[{"_id":"17693","oa_version":"Published Version","scopus_import":"1","publisher":"Oxford University Press","abstract":[{"lang":"eng","text":"We perform one-dimensional radiation hydrodynamical simulations to solve accretion flows onto massive black holes (BHs) with a very high rate. Assuming that photon trapping limits the luminosity emerging from the central region to L≲LEdd, Inayoshi, Haiman & Ostriker (2016) have shown that an accretion flow settles to a \"hyper-Eddington\" solution, with a steady and isothermal (T≃8000 K) Bondi profile reaching ≳5000 times the Eddington accretion rate M˙Edd≡LEdd/c2. Here we address the possibility that gas accreting with finite angular momentum forms a bright nuclear accretion disc, with a luminosity exceeding the Eddington limit (1≲L/LEdd≲100). Combining our simulations with an analytic model, we find that a transition to steady hyper-Eddington accretion still occurs, as long as the luminosity remains below L/LEdd≲35 (MBH/10^4 M⊙)^3/2(n∞/10^5 cm^−3)(T∞/10^4 K)^−3/2(r⋆/10^14 cm)^−1/2, where n∞ and T∞ are the density and temperature of the ambient gas, and r⋆ is the radius of the photosphere, at which radiation emerges. If the luminosity exceeds this value, accretion becomes episodic. Our results can be accurately recovered in a toy model of an optically thick spherical shell, driven by radiation force into a collapsing medium. When the central source is dimmer than the above critical value, the expansion of the shell is halted and reversed by ram pressure of the collapsing medium, and by shell's weight. Our results imply that rapid, unimpeded hyper-Eddington accretion is possible even if the luminosity of the central source far exceeds the Eddington limit, and can be either steady or strongly episodic."}],"page":"4496-4504","doi":"10.1093/mnras/stw1652","main_file_link":[{"url":"https://doi.org/10.1093/mnras/stw1652","open_access":"1"}],"issue":"4","citation":{"short":"Y. Sakurai, K. Inayoshi, Z. Haiman, Monthly Notices of the Royal Astronomical Society 461 (2016) 4496–4504.","ista":"Sakurai Y, Inayoshi K, Haiman Z. 2016. Hyper-Eddington mass accretion on to a black hole with super-Eddington luminosity. Monthly Notices of the Royal Astronomical Society. 461(4), 4496–4504.","apa":"Sakurai, Y., Inayoshi, K., &#38; Haiman, Z. (2016). Hyper-Eddington mass accretion on to a black hole with super-Eddington luminosity. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stw1652\">https://doi.org/10.1093/mnras/stw1652</a>","ama":"Sakurai Y, Inayoshi K, Haiman Z. Hyper-Eddington mass accretion on to a black hole with super-Eddington luminosity. <i>Monthly Notices of the Royal Astronomical Society</i>. 2016;461(4):4496-4504. doi:<a href=\"https://doi.org/10.1093/mnras/stw1652\">10.1093/mnras/stw1652</a>","mla":"Sakurai, Yuya, et al. “Hyper-Eddington Mass Accretion on to a Black Hole with Super-Eddington Luminosity.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 461, no. 4, Oxford University Press, 2016, pp. 4496–504, doi:<a href=\"https://doi.org/10.1093/mnras/stw1652\">10.1093/mnras/stw1652</a>.","chicago":"Sakurai, Yuya, Kohei Inayoshi, and Zoltán Haiman. “Hyper-Eddington Mass Accretion on to a Black Hole with Super-Eddington Luminosity.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2016. <a href=\"https://doi.org/10.1093/mnras/stw1652\">https://doi.org/10.1093/mnras/stw1652</a>.","ieee":"Y. Sakurai, K. Inayoshi, and Z. Haiman, “Hyper-Eddington mass accretion on to a black hole with super-Eddington luminosity,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 461, no. 4. Oxford University Press, pp. 4496–4504, 2016."},"quality_controlled":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","type":"journal_article","article_type":"original","status":"public","date_published":"2016-07-08T00:00:00Z","month":"07","author":[{"last_name":"Sakurai","first_name":"Yuya","full_name":"Sakurai, Yuya"},{"full_name":"Inayoshi, Kohei","last_name":"Inayoshi","first_name":"Kohei"},{"full_name":"Haiman, Zoltán","id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","last_name":"Haiman","first_name":"Zoltán"}],"intvolume":"       461","date_updated":"2024-09-25T10:02:57Z","oa":1,"extern":"1","publication_status":"published","publication":"Monthly Notices of the Royal Astronomical Society","title":"Hyper-Eddington mass accretion on to a black hole with super-Eddington luminosity","article_processing_charge":"No","year":"2016","day":"08","volume":461,"publication_identifier":{"issn":["0035-8711","1365-2966"]},"date_created":"2024-09-06T08:39:53Z","language":[{"iso":"eng"}]},{"oa_version":"Published Version","_id":"17699","scopus_import":"1","publisher":"Oxford University Press","extern":"1","abstract":[{"lang":"eng","text":"We quantify the presence of Ly\\alpha\\ damping wing absorption from a partially-neutral intergalactic medium (IGM) in the spectrum of the z=7.08 QSO, ULASJ1120+0641. Using a Bayesian framework, we simultaneously account for uncertainties in: (i) the intrinsic QSO emission spectrum; and (ii) the distribution of cosmic HI patches during the epoch of reionisation (EoR). For (i) we use a new intrinsic Ly\\alpha\\ emission line reconstruction method (Greig et al.), sampling a covariance matrix of emission line properties built from a large database of moderate-z QSOs. For (ii), we use the Evolution of 21-cm Structure (EOS; Mesinger et al.) simulations, which span a range of physically-motivated EoR models. We find strong evidence for the presence of damping wing absorption redward of Ly\\alpha\\ (where there is no contamination from the Ly\\alpha\\ forest). Our analysis implies that the EoR is not yet complete by z=7.1, with the volume-weighted IGM neutral fraction constrained to x¯HI=0.40+0.21−0.19 at 1σ (x¯HI=0.40+0.41−0.32 at 2σ). This result is insensitive to the EoR morphology. Our detection of significant neutral HI in the IGM at z=7.1 is consistent with the latest Planck 2016 measurements of the CMB Thompson scattering optical depth (Planck Collaboration XLVII)."}],"doi":"10.1093/mnras/stw3351","citation":{"chicago":"Greig, Bradley, Andrei Mesinger, Zoltán Haiman, and Robert A. Simcoe. “Are We Witnessing the Epoch of Reionization at Z=7.1 from the Spectrum of J1120+0641?” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2016. <a href=\"https://doi.org/10.1093/mnras/stw3351\">https://doi.org/10.1093/mnras/stw3351</a>.","mla":"Greig, Bradley, et al. “Are We Witnessing the Epoch of Reionization at Z=7.1 from the Spectrum of J1120+0641?” <i>Monthly Notices of the Royal Astronomical Society</i>, stw3351, Oxford University Press, 2016, doi:<a href=\"https://doi.org/10.1093/mnras/stw3351\">10.1093/mnras/stw3351</a>.","ama":"Greig B, Mesinger A, Haiman Z, Simcoe RA. Are we witnessing the epoch of reionization at z=7.1 from the spectrum of J1120+0641? <i>Monthly Notices of the Royal Astronomical Society</i>. 2016. doi:<a href=\"https://doi.org/10.1093/mnras/stw3351\">10.1093/mnras/stw3351</a>","ieee":"B. Greig, A. Mesinger, Z. Haiman, and R. A. Simcoe, “Are we witnessing the epoch of reionization at z=7.1 from the spectrum of J1120+0641?,” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2016.","ista":"Greig B, Mesinger A, Haiman Z, Simcoe RA. 2016. Are we witnessing the epoch of reionization at z=7.1 from the spectrum of J1120+0641? Monthly Notices of the Royal Astronomical Society., stw3351.","short":"B. Greig, A. Mesinger, Z. Haiman, R.A. Simcoe, Monthly Notices of the Royal Astronomical Society (2016).","apa":"Greig, B., Mesinger, A., Haiman, Z., &#38; Simcoe, R. A. (2016). Are we witnessing the epoch of reionization at z=7.1 from the spectrum of J1120+0641? <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stw3351\">https://doi.org/10.1093/mnras/stw3351</a>"},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1093/mnras/stw3351"}],"publication_status":"published","publication":"Monthly Notices of the Royal Astronomical Society","quality_controlled":"1","article_processing_charge":"No","title":"Are we witnessing the epoch of reionization at z=7.1 from the spectrum of J1120+0641?","type":"journal_article","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_number":"stw3351","day":"24","year":"2016","status":"public","article_type":"original","author":[{"full_name":"Greig, Bradley","first_name":"Bradley","last_name":"Greig"},{"last_name":"Mesinger","first_name":"Andrei","full_name":"Mesinger, Andrei"},{"id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","full_name":"Haiman, Zoltán","first_name":"Zoltán","last_name":"Haiman"},{"full_name":"Simcoe, Robert A.","first_name":"Robert A.","last_name":"Simcoe"}],"date_published":"2016-12-24T00:00:00Z","month":"12","publication_identifier":{"issn":["0035-8711","1365-2966"]},"date_created":"2024-09-06T08:45:10Z","language":[{"iso":"eng"}],"oa":1,"date_updated":"2024-09-25T11:19:08Z"},{"date_created":"2024-09-06T08:46:28Z","language":[{"iso":"eng"}],"volume":460,"publication_identifier":{"issn":["0035-8711","1365-2966"]},"day":"24","year":"2016","publication":"Monthly Notices of the Royal Astronomical Society","article_processing_charge":"No","title":"Intermediate-mass black holes from Population III remnants in the first galactic nuclei","publication_status":"published","extern":"1","intvolume":"       460","oa":1,"date_updated":"2024-09-25T11:22:16Z","author":[{"last_name":"Ryu","first_name":"Taeho","full_name":"Ryu, Taeho"},{"full_name":"Tanaka, Takamitsu L.","last_name":"Tanaka","first_name":"Takamitsu L."},{"full_name":"Perna, Rosalba","first_name":"Rosalba","last_name":"Perna"},{"first_name":"Zoltán","last_name":"Haiman","id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","full_name":"Haiman, Zoltán"}],"month":"05","date_published":"2016-05-24T00:00:00Z","type":"journal_article","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_type":"original","status":"public","quality_controlled":"1","doi":"10.1093/mnras/stw1241","citation":{"ieee":"T. Ryu, T. L. Tanaka, R. Perna, and Z. Haiman, “Intermediate-mass black holes from Population III remnants in the first galactic nuclei,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 460, no. 4. Oxford University Press, pp. 4122–4134, 2016.","ama":"Ryu T, Tanaka TL, Perna R, Haiman Z. Intermediate-mass black holes from Population III remnants in the first galactic nuclei. <i>Monthly Notices of the Royal Astronomical Society</i>. 2016;460(4):4122-4134. doi:<a href=\"https://doi.org/10.1093/mnras/stw1241\">10.1093/mnras/stw1241</a>","chicago":"Ryu, Taeho, Takamitsu L. Tanaka, Rosalba Perna, and Zoltán Haiman. “Intermediate-Mass Black Holes from Population III Remnants in the First Galactic Nuclei.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2016. <a href=\"https://doi.org/10.1093/mnras/stw1241\">https://doi.org/10.1093/mnras/stw1241</a>.","mla":"Ryu, Taeho, et al. “Intermediate-Mass Black Holes from Population III Remnants in the First Galactic Nuclei.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 460, no. 4, Oxford University Press, 2016, pp. 4122–34, doi:<a href=\"https://doi.org/10.1093/mnras/stw1241\">10.1093/mnras/stw1241</a>.","apa":"Ryu, T., Tanaka, T. L., Perna, R., &#38; Haiman, Z. (2016). Intermediate-mass black holes from Population III remnants in the first galactic nuclei. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stw1241\">https://doi.org/10.1093/mnras/stw1241</a>","ista":"Ryu T, Tanaka TL, Perna R, Haiman Z. 2016. Intermediate-mass black holes from Population III remnants in the first galactic nuclei. Monthly Notices of the Royal Astronomical Society. 460(4), 4122–4134.","short":"T. Ryu, T.L. Tanaka, R. Perna, Z. Haiman, Monthly Notices of the Royal Astronomical Society 460 (2016) 4122–4134."},"issue":"4","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1093/mnras/stw1241"}],"publisher":"Oxford University Press","page":"4122-4134","abstract":[{"lang":"eng","text":"We report the formation of intermediate-mass black holes (IMBHs) in suites of numerical N-body simulations of Population III remnant black holes (BHs) embedded in gas-rich protogalaxies at redshifts z≳10. We model the effects of gas drag on the BHs' orbits, and allow BHs to grow via gas accretion, including a mode of hyper-Eddington accretion in which photon trapping and rapid gas inflow suppress any negative radiative feedback. Most initial BH configurations lead to the formation of one (but never more than one) IMBH in the center of the protogalaxy, reaching a mass of 10^3−5M⊙ through hyper-Eddington growth. Our results suggest a viable pathway to forming the earliest massive BHs in the centers of early galaxies. We also find that the nuclear IMBH typically captures a stellar-mass BH companion, making these systems observable in gravitational waves as extreme mass-ratio inspirals (EMRIs) with eLISA."}],"oa_version":"Published Version","_id":"17700","scopus_import":"1"},{"publication":"Monthly Notices of the Royal Astronomical Society","article_processing_charge":"No","title":"Hyper-Eddington accretion flows on to massive black holes","publication_status":"published","extern":"1","date_created":"2024-09-06T08:54:12Z","language":[{"iso":"eng"}],"volume":459,"publication_identifier":{"issn":["0035-8711","1365-2966"]},"day":"12","year":"2016","quality_controlled":"1","doi":"10.1093/mnras/stw836","citation":{"apa":"Inayoshi, K., Haiman, Z., &#38; Ostriker, J. P. (2016). Hyper-Eddington accretion flows on to massive black holes. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stw836\">https://doi.org/10.1093/mnras/stw836</a>","ista":"Inayoshi K, Haiman Z, Ostriker JP. 2016. Hyper-Eddington accretion flows on to massive black holes. Monthly Notices of the Royal Astronomical Society. 459(4), 3738–3755.","short":"K. Inayoshi, Z. Haiman, J.P. Ostriker, Monthly Notices of the Royal Astronomical Society 459 (2016) 3738–3755.","ieee":"K. Inayoshi, Z. Haiman, and J. P. Ostriker, “Hyper-Eddington accretion flows on to massive black holes,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 459, no. 4. Oxford University Press, pp. 3738–3755, 2016.","ama":"Inayoshi K, Haiman Z, Ostriker JP. Hyper-Eddington accretion flows on to massive black holes. <i>Monthly Notices of the Royal Astronomical Society</i>. 2016;459(4):3738-3755. doi:<a href=\"https://doi.org/10.1093/mnras/stw836\">10.1093/mnras/stw836</a>","chicago":"Inayoshi, Kohei, Zoltán Haiman, and Jeremiah P. Ostriker. “Hyper-Eddington Accretion Flows on to Massive Black Holes.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2016. <a href=\"https://doi.org/10.1093/mnras/stw836\">https://doi.org/10.1093/mnras/stw836</a>.","mla":"Inayoshi, Kohei, et al. “Hyper-Eddington Accretion Flows on to Massive Black Holes.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 459, no. 4, Oxford University Press, 2016, pp. 3738–55, doi:<a href=\"https://doi.org/10.1093/mnras/stw836\">10.1093/mnras/stw836</a>."},"issue":"4","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1093/mnras/stw836"}],"publisher":"Oxford University Press","page":"3738-3755","abstract":[{"lang":"eng","text":"We study very-high rate spherically symmetric accretion flows onto a massive black hole (BH; 10^2 < M_BH < 10^6 Msun) embedded in a dense gas cloud with a low abundance of metals, performing one-dimensional hydrodynamical simulations which include multi-frequency radiation transfer and non-equilibrium primordial chemistry. We find that rapid gas supply from the Bondi radius at a hyper-Eddington rate can occur without being impeded by radiation feedback when (n/10^5 cm^-3) > (M_BH/10^4Msun)^{-1}(T/10^4 K)^{3/2}, where n and T are the density and temperature of ambient gas outside of the Bondi radius. The resulting accretion rate in this regime is steady, and larger than 3000 times the Eddington rate. At lower Bondi rates, the accretion is episodic due to radiative feedback and the average rate is limited below the Eddington rate. For the hyper-Eddington case, the steady solution consists of two parts: a radiation-dominated central core, where photon trapping due to electron scattering is important, and an accreting envelope which follows a Bondi profile with T~8000 K. When the emergent luminosity is limited below the Eddington luminosity because of photon trapping, radiation from the central region does not affect the gas dynamics at larger scales. We apply our result to the rapid formation of massive BHs in protogalaxies with a virial temperature of T_vir> 10^4 K. Once a seed BH forms at the center of the galaxy, it can grow up to a maximum ~10^5 (T_vir/10^4 K) Msun via gas accretion independent of the initial BH mass. Finally, we discuss possible observational signatures of rapidly accreting BHs with/without allowance for dust. We suggest that these systems could explain Lya emitters without X-rays and luminous infrared sources with hot dust emission, respectively."}],"oa_version":"Published Version","_id":"17709","scopus_import":"1","intvolume":"       459","date_updated":"2024-09-25T12:00:22Z","oa":1,"author":[{"first_name":"Kohei","last_name":"Inayoshi","full_name":"Inayoshi, Kohei"},{"first_name":"Zoltán","last_name":"Haiman","id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","full_name":"Haiman, Zoltán"},{"last_name":"Ostriker","first_name":"Jeremiah P.","full_name":"Ostriker, Jeremiah P."}],"month":"04","date_published":"2016-04-12T00:00:00Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","type":"journal_article","status":"public","article_type":"original"},{"volume":48,"publication_identifier":{"issn":["1061-4036","1546-1718"]},"day":"28","year":"2016","date_created":"2020-04-30T10:50:26Z","language":[{"iso":"eng"}],"extern":"1","publication":"Nature Genetics","article_processing_charge":"No","title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","publication_status":"published","author":[{"last_name":"Zhu","first_name":"Zhihong","full_name":"Zhu, Zhihong"},{"full_name":"Zhang, Futao","last_name":"Zhang","first_name":"Futao"},{"full_name":"Hu, Han","first_name":"Han","last_name":"Hu"},{"last_name":"Bakshi","first_name":"Andrew","full_name":"Bakshi, Andrew"},{"id":"E5D42276-F5DA-11E9-8E24-6303E6697425","orcid":"0000-0001-8982-8813","full_name":"Robinson, Matthew Richard","first_name":"Matthew Richard","last_name":"Robinson"},{"first_name":"Joseph E","last_name":"Powell","full_name":"Powell, Joseph E"},{"full_name":"Montgomery, Grant W","last_name":"Montgomery","first_name":"Grant W"},{"first_name":"Michael E","last_name":"Goddard","full_name":"Goddard, Michael E"},{"full_name":"Wray, Naomi R","first_name":"Naomi R","last_name":"Wray"},{"full_name":"Visscher, Peter M","first_name":"Peter M","last_name":"Visscher"},{"first_name":"Jian","last_name":"Yang","full_name":"Yang, Jian"}],"month":"03","date_published":"2016-03-28T00:00:00Z","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","status":"public","intvolume":"        48","date_updated":"2021-01-12T08:15:11Z","oa":1,"publisher":"Springer Nature","page":"481-487","abstract":[{"lang":"eng","text":"Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with human complex traits. However, the genes or functional DNA elements through which these variants exert their effects on the traits are often unknown. We propose a method (called SMR) that integrates summary-level data from GWAS with data from expression quantitative trait locus (eQTL) studies to identify genes whose expression levels are associated with a complex trait because of pleiotropy. We apply the method to five human complex traits using GWAS data on up to 339,224 individuals and eQTL data on 5,311 individuals, and we prioritize 126 genes (for example, TRAF1 and ANKRD55 for rheumatoid arthritis and SNX19 and NMRAL1 for schizophrenia), of which 25 genes are new candidates; 77 genes are not the nearest annotated gene to the top associated GWAS SNP. These genes provide important leads to design future functional studies to understand the mechanism whereby DNA variation leads to complex trait variation."}],"oa_version":"Published Version","_id":"7737","quality_controlled":"1","doi":"10.1038/ng.3538","citation":{"short":"Z. Zhu, F. Zhang, H. Hu, A. Bakshi, M.R. Robinson, J.E. Powell, G.W. Montgomery, M.E. Goddard, N.R. Wray, P.M. Visscher, J. Yang, Nature Genetics 48 (2016) 481–487.","ista":"Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, Montgomery GW, Goddard ME, Wray NR, Visscher PM, Yang J. 2016. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nature Genetics. 48(5), 481–487.","apa":"Zhu, Z., Zhang, F., Hu, H., Bakshi, A., Robinson, M. R., Powell, J. E., … Yang, J. (2016). Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. <i>Nature Genetics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/ng.3538\">https://doi.org/10.1038/ng.3538</a>","mla":"Zhu, Zhihong, et al. “Integration of Summary Data from GWAS and EQTL Studies Predicts Complex Trait Gene Targets.” <i>Nature Genetics</i>, vol. 48, no. 5, Springer Nature, 2016, pp. 481–87, doi:<a href=\"https://doi.org/10.1038/ng.3538\">10.1038/ng.3538</a>.","chicago":"Zhu, Zhihong, Futao Zhang, Han Hu, Andrew Bakshi, Matthew Richard Robinson, Joseph E Powell, Grant W Montgomery, et al. “Integration of Summary Data from GWAS and EQTL Studies Predicts Complex Trait Gene Targets.” <i>Nature Genetics</i>. Springer Nature, 2016. <a href=\"https://doi.org/10.1038/ng.3538\">https://doi.org/10.1038/ng.3538</a>.","ama":"Zhu Z, Zhang F, Hu H, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. <i>Nature Genetics</i>. 2016;48(5):481-487. doi:<a href=\"https://doi.org/10.1038/ng.3538\">10.1038/ng.3538</a>","ieee":"Z. Zhu <i>et al.</i>, “Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets,” <i>Nature Genetics</i>, vol. 48, no. 5. Springer Nature, pp. 481–487, 2016."},"issue":"5","main_file_link":[{"url":"https://doi.org/10.1038/ng.3538","open_access":"1"}]},{"doi":"10.1145/2903136","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1311.3200"}],"issue":"4","citation":{"short":"D.-A. Alistarh, K. Censor Hillel, N. Shavit, Journal of the ACM 63 (2016).","ista":"Alistarh D-A, Censor Hillel K, Shavit N. 2016. Are lock free concurrent algorithms practically wait free . Journal of the ACM. 63(4).","apa":"Alistarh, D.-A., Censor Hillel, K., &#38; Shavit, N. (2016). Are lock free concurrent algorithms practically wait free . <i>Journal of the ACM</i>. ACM. <a href=\"https://doi.org/10.1145/2903136\">https://doi.org/10.1145/2903136</a>","ama":"Alistarh D-A, Censor Hillel K, Shavit N. Are lock free concurrent algorithms practically wait free . <i>Journal of the ACM</i>. 2016;63(4). doi:<a href=\"https://doi.org/10.1145/2903136\">10.1145/2903136</a>","chicago":"Alistarh, Dan-Adrian, Keren Censor Hillel, and Nir Shavit. “Are Lock Free Concurrent Algorithms Practically Wait Free .” <i>Journal of the ACM</i>. ACM, 2016. <a href=\"https://doi.org/10.1145/2903136\">https://doi.org/10.1145/2903136</a>.","mla":"Alistarh, Dan-Adrian, et al. “Are Lock Free Concurrent Algorithms Practically Wait Free .” <i>Journal of the ACM</i>, vol. 63, no. 4, ACM, 2016, doi:<a href=\"https://doi.org/10.1145/2903136\">10.1145/2903136</a>.","ieee":"D.-A. Alistarh, K. Censor Hillel, and N. Shavit, “Are lock free concurrent algorithms practically wait free ,” <i>Journal of the ACM</i>, vol. 63, no. 4. ACM, 2016."},"quality_controlled":"1","oa_version":"Preprint","_id":"786","publisher":"ACM","abstract":[{"lang":"eng","text":"Lock-free concurrent algorithms guarantee that some concurrent operation will always make progress in a finite number of steps. Yet programmers prefer to treat concurrent code as if it were wait-free, guaranteeing that all operations always make progress. Unfortunately, designing wait-free algorithms is generally a very complex task, and the resulting algorithms are not always efficient. Although obtaining efficient wait-free algorithms has been a long-time goal for the theory community, most nonblocking commercial code is only lock-free. This article suggests a simple solution to this problem.We show that for a large class of lock-free algorithms, under scheduling conditions that approximate those found in commercial hardware architectures, lock-free algorithms behave as if they are wait-free. In other words, programmers can continue to design simple lock-free algorithms instead of complex wait-free ones, and in practice, they will get wait-free progress. Our main contribution is a new way of analyzing a general class of lock-free algorithms under a stochastic scheduler. Our analysis relates the individual performance of processes to the global performance of the system using Markov chain lifting between a complex per-process chain and a simpler system progress chain. We show that lock-free algorithms are not only wait-free with probability 1 but that in fact a general subset of lock-free algorithms can be closely bounded in terms of the average number of steps required until an operation completes. To the best of our knowledge, this is the first attempt to analyze progress conditions, typically stated in relation to a worst-case adversary, in a stochastic model capturing their expected asymptotic behavior."}],"external_id":{"arxiv":["1311.3200"]},"intvolume":"        63","arxiv":1,"oa":1,"date_updated":"2023-02-23T13:19:04Z","publist_id":"6870","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","status":"public","date_published":"2016-09-01T00:00:00Z","month":"09","author":[{"full_name":"Alistarh, Dan-Adrian","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-3650-940X","last_name":"Alistarh","first_name":"Dan-Adrian"},{"last_name":"Censor Hillel","first_name":"Keren","full_name":"Censor Hillel, Keren"},{"full_name":"Shavit, Nir","last_name":"Shavit","first_name":"Nir"}],"publication_status":"published","publication":"Journal of the ACM","acknowledgement":"Part of this work was performed while the first author was a postdoctoral associate at MIT CSAIL, where he was supported by the SNF Postdoctoral Fellows Program, NSF grant CCF-1217921, DoE ASCR grant ER26116/DE-SC0008923, and by grants from the Oracle and Intel corporations. The second author was supported in part by ISF grant 1696/14. The third author was supported in part by NSF grants CCF-1217921, CCF-1301926, IIS-1447786, and CCF-1561807, and the U.S. Department of Energy under grant DE-SC0008923, and by equipment grants from Intel Corporation.","title":"Are lock free concurrent algorithms practically wait free ","article_processing_charge":"No","extern":"1","date_created":"2018-12-11T11:48:29Z","language":[{"iso":"eng"}],"year":"2016","day":"01","volume":63},{"intvolume":"        90","date_updated":"2021-01-12T08:16:34Z","oa":1,"month":"04","date_published":"2016-04-06T00:00:00Z","author":[{"full_name":"Barron, H.C.","last_name":"Barron","first_name":"H.C."},{"id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","orcid":"0000-0003-3295-6181","full_name":"Vogels, Tim P","first_name":"Tim P","last_name":"Vogels"},{"last_name":"Emir","first_name":"U.E.","full_name":"Emir, U.E."},{"full_name":"Makin, T.R.","last_name":"Makin","first_name":"T.R."},{"first_name":"J.","last_name":"O’Shea","full_name":"O’Shea, J."},{"full_name":"Clare, S.","first_name":"S.","last_name":"Clare"},{"full_name":"Jbabdi, S.","last_name":"Jbabdi","first_name":"S."},{"first_name":"R.J.","last_name":"Dolan","full_name":"Dolan, R.J."},{"full_name":"Behrens, T.E.J.","last_name":"Behrens","first_name":"T.E.J."}],"type":"journal_article","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","article_type":"original","status":"public","quality_controlled":"1","pmid":1,"doi":"10.1016/j.neuron.2016.02.031","issue":"1","citation":{"short":"H.C. Barron, T.P. Vogels, U.E. Emir, T.R. Makin, J. O’Shea, S. Clare, S. Jbabdi, R.J. Dolan, T.E.J. Behrens, Neuron 90 (2016) 191–203.","ista":"Barron HC, Vogels TP, Emir UE, Makin TR, O’Shea J, Clare S, Jbabdi S, Dolan RJ, Behrens TEJ. 2016. Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories. Neuron. 90(1), 191–203.","apa":"Barron, H. C., Vogels, T. P., Emir, U. E., Makin, T. R., O’Shea, J., Clare, S., … Behrens, T. E. J. (2016). Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2016.02.031\">https://doi.org/10.1016/j.neuron.2016.02.031</a>","ama":"Barron HC, Vogels TP, Emir UE, et al. Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories. <i>Neuron</i>. 2016;90(1):191-203. doi:<a href=\"https://doi.org/10.1016/j.neuron.2016.02.031\">10.1016/j.neuron.2016.02.031</a>","chicago":"Barron, H.C., Tim P Vogels, U.E. Emir, T.R. Makin, J. O’Shea, S. Clare, S. Jbabdi, R.J. Dolan, and T.E.J. Behrens. “Unmasking Latent Inhibitory Connections in Human Cortex to Reveal Dormant Cortical Memories.” <i>Neuron</i>. Elsevier, 2016. <a href=\"https://doi.org/10.1016/j.neuron.2016.02.031\">https://doi.org/10.1016/j.neuron.2016.02.031</a>.","mla":"Barron, H. C., et al. “Unmasking Latent Inhibitory Connections in Human Cortex to Reveal Dormant Cortical Memories.” <i>Neuron</i>, vol. 90, no. 1, Elsevier, 2016, pp. 191–203, doi:<a href=\"https://doi.org/10.1016/j.neuron.2016.02.031\">10.1016/j.neuron.2016.02.031</a>.","ieee":"H. C. Barron <i>et al.</i>, “Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories,” <i>Neuron</i>, vol. 90, no. 1. Elsevier, pp. 191–203, 2016."},"publisher":"Elsevier","abstract":[{"text":"Balance of cortical excitation and inhibition (EI) is thought to be disrupted in several neuropsychiatric conditions, yet it is not clear how it is maintained in the healthy human brain. When EI balance is disturbed during learning and memory in animal models, it can be restabilized via formation of inhibitory replicas of newly formed excitatory connections. Here we assess evidence for such selective inhibitory rebalancing in humans. Using fMRI repetition suppression we measure newly formed cortical associations in the human brain. We show that expression of these associations reduces over time despite persistence in behavior, consistent with inhibitory rebalancing. To test this, we modulated excitation/inhibition balance with transcranial direct current stimulation (tDCS). Using ultra-high-field (7T) MRI and spectroscopy, we show that reducing GABA allows cortical associations to be re-expressed. This suggests that in humans associative memories are stored in balanced excitatory-inhibitory ensembles that lie dormant unless latent inhibitory connections are unmasked.","lang":"eng"}],"external_id":{"pmid":["26996082"]},"page":"191-203","_id":"8020","oa_version":"Published Version","has_accepted_license":"1","date_created":"2020-06-25T13:05:33Z","ddc":["570"],"language":[{"iso":"eng"}],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"file":[{"checksum":"9ce7a1c64986dce0435c070285a7ef9b","creator":"cziletti","file_name":"2016_Neuron_Barron.pdf","file_size":5334136,"relation":"main_file","date_updated":"2020-07-14T12:48:08Z","date_created":"2020-07-09T09:57:04Z","access_level":"open_access","file_id":"8104","content_type":"application/pdf"}],"file_date_updated":"2020-07-14T12:48:08Z","volume":90,"publication_identifier":{"issn":["0896-6273"]},"year":"2016","day":"06","publication":"Neuron","title":"Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories","article_processing_charge":"No","publication_status":"published","extern":"1"},{"quality_controlled":"1","doi":"10.7551/978-0-262-33936-0-ch029","citation":{"ista":"Martius GS, Hostettler R, Knoll A, Der R. 2016. Self-organized control of an tendon driven arm by differential extrinsic plasticity. 15th International Conference on the Synthesis and Simulation of Living Systems. ALIFE 2016: Conference on the Synthesis and Simulation of Living Systems vol. 28, 142–143.","short":"G.S. Martius, R. Hostettler, A. Knoll, R. Der, in:, 15th International Conference on the Synthesis and Simulation of Living Systems, MIT Press, 2016, pp. 142–143.","apa":"Martius, G. S., Hostettler, R., Knoll, A., &#38; Der, R. (2016). Self-organized control of an tendon driven arm by differential extrinsic plasticity. In <i>15th International Conference on the Synthesis and Simulation of Living Systems</i> (Vol. 28, pp. 142–143). Cancun, Mexico: MIT Press. <a href=\"https://doi.org/10.7551/978-0-262-33936-0-ch029\">https://doi.org/10.7551/978-0-262-33936-0-ch029</a>","ama":"Martius GS, Hostettler R, Knoll A, Der R. Self-organized control of an tendon driven arm by differential extrinsic plasticity. In: <i>15th International Conference on the Synthesis and Simulation of Living Systems</i>. Vol 28. MIT Press; 2016:142-143. doi:<a href=\"https://doi.org/10.7551/978-0-262-33936-0-ch029\">10.7551/978-0-262-33936-0-ch029</a>","chicago":"Martius, Georg S, Rafael Hostettler, Alois Knoll, and Ralf Der. “Self-Organized Control of an Tendon Driven Arm by Differential Extrinsic Plasticity.” In <i>15th International Conference on the Synthesis and Simulation of Living Systems</i>, 28:142–43. MIT Press, 2016. <a href=\"https://doi.org/10.7551/978-0-262-33936-0-ch029\">https://doi.org/10.7551/978-0-262-33936-0-ch029</a>.","mla":"Martius, Georg S., et al. “Self-Organized Control of an Tendon Driven Arm by Differential Extrinsic Plasticity.” <i>15th International Conference on the Synthesis and Simulation of Living Systems</i>, vol. 28, MIT Press, 2016, pp. 142–43, doi:<a href=\"https://doi.org/10.7551/978-0-262-33936-0-ch029\">10.7551/978-0-262-33936-0-ch029</a>.","ieee":"G. S. Martius, R. Hostettler, A. Knoll, and R. Der, “Self-organized control of an tendon driven arm by differential extrinsic plasticity,” in <i>15th International Conference on the Synthesis and Simulation of Living Systems</i>, Cancun, Mexico, 2016, vol. 28, pp. 142–143."},"publisher":"MIT Press","page":"142-143","abstract":[{"text":"With the accelerated development of robot technologies, optimal control becomes one of the central themes of research. In traditional approaches, the controller, by its internal functionality, finds appropriate actions on the basis of the history of sensor values, guided by the goals, intentions, objectives, learning schemes, and so forth. The idea is that the controller controls the world---the body plus its environment---as reliably as possible. This paper focuses on new lines of self-organization for developmental robotics. We apply the recently developed differential extrinsic synaptic plasticity to a muscle-tendon driven arm-shoulder system from the Myorobotics toolkit. In the experiments, we observe a vast variety of self-organized behavior patterns: when left alone, the arm realizes pseudo-random sequences of different poses. By applying physical forces, the system can be entrained into definite motion patterns like wiping a table. Most interestingly, after attaching an object, the controller gets in a functional resonance with the object's internal dynamics, starting to shake spontaneously bottles half-filled with water or sensitively driving an attached pendulum into a circular mode. When attached to the crank of a wheel the neural system independently discovers how to rotate it. In this way, the robot discovers affordances of objects its body is interacting with.","lang":"eng"}],"_id":"8094","oa_version":"Published Version","scopus_import":"1","has_accepted_license":"1","department":[{"_id":"ChLa"},{"_id":"GaTk"}],"intvolume":"        28","date_updated":"2025-07-10T11:55:05Z","oa":1,"project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","grant_number":"291734"}],"author":[{"first_name":"Georg S","last_name":"Martius","id":"3A276B68-F248-11E8-B48F-1D18A9856A87","full_name":"Martius, Georg S"},{"full_name":"Hostettler, Rafael","first_name":"Rafael","last_name":"Hostettler"},{"last_name":"Knoll","first_name":"Alois","full_name":"Knoll, Alois"},{"full_name":"Der, Ralf","last_name":"Der","first_name":"Ralf"}],"month":"09","date_published":"2016-09-01T00:00:00Z","type":"conference","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","publication":"15th International Conference on the Synthesis and Simulation of Living Systems","article_processing_charge":"No","title":"Self-organized control of an tendon driven arm by differential extrinsic plasticity","corr_author":"1","publication_status":"published","ec_funded":1,"date_created":"2020-07-05T22:00:47Z","ddc":["610"],"language":[{"iso":"eng"}],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"file":[{"checksum":"cff63e7a4b8ac466ba51a9c84153a940","creator":"cziletti","file_size":678670,"relation":"main_file","file_name":"2016_ProcALIFE_Martius.pdf","access_level":"open_access","date_created":"2020-07-06T12:59:09Z","date_updated":"2020-07-14T12:48:09Z","content_type":"application/pdf","file_id":"8096"}],"volume":28,"publication_identifier":{"isbn":["9780262339360"]},"file_date_updated":"2020-07-14T12:48:09Z","day":"01","year":"2016","conference":{"start_date":"2016-07-04","end_date":"2016-07-08","location":"Cancun, Mexico","name":"ALIFE 2016: Conference on the Synthesis and Simulation of Living Systems"}},{"author":[{"full_name":"Clopath, Claudia","last_name":"Clopath","first_name":"Claudia"},{"orcid":"0000-0003-3295-6181","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","full_name":"Vogels, Tim P","first_name":"Tim P","last_name":"Vogels"},{"first_name":"Robert C.","last_name":"Froemke","full_name":"Froemke, Robert C."},{"full_name":"Sprekeler, Henning","first_name":"Henning","last_name":"Sprekeler"}],"date_published":"2016-07-29T00:00:00Z","month":"07","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","day":"29","type":"preprint","year":"2016","status":"public","date_created":"2020-07-16T12:26:55Z","language":[{"iso":"eng"}],"oa":1,"date_updated":"2021-01-12T08:17:02Z","publisher":"Cold Spring Harbor Laboratory","extern":"1","page":"43","abstract":[{"lang":"eng","text":"The stimulus selectivity of synaptic currents in cortical neurons often shows a co-tuning of excitation and inhibition, but the mechanisms that underlie the emergence and plasticity of this co-tuning are not fully understood. Using a computational model, we show that an interaction of excitatory and inhibitory synaptic plasticity reproduces both the developmental and – when combined with a disinhibitory gate – the adult plasticity of excitatory and inhibitory receptive fields in auditory cortex. The co-tuning arises from inhibitory plasticity that balances excitation and inhibition, while excitatory stimulus selectivity can result from two different mechanisms. Inhibitory inputs with a broad stimulus tuning introduce a sliding threshold as in Bienenstock-Cooper-Munro rules, introducing an excitatory stimulus selectivity at the cost of a broader inhibitory receptive field. Alternatively, input asymmetries can be amplified by synaptic competition. The latter leaves any receptive field plasticity transient, a prediction we verify in recordings in auditory cortex."}],"_id":"8128","oa_version":"Preprint","publication":"bioRxiv","article_processing_charge":"No","title":"Receptive field formation by interacting excitatory and inhibitory synaptic plasticity","citation":{"ieee":"C. Clopath, T. P. Vogels, R. C. Froemke, and H. Sprekeler, “Receptive field formation by interacting excitatory and inhibitory synaptic plasticity,” <i>bioRxiv</i>. Cold Spring Harbor Laboratory, 2016.","chicago":"Clopath, Claudia, Tim P Vogels, Robert C. Froemke, and Henning Sprekeler. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” <i>BioRxiv</i>. Cold Spring Harbor Laboratory, 2016.","mla":"Clopath, Claudia, et al. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” <i>BioRxiv</i>, Cold Spring Harbor Laboratory, 2016.","ama":"Clopath C, Vogels TP, Froemke RC, Sprekeler H. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. <i>bioRxiv</i>. 2016.","apa":"Clopath, C., Vogels, T. P., Froemke, R. C., &#38; Sprekeler, H. (2016). Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. <i>bioRxiv</i>. Cold Spring Harbor Laboratory.","short":"C. Clopath, T.P. Vogels, R.C. Froemke, H. Sprekeler, BioRxiv (2016).","ista":"Clopath C, Vogels TP, Froemke RC, Sprekeler H. 2016. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. bioRxiv, ."},"publication_status":"published","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/066589 "}]},{"extern":"1","publication_status":"published","publication":"OncoImmunology","article_processing_charge":"No","title":"Proof of concept study with an HER-2 mimotope anticancer vaccine deduced from a novel AAV-mimotope library platform","article_number":"e1171446","day":"30","year":"2016","volume":5,"publication_identifier":{"issn":["2162-402X"]},"date_created":"2020-08-10T11:54:03Z","language":[{"iso":"eng"}],"oa_version":"Published Version","_id":"8241","publisher":"Taylor & Francis","abstract":[{"lang":"eng","text":"Background: Anticancer vaccines could represent a valuable complementary strategy to established therapies, especially in settings of early stage and minimal residual disease. HER-2 is an important target for immunotherapy and addressed by the monoclonal antibody trastuzumab. We have previously generated HER-2 mimotope peptides from phage display libraries. The synthesized peptides were coupled to carriers and applied for epitope-specific induction of trastuzumab-like IgG. For simplification and to avoid methodological limitations of synthesis and coupling chemistry, we herewith present a novel and optimized approach by using adeno-associated viruses (AAV) as effective and high-density mimotope-display system, which can be directly used for vaccination. Methods: An AAV capsid display library was constructed by genetically incorporating random peptides in a plasmid encoding the wild-type AAV2 capsid protein. AAV clones, expressing peptides specifically reactive to trastuzumab, were employed to immunize BALB/c mice. Antibody titers against human HER-2 were determined, and the isotype composition and functional properties of these were tested. Finally, prophylactically immunized mice were challenged with human HER-2 transfected mouse D2F2/E2 cells. Results: HER-2 mimotope AAV-vaccines induced antibodies specific to human HER-2. Two clones were selected for immunization of mice, which were subsequently grafted D2F2/E2 cells. Both mimotope AAV clones delayed the growth of tumors significantly, as compared to controls. Conclusion: In this study, a novel mimotope AAV-based platform was created allowing the isolation of mimotopes, which can be directly used as anticancer vaccines. The example of trastuzumab AAV-mimotopes demonstrates that this vaccine strategy could help to establish active immunotherapy for breast-cancer patients."}],"doi":"10.1080/2162402x.2016.1171446","citation":{"apa":"Singer, J., Manzano-Szalai, K., Singer, J., Thell, K., Bentley-Lukschal, A., Stremnitzer, C., … Jensen-Jarolim, E. (2016). Proof of concept study with an HER-2 mimotope anticancer vaccine deduced from a novel AAV-mimotope library platform. <i>OncoImmunology</i>. Taylor &#38; Francis. <a href=\"https://doi.org/10.1080/2162402x.2016.1171446\">https://doi.org/10.1080/2162402x.2016.1171446</a>","short":"J. Singer, K. Manzano-Szalai, J. Singer, K. Thell, A. Bentley-Lukschal, C. Stremnitzer, F. Roth-Walter, M. Weghofer, M. Ritter, K. Pino Tossi, M. Hörer, U. Michaelis, E. Jensen-Jarolim, OncoImmunology 5 (2016).","ista":"Singer J, Manzano-Szalai K, Singer J, Thell K, Bentley-Lukschal A, Stremnitzer C, Roth-Walter F, Weghofer M, Ritter M, Pino Tossi K, Hörer M, Michaelis U, Jensen-Jarolim E. 2016. Proof of concept study with an HER-2 mimotope anticancer vaccine deduced from a novel AAV-mimotope library platform. OncoImmunology. 5(7), e1171446.","ieee":"J. Singer <i>et al.</i>, “Proof of concept study with an HER-2 mimotope anticancer vaccine deduced from a novel AAV-mimotope library platform,” <i>OncoImmunology</i>, vol. 5, no. 7. Taylor &#38; Francis, 2016.","mla":"Singer, Josef, et al. “Proof of Concept Study with an HER-2 Mimotope Anticancer Vaccine Deduced from a Novel AAV-Mimotope Library Platform.” <i>OncoImmunology</i>, vol. 5, no. 7, e1171446, Taylor &#38; Francis, 2016, doi:<a href=\"https://doi.org/10.1080/2162402x.2016.1171446\">10.1080/2162402x.2016.1171446</a>.","chicago":"Singer, Josef, Krisztina Manzano-Szalai, Judit Singer, Kathrin Thell, Anna Bentley-Lukschal, Caroline Stremnitzer, Franziska Roth-Walter, et al. “Proof of Concept Study with an HER-2 Mimotope Anticancer Vaccine Deduced from a Novel AAV-Mimotope Library Platform.” <i>OncoImmunology</i>. Taylor &#38; Francis, 2016. <a href=\"https://doi.org/10.1080/2162402x.2016.1171446\">https://doi.org/10.1080/2162402x.2016.1171446</a>.","ama":"Singer J, Manzano-Szalai K, Singer J, et al. Proof of concept study with an HER-2 mimotope anticancer vaccine deduced from a novel AAV-mimotope library platform. <i>OncoImmunology</i>. 2016;5(7). doi:<a href=\"https://doi.org/10.1080/2162402x.2016.1171446\">10.1080/2162402x.2016.1171446</a>"},"issue":"7","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1080/2162402X.2016.1171446"}],"quality_controlled":"1","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","article_type":"original","author":[{"first_name":"Josef","last_name":"Singer","full_name":"Singer, Josef"},{"full_name":"Manzano-Szalai, Krisztina","first_name":"Krisztina","last_name":"Manzano-Szalai"},{"first_name":"Judit","last_name":"Fazekas","id":"36432834-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8777-3502","full_name":"Fazekas, Judit"},{"full_name":"Thell, Kathrin","last_name":"Thell","first_name":"Kathrin"},{"full_name":"Bentley-Lukschal, Anna","last_name":"Bentley-Lukschal","first_name":"Anna"},{"full_name":"Stremnitzer, Caroline","last_name":"Stremnitzer","first_name":"Caroline"},{"full_name":"Roth-Walter, Franziska","last_name":"Roth-Walter","first_name":"Franziska"},{"last_name":"Weghofer","first_name":"Margit","full_name":"Weghofer, Margit"},{"last_name":"Ritter","first_name":"Mirko","full_name":"Ritter, Mirko"},{"first_name":"Kerstin","last_name":"Pino Tossi","full_name":"Pino Tossi, Kerstin"},{"last_name":"Hörer","first_name":"Markus","full_name":"Hörer, Markus"},{"first_name":"Uwe","last_name":"Michaelis","full_name":"Michaelis, Uwe"},{"full_name":"Jensen-Jarolim, Erika","first_name":"Erika","last_name":"Jensen-Jarolim"}],"month":"06","date_published":"2016-06-30T00:00:00Z","intvolume":"         5","oa":1,"date_updated":"2021-01-12T08:17:41Z"},{"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1602.06997"}],"publication_status":"published","citation":{"mla":"Kokoris Kogias, Eleftherios, et al. “Enhancing Bitcoin Security and Performance with Strong Consistency via Collective Signing.” <i>Proceedings of the 25th USENIX Conference on Security Symposium</i>, USENIX Association, 2016, pp. 279–296.","chicago":"Kokoris Kogias, Eleftherios, Philipp Jovanovic, Nicolas Gailly, Ismail Khoffi, Linus Gasser, and Bryan Ford. “Enhancing Bitcoin Security and Performance with Strong Consistency via Collective Signing.” In <i>Proceedings of the 25th USENIX Conference on Security Symposium</i>, 279–296. USENIX Association, 2016.","ama":"Kokoris Kogias E, Jovanovic P, Gailly N, Khoffi I, Gasser L, Ford B. Enhancing bitcoin security and performance with strong consistency via collective signing. In: <i>Proceedings of the 25th USENIX Conference on Security Symposium</i>. USENIX Association; 2016:279–296.","ieee":"E. Kokoris Kogias, P. Jovanovic, N. Gailly, I. Khoffi, L. Gasser, and B. Ford, “Enhancing bitcoin security and performance with strong consistency via collective signing,” in <i>Proceedings of the 25th USENIX Conference on Security Symposium</i>, Austin, TX, United States, 2016, pp. 279–296.","short":"E. Kokoris Kogias, P. Jovanovic, N. Gailly, I. Khoffi, L. Gasser, B. Ford, in:, Proceedings of the 25th USENIX Conference on Security Symposium, USENIX Association, 2016, pp. 279–296.","ista":"Kokoris Kogias E, Jovanovic P, Gailly N, Khoffi I, Gasser L, Ford B. 2016. Enhancing bitcoin security and performance with strong consistency via collective signing. Proceedings of the 25th USENIX Conference on Security Symposium. SEC: Security Symposium, 279–296.","apa":"Kokoris Kogias, E., Jovanovic, P., Gailly, N., Khoffi, I., Gasser, L., &#38; Ford, B. (2016). Enhancing bitcoin security and performance with strong consistency via collective signing. In <i>Proceedings of the 25th USENIX Conference on Security Symposium</i> (pp. 279–296). Austin, TX, United States: USENIX Association."},"title":"Enhancing bitcoin security and performance with strong consistency via collective signing","article_processing_charge":"No","quality_controlled":"1","publication":"Proceedings of the 25th USENIX Conference on Security Symposium","_id":"8302","oa_version":"Published Version","abstract":[{"lang":"eng","text":"While showing great promise, Bitcoin requires users to wait tens of minutes for transactions to commit, and even then, offering only probabilistic guarantees. This paper introduces ByzCoin, a novel Byzantine consensus protocol that leverages scalable collective signing to commit Bitcoin transactions irreversibly within seconds. ByzCoin achieves Byzantine consensus while preserving Bitcoin’s open membership by dynamically forming hash power-proportionate consensus groups that represent recently-successful block miners. ByzCoin employs communication trees to optimize transaction commitment and verification under normal operation while guaranteeing safety and liveness under Byzantine faults, up to a near-optimal tolerance of f faulty group members among 3f + 2 total. ByzCoin mitigates double spending and selfish mining attacks by producing collectively signed transaction blocks within one minute of transaction submission. Tree-structured communication further reduces this latency to less than 30 seconds. Due to these optimizations, ByzCoin achieves a throughput higher than Paypal currently handles, with a confirmation latency of 15-20 seconds."}],"external_id":{"arxiv":["1602.06997"]},"page":"279–296","extern":"1","publisher":"USENIX Association","date_updated":"2021-01-12T08:18:00Z","oa":1,"language":[{"iso":"eng"}],"date_created":"2020-08-26T12:08:35Z","arxiv":1,"status":"public","conference":{"end_date":"2016-08-12","start_date":"2016-08-10","location":"Austin, TX, United States","name":"SEC: Security Symposium"},"year":"2016","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"01","type":"conference","publication_identifier":{"isbn":["9781931971324"]},"date_published":"2016-09-01T00:00:00Z","month":"09","author":[{"full_name":"Kokoris Kogias, Eleftherios","id":"f5983044-d7ef-11ea-ac6d-fd1430a26d30","last_name":"Kokoris Kogias","first_name":"Eleftherios"},{"first_name":"Philipp","last_name":"Jovanovic","full_name":"Jovanovic, Philipp"},{"full_name":"Gailly, Nicolas","last_name":"Gailly","first_name":"Nicolas"},{"last_name":"Khoffi","first_name":"Ismail","full_name":"Khoffi, Ismail"},{"full_name":"Gasser, Linus","first_name":"Linus","last_name":"Gasser"},{"first_name":"Bryan","last_name":"Ford","full_name":"Ford, Bryan"}]},{"quality_controlled":"1","issue":"1-2","citation":{"apa":"Bakail, M. M., &#38; Ochsenbein, F. (2016). Targeting protein–protein interactions, a wide open field for drug design. <i>Comptes Rendus Chimie</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.crci.2015.12.004\">https://doi.org/10.1016/j.crci.2015.12.004</a>","ista":"Bakail MM, Ochsenbein F. 2016. Targeting protein–protein interactions, a wide open field for drug design. Comptes Rendus Chimie. 19(1–2), 19–27.","short":"M.M. Bakail, F. Ochsenbein, Comptes Rendus Chimie 19 (2016) 19–27.","ieee":"M. M. Bakail and F. Ochsenbein, “Targeting protein–protein interactions, a wide open field for drug design,” <i>Comptes Rendus Chimie</i>, vol. 19, no. 1–2. Elsevier, pp. 19–27, 2016.","ama":"Bakail MM, Ochsenbein F. Targeting protein–protein interactions, a wide open field for drug design. <i>Comptes Rendus Chimie</i>. 2016;19(1-2):19-27. doi:<a href=\"https://doi.org/10.1016/j.crci.2015.12.004\">10.1016/j.crci.2015.12.004</a>","chicago":"Bakail, May M, and Francoise Ochsenbein. “Targeting Protein–Protein Interactions, a Wide Open Field for Drug Design.” <i>Comptes Rendus Chimie</i>. Elsevier, 2016. <a href=\"https://doi.org/10.1016/j.crci.2015.12.004\">https://doi.org/10.1016/j.crci.2015.12.004</a>.","mla":"Bakail, May M., and Francoise Ochsenbein. “Targeting Protein–Protein Interactions, a Wide Open Field for Drug Design.” <i>Comptes Rendus Chimie</i>, vol. 19, no. 1–2, Elsevier, 2016, pp. 19–27, doi:<a href=\"https://doi.org/10.1016/j.crci.2015.12.004\">10.1016/j.crci.2015.12.004</a>."},"doi":"10.1016/j.crci.2015.12.004","keyword":["General Chemistry","General Chemical Engineering"],"abstract":[{"text":"Targeting protein–protein interactions has long been considered as a very difficult if impossible task, but over the past decade, front lines have moved. The number of successful examples is exponentially growing. This review presents a rapid overview of recent advances in this field considering the strengths and weaknesses of the small molecule approaches and alternative strategies such as the selection or design of artificial antibodies, peptides or peptidomimetics.","lang":"eng"},{"lang":"fre","text":"Cibler les interactions protéine–protéine a longtemps été considéré comme une tâche très difficile, voire impossible, mais, depuis les dix dernières années, les lignes ont bougé. Le nombre d’exemples de réussites s’accroît exponentiellement. Cette revue présente un rapide panorama des avancées récentes dans ce domaine, considérant les forces et les faiblesses de l’approche « petite molécule » ainsi que des stratégies alternatives comme la sélection ou le design d’anticorps artificiels, de peptides ou de peptidomimétiques."}],"page":"19-27","publisher":"Elsevier","has_accepted_license":"1","_id":"9019","oa_version":"Published Version","oa":1,"date_updated":"2023-02-23T13:46:55Z","intvolume":"        19","month":"02","date_published":"2016-02-06T00:00:00Z","author":[{"id":"FB3C3F8E-522F-11EA-B186-22963DDC885E","orcid":"0000-0002-9592-1587","full_name":"Bakail, May M","first_name":"May M","last_name":"Bakail"},{"full_name":"Ochsenbein, Francoise","first_name":"Francoise","last_name":"Ochsenbein"}],"article_type":"original","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","title":"Targeting protein–protein interactions, a wide open field for drug design","article_processing_charge":"No","publication":"Comptes Rendus Chimie","publication_status":"published","extern":"1","language":[{"iso":"eng"}],"ddc":["570"],"date_created":"2021-01-19T11:11:54Z","file":[{"file_size":2045260,"relation":"main_file","file_name":"2016_ComptesRendueChimie_Bakail.pdf","checksum":"c262814ffdbfe95900256ab9ff42cdf5","creator":"dernst","content_type":"application/pdf","success":1,"file_id":"9035","date_created":"2021-01-22T12:36:52Z","access_level":"open_access","date_updated":"2021-01-22T12:36:52Z"}],"tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"file_date_updated":"2021-01-22T12:36:52Z","publication_identifier":{"issn":["1631-0748"]},"volume":19,"year":"2016","day":"06"},{"publication_status":"published","publication":"Soft Matter","title":"Dynamic self-assembly of microscale rotors and swimmers","article_processing_charge":"No","extern":"1","date_created":"2021-02-01T13:44:00Z","language":[{"iso":"eng"}],"year":"2016","day":"28","publication_identifier":{"issn":["1744-683X"],"eissn":["1744-6848"]},"volume":12,"pmid":1,"doi":"10.1039/c5sm03127c","issue":"20","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1509.06330"}],"citation":{"ieee":"M. S. Davies Wykes <i>et al.</i>, “Dynamic self-assembly of microscale rotors and swimmers,” <i>Soft Matter</i>, vol. 12, no. 20. Royal Society of Chemistry, pp. 4584–4589, 2016.","ama":"Davies Wykes MS, Palacci JA, Adachi T, et al. Dynamic self-assembly of microscale rotors and swimmers. <i>Soft Matter</i>. 2016;12(20):4584-4589. doi:<a href=\"https://doi.org/10.1039/c5sm03127c\">10.1039/c5sm03127c</a>","chicago":"Davies Wykes, Megan S., Jérémie A Palacci, Takuji Adachi, Leif Ristroph, Xiao Zhong, Michael D. Ward, Jun Zhang, and Michael J. Shelley. “Dynamic Self-Assembly of Microscale Rotors and Swimmers.” <i>Soft Matter</i>. Royal Society of Chemistry, 2016. <a href=\"https://doi.org/10.1039/c5sm03127c\">https://doi.org/10.1039/c5sm03127c</a>.","mla":"Davies Wykes, Megan S., et al. “Dynamic Self-Assembly of Microscale Rotors and Swimmers.” <i>Soft Matter</i>, vol. 12, no. 20, Royal Society of Chemistry, 2016, pp. 4584–89, doi:<a href=\"https://doi.org/10.1039/c5sm03127c\">10.1039/c5sm03127c</a>.","apa":"Davies Wykes, M. S., Palacci, J. A., Adachi, T., Ristroph, L., Zhong, X., Ward, M. D., … Shelley, M. J. (2016). Dynamic self-assembly of microscale rotors and swimmers. <i>Soft Matter</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/c5sm03127c\">https://doi.org/10.1039/c5sm03127c</a>","short":"M.S. Davies Wykes, J.A. Palacci, T. Adachi, L. Ristroph, X. Zhong, M.D. Ward, J. Zhang, M.J. Shelley, Soft Matter 12 (2016) 4584–4589.","ista":"Davies Wykes MS, Palacci JA, Adachi T, Ristroph L, Zhong X, Ward MD, Zhang J, Shelley MJ. 2016. Dynamic self-assembly of microscale rotors and swimmers. Soft Matter. 12(20), 4584–4589."},"quality_controlled":"1","_id":"9051","oa_version":"Preprint","scopus_import":"1","publisher":"Royal Society of Chemistry","abstract":[{"text":"Biological systems often involve the self-assembly of basic components into complex and functioning structures. Artificial systems that mimic such processes can provide a well-controlled setting to explore the principles involved and also synthesize useful micromachines. Our experiments show that immotile, but active, components self-assemble into two types of structure that exhibit the fundamental forms of motility: translation and rotation. Specifically, micron-scale metallic rods are designed to induce extensile surface flows in the presence of a chemical fuel; these rods interact with each other and pair up to form either a swimmer or a rotor. Such pairs can transition reversibly between these two configurations, leading to kinetics reminiscent of bacterial run-and-tumble motion.","lang":"eng"}],"external_id":{"arxiv":["1509.06330"],"pmid":["27121100"]},"page":"4584-4589","intvolume":"        12","arxiv":1,"date_updated":"2023-02-23T13:47:38Z","oa":1,"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","type":"journal_article","article_type":"original","status":"public","month":"05","date_published":"2016-05-28T00:00:00Z","author":[{"full_name":"Davies Wykes, Megan S.","last_name":"Davies Wykes","first_name":"Megan S."},{"first_name":"Jérémie A","last_name":"Palacci","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","orcid":"0000-0002-7253-9465","full_name":"Palacci, Jérémie A"},{"full_name":"Adachi, Takuji","first_name":"Takuji","last_name":"Adachi"},{"last_name":"Ristroph","first_name":"Leif","full_name":"Ristroph, Leif"},{"full_name":"Zhong, Xiao","first_name":"Xiao","last_name":"Zhong"},{"full_name":"Ward, Michael D.","first_name":"Michael D.","last_name":"Ward"},{"full_name":"Zhang, Jun","first_name":"Jun","last_name":"Zhang"},{"full_name":"Shelley, Michael J.","last_name":"Shelley","first_name":"Michael J."}]},{"quality_controlled":"1","pmid":1,"keyword":["General Chemistry","Condensed Matter Physics"],"doi":"10.1039/c6sm01163b","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1609.01497"}],"issue":"30","citation":{"apa":"Moyses, H., Palacci, J. A., Sacanna, S., &#38; Grier, D. G. (2016). Trochoidal trajectories of self-propelled Janus particles in a diverging laser beam. <i>Soft Matter</i>. Royal Society of Chemistry . <a href=\"https://doi.org/10.1039/c6sm01163b\">https://doi.org/10.1039/c6sm01163b</a>","ista":"Moyses H, Palacci JA, Sacanna S, Grier DG. 2016. Trochoidal trajectories of self-propelled Janus particles in a diverging laser beam. Soft Matter. 12(30), 6357–6364.","short":"H. Moyses, J.A. Palacci, S. Sacanna, D.G. Grier, Soft Matter 12 (2016) 6357–6364.","ieee":"H. Moyses, J. A. Palacci, S. Sacanna, and D. G. Grier, “Trochoidal trajectories of self-propelled Janus particles in a diverging laser beam,” <i>Soft Matter</i>, vol. 12, no. 30. Royal Society of Chemistry , pp. 6357–6364, 2016.","chicago":"Moyses, Henrique, Jérémie A Palacci, Stefano Sacanna, and David G. Grier. “Trochoidal Trajectories of Self-Propelled Janus Particles in a Diverging Laser Beam.” <i>Soft Matter</i>. Royal Society of Chemistry , 2016. <a href=\"https://doi.org/10.1039/c6sm01163b\">https://doi.org/10.1039/c6sm01163b</a>.","mla":"Moyses, Henrique, et al. “Trochoidal Trajectories of Self-Propelled Janus Particles in a Diverging Laser Beam.” <i>Soft Matter</i>, vol. 12, no. 30, Royal Society of Chemistry , 2016, pp. 6357–64, doi:<a href=\"https://doi.org/10.1039/c6sm01163b\">10.1039/c6sm01163b</a>.","ama":"Moyses H, Palacci JA, Sacanna S, Grier DG. Trochoidal trajectories of self-propelled Janus particles in a diverging laser beam. <i>Soft Matter</i>. 2016;12(30):6357-6364. doi:<a href=\"https://doi.org/10.1039/c6sm01163b\">10.1039/c6sm01163b</a>"},"publisher":"Royal Society of Chemistry ","abstract":[{"lang":"eng","text":"We describe colloidal Janus particles with metallic and dielectric faces that swim vigorously when illuminated by defocused optical tweezers without consuming any chemical fuel. Rather than wandering randomly, these optically-activated colloidal swimmers circulate back and forth through the beam of light, tracing out sinuous rosette patterns. We propose a model for this mode of light-activated transport that accounts for the observed behavior through a combination of self-thermophoresis and optically-induced torque. In the deterministic limit, this model yields trajectories that resemble rosette curves known as hypotrochoids."}],"page":"6357-6364","external_id":{"arxiv":["1609.01497"],"pmid":["27338294"]},"_id":"9052","oa_version":"Preprint","scopus_import":"1","intvolume":"        12","arxiv":1,"oa":1,"date_updated":"2023-02-23T13:47:40Z","date_published":"2016-08-14T00:00:00Z","month":"08","author":[{"last_name":"Moyses","first_name":"Henrique","full_name":"Moyses, Henrique"},{"last_name":"Palacci","first_name":"Jérémie A","full_name":"Palacci, Jérémie A","orcid":"0000-0002-7253-9465","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d"},{"full_name":"Sacanna, Stefano","first_name":"Stefano","last_name":"Sacanna"},{"full_name":"Grier, David G.","last_name":"Grier","first_name":"David G."}],"type":"journal_article","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","status":"public","article_type":"original","publication":"Soft Matter","title":"Trochoidal trajectories of self-propelled Janus particles in a diverging laser beam","article_processing_charge":"No","publication_status":"published","extern":"1","date_created":"2021-02-01T13:44:15Z","language":[{"iso":"eng"}],"publication_identifier":{"issn":["1744-683X"],"eissn":["1744-6848"]},"volume":12,"year":"2016","day":"14"},{"volume":121,"publication_identifier":{"issn":["2169-897X","2169-8996"]},"day":"16","year":"2016","language":[{"iso":"eng"}],"date_created":"2021-02-15T14:21:16Z","extern":"1","article_processing_charge":"No","title":"Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape?","publication":"Journal of Geophysical Research: Atmospheres","publication_status":"published","author":[{"last_name":"Drobinski","first_name":"P.","full_name":"Drobinski, P."},{"first_name":"B.","last_name":"Alonzo","full_name":"Alonzo, B."},{"full_name":"Bastin, S.","last_name":"Bastin","first_name":"S."},{"last_name":"Silva","first_name":"N. Da","full_name":"Silva, N. Da"},{"first_name":"Caroline J","last_name":"Muller","id":"f978ccb0-3f7f-11eb-b193-b0e2bd13182b","orcid":"0000-0001-5836-5350","full_name":"Muller, Caroline J"}],"date_published":"2016-03-16T00:00:00Z","month":"03","article_type":"original","status":"public","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","type":"journal_article","oa":1,"date_updated":"2022-01-24T13:41:02Z","intvolume":"       121","page":"3100-3119","abstract":[{"lang":"eng","text":"Expected changes to future extreme precipitation remain a key uncertainty associated with anthropogenic climate change. Extreme precipitation has been proposed to scale with the precipitable water content in the atmosphere. Assuming constant relative humidity, this implies an increase of precipitation extremes at a rate of about 7% °C−1 globally as indicated by the Clausius‐Clapeyron relationship. Increases faster and slower than Clausius‐Clapeyron have also been reported. In this work, we examine the scaling between precipitation extremes and temperature in the present climate using simulations and measurements from surface weather stations collected in the frame of the HyMeX and MED‐CORDEX programs in Southern France. Of particular interest are departures from the Clausius‐Clapeyron thermodynamic expectation, their spatial and temporal distribution, and their origin. Looking at the scaling of precipitation extreme with temperature, two regimes emerge which form a hook shape: one at low temperatures (cooler than around 15°C) with rates of increase close to the Clausius‐Clapeyron rate and one at high temperatures (warmer than about 15°C) with sub‐Clausius‐Clapeyron rates and most often negative rates. On average, the region of focus does not seem to exhibit super Clausius‐Clapeyron behavior except at some stations, in contrast to earlier studies. Many factors can contribute to departure from Clausius‐Clapeyron scaling: time and spatial averaging, choice of scaling temperature (surface versus condensation level), and precipitation efficiency and vertical velocity in updrafts that are not necessarily constant with temperature. But most importantly, the dynamical contribution of orography to precipitation in the fall over this area during the so‐called “Cevenoles” events, explains the hook shape of the scaling of precipitation extremes."}],"publisher":"American Geophysical Union","_id":"9140","oa_version":"Published Version","quality_controlled":"1","citation":{"ieee":"P. Drobinski, B. Alonzo, S. Bastin, N. D. Silva, and C. J. Muller, “Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape?,” <i>Journal of Geophysical Research: Atmospheres</i>, vol. 121, no. 7. American Geophysical Union, pp. 3100–3119, 2016.","chicago":"Drobinski, P., B. Alonzo, S. Bastin, N. Da Silva, and Caroline J Muller. “Scaling of Precipitation Extremes with Temperature in the French Mediterranean Region: What Explains the Hook Shape?” <i>Journal of Geophysical Research: Atmospheres</i>. American Geophysical Union, 2016. <a href=\"https://doi.org/10.1002/2015jd023497\">https://doi.org/10.1002/2015jd023497</a>.","mla":"Drobinski, P., et al. “Scaling of Precipitation Extremes with Temperature in the French Mediterranean Region: What Explains the Hook Shape?” <i>Journal of Geophysical Research: Atmospheres</i>, vol. 121, no. 7, American Geophysical Union, 2016, pp. 3100–19, doi:<a href=\"https://doi.org/10.1002/2015jd023497\">10.1002/2015jd023497</a>.","ama":"Drobinski P, Alonzo B, Bastin S, Silva ND, Muller CJ. Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape? <i>Journal of Geophysical Research: Atmospheres</i>. 2016;121(7):3100-3119. doi:<a href=\"https://doi.org/10.1002/2015jd023497\">10.1002/2015jd023497</a>","apa":"Drobinski, P., Alonzo, B., Bastin, S., Silva, N. D., &#38; Muller, C. J. (2016). Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape? <i>Journal of Geophysical Research: Atmospheres</i>. American Geophysical Union. <a href=\"https://doi.org/10.1002/2015jd023497\">https://doi.org/10.1002/2015jd023497</a>","short":"P. Drobinski, B. Alonzo, S. Bastin, N.D. Silva, C.J. Muller, Journal of Geophysical Research: Atmospheres 121 (2016) 3100–3119.","ista":"Drobinski P, Alonzo B, Bastin S, Silva ND, Muller CJ. 2016. Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape? Journal of Geophysical Research: Atmospheres. 121(7), 3100–3119."},"issue":"7","main_file_link":[{"url":"https://doi.org/10.1002/2015JD023497","open_access":"1"}],"doi":"10.1002/2015jd023497"},{"language":[{"iso":"eng"}],"date_created":"2021-06-04T11:34:55Z","year":"2016","day":"27","volume":538,"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"publication_status":"published","title":"Mechanism for DNA transposons to generate introns on genomic scales","article_processing_charge":"No","publication":"Nature","extern":"1","date_updated":"2021-12-14T07:55:30Z","oa":1,"intvolume":"       538","department":[{"_id":"DaZi"}],"article_type":"letter_note","status":"public","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","type":"journal_article","date_published":"2016-10-27T00:00:00Z","month":"10","author":[{"full_name":"Huff, Jason T.","first_name":"Jason T.","last_name":"Huff"},{"full_name":"Zilberman, Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","orcid":"0000-0002-0123-8649","last_name":"Zilberman","first_name":"Daniel"},{"full_name":"Roy, Scott W.","last_name":"Roy","first_name":"Scott W."}],"issue":"7626","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684705/"}],"citation":{"short":"J.T. Huff, D. Zilberman, S.W. Roy, Nature 538 (2016) 533–536.","ista":"Huff JT, Zilberman D, Roy SW. 2016. Mechanism for DNA transposons to generate introns on genomic scales. Nature. 538(7626), 533–536.","apa":"Huff, J. T., Zilberman, D., &#38; Roy, S. W. (2016). Mechanism for DNA transposons to generate introns on genomic scales. <i>Nature</i>. Springer Nature . <a href=\"https://doi.org/10.1038/nature20110\">https://doi.org/10.1038/nature20110</a>","ama":"Huff JT, Zilberman D, Roy SW. Mechanism for DNA transposons to generate introns on genomic scales. <i>Nature</i>. 2016;538(7626):533-536. doi:<a href=\"https://doi.org/10.1038/nature20110\">10.1038/nature20110</a>","mla":"Huff, Jason T., et al. “Mechanism for DNA Transposons to Generate Introns on Genomic Scales.” <i>Nature</i>, vol. 538, no. 7626, Springer Nature , 2016, pp. 533–36, doi:<a href=\"https://doi.org/10.1038/nature20110\">10.1038/nature20110</a>.","chicago":"Huff, Jason T., Daniel Zilberman, and Scott W. Roy. “Mechanism for DNA Transposons to Generate Introns on Genomic Scales.” <i>Nature</i>. Springer Nature , 2016. <a href=\"https://doi.org/10.1038/nature20110\">https://doi.org/10.1038/nature20110</a>.","ieee":"J. T. Huff, D. Zilberman, and S. W. Roy, “Mechanism for DNA transposons to generate introns on genomic scales,” <i>Nature</i>, vol. 538, no. 7626. Springer Nature , pp. 533–536, 2016."},"pmid":1,"doi":"10.1038/nature20110","quality_controlled":"1","scopus_import":"1","_id":"9456","oa_version":"Submitted Version","abstract":[{"lang":"eng","text":"The discovery of introns four decades ago was one of the most unexpected findings in molecular biology. Introns are sequences interrupting genes that must be removed as part of messenger RNA production. Genome sequencing projects have shown that most eukaryotic genes contain at least one intron, and frequently many. Comparison of these genomes reveals a history of long evolutionary periods during which few introns were gained, punctuated by episodes of rapid, extensive gain. However, although several detailed mechanisms for such episodic intron generation have been proposed, none has been empirically supported on a genomic scale. Here we show how short, non-autonomous DNA transposons independently generated hundreds to thousands of introns in the prasinophyte Micromonas pusilla and the pelagophyte Aureococcus anophagefferens. Each transposon carries one splice site. The other splice site is co-opted from the gene sequence that is duplicated upon transposon insertion, allowing perfect splicing out of the RNA. The distributions of sequences that can be co-opted are biased with respect to codons, and phasing of transposon-generated introns is similarly biased. These transposons insert between pre-existing nucleosomes, so that multiple nearby insertions generate nucleosome-sized intervening segments. Thus, transposon insertion and sequence co-option may explain the intron phase biases and prevalence of nucleosome-sized exons observed in eukaryotes. Overall, the two independent examples of proliferating elements illustrate a general DNA transposon mechanism that can plausibly account for episodes of rapid, extensive intron gain during eukaryotic evolution."}],"page":"533-536","external_id":{"pmid":["27760113"]},"publisher":"Springer Nature "},{"year":"2016","day":"27","volume":113,"publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"date_created":"2021-06-07T06:21:39Z","language":[{"iso":"eng"}],"extern":"1","publication_status":"published","publication":"Proceedings of the National Academy of Sciences","title":"Arabidopsis male sexual lineage exhibits more robust maintenance of CG methylation than somatic tissues","article_processing_charge":"No","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","article_type":"original","month":"12","date_published":"2016-12-27T00:00:00Z","author":[{"first_name":"Ping-Hung","last_name":"Hsieh","full_name":"Hsieh, Ping-Hung"},{"full_name":"He, Shengbo","last_name":"He","first_name":"Shengbo"},{"full_name":"Buttress, Toby","first_name":"Toby","last_name":"Buttress"},{"full_name":"Gao, Hongbo","first_name":"Hongbo","last_name":"Gao"},{"full_name":"Couchman, Matthew","last_name":"Couchman","first_name":"Matthew"},{"full_name":"Fischer, Robert L.","first_name":"Robert L.","last_name":"Fischer"},{"last_name":"Zilberman","first_name":"Daniel","full_name":"Zilberman, Daniel","orcid":"0000-0002-0123-8649","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1"},{"last_name":"Feng","first_name":"Xiaoqi","full_name":"Feng, Xiaoqi","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","orcid":"0000-0002-4008-1234"}],"intvolume":"       113","department":[{"_id":"DaZi"},{"_id":"XiFe"}],"date_updated":"2023-05-08T11:00:40Z","oa":1,"_id":"9473","oa_version":"Published Version","scopus_import":"1","publisher":"National Academy of Sciences","abstract":[{"lang":"eng","text":"Cytosine DNA methylation regulates the expression of eukaryotic genes and transposons. Methylation is copied by methyltransferases after DNA replication, which results in faithful transmission of methylation patterns during cell division and, at least in flowering plants, across generations. Transgenerational inheritance is mediated by a small group of cells that includes gametes and their progenitors. However, methylation is usually analyzed in somatic tissues that do not contribute to the next generation, and the mechanisms of transgenerational inheritance are inferred from such studies. To gain a better understanding of how DNA methylation is inherited, we analyzed purified Arabidopsis thaliana sperm and vegetative cells-the cell types that comprise pollen-with mutations in the DRM, CMT2, and CMT3 methyltransferases. We find that DNA methylation dependency on these enzymes is similar in sperm, vegetative cells, and somatic tissues, although DRM activity extends into heterochromatin in vegetative cells, likely reflecting transcription of heterochromatic transposons in this cell type. We also show that lack of histone H1, which elevates heterochromatic DNA methylation in somatic tissues, does not have this effect in pollen. Instead, levels of CG methylation in wild-type sperm and vegetative cells, as well as in wild-type microspores from which both pollen cell types originate, are substantially higher than in wild-type somatic tissues and similar to those of H1-depleted roots. Our results demonstrate that the mechanisms of methylation maintenance are similar between pollen and somatic cells, but the efficiency of CG methylation is higher in pollen, allowing methylation patterns to be accurately inherited across generations."}],"external_id":{"pmid":["27956643"]},"page":"15132-15137","pmid":1,"doi":"10.1073/pnas.1619074114","issue":"52","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1073/pnas.1619074114"}],"citation":{"ama":"Hsieh P-H, He S, Buttress T, et al. Arabidopsis male sexual lineage exhibits more robust maintenance of CG methylation than somatic tissues. <i>Proceedings of the National Academy of Sciences</i>. 2016;113(52):15132-15137. doi:<a href=\"https://doi.org/10.1073/pnas.1619074114\">10.1073/pnas.1619074114</a>","mla":"Hsieh, Ping-Hung, et al. “Arabidopsis Male Sexual Lineage Exhibits More Robust Maintenance of CG Methylation than Somatic Tissues.” <i>Proceedings of the National Academy of Sciences</i>, vol. 113, no. 52, National Academy of Sciences, 2016, pp. 15132–37, doi:<a href=\"https://doi.org/10.1073/pnas.1619074114\">10.1073/pnas.1619074114</a>.","chicago":"Hsieh, Ping-Hung, Shengbo He, Toby Buttress, Hongbo Gao, Matthew Couchman, Robert L. Fischer, Daniel Zilberman, and Xiaoqi Feng. “Arabidopsis Male Sexual Lineage Exhibits More Robust Maintenance of CG Methylation than Somatic Tissues.” <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences, 2016. <a href=\"https://doi.org/10.1073/pnas.1619074114\">https://doi.org/10.1073/pnas.1619074114</a>.","ieee":"P.-H. Hsieh <i>et al.</i>, “Arabidopsis male sexual lineage exhibits more robust maintenance of CG methylation than somatic tissues,” <i>Proceedings of the National Academy of Sciences</i>, vol. 113, no. 52. National Academy of Sciences, pp. 15132–15137, 2016.","short":"P.-H. Hsieh, S. He, T. Buttress, H. Gao, M. Couchman, R.L. Fischer, D. Zilberman, X. Feng, Proceedings of the National Academy of Sciences 113 (2016) 15132–15137.","ista":"Hsieh P-H, He S, Buttress T, Gao H, Couchman M, Fischer RL, Zilberman D, Feng X. 2016. Arabidopsis male sexual lineage exhibits more robust maintenance of CG methylation than somatic tissues. Proceedings of the National Academy of Sciences. 113(52), 15132–15137.","apa":"Hsieh, P.-H., He, S., Buttress, T., Gao, H., Couchman, M., Fischer, R. L., … Feng, X. (2016). Arabidopsis male sexual lineage exhibits more robust maintenance of CG methylation than somatic tissues. <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1619074114\">https://doi.org/10.1073/pnas.1619074114</a>"},"quality_controlled":"1"},{"year":"2016","day":"27","publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"volume":113,"language":[{"iso":"eng"}],"date_created":"2021-06-07T07:10:59Z","extern":"1","publication_status":"published","title":"DNA demethylation is initiated in the central cells of Arabidopsis and rice","article_processing_charge":"No","publication":"Proceedings of the National Academy of Sciences","status":"public","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","date_published":"2016-12-27T00:00:00Z","month":"12","author":[{"full_name":"Park, Kyunghyuk","first_name":"Kyunghyuk","last_name":"Park"},{"first_name":"M. Yvonne","last_name":"Kim","full_name":"Kim, M. Yvonne"},{"last_name":"Vickers","first_name":"Martin","full_name":"Vickers, Martin"},{"first_name":"Jin-Sup","last_name":"Park","full_name":"Park, Jin-Sup"},{"last_name":"Hyun","first_name":"Youbong","full_name":"Hyun, Youbong"},{"last_name":"Okamoto","first_name":"Takashi","full_name":"Okamoto, Takashi"},{"last_name":"Zilberman","first_name":"Daniel","full_name":"Zilberman, Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","orcid":"0000-0002-0123-8649"},{"full_name":"Fischer, Robert L.","last_name":"Fischer","first_name":"Robert L."},{"last_name":"Feng","first_name":"Xiaoqi","full_name":"Feng, Xiaoqi","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","orcid":"0000-0002-4008-1234"},{"last_name":"Choi","first_name":"Yeonhee","full_name":"Choi, Yeonhee"},{"last_name":"Scholten","first_name":"Stefan","full_name":"Scholten, Stefan"}],"date_updated":"2023-05-08T11:00:07Z","oa":1,"intvolume":"       113","department":[{"_id":"DaZi"},{"_id":"XiFe"}],"scopus_import":"1","oa_version":"Published Version","_id":"9477","abstract":[{"lang":"eng","text":"Cytosine methylation is a DNA modification with important regulatory functions in eukaryotes. In flowering plants, sexual reproduction is accompanied by extensive DNA demethylation, which is required for proper gene expression in the endosperm, a nutritive extraembryonic seed tissue. Endosperm arises from a fusion of a sperm cell carried in the pollen and a female central cell. Endosperm DNA demethylation is observed specifically on the chromosomes inherited from the central cell in Arabidopsis thaliana, rice, and maize, and requires the DEMETER DNA demethylase in Arabidopsis. DEMETER is expressed in the central cell before fertilization, suggesting that endosperm demethylation patterns are inherited from the central cell. Down-regulation of the MET1 DNA methyltransferase has also been proposed to contribute to central cell demethylation. However, with the exception of three maize genes, central cell DNA methylation has not been directly measured, leaving the origin and mechanism of endosperm demethylation uncertain. Here, we report genome-wide analysis of DNA methylation in the central cells of Arabidopsis and rice—species that diverged 150 million years ago—as well as in rice egg cells. We find that DNA demethylation in both species is initiated in central cells, which requires DEMETER in Arabidopsis. However, we do not observe a global reduction of CG methylation that would be indicative of lowered MET1 activity; on the contrary, CG methylation efficiency is elevated in female gametes compared with nonsexual tissues. Our results demonstrate that locus-specific, active DNA demethylation in the central cell is the origin of maternal chromosome hypomethylation in the endosperm."}],"external_id":{"pmid":["27956642"]},"page":"15138-15143","publisher":"National Academy of Sciences","issue":"52","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1073/pnas.1619047114"}],"citation":{"ieee":"K. Park <i>et al.</i>, “DNA demethylation is initiated in the central cells of Arabidopsis and rice,” <i>Proceedings of the National Academy of Sciences</i>, vol. 113, no. 52. National Academy of Sciences, pp. 15138–15143, 2016.","ama":"Park K, Kim MY, Vickers M, et al. DNA demethylation is initiated in the central cells of Arabidopsis and rice. <i>Proceedings of the National Academy of Sciences</i>. 2016;113(52):15138-15143. doi:<a href=\"https://doi.org/10.1073/pnas.1619047114\">10.1073/pnas.1619047114</a>","mla":"Park, Kyunghyuk, et al. “DNA Demethylation Is Initiated in the Central Cells of Arabidopsis and Rice.” <i>Proceedings of the National Academy of Sciences</i>, vol. 113, no. 52, National Academy of Sciences, 2016, pp. 15138–43, doi:<a href=\"https://doi.org/10.1073/pnas.1619047114\">10.1073/pnas.1619047114</a>.","chicago":"Park, Kyunghyuk, M. Yvonne Kim, Martin Vickers, Jin-Sup Park, Youbong Hyun, Takashi Okamoto, Daniel Zilberman, et al. “DNA Demethylation Is Initiated in the Central Cells of Arabidopsis and Rice.” <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences, 2016. <a href=\"https://doi.org/10.1073/pnas.1619047114\">https://doi.org/10.1073/pnas.1619047114</a>.","apa":"Park, K., Kim, M. Y., Vickers, M., Park, J.-S., Hyun, Y., Okamoto, T., … Scholten, S. (2016). DNA demethylation is initiated in the central cells of Arabidopsis and rice. <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1619047114\">https://doi.org/10.1073/pnas.1619047114</a>","ista":"Park K, Kim MY, Vickers M, Park J-S, Hyun Y, Okamoto T, Zilberman D, Fischer RL, Feng X, Choi Y, Scholten S. 2016. DNA demethylation is initiated in the central cells of Arabidopsis and rice. Proceedings of the National Academy of Sciences. 113(52), 15138–15143.","short":"K. Park, M.Y. Kim, M. Vickers, J.-S. Park, Y. Hyun, T. Okamoto, D. Zilberman, R.L. Fischer, X. Feng, Y. Choi, S. Scholten, Proceedings of the National Academy of Sciences 113 (2016) 15138–15143."},"pmid":1,"keyword":["Multidisciplinary"],"doi":"10.1073/pnas.1619047114","quality_controlled":"1"},{"volume":29,"day":"01","year":"2016","conference":{"name":"NIPS: Neural Information Processing Systems","start_date":"2016-12-05","end_date":"2016-12-10","location":"Barcelona, Spaine"},"language":[{"iso":"eng"}],"date_created":"2018-12-11T11:49:21Z","alternative_title":["Advances in Neural Information Processing Systems"],"ec_funded":1,"article_processing_charge":"No","title":"Neurons equipped with intrinsic plasticity learn stimulus intensity statistics","acknowledgement":"DFG Cluster of Excellence EXC 1077/1 (Hearing4all) and  LU 1196/5-1 (JL and TM), People Programme (Marie Curie Actions) FP7/2007-2013 grant agreement no. 291734 (CS)","publication_status":"published","author":[{"first_name":"Travis","last_name":"Monk","full_name":"Monk, Travis"},{"id":"3933349E-F248-11E8-B48F-1D18A9856A87","full_name":"Savin, Cristina","first_name":"Cristina","last_name":"Savin"},{"last_name":"Lücke","first_name":"Jörg","full_name":"Lücke, Jörg"}],"date_published":"2016-01-01T00:00:00Z","month":"01","status":"public","publist_id":"6469","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference","date_updated":"2025-06-03T11:18:32Z","oa":1,"department":[{"_id":"GaTk"}],"intvolume":"        29","project":[{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734"}],"page":"4285 - 4293","abstract":[{"lang":"eng","text":"Experience constantly shapes neural circuits through a variety of plasticity mechanisms. While the functional roles of some plasticity mechanisms are well-understood, it remains unclear how changes in neural excitability contribute to learning. Here, we develop a normative interpretation of intrinsic plasticity (IP) as a key component of unsupervised learning. We introduce a novel generative mixture model that accounts for the class-specific statistics of stimulus intensities, and we derive a neural circuit that learns the input classes and their intensities. We will analytically show that inference and learning for our generative model can be achieved by a neural circuit with intensity-sensitive neurons equipped with a specific form of IP. Numerical experiments verify our analytical derivations and show robust behavior for artificial and natural stimuli. Our results link IP to non-trivial input statistics, in particular the statistics of stimulus intensities for classes to which a neuron is sensitive. More generally, our work paves the way toward new classification algorithms that are robust to intensity variations."}],"publisher":"Neural Information Processing Systems Foundation","scopus_import":"1","_id":"948","oa_version":"None","quality_controlled":"1","citation":{"short":"T. Monk, C. Savin, J. Lücke, in:, Neural Information Processing Systems Foundation, 2016, pp. 4285–4293.","ista":"Monk T, Savin C, Lücke J. 2016. Neurons equipped with intrinsic plasticity learn stimulus intensity statistics. NIPS: Neural Information Processing Systems, Advances in Neural Information Processing Systems, vol. 29, 4285–4293.","apa":"Monk, T., Savin, C., &#38; Lücke, J. (2016). Neurons equipped with intrinsic plasticity learn stimulus intensity statistics (Vol. 29, pp. 4285–4293). Presented at the NIPS: Neural Information Processing Systems, Barcelona, Spaine: Neural Information Processing Systems Foundation.","mla":"Monk, Travis, et al. <i>Neurons Equipped with Intrinsic Plasticity Learn Stimulus Intensity Statistics</i>. Vol. 29, Neural Information Processing Systems Foundation, 2016, pp. 4285–93.","chicago":"Monk, Travis, Cristina Savin, and Jörg Lücke. “Neurons Equipped with Intrinsic Plasticity Learn Stimulus Intensity Statistics,” 29:4285–93. Neural Information Processing Systems Foundation, 2016.","ama":"Monk T, Savin C, Lücke J. Neurons equipped with intrinsic plasticity learn stimulus intensity statistics. In: Vol 29. Neural Information Processing Systems Foundation; 2016:4285-4293.","ieee":"T. Monk, C. Savin, and J. Lücke, “Neurons equipped with intrinsic plasticity learn stimulus intensity statistics,” presented at the NIPS: Neural Information Processing Systems, Barcelona, Spaine, 2016, vol. 29, pp. 4285–4293."},"main_file_link":[{"url":"https://papers.nips.cc/paper/6582-neurons-equipped-with-intrinsic-plasticity-learn-stimulus-intensity-statistics","open_access":"1"}]},{"publication_status":"published","title":"Cycles and matchings in randomly perturbed digraphs and hypergraphs","article_processing_charge":"No","publication":"Combinatorics, Probability and Computing","extern":"1","language":[{"iso":"eng"}],"date_created":"2021-06-22T12:35:13Z","year":"2016","day":"01","publication_identifier":{"issn":["0963-5483"],"eissn":["1469-2163"]},"volume":25,"issue":"6","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1501.04816"}],"citation":{"ieee":"M. Krivelevich, M. A. Kwan, and B. Sudakov, “Cycles and matchings in randomly perturbed digraphs and hypergraphs,” <i>Combinatorics, Probability and Computing</i>, vol. 25, no. 6. Cambridge University Press, pp. 909–927, 2016.","ama":"Krivelevich M, Kwan MA, Sudakov B. Cycles and matchings in randomly perturbed digraphs and hypergraphs. <i>Combinatorics, Probability and Computing</i>. 2016;25(6):909-927. doi:<a href=\"https://doi.org/10.1017/s0963548316000079\">10.1017/s0963548316000079</a>","chicago":"Krivelevich, Michael, Matthew Alan Kwan, and Benny Sudakov. “Cycles and Matchings in Randomly Perturbed Digraphs and Hypergraphs.” <i>Combinatorics, Probability and Computing</i>. Cambridge University Press, 2016. <a href=\"https://doi.org/10.1017/s0963548316000079\">https://doi.org/10.1017/s0963548316000079</a>.","mla":"Krivelevich, Michael, et al. “Cycles and Matchings in Randomly Perturbed Digraphs and Hypergraphs.” <i>Combinatorics, Probability and Computing</i>, vol. 25, no. 6, Cambridge University Press, 2016, pp. 909–27, doi:<a href=\"https://doi.org/10.1017/s0963548316000079\">10.1017/s0963548316000079</a>.","apa":"Krivelevich, M., Kwan, M. A., &#38; Sudakov, B. (2016). Cycles and matchings in randomly perturbed digraphs and hypergraphs. <i>Combinatorics, Probability and Computing</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/s0963548316000079\">https://doi.org/10.1017/s0963548316000079</a>","ista":"Krivelevich M, Kwan MA, Sudakov B. 2016. Cycles and matchings in randomly perturbed digraphs and hypergraphs. Combinatorics, Probability and Computing. 25(6), 909–927.","short":"M. Krivelevich, M.A. Kwan, B. Sudakov, Combinatorics, Probability and Computing 25 (2016) 909–927."},"doi":"10.1017/s0963548316000079","quality_controlled":"1","scopus_import":"1","_id":"9591","oa_version":"Preprint","abstract":[{"lang":"eng","text":"We give several results showing that different discrete structures typically gain certain spanning substructures (in particular, Hamilton cycles) after a modest random perturbation. First, we prove that adding linearly many random edges to a dense k-uniform hypergraph ensures the (asymptotically almost sure) existence of a perfect matching or a loose Hamilton cycle. The proof involves an interesting application of Szemerédi's Regularity Lemma, which might be independently useful. We next prove that digraphs with certain strong expansion properties are pancyclic, and use this to show that adding a linear number of random edges typically makes a dense digraph pancyclic. Finally, we prove that perturbing a certain (minimum-degree-dependent) number of random edges in a tournament typically ensures the existence of multiple edge-disjoint Hamilton cycles. All our results are tight."}],"page":"909-927","external_id":{"arxiv":["1501.04816"]},"publisher":"Cambridge University Press","date_updated":"2023-02-23T14:02:07Z","oa":1,"intvolume":"        25","arxiv":1,"status":"public","article_type":"original","type":"journal_article","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","month":"11","date_published":"2016-11-01T00:00:00Z","author":[{"full_name":"Krivelevich, Michael","first_name":"Michael","last_name":"Krivelevich"},{"last_name":"Kwan","first_name":"Matthew Alan","full_name":"Kwan, Matthew Alan","orcid":"0000-0002-4003-7567","id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3"},{"full_name":"Sudakov, Benny","last_name":"Sudakov","first_name":"Benny"}]}]