bdb","creator":"gkatsaro","file_name":"Figure S5-ICvsVG.hdf5","relation":"main_file","date_created":"2020-12-02T10:46:22Z","content_type":"application/octet-stream","access_level":"open_access","file_size":842702,"file_id":"8845","success":1,"date_updated":"2020-12-02T10:46:22Z"},{"access_level":"open_access","content_type":"application/octet-stream","file_size":208921,"creator":"gkatsaro","file_name":"Figure S5-RNvsVG.hdf5","checksum":"2076e5f68264ed76c297811f449d768d","date_created":"2020-12-02T10:46:22Z","relation":"main_file","date_updated":"2020-12-02T10:46:22Z","success":1,"file_id":"8846"},{"file_size":912249,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:22Z","relation":"main_file","checksum":"5dccb801d694749fe8cb496821f12f79","file_name":"Figure S8-ICvsVG.hdf5","creator":"gkatsaro","date_updated":"2020-12-02T10:46:22Z","file_id":"8847","success":1},{"date_updated":"2020-12-02T10:46:22Z","file_id":"8848","success":1,"content_type":"application/octet-stream","access_level":"open_access","file_size":230550,"creator":"gkatsaro","checksum":"2b104aee4276e594c0d50557ead36441","file_name":"Figure S8-RNvsVG.hdf5","relation":"main_file","date_created":"2020-12-02T10:46:22Z"},{"date_updated":"2020-12-02T10:46:23Z","success":1,"file_id":"8849","file_size":533581,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:23Z","relation":"main_file","file_name":"Figure S9-JoFET1-Fraunhofer.hdf5","creator":"gkatsaro","checksum":"1645b03bdc6999d120c3fcc7012c6984"},{"date_updated":"2020-12-02T10:46:23Z","success":1,"file_id":"8850","file_size":1394384,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:23Z","relation":"main_file","creator":"gkatsaro","file_name":"Figure S9-JoFET1-ICvsVG.hdf5","checksum":"7ba623bbee93e8cb5645c4866f241d43"},{"access_level":"open_access","content_type":"application/octet-stream","file_size":548051,"file_name":"Figure S9-JoFET2-Fraunhofer.hdf5","creator":"gkatsaro","checksum":"3b65ccb68cea8d3c30832fc77aa9eea3","date_created":"2020-12-02T10:46:23Z","relation":"main_file","date_updated":"2020-12-02T10:46:23Z","success":1,"file_id":"8851"},{"date_updated":"2020-12-02T10:46:23Z","file_id":"8852","success":1,"file_size":112602,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:23Z","file_name":"Figure S9-JoFET2-ICvsVG.hdf5","checksum":"3d7394a7bc8ff08bcc7928262514d2b9","creator":"gkatsaro"},{"file_id":"8853","success":1,"date_updated":"2020-12-02T10:46:23Z","checksum":"2ef8b3226a99fc65cad1162a52552848","creator":"gkatsaro","file_name":"Readme.txt","relation":"main_file","date_created":"2020-12-02T10:46:23Z","content_type":"text/plain","access_level":"open_access","file_size":1449},{"date_updated":"2020-12-02T10:46:23Z","file_id":"8854","success":1,"file_size":149502,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:23Z","relation":"main_file","file_name":"dev2-jj2-ICvsVG-Tdependence_1000mK.hdf5","checksum":"361ef6521f6b23223a34f8cf9645ee68","creator":"gkatsaro"},{"success":1,"file_id":"8855","date_updated":"2020-12-02T10:46:23Z","checksum":"f8ff5a6dd64d68d55daa79a4145bbd9c","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_100mK.hdf5","date_created":"2020-12-02T10:46:23Z","relation":"main_file","access_level":"open_access","content_type":"application/octet-stream","file_size":167055},{"file_id":"8856","success":1,"date_updated":"2020-12-02T10:46:23Z","file_name":"dev2-jj2-ICvsVG-Tdependence_1100mK.hdf5","checksum":"f9309e1f1a5f727281960b01a3be64b4","creator":"gkatsaro","date_created":"2020-12-02T10:46:23Z","relation":"main_file","access_level":"open_access","content_type":"application/octet-stream","file_size":149648},{"access_level":"open_access","content_type":"application/octet-stream","file_size":144688,"creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_1200mK.hdf5","checksum":"e0589a34db4c5b7643c8179b0c156e48","date_created":"2020-12-02T10:46:23Z","relation":"main_file","date_updated":"2020-12-02T10:46:23Z","file_id":"8857","success":1},{"file_id":"8858","success":1,"date_updated":"2020-12-02T10:46:23Z","checksum":"f9736851466851cca596124b1ccdbe01","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_125mK.hdf5","date_created":"2020-12-02T10:46:23Z","relation":"main_file","access_level":"open_access","content_type":"application/octet-stream","file_size":148611},{"file_size":144702,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:23Z","file_name":"dev2-jj2-ICvsVG-Tdependence_1300mK.hdf5","checksum":"d517a4781bb242f7bfb75e7c054131e4","creator":"gkatsaro","date_updated":"2020-12-02T10:46:23Z","success":1,"file_id":"8859"},{"checksum":"ce1dafef1008405b7d63b9d9018bba0d","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_1400mK.hdf5","relation":"main_file","date_created":"2020-12-02T10:46:23Z","content_type":"application/octet-stream","access_level":"open_access","file_size":150639,"success":1,"file_id":"8860","date_updated":"2020-12-02T10:46:23Z"},{"date_updated":"2020-12-02T10:46:23Z","file_id":"8861","success":1,"file_size":150819,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:23Z","relation":"main_file","file_name":"dev2-jj2-ICvsVG-Tdependence_1500mK.hdf5","creator":"gkatsaro","checksum":"0a13039fdb83caee41437685fe73d2b4"},{"file_size":148362,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:24Z","creator":"gkatsaro","checksum":"6e543bc92d4dd4b9b2fcfd7992bfa101","file_name":"dev2-jj2-ICvsVG-Tdependence_150mK.hdf5","date_updated":"2020-12-02T10:46:24Z","file_id":"8862","success":1},{"date_updated":"2020-12-02T10:46:24Z","file_id":"8863","success":1,"access_level":"open_access","content_type":"application/octet-stream","file_size":150766,"file_name":"dev2-jj2-ICvsVG-Tdependence_1600mK.hdf5","checksum":"91cfcef1edfbb5c7bed3dde4b2cee5b8","creator":"gkatsaro","date_created":"2020-12-02T10:46:24Z","relation":"main_file"},{"file_id":"8864","success":1,"date_updated":"2020-12-02T10:46:24Z","date_created":"2020-12-02T10:46:24Z","relation":"main_file","checksum":"528fa8c3128e0d79de599ba0bc715665","file_name":"dev2-jj2-ICvsVG-Tdependence_1700mK.hdf5","creator":"gkatsaro","file_size":169554,"access_level":"open_access","content_type":"application/octet-stream"},{"date_updated":"2020-12-02T10:46:24Z","success":1,"file_id":"8865","file_size":148548,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:24Z","relation":"main_file","creator":"gkatsaro","checksum":"9e35c7f20c0b162e205bfa520dc4535d","file_name":"dev2-jj2-ICvsVG-Tdependence_175mK.hdf5"},{"access_level":"open_access","content_type":"application/octet-stream","file_size":147386,"file_name":"dev2-jj2-ICvsVG-Tdependence_1800mK.hdf5","checksum":"1fb5a8b651447a7204ae31883a1da269","creator":"gkatsaro","date_created":"2020-12-02T10:46:24Z","relation":"main_file","date_updated":"2020-12-02T10:46:24Z","success":1,"file_id":"8866"},{"content_type":"application/octet-stream","access_level":"open_access","file_size":147265,"creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_1900mK.hdf5","checksum":"0d3ee65697bceaae15fbcd5d5a8480c1","relation":"main_file","date_created":"2020-12-02T10:46:24Z","date_updated":"2020-12-02T10:46:24Z","success":1,"file_id":"8867"},{"file_size":147371,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:24Z","relation":"main_file","file_name":"dev2-jj2-ICvsVG-Tdependence_2000mK.hdf5","checksum":"fc386694414fee55a21adbc21c5c9b35","creator":"gkatsaro","date_updated":"2020-12-02T10:46:24Z","success":1,"file_id":"8868"},{"success":1,"file_id":"8869","date_updated":"2020-12-02T10:46:24Z","checksum":"de7c4a302b9fbad6dbcd7dd76af9f585","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_200mK.hdf5","date_created":"2020-12-02T10:46:24Z","relation":"main_file","access_level":"open_access","content_type":"application/octet-stream","file_size":148576},{"file_id":"8870","success":1,"date_updated":"2020-12-02T10:46:24Z","date_created":"2020-12-02T10:46:24Z","relation":"main_file","creator":"gkatsaro","checksum":"3f31eb2fb17cdaa70f4f3de2f1c6a563","file_name":"dev2-jj2-ICvsVG-Tdependence_20mK.hdf5","file_size":183004,"access_level":"open_access","content_type":"application/octet-stream"},{"file_id":"8871","success":1,"date_updated":"2020-12-02T10:46:24Z","file_name":"dev2-jj2-ICvsVG-Tdependence_2100mK.hdf5","checksum":"9044e65b660b5a90931ddcc0d4da7baa","creator":"gkatsaro","relation":"main_file","date_created":"2020-12-02T10:46:24Z","content_type":"application/octet-stream","access_level":"open_access","file_size":131582},{"success":1,"file_id":"8872","date_updated":"2020-12-02T10:46:24Z","relation":"main_file","date_created":"2020-12-02T10:46:24Z","checksum":"a4d0644bed0076a5c3a9b10dadac217a","file_name":"dev2-jj2-ICvsVG-Tdependence_2200mK.hdf5","creator":"gkatsaro","file_size":131645,"content_type":"application/octet-stream","access_level":"open_access"},{"date_updated":"2020-12-02T10:46:24Z","file_id":"8873","success":1,"content_type":"application/octet-stream","access_level":"open_access","file_size":144366,"file_name":"dev2-jj2-ICvsVG-Tdependence_225mK.hdf5","creator":"gkatsaro","checksum":"7177bd4d5bd80655b513168ebdf4a0c6","relation":"main_file","date_created":"2020-12-02T10:46:24Z"},{"file_id":"8874","success":1,"date_updated":"2020-12-02T10:46:24Z","creator":"gkatsaro","checksum":"62e51c2cabcb586af21222e60eb8910e","file_name":"dev2-jj2-ICvsVG-Tdependence_2300mK.hdf5","date_created":"2020-12-02T10:46:24Z","relation":"main_file","access_level":"open_access","content_type":"application/octet-stream","file_size":148466},{"success":1,"file_id":"8875","date_updated":"2020-12-02T10:46:25Z","checksum":"67f943fbaae90d117f0f82c3a29e6ccc","file_name":"dev2-jj2-ICvsVG-Tdependence_2400mK.hdf5","creator":"gkatsaro","date_created":"2020-12-02T10:46:25Z","relation":"main_file","access_level":"open_access","content_type":"application/octet-stream","file_size":160774},{"date_updated":"2020-12-02T10:46:25Z","file_id":"8876","success":1,"file_size":150110,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:25Z","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_2500mK.hdf5","checksum":"c6b33f7c61ba57178fa613c58131fd3d"},{"creator":"gkatsaro","checksum":"be127426947b8778cfae29a7ad2013f1","file_name":"dev2-jj2-ICvsVG-Tdependence_250mK.hdf5","relation":"main_file","date_created":"2020-12-02T10:46:25Z","content_type":"application/octet-stream","access_level":"open_access","file_size":144419,"file_id":"8877","success":1,"date_updated":"2020-12-02T10:46:25Z"},{"date_created":"2020-12-02T10:46:25Z","relation":"main_file","file_name":"dev2-jj2-ICvsVG-Tdependence_2600mK.hdf5","creator":"gkatsaro","checksum":"81dfeb4d94c1efec10b623e94d13faa5","file_size":148905,"access_level":"open_access","content_type":"application/octet-stream","success":1,"file_id":"8878","date_updated":"2020-12-02T10:46:25Z"},{"checksum":"5c0a37e0de317c7d8df62075ff35f1ec","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_2700mK.hdf5","date_created":"2020-12-02T10:46:25Z","relation":"main_file","access_level":"open_access","content_type":"application/octet-stream","file_size":131966,"file_id":"8879","success":1,"date_updated":"2020-12-02T10:46:25Z"},{"file_size":144253,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:25Z","checksum":"0f25d03f2551cbd903c7522883510492","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_275mK.hdf5","date_updated":"2020-12-02T10:46:25Z","file_id":"8880","success":1},{"relation":"main_file","date_created":"2020-12-02T10:46:25Z","checksum":"93923640d8bb599f6a459d2fda915b8b","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_2800mK.hdf5","file_size":131997,"content_type":"application/octet-stream","access_level":"open_access","file_id":"8881","success":1,"date_updated":"2020-12-02T10:46:25Z"},{"success":1,"file_id":"8882","date_updated":"2020-12-02T10:46:25Z","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_2900mK.hdf5","checksum":"c4fcf44e88ed344f4b747a67cae4e147","relation":"main_file","date_created":"2020-12-02T10:46:25Z","content_type":"application/octet-stream","access_level":"open_access","file_size":131950},{"file_size":150616,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:25Z","file_name":"dev2-jj2-ICvsVG-Tdependence_3000mK.hdf5","checksum":"5c1b296c6e654b16f610516b4a2fae30","creator":"gkatsaro","date_updated":"2020-12-02T10:46:25Z","success":1,"file_id":"8883"},{"file_id":"8884","success":1,"date_updated":"2020-12-02T10:46:25Z","relation":"main_file","date_created":"2020-12-02T10:46:25Z","file_name":"dev2-jj2-ICvsVG-Tdependence_300mK.hdf5","checksum":"5d1a2735216b1d6abf4c2645ebe0164e","creator":"gkatsaro","file_size":144570,"content_type":"application/octet-stream","access_level":"open_access"},{"checksum":"50dd9572cee3262ab4d64573289f9832","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_3100mK.hdf5","relation":"main_file","date_created":"2020-12-02T10:46:25Z","content_type":"application/octet-stream","access_level":"open_access","file_size":150709,"file_id":"8885","success":1,"date_updated":"2020-12-02T10:46:25Z"},{"checksum":"f528a1daeaddef5deef914798f5569ec","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_3200mK.hdf5","relation":"main_file","date_created":"2020-12-02T10:46:25Z","content_type":"application/octet-stream","access_level":"open_access","file_size":131954,"success":1,"file_id":"8886","date_updated":"2020-12-02T10:46:25Z"},{"file_size":144197,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:25Z","file_name":"dev2-jj2-ICvsVG-Tdependence_325mK.hdf5","checksum":"c2f53134c6877f200bdf4e5638e5c6d3","creator":"gkatsaro","date_updated":"2020-12-02T10:46:25Z","success":1,"file_id":"8887"},{"date_updated":"2020-12-02T10:46:25Z","file_id":"8888","success":1,"file_size":144729,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:25Z","relation":"main_file","file_name":"dev2-jj2-ICvsVG-Tdependence_360mK.hdf5","checksum":"10dd70f340df3bbe0cfe8cc9e6427d50","creator":"gkatsaro"},{"date_updated":"2020-12-02T10:46:26Z","file_id":"8889","success":1,"content_type":"application/octet-stream","access_level":"open_access","file_size":144502,"creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_400mK.hdf5","checksum":"6da19e1e3ff6f254ce859a2c6952fd3a","relation":"main_file","date_created":"2020-12-02T10:46:26Z"},{"file_size":144280,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:26Z","relation":"main_file","checksum":"49b78d23ef1538e1ecfc51dcfcf423d4","file_name":"dev2-jj2-ICvsVG-Tdependence_430mK.hdf5","creator":"gkatsaro","date_updated":"2020-12-02T10:46:26Z","file_id":"8890","success":1},{"date_created":"2020-12-02T10:46:26Z","relation":"main_file","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_45mK.hdf5","checksum":"065610415e2386a6e571fce3f14a2fc4","file_size":173158,"access_level":"open_access","content_type":"application/octet-stream","file_id":"8891","success":1,"date_updated":"2020-12-02T10:46:26Z"},{"content_type":"application/octet-stream","access_level":"open_access","file_size":144447,"file_name":"dev2-jj2-ICvsVG-Tdependence_460mK.hdf5","creator":"gkatsaro","checksum":"06a83873a1e72377728c080fb8db15fd","relation":"main_file","date_created":"2020-12-02T10:46:26Z","date_updated":"2020-12-02T10:46:26Z","file_id":"8892","success":1},{"date_updated":"2020-12-02T10:46:26Z","file_id":"8893","success":1,"file_size":144800,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:26Z","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_500mK.hdf5","checksum":"c4391fda28b9a44e44f2d039ec8651b7"},{"content_type":"application/octet-stream","access_level":"open_access","file_size":144594,"creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_530mK.hdf5","checksum":"e9d2ffde84357e8e0be5581408da9b8a","relation":"main_file","date_created":"2020-12-02T10:46:26Z","date_updated":"2020-12-02T10:46:26Z","success":1,"file_id":"8894"},{"file_size":144681,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:26Z","file_name":"dev2-jj2-ICvsVG-Tdependence_560mK.hdf5","creator":"gkatsaro","checksum":"d2966be14e8877ca27bf5daff23d76d6","date_updated":"2020-12-02T10:46:26Z","file_id":"8895","success":1},{"date_updated":"2020-12-02T10:46:26Z","success":1,"file_id":"8896","file_size":144909,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:26Z","relation":"main_file","creator":"gkatsaro","checksum":"75cc9b9a2991b356471ca956076cc376","file_name":"dev2-jj2-ICvsVG-Tdependence_600mK.hdf5"},{"file_id":"8897","success":1,"date_updated":"2020-12-02T10:46:26Z","relation":"main_file","date_created":"2020-12-02T10:46:26Z","checksum":"9144cff758563b93f22c7946146fa5d5","file_name":"dev2-jj2-ICvsVG-Tdependence_630mK.hdf5","creator":"gkatsaro","file_size":144985,"content_type":"application/octet-stream","access_level":"open_access"},{"date_updated":"2020-12-02T10:46:26Z","success":1,"file_id":"8898","content_type":"application/octet-stream","access_level":"open_access","file_size":144782,"creator":"gkatsaro","checksum":"14509a2dd1bf74d9c6fc05c046e5b6ff","file_name":"dev2-jj2-ICvsVG-Tdependence_660mK.hdf5","relation":"main_file","date_created":"2020-12-02T10:46:26Z"},{"content_type":"application/octet-stream","access_level":"open_access","file_size":145046,"checksum":"9c38e2178f0fda99a02e6d7b2c034082","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_700mK.hdf5","relation":"main_file","date_created":"2020-12-02T10:46:26Z","date_updated":"2020-12-02T10:46:26Z","file_id":"8899","success":1},{"date_created":"2020-12-02T10:46:26Z","relation":"main_file","checksum":"962a205f7ff515b9aad2df28cc5a95e7","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_730mK.hdf5","file_size":145107,"access_level":"open_access","content_type":"application/octet-stream","success":1,"file_id":"8900","date_updated":"2020-12-02T10:46:26Z"},{"success":1,"file_id":"8901","date_updated":"2020-12-02T10:46:26Z","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_760mK.hdf5","checksum":"5e24b1a7840e6a2b3b04bf922b521ec4","date_created":"2020-12-02T10:46:26Z","relation":"main_file","access_level":"open_access","content_type":"application/octet-stream","file_size":145018},{"file_size":145318,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:27Z","relation":"main_file","file_name":"dev2-jj2-ICvsVG-Tdependence_800mK.hdf5","creator":"gkatsaro","checksum":"dfbefc2d53df7afd1e534ced7d669b30","date_updated":"2020-12-02T10:46:27Z","file_id":"8902","success":1},{"file_size":145322,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:27Z","checksum":"1629ae97d2748bbf02fdb2d165d236e5","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_830mK.hdf5","date_updated":"2020-12-02T10:46:27Z","success":1,"file_id":"8903"},{"date_updated":"2020-12-02T10:46:27Z","file_id":"8904","success":1,"file_size":145282,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2020-12-02T10:46:27Z","relation":"main_file","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_850mK.hdf5","checksum":"618f507780343c6b9145c40d3d5b0ff0"},{"relation":"main_file","date_created":"2020-12-02T10:46:27Z","file_name":"dev2-jj2-ICvsVG-Tdependence_900mK.hdf5","creator":"gkatsaro","checksum":"7547c3607280c7eedca3168854976cc9","file_size":143681,"content_type":"application/octet-stream","access_level":"open_access","success":1,"file_id":"8905","date_updated":"2020-12-02T10:46:27Z"},{"date_updated":"2020-12-02T10:46:27Z","file_id":"8906","success":1,"access_level":"open_access","content_type":"application/octet-stream","file_size":167184,"creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_90mK.hdf5","checksum":"514d9a43ed3888ce7d8b26ca772cadc3","date_created":"2020-12-02T10:46:27Z","relation":"main_file"},{"date_created":"2020-12-02T10:46:27Z","relation":"main_file","checksum":"77285471178fa68c1eade48761b2aba5","file_name":"dev2-jj2-ICvsVG-Tdependence_930mK.hdf5","creator":"gkatsaro","file_size":143491,"access_level":"open_access","content_type":"application/octet-stream","file_id":"8907","success":1,"date_updated":"2020-12-02T10:46:27Z"},{"date_updated":"2020-12-02T10:46:27Z","file_id":"8908","success":1,"file_size":144057,"content_type":"application/octet-stream","access_level":"open_access","relation":"main_file","date_created":"2020-12-02T10:46:27Z","checksum":"bf8da09fcfa20196fb7e65528a581297","creator":"gkatsaro","file_name":"dev2-jj2-ICvsVG-Tdependence_965mK.hdf5"}],"year":"2020","article_processing_charge":"No","tmp":{"short":"CC0 (1.0)","name":"Creative Commons Public Domain Dedication (CC0 1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","image":"/images/cc_0.png"},"citation":{"ieee":"G. Katsaros, “Enhancement of proximity induced superconductivity in planar Germanium.” Institute of Science and Technology Austria, 2020.","mla":"Katsaros, Georgios. <i>Enhancement of Proximity Induced Superconductivity in Planar Germanium</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8834\">10.15479/AT:ISTA:8834</a>.","ista":"Katsaros G. 2020. Enhancement of proximity induced superconductivity in planar Germanium, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:8834\">10.15479/AT:ISTA:8834</a>.","ama":"Katsaros G. Enhancement of proximity induced superconductivity in planar Germanium. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8834\">10.15479/AT:ISTA:8834</a>","apa":"Katsaros, G. (2020). Enhancement of proximity induced superconductivity in planar Germanium. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8834\">https://doi.org/10.15479/AT:ISTA:8834</a>","chicago":"Katsaros, Georgios. “Enhancement of Proximity Induced Superconductivity in Planar Germanium.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8834\">https://doi.org/10.15479/AT:ISTA:8834</a>.","short":"G. Katsaros, (2020)."},"doi":"10.15479/AT:ISTA:8834","publisher":"Institute of Science and Technology Austria","abstract":[{"text":"This data collection contains the transport data for figures presented in the supplementary material of \"Enhancement of Proximity Induced Superconductivity in Planar Germanium\" by K. Aggarwal, et. al. \r\nThe measurements were done using Labber Software and the data is stored in the hdf5 file format. The files can be opened using either the Labber Log Browser (https://labber.org/overview/) or Labber Python API (http://labber.org/online-doc/api/LogFile.html).\r\n","lang":"eng"}],"has_accepted_license":"1","date_created":"2020-12-02T10:49:30Z","department":[{"_id":"GeKa"}],"corr_author":"1","status":"public","oa_version":"Published Version","ddc":["530"],"month":"12","_id":"8834"},{"page":"81-95","oa":1,"isi":1,"type":"journal_article","file":[{"date_updated":"2020-12-03T11:45:26Z","success":1,"file_id":"8915","access_level":"open_access","content_type":"application/pdf","file_size":4071247,"creator":"dernst","checksum":"da7413c819e079720669c82451b49294","file_name":"2020_Neuroscience_Salamatina.pdf","date_created":"2020-12-03T11:45:26Z","relation":"main_file"}],"article_processing_charge":"Yes (via OA deal)","year":"2020","publication_status":"published","date_published":"2020-12-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Elsevier","has_accepted_license":"1","abstract":[{"text":"Amyotrophic lateral sclerosis (ALS) leads to a loss of specific motor neuron populations in the spinal cord and cortex. Emerging evidence suggests that interneurons may also be affected, but a detailed characterization of interneuron loss and its potential impacts on motor neuron loss and disease progression is lacking. To examine this issue, the fate of V1 inhibitory neurons during ALS was assessed in the ventral spinal cord using the SODG93A mouse model. The V1 population makes up ∼30% of all ventral inhibitory neurons, ∼50% of direct inhibitory synaptic contacts onto motor neuron cell bodies, and is thought to play a key role in modulating motor output, in part through recurrent and reciprocal inhibitory circuits. We find that approximately half of V1 inhibitory neurons are lost in SODG93A mice at late disease stages, but that this loss is delayed relative to the loss of motor neurons and V2a excitatory neurons. We further identify V1 subpopulations based on transcription factor expression that are differentially susceptible to degeneration in SODG93A mice. At an early disease stage, we show that V1 synaptic contacts with motor neuron cell bodies increase, suggesting an upregulation of inhibition before V1 neurons are lost in substantial numbers. These data support a model in which progressive changes in V1 synaptic contacts early in disease, and in select V1 subpopulations at later stages, represent a compensatory upregulation and then deleterious breakdown of specific interneuron circuits within the spinal cord.","lang":"eng"}],"date_created":"2020-12-03T11:47:31Z","pmid":1,"intvolume":"       450","language":[{"iso":"eng"}],"status":"public","corr_author":"1","month":"12","publication":"Neuroscience","ddc":["570"],"article_type":"original","publication_identifier":{"issn":["0306-4522"]},"acknowledgement":"This work was made possible by the generous support of Project ALS. Imaging and related analyses were facilitated by The Waitt Advanced Biophotonics Center Core at the Salk Institute, supported by grants from NIH-NCI CCSG (P30 014195) and NINDS Neuroscience Center (NS072031). The authors would like to additionally thank Drs. Jane Dodd, Robert Brownstone, and Laskaro Zagoraiou for helpful comments on the manuscript. This manuscript is dedicated to Tom Jessell, an inspirational scientist, friend and mentor.","file_date_updated":"2020-12-03T11:45:26Z","day":"01","external_id":{"pmid":["32858144"],"isi":["000595588700008"]},"author":[{"full_name":"Salamatina, Alina","first_name":"Alina","last_name":"Salamatina"},{"first_name":"Jerry H","last_name":"Yang","full_name":"Yang, Jerry H"},{"full_name":"Brenner-Morton, Susan","last_name":"Brenner-Morton","first_name":"Susan"},{"last_name":"Bikoff","first_name":"Jay B ","full_name":"Bikoff, Jay B "},{"first_name":"Linjing","last_name":"Fang","full_name":"Fang, Linjing"},{"last_name":"Kintner","first_name":"Christopher R","full_name":"Kintner, Christopher R"},{"first_name":"Thomas M","last_name":"Jessell","full_name":"Jessell, Thomas M"},{"first_name":"Lora Beatrice Jaeger","last_name":"Sweeney","orcid":"0000-0001-9242-5601","full_name":"Sweeney, Lora Beatrice Jaeger","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425"}],"date_updated":"2024-10-09T21:00:14Z","title":"Differential loss of spinal interneurons in a mouse model of ALS","volume":450,"scopus_import":"1","department":[{"_id":"LoSw"}],"tmp":{"image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"doi":"10.1016/j.neuroscience.2020.08.011","citation":{"short":"A. Salamatina, J.H. Yang, S. Brenner-Morton, J.B. Bikoff, L. Fang, C.R. Kintner, T.M. Jessell, L.B. Sweeney, Neuroscience 450 (2020) 81–95.","chicago":"Salamatina, Alina, Jerry H Yang, Susan Brenner-Morton, Jay B  Bikoff, Linjing Fang, Christopher R Kintner, Thomas M Jessell, and Lora B. Sweeney. “Differential Loss of Spinal Interneurons in a Mouse Model of ALS.” <i>Neuroscience</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.neuroscience.2020.08.011\">https://doi.org/10.1016/j.neuroscience.2020.08.011</a>.","ista":"Salamatina A, Yang JH, Brenner-Morton S, Bikoff JB, Fang L, Kintner CR, Jessell TM, Sweeney LB. 2020. Differential loss of spinal interneurons in a mouse model of ALS. Neuroscience. 450, 81–95.","ama":"Salamatina A, Yang JH, Brenner-Morton S, et al. Differential loss of spinal interneurons in a mouse model of ALS. <i>Neuroscience</i>. 2020;450:81-95. doi:<a href=\"https://doi.org/10.1016/j.neuroscience.2020.08.011\">10.1016/j.neuroscience.2020.08.011</a>","apa":"Salamatina, A., Yang, J. H., Brenner-Morton, S., Bikoff, J. B., Fang, L., Kintner, C. R., … Sweeney, L. B. (2020). Differential loss of spinal interneurons in a mouse model of ALS. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuroscience.2020.08.011\">https://doi.org/10.1016/j.neuroscience.2020.08.011</a>","ieee":"A. Salamatina <i>et al.</i>, “Differential loss of spinal interneurons in a mouse model of ALS,” <i>Neuroscience</i>, vol. 450. Elsevier, pp. 81–95, 2020.","mla":"Salamatina, Alina, et al. “Differential Loss of Spinal Interneurons in a Mouse Model of ALS.” <i>Neuroscience</i>, vol. 450, Elsevier, 2020, pp. 81–95, doi:<a href=\"https://doi.org/10.1016/j.neuroscience.2020.08.011\">10.1016/j.neuroscience.2020.08.011</a>."},"quality_controlled":"1","oa_version":"Published Version","_id":"8914"},{"intvolume":"        11","language":[{"iso":"eng"}],"publisher":"Frontiers","pmid":1,"has_accepted_license":"1","date_created":"2020-12-06T23:01:14Z","abstract":[{"lang":"eng","text":"Maintaining fertility in a fluctuating environment is key to the reproductive success of flowering plants. Meiosis and pollen formation are particularly sensitive to changes in growing conditions, especially temperature. We have previously identified cyclin-dependent kinase G1 (CDKG1) as a master regulator of temperature-dependent meiosis and this may involve the regulation of alternative splicing (AS), including of its own transcript. CDKG1 mRNA can undergo several AS events, potentially producing two protein variants: CDKG1L and CDKG1S, differing in their N-terminal domain which may be involved in co-factor interaction. In leaves, both isoforms have distinct temperature-dependent functions on target mRNA processing, but their role in pollen development is unknown. In the present study, we characterize the role of CDKG1L and CDKG1S in maintaining Arabidopsis fertility. We show that the long (L) form is necessary and sufficient to rescue the fertility defects of the cdkg1-1 mutant, while the short (S) form is unable to rescue fertility. On the other hand, an extra copy of CDKG1L reduces fertility. In addition, mutation of the ATP binding pocket of the kinase indicates that kinase activity is necessary for the function of CDKG1. Kinase mutants of CDKG1L and CDKG1S correctly localize to the cell nucleus and nucleus and cytoplasm, respectively, but are unable to rescue either the fertility or the splicing defects of the cdkg1-1 mutant. Furthermore, we show that there is partial functional overlap between CDKG1 and its paralog CDKG2 that could in part be explained by overlapping gene expression."}],"ddc":["580"],"month":"11","publication":"Frontiers in Plant Science","status":"public","oa":1,"type":"journal_article","isi":1,"date_published":"2020-11-10T00:00:00Z","article_number":"586870","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"file_size":1833244,"access_level":"open_access","content_type":"application/pdf","date_created":"2020-12-09T09:14:19Z","relation":"main_file","file_name":"2020_Frontiers_Nibau.pdf","creator":"dernst","checksum":"1c0ee6ce9950aa665d6a5cc64aa6b752","date_updated":"2020-12-09T09:14:19Z","success":1,"file_id":"8929"}],"publication_status":"published","article_processing_charge":"No","year":"2020","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.3389/fpls.2020.586870","citation":{"chicago":"Nibau, Candida, Despoina Dadarou, Nestoras Kargios, Areti Mallioura, Narcis Fernandez-Fuentes, Nicola Cavallari, and John H. Doonan. “A Functional Kinase Is Necessary for Cyclin-Dependent Kinase G1 (CDKG1) to Maintain Fertility at High Ambient Temperature in Arabidopsis.” <i>Frontiers in Plant Science</i>. Frontiers, 2020. <a href=\"https://doi.org/10.3389/fpls.2020.586870\">https://doi.org/10.3389/fpls.2020.586870</a>.","short":"C. Nibau, D. Dadarou, N. Kargios, A. Mallioura, N. Fernandez-Fuentes, N. Cavallari, J.H. Doonan, Frontiers in Plant Science 11 (2020).","mla":"Nibau, Candida, et al. “A Functional Kinase Is Necessary for Cyclin-Dependent Kinase G1 (CDKG1) to Maintain Fertility at High Ambient Temperature in Arabidopsis.” <i>Frontiers in Plant Science</i>, vol. 11, 586870, Frontiers, 2020, doi:<a href=\"https://doi.org/10.3389/fpls.2020.586870\">10.3389/fpls.2020.586870</a>.","ieee":"C. Nibau <i>et al.</i>, “A functional kinase is necessary for cyclin-dependent kinase G1 (CDKG1) to maintain fertility at high ambient temperature in Arabidopsis,” <i>Frontiers in Plant Science</i>, vol. 11. Frontiers, 2020.","ista":"Nibau C, Dadarou D, Kargios N, Mallioura A, Fernandez-Fuentes N, Cavallari N, Doonan JH. 2020. A functional kinase is necessary for cyclin-dependent kinase G1 (CDKG1) to maintain fertility at high ambient temperature in Arabidopsis. Frontiers in Plant Science. 11, 586870.","ama":"Nibau C, Dadarou D, Kargios N, et al. A functional kinase is necessary for cyclin-dependent kinase G1 (CDKG1) to maintain fertility at high ambient temperature in Arabidopsis. <i>Frontiers in Plant Science</i>. 2020;11. doi:<a href=\"https://doi.org/10.3389/fpls.2020.586870\">10.3389/fpls.2020.586870</a>","apa":"Nibau, C., Dadarou, D., Kargios, N., Mallioura, A., Fernandez-Fuentes, N., Cavallari, N., &#38; Doonan, J. H. (2020). A functional kinase is necessary for cyclin-dependent kinase G1 (CDKG1) to maintain fertility at high ambient temperature in Arabidopsis. <i>Frontiers in Plant Science</i>. Frontiers. <a href=\"https://doi.org/10.3389/fpls.2020.586870\">https://doi.org/10.3389/fpls.2020.586870</a>"},"volume":11,"scopus_import":"1","department":[{"_id":"EvBe"}],"quality_controlled":"1","oa_version":"Published Version","_id":"8924","external_id":{"isi":["000591637000001"],"pmid":["33240303"]},"day":"10","file_date_updated":"2020-12-09T09:14:19Z","publication_identifier":{"eissn":["1664-462X"]},"acknowledgement":"CN, DD, NF-F, and JD were funded by the BBSRC (grant number BB/M009459/1). NK and AM were funded through the ERASMUS+Program. NC was funded by the VIPS Program of the Austrian Federal Ministry of Science and Research and the City of Vienna.","article_type":"original","title":"A functional kinase is necessary for cyclin-dependent kinase G1 (CDKG1) to maintain fertility at high ambient temperature in Arabidopsis","date_updated":"2025-06-12T07:02:22Z","author":[{"full_name":"Nibau, Candida","first_name":"Candida","last_name":"Nibau"},{"last_name":"Dadarou","first_name":"Despoina","full_name":"Dadarou, Despoina"},{"full_name":"Kargios, Nestoras","last_name":"Kargios","first_name":"Nestoras"},{"first_name":"Areti","last_name":"Mallioura","full_name":"Mallioura, Areti"},{"full_name":"Fernandez-Fuentes, Narcis","last_name":"Fernandez-Fuentes","first_name":"Narcis"},{"first_name":"Nicola","last_name":"Cavallari","full_name":"Cavallari, Nicola","id":"457160E6-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Doonan","first_name":"John H.","full_name":"Doonan, John H."}]},{"volume":10,"department":[{"_id":"MaIb"}],"scopus_import":"1","doi":"10.1021/acscatal.0c03210","citation":{"short":"E. Irtem, D. Arenas Esteban, M. Duarte, D. Choukroun, S. Lee, M. Ibáñez, S. Bals, T. Breugelmans, ACS Catalysis 10 (2020) 13468–13478.","chicago":"Irtem, Erdem, Daniel Arenas Esteban, Miguel Duarte, Daniel Choukroun, Seungho Lee, Maria Ibáñez, Sara Bals, and Tom Breugelmans. “Ligand-Mode Directed Selectivity in Cu-Ag Core-Shell Based Gas Diffusion Electrodes for CO2 Electroreduction.” <i>ACS Catalysis</i>. American Chemical Society, 2020. <a href=\"https://doi.org/10.1021/acscatal.0c03210\">https://doi.org/10.1021/acscatal.0c03210</a>.","apa":"Irtem, E., Arenas Esteban, D., Duarte, M., Choukroun, D., Lee, S., Ibáñez, M., … Breugelmans, T. (2020). Ligand-mode directed selectivity in Cu-Ag core-shell based gas diffusion electrodes for CO2 electroreduction. <i>ACS Catalysis</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acscatal.0c03210\">https://doi.org/10.1021/acscatal.0c03210</a>","ista":"Irtem E, Arenas Esteban D, Duarte M, Choukroun D, Lee S, Ibáñez M, Bals S, Breugelmans T. 2020. Ligand-mode directed selectivity in Cu-Ag core-shell based gas diffusion electrodes for CO2 electroreduction. ACS Catalysis. 10(22), 13468–13478.","ama":"Irtem E, Arenas Esteban D, Duarte M, et al. Ligand-mode directed selectivity in Cu-Ag core-shell based gas diffusion electrodes for CO2 electroreduction. <i>ACS Catalysis</i>. 2020;10(22):13468-13478. doi:<a href=\"https://doi.org/10.1021/acscatal.0c03210\">10.1021/acscatal.0c03210</a>","mla":"Irtem, Erdem, et al. “Ligand-Mode Directed Selectivity in Cu-Ag Core-Shell Based Gas Diffusion Electrodes for CO2 Electroreduction.” <i>ACS Catalysis</i>, vol. 10, no. 22, American Chemical Society, 2020, pp. 13468–78, doi:<a href=\"https://doi.org/10.1021/acscatal.0c03210\">10.1021/acscatal.0c03210</a>.","ieee":"E. Irtem <i>et al.</i>, “Ligand-mode directed selectivity in Cu-Ag core-shell based gas diffusion electrodes for CO2 electroreduction,” <i>ACS Catalysis</i>, vol. 10, no. 22. American Chemical Society, pp. 13468–13478, 2020."},"project":[{"call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","grant_number":"665385"}],"oa_version":"Submitted Version","quality_controlled":"1","main_file_link":[{"url":"https://repository.uantwerpen.be/docman/irua/190103/173803.pdf","open_access":"1"}],"_id":"8926","day":"20","acknowledgement":"The authors also acknowledge financial support from the University Research Fund (BOF-GOA-PS ID No. 33928). S.L. has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 665385.","publication_identifier":{"eissn":["2155-5435"]},"article_type":"original","external_id":{"isi":["000592978900031"]},"OA_place":"repository","author":[{"full_name":"Irtem, Erdem","first_name":"Erdem","last_name":"Irtem"},{"full_name":"Arenas Esteban, Daniel","last_name":"Arenas Esteban","first_name":"Daniel"},{"first_name":"Miguel","last_name":"Duarte","full_name":"Duarte, Miguel"},{"last_name":"Choukroun","first_name":"Daniel","full_name":"Choukroun, Daniel"},{"full_name":"Lee, Seungho","id":"BB243B88-D767-11E9-B658-BC13E6697425","first_name":"Seungho","last_name":"Lee","orcid":"0000-0002-6962-8598"},{"full_name":"Ibáñez, Maria","id":"43C61214-F248-11E8-B48F-1D18A9856A87","first_name":"Maria","last_name":"Ibáñez","orcid":"0000-0001-5013-2843"},{"last_name":"Bals","first_name":"Sara","full_name":"Bals, Sara"},{"first_name":"Tom","last_name":"Breugelmans","full_name":"Breugelmans, Tom"}],"title":"Ligand-mode directed selectivity in Cu-Ag core-shell based gas diffusion electrodes for CO2 electroreduction","date_updated":"2026-04-03T09:31:02Z","publisher":"American Chemical Society","date_created":"2020-12-06T23:01:15Z","abstract":[{"lang":"eng","text":"Bimetallic nanoparticles with tailored size and specific composition have shown promise as stable and selective catalysts for electrochemical reduction of CO2 (CO2R) in batch systems. Yet, limited effort was devoted to understand the effect of ligand coverage and postsynthesis treatments on CO2 reduction, especially under industrially applicable conditions, such as at high currents (>100 mA/cm2) using gas diffusion electrodes (GDE) and flow reactors. In this work, Cu–Ag core–shell nanoparticles (11 ± 2 nm) were prepared with three different surface modes: (i) capped with oleylamine, (ii) capped with monoisopropylamine, and (iii) surfactant-free with a reducing borohydride agent; Cu–Ag (OAm), Cu–Ag (MIPA), and Cu–Ag (NaBH4), respectively. The ligand exchange and removal was evidenced by infrared spectroscopy (ATR-FTIR) analysis, whereas high-resolution scanning transmission electron microscopy (HAADF-STEM) showed their effect on the interparticle distance and nanoparticle rearrangement. Later on, we developed a process-on-substrate method to track these effects on CO2R. Cu–Ag (OAm) gave a lower on-set potential for hydrocarbon production, whereas Cu–Ag (MIPA) and Cu–Ag (NaBH4) promoted syngas production. The electrochemical impedance and surface area analysis on the well-controlled electrodes showed gradual increases in the electrical conductivity and active surface area after each surface treatment. We found that the increasing amount of the triple phase boundaries (the meeting point for the electron–electrolyte–CO2 reactant) affect the required electrode potential and eventually the C+2e̅/C2e̅ product ratio. This study highlights the importance of the electron transfer to those active sites affected by the capping agents—particularly on larger substrates that are crucial for their industrial application."}],"intvolume":"        10","OA_type":"green","language":[{"iso":"eng"}],"issue":"22","publication":"ACS Catalysis","status":"public","month":"11","page":"13468-13478","oa":1,"type":"journal_article","isi":1,"ec_funded":1,"publication_status":"published","year":"2020","article_processing_charge":"No","date_published":"2020-11-20T00:00:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd"},{"publisher":"Institute of Science and Technology Austria","department":[{"_id":"GaTk"}],"date_created":"2020-12-09T15:04:02Z","has_accepted_license":"1","abstract":[{"text":"Phenomenological relations such as Ohm’s or Fourier’s law have a venerable history in physics but are still scarce in biology. This situation restrains predictive theory. Here, we build on bacterial “growth laws,” which capture physiological feedback between translation and cell growth, to construct a minimal biophysical model for the combined action of ribosome-targeting antibiotics. Our model predicts drug interactions like antagonism or synergy solely from responses to individual drugs. We provide analytical results for limiting cases, which agree well with numerical results. We systematically refine the model by including direct physical interactions of different antibiotics on the ribosome. In a limiting case, our model provides a mechanistic underpinning for recent predictions of higher-order interactions that were derived using entropy maximization. We further refine the model to include the effects of antibiotics that mimic starvation and the presence of resistance genes. We describe the impact of a starvation-mimicking antibiotic on drug interactions analytically and verify it experimentally. Our extended model suggests a change in the type of drug interaction that depends on the strength of resistance, which challenges established rescaling paradigms. We experimentally show that the presence of unregulated resistance genes can lead to altered drug interaction, which agrees with the prediction of the model. While minimal, the model is readily adaptable and opens the door to predicting interactions of second and higher-order in a broad range of biological systems.","lang":"eng"}],"doi":"10.15479/AT:ISTA:8930","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"citation":{"mla":"Kavcic, Bor. <i>Analysis Scripts and Research Data for the Paper “Minimal Biophysical Model of Combined Antibiotic Action.”</i> Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8930\">10.15479/AT:ISTA:8930</a>.","ieee":"B. Kavcic, “Analysis scripts and research data for the paper ‘Minimal biophysical model of combined antibiotic action.’” Institute of Science and Technology Austria, 2020.","ama":"Kavcic B. Analysis scripts and research data for the paper “Minimal biophysical model of combined antibiotic action.” 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8930\">10.15479/AT:ISTA:8930</a>","apa":"Kavcic, B. (2020). Analysis scripts and research data for the paper “Minimal biophysical model of combined antibiotic action.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8930\">https://doi.org/10.15479/AT:ISTA:8930</a>","ista":"Kavcic B. 2020. Analysis scripts and research data for the paper ‘Minimal biophysical model of combined antibiotic action’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:8930\">10.15479/AT:ISTA:8930</a>.","chicago":"Kavcic, Bor. “Analysis Scripts and Research Data for the Paper ‘Minimal Biophysical Model of Combined Antibiotic Action.’” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8930\">https://doi.org/10.15479/AT:ISTA:8930</a>.","short":"B. Kavcic, (2020)."},"oa_version":"Published Version","month":"12","status":"public","corr_author":"1","ddc":["570"],"_id":"8930","day":"10","file_date_updated":"2020-12-09T15:00:19Z","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"8997"}]},"oa":1,"type":"research_data","contributor":[{"id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","contributor_type":"supervisor","first_name":"Gašper","last_name":"Tkačik","orcid":"0000-0002-6699-1455"},{"id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","contributor_type":"supervisor","first_name":"Tobias","last_name":"Bollenbach"}],"author":[{"full_name":"Kavcic, Bor","id":"350F91D2-F248-11E8-B48F-1D18A9856A87","first_name":"Bor","last_name":"Kavcic","orcid":"0000-0001-6041-254X"}],"file":[{"date_created":"2020-12-09T15:00:19Z","relation":"main_file","file_name":"PLoSCompBiol2020_datarep.zip","checksum":"60a818edeffaa7da1ebf5f8fbea9ba18","creator":"bkavcic","file_size":315494370,"access_level":"open_access","content_type":"application/zip","success":1,"file_id":"8932","date_updated":"2020-12-09T15:00:19Z"}],"year":"2020","keyword":["Escherichia coli","antibiotic combinations","translation","growth laws","drug interactions","bacterial physiology","translation inhibitors"],"article_processing_charge":"No","title":"Analysis scripts and research data for the paper \"Minimal biophysical model of combined antibiotic action\"","date_updated":"2025-06-12T06:33:18Z","date_published":"2020-12-10T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"file":[{"access_level":"open_access","content_type":"application/pdf","file_size":8056434,"file_name":"2020_CellReports_Tan.pdf","creator":"dernst","checksum":"ed18cba0fb48ed2e789381a54cc21904","date_created":"2020-12-14T07:33:39Z","relation":"main_file","date_updated":"2020-12-14T07:33:39Z","success":1,"file_id":"8948"}],"article_processing_charge":"Yes","year":"2020","publication_status":"published","article_number":"108463","date_published":"2020-12-01T00:00:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"isi":1,"ec_funded":1,"type":"journal_article","issue":"9","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"status":"public","ddc":["580"],"month":"12","corr_author":"1","publication":"Cell Reports","publisher":"Elsevier","has_accepted_license":"1","abstract":[{"lang":"eng","text":"The widely used non-steroidal anti-inflammatory drugs (NSAIDs) are derivatives of the phytohormone salicylic acid (SA). SA is well known to regulate plant immunity and development, whereas there have been few reports focusing on the effects of NSAIDs in plants. Our studies here reveal that NSAIDs exhibit largely overlapping physiological activities to SA in the model plant Arabidopsis. NSAID treatments lead to shorter and agravitropic primary roots and inhibited lateral root organogenesis. Notably, in addition to the SA-like action, which in roots involves binding to the protein phosphatase 2A (PP2A), NSAIDs also exhibit PP2A-independent effects. Cell biological and biochemical analyses reveal that many NSAIDs bind directly to and inhibit the chaperone activity of TWISTED DWARF1, thereby regulating actin cytoskeleton dynamics and subsequent endosomal trafficking. Our findings uncover an unexpected bioactivity of human pharmaceuticals in plants and provide insights into the molecular mechanism underlying the cellular action of this class of anti-inflammatory compounds."}],"date_created":"2020-12-13T23:01:21Z","pmid":1,"intvolume":"        33","language":[{"iso":"eng"}],"author":[{"id":"2DE75584-F248-11E8-B48F-1D18A9856A87","full_name":"Tan, Shutang","orcid":"0000-0002-0471-8285","last_name":"Tan","first_name":"Shutang"},{"first_name":"Martin","last_name":"Di Donato","full_name":"Di Donato, Martin"},{"first_name":"Matous","orcid":"0000-0003-0619-7783","last_name":"Glanc","id":"1AE1EA24-02D0-11E9-9BAA-DAF4881429F2","full_name":"Glanc, Matous"},{"id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A","full_name":"Zhang, Xixi","first_name":"Xixi","orcid":"0000-0001-7048-4627","last_name":"Zhang"},{"first_name":"Petr","last_name":"Klíma","full_name":"Klíma, Petr"},{"full_name":"Liu, Jie","last_name":"Liu","first_name":"Jie"},{"last_name":"Bailly","first_name":"Aurélien","full_name":"Bailly, Aurélien"},{"last_name":"Ferro","first_name":"Noel","full_name":"Ferro, Noel"},{"first_name":"Jan","last_name":"Petrášek","full_name":"Petrášek, Jan"},{"full_name":"Geisler, Markus","last_name":"Geisler","first_name":"Markus"},{"full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jiří"}],"date_updated":"2026-04-03T09:30:47Z","title":"Non-steroidal anti-inflammatory drugs target TWISTED DWARF1-regulated actin dynamics and auxin transport-mediated plant development","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/plants-on-aspirin/","description":"News on IST Homepage"}]},"publication_identifier":{"eissn":["2211-1247"]},"acknowledgement":"We thank Drs. Sebastian Bednarek (University of Wisconsin-Madison), Niko Geldner (University of Lausanne), and Karin Schumacher (Heidelberg University) for kindly sharing published Arabidopsis lines; Dr. Satoshi Naramoto for the pPIN2::PIN2-GFP; pVHA-a1::VHA-a1-mRFP reporter; the staff at the Life Science Facility and Bioimaging Facility, Monika Hrtyan, and Dorota Jaworska at IST Austria for technical support; and Drs. Su Tang (Texas A&M University),\r\nMelinda Abas (BOKU), Eva Benkova´ (IST Austria), Christian Luschnig (BOKU), Bartel Vanholme (Gent University), and the Friml group for valuable discussions. The research leading to these findings was funded by the European Union’s Horizon 2020 program (ERC grant agreement no. 742985, to J.F.), the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no.\r\n291734, the Swiss National Funds (31003A_165877, to M.G.), the Ministry of Education, Youth, and Sports of the Czech Republic (project no. CZ.02.1.01/0.0/0.0/16_019/0000738, EU Operational Programme ‘‘Research, development and education and Centre for Plant Experimental Biology’’), and the EU Operational Programme Prague - Competitiveness (project no. CZ.2.16/3.1.00/21519). S.T. was funded by a European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship (ALTF 723-2015). X.Z. was partly supported by a PhD scholarship from the China Scholarship Council.","file_date_updated":"2020-12-14T07:33:39Z","article_type":"original","day":"01","external_id":{"pmid":["33264621"],"isi":["000595658100018"]},"oa_version":"Published Version","quality_controlled":"1","_id":"8943","volume":33,"department":[{"_id":"JiFr"}],"scopus_import":"1","doi":"10.1016/j.celrep.2020.108463","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"citation":{"mla":"Tan, Shutang, et al. “Non-Steroidal Anti-Inflammatory Drugs Target TWISTED DWARF1-Regulated Actin Dynamics and Auxin Transport-Mediated Plant Development.” <i>Cell Reports</i>, vol. 33, no. 9, 108463, Elsevier, 2020, doi:<a href=\"https://doi.org/10.1016/j.celrep.2020.108463\">10.1016/j.celrep.2020.108463</a>.","ieee":"S. Tan <i>et al.</i>, “Non-steroidal anti-inflammatory drugs target TWISTED DWARF1-regulated actin dynamics and auxin transport-mediated plant development,” <i>Cell Reports</i>, vol. 33, no. 9. Elsevier, 2020.","ista":"Tan S, Di Donato M, Glanc M, Zhang X, Klíma P, Liu J, Bailly A, Ferro N, Petrášek J, Geisler M, Friml J. 2020. Non-steroidal anti-inflammatory drugs target TWISTED DWARF1-regulated actin dynamics and auxin transport-mediated plant development. Cell Reports. 33(9), 108463.","apa":"Tan, S., Di Donato, M., Glanc, M., Zhang, X., Klíma, P., Liu, J., … Friml, J. (2020). Non-steroidal anti-inflammatory drugs target TWISTED DWARF1-regulated actin dynamics and auxin transport-mediated plant development. <i>Cell Reports</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.celrep.2020.108463\">https://doi.org/10.1016/j.celrep.2020.108463</a>","ama":"Tan S, Di Donato M, Glanc M, et al. Non-steroidal anti-inflammatory drugs target TWISTED DWARF1-regulated actin dynamics and auxin transport-mediated plant development. <i>Cell Reports</i>. 2020;33(9). doi:<a href=\"https://doi.org/10.1016/j.celrep.2020.108463\">10.1016/j.celrep.2020.108463</a>","chicago":"Tan, Shutang, Martin Di Donato, Matous Glanc, Xixi Zhang, Petr Klíma, Jie Liu, Aurélien Bailly, et al. “Non-Steroidal Anti-Inflammatory Drugs Target TWISTED DWARF1-Regulated Actin Dynamics and Auxin Transport-Mediated Plant Development.” <i>Cell Reports</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.celrep.2020.108463\">https://doi.org/10.1016/j.celrep.2020.108463</a>.","short":"S. Tan, M. Di Donato, M. Glanc, X. Zhang, P. Klíma, J. Liu, A. Bailly, N. Ferro, J. Petrášek, M. Geisler, J. Friml, Cell Reports 33 (2020)."},"project":[{"call_identifier":"H2020","_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","grant_number":"742985"},{"call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"},{"name":"Molecular Mechanism underlying Salicylic Acid Regulation of Endocytic Trafficking in Arabidopsis","grant_number":"723-2015","_id":"256FEF10-B435-11E9-9278-68D0E5697425"}]},{"isi":1,"type":"journal_article","oa":1,"article_processing_charge":"No","year":"2020","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_number":"180508","date_published":"2020-11-01T00:00:00Z","date_created":"2020-12-13T23:01:21Z","abstract":[{"text":"Superconductor insulator transition in transverse magnetic field is studied in the highly disordered MoC film with the product of the Fermi momentum and the mean free path kF*l close to unity. Surprisingly, the Zeeman paramagnetic effects dominate over orbital coupling on both sides of the transition. In superconducting state it is evidenced by a high upper critical magnetic field 𝐵𝑐2, by its square root dependence on temperature, as well as by the Zeeman splitting of the quasiparticle density of states (DOS) measured by scanning tunneling microscopy. At 𝐵𝑐2 a logarithmic anomaly in DOS is observed. This anomaly is further enhanced in increasing magnetic field, which is explained by the Zeeman splitting of the Altshuler-Aronov DOS driving\r\nthe system into a more insulating or resistive state. Spin dependent Altshuler-Aronov correction is also needed to explain the transport behavior above 𝐵𝑐2.","lang":"eng"}],"publisher":"American Physical Society","language":[{"iso":"eng"}],"intvolume":"       102","issue":"18","publication":"Physical Review B","month":"11","status":"public","article_type":"original","acknowledgement":"We gratefully acknowledge helpful conversations with B.L. Altshuler and R. Hlubina. The work was supported by the projects APVV-18-0358, VEGA 2/0058/20, VEGA 1/0743/19 the European Microkelvin Platform, the COST action CA16218 (Nanocohybri) and by U.S. Steel Košice. ","publication_identifier":{"issn":["2469-9950"],"eissn":["2469-9969"]},"day":"01","arxiv":1,"external_id":{"isi":["000591509900003"],"arxiv":["2011.04329"]},"author":[{"id":"2DCF8DE6-F248-11E8-B48F-1D18A9856A87","full_name":"Zemlicka, Martin","first_name":"Martin","last_name":"Zemlicka"},{"last_name":"Kopčík","first_name":"M.","full_name":"Kopčík, M."},{"last_name":"Szabó","first_name":"P.","full_name":"Szabó, P."},{"last_name":"Samuely","first_name":"T.","full_name":"Samuely, T."},{"full_name":"Kačmarčík, J.","first_name":"J.","last_name":"Kačmarčík"},{"full_name":"Neilinger, P.","last_name":"Neilinger","first_name":"P."},{"full_name":"Grajcar, M.","first_name":"M.","last_name":"Grajcar"},{"first_name":"P.","last_name":"Samuely","full_name":"Samuely, P."}],"date_updated":"2025-07-10T12:01:27Z","title":"Zeeman-driven superconductor-insulator transition in strongly disordered MoC films: Scanning tunneling microscopy and transport studies in a transverse magnetic field","scopus_import":"1","department":[{"_id":"JoFi"}],"volume":102,"citation":{"short":"M. Zemlicka, M. Kopčík, P. Szabó, T. Samuely, J. Kačmarčík, P. Neilinger, M. Grajcar, P. Samuely, Physical Review B 102 (2020).","chicago":"Zemlicka, Martin, M. Kopčík, P. Szabó, T. Samuely, J. Kačmarčík, P. Neilinger, M. Grajcar, and P. Samuely. “Zeeman-Driven Superconductor-Insulator Transition in Strongly Disordered MoC Films: Scanning Tunneling Microscopy and Transport Studies in a Transverse Magnetic Field.” <i>Physical Review B</i>. American Physical Society, 2020. <a href=\"https://doi.org/10.1103/PhysRevB.102.180508\">https://doi.org/10.1103/PhysRevB.102.180508</a>.","ista":"Zemlicka M, Kopčík M, Szabó P, Samuely T, Kačmarčík J, Neilinger P, Grajcar M, Samuely P. 2020. Zeeman-driven superconductor-insulator transition in strongly disordered MoC films: Scanning tunneling microscopy and transport studies in a transverse magnetic field. Physical Review B. 102(18), 180508.","apa":"Zemlicka, M., Kopčík, M., Szabó, P., Samuely, T., Kačmarčík, J., Neilinger, P., … Samuely, P. (2020). Zeeman-driven superconductor-insulator transition in strongly disordered MoC films: Scanning tunneling microscopy and transport studies in a transverse magnetic field. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.102.180508\">https://doi.org/10.1103/PhysRevB.102.180508</a>","ama":"Zemlicka M, Kopčík M, Szabó P, et al. Zeeman-driven superconductor-insulator transition in strongly disordered MoC films: Scanning tunneling microscopy and transport studies in a transverse magnetic field. <i>Physical Review B</i>. 2020;102(18). doi:<a href=\"https://doi.org/10.1103/PhysRevB.102.180508\">10.1103/PhysRevB.102.180508</a>","ieee":"M. Zemlicka <i>et al.</i>, “Zeeman-driven superconductor-insulator transition in strongly disordered MoC films: Scanning tunneling microscopy and transport studies in a transverse magnetic field,” <i>Physical Review B</i>, vol. 102, no. 18. American Physical Society, 2020.","mla":"Zemlicka, Martin, et al. “Zeeman-Driven Superconductor-Insulator Transition in Strongly Disordered MoC Films: Scanning Tunneling Microscopy and Transport Studies in a Transverse Magnetic Field.” <i>Physical Review B</i>, vol. 102, no. 18, 180508, American Physical Society, 2020, doi:<a href=\"https://doi.org/10.1103/PhysRevB.102.180508\">10.1103/PhysRevB.102.180508</a>."},"doi":"10.1103/PhysRevB.102.180508","_id":"8944","main_file_link":[{"url":"https://arxiv.org/abs/2011.04329","open_access":"1"}],"oa_version":"Preprint","quality_controlled":"1"},{"day":"11","publication_identifier":{"issn":["2073-4409"]},"acknowledgement":"This research was funded by grants from the National Institutes of Health to H.T.G. (R01NS098370 and R01NS089795). C.V.M. was supported by a National Science Foundation Graduate Research Fellowship (DGE-1746939). R.B. was supported by the FWF Lise-Meitner program (M 2416), and S.H. was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 725780 LinPro).The authors thank members of the Ghashghaei lab for discussions, technical support, and help with preparation of the manuscript.","file_date_updated":"2020-12-14T08:09:43Z","article_type":"original","external_id":{"isi":["000601787300001"],"pmid":["33322301"]},"author":[{"first_name":"Xuying","last_name":"Zhang","full_name":"Zhang, Xuying"},{"full_name":"Mennicke, Christine V.","first_name":"Christine V.","last_name":"Mennicke"},{"full_name":"Xiao, Guanxi","first_name":"Guanxi","last_name":"Xiao"},{"full_name":"Beattie, Robert J","id":"2E26DF60-F248-11E8-B48F-1D18A9856A87","first_name":"Robert J","last_name":"Beattie","orcid":"0000-0002-8483-8753"},{"last_name":"Haider","first_name":"Mansoor","full_name":"Haider, Mansoor"},{"first_name":"Simon","last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Ghashghaei","first_name":"H. Troy","full_name":"Ghashghaei, H. Troy"}],"title":"Clonal analysis of gliogenesis in the cerebral cortex reveals stochastic expansion of glia and cell autonomous responses to Egfr dosage","date_updated":"2025-06-12T07:02:43Z","volume":9,"scopus_import":"1","department":[{"_id":"SiHi"}],"doi":"10.3390/cells9122662","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"citation":{"short":"X. Zhang, C.V. Mennicke, G. Xiao, R.J. Beattie, M. Haider, S. Hippenmeyer, H.T. Ghashghaei, Cells 9 (2020).","chicago":"Zhang, Xuying, Christine V. Mennicke, Guanxi Xiao, Robert J Beattie, Mansoor Haider, Simon Hippenmeyer, and H. Troy Ghashghaei. “Clonal Analysis of Gliogenesis in the Cerebral Cortex Reveals Stochastic Expansion of Glia and Cell Autonomous Responses to Egfr Dosage.” <i>Cells</i>. MDPI, 2020. <a href=\"https://doi.org/10.3390/cells9122662\">https://doi.org/10.3390/cells9122662</a>.","ama":"Zhang X, Mennicke CV, Xiao G, et al. Clonal analysis of gliogenesis in the cerebral cortex reveals stochastic expansion of glia and cell autonomous responses to Egfr dosage. <i>Cells</i>. 2020;9(12). doi:<a href=\"https://doi.org/10.3390/cells9122662\">10.3390/cells9122662</a>","ista":"Zhang X, Mennicke CV, Xiao G, Beattie RJ, Haider M, Hippenmeyer S, Ghashghaei HT. 2020. Clonal analysis of gliogenesis in the cerebral cortex reveals stochastic expansion of glia and cell autonomous responses to Egfr dosage. Cells. 9(12), 2662.","apa":"Zhang, X., Mennicke, C. V., Xiao, G., Beattie, R. J., Haider, M., Hippenmeyer, S., &#38; Ghashghaei, H. T. (2020). Clonal analysis of gliogenesis in the cerebral cortex reveals stochastic expansion of glia and cell autonomous responses to Egfr dosage. <i>Cells</i>. MDPI. <a href=\"https://doi.org/10.3390/cells9122662\">https://doi.org/10.3390/cells9122662</a>","mla":"Zhang, Xuying, et al. “Clonal Analysis of Gliogenesis in the Cerebral Cortex Reveals Stochastic Expansion of Glia and Cell Autonomous Responses to Egfr Dosage.” <i>Cells</i>, vol. 9, no. 12, 2662, MDPI, 2020, doi:<a href=\"https://doi.org/10.3390/cells9122662\">10.3390/cells9122662</a>.","ieee":"X. Zhang <i>et al.</i>, “Clonal analysis of gliogenesis in the cerebral cortex reveals stochastic expansion of glia and cell autonomous responses to Egfr dosage,” <i>Cells</i>, vol. 9, no. 12. MDPI, 2020."},"project":[{"call_identifier":"FWF","_id":"264E56E2-B435-11E9-9278-68D0E5697425","name":"Molecular Mechanisms Regulating Gliogenesis in the Neocortex","grant_number":"M02416"},{"grant_number":"725780","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","_id":"260018B0-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"oa_version":"Published Version","quality_controlled":"1","_id":"8949","oa":1,"ec_funded":1,"isi":1,"type":"journal_article","file":[{"date_updated":"2020-12-14T08:09:43Z","success":1,"file_id":"8950","access_level":"open_access","content_type":"application/pdf","file_size":3504525,"checksum":"5095cbdc728c9a510c5761cf60a8861c","creator":"dernst","file_name":"2020_Cells_Zhang.pdf","date_created":"2020-12-14T08:09:43Z","relation":"main_file"}],"publication_status":"published","year":"2020","article_processing_charge":"No","date_published":"2020-12-11T00:00:00Z","article_number":"2662","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"MDPI","date_created":"2020-12-14T08:04:03Z","has_accepted_license":"1","abstract":[{"text":"<jats:p>Development of the nervous system undergoes important transitions, including one from neurogenesis to gliogenesis which occurs late during embryonic gestation. Here we report on clonal analysis of gliogenesis in mice using Mosaic Analysis with Double Markers (MADM) with quantitative and computational methods. Results reveal that developmental gliogenesis in the cerebral cortex occurs in a fraction of earlier neurogenic clones, accelerating around E16.5, and giving rise to both astrocytes and oligodendrocytes. Moreover, MADM-based genetic deletion of the epidermal growth factor receptor (Egfr) in gliogenic clones revealed that Egfr is cell autonomously required for gliogenesis in the mouse dorsolateral cortices. A broad range in the proliferation capacity, symmetry of clones, and competitive advantage of MADM cells was evident in clones that contained one cellular lineage with double dosage of Egfr relative to their environment, while their sibling Egfr-null cells failed to generate glia. Remarkably, the total numbers of glia in MADM clones balance out regardless of significant alterations in clonal symmetries. The variability in glial clones shows stochastic patterns that we define mathematically, which are different from the deterministic patterns in neuronal clones. This study sets a foundation for studying the biological significance of stochastic and deterministic clonal principles underlying tissue development, and identifying mechanisms that differentiate between neurogenesis and gliogenesis.</jats:p>","lang":"eng"}],"pmid":1,"intvolume":"         9","language":[{"iso":"eng"}],"issue":"12","ddc":["570"],"status":"public","month":"12","publication":"Cells"},{"author":[{"id":"3ABC5BA6-F248-11E8-B48F-1D18A9856A87","full_name":"Nagy-Staron, Anna A","first_name":"Anna A","orcid":"0000-0002-1391-8377","last_name":"Nagy-Staron"}],"file":[{"date_created":"2020-12-20T09:52:52Z","relation":"main_file","file_name":"readme.txt","checksum":"f57862aeee1690c7effd2b1117d40ed1","creator":"bkavcic","file_size":523,"access_level":"open_access","content_type":"text/plain","file_id":"8952","success":1,"date_updated":"2020-12-20T09:52:52Z"},{"file_id":"8954","success":1,"date_updated":"2020-12-20T22:01:44Z","date_created":"2020-12-20T22:01:44Z","relation":"main_file","checksum":"f2c6d5232ec6d551b6993991e8689e9f","file_name":"GRNs Research depository.gb","creator":"bkavcic","file_size":379228,"access_level":"open_access","content_type":"application/octet-stream"}],"keyword":["Gene regulatory networks","Gene expression","Escherichia coli","Synthetic Biology"],"article_processing_charge":"No","year":"2020","title":"Sequences of gene regulatory network permutations for the article \"Local genetic context shapes the function of a gene regulatory network\"","date_updated":"2025-06-12T06:36:16Z","date_published":"2020-12-21T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"21","file_date_updated":"2020-12-20T22:01:44Z","related_material":{"record":[{"id":"9283","relation":"used_in_publication","status":"public"}]},"oa":1,"contributor":[{"id":"3ABC5BA6-F248-11E8-B48F-1D18A9856A87","contributor_type":"project_member","first_name":"Anna A","last_name":"Nagy-Staron"},{"id":"3AEC8556-F248-11E8-B48F-1D18A9856A87","contributor_type":"project_member","first_name":"Kathrin","last_name":"Tomasek"},{"last_name":"Caruso Carter","first_name":"Caroline","contributor_type":"project_member"},{"last_name":"Sonnleitner","first_name":"Elisabeth","contributor_type":"project_member"},{"orcid":"0000-0001-6041-254X","last_name":"Kavcic","first_name":"Bor","contributor_type":"project_member","id":"350F91D2-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Paixão","first_name":"Tiago","contributor_type":"project_member"},{"first_name":"Calin C","orcid":"0000-0001-6220-2052","last_name":"Guet","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","contributor_type":"project_manager"}],"type":"research_data","ddc":["570"],"corr_author":"1","oa_version":"Published Version","status":"public","month":"12","_id":"8951","publisher":"Institute of Science and Technology Austria","department":[{"_id":"CaGu"}],"abstract":[{"lang":"eng","text":"Gene expression levels are influenced by multiple coexisting molecular mechanisms. Some of these interactions, such as those of transcription factors and promoters have been studied extensively. However, predicting phenotypes of gene regulatory networks remains a major challenge. Here, we use a well-defined synthetic gene regulatory network to study how network phenotypes depend on local genetic context, i.e. the genetic neighborhood of a transcription factor and its relative position. We show that one gene regulatory network with fixed topology can display not only quantitatively but also qualitatively different phenotypes, depending solely on the local genetic context of its components. Our results demonstrate that changes in local genetic context can place a single transcriptional unit within two separate regulons without the need for complex regulatory sequences. We propose that relative order of individual transcriptional units, with its potential for combinatorial complexity, plays an important role in shaping phenotypes of gene regulatory networks."}],"date_created":"2020-12-20T10:00:26Z","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.15479/AT:ISTA:8951","citation":{"short":"A.A. Nagy-Staron, (2020).","chicago":"Nagy-Staron, Anna A. “Sequences of Gene Regulatory Network Permutations for the Article ‘Local Genetic Context Shapes the Function of a Gene Regulatory Network.’” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8951\">https://doi.org/10.15479/AT:ISTA:8951</a>.","apa":"Nagy-Staron, A. A. (2020). Sequences of gene regulatory network permutations for the article “Local genetic context shapes the function of a gene regulatory network.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8951\">https://doi.org/10.15479/AT:ISTA:8951</a>","ama":"Nagy-Staron AA. Sequences of gene regulatory network permutations for the article “Local genetic context shapes the function of a gene regulatory network.” 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8951\">10.15479/AT:ISTA:8951</a>","ista":"Nagy-Staron AA. 2020. Sequences of gene regulatory network permutations for the article ‘Local genetic context shapes the function of a gene regulatory network’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:8951\">10.15479/AT:ISTA:8951</a>.","ieee":"A. A. Nagy-Staron, “Sequences of gene regulatory network permutations for the article ‘Local genetic context shapes the function of a gene regulatory network.’” Institute of Science and Technology Austria, 2020.","mla":"Nagy-Staron, Anna A. <i>Sequences of Gene Regulatory Network Permutations for the Article “Local Genetic Context Shapes the Function of a Gene Regulatory Network.”</i> Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8951\">10.15479/AT:ISTA:8951</a>."}},{"_id":"8955","quality_controlled":"1","oa_version":"Published Version","project":[{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"doi":"10.3389/fphys.2020.558070","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"citation":{"short":"R. Rizzo, X. Zhang, J.W.J.L. Wang, F. Lombardi, P.C. Ivanov, Frontiers in Physiology 11 (2020).","chicago":"Rizzo, Rossella, Xiyun Zhang, Jilin W.J.L. Wang, Fabrizio Lombardi, and Plamen Ch Ivanov. “Network Physiology of Cortico–Muscular Interactions.” <i>Frontiers in Physiology</i>. Frontiers, 2020. <a href=\"https://doi.org/10.3389/fphys.2020.558070\">https://doi.org/10.3389/fphys.2020.558070</a>.","apa":"Rizzo, R., Zhang, X., Wang, J. W. J. L., Lombardi, F., &#38; Ivanov, P. C. (2020). Network physiology of cortico–muscular interactions. <i>Frontiers in Physiology</i>. Frontiers. <a href=\"https://doi.org/10.3389/fphys.2020.558070\">https://doi.org/10.3389/fphys.2020.558070</a>","ista":"Rizzo R, Zhang X, Wang JWJL, Lombardi F, Ivanov PC. 2020. Network physiology of cortico–muscular interactions. Frontiers in Physiology. 11, 558070.","ama":"Rizzo R, Zhang X, Wang JWJL, Lombardi F, Ivanov PC. Network physiology of cortico–muscular interactions. <i>Frontiers in Physiology</i>. 2020;11. doi:<a href=\"https://doi.org/10.3389/fphys.2020.558070\">10.3389/fphys.2020.558070</a>","mla":"Rizzo, Rossella, et al. “Network Physiology of Cortico–Muscular Interactions.” <i>Frontiers in Physiology</i>, vol. 11, 558070, Frontiers, 2020, doi:<a href=\"https://doi.org/10.3389/fphys.2020.558070\">10.3389/fphys.2020.558070</a>.","ieee":"R. Rizzo, X. Zhang, J. W. J. L. Wang, F. Lombardi, and P. C. Ivanov, “Network physiology of cortico–muscular interactions,” <i>Frontiers in Physiology</i>, vol. 11. Frontiers, 2020."},"scopus_import":"1","department":[{"_id":"GaTk"}],"volume":11,"date_updated":"2025-04-14T07:43:50Z","title":"Network physiology of cortico–muscular interactions","author":[{"full_name":"Rizzo, Rossella","last_name":"Rizzo","first_name":"Rossella"},{"full_name":"Zhang, Xiyun","first_name":"Xiyun","last_name":"Zhang"},{"full_name":"Wang, Jilin W.J.L.","last_name":"Wang","first_name":"Jilin W.J.L."},{"last_name":"Lombardi","orcid":"0000-0003-2623-5249","first_name":"Fabrizio","full_name":"Lombardi, Fabrizio","id":"A057D288-3E88-11E9-986D-0CF4E5697425"},{"first_name":"Plamen Ch","last_name":"Ivanov","full_name":"Ivanov, Plamen Ch"}],"external_id":{"pmid":["33324233"],"isi":["000596849400001"]},"article_type":"original","publication_identifier":{"eissn":["1664042X"]},"acknowledgement":"We acknowledge support from the W. M. Keck Foundation, National Institutes of Health (NIH Grant 1R01-HL098437), the US-Israel Binational Science Foundation (BSF Grant 2012219), and the Office of Naval Research (ONR Grant 000141010078). FL acknowledges support also from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement No. 754411.","file_date_updated":"2020-12-21T10:37:50Z","day":"26","publication":"Frontiers in Physiology","month":"11","ddc":["570"],"status":"public","language":[{"iso":"eng"}],"intvolume":"        11","pmid":1,"date_created":"2020-12-20T23:01:18Z","has_accepted_license":"1","abstract":[{"text":"Skeletal muscle activity is continuously modulated across physiologic states to provide coordination, flexibility and responsiveness to body tasks and external inputs. Despite the central role the muscular system plays in facilitating vital body functions, the network of brain-muscle interactions required to control hundreds of muscles and synchronize their activation in relation to distinct physiologic states has not been investigated. Recent approaches have focused on general associations between individual brain rhythms and muscle activation during movement tasks. However, the specific forms of coupling, the functional network of cortico-muscular coordination, and how network structure and dynamics are modulated by autonomic regulation across physiologic states remains unknown. To identify and quantify the cortico-muscular interaction network and uncover basic features of neuro-autonomic control of muscle function, we investigate the coupling between synchronous bursts in cortical rhythms and peripheral muscle activation during sleep and wake. Utilizing the concept of time delay stability and a novel network physiology approach, we find that the brain-muscle network exhibits complex dynamic patterns of communication involving multiple brain rhythms across cortical locations and different electromyographic frequency bands. Moreover, our results show that during each physiologic state the cortico-muscular network is characterized by a specific profile of network links strength, where particular brain rhythms play role of main mediators of interaction and control. Further, we discover a hierarchical reorganization in network structure across physiologic states, with high connectivity and network link strength during wake, intermediate during REM and light sleep, and low during deep sleep, a sleep-stage stratification that demonstrates a unique association between physiologic states and cortico-muscular network structure. The reported empirical observations are consistent across individual subjects, indicating universal behavior in network structure and dynamics, and high sensitivity of cortico-muscular control to changes in autonomic regulation, even at low levels of physical activity and muscle tone during sleep. Our findings demonstrate previously unrecognized basic principles of brain-muscle network communication and control, and provide new perspectives on the regulatory mechanisms of brain dynamics and locomotor activation, with potential clinical implications for neurodegenerative, movement and sleep disorders, and for developing efficient treatment strategies.","lang":"eng"}],"publisher":"Frontiers","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_published":"2020-11-26T00:00:00Z","article_number":"558070","year":"2020","article_processing_charge":"No","publication_status":"published","file":[{"content_type":"application/pdf","access_level":"open_access","file_size":13380030,"creator":"dernst","checksum":"ef9515b28c5619b7126c0f347958bcb3","file_name":"2020_Frontiers_Rizzo.pdf","relation":"main_file","date_created":"2020-12-21T10:37:50Z","date_updated":"2020-12-21T10:37:50Z","file_id":"8961","success":1}],"type":"journal_article","isi":1,"ec_funded":1,"oa":1},{"date_published":"2020-12-22T00:00:00Z","article_number":"6437","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","file":[{"creator":"dernst","checksum":"55d43ea0061cc4027ba45e966e1db8cc","file_name":"2020_NatureComm_Faessler.pdf","relation":"main_file","date_created":"2020-12-28T08:16:10Z","content_type":"application/pdf","access_level":"open_access","file_size":3958727,"file_id":"8975","success":1,"date_updated":"2020-12-28T08:16:10Z"}],"publication_status":"published","year":"2020","keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"article_processing_charge":"No","oa":1,"type":"journal_article","isi":1,"month":"12","publication":"Nature Communications","status":"public","corr_author":"1","ddc":["570"],"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"EM-Fac"}],"intvolume":"        11","language":[{"iso":"eng"}],"publisher":"Springer Nature","abstract":[{"text":"The actin-related protein (Arp)2/3 complex nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen infection. Its activation is tightly regulated and involves complex structural rearrangements and actin filament binding, which are yet to be understood. Here, we report a 9.0 Å resolution structure of the actin filament Arp2/3 complex branch junction in cells using cryo-electron tomography and subtomogram averaging. This allows us to generate an accurate model of the active Arp2/3 complex in the branch junction and its interaction with actin filaments. Notably, our model reveals a previously undescribed set of interactions of the Arp2/3 complex with the mother filament, significantly different to the previous branch junction model. Our structure also indicates a central role for the ArpC3 subunit in stabilizing the active conformation.","lang":"eng"}],"has_accepted_license":"1","date_created":"2020-12-23T08:25:45Z","title":"Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction","date_updated":"2025-04-15T07:52:12Z","author":[{"last_name":"Fäßler","orcid":"0000-0001-7149-769X","first_name":"Florian","full_name":"Fäßler, Florian","id":"404F5528-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Georgi A","orcid":"0000-0001-8370-6161","last_name":"Dimchev","id":"38C393BE-F248-11E8-B48F-1D18A9856A87","full_name":"Dimchev, Georgi A"},{"id":"3661B498-F248-11E8-B48F-1D18A9856A87","full_name":"Hodirnau, Victor-Valentin","orcid":"0000-0003-3904-947X","last_name":"Hodirnau","first_name":"Victor-Valentin"},{"full_name":"Wan, William","first_name":"William","last_name":"Wan"},{"id":"48AD8942-F248-11E8-B48F-1D18A9856A87","full_name":"Schur, Florian KM","orcid":"0000-0003-4790-8078","last_name":"Schur","first_name":"Florian KM"}],"external_id":{"isi":["000603078000003"]},"day":"22","file_date_updated":"2020-12-28T08:16:10Z","acknowledgement":"This research was supported by the Scientific Service Units (SSUs) of IST Austria through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), the BioImaging Facility (BIF), and the Electron Microscopy Facility (EMF). We also thank Dimitry Tegunov (MPI for Biophysical Chemistry) for helpful discussions\r\nabout the M software, and Michael Sixt (IST Austria) and Klemens Rottner (Technical University Braunschweig, HZI Braunschweig) for critical reading of the manuscript. We also thank Gregory Voth (University of Chicago) for providing us the MD-derived branch junction model for comparison. The authors acknowledge support from IST Austria and from the Austrian Science Fund (FWF): M02495 to G.D. and Austrian Science Fund (FWF): P33367 to F.K.M.S. ","article_type":"original","publication_identifier":{"issn":["2041-1723"]},"related_material":{"link":[{"url":"https://ist.ac.at/en/news/cutting-edge-technology-reveals-structures-within-cells/","relation":"press_release","description":"News on IST Homepage"}]},"quality_controlled":"1","oa_version":"Published Version","_id":"8971","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"citation":{"ista":"Fäßler F, Dimchev GA, Hodirnau V-V, Wan W, Schur FK. 2020. Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. Nature Communications. 11, 6437.","ama":"Fäßler F, Dimchev GA, Hodirnau V-V, Wan W, Schur FK. Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-20286-x\">10.1038/s41467-020-20286-x</a>","apa":"Fäßler, F., Dimchev, G. A., Hodirnau, V.-V., Wan, W., &#38; Schur, F. K. (2020). Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-20286-x\">https://doi.org/10.1038/s41467-020-20286-x</a>","mla":"Fäßler, Florian, et al. “Cryo-Electron Tomography Structure of Arp2/3 Complex in Cells Reveals New Insights into the Branch Junction.” <i>Nature Communications</i>, vol. 11, 6437, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-20286-x\">10.1038/s41467-020-20286-x</a>.","ieee":"F. Fäßler, G. A. Dimchev, V.-V. Hodirnau, W. Wan, and F. K. Schur, “Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","short":"F. Fäßler, G.A. Dimchev, V.-V. Hodirnau, W. Wan, F.K. Schur, Nature Communications 11 (2020).","chicago":"Fäßler, Florian, Georgi A Dimchev, Victor-Valentin Hodirnau, William Wan, and Florian KM Schur. “Cryo-Electron Tomography Structure of Arp2/3 Complex in Cells Reveals New Insights into the Branch Junction.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-20286-x\">https://doi.org/10.1038/s41467-020-20286-x</a>."},"doi":"10.1038/s41467-020-20286-x","project":[{"grant_number":"P33367","name":"Structure and isoform diversity of the Arp2/3 complex","_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A"},{"call_identifier":"FWF","_id":"2674F658-B435-11E9-9278-68D0E5697425","name":"Protein structure and function in filopodia across scales","grant_number":"M02495"}],"volume":11,"scopus_import":"1","department":[{"_id":"FlSc"},{"_id":"EM-Fac"}]},{"date_updated":"2025-04-15T08:23:06Z","title":"Generation and isolation of single cells from mouse brain with mosaic analysis with double markers-induced uniparental chromosome disomy","author":[{"first_name":"Susanne","last_name":"Laukoter","orcid":"0000-0002-7903-3010","full_name":"Laukoter, Susanne","id":"2D6B7A9A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Amberg, Nicole","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","first_name":"Nicole","last_name":"Amberg","orcid":"0000-0002-3183-8207"},{"id":"48EA0138-F248-11E8-B48F-1D18A9856A87","full_name":"Pauler, Florian","orcid":"0000-0002-7462-0048","last_name":"Pauler","first_name":"Florian"},{"id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer","first_name":"Simon"}],"external_id":{"pmid":["33377108"]},"article_type":"original","acknowledgement":"This research was supported by the Scientific Service Units (SSU) at IST Austria through resources provided by the Bioimaging (BIF) and Preclinical Facilities (PCF). N.A received support from the FWF Firnberg-Programm (T 1031). This work was also supported by IST Austria institutional funds; FWF SFB F78 to S.H.; NÖ Forschung und Bildung n[f+b] life science call grant (C13-002) to S.H.; the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no. 618444 to S.H.; and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 725780 LinPro) to S.H.","publication_identifier":{"issn":["2666-1667"]},"file_date_updated":"2021-01-07T15:57:27Z","day":"18","oa_version":"Published Version","quality_controlled":"1","_id":"8978","tmp":{"image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"doi":"10.1016/j.xpro.2020.100215","citation":{"ieee":"S. Laukoter, N. Amberg, F. Pauler, and S. Hippenmeyer, “Generation and isolation of single cells from mouse brain with mosaic analysis with double markers-induced uniparental chromosome disomy,” <i>STAR Protocols</i>, vol. 1, no. 3. Elsevier, 2020.","mla":"Laukoter, Susanne, et al. “Generation and Isolation of Single Cells from Mouse Brain with Mosaic Analysis with Double Markers-Induced Uniparental Chromosome Disomy.” <i>STAR Protocols</i>, vol. 1, no. 3, 100215, Elsevier, 2020, doi:<a href=\"https://doi.org/10.1016/j.xpro.2020.100215\">10.1016/j.xpro.2020.100215</a>.","ista":"Laukoter S, Amberg N, Pauler F, Hippenmeyer S. 2020. Generation and isolation of single cells from mouse brain with mosaic analysis with double markers-induced uniparental chromosome disomy. STAR Protocols. 1(3), 100215.","apa":"Laukoter, S., Amberg, N., Pauler, F., &#38; Hippenmeyer, S. (2020). Generation and isolation of single cells from mouse brain with mosaic analysis with double markers-induced uniparental chromosome disomy. <i>STAR Protocols</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.xpro.2020.100215\">https://doi.org/10.1016/j.xpro.2020.100215</a>","ama":"Laukoter S, Amberg N, Pauler F, Hippenmeyer S. Generation and isolation of single cells from mouse brain with mosaic analysis with double markers-induced uniparental chromosome disomy. <i>STAR Protocols</i>. 2020;1(3). doi:<a href=\"https://doi.org/10.1016/j.xpro.2020.100215\">10.1016/j.xpro.2020.100215</a>","chicago":"Laukoter, Susanne, Nicole Amberg, Florian Pauler, and Simon Hippenmeyer. “Generation and Isolation of Single Cells from Mouse Brain with Mosaic Analysis with Double Markers-Induced Uniparental Chromosome Disomy.” <i>STAR Protocols</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.xpro.2020.100215\">https://doi.org/10.1016/j.xpro.2020.100215</a>.","short":"S. Laukoter, N. Amberg, F. Pauler, S. Hippenmeyer, STAR Protocols 1 (2020)."},"project":[{"call_identifier":"FWF","_id":"268F8446-B435-11E9-9278-68D0E5697425","name":"Role of Eed in neural stem cell lineage progression","grant_number":"T01031"},{"_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E","name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression","grant_number":"F7805"},{"grant_number":"LS13-002","name":"Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain","_id":"25D92700-B435-11E9-9278-68D0E5697425"},{"grant_number":"618444","name":"Molecular Mechanisms of Cerebral Cortex Development","_id":"25D61E48-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"},{"call_identifier":"H2020","_id":"260018B0-B435-11E9-9278-68D0E5697425","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780"}],"volume":1,"department":[{"_id":"SiHi"}],"scopus_import":"1","date_published":"2020-12-18T00:00:00Z","article_number":"100215","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"creator":"dernst","checksum":"f1e9a433e9cb0f41f7b6df6b76db1f6e","file_name":"2020_STARProtocols_Laukoter.pdf","relation":"main_file","date_created":"2021-01-07T15:57:27Z","content_type":"application/pdf","access_level":"open_access","file_size":4031449,"file_id":"8996","success":1,"date_updated":"2021-01-07T15:57:27Z"}],"year":"2020","article_processing_charge":"No","publication_status":"published","oa":1,"type":"journal_article","ec_funded":1,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"ddc":["570"],"publication":"STAR Protocols","month":"12","corr_author":"1","status":"public","issue":"3","intvolume":"         1","language":[{"iso":"eng"}],"publisher":"Elsevier","pmid":1,"date_created":"2020-12-30T10:17:07Z","has_accepted_license":"1","abstract":[{"text":"Mosaic analysis with double markers (MADM) technology enables concomitant fluorescent cell labeling and induction of uniparental chromosome disomy (UPD) with single-cell resolution. In UPD, imprinted genes are either overexpressed 2-fold or are not expressed. Here, the MADM platform is utilized to probe imprinting phenotypes at the transcriptional level. This protocol highlights major steps for the generation and isolation of projection neurons and astrocytes with MADM-induced UPD from mouse cerebral cortex for downstream single-cell and low-input sample RNA-sequencing experiments.\r\n\r\nFor complete details on the use and execution of this protocol, please refer to Laukoter et al. (2020b).","lang":"eng"}]},{"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2020-12-08T00:00:00Z","year":"2020","article_processing_charge":"No","publication_status":"published","series_title":"LNCS","type":"conference","isi":1,"ec_funded":1,"oa":1,"page":"3-15","status":"public","publication":"Progress in Cryptology","month":"12","language":[{"iso":"eng"}],"intvolume":"     12578","abstract":[{"lang":"eng","text":"Currently several projects aim at designing and implementing protocols for privacy preserving automated contact tracing to help fight the current pandemic. Those proposal are quite similar, and in their most basic form basically propose an app for mobile phones which broadcasts frequently changing pseudorandom identifiers via (low energy) Bluetooth, and at the same time, the app stores IDs broadcast by phones in its proximity. Only if a user is tested positive, they upload either the beacons they did broadcast (which is the case in decentralized proposals as DP-3T, east and west coast PACT or Covid watch) or received (as in Popp-PT or ROBERT) during the last two weeks or so.\r\n\r\nVaudenay [eprint 2020/399] observes that this basic scheme (he considers the DP-3T proposal) succumbs to relay and even replay attacks, and proposes more complex interactive schemes which prevent those attacks without giving up too many privacy aspects. Unfortunately interaction is problematic for this application for efficiency and security reasons. The countermeasures that have been suggested so far are either not practical or give up on key privacy aspects. We propose a simple non-interactive variant of the basic protocol that\r\n(security) Provably prevents replay and (if location data is available) relay attacks.\r\n(privacy) The data of all parties (even jointly) reveals no information on the location or time where encounters happened.\r\n(efficiency) The broadcasted message can fit into 128 bits and uses only basic crypto (commitments and secret key authentication).\r\n\r\nTowards this end we introduce the concept of “delayed authentication”, which basically is a message authentication code where verification can be done in two steps, where the first doesn’t require the key, and the second doesn’t require the message."}],"date_created":"2021-01-03T23:01:23Z","publisher":"Springer Nature","date_updated":"2026-04-16T09:33:26Z","title":"Delayed authentication: Preventing replay and relay attacks in private contact tracing","author":[{"id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","full_name":"Pietrzak, Krzysztof Z","orcid":"0000-0002-9139-1654","last_name":"Pietrzak","first_name":"Krzysztof Z"}],"conference":{"name":"INDOCRYPT: International Conference on Cryptology in India","location":"Bangalore, India","start_date":"2020-12-13","end_date":"2020-12-16"},"external_id":{"isi":["000927592800001"]},"publication_identifier":{"eissn":["1611-3349"],"issn":["0302-9743"],"isbn":["9783030652760"]},"day":"08","_id":"8987","main_file_link":[{"open_access":"1","url":"https://eprint.iacr.org/2020/418"}],"oa_version":"Preprint","quality_controlled":"1","project":[{"name":"Teaching Old Crypto New Tricks","grant_number":"682815","call_identifier":"H2020","_id":"258AA5B2-B435-11E9-9278-68D0E5697425"}],"citation":{"chicago":"Pietrzak, Krzysztof Z. “Delayed Authentication: Preventing Replay and Relay Attacks in Private Contact Tracing.” In <i>Progress in Cryptology</i>, 12578:3–15. LNCS. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/978-3-030-65277-7_1\">https://doi.org/10.1007/978-3-030-65277-7_1</a>.","short":"K.Z. Pietrzak, in:, Progress in Cryptology, Springer Nature, 2020, pp. 3–15.","mla":"Pietrzak, Krzysztof Z. “Delayed Authentication: Preventing Replay and Relay Attacks in Private Contact Tracing.” <i>Progress in Cryptology</i>, vol. 12578, Springer Nature, 2020, pp. 3–15, doi:<a href=\"https://doi.org/10.1007/978-3-030-65277-7_1\">10.1007/978-3-030-65277-7_1</a>.","ieee":"K. Z. Pietrzak, “Delayed authentication: Preventing replay and relay attacks in private contact tracing,” in <i>Progress in Cryptology</i>, Bangalore, India, 2020, vol. 12578, pp. 3–15.","ista":"Pietrzak KZ. 2020. Delayed authentication: Preventing replay and relay attacks in private contact tracing. Progress in Cryptology. INDOCRYPT: International Conference on Cryptology in IndiaLNCS vol. 12578, 3–15.","apa":"Pietrzak, K. Z. (2020). Delayed authentication: Preventing replay and relay attacks in private contact tracing. In <i>Progress in Cryptology</i> (Vol. 12578, pp. 3–15). Bangalore, India: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-65277-7_1\">https://doi.org/10.1007/978-3-030-65277-7_1</a>","ama":"Pietrzak KZ. Delayed authentication: Preventing replay and relay attacks in private contact tracing. In: <i>Progress in Cryptology</i>. Vol 12578. LNCS. Springer Nature; 2020:3-15. doi:<a href=\"https://doi.org/10.1007/978-3-030-65277-7_1\">10.1007/978-3-030-65277-7_1</a>"},"doi":"10.1007/978-3-030-65277-7_1","scopus_import":"1","department":[{"_id":"KrPi"}],"volume":12578},{"project":[{"_id":"2665AAFE-B435-11E9-9278-68D0E5697425","name":"Can evolution minimize spurious signaling crosstalk to reach optimal performance?","grant_number":"RGP0034/2018"},{"name":"Biophysically realistic genotype-phenotype maps for regulatory networks","_id":"267C84F4-B435-11E9-9278-68D0E5697425"}],"citation":{"chicago":"Grah, Rok, Benjamin Zoller, and Gašper Tkačik. “Nonequilibrium Models of Optimal Enhancer Function.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2020. <a href=\"https://doi.org/10.1073/pnas.2006731117\">https://doi.org/10.1073/pnas.2006731117</a>.","short":"R. Grah, B. Zoller, G. Tkačik, Proceedings of the National Academy of Sciences of the United States of America 117 (2020) 31614–31622.","mla":"Grah, Rok, et al. “Nonequilibrium Models of Optimal Enhancer Function.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 117, no. 50, National Academy of Sciences, 2020, pp. 31614–22, doi:<a href=\"https://doi.org/10.1073/pnas.2006731117\">10.1073/pnas.2006731117</a>.","ieee":"R. Grah, B. Zoller, and G. Tkačik, “Nonequilibrium models of optimal enhancer function,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 117, no. 50. National Academy of Sciences, pp. 31614–31622, 2020.","ista":"Grah R, Zoller B, Tkačik G. 2020. Nonequilibrium models of optimal enhancer function. Proceedings of the National Academy of Sciences of the United States of America. 117(50), 31614–31622.","apa":"Grah, R., Zoller, B., &#38; Tkačik, G. (2020). Nonequilibrium models of optimal enhancer function. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2006731117\">https://doi.org/10.1073/pnas.2006731117</a>","ama":"Grah R, Zoller B, Tkačik G. Nonequilibrium models of optimal enhancer function. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2020;117(50):31614-31622. doi:<a href=\"https://doi.org/10.1073/pnas.2006731117\">10.1073/pnas.2006731117</a>"},"tmp":{"image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"doi":"10.1073/pnas.2006731117","scopus_import":"1","department":[{"_id":"GaTk"}],"volume":117,"_id":"9000","oa_version":"Published Version","quality_controlled":"1","external_id":{"pmid":["33268497"],"isi":["000600608300015"]},"day":"15","file_date_updated":"2021-01-11T08:37:31Z","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/new-compact-model-for-gene-regulation-in-higher-organisms/","description":"News on IST Homepage"}]},"publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"article_type":"original","acknowledgement":"G.T. was supported by Human Frontiers Science Program Grant RGP0034/2018. R.G. was supported by the Austrian Academy of Sciences DOC Fellowship. R.G. thanks S. Avvakumov for helpful discussions.","title":"Nonequilibrium models of optimal enhancer function","date_updated":"2025-05-14T10:57:50Z","author":[{"last_name":"Grah","orcid":"0000-0003-2539-3560","first_name":"Rok","full_name":"Grah, Rok","id":"483E70DE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Benjamin","last_name":"Zoller","full_name":"Zoller, Benjamin"},{"id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","full_name":"Tkačik, Gašper","first_name":"Gašper","orcid":"0000-0002-6699-1455","last_name":"Tkačik"}],"language":[{"iso":"eng"}],"intvolume":"       117","abstract":[{"lang":"eng","text":"In prokaryotes, thermodynamic models of gene regulation provide a highly quantitative mapping from promoter sequences to gene-expression levels that is compatible with in vivo and in vitro biophysical measurements. Such concordance has not been achieved for models of enhancer function in eukaryotes. In equilibrium models, it is difficult to reconcile the reported short transcription factor (TF) residence times on the DNA with the high specificity of regulation. In nonequilibrium models, progress is difficult due to an explosion in the number of parameters. Here, we navigate this complexity by looking for minimal nonequilibrium enhancer models that yield desired regulatory phenotypes: low TF residence time, high specificity, and tunable cooperativity. We find that a single extra parameter, interpretable as the “linking rate,” by which bound TFs interact with Mediator components, enables our models to escape equilibrium bounds and access optimal regulatory phenotypes, while remaining consistent with the reported phenomenology and simple enough to be inferred from upcoming experiments. We further find that high specificity in nonequilibrium models is in a trade-off with gene-expression noise, predicting bursty dynamics—an experimentally observed hallmark of eukaryotic transcription. By drastically reducing the vast parameter space of nonequilibrium enhancer models to a much smaller subspace that optimally realizes biological function, we deliver a rich class of models that could be tractably inferred from data in the near future."}],"has_accepted_license":"1","pmid":1,"date_created":"2021-01-10T23:01:17Z","publisher":"National Academy of Sciences","ddc":["570"],"publication":"Proceedings of the National Academy of Sciences of the United States of America","status":"public","month":"12","corr_author":"1","issue":"50","isi":1,"type":"journal_article","oa":1,"page":"31614-31622","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2020-12-15T00:00:00Z","publication_status":"published","article_processing_charge":"No","year":"2020","file":[{"file_size":1199247,"access_level":"open_access","content_type":"application/pdf","date_created":"2021-01-11T08:37:31Z","relation":"main_file","checksum":"69039cd402a571983aa6cb4815ffa863","creator":"dernst","file_name":"2020_PNAS_Grah.pdf","date_updated":"2021-01-11T08:37:31Z","file_id":"9004","success":1}]}]