[{"_id":"1500","title":"Poster: HyRG: A random generation tool for affine hybrid automata","OA_place":"publisher","main_file_link":[{"url":"https://doi.org/10.1145/2728606.2728650","open_access":"1"}],"publisher":"Association for Computing Machinery","publication":"Proceedings of the 18th International Conference on Hybrid Systems: Computation and Control","citation":{"ama":"Nguyen L, Schilling C, Bogomolov S, Johnson T. <i>Poster: HyRG: A Random Generation Tool for Affine Hybrid Automata</i>. Association for Computing Machinery; 2015:289-290. doi:<a href=\"https://doi.org/10.1145/2728606.2728650\">10.1145/2728606.2728650</a>","ieee":"L. Nguyen, C. Schilling, S. Bogomolov, and T. Johnson, <i>Poster: HyRG: A random generation tool for affine hybrid automata</i>. Association for Computing Machinery, 2015, pp. 289–290.","apa":"Nguyen, L., Schilling, C., Bogomolov, S., &#38; Johnson, T. (2015). <i>Poster: HyRG: A random generation tool for affine hybrid automata</i>. <i>Proceedings of the 18th International Conference on Hybrid Systems: Computation and Control</i> (pp. 289–290). Seattle, WA, United States: Association for Computing Machinery. <a href=\"https://doi.org/10.1145/2728606.2728650\">https://doi.org/10.1145/2728606.2728650</a>","mla":"Nguyen, Luan, et al. “Poster: HyRG: A Random Generation Tool for Affine Hybrid Automata.” <i>Proceedings of the 18th International Conference on Hybrid Systems: Computation and Control</i>, Association for Computing Machinery, 2015, pp. 289–90, doi:<a href=\"https://doi.org/10.1145/2728606.2728650\">10.1145/2728606.2728650</a>.","short":"L. Nguyen, C. Schilling, S. Bogomolov, T. Johnson, Poster: HyRG: A Random Generation Tool for Affine Hybrid Automata, Association for Computing Machinery, 2015.","chicago":"Nguyen, Luan, Christian Schilling, Sergiy Bogomolov, and Taylor Johnson. <i>Poster: HyRG: A Random Generation Tool for Affine Hybrid Automata</i>. <i>Proceedings of the 18th International Conference on Hybrid Systems: Computation and Control</i>. Association for Computing Machinery, 2015. <a href=\"https://doi.org/10.1145/2728606.2728650\">https://doi.org/10.1145/2728606.2728650</a>.","ista":"Nguyen L, Schilling C, Bogomolov S, Johnson T. 2015. Poster: HyRG: A random generation tool for affine hybrid automata, Association for Computing Machinery,p."},"day":"14","OA_type":"free access","date_updated":"2026-05-19T10:01:13Z","conference":{"end_date":"2015-04-16","name":"HSCC: International Conference on Hybrid Systems","start_date":"2015-04-14","location":"Seattle, WA, United States"},"oa_version":"Published Version","scopus_import":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","page":"289 - 290","status":"public","doi":"10.1145/2728606.2728650","publication_identifier":{"eisbn":["9781450334334"]},"quality_controlled":"1","article_processing_charge":"No","extern":"1","type":"conference_poster","date_created":"2018-12-11T11:52:23Z","date_published":"2015-04-14T00:00:00Z","publist_id":"5678","year":"2015","oa":1,"language":[{"iso":"eng"}],"month":"04","abstract":[{"lang":"eng","text":"In this poster, we present methods for randomly generating hybrid automata with affine differential equations, invariants, guards, and assignments. Selecting an arbitrary affine function from the set of all affine functions results in a low likelihood of generating hybrid automata with diverse and interesting behaviors, as there are an uncountable number of elements in the set of all affine functions. Instead, we partition the set of all affine functions into potentially interesting classes and randomly select elements from these classes. For example, we partition the set of all affine differential equations by using restrictions on eigenvalues such as those that yield stable, unstable, etc. equilibrium points. We partition the components describing discrete behavior (guards, assignments, and invariants) to allow either time-dependent or state-dependent switching, and in particular provide the ability to generate subclasses of piecewise-affine hybrid automata. Our preliminary experimental results with a prototype tool called HyRG (Hybrid Random Generator) illustrate the feasibility of this generation method to automatically create standard hybrid automaton examples like the bouncing ball and thermostat."}],"publication_status":"published","author":[{"full_name":"Nguyen, Luan","last_name":"Nguyen","first_name":"Luan"},{"id":"3A2F4DCE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-3658-1065","full_name":"Schilling, Christian","last_name":"Schilling","first_name":"Christian"},{"first_name":"Sergiy","last_name":"Bogomolov","full_name":"Bogomolov, Sergiy","orcid":"0000-0002-0686-0365","id":"369D9A44-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Johnson, Taylor","first_name":"Taylor","last_name":"Johnson"}]},{"_id":"1501","title":"CEGAR for compositional analysis of qualitative properties in Markov decision processes","main_file_link":[{"url":"https://arxiv.org/abs/1405.0835","open_access":"1"}],"department":[{"_id":"KrCh"},{"_id":"ToHe"}],"publisher":"Springer","publication":"Formal Methods in System Design","citation":{"chicago":"Chatterjee, Krishnendu, Martin Chmelik, and Przemyslaw Daca. “CEGAR for Compositional Analysis of Qualitative Properties in Markov Decision Processes.” <i>Formal Methods in System Design</i>. Springer, 2015. <a href=\"https://doi.org/10.1007/s10703-015-0235-2\">https://doi.org/10.1007/s10703-015-0235-2</a>.","ista":"Chatterjee K, Chmelik M, Daca P. 2015. CEGAR for compositional analysis of qualitative properties in Markov decision processes. Formal Methods in System Design. 47(2), 230–264.","short":"K. Chatterjee, M. Chmelik, P. Daca, Formal Methods in System Design 47 (2015) 230–264.","ieee":"K. Chatterjee, M. Chmelik, and P. Daca, “CEGAR for compositional analysis of qualitative properties in Markov decision processes,” <i>Formal Methods in System Design</i>, vol. 47, no. 2. Springer, pp. 230–264, 2015.","apa":"Chatterjee, K., Chmelik, M., &#38; Daca, P. (2015). CEGAR for compositional analysis of qualitative properties in Markov decision processes. <i>Formal Methods in System Design</i>. Springer. <a href=\"https://doi.org/10.1007/s10703-015-0235-2\">https://doi.org/10.1007/s10703-015-0235-2</a>","mla":"Chatterjee, Krishnendu, et al. “CEGAR for Compositional Analysis of Qualitative Properties in Markov Decision Processes.” <i>Formal Methods in System Design</i>, vol. 47, no. 2, Springer, 2015, pp. 230–64, doi:<a href=\"https://doi.org/10.1007/s10703-015-0235-2\">10.1007/s10703-015-0235-2</a>.","ama":"Chatterjee K, Chmelik M, Daca P. CEGAR for compositional analysis of qualitative properties in Markov decision processes. <i>Formal Methods in System Design</i>. 2015;47(2):230-264. doi:<a href=\"https://doi.org/10.1007/s10703-015-0235-2\">10.1007/s10703-015-0235-2</a>"},"day":"01","date_updated":"2026-04-15T10:02:12Z","oa_version":"Preprint","scopus_import":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"230 - 264","related_material":{"record":[{"id":"1155","relation":"dissertation_contains","status":"public"}]},"status":"public","ec_funded":1,"doi":"10.1007/s10703-015-0235-2","quality_controlled":"1","article_processing_charge":"No","arxiv":1,"type":"journal_article","date_created":"2018-12-11T11:52:23Z","date_published":"2015-10-01T00:00:00Z","publist_id":"5677","year":"2015","intvolume":"        47","isi":1,"oa":1,"issue":"2","acknowledgement":"The research was partly supported by Austrian Science Fund (FWF) Grant No. P23499- N23, FWF NFN Grant No. S11407-N23, FWF Grant S11403-N23 (RiSE), and FWF Grant Z211-N23 (Wittgenstein Award), ERC Start Grant (279307: Graph Games), Microsoft faculty fellows award, the ERC Advanced Grant QUAREM (Quantitative Reactive Modeling).","language":[{"iso":"eng"}],"month":"10","abstract":[{"text":"We consider Markov decision processes (MDPs) which are a standard model for probabilistic systems. We focus on qualitative properties for MDPs that can express that desired behaviors of the system arise almost-surely (with probability 1) or with positive probability. We introduce a new simulation relation to capture the refinement relation of MDPs with respect to qualitative properties, and present discrete graph algorithms with quadratic complexity to compute the simulation relation. We present an automated technique for assume-guarantee style reasoning for compositional analysis of two-player games by giving a counterexample guided abstraction-refinement approach to compute our new simulation relation. We show a tight link between two-player games and MDPs, and as a consequence the results for games are lifted to MDPs with qualitative properties. We have implemented our algorithms and show that the compositional analysis leads to significant improvements. ","lang":"eng"}],"volume":47,"project":[{"_id":"2584A770-B435-11E9-9278-68D0E5697425","name":"Modern Graph Algorithmic Techniques in Formal Verification","grant_number":"P 23499-N23","call_identifier":"FWF"},{"_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","grant_number":"S 11407_N23","call_identifier":"FWF"},{"name":"Quantitative Graph Games: Theory and Applications","call_identifier":"FP7","grant_number":"279307","_id":"2581B60A-B435-11E9-9278-68D0E5697425"},{"_id":"2587B514-B435-11E9-9278-68D0E5697425","name":"Microsoft Research Faculty Fellowship"},{"grant_number":"267989","call_identifier":"FP7","name":"Quantitative Reactive Modeling","_id":"25EE3708-B435-11E9-9278-68D0E5697425"}],"publication_status":"published","external_id":{"isi":["000361752300003"],"arxiv":["1405.0835"]},"corr_author":"1","author":[{"full_name":"Chatterjee, Krishnendu","orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu","last_name":"Chatterjee"},{"full_name":"Chmelik, Martin","id":"3624234E-F248-11E8-B48F-1D18A9856A87","first_name":"Martin","last_name":"Chmelik"},{"full_name":"Daca, Przemyslaw","id":"49351290-F248-11E8-B48F-1D18A9856A87","first_name":"Przemyslaw","last_name":"Daca"}]},{"conference":{"start_date":"2015-05-04","name":"CBSE: Component-Based Software Engineering ","location":"Montreal, QC, Canada","end_date":"2015-05-08"},"related_material":{"record":[{"id":"1155","relation":"dissertation_contains","status":"public"}]},"page":"101 - 110","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","scopus_import":"1","oa_version":"Submitted Version","ec_funded":1,"status":"public","quality_controlled":"1","doi":"10.1145/2737166.2737175","publication_identifier":{"isbn":["978-1-4503-3471-6"]},"article_processing_charge":"No","type":"conference","ddc":["000"],"_id":"1502","title":"Complete composition operators for IOCO-testing theory","department":[{"_id":"ToHe"},{"_id":"KrCh"}],"publisher":"ACM","file":[{"file_id":"5303","checksum":"c6ce681035c163a158751f240cb7d389","date_updated":"2020-07-14T12:44:59Z","file_name":"IST-2016-625-v1+1_conf-cbse-BenesDHKN15.pdf","access_level":"open_access","relation":"main_file","date_created":"2018-12-12T10:17:46Z","file_size":467561,"content_type":"application/pdf","creator":"system"}],"citation":{"ieee":"N. Beneš, P. Daca, T. A. Henzinger, J. Kretinsky, and D. Nickovic, “Complete composition operators for IOCO-testing theory,” presented at the CBSE: Component-Based Software Engineering , Montreal, QC, Canada, 2015, pp. 101–110.","mla":"Beneš, Nikola, et al. <i>Complete Composition Operators for IOCO-Testing Theory</i>. ACM, 2015, pp. 101–10, doi:<a href=\"https://doi.org/10.1145/2737166.2737175\">10.1145/2737166.2737175</a>.","apa":"Beneš, N., Daca, P., Henzinger, T. A., Kretinsky, J., &#38; Nickovic, D. (2015). Complete composition operators for IOCO-testing theory (pp. 101–110). Presented at the CBSE: Component-Based Software Engineering , Montreal, QC, Canada: ACM. <a href=\"https://doi.org/10.1145/2737166.2737175\">https://doi.org/10.1145/2737166.2737175</a>","ama":"Beneš N, Daca P, Henzinger TA, Kretinsky J, Nickovic D. Complete composition operators for IOCO-testing theory. In: ACM; 2015:101-110. doi:<a href=\"https://doi.org/10.1145/2737166.2737175\">10.1145/2737166.2737175</a>","chicago":"Beneš, Nikola, Przemyslaw Daca, Thomas A Henzinger, Jan Kretinsky, and Dejan Nickovic. “Complete Composition Operators for IOCO-Testing Theory,” 101–10. ACM, 2015. <a href=\"https://doi.org/10.1145/2737166.2737175\">https://doi.org/10.1145/2737166.2737175</a>.","ista":"Beneš N, Daca P, Henzinger TA, Kretinsky J, Nickovic D. 2015. Complete composition operators for IOCO-testing theory. CBSE: Component-Based Software Engineering , Proceedings of the 18th International ACM SIGSOFT Symposium on Component-Based Software Engineering , , 101–110.","short":"N. Beneš, P. Daca, T.A. Henzinger, J. Kretinsky, D. Nickovic, in:, ACM, 2015, pp. 101–110."},"has_accepted_license":"1","alternative_title":["Proceedings of the 18th International ACM SIGSOFT Symposium on Component-Based Software Engineering "],"day":"01","date_updated":"2026-04-15T10:02:12Z","project":[{"name":"Quantitative Reactive Modeling","call_identifier":"FP7","grant_number":"267989","_id":"25EE3708-B435-11E9-9278-68D0E5697425"},{"_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","grant_number":"S 11407_N23","call_identifier":"FWF"},{"_id":"25F42A32-B435-11E9-9278-68D0E5697425","grant_number":"Z211","call_identifier":"FWF","name":"Formal methods for the design and analysis of complex systems"},{"_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","grant_number":"291734","call_identifier":"FP7"}],"pubrep_id":"625","publication_status":"published","external_id":{"isi":["000380554800013"]},"author":[{"first_name":"Nikola","last_name":"Beneš","full_name":"Beneš, Nikola"},{"first_name":"Przemyslaw","last_name":"Daca","full_name":"Daca, Przemyslaw","id":"49351290-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Thomas A","last_name":"Henzinger","full_name":"Henzinger, Thomas A","orcid":"0000−0002−2985−7724","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jan","last_name":"Kretinsky","full_name":"Kretinsky, Jan","orcid":"0000-0002-8122-2881","id":"44CEF464-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Nickovic, Dejan","last_name":"Nickovic","first_name":"Dejan"}],"date_created":"2018-12-11T11:52:24Z","year":"2015","publist_id":"5676","date_published":"2015-05-01T00:00:00Z","file_date_updated":"2020-07-14T12:44:59Z","isi":1,"oa":1,"language":[{"iso":"eng"}],"acknowledgement":"This research was funded in part by the European Research Council (ERC) under grant agreement 267989 (QUAREM), by the Austrian Science Fund (FWF) projects S11402-N23(RiSE) and Z211-N23 (Wittgestein Award), by People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement 291734, and by the ARTEMIS JU under grant agreement 295373 (nSafeCer).  Jan Křetínský has been partially supported by the Czech Science Foundation, grant No.  P202/12/G061.  Nikola Beneš has been supported by the\r\nMEYS project No. CZ.1.07/2.3.00/30.0009 Employment of Newly Graduated Doctors of Science for Scientific Excellence.","month":"05","abstract":[{"text":"We extend the theory of input-output conformance with operators for merge and quotient. The former is useful when testing against multiple requirements or views. The latter can be used to generate tests for patches of an already tested system. Both operators can combine systems with different action alphabets, which is usually the case when constructing complex systems and specifications from parts, for instance different views as well as newly defined functionality of a~previous version of the system.","lang":"eng"}]},{"article_processing_charge":"No","type":"journal_article","extern":"1","oa_version":"Preprint","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"1582 - 1591","status":"public","doi":"10.1017/etds.2013.103","quality_controlled":"1","day":"14","date_updated":"2025-09-22T14:31:00Z","title":"A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary and Hermitian-symplectic-cocycles","_id":"1503","main_file_link":[{"url":"https://arxiv.org/abs/1307.8414","open_access":"1"}],"publisher":"Cambridge University Press","publication":"Ergodic Theory and Dynamical Systems","citation":{"apa":"Sadel, C. (2015). A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary and Hermitian-symplectic-cocycles. <i>Ergodic Theory and Dynamical Systems</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/etds.2013.103\">https://doi.org/10.1017/etds.2013.103</a>","mla":"Sadel, Christian. “A Herman-Avila-Bochi Formula for Higher-Dimensional Pseudo-Unitary and Hermitian-Symplectic-Cocycles.” <i>Ergodic Theory and Dynamical Systems</i>, vol. 35, no. 5, Cambridge University Press, 2015, pp. 1582–91, doi:<a href=\"https://doi.org/10.1017/etds.2013.103\">10.1017/etds.2013.103</a>.","ieee":"C. Sadel, “A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary and Hermitian-symplectic-cocycles,” <i>Ergodic Theory and Dynamical Systems</i>, vol. 35, no. 5. Cambridge University Press, pp. 1582–1591, 2015.","ama":"Sadel C. A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary and Hermitian-symplectic-cocycles. <i>Ergodic Theory and Dynamical Systems</i>. 2015;35(5):1582-1591. doi:<a href=\"https://doi.org/10.1017/etds.2013.103\">10.1017/etds.2013.103</a>","ista":"Sadel C. 2015. A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary and Hermitian-symplectic-cocycles. Ergodic Theory and Dynamical Systems. 35(5), 1582–1591.","chicago":"Sadel, Christian. “A Herman-Avila-Bochi Formula for Higher-Dimensional Pseudo-Unitary and Hermitian-Symplectic-Cocycles.” <i>Ergodic Theory and Dynamical Systems</i>. Cambridge University Press, 2015. <a href=\"https://doi.org/10.1017/etds.2013.103\">https://doi.org/10.1017/etds.2013.103</a>.","short":"C. Sadel, Ergodic Theory and Dynamical Systems 35 (2015) 1582–1591."},"publication_status":"published","external_id":{"isi":["000357605900010"]},"author":[{"first_name":"Christian","last_name":"Sadel","full_name":"Sadel, Christian","orcid":"0000-0001-8255-3968","id":"4760E9F8-F248-11E8-B48F-1D18A9856A87"}],"month":"03","abstract":[{"lang":"eng","text":"A Herman-Avila-Bochi type formula is obtained for the average sum of the top d Lyapunov exponents over a one-parameter family of double-struck G-cocycles, where double-struck G is the group that leaves a certain, non-degenerate Hermitian form of signature (c, d) invariant. The generic example of such a group is the pseudo-unitary group U(c, d) or, in the case c = d, the Hermitian-symplectic group HSp(2d) which naturally appears for cocycles related to Schrödinger operators. In the case d = 1, the formula for HSp(2d) cocycles reduces to the Herman-Avila-Bochi formula for SL(2, ℝ) cocycles."}],"volume":35,"date_created":"2018-12-11T11:52:24Z","date_published":"2015-03-14T00:00:00Z","publist_id":"5675","year":"2015","intvolume":"        35","language":[{"iso":"eng"}],"oa":1,"issue":"5","isi":1},{"_id":"1504","title":"Spectral statistics of large dimensional spearman s rank correlation matrix and its application","publisher":"Institute of Mathematical Statistics","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1312.5119"}],"citation":{"chicago":"Bao, Zhigang, Liang Lin, Guangming Pan, and Wang Zhou. “Spectral Statistics of Large Dimensional Spearman s Rank Correlation Matrix and Its Application.” <i>Annals of Statistics</i>. Institute of Mathematical Statistics, 2015. <a href=\"https://doi.org/10.1214/15-AOS1353\">https://doi.org/10.1214/15-AOS1353</a>.","ista":"Bao Z, Lin L, Pan G, Zhou W. 2015. Spectral statistics of large dimensional spearman s rank correlation matrix and its application. Annals of Statistics. 43(6), 2588–2623.","short":"Z. Bao, L. Lin, G. Pan, W. Zhou, Annals of Statistics 43 (2015) 2588–2623.","ieee":"Z. Bao, L. Lin, G. Pan, and W. Zhou, “Spectral statistics of large dimensional spearman s rank correlation matrix and its application,” <i>Annals of Statistics</i>, vol. 43, no. 6. Institute of Mathematical Statistics, pp. 2588–2623, 2015.","apa":"Bao, Z., Lin, L., Pan, G., &#38; Zhou, W. (2015). Spectral statistics of large dimensional spearman s rank correlation matrix and its application. <i>Annals of Statistics</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/15-AOS1353\">https://doi.org/10.1214/15-AOS1353</a>","mla":"Bao, Zhigang, et al. “Spectral Statistics of Large Dimensional Spearman s Rank Correlation Matrix and Its Application.” <i>Annals of Statistics</i>, vol. 43, no. 6, Institute of Mathematical Statistics, 2015, pp. 2588–623, doi:<a href=\"https://doi.org/10.1214/15-AOS1353\">10.1214/15-AOS1353</a>.","ama":"Bao Z, Lin L, Pan G, Zhou W. Spectral statistics of large dimensional spearman s rank correlation matrix and its application. <i>Annals of Statistics</i>. 2015;43(6):2588-2623. doi:<a href=\"https://doi.org/10.1214/15-AOS1353\">10.1214/15-AOS1353</a>"},"publication":"Annals of Statistics","day":"01","date_updated":"2025-09-23T10:47:55Z","page":"2588 - 2623","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa_version":"Published Version","status":"public","quality_controlled":"1","doi":"10.1214/15-AOS1353","article_processing_charge":"No","extern":"1","type":"journal_article","date_created":"2018-12-11T11:52:24Z","year":"2015","publist_id":"5674","date_published":"2015-12-01T00:00:00Z","intvolume":"        43","issue":"6","isi":1,"oa":1,"language":[{"iso":"eng"}],"month":"12","abstract":[{"text":"Let Q = (Q1, . . . , Qn) be a random vector drawn from the uniform distribution on the set of all n! permutations of {1, 2, . . . , n}. Let Z = (Z1, . . . , Zn), where Zj is the mean zero variance one random variable obtained by centralizing and normalizing Qj , j = 1, . . . , n. Assume that Xi , i = 1, . . . ,p are i.i.d. copies of 1/√ p Z and X = Xp,n is the p × n random matrix with Xi as its ith row. Then Sn = XX is called the p × n Spearman's rank correlation matrix which can be regarded as a high dimensional extension of the classical nonparametric statistic Spearman's rank correlation coefficient between two independent random variables. In this paper, we establish a CLT for the linear spectral statistics of this nonparametric random matrix model in the scenario of high dimension, namely, p = p(n) and p/n→c ∈ (0,∞) as n→∞.We propose a novel evaluation scheme to estimate the core quantity in Anderson and Zeitouni's cumulant method in [Ann. Statist. 36 (2008) 2553-2576] to bypass the so-called joint cumulant summability. In addition, we raise a two-step comparison approach to obtain the explicit formulae for the mean and covariance functions in the CLT. Relying on this CLT, we then construct a distribution-free statistic to test complete independence for components of random vectors. Owing to the nonparametric property, we can use this test on generally distributed random variables including the heavy-tailed ones.","lang":"eng"}],"volume":43,"publication_status":"published","external_id":{"isi":["000363437900010"]},"author":[{"last_name":"Bao","first_name":"Zhigang","id":"442E6A6C-F248-11E8-B48F-1D18A9856A87","full_name":"Bao, Zhigang","orcid":"0000-0003-3036-1475"},{"first_name":"Liang","last_name":"Lin","full_name":"Lin, Liang"},{"first_name":"Guangming","last_name":"Pan","full_name":"Pan, Guangming"},{"first_name":"Wang","last_name":"Zhou","full_name":"Zhou, Wang"}]},{"publist_id":"5672","year":"2015","date_published":"2015-02-01T00:00:00Z","date_created":"2018-12-11T11:52:25Z","oa":1,"isi":1,"acknowledgement":"B.Z. was supported  in  part  by  NSFC  Grant  11071213,  ZJNSF  Grant  R6090034  and  SRFDP  Grant 20100101110001. P.G. was supported in part by the Ministry of Education, Singapore, under Grant ARC 14/11. Z.W. was supported  in  part  by  the  Ministry  of  Education,  Singapore,  under  Grant  ARC  14/11,  and  by a Grant R-155-000-131-112 at the National University of Singapore\r\n","issue":"1","language":[{"iso":"eng"}],"intvolume":"        43","abstract":[{"text":"This paper is aimed at deriving the universality of the largest eigenvalue of a class of high-dimensional real or complex sample covariance matrices of the form W N =Σ 1/2XX∗Σ 1/2 . Here, X = (xij )M,N is an M× N random matrix with independent entries xij , 1 ≤ i M,≤ 1 ≤ j ≤ N such that Exij = 0, E|xij |2 = 1/N . On dimensionality, we assume that M = M(N) and N/M → d ε (0, ∞) as N ∞→. For a class of general deterministic positive-definite M × M matrices Σ , under some additional assumptions on the distribution of xij 's, we show that the limiting behavior of the largest eigenvalue of W N is universal, via pursuing a Green function comparison strategy raised in [Probab. Theory Related Fields 154 (2012) 341-407, Adv. Math. 229 (2012) 1435-1515] by Erd″os, Yau and Yin for Wigner matrices and extended by Pillai and Yin [Ann. Appl. Probab. 24 (2014) 935-1001] to sample covariance matrices in the null case (&amp;Epsi = I ). Consequently, in the standard complex case (Ex2 ij = 0), combing this universality property and the results known for Gaussian matrices obtained by El Karoui in [Ann. Probab. 35 (2007) 663-714] (nonsingular case) and Onatski in [Ann. Appl. Probab. 18 (2008) 470-490] (singular case), we show that after an appropriate normalization the largest eigenvalue of W N converges weakly to the type 2 Tracy-Widom distribution TW2 . Moreover, in the real case, we show that whenΣ is spiked with a fixed number of subcritical spikes, the type 1 Tracy-Widom limit TW1 holds for the normalized largest eigenvalue of W N , which extends a result of Féral and Péché in [J. Math. Phys. 50 (2009) 073302] to the scenario of nondiagonal Σ and more generally distributed X . In summary, we establish the Tracy-Widom type universality for the largest eigenvalue of generally distributed sample covariance matrices under quite light assumptions on &amp;Sigma . Applications of these limiting results to statistical signal detection and structure recognition of separable covariance matrices are also discussed.","lang":"eng"}],"month":"02","volume":43,"external_id":{"arxiv":["1304.5690"],"isi":["000349738500014"]},"publication_status":"published","author":[{"first_name":"Zhigang","last_name":"Bao","orcid":"0000-0003-3036-1475","full_name":"Bao, Zhigang","id":"442E6A6C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Pan, Guangming","first_name":"Guangming","last_name":"Pan"},{"full_name":"Zhou, Wang","last_name":"Zhou","first_name":"Wang"}],"_id":"1505","title":"Universality for the largest eigenvalue of sample covariance matrices with general population","citation":{"apa":"Bao, Z., Pan, G., &#38; Zhou, W. (2015). Universality for the largest eigenvalue of sample covariance matrices with general population. <i>Annals of Statistics</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/14-AOS1281\">https://doi.org/10.1214/14-AOS1281</a>","mla":"Bao, Zhigang, et al. “Universality for the Largest Eigenvalue of Sample Covariance Matrices with General Population.” <i>Annals of Statistics</i>, vol. 43, no. 1, Institute of Mathematical Statistics, 2015, pp. 382–421, doi:<a href=\"https://doi.org/10.1214/14-AOS1281\">10.1214/14-AOS1281</a>.","ieee":"Z. Bao, G. Pan, and W. Zhou, “Universality for the largest eigenvalue of sample covariance matrices with general population,” <i>Annals of Statistics</i>, vol. 43, no. 1. Institute of Mathematical Statistics, pp. 382–421, 2015.","ama":"Bao Z, Pan G, Zhou W. Universality for the largest eigenvalue of sample covariance matrices with general population. <i>Annals of Statistics</i>. 2015;43(1):382-421. doi:<a href=\"https://doi.org/10.1214/14-AOS1281\">10.1214/14-AOS1281</a>","ista":"Bao Z, Pan G, Zhou W. 2015. Universality for the largest eigenvalue of sample covariance matrices with general population. Annals of Statistics. 43(1), 382–421.","chicago":"Bao, Zhigang, Guangming Pan, and Wang Zhou. “Universality for the Largest Eigenvalue of Sample Covariance Matrices with General Population.” <i>Annals of Statistics</i>. Institute of Mathematical Statistics, 2015. <a href=\"https://doi.org/10.1214/14-AOS1281\">https://doi.org/10.1214/14-AOS1281</a>.","short":"Z. Bao, G. Pan, W. Zhou, Annals of Statistics 43 (2015) 382–421."},"publication":"Annals of Statistics","department":[{"_id":"LaEr"}],"publisher":"Institute of Mathematical Statistics","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1304.5690"}],"day":"01","date_updated":"2025-09-29T11:02:34Z","page":"382 - 421","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa_version":"Preprint","quality_controlled":"1","doi":"10.1214/14-AOS1281","status":"public","type":"journal_article","article_processing_charge":"No","arxiv":1},{"abstract":[{"text":"Consider the square random matrix An = (aij)n,n, where {aij:= a(n)ij , i, j = 1, . . . , n} is a collection of independent real random variables with means zero and variances one. Under the additional moment condition supn max1≤i,j ≤n Ea4ij &lt;∞, we prove Girko's logarithmic law of det An in the sense that as n→∞ log | detAn| ? (1/2) log(n-1)! d/→√(1/2) log n N(0, 1).","lang":"eng"}],"month":"08","volume":21,"date_published":"2015-08-01T00:00:00Z","publist_id":"5671","year":"2015","date_created":"2018-12-11T11:52:25Z","language":[{"iso":"eng"}],"oa":1,"issue":"3","isi":1,"intvolume":"        21","external_id":{"isi":["000356993100012"],"arxiv":["1208.5823"]},"publication_status":"published","author":[{"id":"442E6A6C-F248-11E8-B48F-1D18A9856A87","full_name":"Bao, Zhigang","orcid":"0000-0003-3036-1475","last_name":"Bao","first_name":"Zhigang"},{"first_name":"Guangming","last_name":"Pan","full_name":"Pan, Guangming"},{"last_name":"Zhou","first_name":"Wang","full_name":"Zhou, Wang"}],"day":"01","date_updated":"2025-09-23T13:59:56Z","_id":"1506","title":"The logarithmic law of random determinant","publication":"Bernoulli","citation":{"ista":"Bao Z, Pan G, Zhou W. 2015. The logarithmic law of random determinant. Bernoulli. 21(3), 1600–1628.","chicago":"Bao, Zhigang, Guangming Pan, and Wang Zhou. “The Logarithmic Law of Random Determinant.” <i>Bernoulli</i>. Bernoulli Society for Mathematical Statistics and Probability, 2015. <a href=\"https://doi.org/10.3150/14-BEJ615\">https://doi.org/10.3150/14-BEJ615</a>.","short":"Z. Bao, G. Pan, W. Zhou, Bernoulli 21 (2015) 1600–1628.","apa":"Bao, Z., Pan, G., &#38; Zhou, W. (2015). The logarithmic law of random determinant. <i>Bernoulli</i>. Bernoulli Society for Mathematical Statistics and Probability. <a href=\"https://doi.org/10.3150/14-BEJ615\">https://doi.org/10.3150/14-BEJ615</a>","mla":"Bao, Zhigang, et al. “The Logarithmic Law of Random Determinant.” <i>Bernoulli</i>, vol. 21, no. 3, Bernoulli Society for Mathematical Statistics and Probability, 2015, pp. 1600–28, doi:<a href=\"https://doi.org/10.3150/14-BEJ615\">10.3150/14-BEJ615</a>.","ieee":"Z. Bao, G. Pan, and W. Zhou, “The logarithmic law of random determinant,” <i>Bernoulli</i>, vol. 21, no. 3. Bernoulli Society for Mathematical Statistics and Probability, pp. 1600–1628, 2015.","ama":"Bao Z, Pan G, Zhou W. The logarithmic law of random determinant. <i>Bernoulli</i>. 2015;21(3):1600-1628. doi:<a href=\"https://doi.org/10.3150/14-BEJ615\">10.3150/14-BEJ615</a>"},"main_file_link":[{"url":"http://arxiv.org/abs/1208.5823","open_access":"1"}],"publisher":"Bernoulli Society for Mathematical Statistics and Probability","department":[{"_id":"LaEr"}],"type":"journal_article","arxiv":1,"article_processing_charge":"No","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa_version":"Preprint","page":"1600 - 1628","doi":"10.3150/14-BEJ615","quality_controlled":"1","status":"public"},{"type":"journal_article","article_processing_charge":"No","arxiv":1,"quality_controlled":"1","doi":"10.4171/JEMS/548","status":"public","page":"1927 - 2036","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa_version":"Preprint","scopus_import":"1","date_updated":"2025-09-23T09:08:38Z","day":"01","citation":{"ama":"Erdös L, Yau H. Gap universality of generalized Wigner and β ensembles. <i>Journal of the European Mathematical Society</i>. 2015;17(8):1927-2036. doi:<a href=\"https://doi.org/10.4171/JEMS/548\">10.4171/JEMS/548</a>","mla":"Erdös, László, and Horng Yau. “Gap Universality of Generalized Wigner and β Ensembles.” <i>Journal of the European Mathematical Society</i>, vol. 17, no. 8, European Mathematical Society, 2015, pp. 1927–2036, doi:<a href=\"https://doi.org/10.4171/JEMS/548\">10.4171/JEMS/548</a>.","apa":"Erdös, L., &#38; Yau, H. (2015). Gap universality of generalized Wigner and β ensembles. <i>Journal of the European Mathematical Society</i>. European Mathematical Society. <a href=\"https://doi.org/10.4171/JEMS/548\">https://doi.org/10.4171/JEMS/548</a>","ieee":"L. Erdös and H. Yau, “Gap universality of generalized Wigner and β ensembles,” <i>Journal of the European Mathematical Society</i>, vol. 17, no. 8. European Mathematical Society, pp. 1927–2036, 2015.","short":"L. Erdös, H. Yau, Journal of the European Mathematical Society 17 (2015) 1927–2036.","ista":"Erdös L, Yau H. 2015. Gap universality of generalized Wigner and β ensembles. Journal of the European Mathematical Society. 17(8), 1927–2036.","chicago":"Erdös, László, and Horng Yau. “Gap Universality of Generalized Wigner and β Ensembles.” <i>Journal of the European Mathematical Society</i>. European Mathematical Society, 2015. <a href=\"https://doi.org/10.4171/JEMS/548\">https://doi.org/10.4171/JEMS/548</a>."},"publication":"Journal of the European Mathematical Society","department":[{"_id":"LaEr"}],"publisher":"European Mathematical Society","main_file_link":[{"url":"http://arxiv.org/abs/1211.3786","open_access":"1"}],"title":"Gap universality of generalized Wigner and β ensembles","_id":"1508","author":[{"last_name":"Erdös","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","full_name":"Erdös, László"},{"last_name":"Yau","first_name":"Horng","full_name":"Yau, Horng"}],"external_id":{"isi":["000360822900003"],"arxiv":["1211.3786"]},"publication_status":"published","volume":17,"abstract":[{"lang":"eng","text":"We consider generalized Wigner ensembles and general β-ensembles with analytic potentials for any β ≥ 1. The recent universality results in particular assert that the local averages of consecutive eigenvalue gaps in the bulk of the spectrum are universal in the sense that they coincide with those of the corresponding Gaussian β-ensembles. In this article, we show that local averaging is not necessary for this result, i.e. we prove that the single gap distributions in the bulk are universal. In fact, with an additional step, our result can be extended to any C4(ℝ) potential."}],"month":"08","issue":"8","language":[{"iso":"eng"}],"oa":1,"isi":1,"intvolume":"        17","year":"2015","publist_id":"5669","date_published":"2015-08-01T00:00:00Z","date_created":"2018-12-11T11:52:26Z"},{"project":[{"_id":"25716A02-B435-11E9-9278-68D0E5697425","grant_number":"282300","call_identifier":"FP7","name":"Polarity and subcellular dynamics in plants"}],"corr_author":"1","publication_status":"published","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"pubrep_id":"497","author":[{"last_name":"Michalko","first_name":"Jaroslav","id":"483727CA-F248-11E8-B48F-1D18A9856A87","full_name":"Michalko, Jaroslav"},{"id":"4342E402-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2519-8004","full_name":"Dravecka, Marta","last_name":"Dravecka","first_name":"Marta"},{"orcid":"0000-0003-4398-476X","full_name":"Bollenbach, Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","first_name":"Tobias","last_name":"Bollenbach"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jirí"}],"date_published":"2015-10-01T00:00:00Z","file_date_updated":"2020-07-14T12:44:59Z","year":"2015","publist_id":"5668","date_created":"2018-12-11T11:52:26Z","language":[{"iso":"eng"}],"oa":1,"acknowledgement":"This work was supported by ERC Independent Research grant (ERC-2011-StG-20101109-PSDP to JF). JM internship was supported by the grant “Action Austria – Slovakia”.\r\nData associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication). \r\n\r\nData availability: \r\nF1000Research: Dataset 1. Dataset 1, 10.5256/f1000research.7143.d104552\r\n\r\nF1000Research: Dataset 2. Dataset 2, 10.5256/f1000research.7143.d104553\r\n\r\nF1000Research: Dataset 3. Dataset 3, 10.5256/f1000research.7143.d104554","intvolume":"         4","abstract":[{"lang":"eng","text":"The Auxin Binding Protein1 (ABP1) has been identified based on its ability to bind auxin with high affinity and studied for a long time as a prime candidate for the extracellular auxin receptor responsible for mediating in particular the fast non-transcriptional auxin responses. However, the contradiction between the embryo-lethal phenotypes of the originally described Arabidopsis T-DNA insertional knock-out alleles (abp1-1 and abp1-1s) and the wild type-like phenotypes of other recently described loss-of-function alleles (abp1-c1 and abp1-TD1) questions the biological importance of ABP1 and relevance of the previous genetic studies. Here we show that there is no hidden copy of the ABP1 gene in the Arabidopsis genome but the embryo-lethal phenotypes of abp1-1 and abp1-1s alleles are very similar to the knock-out phenotypes of the neighboring gene, BELAYA SMERT (BSM). Furthermore, the allelic complementation test between bsm and abp1 alleles shows that the embryo-lethality in the abp1-1 and abp1-1s alleles is caused by the off-target disruption of the BSM locus by the T-DNA insertions. This clarifies the controversy of different phenotypes among published abp1 knock-out alleles and asks for reflections on the developmental role of ABP1."}],"month":"10","volume":4,"oa_version":"Published Version","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.12688/f1000research.7143.1","quality_controlled":"1","status":"public","ec_funded":1,"type":"journal_article","article_processing_charge":"No","ddc":["570"],"title":"Embryo-lethal phenotypes in early abp1 mutants are due to disruption of the neighboring BSM gene","_id":"1509","has_accepted_license":"1","publication":"F1000 Research ","citation":{"chicago":"Michalko, Jaroslav, Marta Lukacisinova, Mark Tobias Bollenbach, and Jiří Friml. “Embryo-Lethal Phenotypes in Early Abp1 Mutants Are Due to Disruption of the Neighboring BSM Gene.” <i>F1000 Research </i>. F1000 Research, 2015. <a href=\"https://doi.org/10.12688/f1000research.7143.1\">https://doi.org/10.12688/f1000research.7143.1</a>.","ista":"Michalko J, Lukacisinova M, Bollenbach MT, Friml J. 2015. Embryo-lethal phenotypes in early abp1 mutants are due to disruption of the neighboring BSM gene. F1000 Research . 4.","short":"J. Michalko, M. Lukacisinova, M.T. Bollenbach, J. Friml, F1000 Research  4 (2015).","ieee":"J. Michalko, M. Lukacisinova, M. T. Bollenbach, and J. Friml, “Embryo-lethal phenotypes in early abp1 mutants are due to disruption of the neighboring BSM gene,” <i>F1000 Research </i>, vol. 4. F1000 Research, 2015.","mla":"Michalko, Jaroslav, et al. “Embryo-Lethal Phenotypes in Early Abp1 Mutants Are Due to Disruption of the Neighboring BSM Gene.” <i>F1000 Research </i>, vol. 4, F1000 Research, 2015, doi:<a href=\"https://doi.org/10.12688/f1000research.7143.1\">10.12688/f1000research.7143.1</a>.","apa":"Michalko, J., Lukacisinova, M., Bollenbach, M. T., &#38; Friml, J. (2015). Embryo-lethal phenotypes in early abp1 mutants are due to disruption of the neighboring BSM gene. <i>F1000 Research </i>. F1000 Research. <a href=\"https://doi.org/10.12688/f1000research.7143.1\">https://doi.org/10.12688/f1000research.7143.1</a>","ama":"Michalko J, Lukacisinova M, Bollenbach MT, Friml J. Embryo-lethal phenotypes in early abp1 mutants are due to disruption of the neighboring BSM gene. <i>F1000 Research </i>. 2015;4. doi:<a href=\"https://doi.org/10.12688/f1000research.7143.1\">10.12688/f1000research.7143.1</a>"},"file":[{"content_type":"application/pdf","file_size":4414248,"creator":"system","access_level":"open_access","date_created":"2018-12-12T10:16:12Z","relation":"main_file","date_updated":"2020-07-14T12:44:59Z","file_name":"IST-2016-497-v1+1_10.12688_f1000research.7143.1_20151102.pdf","file_id":"5198","checksum":"8beae5cbe988e1060265ae7de2ee8306"}],"department":[{"_id":"JiFr"},{"_id":"ToBo"}],"publisher":"F1000 Research","day":"01","date_updated":"2025-04-15T07:48:03Z"},{"project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme"}],"author":[{"id":"473294AE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8878-8397","full_name":"Franek, Peter","last_name":"Franek","first_name":"Peter"},{"id":"33E21118-F248-11E8-B48F-1D18A9856A87","full_name":"Krcál, Marek","last_name":"Krcál","first_name":"Marek"}],"publication_status":"published","pubrep_id":"503","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"intvolume":"        34","oa":1,"language":[{"iso":"eng"}],"date_created":"2018-12-11T11:52:26Z","file_date_updated":"2020-07-14T12:44:59Z","date_published":"2015-06-11T00:00:00Z","year":"2015","publist_id":"5667","volume":34,"month":"06","abstract":[{"text":"The concept of well group in a special but important case captures homological properties of the zero set of a continuous map f from K to R^n on a compact space K that are invariant with respect to perturbations of f. The perturbations are arbitrary continuous maps within L_infty distance r from f for a given r &gt; 0. The main drawback of the approach is that the computability of well groups was shown only when dim K = n or n = 1. Our contribution to the theory of well groups is twofold: on the one hand we improve on the computability issue, but on the other hand we present a range of examples where the well groups are incomplete invariants, that is, fail to capture certain important robust properties of the zero set. For the first part, we identify a computable subgroup of the well group that is obtained by cap product with the pullback of the orientation of R^n by f. In other words, well groups can be algorithmically approximated from below. When f is smooth and dim K &lt; 2n-2, our approximation of the (dim K-n)th well group is exact. For the second part, we find examples of maps f, f' from K to R^n with all well groups isomorphic but whose perturbations have different zero sets. We discuss on a possible replacement of the well groups of vector valued maps by an invariant of a better descriptive power and computability status. ","lang":"eng"}],"ec_funded":1,"status":"public","doi":"10.4230/LIPIcs.SOCG.2015.842","quality_controlled":"1","conference":{"end_date":"2015-06-25","location":"Eindhoven, Netherlands","start_date":"2015-06-22","name":"SoCG: Symposium on Computational Geometry"},"oa_version":"Published Version","scopus_import":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"status":"public","relation":"later_version","id":"1408"}]},"page":"842 - 856","ddc":["510"],"type":"conference","file":[{"file_id":"5001","checksum":"49eb5021caafaabe5356c65b9c5f8c9c","date_updated":"2020-07-14T12:44:59Z","file_name":"IST-2016-503-v1+1_32.pdf","access_level":"open_access","date_created":"2018-12-12T10:13:19Z","relation":"main_file","content_type":"application/pdf","file_size":623563,"creator":"system"}],"department":[{"_id":"UlWa"},{"_id":"HeEd"}],"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","has_accepted_license":"1","citation":{"ama":"Franek P, Krcál M. On computability and triviality of well groups. In: Vol 34. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2015:842-856. doi:<a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.842\">10.4230/LIPIcs.SOCG.2015.842</a>","ieee":"P. Franek and M. Krcál, “On computability and triviality of well groups,” presented at the SoCG: Symposium on Computational Geometry, Eindhoven, Netherlands, 2015, vol. 34, pp. 842–856.","apa":"Franek, P., &#38; Krcál, M. (2015). On computability and triviality of well groups (Vol. 34, pp. 842–856). Presented at the SoCG: Symposium on Computational Geometry, Eindhoven, Netherlands: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.842\">https://doi.org/10.4230/LIPIcs.SOCG.2015.842</a>","mla":"Franek, Peter, and Marek Krcál. <i>On Computability and Triviality of Well Groups</i>. Vol. 34, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015, pp. 842–56, doi:<a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.842\">10.4230/LIPIcs.SOCG.2015.842</a>.","short":"P. Franek, M. Krcál, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015, pp. 842–856.","chicago":"Franek, Peter, and Marek Krcál. “On Computability and Triviality of Well Groups,” 34:842–56. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015. <a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.842\">https://doi.org/10.4230/LIPIcs.SOCG.2015.842</a>.","ista":"Franek P, Krcál M. 2015. On computability and triviality of well groups. SoCG: Symposium on Computational Geometry, LIPIcs, vol. 34, 842–856."},"_id":"1510","title":"On computability and triviality of well groups","date_updated":"2025-09-18T14:30:52Z","day":"11","alternative_title":["LIPIcs"]},{"publication_status":"published","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"pubrep_id":"502","author":[{"first_name":"Xavier","last_name":"Goaoc","full_name":"Goaoc, Xavier"},{"last_name":"Mabillard","first_name":"Isaac","id":"32BF9DAA-F248-11E8-B48F-1D18A9856A87","full_name":"Mabillard, Isaac"},{"full_name":"Paták, Pavel","last_name":"Paták","first_name":"Pavel"},{"id":"48B57058-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3975-1683","full_name":"Patakova, Zuzana","last_name":"Patakova","first_name":"Zuzana"},{"id":"38AC689C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1191-6714","full_name":"Tancer, Martin","last_name":"Tancer","first_name":"Martin"},{"full_name":"Wagner, Uli","orcid":"0000-0002-1494-0568","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","first_name":"Uli","last_name":"Wagner"}],"project":[{"name":"International IST Postdoc Fellowship Programme","grant_number":"291734","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425"}],"month":"06","abstract":[{"text":"The fact that the complete graph K_5 does not embed in the plane has been generalized in two independent directions. On the one hand, the solution of the classical Heawood problem for graphs on surfaces established that the complete graph K_n embeds in a closed surface M if and only if (n-3)(n-4) is at most 6b_1(M), where b_1(M) is the first Z_2-Betti number of M. On the other hand, Van Kampen and Flores proved that the k-skeleton of the n-dimensional simplex (the higher-dimensional analogue of K_{n+1}) embeds in R^{2k} if and only if n is less or equal to 2k+2. Two decades ago, Kuhnel conjectured that the k-skeleton of the n-simplex embeds in a compact, (k-1)-connected 2k-manifold with kth Z_2-Betti number b_k only if the following generalized Heawood inequality holds: binom{n-k-1}{k+1} is at most binom{2k+1}{k+1} b_k. This is a common generalization of the case of graphs on surfaces as well as the Van Kampen--Flores theorem. In the spirit of Kuhnel's conjecture, we prove that if the k-skeleton of the n-simplex embeds in a 2k-manifold with kth Z_2-Betti number b_k, then n is at most 2b_k binom{2k+2}{k} + 2k + 5. This bound is weaker than the generalized Heawood inequality, but does not require the assumption that M is (k-1)-connected. Our proof uses a result of Volovikov about maps that satisfy a certain homological triviality condition.","lang":"eng"}],"volume":"34 ","date_created":"2018-12-11T11:52:27Z","file_date_updated":"2020-07-14T12:44:59Z","date_published":"2015-06-11T00:00:00Z","year":"2015","publist_id":"5666","oa":1,"language":[{"iso":"eng"}],"acknowledgement":"The work by Z. P. was partially supported by the Charles University Grant SVV-2014-260103. The\r\nwork by Z. P. and M. T. was partially supported by the project CE-ITI (GACR P202/12/G061) of\r\nthe Czech Science Foundation and by the ERC Advanced Grant No. 267165. Part of the research\r\nwork of M. T. was conducted at IST Austria, supported by an IST Fellowship. The work by U.W.\r\nwas partially supported by the Swiss National Science Foundation (grants SNSF-200020-138230 and\r\nSNSF-PP00P2-138948).","type":"conference","ddc":["510"],"conference":{"location":"Eindhoven, Netherlands","name":"SoCG: Symposium on Computational Geometry","start_date":"2015-06-22","end_date":"2015-06-25"},"oa_version":"Published Version","scopus_import":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"id":"610","relation":"later_version","status":"public"}]},"page":"476 - 490","ec_funded":1,"status":"public","doi":"10.4230/LIPIcs.SOCG.2015.476","quality_controlled":"1","day":"11","alternative_title":["LIPIcs"],"date_updated":"2025-09-11T07:35:35Z","_id":"1511","title":"On generalized Heawood inequalities for manifolds: A Van Kampen–Flores-type nonembeddability result","file":[{"access_level":"open_access","relation":"main_file","date_created":"2018-12-12T10:11:18Z","file_size":636735,"content_type":"application/pdf","creator":"system","file_id":"4871","checksum":"0945811875351796324189312ca29e9e","date_updated":"2020-07-14T12:44:59Z","file_name":"IST-2016-502-v1+1_42.pdf"}],"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","department":[{"_id":"UlWa"}],"has_accepted_license":"1","citation":{"short":"X. Goaoc, I. Mabillard, P. Paták, Z. Patakova, M. Tancer, U. Wagner, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015, pp. 476–490.","chicago":"Goaoc, Xavier, Isaac Mabillard, Pavel Paták, Zuzana Patakova, Martin Tancer, and Uli Wagner. “On Generalized Heawood Inequalities for Manifolds: A Van Kampen–Flores-Type Nonembeddability Result,” 34:476–90. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015. <a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.476\">https://doi.org/10.4230/LIPIcs.SOCG.2015.476</a>.","ista":"Goaoc X, Mabillard I, Paták P, Patakova Z, Tancer M, Wagner U. 2015. On generalized Heawood inequalities for manifolds: A Van Kampen–Flores-type nonembeddability result. SoCG: Symposium on Computational Geometry, LIPIcs, vol. 34, 476–490.","ama":"Goaoc X, Mabillard I, Paták P, Patakova Z, Tancer M, Wagner U. On generalized Heawood inequalities for manifolds: A Van Kampen–Flores-type nonembeddability result. In: Vol 34. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2015:476-490. doi:<a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.476\">10.4230/LIPIcs.SOCG.2015.476</a>","ieee":"X. Goaoc, I. Mabillard, P. Paták, Z. Patakova, M. Tancer, and U. Wagner, “On generalized Heawood inequalities for manifolds: A Van Kampen–Flores-type nonembeddability result,” presented at the SoCG: Symposium on Computational Geometry, Eindhoven, Netherlands, 2015, vol. 34, pp. 476–490.","apa":"Goaoc, X., Mabillard, I., Paták, P., Patakova, Z., Tancer, M., &#38; Wagner, U. (2015). On generalized Heawood inequalities for manifolds: A Van Kampen–Flores-type nonembeddability result (Vol. 34, pp. 476–490). Presented at the SoCG: Symposium on Computational Geometry, Eindhoven, Netherlands: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.476\">https://doi.org/10.4230/LIPIcs.SOCG.2015.476</a>","mla":"Goaoc, Xavier, et al. <i>On Generalized Heawood Inequalities for Manifolds: A Van Kampen–Flores-Type Nonembeddability Result</i>. Vol. 34, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015, pp. 476–90, doi:<a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.476\">10.4230/LIPIcs.SOCG.2015.476</a>."}},{"alternative_title":["LIPIcs"],"day":"01","date_updated":"2026-06-18T18:48:48Z","_id":"1512","title":"Bounding Helly numbers via Betti numbers","department":[{"_id":"UlWa"}],"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","file":[{"date_updated":"2020-07-14T12:45:00Z","file_name":"IST-2016-501-v1+1_46.pdf","file_id":"4794","checksum":"e6881df44d87fe0c2529c9f7b2724614","file_size":633712,"content_type":"application/pdf","creator":"system","access_level":"open_access","relation":"main_file","date_created":"2018-12-12T10:10:09Z"}],"citation":{"ieee":"X. Goaoc, P. Paták, Z. Patakova, M. Tancer, and U. Wagner, “Bounding Helly numbers via Betti numbers,” presented at the SoCG: Symposium on Computational Geometry, Eindhoven, Netherlands, 2015, vol. 34, pp. 507–521.","apa":"Goaoc, X., Paták, P., Patakova, Z., Tancer, M., &#38; Wagner, U. (2015). Bounding Helly numbers via Betti numbers (Vol. 34, pp. 507–521). Presented at the SoCG: Symposium on Computational Geometry, Eindhoven, Netherlands: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.507\">https://doi.org/10.4230/LIPIcs.SOCG.2015.507</a>","mla":"Goaoc, Xavier, et al. <i>Bounding Helly Numbers via Betti Numbers</i>. Vol. 34, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015, pp. 507–21, doi:<a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.507\">10.4230/LIPIcs.SOCG.2015.507</a>.","ama":"Goaoc X, Paták P, Patakova Z, Tancer M, Wagner U. Bounding Helly numbers via Betti numbers. In: Vol 34. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2015:507-521. doi:<a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.507\">10.4230/LIPIcs.SOCG.2015.507</a>","chicago":"Goaoc, Xavier, Pavel Paták, Zuzana Patakova, Martin Tancer, and Uli Wagner. “Bounding Helly Numbers via Betti Numbers,” 34:507–21. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015. <a href=\"https://doi.org/10.4230/LIPIcs.SOCG.2015.507\">https://doi.org/10.4230/LIPIcs.SOCG.2015.507</a>.","ista":"Goaoc X, Paták P, Patakova Z, Tancer M, Wagner U. 2015. Bounding Helly numbers via Betti numbers. SoCG: Symposium on Computational Geometry, LIPIcs, vol. 34, 507–521.","short":"X. Goaoc, P. Paták, Z. Patakova, M. Tancer, U. Wagner, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015, pp. 507–521."},"has_accepted_license":"1","article_processing_charge":"No","type":"conference","ddc":["510"],"conference":{"name":"SoCG: Symposium on Computational Geometry","start_date":"2015-06-22","location":"Eindhoven, Netherlands","end_date":"2015-06-25"},"related_material":{"record":[{"id":"424","relation":"later_version","status":"public"}]},"page":"507 - 521","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Submitted Version","status":"public","quality_controlled":"1","doi":"10.4230/LIPIcs.SOCG.2015.507","month":"01","abstract":[{"lang":"eng","text":"We show that very weak topological assumptions are enough to ensure the existence of a Helly-type theorem. More precisely, we show that for any non-negative integers b and d there exists an integer h(b,d) such that the following holds. If F is a finite family of subsets of R^d such that the ith reduced Betti number (with Z_2 coefficients in singular homology) of the intersection of any proper subfamily G of F is at most b for every non-negative integer i less or equal to (d-1)/2, then F has Helly number at most h(b,d). These topological conditions are sharp: not controlling any of these first Betti numbers allow for families with unbounded Helly number. Our proofs combine homological non-embeddability results with a Ramsey-based approach to build, given an arbitrary simplicial complex K, some well-behaved chain map from C_*(K) to C_*(R^d). Both techniques are of independent interest."}],"volume":34,"date_created":"2018-12-11T11:52:27Z","year":"2015","publist_id":"5665","file_date_updated":"2020-07-14T12:45:00Z","date_published":"2015-01-01T00:00:00Z","intvolume":"        34","acknowledgement":"PP, ZP and MT were partially supported by the Charles University Grant GAUK 421511. ZP was\r\npartially supported by the Charles University Grant SVV-2014-260103. ZP and MT were partially\r\nsupported by the ERC Advanced Grant No. 267165 and by the project CE-ITI (GACR P202/12/G061)\r\nof the Czech Science Foundation. UW was partially supported by the Swiss National Science Foundation\r\n(grants SNSF-200020-138230 and SNSF-PP00P2-138948). Part of this work was done when XG was affiliated with INRIA Nancy Grand-Est and when MT was affiliated with Institutionen för matematik, Kungliga Tekniska Högskolan, then IST Austria.","oa":1,"language":[{"iso":"eng"}],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"pubrep_id":"501","publication_status":"published","author":[{"full_name":"Goaoc, Xavier","first_name":"Xavier","last_name":"Goaoc"},{"full_name":"Paták, Pavel","last_name":"Paták","first_name":"Pavel"},{"full_name":"Patakova, Zuzana","orcid":"0000-0002-3975-1683","first_name":"Zuzana","last_name":"Patakova"},{"first_name":"Martin","last_name":"Tancer","orcid":"0000-0002-1191-6714","full_name":"Tancer, Martin"},{"full_name":"Wagner, Uli","orcid":"0000-0002-1494-0568","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","first_name":"Uli","last_name":"Wagner"}]},{"ddc":["570"],"type":"journal_article","article_processing_charge":"No","quality_controlled":"1","doi":"10.1093/gbe/evv215","status":"public","ec_funded":1,"page":"3259 - 3268","oa_version":"Published Version","scopus_import":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2025-09-23T14:18:15Z","day":"01","citation":{"ista":"Pal A, Vicoso B. 2015. The X chromosome of hemipteran insects: Conservation, dosage compensation and sex-biased expression. Genome Biology and Evolution. 7(12), 3259–3268.","chicago":"Pal, Arka, and Beatriz Vicoso. “The X Chromosome of Hemipteran Insects: Conservation, Dosage Compensation and Sex-Biased Expression.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2015. <a href=\"https://doi.org/10.1093/gbe/evv215\">https://doi.org/10.1093/gbe/evv215</a>.","short":"A. Pal, B. Vicoso, Genome Biology and Evolution 7 (2015) 3259–3268.","mla":"Pal, Arka, and Beatriz Vicoso. “The X Chromosome of Hemipteran Insects: Conservation, Dosage Compensation and Sex-Biased Expression.” <i>Genome Biology and Evolution</i>, vol. 7, no. 12, Oxford University Press, 2015, pp. 3259–68, doi:<a href=\"https://doi.org/10.1093/gbe/evv215\">10.1093/gbe/evv215</a>.","apa":"Pal, A., &#38; Vicoso, B. (2015). The X chromosome of hemipteran insects: Conservation, dosage compensation and sex-biased expression. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evv215\">https://doi.org/10.1093/gbe/evv215</a>","ieee":"A. Pal and B. Vicoso, “The X chromosome of hemipteran insects: Conservation, dosage compensation and sex-biased expression,” <i>Genome Biology and Evolution</i>, vol. 7, no. 12. Oxford University Press, pp. 3259–3268, 2015.","ama":"Pal A, Vicoso B. The X chromosome of hemipteran insects: Conservation, dosage compensation and sex-biased expression. <i>Genome Biology and Evolution</i>. 2015;7(12):3259-3268. doi:<a href=\"https://doi.org/10.1093/gbe/evv215\">10.1093/gbe/evv215</a>"},"has_accepted_license":"1","publication":"Genome Biology and Evolution","publisher":"Oxford University Press","department":[{"_id":"BeVi"}],"file":[{"date_created":"2018-12-12T10:17:29Z","relation":"main_file","access_level":"open_access","creator":"system","content_type":"application/pdf","file_size":858027,"file_id":"5284","checksum":"2b56b8c2e2a1d4cc3c9cb8daba26dd9b","file_name":"IST-2016-496-v1+1_Genome_Biol_Evol-2015-Pal-3259-68.pdf","date_updated":"2020-07-14T12:45:00Z"}],"_id":"1513","title":"The X chromosome of hemipteran insects: Conservation, dosage compensation and sex-biased expression","author":[{"orcid":"0000-0002-4530-8469","full_name":"Pal, Arka","id":"6AAB2240-CA9A-11E9-9C1A-D9D1E5697425","first_name":"Arka","last_name":"Pal"},{"full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","last_name":"Vicoso"}],"corr_author":"1","external_id":{"isi":["000366498700008"]},"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"pubrep_id":"496","publication_status":"published","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","grant_number":"291734","call_identifier":"FP7"}],"volume":7,"abstract":[{"text":"Insects of the order Hemiptera (true bugs) use a wide range of mechanisms of sex determination, including genetic sex determination, paternal genome elimination, and haplodiploidy. Genetic sex determination, the prevalent mode, is generally controlled by a pair of XY sex chromosomes or by an XX/X0 system, but different configurations that include additional sex chromosomes are also present. Although this diversity of sex determining systems has been extensively studied at the cytogenetic level, only the X chromosome of the model pea aphid Acyrthosiphon pisum has been analyzed at the genomic level, and little is known about X chromosome biology in the rest of the order.\r\n\r\nIn this study, we take advantage of published DNA- and RNA-seq data from three additional Hemiptera species to perform a comparative analysis of the gene content and expression of the X chromosome throughout this clade. We find that, despite showing evidence of dosage compensation, the X chromosomes of these species show female-biased expression, and a deficit of male-biased genes, in direct contrast to the pea aphid X. We further detect an excess of shared gene content between these very distant species, suggesting that despite the diversity of sex determining systems, the same chromosomal element is used as the X throughout a large portion of the order. ","lang":"eng"}],"month":"12","isi":1,"oa":1,"issue":"12","language":[{"iso":"eng"}],"intvolume":"         7","publist_id":"5664","year":"2015","date_published":"2015-12-01T00:00:00Z","file_date_updated":"2020-07-14T12:45:00Z","date_created":"2018-12-11T11:52:27Z"},{"title":"Cancer/Testis antigen PASD1 silences the circadian clock","_id":"15160","publication":"Molecular Cell","keyword":["Cell Biology","Molecular Biology"],"citation":{"short":"A.K. Michael, S.L. Harvey, P.J. Sammons, A.P. Anderson, H.M. Kopalle, A.H. Banham, C.L. Partch, Molecular Cell 58 (2015) 743–754.","ista":"Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch CL. 2015. Cancer/Testis antigen PASD1 silences the circadian clock. Molecular Cell. 58(5), 743–754.","chicago":"Michael, Alicia K., Stacy L. Harvey, Patrick J. Sammons, Amanda P. Anderson, Hema M. Kopalle, Alison H. Banham, and Carrie L. Partch. “Cancer/Testis Antigen PASD1 Silences the Circadian Clock.” <i>Molecular Cell</i>. Elsevier, 2015. <a href=\"https://doi.org/10.1016/j.molcel.2015.03.031\">https://doi.org/10.1016/j.molcel.2015.03.031</a>.","ama":"Michael AK, Harvey SL, Sammons PJ, et al. Cancer/Testis antigen PASD1 silences the circadian clock. <i>Molecular Cell</i>. 2015;58(5):743-754. doi:<a href=\"https://doi.org/10.1016/j.molcel.2015.03.031\">10.1016/j.molcel.2015.03.031</a>","mla":"Michael, Alicia K., et al. “Cancer/Testis Antigen PASD1 Silences the Circadian Clock.” <i>Molecular Cell</i>, vol. 58, no. 5, Elsevier, 2015, pp. 743–54, doi:<a href=\"https://doi.org/10.1016/j.molcel.2015.03.031\">10.1016/j.molcel.2015.03.031</a>.","apa":"Michael, A. K., Harvey, S. L., Sammons, P. J., Anderson, A. P., Kopalle, H. M., Banham, A. H., &#38; Partch, C. L. (2015). Cancer/Testis antigen PASD1 silences the circadian clock. <i>Molecular Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.molcel.2015.03.031\">https://doi.org/10.1016/j.molcel.2015.03.031</a>","ieee":"A. K. Michael <i>et al.</i>, “Cancer/Testis antigen PASD1 silences the circadian clock,” <i>Molecular Cell</i>, vol. 58, no. 5. Elsevier, pp. 743–754, 2015."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.molcel.2015.03.031"}],"publisher":"Elsevier","day":"04","date_updated":"2024-03-25T11:52:26Z","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","page":"743-754","publication_identifier":{"issn":["1097-2765"]},"doi":"10.1016/j.molcel.2015.03.031","quality_controlled":"1","status":"public","extern":"1","type":"journal_article","article_processing_charge":"No","date_published":"2015-06-04T00:00:00Z","year":"2015","article_type":"original","date_created":"2024-03-21T07:58:08Z","language":[{"iso":"eng"}],"issue":"5","oa":1,"intvolume":"        58","abstract":[{"lang":"eng","text":"The circadian clock orchestrates global changes in transcriptional regulation on a daily basis via the bHLH-PAS transcription factor CLOCK:BMAL1. Pathways driven by other bHLH-PAS transcription factors have a homologous repressor that modulates activity on a tissue-specific basis, but none have been identified for CLOCK:BMAL1. We show here that the cancer/testis antigen PASD1 fulfills this role to suppress circadian rhythms. PASD1 is evolutionarily related to CLOCK and interacts with the CLOCK:BMAL1 complex to repress transcriptional activation. Expression of PASD1 is restricted to germline tissues in healthy individuals but can be induced in cells of somatic origin upon oncogenic transformation. Reducing PASD1 in human cancer cells significantly increases the amplitude of transcriptional oscillations to generate more robust circadian rhythms. Our results describe a function for a germline-specific protein in regulation of the circadian clock and provide a molecular link from oncogenic transformation to suppression of circadian rhythms."}],"month":"06","volume":58,"publication_status":"published","author":[{"last_name":"Michael","first_name":"Alicia Kathleen","id":"6437c950-2a03-11ee-914d-d6476dd7b75c","full_name":"Michael, Alicia Kathleen"},{"first_name":"Stacy L.","last_name":"Harvey","full_name":"Harvey, Stacy L."},{"full_name":"Sammons, Patrick J.","first_name":"Patrick J.","last_name":"Sammons"},{"first_name":"Amanda P.","last_name":"Anderson","full_name":"Anderson, Amanda P."},{"last_name":"Kopalle","first_name":"Hema M.","full_name":"Kopalle, Hema M."},{"full_name":"Banham, Alison H.","first_name":"Alison H.","last_name":"Banham"},{"first_name":"Carrie L.","last_name":"Partch","full_name":"Partch, Carrie L."}]},{"doi":"10.1214/ECP.v20-4315","quality_controlled":"1","status":"public","oa_version":"Published Version","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","scopus_import":"1","ddc":["519"],"type":"journal_article","article_processing_charge":"No","has_accepted_license":"1","publication":"Electronic Communications in Probability","citation":{"chicago":"Erbar, Matthias, Jan Maas, and Michiel Renger. “From Large Deviations to Wasserstein Gradient Flows in Multiple Dimensions.” <i>Electronic Communications in Probability</i>. Institute of Mathematical Statistics, 2015. <a href=\"https://doi.org/10.1214/ECP.v20-4315\">https://doi.org/10.1214/ECP.v20-4315</a>.","ista":"Erbar M, Maas J, Renger M. 2015. From large deviations to Wasserstein gradient flows in multiple dimensions. Electronic Communications in Probability. 20, 89.","short":"M. Erbar, J. Maas, M. Renger, Electronic Communications in Probability 20 (2015).","ieee":"M. Erbar, J. Maas, and M. Renger, “From large deviations to Wasserstein gradient flows in multiple dimensions,” <i>Electronic Communications in Probability</i>, vol. 20. Institute of Mathematical Statistics, 2015.","mla":"Erbar, Matthias, et al. “From Large Deviations to Wasserstein Gradient Flows in Multiple Dimensions.” <i>Electronic Communications in Probability</i>, vol. 20, 89, Institute of Mathematical Statistics, 2015, doi:<a href=\"https://doi.org/10.1214/ECP.v20-4315\">10.1214/ECP.v20-4315</a>.","apa":"Erbar, M., Maas, J., &#38; Renger, M. (2015). From large deviations to Wasserstein gradient flows in multiple dimensions. <i>Electronic Communications in Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/ECP.v20-4315\">https://doi.org/10.1214/ECP.v20-4315</a>","ama":"Erbar M, Maas J, Renger M. From large deviations to Wasserstein gradient flows in multiple dimensions. <i>Electronic Communications in Probability</i>. 2015;20. doi:<a href=\"https://doi.org/10.1214/ECP.v20-4315\">10.1214/ECP.v20-4315</a>"},"file":[{"checksum":"135741c17d3e1547ca696b6fbdcd559c","file_id":"4828","date_updated":"2020-07-14T12:45:00Z","file_name":"IST-2016-494-v1+1_4315-23820-1-PB.pdf","access_level":"open_access","relation":"main_file","date_created":"2018-12-12T10:10:39Z","file_size":230525,"content_type":"application/pdf","creator":"system"}],"department":[{"_id":"JaMa"}],"publisher":"Institute of Mathematical Statistics","_id":"1517","title":"From large deviations to Wasserstein gradient flows in multiple dimensions","date_updated":"2025-09-23T08:53:14Z","day":"29","author":[{"full_name":"Erbar, Matthias","first_name":"Matthias","last_name":"Erbar"},{"first_name":"Jan","last_name":"Maas","full_name":"Maas, Jan","orcid":"0000-0002-0845-1338","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Michiel","last_name":"Renger","full_name":"Renger, Michiel"}],"external_id":{"isi":["000365470700001"]},"publication_status":"published","article_number":"89","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"pubrep_id":"494","isi":1,"oa":1,"language":[{"iso":"eng"}],"intvolume":"        20","file_date_updated":"2020-07-14T12:45:00Z","date_published":"2015-11-29T00:00:00Z","publist_id":"5660","year":"2015","date_created":"2018-12-11T11:52:29Z","volume":20,"abstract":[{"lang":"eng","text":"We study the large deviation rate functional for the empirical distribution of independent Brownian particles with drift. In one dimension, it has been shown by Adams, Dirr, Peletier and Zimmer that this functional is asymptotically equivalent (in the sense of Γ-convergence) to the Jordan-Kinderlehrer-Otto functional arising in the Wasserstein gradient flow structure of the Fokker-Planck equation. In higher dimensions, part of this statement (the lower bound) has been recently proved by Duong, Laschos and Renger, but the upper bound remained open, since the proof of Duong et al relies on regularity properties of optimal transport maps that are restricted to one dimension. In this note we present a new proof of the upper bound, thereby generalising the result of Adams et al to arbitrary dimensions.\r\n"}],"month":"11"},{"intvolume":"        69","language":[{"iso":"eng"}],"isi":1,"issue":"5","oa":1,"date_created":"2018-12-11T11:52:29Z","file_date_updated":"2020-07-14T12:45:00Z","date_published":"2015-03-19T00:00:00Z","year":"2015","publist_id":"5656","volume":69,"month":"03","abstract":[{"lang":"eng","text":"Evolutionary biologists have an array of powerful theoretical techniques that can accurately predict changes in the genetic composition of populations. Changes in gene frequencies and genetic associations between loci can be tracked as they respond to a wide variety of evolutionary forces. However, it is often less clear how to decompose these various forces into components that accurately reflect the underlying biology. Here, we present several issues that arise in the definition and interpretation of selection and selection coefficients, focusing on insights gained through the examination of selection coefficients in multilocus notation. Using this notation, we discuss how its flexibility-which allows different biological units to be identified as targets of selection-is reflected in the interpretation of the coefficients that the notation generates. In many situations, it can be difficult to agree on whether loci can be considered to be under &quot;direct&quot; versus &quot;indirect&quot; selection, or to quantify this selection. We present arguments for what the terms direct and indirect selection might best encompass, considering a range of issues, from viability and sexual selection to kin selection. We show how multilocus notation can discriminate between direct and indirect selection, and describe when it can do so."}],"project":[{"grant_number":"250152","call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation","_id":"25B07788-B435-11E9-9278-68D0E5697425"}],"author":[{"last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240"},{"last_name":"Servedio","first_name":"Maria","full_name":"Servedio, Maria"}],"publication_status":"published","pubrep_id":"560","external_id":{"isi":["000354561600001"]},"corr_author":"1","file":[{"checksum":"fd8d23f476bc194419929b72ca265c02","file_id":"4822","file_name":"IST-2016-560-v1+1_Interpreting_ML_coefficients_11.2.15_App.pdf","date_updated":"2020-07-14T12:45:00Z","relation":"main_file","date_created":"2018-12-12T10:10:34Z","access_level":"open_access","creator":"system","file_size":188872,"content_type":"application/pdf"},{"date_created":"2018-12-12T10:10:35Z","relation":"main_file","access_level":"open_access","creator":"system","content_type":"application/pdf","file_size":577415,"checksum":"b774911e70044641d556e258efcb52ef","file_id":"4823","file_name":"IST-2016-560-v1+2_Interpreting_ML_coefficients_11.2.15_mainText.pdf","date_updated":"2020-07-14T12:45:00Z"}],"publisher":"Wiley","department":[{"_id":"NiBa"}],"has_accepted_license":"1","publication":"Evolution","citation":{"mla":"Barton, Nicholas H., and Maria Servedio. “The Interpretation of Selection Coefficients.” <i>Evolution</i>, vol. 69, no. 5, Wiley, 2015, pp. 1101–12, doi:<a href=\"https://doi.org/10.1111/evo.12641\">10.1111/evo.12641</a>.","apa":"Barton, N. H., &#38; Servedio, M. (2015). The interpretation of selection coefficients. <i>Evolution</i>. Wiley. <a href=\"https://doi.org/10.1111/evo.12641\">https://doi.org/10.1111/evo.12641</a>","ieee":"N. H. Barton and M. Servedio, “The interpretation of selection coefficients,” <i>Evolution</i>, vol. 69, no. 5. Wiley, pp. 1101–1112, 2015.","ama":"Barton NH, Servedio M. The interpretation of selection coefficients. <i>Evolution</i>. 2015;69(5):1101-1112. doi:<a href=\"https://doi.org/10.1111/evo.12641\">10.1111/evo.12641</a>","ista":"Barton NH, Servedio M. 2015. The interpretation of selection coefficients. Evolution. 69(5), 1101–1112.","chicago":"Barton, Nicholas H, and Maria Servedio. “The Interpretation of Selection Coefficients.” <i>Evolution</i>. Wiley, 2015. <a href=\"https://doi.org/10.1111/evo.12641\">https://doi.org/10.1111/evo.12641</a>.","short":"N.H. Barton, M. Servedio, Evolution 69 (2015) 1101–1112."},"_id":"1519","title":"The interpretation of selection coefficients","date_updated":"2025-09-23T13:53:01Z","day":"19","ec_funded":1,"status":"public","doi":"10.1111/evo.12641","quality_controlled":"1","scopus_import":"1","oa_version":"Submitted Version","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"1101 - 1112","ddc":["570"],"article_processing_charge":"No","type":"journal_article"},{"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","page":"580 - 607","status":"public","doi":"10.5281/zenodo.33178","quality_controlled":"1","article_processing_charge":"No","type":"journal_article","ddc":["020"],"title":"Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA","_id":"1525","OA_place":"publisher","file":[{"file_name":"IST-2016-720-v1+1_OANA_OA-Empfehlungen_12-11-2015.pdf","date_updated":"2020-07-14T12:45:00Z","file_id":"5317","checksum":"a495fe253bbc7615b1d60e9e85c94408","creator":"system","content_type":"application/pdf","file_size":931707,"relation":"main_file","date_created":"2018-12-12T10:17:59Z","access_level":"open_access"}],"publisher":"Verein Österreichischer Bibliothekare","department":[{"_id":"E-Lib"}],"has_accepted_license":"1","publication":"VÖB Mitteilungen","citation":{"ieee":"B. Bauer <i>et al.</i>, “Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA,” <i>VÖB Mitteilungen</i>, vol. 68, no. 3. Verein Österreichischer Bibliothekare, pp. 580–607, 2015.","apa":"Bauer, B., Blechl, G., Bock, C., Danowski, P., Ferus, A., Graschopf, A., … Welzig, E. (2015). Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA. <i>VÖB Mitteilungen</i>. Verein Österreichischer Bibliothekare. <a href=\"https://doi.org/10.5281/zenodo.33178\">https://doi.org/10.5281/zenodo.33178</a>","mla":"Bauer, Bruno, et al. “Arbeitsgruppe „Nationale Strategie“ Des Open Access Network Austria OANA.” <i>VÖB Mitteilungen</i>, vol. 68, no. 3, Verein Österreichischer Bibliothekare, 2015, pp. 580–607, doi:<a href=\"https://doi.org/10.5281/zenodo.33178\">10.5281/zenodo.33178</a>.","ama":"Bauer B, Blechl G, Bock C, et al. Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA. <i>VÖB Mitteilungen</i>. 2015;68(3):580-607. doi:<a href=\"https://doi.org/10.5281/zenodo.33178\">10.5281/zenodo.33178</a>","chicago":"Bauer, Bruno, Guido Blechl, Christoph Bock, Patrick Danowski, Andreas Ferus, Anton Graschopf, Thomas König, et al. “Arbeitsgruppe „Nationale Strategie“ Des Open Access Network Austria OANA.” <i>VÖB Mitteilungen</i>. Verein Österreichischer Bibliothekare, 2015. <a href=\"https://doi.org/10.5281/zenodo.33178\">https://doi.org/10.5281/zenodo.33178</a>.","ista":"Bauer B, Blechl G, Bock C, Danowski P, Ferus A, Graschopf A, König T, Mayer K, Reckling F, Rieck K, Seitz P, Stöger H, Welzig E. 2015. Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA. VÖB Mitteilungen. 68(3), 580–607.","short":"B. Bauer, G. Blechl, C. Bock, P. Danowski, A. Ferus, A. Graschopf, T. König, K. Mayer, F. Reckling, K. Rieck, P. Seitz, H. Stöger, E. Welzig, VÖB Mitteilungen 68 (2015) 580–607."},"day":"12","OA_type":"gold","date_updated":"2026-04-29T05:58:40Z","publication_status":"published","pubrep_id":"720","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"author":[{"first_name":"Bruno","last_name":"Bauer","full_name":"Bauer, Bruno"},{"full_name":"Blechl, Guido","last_name":"Blechl","first_name":"Guido"},{"last_name":"Bock","first_name":"Christoph","full_name":"Bock, Christoph"},{"orcid":"0000-0002-6026-4409","full_name":"Danowski, Patrick","id":"2EBD1598-F248-11E8-B48F-1D18A9856A87","first_name":"Patrick","last_name":"Danowski"},{"full_name":"Ferus, Andreas","first_name":"Andreas","last_name":"Ferus"},{"full_name":"Graschopf, Anton","first_name":"Anton","last_name":"Graschopf"},{"full_name":"König, Thomas","first_name":"Thomas","last_name":"König"},{"first_name":"Katja","last_name":"Mayer","full_name":"Mayer, Katja"},{"full_name":"Reckling, Falk","last_name":"Reckling","first_name":"Falk"},{"last_name":"Rieck","first_name":"Katharina","full_name":"Rieck, Katharina"},{"first_name":"Peter","last_name":"Seitz","full_name":"Seitz, Peter"},{"full_name":"Stöger, Herwig","first_name":"Herwig","last_name":"Stöger"},{"full_name":"Welzig, Elvira","last_name":"Welzig","first_name":"Elvira"}],"date_created":"2018-12-11T11:52:31Z","date_published":"2015-11-12T00:00:00Z","file_date_updated":"2020-07-14T12:45:00Z","year":"2015","publist_id":"5648","article_type":"original","intvolume":"        68","language":[{"iso":"eng"}],"oa":1,"issue":"3","month":"11","abstract":[{"text":"Based on 16 recommendations, efforts should be made to achieve the following goal: By 2025, all scholarly publication activity in Austria should be Open Access. In other words, the final versions of all scholarly publications resulting from the support of public resources must be freely accessible on the Internet without delay (Gold Open Access). The resources required to meet this obligation shall be provided to the authors, or the cost of the publication venues shall be borne directly by the research organisations.","lang":"eng"}],"volume":68},{"title":"Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism","_id":"1534","has_accepted_license":"1","publication":"Nature Communications","citation":{"ama":"Wang H, Yang K, Zou J, et al. Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism. <i>Nature Communications</i>. 2015;6. doi:<a href=\"https://doi.org/10.1038/ncomms9822\">10.1038/ncomms9822</a>","ieee":"H. Wang <i>et al.</i>, “Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism,” <i>Nature Communications</i>, vol. 6. Nature Publishing Group, 2015.","mla":"Wang, Hongzhe, et al. “Transcriptional Regulation of PIN Genes by FOUR LIPS and MYB88 during Arabidopsis Root Gravitropism.” <i>Nature Communications</i>, vol. 6, 8822, Nature Publishing Group, 2015, doi:<a href=\"https://doi.org/10.1038/ncomms9822\">10.1038/ncomms9822</a>.","apa":"Wang, H., Yang, K., Zou, J., Zhu, L., Xie, Z., Morita, M., … Le, J. (2015). Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncomms9822\">https://doi.org/10.1038/ncomms9822</a>","short":"H. Wang, K. Yang, J. Zou, L. Zhu, Z. Xie, M. Morita, M. Tasaka, J. Friml, E. Grotewold, T. Beeckman, S. Vanneste, F. Sack, J. Le, Nature Communications 6 (2015).","chicago":"Wang, Hongzhe, Kezhen Yang, Junjie Zou, Lingling Zhu, Zidian Xie, Miyoterao Morita, Masao Tasaka, et al. “Transcriptional Regulation of PIN Genes by FOUR LIPS and MYB88 during Arabidopsis Root Gravitropism.” <i>Nature Communications</i>. Nature Publishing Group, 2015. <a href=\"https://doi.org/10.1038/ncomms9822\">https://doi.org/10.1038/ncomms9822</a>.","ista":"Wang H, Yang K, Zou J, Zhu L, Xie Z, Morita M, Tasaka M, Friml J, Grotewold E, Beeckman T, Vanneste S, Sack F, Le J. 2015. Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism. Nature Communications. 6, 8822."},"file":[{"file_size":1852268,"content_type":"application/pdf","creator":"system","access_level":"open_access","date_created":"2018-12-12T10:17:07Z","relation":"main_file","date_updated":"2020-07-14T12:45:01Z","file_name":"IST-2016-485-v1+1_ncomms9822.pdf","checksum":"3c06735fc7cd7e482ca830cbd26001bf","file_id":"5259"}],"publisher":"Nature Publishing Group","department":[{"_id":"JiFr"}],"day":"18","date_updated":"2025-09-23T14:55:59Z","oa_version":"Published Version","scopus_import":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","doi":"10.1038/ncomms9822","quality_controlled":"1","status":"public","ec_funded":1,"type":"journal_article","article_processing_charge":"No","ddc":["570"],"date_published":"2015-11-18T00:00:00Z","file_date_updated":"2020-07-14T12:45:01Z","publist_id":"5637","year":"2015","date_created":"2018-12-11T11:52:34Z","isi":1,"oa":1,"language":[{"iso":"eng"}],"intvolume":"         6","abstract":[{"text":"PIN proteins are auxin export carriers that direct intercellular auxin flow and in turn regulate many aspects of plant growth and development including responses to environmental changes. The Arabidopsis R2R3-MYB transcription factor FOUR LIPS (FLP) and its paralogue MYB88 regulate terminal divisions during stomatal development, as well as female reproductive development and stress responses. Here we show that FLP and MYB88 act redundantly but differentially in regulating the transcription of PIN3 and PIN7 in gravity-sensing cells of primary and lateral roots. On the one hand, FLP is involved in responses to gravity stimulation in primary roots, whereas on the other, FLP and MYB88 function complementarily in establishing the gravitropic set-point angles of lateral roots. Our results support a model in which FLP and MYB88 expression specifically determines the temporal-spatial patterns of PIN3 and PIN7 transcription that are closely associated with their preferential functions during root responses to gravity.","lang":"eng"}],"month":"11","volume":6,"project":[{"_id":"25716A02-B435-11E9-9278-68D0E5697425","name":"Polarity and subcellular dynamics in plants","grant_number":"282300","call_identifier":"FP7"}],"external_id":{"isi":["000366295500008"]},"publication_status":"published","pubrep_id":"485","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_number":"8822","author":[{"first_name":"Hongzhe","last_name":"Wang","full_name":"Wang, Hongzhe"},{"full_name":"Yang, Kezhen","first_name":"Kezhen","last_name":"Yang"},{"last_name":"Zou","first_name":"Junjie","full_name":"Zou, Junjie"},{"full_name":"Zhu, Lingling","first_name":"Lingling","last_name":"Zhu"},{"full_name":"Xie, Zidian","last_name":"Xie","first_name":"Zidian"},{"first_name":"Miyoterao","last_name":"Morita","full_name":"Morita, Miyoterao"},{"first_name":"Masao","last_name":"Tasaka","full_name":"Tasaka, Masao"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","last_name":"Friml","first_name":"Jirí"},{"last_name":"Grotewold","first_name":"Erich","full_name":"Grotewold, Erich"},{"full_name":"Beeckman, Tom","last_name":"Beeckman","first_name":"Tom"},{"first_name":"Steffen","last_name":"Vanneste","full_name":"Vanneste, Steffen"},{"full_name":"Sack, Fred","last_name":"Sack","first_name":"Fred"},{"last_name":"Le","first_name":"Jie","full_name":"Le, Jie"}]},{"title":"Cav1.3 channels as key regulators of neuron-like firings and catecholamine release in chromaffin cells","_id":"1535","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384372/","open_access":"1"}],"publisher":"Bentham Science Publishers","department":[{"_id":"PeJo"}],"publication":"Current Molecular Pharmacology","citation":{"short":"D.H. Vandael, A. Marcantoni, E. Carbone, Current Molecular Pharmacology 8 (2015) 149–161.","chicago":"Vandael, David H, Andrea Marcantoni, and Emilio Carbone. “Cav1.3 Channels as Key Regulators of Neuron-like Firings and Catecholamine Release in Chromaffin Cells.” <i>Current Molecular Pharmacology</i>. Bentham Science Publishers, 2015. <a href=\"https://doi.org/10.2174/1874467208666150507105443\">https://doi.org/10.2174/1874467208666150507105443</a>.","ista":"Vandael DH, Marcantoni A, Carbone E. 2015. Cav1.3 channels as key regulators of neuron-like firings and catecholamine release in chromaffin cells. Current Molecular Pharmacology. 8(2), 149–161.","ama":"Vandael DH, Marcantoni A, Carbone E. Cav1.3 channels as key regulators of neuron-like firings and catecholamine release in chromaffin cells. <i>Current Molecular Pharmacology</i>. 2015;8(2):149-161. doi:<a href=\"https://doi.org/10.2174/1874467208666150507105443\">10.2174/1874467208666150507105443</a>","ieee":"D. H. Vandael, A. Marcantoni, and E. Carbone, “Cav1.3 channels as key regulators of neuron-like firings and catecholamine release in chromaffin cells,” <i>Current Molecular Pharmacology</i>, vol. 8, no. 2. Bentham Science Publishers, pp. 149–161, 2015.","apa":"Vandael, D. H., Marcantoni, A., &#38; Carbone, E. (2015). Cav1.3 channels as key regulators of neuron-like firings and catecholamine release in chromaffin cells. <i>Current Molecular Pharmacology</i>. Bentham Science Publishers. <a href=\"https://doi.org/10.2174/1874467208666150507105443\">https://doi.org/10.2174/1874467208666150507105443</a>","mla":"Vandael, David H., et al. “Cav1.3 Channels as Key Regulators of Neuron-like Firings and Catecholamine Release in Chromaffin Cells.” <i>Current Molecular Pharmacology</i>, vol. 8, no. 2, Bentham Science Publishers, 2015, pp. 149–61, doi:<a href=\"https://doi.org/10.2174/1874467208666150507105443\">10.2174/1874467208666150507105443</a>."},"day":"01","date_updated":"2025-09-23T08:12:18Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa_version":"Submitted Version","scopus_import":"1","page":"149 - 161","status":"public","doi":"10.2174/1874467208666150507105443","quality_controlled":"1","article_processing_charge":"No","type":"journal_article","date_created":"2018-12-11T11:52:35Z","date_published":"2015-10-01T00:00:00Z","publist_id":"5636","article_type":"original","year":"2015","intvolume":"         8","acknowledgement":"This work was supported by the Italian MIUR (PRIN 2010/2011 project 2010JFYFY2) and the University of Torino.","language":[{"iso":"eng"}],"oa":1,"isi":1,"issue":"2","month":"10","abstract":[{"lang":"eng","text":"Neuronal and neuroendocrine L-type calcium channels (Cav1.2, Cav1.3) open readily at relatively low membrane potentials and allow Ca2+ to enter the cells near resting potentials. In this way, Cav1.2 and Cav1.3 shape the action potential waveform, contribute to gene expression, synaptic plasticity, neuronal differentiation, hormone secretion and pacemaker activity. In the chromaffin cells (CCs) of the adrenal medulla, Cav1.3 is highly expressed and is shown to support most of the pacemaking current that sustains action potential (AP) firings and part of the catecholamine secretion. Cav1.3 forms Ca2+-nanodomains with the fast inactivating BK channels and drives the resting SK currents. These latter set the inter-spike interval duration between consecutive spikes during spontaneous firing and the rate of spike adaptation during sustained depolarizations. Cav1.3 plays also a primary role in the switch from “tonic” to “burst” firing that occurs in mouse CCs when either the availability of voltage-gated Na channels (Nav) is reduced or the β2 subunit featuring the fast inactivating BK channels is deleted. Here, we discuss the functional role of these “neuronlike” firing modes in CCs and how Cav1.3 contributes to them. The open issue is to understand how these novel firing patterns are adapted to regulate the quantity of circulating catecholamines during resting condition or in response to acute and chronic stress."}],"volume":8,"publication_status":"published","pmid":1,"external_id":{"isi":["000217186100005"],"pmid":["25966692"]},"author":[{"first_name":"David H","last_name":"Vandael","orcid":"0000-0001-7577-1676","full_name":"Vandael, David H","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Marcantoni","first_name":"Andrea","full_name":"Marcantoni, Andrea"},{"first_name":"Emilio","last_name":"Carbone","full_name":"Carbone, Emilio"}]},{"article_processing_charge":"No","type":"journal_article","ddc":["570"],"related_material":{"record":[{"relation":"dissertation_contains","id":"961","status":"public"}]},"page":"673 - 685","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa_version":"Published Version","scopus_import":"1","status":"public","quality_controlled":"1","doi":"10.1016/j.cell.2015.01.008","day":"12","date_updated":"2026-04-08T14:22:39Z","title":"Cortical contractility triggers a stochastic switch to fast amoeboid cell motility","_id":"1537","department":[{"_id":"CaHe"},{"_id":"MiSi"}],"publisher":"Cell Press","file":[{"file_name":"IST-2016-484-v1+1_1-s2.0-S0092867415000094-main.pdf","date_updated":"2020-07-14T12:45:01Z","checksum":"228d3edf40627d897b3875088a0ac51f","file_id":"5003","creator":"system","file_size":4362653,"content_type":"application/pdf","relation":"main_file","date_created":"2018-12-12T10:13:21Z","access_level":"open_access"}],"citation":{"ista":"Ruprecht V, Wieser S, Callan Jones A, Smutny M, Morita H, Sako K, Barone V, Ritsch Marte M, Sixt MK, Voituriez R, Heisenberg C-PJ. 2015. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. Cell. 160(4), 673–685.","chicago":"Ruprecht, Verena, Stefan Wieser, Andrew Callan Jones, Michael Smutny, Hitoshi Morita, Keisuke Sako, Vanessa Barone, et al. “Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility.” <i>Cell</i>. Cell Press, 2015. <a href=\"https://doi.org/10.1016/j.cell.2015.01.008\">https://doi.org/10.1016/j.cell.2015.01.008</a>.","short":"V. Ruprecht, S. Wieser, A. Callan Jones, M. Smutny, H. Morita, K. Sako, V. Barone, M. Ritsch Marte, M.K. Sixt, R. Voituriez, C.-P.J. Heisenberg, Cell 160 (2015) 673–685.","apa":"Ruprecht, V., Wieser, S., Callan Jones, A., Smutny, M., Morita, H., Sako, K., … Heisenberg, C.-P. J. (2015). Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. <i>Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cell.2015.01.008\">https://doi.org/10.1016/j.cell.2015.01.008</a>","mla":"Ruprecht, Verena, et al. “Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility.” <i>Cell</i>, vol. 160, no. 4, Cell Press, 2015, pp. 673–85, doi:<a href=\"https://doi.org/10.1016/j.cell.2015.01.008\">10.1016/j.cell.2015.01.008</a>.","ieee":"V. Ruprecht <i>et al.</i>, “Cortical contractility triggers a stochastic switch to fast amoeboid cell motility,” <i>Cell</i>, vol. 160, no. 4. Cell Press, pp. 673–685, 2015.","ama":"Ruprecht V, Wieser S, Callan Jones A, et al. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. <i>Cell</i>. 2015;160(4):673-685. doi:<a href=\"https://doi.org/10.1016/j.cell.2015.01.008\">10.1016/j.cell.2015.01.008</a>"},"publication":"Cell","has_accepted_license":"1","pubrep_id":"484","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"published","corr_author":"1","external_id":{"isi":["000349208800011"]},"author":[{"first_name":"Verena","last_name":"Ruprecht","orcid":"0000-0003-4088-8633","full_name":"Ruprecht, Verena","id":"4D71A03A-F248-11E8-B48F-1D18A9856A87"},{"id":"355AA5A0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2670-2217","full_name":"Wieser, Stefan","last_name":"Wieser","first_name":"Stefan"},{"full_name":"Callan Jones, Andrew","first_name":"Andrew","last_name":"Callan Jones"},{"orcid":"0000-0002-5920-9090","full_name":"Smutny, Michael","id":"3FE6E4E8-F248-11E8-B48F-1D18A9856A87","first_name":"Michael","last_name":"Smutny"},{"last_name":"Morita","first_name":"Hitoshi","id":"4C6E54C6-F248-11E8-B48F-1D18A9856A87","full_name":"Morita, Hitoshi"},{"id":"3BED66BE-F248-11E8-B48F-1D18A9856A87","full_name":"Sako, Keisuke","orcid":"0000-0002-6453-8075","last_name":"Sako","first_name":"Keisuke"},{"first_name":"Vanessa","last_name":"Barone","full_name":"Barone, Vanessa","orcid":"0000-0003-2676-3367","id":"419EECCC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Ritsch Marte, Monika","first_name":"Monika","last_name":"Ritsch Marte"},{"last_name":"Sixt","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K"},{"first_name":"Raphaël","last_name":"Voituriez","full_name":"Voituriez, Raphaël"},{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","last_name":"Heisenberg"}],"project":[{"_id":"2529486C-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"T 560-B17","name":"Cell- and Tissue Mechanics in Zebrafish Germ Layer Formation"},{"_id":"2527D5CC-B435-11E9-9278-68D0E5697425","name":"Cell Cortex and Germ Layer Formation in Zebrafish Gastrulation","call_identifier":"FWF","grant_number":"I812-B12"}],"acknowledged_ssus":[{"_id":"SSU"}],"month":"02","abstract":[{"text":"3D amoeboid cell migration is central to many developmental and disease-related processes such as cancer metastasis. Here, we identify a unique prototypic amoeboid cell migration mode in early zebrafish embryos, termed stable-bleb migration. Stable-bleb cells display an invariant polarized balloon-like shape with exceptional migration speed and persistence. Progenitor cells can be reversibly transformed into stable-bleb cells irrespective of their primary fate and motile characteristics by increasing myosin II activity through biochemical or mechanical stimuli. Using a combination of theory and experiments, we show that, in stable-bleb cells, cortical contractility fluctuations trigger a stochastic switch into amoeboid motility, and a positive feedback between cortical flows and gradients in contractility maintains stable-bleb cell polarization. We further show that rearward cortical flows drive stable-bleb cell migration in various adhesive and non-adhesive environments, unraveling a highly versatile amoeboid migration phenotype.","lang":"eng"}],"volume":160,"date_created":"2018-12-11T11:52:35Z","publist_id":"5634","year":"2015","file_date_updated":"2020-07-14T12:45:01Z","date_published":"2015-02-12T00:00:00Z","intvolume":"       160","language":[{"iso":"eng"}],"acknowledgement":"We would like to thank R. Hausschild and E. Papusheva for technical assistance and the service facilities at the IST Austria for continuous support. The caRhoA plasmid was a kind gift of T. Kudoh and A. Takesono. We thank M. Piel and E. Paluch for exchanging unpublished data. ","issue":"4","oa":1,"isi":1}]