---
_id: '9678'
abstract:
- lang: eng
text: We introduce a new graph problem, the token dropping game, and we show how
to solve it efficiently in a distributed setting. We use the token dropping game
as a tool to design an efficient distributed algorithm for stable orientations
and more generally for locally optimal semi-matchings. The prior work by Czygrinow
et al. (DISC 2012) finds a stable orientation in O(Δ^5) rounds in graphs of maximum
degree Δ, while we improve it to O(Δ^4) and also prove a lower bound of Ω(Δ).
For the more general problem of locally optimal semi-matchings, the prior upper
bound is O(S^5) and our new algorithm runs in O(C · S^4) rounds, which is an improvement
for C = o(S); here C and S are the maximum degrees of customers and servers, respectively.
acknowledgement: We thank Orr Fischer, Juho Hirvonen, and Tuomo Lempiäinen for valuable
discussions. This project has received funding from the European Union’s Horizon
2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement
No. 840605.
article_processing_charge: No
author:
- first_name: Sebastian
full_name: Brandt, Sebastian
last_name: Brandt
- first_name: Barbara
full_name: Keller, Barbara
last_name: Keller
- first_name: Joel
full_name: Rybicki, Joel
id: 334EFD2E-F248-11E8-B48F-1D18A9856A87
last_name: Rybicki
orcid: 0000-0002-6432-6646
- first_name: Jukka
full_name: Suomela, Jukka
last_name: Suomela
- first_name: Jara
full_name: Uitto, Jara
last_name: Uitto
citation:
ama: 'Brandt S, Keller B, Rybicki J, Suomela J, Uitto J. Efficient load-balancing
through distributed token dropping. In: Annual ACM Symposium on Parallelism
in Algorithms and Architectures. ; 2021:129-139. doi:10.1145/3409964.3461785'
apa: Brandt, S., Keller, B., Rybicki, J., Suomela, J., & Uitto, J. (2021). Efficient
load-balancing through distributed token dropping. In Annual ACM Symposium
on Parallelism in Algorithms and Architectures (pp. 129–139). Virtual Event,
United States. https://doi.org/10.1145/3409964.3461785
chicago: Brandt, Sebastian, Barbara Keller, Joel Rybicki, Jukka Suomela, and Jara
Uitto. “Efficient Load-Balancing through Distributed Token Dropping.” In Annual
ACM Symposium on Parallelism in Algorithms and Architectures, 129–39, 2021.
https://doi.org/10.1145/3409964.3461785.
ieee: S. Brandt, B. Keller, J. Rybicki, J. Suomela, and J. Uitto, “Efficient load-balancing
through distributed token dropping,” in Annual ACM Symposium on Parallelism
in Algorithms and Architectures, Virtual Event, United States, 2021, pp.
129–139.
ista: 'Brandt S, Keller B, Rybicki J, Suomela J, Uitto J. 2021. Efficient load-balancing
through distributed token dropping. Annual ACM Symposium on Parallelism in Algorithms
and Architectures. SPAA: Symposium on Parallelism in Algorithms and Architectures
, 129–139.'
mla: Brandt, Sebastian, et al. “Efficient Load-Balancing through Distributed Token
Dropping.” Annual ACM Symposium on Parallelism in Algorithms and Architectures,
2021, pp. 129–39, doi:10.1145/3409964.3461785.
short: S. Brandt, B. Keller, J. Rybicki, J. Suomela, J. Uitto, in:, Annual ACM Symposium
on Parallelism in Algorithms and Architectures, 2021, pp. 129–139.
conference:
end_date: 2021-07-08
location: ' Virtual Event, United States'
name: 'SPAA: Symposium on Parallelism in Algorithms and Architectures '
start_date: 2021-07-06
date_created: 2021-07-18T22:01:22Z
date_published: 2021-07-06T00:00:00Z
date_updated: 2024-03-05T07:13:12Z
day: '06'
department:
- _id: DaAl
doi: 10.1145/3409964.3461785
ec_funded: 1
external_id:
arxiv:
- '2005.07761'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2005.07761
month: '07'
oa: 1
oa_version: Preprint
page: 129-139
project:
- _id: 26A5D39A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '840605'
name: Coordination in constrained and natural distributed systems
publication: Annual ACM Symposium on Parallelism in Algorithms and Architectures
publication_identifier:
isbn:
- '9781450380706'
publication_status: published
quality_controlled: '1'
related_material:
record:
- id: '15074'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Efficient load-balancing through distributed token dropping
type: conference
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
year: '2021'
...
---
_id: '8286'
abstract:
- lang: eng
text: "We consider the following dynamic load-balancing process: given an underlying
graph G with n nodes, in each step t≥ 0, one unit of load is created, and placed
at a randomly chosen graph node. In the same step, the chosen node picks a random
neighbor, and the two nodes balance their loads by averaging them. We are interested
in the expected gap between the minimum and maximum loads at nodes as the process
progresses, and its dependence on n and on the graph structure. Variants of the
above graphical balanced allocation process have been studied previously by Peres,
Talwar, and Wieder [Peres et al., 2015], and by Sauerwald and Sun [Sauerwald and
Sun, 2015]. These authors left as open the question of characterizing the gap
in the case of cycle graphs in the dynamic case, where weights are created during
the algorithm’s execution. For this case, the only known upper bound is of \U0001D4AA(n
log n), following from a majorization argument due to [Peres et al., 2015], which
analyzes a related graphical allocation process. In this paper, we provide an
upper bound of \U0001D4AA (√n log n) on the expected gap of the above process
for cycles of length n. We introduce a new potential analysis technique, which
enables us to bound the difference in load between k-hop neighbors on the cycle,
for any k ≤ n/2. We complement this with a \"gap covering\" argument, which bounds
the maximum value of the gap by bounding its value across all possible subsets
of a certain structure, and recursively bounding the gaps within each subset.
We provide analytical and experimental evidence that our upper bound on the gap
is tight up to a logarithmic factor. "
acknowledgement: The authors sincerely thank Thomas Sauerwald and George Giakkoupis
for insightful discussions, and Mohsen Ghaffari, Yuval Peres, and Udi Wieder for
feedback on earlier versions of this draft. We also thank the ICALP anonymous reviewers
for their very useful comments. Open access funding provided by Institute of Science
and Technology (IST Austria). Funding was provided by European Research Council
(Grant No. PR1042ERC01).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: Giorgi
full_name: Nadiradze, Giorgi
id: 3279A00C-F248-11E8-B48F-1D18A9856A87
last_name: Nadiradze
orcid: 0000-0001-5634-0731
- first_name: Amirmojtaba
full_name: Sabour, Amirmojtaba
id: bcc145fd-e77f-11ea-ae8b-80d661dbff67
last_name: Sabour
citation:
ama: Alistarh D-A, Nadiradze G, Sabour A. Dynamic averaging load balancing on cycles.
Algorithmica. 2021. doi:10.1007/s00453-021-00905-9
apa: 'Alistarh, D.-A., Nadiradze, G., & Sabour, A. (2021). Dynamic averaging
load balancing on cycles. Algorithmica. Virtual, Online; Germany: Springer
Nature. https://doi.org/10.1007/s00453-021-00905-9'
chicago: Alistarh, Dan-Adrian, Giorgi Nadiradze, and Amirmojtaba Sabour. “Dynamic
Averaging Load Balancing on Cycles.” Algorithmica. Springer Nature, 2021.
https://doi.org/10.1007/s00453-021-00905-9.
ieee: D.-A. Alistarh, G. Nadiradze, and A. Sabour, “Dynamic averaging load balancing
on cycles,” Algorithmica. Springer Nature, 2021.
ista: Alistarh D-A, Nadiradze G, Sabour A. 2021. Dynamic averaging load balancing
on cycles. Algorithmica.
mla: Alistarh, Dan-Adrian, et al. “Dynamic Averaging Load Balancing on Cycles.”
Algorithmica, Springer Nature, 2021, doi:10.1007/s00453-021-00905-9.
short: D.-A. Alistarh, G. Nadiradze, A. Sabour, Algorithmica (2021).
conference:
end_date: 2020-07-11
location: Virtual, Online; Germany
name: 'ICALP: International Colloquium on Automata, Languages, and Programming '
start_date: 2020-07-08
date_created: 2020-08-24T06:24:04Z
date_published: 2021-12-24T00:00:00Z
date_updated: 2024-03-05T07:35:53Z
day: '24'
ddc:
- '000'
department:
- _id: DaAl
doi: 10.1007/s00453-021-00905-9
ec_funded: 1
external_id:
arxiv:
- '2003.09297'
isi:
- '000734004600001'
file:
- access_level: open_access
checksum: 21169b25b0c8e17b21e12af22bff9870
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-27T10:36:40Z
date_updated: 2021-12-27T10:36:40Z
file_id: '10577'
file_name: 2021_Algorithmica_Alistarh.pdf
file_size: 525950
relation: main_file
success: 1
file_date_updated: 2021-12-27T10:36:40Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Algorithmica
publication_identifier:
eissn:
- 1432-0541
issn:
- 0178-4617
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://doi.org/10.4230/LIPIcs.ICALP.2020.7
record:
- id: '15077'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Dynamic averaging load balancing on cycles
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2021'
...
---
_id: '9733'
abstract:
- lang: eng
text: This thesis is the result of the research carried out by the author during
his PhD at IST Austria between 2017 and 2021. It mainly focuses on the Fröhlich
polaron model, specifically to its regime of strong coupling. This model, which
is rigorously introduced and discussed in the introduction, has been of great
interest in condensed matter physics and field theory for more than eighty years.
It is used to describe an electron interacting with the atoms of a solid material
(the strength of this interaction is modeled by the presence of a coupling constant
α in the Hamiltonian of the system). The particular regime examined here, which
is mathematically described by considering the limit α →∞, displays many interesting
features related to the emergence of classical behavior, which allows for a simplified
effective description of the system under analysis. The properties, the range
of validity and a quantitative analysis of the precision of such classical approximations
are the main object of the present work. We specify our investigation to the study
of the ground state energy of the system, its dynamics and its effective mass.
For each of these problems, we provide in the introduction an overview of the
previously known results and a detailed account of the original contributions
by the author.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Dario
full_name: Feliciangeli, Dario
id: 41A639AA-F248-11E8-B48F-1D18A9856A87
last_name: Feliciangeli
orcid: 0000-0003-0754-8530
citation:
ama: Feliciangeli D. The polaron at strong coupling. 2021. doi:10.15479/at:ista:9733
apa: Feliciangeli, D. (2021). The polaron at strong coupling. Institute of
Science and Technology Austria. https://doi.org/10.15479/at:ista:9733
chicago: Feliciangeli, Dario. “The Polaron at Strong Coupling.” Institute of Science
and Technology Austria, 2021. https://doi.org/10.15479/at:ista:9733.
ieee: D. Feliciangeli, “The polaron at strong coupling,” Institute of Science and
Technology Austria, 2021.
ista: Feliciangeli D. 2021. The polaron at strong coupling. Institute of Science
and Technology Austria.
mla: Feliciangeli, Dario. The Polaron at Strong Coupling. Institute of Science
and Technology Austria, 2021, doi:10.15479/at:ista:9733.
short: D. Feliciangeli, The Polaron at Strong Coupling, Institute of Science and
Technology Austria, 2021.
date_created: 2021-07-27T15:48:30Z
date_published: 2021-08-20T00:00:00Z
date_updated: 2024-03-06T12:30:44Z
day: '20'
ddc:
- '515'
- '519'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RoSe
- _id: JaMa
doi: 10.15479/at:ista:9733
ec_funded: 1
file:
- access_level: open_access
checksum: e88bb8ca43948abe060eb2d2fa719881
content_type: application/pdf
creator: dfelicia
date_created: 2021-08-19T14:03:48Z
date_updated: 2021-09-06T09:28:56Z
file_id: '9944'
file_name: Thesis_FeliciangeliA.pdf
file_size: 1958710
relation: main_file
- access_level: closed
checksum: 72810843abee83705853505b3f8348aa
content_type: application/octet-stream
creator: dfelicia
date_created: 2021-08-19T14:06:35Z
date_updated: 2022-03-10T12:13:57Z
file_id: '9945'
file_name: thesis.7z
file_size: 3771669
relation: source_file
file_date_updated: 2022-03-10T12:13:57Z
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nd/4.0/
month: '08'
oa: 1
oa_version: Published Version
page: '180'
project:
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '716117'
name: Optimal Transport and Stochastic Dynamics
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
grant_number: F6504
name: Taming Complexity in Partial Differential Systems
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9787'
relation: part_of_dissertation
status: public
- id: '9792'
relation: part_of_dissertation
status: public
- id: '9225'
relation: part_of_dissertation
status: public
- id: '9781'
relation: part_of_dissertation
status: public
- id: '9791'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Jan
full_name: Maas, Jan
id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
last_name: Maas
orcid: 0000-0002-0845-1338
title: The polaron at strong coupling
tmp:
image: /image/cc_by_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nd/4.0/legalcode
name: Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
short: CC BY-ND (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '9571'
abstract:
- lang: eng
text: As the size and complexity of models and datasets grow, so does the need for
communication-efficient variants of stochastic gradient descent that can be deployed
to perform parallel model training. One popular communication-compression method
for data-parallel SGD is QSGD (Alistarh et al., 2017), which quantizes and encodes
gradients to reduce communication costs. The baseline variant of QSGD provides
strong theoretical guarantees, however, for practical purposes, the authors proposed
a heuristic variant which we call QSGDinf, which demonstrated impressive empirical
gains for distributed training of large neural networks. In this paper, we build
on this work to propose a new gradient quantization scheme, and show that it has
both stronger theoretical guarantees than QSGD, and matches and exceeds the empirical
performance of the QSGDinf heuristic and of other compression methods.
article_processing_charge: No
article_type: original
author:
- first_name: Ali
full_name: Ramezani-Kebrya, Ali
last_name: Ramezani-Kebrya
- first_name: Fartash
full_name: Faghri, Fartash
last_name: Faghri
- first_name: Ilya
full_name: Markov, Ilya
last_name: Markov
- first_name: Vitalii
full_name: Aksenov, Vitalii
id: 2980135A-F248-11E8-B48F-1D18A9856A87
last_name: Aksenov
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: Daniel M.
full_name: Roy, Daniel M.
last_name: Roy
citation:
ama: 'Ramezani-Kebrya A, Faghri F, Markov I, Aksenov V, Alistarh D-A, Roy DM. NUQSGD:
Provably communication-efficient data-parallel SGD via nonuniform quantization.
Journal of Machine Learning Research. 2021;22(114):1−43.'
apa: 'Ramezani-Kebrya, A., Faghri, F., Markov, I., Aksenov, V., Alistarh, D.-A.,
& Roy, D. M. (2021). NUQSGD: Provably communication-efficient data-parallel
SGD via nonuniform quantization. Journal of Machine Learning Research.
Journal of Machine Learning Research.'
chicago: 'Ramezani-Kebrya, Ali, Fartash Faghri, Ilya Markov, Vitalii Aksenov, Dan-Adrian
Alistarh, and Daniel M. Roy. “NUQSGD: Provably Communication-Efficient Data-Parallel
SGD via Nonuniform Quantization.” Journal of Machine Learning Research.
Journal of Machine Learning Research, 2021.'
ieee: 'A. Ramezani-Kebrya, F. Faghri, I. Markov, V. Aksenov, D.-A. Alistarh, and
D. M. Roy, “NUQSGD: Provably communication-efficient data-parallel SGD via nonuniform
quantization,” Journal of Machine Learning Research, vol. 22, no. 114.
Journal of Machine Learning Research, p. 1−43, 2021.'
ista: 'Ramezani-Kebrya A, Faghri F, Markov I, Aksenov V, Alistarh D-A, Roy DM. 2021.
NUQSGD: Provably communication-efficient data-parallel SGD via nonuniform quantization.
Journal of Machine Learning Research. 22(114), 1−43.'
mla: 'Ramezani-Kebrya, Ali, et al. “NUQSGD: Provably Communication-Efficient Data-Parallel
SGD via Nonuniform Quantization.” Journal of Machine Learning Research,
vol. 22, no. 114, Journal of Machine Learning Research, 2021, p. 1−43.'
short: A. Ramezani-Kebrya, F. Faghri, I. Markov, V. Aksenov, D.-A. Alistarh, D.M.
Roy, Journal of Machine Learning Research 22 (2021) 1−43.
date_created: 2021-06-20T22:01:33Z
date_published: 2021-04-01T00:00:00Z
date_updated: 2024-03-06T12:22:07Z
day: '01'
ddc:
- '000'
department:
- _id: DaAl
external_id:
arxiv:
- '1908.06077'
file:
- access_level: open_access
checksum: 6428aa8bcb67768b6949c99b55d5281d
content_type: application/pdf
creator: asandaue
date_created: 2021-06-23T07:09:41Z
date_updated: 2021-06-23T07:09:41Z
file_id: '9595'
file_name: 2021_JournalOfMachineLearningResearch_Ramezani-Kebrya.pdf
file_size: 11237154
relation: main_file
success: 1
file_date_updated: 2021-06-23T07:09:41Z
has_accepted_license: '1'
intvolume: ' 22'
issue: '114'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.jmlr.org/papers/v22/20-255.html
month: '04'
oa: 1
oa_version: Published Version
page: 1−43
publication: Journal of Machine Learning Research
publication_identifier:
eissn:
- '15337928'
issn:
- '15324435'
publication_status: published
publisher: Journal of Machine Learning Research
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'NUQSGD: Provably communication-efficient data-parallel SGD via nonuniform
quantization'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2021'
...
---
_id: '8544'
abstract:
- lang: eng
text: The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic
branches, yet this hypothesis has not been causally tested in vivo in the mammalian
brain. Presynaptic ligand cerebellin-1 (Cbln1) and postsynaptic receptor GluD2
mediate synaptogenesis between granule cells and Purkinje cells in the molecular
layer of the cerebellar cortex. Here we show that sparse but not global knockout
of GluD2 causes under-elaboration of Purkinje cell dendrites in the deep molecular
layer and overelaboration in the superficial molecular layer. Developmental, overexpression,
structure-function, and genetic epistasis analyses indicate that dendrite morphogenesis
defects result from competitive synaptogenesis in a Cbln1/GluD2-dependent manner.
A generative model of dendritic growth based on competitive synaptogenesis largely
recapitulates GluD2 sparse and global knockout phenotypes. Our results support
the synaptotrophic hypothesis at initial stages of dendrite development, suggest
a second mode in which cumulative synapse formation inhibits further dendrite
growth, and highlight the importance of competition in dendrite morphogenesis.
acknowledgement: We thank M. Mishina for GluD2fl frozen embryos, T.C. Südhof and J.I.
Morgan for Cbln1fl mice, L. Anderson for help in generating the MADM alleles, W.
Joo for a previously unpublished construct, M. Yuzaki, K. Shen, J. Ding, and members
of the Luo lab, including J.M. Kebschull, H. Li, J. Li, T. Li, C.M. McLaughlin,
D. Pederick, J. Ren, D.C. Wang and C. Xu for discussions and critiques of the manuscript,
and M. Yuzaki for supporting Y.H.T. during the final phase of this project. Y.H.T.
was supported by a JSPS fellowship; S.A.S. was supported by a Stanford Graduate
Fellowship and an NSF Predoctoral Fellowship; L.J. is supported by a Stanford Graduate
Fellowship and an NSF Predoctoral Fellowship; M.J.W. is supported by a Burroughs
Wellcome Fund CASI Award. This work was supported by an NIH grant (R01-NS050538)
to L.L.; the European Research Council (ERC) under the European Union's Horizon
2020 research and innovations programme (No. 725780 LinPro) to S.H.; and Simons
and James S. McDonnell Foundations and an NSF CAREER award to S.G.; L.L. is an HHMI
investigator.
article_processing_charge: No
article_type: original
author:
- first_name: Yukari H.
full_name: Takeo, Yukari H.
last_name: Takeo
- first_name: S. Andrew
full_name: Shuster, S. Andrew
last_name: Shuster
- first_name: Linnie
full_name: Jiang, Linnie
last_name: Jiang
- first_name: Miley
full_name: Hu, Miley
last_name: Hu
- first_name: David J.
full_name: Luginbuhl, David J.
last_name: Luginbuhl
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Mark J.
full_name: Wagner, Mark J.
last_name: Wagner
- first_name: Surya
full_name: Ganguli, Surya
last_name: Ganguli
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
citation:
ama: Takeo YH, Shuster SA, Jiang L, et al. GluD2- and Cbln1-mediated competitive
synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. Neuron.
2021;109(4):P629-644.E8. doi:10.1016/j.neuron.2020.11.028
apa: Takeo, Y. H., Shuster, S. A., Jiang, L., Hu, M., Luginbuhl, D. J., Rülicke,
T., … Luo, L. (2021). GluD2- and Cbln1-mediated competitive synaptogenesis shapes
the dendritic arbors of cerebellar Purkinje cells. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.11.028
chicago: Takeo, Yukari H., S. Andrew Shuster, Linnie Jiang, Miley Hu, David J. Luginbuhl,
Thomas Rülicke, Ximena Contreras, et al. “GluD2- and Cbln1-Mediated Competitive
Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” Neuron.
Elsevier, 2021. https://doi.org/10.1016/j.neuron.2020.11.028.
ieee: Y. H. Takeo et al., “GluD2- and Cbln1-mediated competitive synaptogenesis
shapes the dendritic arbors of cerebellar Purkinje cells,” Neuron, vol.
109, no. 4. Elsevier, p. P629–644.E8, 2021.
ista: Takeo YH, Shuster SA, Jiang L, Hu M, Luginbuhl DJ, Rülicke T, Contreras X,
Hippenmeyer S, Wagner MJ, Ganguli S, Luo L. 2021. GluD2- and Cbln1-mediated competitive
synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. Neuron.
109(4), P629–644.E8.
mla: Takeo, Yukari H., et al. “GluD2- and Cbln1-Mediated Competitive Synaptogenesis
Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” Neuron, vol.
109, no. 4, Elsevier, 2021, p. P629–644.E8, doi:10.1016/j.neuron.2020.11.028.
short: Y.H. Takeo, S.A. Shuster, L. Jiang, M. Hu, D.J. Luginbuhl, T. Rülicke, X.
Contreras, S. Hippenmeyer, M.J. Wagner, S. Ganguli, L. Luo, Neuron 109 (2021)
P629–644.E8.
date_created: 2020-09-21T11:59:47Z
date_published: 2021-02-17T00:00:00Z
date_updated: 2024-03-06T12:12:48Z
day: '17'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2020.11.028
ec_funded: 1
intvolume: ' 109'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.06.14.151258
month: '02'
oa: 1
oa_version: Preprint
page: P629-644.E8
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors
of cerebellar Purkinje cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 109
year: '2021'
...
---
_id: '9791'
abstract:
- lang: eng
text: We provide a definition of the effective mass for the classical polaron described
by the Landau-Pekar equations. It is based on a novel variational principle, minimizing
the energy functional over states with given (initial) velocity. The resulting
formula for the polaron's effective mass agrees with the prediction by Landau
and Pekar.
acknowledgement: We thank Herbert Spohn for helpful comments. Funding from the European
Union’s Horizon 2020 research and innovation programme under the ERC grant agreement
No. 694227 (D.F. and R.S.) and under the Marie Skłodowska-Curie Grant Agreement
No. 754411 (S.R.) is gratefully acknowledged..
article_number: '2107.03720 '
article_processing_charge: No
author:
- first_name: Dario
full_name: Feliciangeli, Dario
id: 41A639AA-F248-11E8-B48F-1D18A9856A87
last_name: Feliciangeli
orcid: 0000-0003-0754-8530
- first_name: Simone Anna Elvira
full_name: Rademacher, Simone Anna Elvira
id: 856966FE-A408-11E9-977E-802DE6697425
last_name: Rademacher
orcid: 0000-0001-5059-4466
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Feliciangeli D, Rademacher SAE, Seiringer R. The effective mass problem for
the Landau-Pekar equations. arXiv.
apa: Feliciangeli, D., Rademacher, S. A. E., & Seiringer, R. (n.d.). The effective
mass problem for the Landau-Pekar equations. arXiv.
chicago: Feliciangeli, Dario, Simone Anna Elvira Rademacher, and Robert Seiringer.
“The Effective Mass Problem for the Landau-Pekar Equations.” ArXiv, n.d.
ieee: D. Feliciangeli, S. A. E. Rademacher, and R. Seiringer, “The effective mass
problem for the Landau-Pekar equations,” arXiv. .
ista: Feliciangeli D, Rademacher SAE, Seiringer R. The effective mass problem for
the Landau-Pekar equations. arXiv, 2107.03720.
mla: Feliciangeli, Dario, et al. “The Effective Mass Problem for the Landau-Pekar
Equations.” ArXiv, 2107.03720.
short: D. Feliciangeli, S.A.E. Rademacher, R. Seiringer, ArXiv (n.d.).
date_created: 2021-08-06T08:49:45Z
date_published: 2021-07-08T00:00:00Z
date_updated: 2024-03-06T12:30:45Z
day: '08'
ddc:
- '510'
department:
- _id: RoSe
ec_funded: 1
external_id:
arxiv:
- '2107.03720'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2107.03720
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
publication: arXiv
publication_status: submitted
related_material:
record:
- id: '10755'
relation: later_version
status: public
- id: '9733'
relation: dissertation_contains
status: public
status: public
title: The effective mass problem for the Landau-Pekar equations
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '7553'
abstract:
- lang: eng
text: Normative theories and statistical inference provide complementary approaches
for the study of biological systems. A normative theory postulates that organisms
have adapted to efficiently solve essential tasks, and proceeds to mathematically
work out testable consequences of such optimality; parameters that maximize the
hypothesized organismal function can be derived ab initio, without reference to
experimental data. In contrast, statistical inference focuses on efficient utilization
of data to learn model parameters, without reference to any a priori notion of
biological function, utility, or fitness. Traditionally, these two approaches
were developed independently and applied separately. Here we unify them in a coherent
Bayesian framework that embeds a normative theory into a family of maximum-entropy
“optimization priors.” This family defines a smooth interpolation between a data-rich
inference regime (characteristic of “bottom-up” statistical models), and a data-limited
ab inito prediction regime (characteristic of “top-down” normative theory). We
demonstrate the applicability of our framework using data from the visual cortex,
and argue that the flexibility it affords is essential to address a number of
fundamental challenges relating to inference and prediction in complex, high-dimensional
biological problems.
acknowledgement: The authors thank Dario Ringach for providing the V1 receptive fields
and Olivier Marre for providing the retinal receptive fields. W.M. was funded by
the European Union’s Horizon 2020 research and innovation programme under the Marie
Skłodowska-Curie grant agreement no. 754411. M.H. was funded in part by Human Frontiers
Science grant no. HFSP RGP0032/2018.
article_processing_charge: No
author:
- first_name: Wiktor F
full_name: Mlynarski, Wiktor F
id: 358A453A-F248-11E8-B48F-1D18A9856A87
last_name: Mlynarski
- first_name: Michal
full_name: Hledik, Michal
id: 4171253A-F248-11E8-B48F-1D18A9856A87
last_name: Hledik
- first_name: Thomas R
full_name: Sokolowski, Thomas R
id: 3E999752-F248-11E8-B48F-1D18A9856A87
last_name: Sokolowski
orcid: 0000-0002-1287-3779
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
citation:
ama: Mlynarski WF, Hledik M, Sokolowski TR, Tkačik G. Statistical analysis and optimality
of neural systems. Neuron. 2021;109(7):1227-1241.e5. doi:10.1016/j.neuron.2021.01.020
apa: Mlynarski, W. F., Hledik, M., Sokolowski, T. R., & Tkačik, G. (2021). Statistical
analysis and optimality of neural systems. Neuron. Cell Press. https://doi.org/10.1016/j.neuron.2021.01.020
chicago: Mlynarski, Wiktor F, Michal Hledik, Thomas R Sokolowski, and Gašper Tkačik.
“Statistical Analysis and Optimality of Neural Systems.” Neuron. Cell Press,
2021. https://doi.org/10.1016/j.neuron.2021.01.020.
ieee: W. F. Mlynarski, M. Hledik, T. R. Sokolowski, and G. Tkačik, “Statistical
analysis and optimality of neural systems,” Neuron, vol. 109, no. 7. Cell
Press, p. 1227–1241.e5, 2021.
ista: Mlynarski WF, Hledik M, Sokolowski TR, Tkačik G. 2021. Statistical analysis
and optimality of neural systems. Neuron. 109(7), 1227–1241.e5.
mla: Mlynarski, Wiktor F., et al. “Statistical Analysis and Optimality of Neural
Systems.” Neuron, vol. 109, no. 7, Cell Press, 2021, p. 1227–1241.e5, doi:10.1016/j.neuron.2021.01.020.
short: W.F. Mlynarski, M. Hledik, T.R. Sokolowski, G. Tkačik, Neuron 109 (2021)
1227–1241.e5.
date_created: 2020-02-28T11:00:12Z
date_published: 2021-04-07T00:00:00Z
date_updated: 2024-03-06T14:22:51Z
day: '07'
department:
- _id: GaTk
doi: 10.1016/j.neuron.2021.01.020
ec_funded: 1
external_id:
isi:
- '000637809600006'
intvolume: ' 109'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/848374
month: '04'
oa: 1
oa_version: Preprint
page: 1227-1241.e5
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Neuron
publication_status: published
publisher: Cell Press
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/can-evolution-be-predicted/
record:
- id: '15020'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Statistical analysis and optimality of neural systems
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 109
year: '2021'
...
---
_id: '10598'
abstract:
- lang: eng
text: ' We consider the problem of estimating a signal from measurements obtained
via a generalized linear model. We focus on estimators based on approximate message
passing (AMP), a family of iterative algorithms with many appealing features:
the performance of AMP in the high-dimensional limit can be succinctly characterized
under suitable model assumptions; AMP can also be tailored to the empirical distribution
of the signal entries, and for a wide class of estimation problems, AMP is conjectured
to be optimal among all polynomial-time algorithms. However, a major issue of
AMP is that in many models (such as phase retrieval), it requires an initialization
correlated with the ground-truth signal and independent from the measurement matrix.
Assuming that such an initialization is available is typically not realistic.
In this paper, we solve this problem by proposing an AMP algorithm initialized
with a spectral estimator. With such an initialization, the standard AMP analysis
fails since the spectral estimator depends in a complicated way on the design
matrix. Our main contribution is a rigorous characterization of the performance
of AMP with spectral initialization in the high-dimensional limit. The key technical
idea is to define and analyze a two-phase artificial AMP algorithm that first
produces the spectral estimator, and then closely approximates the iterates of
the true AMP. We also provide numerical results that demonstrate the validity
of the proposed approach. '
acknowledgement: The authors would like to thank Andrea Montanari for helpful discussions.
M. Mondelli was partially supported by the 2019 Lopez-Loreta Prize. R. Venkataramanan
was partially supported by the Alan Turing Institute under the EPSRC grant EP/N510129/1.
alternative_title:
- Proceedings of Machine Learning Research
article_processing_charge: Yes (via OA deal)
author:
- first_name: Marco
full_name: Mondelli, Marco
id: 27EB676C-8706-11E9-9510-7717E6697425
last_name: Mondelli
orcid: 0000-0002-3242-7020
- first_name: Ramji
full_name: Venkataramanan, Ramji
last_name: Venkataramanan
citation:
ama: 'Mondelli M, Venkataramanan R. Approximate message passing with spectral initialization
for generalized linear models. In: Banerjee A, Fukumizu K, eds. Proceedings
of The 24th International Conference on Artificial Intelligence and Statistics.
Vol 130. ML Research Press; 2021:397-405.'
apa: 'Mondelli, M., & Venkataramanan, R. (2021). Approximate message passing
with spectral initialization for generalized linear models. In A. Banerjee &
K. Fukumizu (Eds.), Proceedings of The 24th International Conference on Artificial
Intelligence and Statistics (Vol. 130, pp. 397–405). Virtual, San Diego, CA,
United States: ML Research Press.'
chicago: Mondelli, Marco, and Ramji Venkataramanan. “Approximate Message Passing
with Spectral Initialization for Generalized Linear Models.” In Proceedings
of The 24th International Conference on Artificial Intelligence and Statistics,
edited by Arindam Banerjee and Kenji Fukumizu, 130:397–405. ML Research Press,
2021.
ieee: M. Mondelli and R. Venkataramanan, “Approximate message passing with spectral
initialization for generalized linear models,” in Proceedings of The 24th International
Conference on Artificial Intelligence and Statistics, Virtual, San Diego,
CA, United States, 2021, vol. 130, pp. 397–405.
ista: 'Mondelli M, Venkataramanan R. 2021. Approximate message passing with spectral
initialization for generalized linear models. Proceedings of The 24th International
Conference on Artificial Intelligence and Statistics. AISTATS: Artificial Intelligence
and Statistics, Proceedings of Machine Learning Research, vol. 130, 397–405.'
mla: Mondelli, Marco, and Ramji Venkataramanan. “Approximate Message Passing with
Spectral Initialization for Generalized Linear Models.” Proceedings of The
24th International Conference on Artificial Intelligence and Statistics, edited
by Arindam Banerjee and Kenji Fukumizu, vol. 130, ML Research Press, 2021, pp.
397–405.
short: M. Mondelli, R. Venkataramanan, in:, A. Banerjee, K. Fukumizu (Eds.), Proceedings
of The 24th International Conference on Artificial Intelligence and Statistics,
ML Research Press, 2021, pp. 397–405.
conference:
end_date: 2021-04-15
location: Virtual, San Diego, CA, United States
name: 'AISTATS: Artificial Intelligence and Statistics'
start_date: 2021-04-13
date_created: 2022-01-03T11:34:22Z
date_published: 2021-04-01T00:00:00Z
date_updated: 2024-03-07T10:36:53Z
day: '01'
department:
- _id: MaMo
editor:
- first_name: Arindam
full_name: Banerjee, Arindam
last_name: Banerjee
- first_name: Kenji
full_name: Fukumizu, Kenji
last_name: Fukumizu
external_id:
arxiv:
- '2010.03460'
intvolume: ' 130'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://proceedings.mlr.press/v130/mondelli21a.html
month: '04'
oa: 1
oa_version: Preprint
page: 397-405
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
name: Prix Lopez-Loretta 2019 - Marco Mondelli
publication: Proceedings of The 24th International Conference on Artificial Intelligence
and Statistics
publication_identifier:
issn:
- 2640-3498
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
related_material:
record:
- id: '12480'
relation: later_version
status: public
scopus_import: '1'
status: public
title: Approximate message passing with spectral initialization for generalized linear
models
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 130
year: '2021'
...
---
_id: '8196'
abstract:
- lang: eng
text: This paper aims to obtain a strong convergence result for a Douglas–Rachford
splitting method with inertial extrapolation step for finding a zero of the sum
of two set-valued maximal monotone operators without any further assumption of
uniform monotonicity on any of the involved maximal monotone operators. Furthermore,
our proposed method is easy to implement and the inertial factor in our proposed
method is a natural choice. Our method of proof is of independent interest. Finally,
some numerical implementations are given to confirm the theoretical analysis.
acknowledgement: Open access funding provided by Institute of Science and Technology
(IST Austria). The project of Yekini Shehu has received funding from the European
Research Council (ERC) under the European Union’s Seventh Framework Program (FP7—2007–2013)
(Grant Agreement No. 616160). The authors are grateful to the anonymous referees
and the handling Editor for their comments and suggestions which have improved the
earlier version of the manuscript greatly.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Yekini
full_name: Shehu, Yekini
id: 3FC7CB58-F248-11E8-B48F-1D18A9856A87
last_name: Shehu
orcid: 0000-0001-9224-7139
- first_name: Qiao-Li
full_name: Dong, Qiao-Li
last_name: Dong
- first_name: Lu-Lu
full_name: Liu, Lu-Lu
last_name: Liu
- first_name: Jen-Chih
full_name: Yao, Jen-Chih
last_name: Yao
citation:
ama: Shehu Y, Dong Q-L, Liu L-L, Yao J-C. New strong convergence method for the
sum of two maximal monotone operators. Optimization and Engineering. 2021;22:2627-2653.
doi:10.1007/s11081-020-09544-5
apa: Shehu, Y., Dong, Q.-L., Liu, L.-L., & Yao, J.-C. (2021). New strong convergence
method for the sum of two maximal monotone operators. Optimization and Engineering.
Springer Nature. https://doi.org/10.1007/s11081-020-09544-5
chicago: Shehu, Yekini, Qiao-Li Dong, Lu-Lu Liu, and Jen-Chih Yao. “New Strong Convergence
Method for the Sum of Two Maximal Monotone Operators.” Optimization and Engineering.
Springer Nature, 2021. https://doi.org/10.1007/s11081-020-09544-5.
ieee: Y. Shehu, Q.-L. Dong, L.-L. Liu, and J.-C. Yao, “New strong convergence method
for the sum of two maximal monotone operators,” Optimization and Engineering,
vol. 22. Springer Nature, pp. 2627–2653, 2021.
ista: Shehu Y, Dong Q-L, Liu L-L, Yao J-C. 2021. New strong convergence method for
the sum of two maximal monotone operators. Optimization and Engineering. 22, 2627–2653.
mla: Shehu, Yekini, et al. “New Strong Convergence Method for the Sum of Two Maximal
Monotone Operators.” Optimization and Engineering, vol. 22, Springer Nature,
2021, pp. 2627–53, doi:10.1007/s11081-020-09544-5.
short: Y. Shehu, Q.-L. Dong, L.-L. Liu, J.-C. Yao, Optimization and Engineering
22 (2021) 2627–2653.
date_created: 2020-08-03T14:29:57Z
date_published: 2021-02-25T00:00:00Z
date_updated: 2024-03-07T14:39:29Z
day: '25'
ddc:
- '510'
department:
- _id: VlKo
doi: 10.1007/s11081-020-09544-5
ec_funded: 1
external_id:
isi:
- '000559345400001'
file:
- access_level: open_access
content_type: application/pdf
creator: dernst
date_created: 2020-08-03T15:24:39Z
date_updated: 2020-08-03T15:24:39Z
file_id: '8197'
file_name: 2020_OptimizationEngineering_Shehu.pdf
file_size: 2137860
relation: main_file
success: 1
file_date_updated: 2020-08-03T15:24:39Z
has_accepted_license: '1'
intvolume: ' 22'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 2627-2653
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
- _id: 25FBA906-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '616160'
name: 'Discrete Optimization in Computer Vision: Theory and Practice'
publication: Optimization and Engineering
publication_identifier:
eissn:
- 1573-2924
issn:
- 1389-4420
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: New strong convergence method for the sum of two maximal monotone operators
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2021'
...
---
_id: '8911'
abstract:
- lang: eng
text: "In the worldwide endeavor for disruptive quantum technologies, germanium
is emerging as a versatile material to realize devices capable of encoding, processing,
or transmitting quantum information. These devices leverage special properties
of the germanium valence-band states, commonly known as holes, such as their inherently
strong spin-orbit coupling and the ability to host superconducting pairing correlations.
In this Review, we initially introduce the physics of holes in low-dimensional
germanium structures with key insights from a theoretical perspective. We then
examine the material science progress underpinning germanium-based planar heterostructures
and nanowires. We review the most significant experimental results demonstrating
key building blocks for quantum technology, such as an electrically driven universal
quantum gate set with spin qubits in quantum dots and superconductor-semiconductor
devices for hybrid quantum systems. We conclude by identifying the most promising
prospects\r\ntoward scalable quantum information processing. "
acknowledgement: "G.S., M.W.,F.A.Z acknowledge financial support from The Netherlands
Organization for Scientific Research (NWO). F.Z., D.L., G.K. acknowledge funding
from the European Union’s Horizon 2020 research and innovation programme under Grand
Agreement Nr. 862046. G.K. acknowledges funding from FP7 ERC Starting Grant 335497,
FWF Y 715-N30, FWF P-30207. S.D. acknowledges support from the European Union’s
Horizon 2020 program under Grant\r\nAgreement No. 81050 and from the Agence Nationale
de la Recherche through the TOPONANO and CMOSQSPIN projects. J.Z. acknowledges support
from the National Key R&D Program of China (Grant No. 2016YFA0301701) and Strategic
Priority Research Program of CAS (Grant No. XDB30000000). D.L. and C.K. acknowledge
the Swiss National Science Foundation and NCCR QSIT."
article_processing_charge: No
article_type: original
author:
- first_name: Giordano
full_name: Scappucci, Giordano
last_name: Scappucci
- first_name: Christoph
full_name: Kloeffel, Christoph
last_name: Kloeffel
- first_name: Floris A.
full_name: Zwanenburg, Floris A.
last_name: Zwanenburg
- first_name: Daniel
full_name: Loss, Daniel
last_name: Loss
- first_name: Maksym
full_name: Myronov, Maksym
last_name: Myronov
- first_name: Jian-Jun
full_name: Zhang, Jian-Jun
last_name: Zhang
- first_name: Silvano De
full_name: Franceschi, Silvano De
last_name: Franceschi
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
- first_name: Menno
full_name: Veldhorst, Menno
last_name: Veldhorst
citation:
ama: Scappucci G, Kloeffel C, Zwanenburg FA, et al. The germanium quantum information
route. Nature Reviews Materials. 2021;6:926–943. doi:10.1038/s41578-020-00262-z
apa: Scappucci, G., Kloeffel, C., Zwanenburg, F. A., Loss, D., Myronov, M., Zhang,
J.-J., … Veldhorst, M. (2021). The germanium quantum information route. Nature
Reviews Materials. Springer Nature. https://doi.org/10.1038/s41578-020-00262-z
chicago: Scappucci, Giordano, Christoph Kloeffel, Floris A. Zwanenburg, Daniel Loss,
Maksym Myronov, Jian-Jun Zhang, Silvano De Franceschi, Georgios Katsaros, and
Menno Veldhorst. “The Germanium Quantum Information Route.” Nature Reviews
Materials. Springer Nature, 2021. https://doi.org/10.1038/s41578-020-00262-z.
ieee: G. Scappucci et al., “The germanium quantum information route,” Nature
Reviews Materials, vol. 6. Springer Nature, pp. 926–943, 2021.
ista: Scappucci G, Kloeffel C, Zwanenburg FA, Loss D, Myronov M, Zhang J-J, Franceschi
SD, Katsaros G, Veldhorst M. 2021. The germanium quantum information route. Nature
Reviews Materials. 6, 926–943.
mla: Scappucci, Giordano, et al. “The Germanium Quantum Information Route.” Nature
Reviews Materials, vol. 6, Springer Nature, 2021, pp. 926–943, doi:10.1038/s41578-020-00262-z.
short: G. Scappucci, C. Kloeffel, F.A. Zwanenburg, D. Loss, M. Myronov, J.-J. Zhang,
S.D. Franceschi, G. Katsaros, M. Veldhorst, Nature Reviews Materials 6 (2021)
926–943.
date_created: 2020-12-02T10:52:51Z
date_published: 2021-10-01T00:00:00Z
date_updated: 2024-03-07T14:48:57Z
day: '01'
department:
- _id: GeKa
doi: 10.1038/s41578-020-00262-z
ec_funded: 1
external_id:
arxiv:
- '2004.08133'
isi:
- '000600826100003'
intvolume: ' 6'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2004.08133
month: '10'
oa: 1
oa_version: Preprint
page: '926–943 '
project:
- _id: 25517E86-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '335497'
name: Towards Spin qubits and Majorana fermions in Germanium selfassembled hut-wires
- _id: 2552F888-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Y00715
name: Loch Spin-Qubits und Majorana-Fermionen in Germanium
- _id: 2641CE5E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P30207
name: Hole spin orbit qubits in Ge quantum wells
publication: Nature Reviews Materials
publication_identifier:
eissn:
- 2058-8437
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The germanium quantum information route
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2021'
...
---
_id: '8338'
abstract:
- lang: eng
text: Canonical parametrisations of classical confocal coordinate systems are introduced
and exploited to construct non-planar analogues of incircular (IC) nets on individual
quadrics and systems of confocal quadrics. Intimate connections with classical
deformations of quadrics that are isometric along asymptotic lines and circular
cross-sections of quadrics are revealed. The existence of octahedral webs of surfaces
of Blaschke type generated by asymptotic and characteristic lines that are diagonally
related to lines of curvature is proved theoretically and established constructively.
Appropriate samplings (grids) of these webs lead to three-dimensional extensions
of non-planar IC nets. Three-dimensional octahedral grids composed of planes and
spatially extending (checkerboard) IC-nets are shown to arise in connection with
systems of confocal quadrics in Minkowski space. In this context, the Laguerre
geometric notion of conical octahedral grids of planes is introduced. The latter
generalise the octahedral grids derived from systems of confocal quadrics in Minkowski
space. An explicit construction of conical octahedral grids is presented. The
results are accompanied by various illustrations which are based on the explicit
formulae provided by the theory.
acknowledgement: This research was supported by the DFG Collaborative Research Center
TRR 109 “Discretization in Geometry and Dynamics”. W.K.S. was also supported by
the Australian Research Council (DP1401000851). A.V.A. was also supported by the
European Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation programme (Grant Agreement No. 78818 Alpha).
article_processing_charge: No
article_type: original
author:
- first_name: Arseniy
full_name: Akopyan, Arseniy
id: 430D2C90-F248-11E8-B48F-1D18A9856A87
last_name: Akopyan
orcid: 0000-0002-2548-617X
- first_name: Alexander I.
full_name: Bobenko, Alexander I.
last_name: Bobenko
- first_name: Wolfgang K.
full_name: Schief, Wolfgang K.
last_name: Schief
- first_name: Jan
full_name: Techter, Jan
last_name: Techter
citation:
ama: Akopyan A, Bobenko AI, Schief WK, Techter J. On mutually diagonal nets on (confocal)
quadrics and 3-dimensional webs. Discrete and Computational Geometry. 2021;66:938-976.
doi:10.1007/s00454-020-00240-w
apa: Akopyan, A., Bobenko, A. I., Schief, W. K., & Techter, J. (2021). On mutually
diagonal nets on (confocal) quadrics and 3-dimensional webs. Discrete and Computational
Geometry. Springer Nature. https://doi.org/10.1007/s00454-020-00240-w
chicago: Akopyan, Arseniy, Alexander I. Bobenko, Wolfgang K. Schief, and Jan Techter.
“On Mutually Diagonal Nets on (Confocal) Quadrics and 3-Dimensional Webs.” Discrete
and Computational Geometry. Springer Nature, 2021. https://doi.org/10.1007/s00454-020-00240-w.
ieee: A. Akopyan, A. I. Bobenko, W. K. Schief, and J. Techter, “On mutually diagonal
nets on (confocal) quadrics and 3-dimensional webs,” Discrete and Computational
Geometry, vol. 66. Springer Nature, pp. 938–976, 2021.
ista: Akopyan A, Bobenko AI, Schief WK, Techter J. 2021. On mutually diagonal nets
on (confocal) quadrics and 3-dimensional webs. Discrete and Computational Geometry.
66, 938–976.
mla: Akopyan, Arseniy, et al. “On Mutually Diagonal Nets on (Confocal) Quadrics
and 3-Dimensional Webs.” Discrete and Computational Geometry, vol. 66,
Springer Nature, 2021, pp. 938–76, doi:10.1007/s00454-020-00240-w.
short: A. Akopyan, A.I. Bobenko, W.K. Schief, J. Techter, Discrete and Computational
Geometry 66 (2021) 938–976.
date_created: 2020-09-06T22:01:13Z
date_published: 2021-10-01T00:00:00Z
date_updated: 2024-03-07T14:51:11Z
day: '01'
department:
- _id: HeEd
doi: 10.1007/s00454-020-00240-w
ec_funded: 1
external_id:
arxiv:
- '1908.00856'
isi:
- '000564488500002'
intvolume: ' 66'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1908.00856
month: '10'
oa: 1
oa_version: Preprint
page: 938-976
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '788183'
name: Alpha Shape Theory Extended
publication: Discrete and Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: On mutually diagonal nets on (confocal) quadrics and 3-dimensional webs
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2021'
...
---
_id: '7939'
abstract:
- lang: eng
text: "We design fast deterministic algorithms for distance computation in the Congested
Clique model. Our key contributions include:\r\n A (2+ϵ)-approximation for
all-pairs shortest paths in O(log2n/ϵ) rounds on unweighted undirected graphs.
With a small additional additive factor, this also applies for weighted graphs.
This is the first sub-polynomial constant-factor approximation for APSP in this
model.\r\n A (1+ϵ)-approximation for multi-source shortest paths from O(n−−√)
sources in O(log2n/ϵ) rounds on weighted undirected graphs. This is the first
sub-polynomial algorithm obtaining this approximation for a set of sources of
polynomial size.\r\n\r\nOur main techniques are new distance tools that are obtained
via improved algorithms for sparse matrix multiplication, which we leverage to
construct efficient hopsets and shortest paths. Furthermore, our techniques extend
to additional distance problems for which we improve upon the state-of-the-art,
including diameter approximation, and an exact single-source shortest paths algorithm
for weighted undirected graphs in O~(n1/6) rounds. "
acknowledgement: Open access funding provided by Institute of Science and Technology
(IST Austria). We thank Mohsen Ghaffari, Michael Elkin and Merav Parter for fruitful
discussions. This project has received funding from the European Union’s Horizon
2020 Research And Innovation Program under Grant Agreement No. 755839.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Keren
full_name: Censor-Hillel, Keren
last_name: Censor-Hillel
- first_name: Michal
full_name: Dory, Michal
last_name: Dory
- first_name: Janne
full_name: Korhonen, Janne
id: C5402D42-15BC-11E9-A202-CA2BE6697425
last_name: Korhonen
- first_name: Dean
full_name: Leitersdorf, Dean
last_name: Leitersdorf
citation:
ama: Censor-Hillel K, Dory M, Korhonen J, Leitersdorf D. Fast approximate shortest
paths in the congested clique. Distributed Computing. 2021;34:463-487.
doi:10.1007/s00446-020-00380-5
apa: Censor-Hillel, K., Dory, M., Korhonen, J., & Leitersdorf, D. (2021). Fast
approximate shortest paths in the congested clique. Distributed Computing.
Springer Nature. https://doi.org/10.1007/s00446-020-00380-5
chicago: Censor-Hillel, Keren, Michal Dory, Janne Korhonen, and Dean Leitersdorf.
“Fast Approximate Shortest Paths in the Congested Clique.” Distributed Computing.
Springer Nature, 2021. https://doi.org/10.1007/s00446-020-00380-5.
ieee: K. Censor-Hillel, M. Dory, J. Korhonen, and D. Leitersdorf, “Fast approximate
shortest paths in the congested clique,” Distributed Computing, vol. 34.
Springer Nature, pp. 463–487, 2021.
ista: Censor-Hillel K, Dory M, Korhonen J, Leitersdorf D. 2021. Fast approximate
shortest paths in the congested clique. Distributed Computing. 34, 463–487.
mla: Censor-Hillel, Keren, et al. “Fast Approximate Shortest Paths in the Congested
Clique.” Distributed Computing, vol. 34, Springer Nature, 2021, pp. 463–87,
doi:10.1007/s00446-020-00380-5.
short: K. Censor-Hillel, M. Dory, J. Korhonen, D. Leitersdorf, Distributed Computing
34 (2021) 463–487.
date_created: 2020-06-07T22:00:54Z
date_published: 2021-12-01T00:00:00Z
date_updated: 2024-03-07T14:43:39Z
day: '01'
department:
- _id: DaAl
doi: 10.1007/s00446-020-00380-5
external_id:
arxiv:
- '1903.05956'
isi:
- '000556444600001'
intvolume: ' 34'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1007/s00446-020-00380-5
month: '12'
oa: 1
oa_version: Published Version
page: 463-487
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Distributed Computing
publication_identifier:
eissn:
- 1432-0452
issn:
- 0178-2770
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '6933'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Fast approximate shortest paths in the congested clique
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2021'
...
---
_id: '8248'
abstract:
- lang: eng
text: 'We consider the following setting: suppose that we are given a manifold M
in Rd with positive reach. Moreover assume that we have an embedded simplical
complex A without boundary, whose vertex set lies on the manifold, is sufficiently
dense and such that all simplices in A have sufficient quality. We prove that
if, locally, interiors of the projection of the simplices onto the tangent space
do not intersect, then A is a triangulation of the manifold, that is, they are
homeomorphic.'
acknowledgement: "Open access funding provided by the Institute of Science and Technology
(IST Austria). Arijit Ghosh is supported by the Ramanujan Fellowship (No. SB/S2/RJN-064/2015),
India.\r\nThis work has been funded by the European Research Council under the European
Union’s ERC Grant Agreement number 339025 GUDHI (Algorithmic Foundations of Geometric
Understanding in Higher Dimensions). The third author is supported by Ramanujan
Fellowship (No. SB/S2/RJN-064/2015), India. The fifth author also received funding
from the European Union’s Horizon 2020 research and innovation programme under the
Marie Skłodowska-Curie Grant Agreement No. 754411."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Jean-Daniel
full_name: Boissonnat, Jean-Daniel
last_name: Boissonnat
- first_name: Ramsay
full_name: Dyer, Ramsay
last_name: Dyer
- first_name: Arijit
full_name: Ghosh, Arijit
last_name: Ghosh
- first_name: Andre
full_name: Lieutier, Andre
last_name: Lieutier
- first_name: Mathijs
full_name: Wintraecken, Mathijs
id: 307CFBC8-F248-11E8-B48F-1D18A9856A87
last_name: Wintraecken
orcid: 0000-0002-7472-2220
citation:
ama: Boissonnat J-D, Dyer R, Ghosh A, Lieutier A, Wintraecken M. Local conditions
for triangulating submanifolds of Euclidean space. Discrete and Computational
Geometry. 2021;66:666-686. doi:10.1007/s00454-020-00233-9
apa: Boissonnat, J.-D., Dyer, R., Ghosh, A., Lieutier, A., & Wintraecken, M.
(2021). Local conditions for triangulating submanifolds of Euclidean space. Discrete
and Computational Geometry. Springer Nature. https://doi.org/10.1007/s00454-020-00233-9
chicago: Boissonnat, Jean-Daniel, Ramsay Dyer, Arijit Ghosh, Andre Lieutier, and
Mathijs Wintraecken. “Local Conditions for Triangulating Submanifolds of Euclidean
Space.” Discrete and Computational Geometry. Springer Nature, 2021. https://doi.org/10.1007/s00454-020-00233-9.
ieee: J.-D. Boissonnat, R. Dyer, A. Ghosh, A. Lieutier, and M. Wintraecken, “Local
conditions for triangulating submanifolds of Euclidean space,” Discrete and
Computational Geometry, vol. 66. Springer Nature, pp. 666–686, 2021.
ista: Boissonnat J-D, Dyer R, Ghosh A, Lieutier A, Wintraecken M. 2021. Local conditions
for triangulating submanifolds of Euclidean space. Discrete and Computational
Geometry. 66, 666–686.
mla: Boissonnat, Jean-Daniel, et al. “Local Conditions for Triangulating Submanifolds
of Euclidean Space.” Discrete and Computational Geometry, vol. 66, Springer
Nature, 2021, pp. 666–86, doi:10.1007/s00454-020-00233-9.
short: J.-D. Boissonnat, R. Dyer, A. Ghosh, A. Lieutier, M. Wintraecken, Discrete
and Computational Geometry 66 (2021) 666–686.
date_created: 2020-08-11T07:11:51Z
date_published: 2021-09-01T00:00:00Z
date_updated: 2024-03-07T14:54:59Z
day: '01'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1007/s00454-020-00233-9
ec_funded: 1
external_id:
isi:
- '000558119300001'
has_accepted_license: '1'
intvolume: ' 66'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1007/s00454-020-00233-9
month: '09'
oa: 1
oa_version: Published Version
page: 666-686
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Discrete and Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Local conditions for triangulating submanifolds of Euclidean space
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2021'
...
---
_id: '7883'
abstract:
- lang: eng
text: All vertebrates have a spinal cord with dimensions and shape specific to their
species. Yet how species‐specific organ size and shape are achieved is a fundamental
unresolved question in biology. The formation and sculpting of organs begins during
embryonic development. As it develops, the spinal cord extends in anterior–posterior
direction in synchrony with the overall growth of the body. The dorsoventral (DV)
and apicobasal lengths of the spinal cord neuroepithelium also change, while at
the same time a characteristic pattern of neural progenitor subtypes along the
DV axis is established and elaborated. At the basis of these changes in tissue
size and shape are biophysical determinants, such as the change in cell number,
cell size and shape, and anisotropic tissue growth. These processes are controlled
by global tissue‐scale regulators, such as morphogen signaling gradients as well
as mechanical forces. Current challenges in the field are to uncover how these
tissue‐scale regulatory mechanisms are translated to the cellular and molecular
level, and how regulation of distinct cellular processes gives rise to an overall
defined size. Addressing these questions will help not only to achieve a better
understanding of how size is controlled, but also of how tissue size is coordinated
with the specification of pattern.
acknowledgement: 'Austrian Academy of Sciences, Grant/Award Number: DOC fellowship
for Katarzyna Kuzmicz-Kowalska; Austrian Science Fund, Grant/Award Number: F78 (Stem
Cell Modulation); H2020 European Research Council, Grant/Award Number: 680037'
article_number: e383
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Katarzyna
full_name: Kuzmicz-Kowalska, Katarzyna
id: 4CED352A-F248-11E8-B48F-1D18A9856A87
last_name: Kuzmicz-Kowalska
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
citation:
ama: 'Kuzmicz-Kowalska K, Kicheva A. Regulation of size and scale in vertebrate
spinal cord development. Wiley Interdisciplinary Reviews: Developmental Biology.
2021. doi:10.1002/wdev.383'
apa: 'Kuzmicz-Kowalska, K., & Kicheva, A. (2021). Regulation of size and scale
in vertebrate spinal cord development. Wiley Interdisciplinary Reviews: Developmental
Biology. Wiley. https://doi.org/10.1002/wdev.383'
chicago: 'Kuzmicz-Kowalska, Katarzyna, and Anna Kicheva. “Regulation of Size and
Scale in Vertebrate Spinal Cord Development.” Wiley Interdisciplinary Reviews:
Developmental Biology. Wiley, 2021. https://doi.org/10.1002/wdev.383.'
ieee: 'K. Kuzmicz-Kowalska and A. Kicheva, “Regulation of size and scale in vertebrate
spinal cord development,” Wiley Interdisciplinary Reviews: Developmental Biology.
Wiley, 2021.'
ista: 'Kuzmicz-Kowalska K, Kicheva A. 2021. Regulation of size and scale in vertebrate
spinal cord development. Wiley Interdisciplinary Reviews: Developmental Biology.,
e383.'
mla: 'Kuzmicz-Kowalska, Katarzyna, and Anna Kicheva. “Regulation of Size and Scale
in Vertebrate Spinal Cord Development.” Wiley Interdisciplinary Reviews: Developmental
Biology, e383, Wiley, 2021, doi:10.1002/wdev.383.'
short: 'K. Kuzmicz-Kowalska, A. Kicheva, Wiley Interdisciplinary Reviews: Developmental
Biology (2021).'
date_created: 2020-05-24T22:01:00Z
date_published: 2021-04-15T00:00:00Z
date_updated: 2024-03-07T15:03:00Z
day: '15'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1002/wdev.383
ec_funded: 1
external_id:
isi:
- '000531419400001'
pmid:
- '32391980'
file:
- access_level: open_access
checksum: f0a7745d48afa09ea7025e876a0145a8
content_type: application/pdf
creator: dernst
date_created: 2020-11-24T13:11:39Z
date_updated: 2020-11-24T13:11:39Z
file_id: '8800'
file_name: 2020_WIREs_DevBio_KuzmiczKowalska.pdf
file_size: 2527276
relation: main_file
success: 1
file_date_updated: 2020-11-24T13:11:39Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
- _id: 267AF0E4-B435-11E9-9278-68D0E5697425
name: The role of morphogens in the regulation of neural tube growth
- _id: 059DF620-7A3F-11EA-A408-12923DDC885E
grant_number: F07802
name: Morphogen control of growth and pattern in the spinal cord
publication: 'Wiley Interdisciplinary Reviews: Developmental Biology'
publication_identifier:
eissn:
- '17597692'
issn:
- '17597684'
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '14323'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Regulation of size and scale in vertebrate spinal cord development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '7905'
abstract:
- lang: eng
text: We investigate a sheaf-theoretic interpretation of stratification learning
from geometric and topological perspectives. Our main result is the construction
of stratification learning algorithms framed in terms of a sheaf on a partially
ordered set with the Alexandroff topology. We prove that the resulting decomposition
is the unique minimal stratification for which the strata are homogeneous and
the given sheaf is constructible. In particular, when we choose to work with the
local homology sheaf, our algorithm gives an alternative to the local homology
transfer algorithm given in Bendich et al. (Proceedings of the 23rd Annual ACM-SIAM
Symposium on Discrete Algorithms, pp. 1355–1370, ACM, New York, 2012), and the
cohomology stratification algorithm given in Nanda (Found. Comput. Math. 20(2),
195–222, 2020). Additionally, we give examples of stratifications based on the
geometric techniques of Breiding et al. (Rev. Mat. Complut. 31(3), 545–593, 2018),
illustrating how the sheaf-theoretic approach can be used to study stratifications
from both topological and geometric perspectives. This approach also points toward
future applications of sheaf theory in the study of topological data analysis
by illustrating the utility of the language of sheaf theory in generalizing existing
algorithms.
acknowledgement: Open access funding provided by Institute of Science and Technology
(IST Austria). This work was partially supported by NSF IIS-1513616 and NSF ABI-1661375.
The authors would like to thank the anonymous referees for their insightful comments.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Adam
full_name: Brown, Adam
id: 70B7FDF6-608D-11E9-9333-8535E6697425
last_name: Brown
- first_name: Bei
full_name: Wang, Bei
last_name: Wang
citation:
ama: Brown A, Wang B. Sheaf-theoretic stratification learning from geometric and
topological perspectives. Discrete and Computational Geometry. 2021;65:1166-1198.
doi:10.1007/s00454-020-00206-y
apa: Brown, A., & Wang, B. (2021). Sheaf-theoretic stratification learning from
geometric and topological perspectives. Discrete and Computational Geometry.
Springer Nature. https://doi.org/10.1007/s00454-020-00206-y
chicago: Brown, Adam, and Bei Wang. “Sheaf-Theoretic Stratification Learning from
Geometric and Topological Perspectives.” Discrete and Computational Geometry.
Springer Nature, 2021. https://doi.org/10.1007/s00454-020-00206-y.
ieee: A. Brown and B. Wang, “Sheaf-theoretic stratification learning from geometric
and topological perspectives,” Discrete and Computational Geometry, vol.
65. Springer Nature, pp. 1166–1198, 2021.
ista: Brown A, Wang B. 2021. Sheaf-theoretic stratification learning from geometric
and topological perspectives. Discrete and Computational Geometry. 65, 1166–1198.
mla: Brown, Adam, and Bei Wang. “Sheaf-Theoretic Stratification Learning from Geometric
and Topological Perspectives.” Discrete and Computational Geometry, vol.
65, Springer Nature, 2021, pp. 1166–98, doi:10.1007/s00454-020-00206-y.
short: A. Brown, B. Wang, Discrete and Computational Geometry 65 (2021) 1166–1198.
date_created: 2020-05-30T10:26:04Z
date_published: 2021-06-01T00:00:00Z
date_updated: 2024-03-07T15:01:58Z
day: '01'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1007/s00454-020-00206-y
external_id:
arxiv:
- '1712.07734'
isi:
- '000536324700001'
file:
- access_level: open_access
checksum: 487a84ea5841b75f04f66d7ebd71b67e
content_type: application/pdf
creator: dernst
date_created: 2020-11-25T09:06:41Z
date_updated: 2020-11-25T09:06:41Z
file_id: '8803'
file_name: 2020_DiscreteCompGeometry_Brown.pdf
file_size: 1013730
relation: main_file
success: 1
file_date_updated: 2020-11-25T09:06:41Z
has_accepted_license: '1'
intvolume: ' 65'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1166-1198
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Discrete and Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sheaf-theoretic stratification learning from geometric and topological perspectives
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 65
year: '2021'
...
---
_id: '8601'
abstract:
- lang: eng
text: We consider large non-Hermitian real or complex random matrices X with independent,
identically distributed centred entries. We prove that their local eigenvalue
statistics near the spectral edge, the unit circle, coincide with those of the
Ginibre ensemble, i.e. when the matrix elements of X are Gaussian. This result
is the non-Hermitian counterpart of the universality of the Tracy–Widom distribution
at the spectral edges of the Wigner ensemble.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Giorgio
full_name: Cipolloni, Giorgio
id: 42198EFA-F248-11E8-B48F-1D18A9856A87
last_name: Cipolloni
orcid: 0000-0002-4901-7992
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Dominik J
full_name: Schröder, Dominik J
id: 408ED176-F248-11E8-B48F-1D18A9856A87
last_name: Schröder
orcid: 0000-0002-2904-1856
citation:
ama: Cipolloni G, Erdös L, Schröder DJ. Edge universality for non-Hermitian random
matrices. Probability Theory and Related Fields. 2021. doi:10.1007/s00440-020-01003-7
apa: Cipolloni, G., Erdös, L., & Schröder, D. J. (2021). Edge universality for
non-Hermitian random matrices. Probability Theory and Related Fields. Springer
Nature. https://doi.org/10.1007/s00440-020-01003-7
chicago: Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Edge Universality
for Non-Hermitian Random Matrices.” Probability Theory and Related Fields.
Springer Nature, 2021. https://doi.org/10.1007/s00440-020-01003-7.
ieee: G. Cipolloni, L. Erdös, and D. J. Schröder, “Edge universality for non-Hermitian
random matrices,” Probability Theory and Related Fields. Springer Nature,
2021.
ista: Cipolloni G, Erdös L, Schröder DJ. 2021. Edge universality for non-Hermitian
random matrices. Probability Theory and Related Fields.
mla: Cipolloni, Giorgio, et al. “Edge Universality for Non-Hermitian Random Matrices.”
Probability Theory and Related Fields, Springer Nature, 2021, doi:10.1007/s00440-020-01003-7.
short: G. Cipolloni, L. Erdös, D.J. Schröder, Probability Theory and Related Fields
(2021).
date_created: 2020-10-04T22:01:37Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2024-03-07T15:07:53Z
day: '01'
ddc:
- '510'
department:
- _id: LaEr
doi: 10.1007/s00440-020-01003-7
ec_funded: 1
external_id:
arxiv:
- '1908.00969'
isi:
- '000572724600002'
file:
- access_level: open_access
checksum: 611ae28d6055e1e298d53a57beb05ef4
content_type: application/pdf
creator: dernst
date_created: 2020-10-05T14:53:40Z
date_updated: 2020-10-05T14:53:40Z
file_id: '8612'
file_name: 2020_ProbTheory_Cipolloni.pdf
file_size: 497032
relation: main_file
success: 1
file_date_updated: 2020-10-05T14:53:40Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '338804'
name: Random matrices, universality and disordered quantum systems
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Probability Theory and Related Fields
publication_identifier:
eissn:
- '14322064'
issn:
- '01788051'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Edge universality for non-Hermitian random matrices
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '7925'
abstract:
- lang: eng
text: In this paper, we introduce a relaxed CQ method with alternated inertial step
for solving split feasibility problems. We give convergence of the sequence generated
by our method under some suitable assumptions. Some numerical implementations
from sparse signal and image deblurring are reported to show the efficiency of
our method.
acknowledgement: Open access funding provided by Institute of Science and Technology
(IST Austria). The authors are grateful to the referees for their insightful comments
which have improved the earlier version of the manuscript greatly. The first author
has received funding from the European Research Council (ERC) under the European
Union’s Seventh Framework Program (FP7-2007-2013) (Grant agreement No. 616160).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Yekini
full_name: Shehu, Yekini
id: 3FC7CB58-F248-11E8-B48F-1D18A9856A87
last_name: Shehu
orcid: 0000-0001-9224-7139
- first_name: Aviv
full_name: Gibali, Aviv
last_name: Gibali
citation:
ama: Shehu Y, Gibali A. New inertial relaxed method for solving split feasibilities.
Optimization Letters. 2021;15:2109-2126. doi:10.1007/s11590-020-01603-1
apa: Shehu, Y., & Gibali, A. (2021). New inertial relaxed method for solving
split feasibilities. Optimization Letters. Springer Nature. https://doi.org/10.1007/s11590-020-01603-1
chicago: Shehu, Yekini, and Aviv Gibali. “New Inertial Relaxed Method for Solving
Split Feasibilities.” Optimization Letters. Springer Nature, 2021. https://doi.org/10.1007/s11590-020-01603-1.
ieee: Y. Shehu and A. Gibali, “New inertial relaxed method for solving split feasibilities,”
Optimization Letters, vol. 15. Springer Nature, pp. 2109–2126, 2021.
ista: Shehu Y, Gibali A. 2021. New inertial relaxed method for solving split feasibilities.
Optimization Letters. 15, 2109–2126.
mla: Shehu, Yekini, and Aviv Gibali. “New Inertial Relaxed Method for Solving Split
Feasibilities.” Optimization Letters, vol. 15, Springer Nature, 2021, pp.
2109–26, doi:10.1007/s11590-020-01603-1.
short: Y. Shehu, A. Gibali, Optimization Letters 15 (2021) 2109–2126.
date_created: 2020-06-04T11:28:33Z
date_published: 2021-09-01T00:00:00Z
date_updated: 2024-03-07T15:00:43Z
day: '01'
ddc:
- '510'
department:
- _id: VlKo
doi: 10.1007/s11590-020-01603-1
ec_funded: 1
external_id:
isi:
- '000537342300001'
file:
- access_level: open_access
checksum: 63c5f31cd04626152a19f97a2476281b
content_type: application/pdf
creator: kschuh
date_created: 2024-03-07T14:58:51Z
date_updated: 2024-03-07T14:58:51Z
file_id: '15089'
file_name: 2021_OptimizationLetters_Shehu.pdf
file_size: 2148882
relation: main_file
success: 1
file_date_updated: 2024-03-07T14:58:51Z
has_accepted_license: '1'
intvolume: ' 15'
isi: 1
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 2109-2126
project:
- _id: 25FBA906-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '616160'
name: 'Discrete Optimization in Computer Vision: Theory and Practice'
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Optimization Letters
publication_identifier:
eissn:
- 1862-4480
issn:
- 1862-4472
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: New inertial relaxed method for solving split feasibilities
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2021'
...
---
_id: '15151'
abstract:
- lang: eng
text: Eukaryotic DNA-binding proteins operate in the context of chromatin, where
nucleosomes are the elementary building blocks. Nucleosomal DNA is wrapped around
a histone core, thereby rendering a large fraction of the DNA surface inaccessible
to DNA-binding proteins. Nevertheless, first responders in DNA repair and sequence-specific
transcription factors bind DNA target sites obstructed by chromatin. While early
studies examined protein binding to histone-free DNA, it is only now beginning
to emerge how DNA sequences are interrogated on nucleosomes. These readout strategies
range from the release of nucleosomal DNA from histones, to rotational/translation
register shifts of the DNA motif, and nucleosome-specific DNA binding modes that
differ from those observed on naked DNA. Since DNA motif engagement on nucleosomes
strongly depends on position and orientation, we argue that motif location and
nucleosome positioning co-determine protein access to DNA in transcription and
DNA repair.
article_processing_charge: No
article_type: review
author:
- first_name: Alicia
full_name: Michael, Alicia
id: 6437c950-2a03-11ee-914d-d6476dd7b75c
last_name: Michael
orcid: 0000-0002-6080-839X
- first_name: Nicolas H.
full_name: Thomä, Nicolas H.
last_name: Thomä
citation:
ama: Michael AK, Thomä NH. Reading the chromatinized genome. Cell. 2021;184(14):3599-3611.
doi:10.1016/j.cell.2021.05.029
apa: Michael, A. K., & Thomä, N. H. (2021). Reading the chromatinized genome.
Cell. Elsevier. https://doi.org/10.1016/j.cell.2021.05.029
chicago: Michael, Alicia K., and Nicolas H. Thomä. “Reading the Chromatinized Genome.”
Cell. Elsevier, 2021. https://doi.org/10.1016/j.cell.2021.05.029.
ieee: A. K. Michael and N. H. Thomä, “Reading the chromatinized genome,” Cell,
vol. 184, no. 14. Elsevier, pp. 3599–3611, 2021.
ista: Michael AK, Thomä NH. 2021. Reading the chromatinized genome. Cell. 184(14),
3599–3611.
mla: Michael, Alicia K., and Nicolas H. Thomä. “Reading the Chromatinized Genome.”
Cell, vol. 184, no. 14, Elsevier, 2021, pp. 3599–611, doi:10.1016/j.cell.2021.05.029.
short: A.K. Michael, N.H. Thomä, Cell 184 (2021) 3599–3611.
date_created: 2024-03-21T07:54:19Z
date_published: 2021-07-08T00:00:00Z
date_updated: 2024-03-25T12:31:39Z
day: '08'
doi: 10.1016/j.cell.2021.05.029
extern: '1'
intvolume: ' 184'
issue: '14'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cell.2021.05.029
month: '07'
oa: 1
oa_version: Published Version
page: 3599-3611
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reading the chromatinized genome
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 184
year: '2021'
...
---
_id: '9438'
abstract:
- lang: eng
text: Rigorous investigation of synaptic transmission requires analysis of unitary
synaptic events by simultaneous recording from presynaptic terminals and postsynaptic
target neurons. However, this has been achieved at only a limited number of model
synapses, including the squid giant synapse and the mammalian calyx of Held. Cortical
presynaptic terminals have been largely inaccessible to direct presynaptic recording,
due to their small size. Here, we describe a protocol for improved subcellular
patch-clamp recording in rat and mouse brain slices, with the synapse in a largely
intact environment. Slice preparation takes ~2 h, recording ~3 h and post hoc
morphological analysis 2 d. Single presynaptic hippocampal mossy fiber terminals
are stimulated minimally invasively in the bouton-attached configuration, in which
the cytoplasmic content remains unperturbed, or in the whole-bouton configuration,
in which the cytoplasmic composition can be precisely controlled. Paired pre–postsynaptic
recordings can be integrated with biocytin labeling and morphological analysis,
allowing correlative investigation of synapse structure and function. Paired recordings
can be obtained from mossy fiber terminals in slices from both rats and mice,
implying applicability to genetically modified synapses. Paired recordings can
also be performed together with axon tract stimulation or optogenetic activation,
allowing comparison of unitary and compound synaptic events in the same target
cell. Finally, paired recordings can be combined with spontaneous event analysis,
permitting collection of miniature events generated at a single identified synapse.
In conclusion, the subcellular patch-clamp techniques detailed here should facilitate
analysis of biophysics, plasticity and circuit function of cortical synapses in
the mammalian central nervous system.
acknowledged_ssus:
- _id: M-Shop
acknowledgement: This project received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement no. 692692 to P.J.) and the Fond zur Förderung der Wissenschaftlichen
Forschung (Z 312-B27, Wittgenstein award to P.J., V 739-B27 to C.B.M.). We are grateful
to F. Marr and C. Altmutter for excellent technical assistance and cell reconstruction,
E. Kralli-Beller for manuscript editing, and the Scientific Service Units of IST
Austria, especially T. Asenov and Miba machine shop, for maximally efficient support.
article_processing_charge: No
article_type: original
author:
- first_name: David H
full_name: Vandael, David H
id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87
last_name: Vandael
orcid: 0000-0001-7577-1676
- first_name: Yuji
full_name: Okamoto, Yuji
id: 3337E116-F248-11E8-B48F-1D18A9856A87
last_name: Okamoto
orcid: 0000-0003-0408-6094
- first_name: Carolina
full_name: Borges Merjane, Carolina
id: 4305C450-F248-11E8-B48F-1D18A9856A87
last_name: Borges Merjane
orcid: 0000-0003-0005-401X
- first_name: Victor M
full_name: Vargas Barroso, Victor M
id: 2F55A9DE-F248-11E8-B48F-1D18A9856A87
last_name: Vargas Barroso
- first_name: Benjamin
full_name: Suter, Benjamin
id: 4952F31E-F248-11E8-B48F-1D18A9856A87
last_name: Suter
orcid: 0000-0002-9885-6936
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Vandael DH, Okamoto Y, Borges Merjane C, Vargas Barroso VM, Suter B, Jonas
PM. Subcellular patch-clamp techniques for single-bouton stimulation and simultaneous
pre- and postsynaptic recording at cortical synapses. Nature Protocols.
2021;16(6):2947–2967. doi:10.1038/s41596-021-00526-0
apa: Vandael, D. H., Okamoto, Y., Borges Merjane, C., Vargas Barroso, V. M., Suter,
B., & Jonas, P. M. (2021). Subcellular patch-clamp techniques for single-bouton
stimulation and simultaneous pre- and postsynaptic recording at cortical synapses.
Nature Protocols. Springer Nature. https://doi.org/10.1038/s41596-021-00526-0
chicago: Vandael, David H, Yuji Okamoto, Carolina Borges Merjane, Victor M Vargas
Barroso, Benjamin Suter, and Peter M Jonas. “Subcellular Patch-Clamp Techniques
for Single-Bouton Stimulation and Simultaneous Pre- and Postsynaptic Recording
at Cortical Synapses.” Nature Protocols. Springer Nature, 2021. https://doi.org/10.1038/s41596-021-00526-0.
ieee: D. H. Vandael, Y. Okamoto, C. Borges Merjane, V. M. Vargas Barroso, B. Suter,
and P. M. Jonas, “Subcellular patch-clamp techniques for single-bouton stimulation
and simultaneous pre- and postsynaptic recording at cortical synapses,” Nature
Protocols, vol. 16, no. 6. Springer Nature, pp. 2947–2967, 2021.
ista: Vandael DH, Okamoto Y, Borges Merjane C, Vargas Barroso VM, Suter B, Jonas
PM. 2021. Subcellular patch-clamp techniques for single-bouton stimulation and
simultaneous pre- and postsynaptic recording at cortical synapses. Nature Protocols.
16(6), 2947–2967.
mla: Vandael, David H., et al. “Subcellular Patch-Clamp Techniques for Single-Bouton
Stimulation and Simultaneous Pre- and Postsynaptic Recording at Cortical Synapses.”
Nature Protocols, vol. 16, no. 6, Springer Nature, 2021, pp. 2947–2967,
doi:10.1038/s41596-021-00526-0.
short: D.H. Vandael, Y. Okamoto, C. Borges Merjane, V.M. Vargas Barroso, B. Suter,
P.M. Jonas, Nature Protocols 16 (2021) 2947–2967.
date_created: 2021-05-30T22:01:24Z
date_published: 2021-06-01T00:00:00Z
date_updated: 2023-08-10T22:30:51Z
day: '01'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1038/s41596-021-00526-0
ec_funded: 1
external_id:
isi:
- '000650528700003'
pmid:
- '33990799'
file:
- access_level: open_access
checksum: 7eb580abd8893cdb0b410cf41bc8c263
content_type: application/pdf
creator: cziletti
date_created: 2021-07-08T12:27:55Z
date_updated: 2021-12-02T23:30:05Z
embargo: 2021-12-01
file_id: '9639'
file_name: VandaeletalAuthorVersion2021.pdf
file_size: 38574802
relation: main_file
file_date_updated: 2021-12-02T23:30:05Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 2947–2967
pmid: 1
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: The Wittgenstein Prize
- _id: 2696E7FE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: V00739
name: Structural plasticity at mossy fiber-CA3 synapses
publication: Nature Protocols
publication_identifier:
eissn:
- '17502799'
issn:
- '17542189'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Subcellular patch-clamp techniques for single-bouton stimulation and simultaneous
pre- and postsynaptic recording at cortical synapses
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 16
year: '2021'
...
---
_id: '9992'
abstract:
- lang: eng
text: "Blood – this is what animals use to heal wounds fast and efficient. Plants
do not have blood circulation and their cells cannot move. However, plants have
evolved remarkable capacities to regenerate tissues and organs preventing further
damage. In my PhD research, I studied the wound healing in the Arabidopsis root.
I used a UV laser to ablate single cells in the root tip and observed the consequent
wound healing. Interestingly, the inner adjacent cells induced a\r\ndivision plane
switch and subsequently adopted the cell type of the killed cell to replace it.
We termed this form of wound healing “restorative divisions”. This initial observation
triggered the questions of my PhD studies: How and why do cells orient their division
planes, how do they feel the wound and why does this happen only in inner adjacent
cells.\r\nFor answering these questions, I used a quite simple experimental setup:
5 day - old seedlings were stained with propidium iodide to visualize cell walls
and dead cells; ablation was carried out using a special laser cutter and a confocal
microscope. Adaptation of the novel vertical microscope system made it possible
to observe wounds in real time. This revealed that restorative divisions occur
at increased frequency compared to normal divisions. Additionally,\r\nthe major
plant hormone auxin accumulates in wound adjacent cells and drives the expression
of the wound-stress responsive transcription factor ERF115. Using this as a marker
gene for wound responses, we found that an important part of wound signalling
is the sensing of the collapse of the ablated cell. The collapse causes a radical
pressure drop, which results in strong tissue deformations. These deformations
manifest in an invasion of the now free spot specifically by the inner adjacent
cells within seconds, probably because of higher pressure of the inner tissues.
Long-term imaging revealed that those deformed cells continuously expand towards
the wound hole and that this is crucial for the restorative division. These wound-expanding
cells exhibit an abnormal, biphasic polarity of microtubule arrays\r\nbefore the
division. Experiments inhibiting cell expansion suggest that it is the biphasic
stretching that induces those MT arrays. Adapting the micromanipulator aspiration
system from animal scientists at our institute confirmed the hypothesis that stretching
influences microtubule stability. In conclusion, this shows that microtubules
react to tissue deformation\r\nand this facilitates the observed division plane
switch. This puts mechanical cues and tensions at the most prominent position
for explaining the growth and wound healing properties of plants. Hence, it shines
light onto the importance of understanding mechanical signal transduction. "
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Lukas
full_name: Hörmayer, Lukas
id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87
last_name: Hörmayer
orcid: 0000-0001-8295-2926
citation:
ama: Hörmayer L. Wound healing in the Arabidopsis root meristem. 2021. doi:10.15479/at:ista:9992
apa: Hörmayer, L. (2021). Wound healing in the Arabidopsis root meristem.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:9992
chicago: Hörmayer, Lukas. “Wound Healing in the Arabidopsis Root Meristem.” Institute
of Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:9992.
ieee: L. Hörmayer, “Wound healing in the Arabidopsis root meristem,” Institute of
Science and Technology Austria, 2021.
ista: Hörmayer L. 2021. Wound healing in the Arabidopsis root meristem. Institute
of Science and Technology Austria.
mla: Hörmayer, Lukas. Wound Healing in the Arabidopsis Root Meristem. Institute
of Science and Technology Austria, 2021, doi:10.15479/at:ista:9992.
short: L. Hörmayer, Wound Healing in the Arabidopsis Root Meristem, Institute of
Science and Technology Austria, 2021.
date_created: 2021-09-09T07:37:20Z
date_published: 2021-09-13T00:00:00Z
date_updated: 2023-09-07T13:38:33Z
day: '13'
ddc:
- '575'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JiFr
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oa: 1
oa_version: Published Version
page: '168'
project:
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call_identifier: FWF
grant_number: P29988
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call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
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- 2663-337X
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publisher: Institute of Science and Technology Austria
related_material:
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status: public
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- id: '8002'
relation: part_of_dissertation
status: public
status: public
supervisor:
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full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
title: Wound healing in the Arabidopsis root meristem
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legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '10816'
abstract:
- lang: eng
text: Pattern separation is a fundamental brain computation that converts small
differences in input patterns into large differences in output patterns. Several
synaptic mechanisms of pattern separation have been proposed, including code expansion,
inhibition and plasticity; however, which of these mechanisms play a role in the
entorhinal cortex (EC)–dentate gyrus (DG)–CA3 circuit, a classical pattern separation
circuit, remains unclear. Here we show that a biologically realistic, full-scale
EC–DG–CA3 circuit model, including granule cells (GCs) and parvalbumin-positive
inhibitory interneurons (PV+-INs) in the DG, is an efficient pattern separator.
Both external gamma-modulated inhibition and internal lateral inhibition mediated
by PV+-INs substantially contributed to pattern separation. Both local connectivity
and fast signaling at GC–PV+-IN synapses were important for maximum effectiveness.
Similarly, mossy fiber synapses with conditional detonator properties contributed
to pattern separation. By contrast, perforant path synapses with Hebbian synaptic
plasticity and direct EC–CA3 connection shifted the network towards pattern completion.
Our results demonstrate that the specific properties of cells and synapses optimize
higher-order computations in biological networks and might be useful to improve
the deep learning capabilities of technical networks.
acknowledged_ssus:
- _id: SSU
acknowledgement: We thank A. Aertsen, N. Kopell, W. Maass, A. Roth, F. Stella and
T. Vogels for critically reading earlier versions of the manuscript. We are grateful
to F. Marr and C. Altmutter for excellent technical assistance, E. Kralli-Beller
for manuscript editing, and the Scientific Service Units of IST Austria for efficient
support. Finally, we thank T. Carnevale, L. Erdös, M. Hines, D. Nykamp and D. Schröder
for useful discussions, and R. Friedrich and S. Wiechert for sharing unpublished
data. This project received funding from the European Research Council (ERC) under
the European Union’s Horizon 2020 research and innovation programme (grant agreement
no. 692692, P.J.) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z
312-B27, Wittgenstein award to P.J. and P 31815 to S.J.G.).
article_processing_charge: No
article_type: original
author:
- first_name: José
full_name: Guzmán, José
id: 30CC5506-F248-11E8-B48F-1D18A9856A87
last_name: Guzmán
orcid: 0000-0003-2209-5242
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
- first_name: 'Claudia '
full_name: 'Espinoza Martinez, Claudia '
id: 31FFEE2E-F248-11E8-B48F-1D18A9856A87
last_name: Espinoza Martinez
orcid: 0000-0003-4710-2082
- first_name: Xiaomin
full_name: Zhang, Xiaomin
id: 423EC9C2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
- first_name: Benjamin
full_name: Suter, Benjamin
id: 4952F31E-F248-11E8-B48F-1D18A9856A87
last_name: Suter
orcid: 0000-0002-9885-6936
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Guzmán J, Schlögl A, Espinoza Martinez C, Zhang X, Suter B, Jonas PM. How connectivity
rules and synaptic properties shape the efficacy of pattern separation in the
entorhinal cortex–dentate gyrus–CA3 network. Nature Computational Science.
2021;1(12):830-842. doi:10.1038/s43588-021-00157-1
apa: Guzmán, J., Schlögl, A., Espinoza Martinez, C., Zhang, X., Suter, B., &
Jonas, P. M. (2021). How connectivity rules and synaptic properties shape the
efficacy of pattern separation in the entorhinal cortex–dentate gyrus–CA3 network.
Nature Computational Science. Springer Nature. https://doi.org/10.1038/s43588-021-00157-1
chicago: Guzmán, José, Alois Schlögl, Claudia Espinoza Martinez, Xiaomin Zhang,
Benjamin Suter, and Peter M Jonas. “How Connectivity Rules and Synaptic Properties
Shape the Efficacy of Pattern Separation in the Entorhinal Cortex–Dentate Gyrus–CA3
Network.” Nature Computational Science. Springer Nature, 2021. https://doi.org/10.1038/s43588-021-00157-1.
ieee: J. Guzmán, A. Schlögl, C. Espinoza Martinez, X. Zhang, B. Suter, and P. M.
Jonas, “How connectivity rules and synaptic properties shape the efficacy of pattern
separation in the entorhinal cortex–dentate gyrus–CA3 network,” Nature Computational
Science, vol. 1, no. 12. Springer Nature, pp. 830–842, 2021.
ista: Guzmán J, Schlögl A, Espinoza Martinez C, Zhang X, Suter B, Jonas PM. 2021.
How connectivity rules and synaptic properties shape the efficacy of pattern separation
in the entorhinal cortex–dentate gyrus–CA3 network. Nature Computational Science.
1(12), 830–842.
mla: Guzmán, José, et al. “How Connectivity Rules and Synaptic Properties Shape
the Efficacy of Pattern Separation in the Entorhinal Cortex–Dentate Gyrus–CA3
Network.” Nature Computational Science, vol. 1, no. 12, Springer Nature,
2021, pp. 830–42, doi:10.1038/s43588-021-00157-1.
short: J. Guzmán, A. Schlögl, C. Espinoza Martinez, X. Zhang, B. Suter, P.M. Jonas,
Nature Computational Science 1 (2021) 830–842.
date_created: 2022-03-04T08:32:36Z
date_published: 2021-12-16T00:00:00Z
date_updated: 2023-08-10T22:30:10Z
day: '16'
ddc:
- '610'
department:
- _id: PeJo
doi: 10.1038/s43588-021-00157-1
ec_funded: 1
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file_date_updated: 2022-06-18T22:30:03Z
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intvolume: ' 1'
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keyword:
- general medicine
language:
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month: '12'
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page: 830-842
project:
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call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
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call_identifier: FWF
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name: The Wittgenstein Prize
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issn:
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publisher: Springer Nature
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related_material:
link:
- relation: press_release
url: https://ista.ac.at/en/news/spot-the-difference/
record:
- id: '10110'
relation: software
status: public
scopus_import: '1'
status: public
title: How connectivity rules and synaptic properties shape the efficacy of pattern
separation in the entorhinal cortex–dentate gyrus–CA3 network
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2021'
...
---
_id: '10110'
abstract:
- lang: eng
text: Pattern separation is a fundamental brain computation that converts small
differences in input patterns into large differences in output patterns. Several
synaptic mechanisms of pattern separation have been proposed, including code expansion,
inhibition and plasticity; however, which of these mechanisms play a role in the
entorhinal cortex (EC)–dentate gyrus (DG)–CA3 circuit, a classical pattern separation
circuit, remains unclear. Here we show that a biologically realistic, full-scale
EC–DG–CA3 circuit model, including granule cells (GCs) and parvalbumin-positive
inhibitory interneurons (PV+-INs) in the DG, is an efficient pattern separator.
Both external gamma-modulated inhibition and internal lateral inhibition mediated
by PV+-INs substantially contributed to pattern separation. Both local connectivity
and fast signaling at GC–PV+-IN synapses were important for maximum effectiveness.
Similarly, mossy fiber synapses with conditional detonator properties contributed
to pattern separation. By contrast, perforant path synapses with Hebbian synaptic
plasticity and direct EC–CA3 connection shifted the network towards pattern completion.
Our results demonstrate that the specific properties of cells and synapses optimize
higher-order computations in biological networks and might be useful to improve
the deep learning capabilities of technical networks.
author:
- first_name: José
full_name: Guzmán, José
id: 30CC5506-F248-11E8-B48F-1D18A9856A87
last_name: Guzmán
orcid: 0000-0003-2209-5242
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
- first_name: 'Claudia '
full_name: 'Espinoza Martinez, Claudia '
id: 31FFEE2E-F248-11E8-B48F-1D18A9856A87
last_name: Espinoza Martinez
orcid: 0000-0003-4710-2082
- first_name: Xiaomin
full_name: Zhang, Xiaomin
id: 423EC9C2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
- first_name: Benjamin
full_name: Suter, Benjamin
id: 4952F31E-F248-11E8-B48F-1D18A9856A87
last_name: Suter
orcid: 0000-0002-9885-6936
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Guzmán J, Schlögl A, Espinoza Martinez C, Zhang X, Suter B, Jonas PM. How connectivity
rules and synaptic properties shape the efficacy of pattern separation in the
entorhinal cortex–dentate gyrus–CA3 network. 2021. doi:10.15479/AT:ISTA:10110
apa: Guzmán, J., Schlögl, A., Espinoza Martinez, C., Zhang, X., Suter, B., &
Jonas, P. M. (2021). How connectivity rules and synaptic properties shape the
efficacy of pattern separation in the entorhinal cortex–dentate gyrus–CA3 network.
IST Austria. https://doi.org/10.15479/AT:ISTA:10110
chicago: Guzmán, José, Alois Schlögl, Claudia Espinoza Martinez, Xiaomin Zhang,
Benjamin Suter, and Peter M Jonas. “How Connectivity Rules and Synaptic Properties
Shape the Efficacy of Pattern Separation in the Entorhinal Cortex–Dentate Gyrus–CA3
Network.” IST Austria, 2021. https://doi.org/10.15479/AT:ISTA:10110.
ieee: J. Guzmán, A. Schlögl, C. Espinoza Martinez, X. Zhang, B. Suter, and P. M.
Jonas, “How connectivity rules and synaptic properties shape the efficacy of pattern
separation in the entorhinal cortex–dentate gyrus–CA3 network.” IST Austria, 2021.
ista: Guzmán J, Schlögl A, Espinoza Martinez C, Zhang X, Suter B, Jonas PM. 2021.
How connectivity rules and synaptic properties shape the efficacy of pattern separation
in the entorhinal cortex–dentate gyrus–CA3 network, IST Austria, 10.15479/AT:ISTA:10110.
mla: Guzmán, José, et al. How Connectivity Rules and Synaptic Properties Shape
the Efficacy of Pattern Separation in the Entorhinal Cortex–Dentate Gyrus–CA3
Network. IST Austria, 2021, doi:10.15479/AT:ISTA:10110.
short: J. Guzmán, A. Schlögl, C. Espinoza Martinez, X. Zhang, B. Suter, P.M. Jonas,
(2021).
date_created: 2021-10-08T06:44:22Z
date_published: 2021-12-16T00:00:00Z
date_updated: 2024-03-27T23:30:11Z
day: '16'
ddc:
- '005'
department:
- _id: PeJo
- _id: ScienComp
doi: 10.15479/AT:ISTA:10110
file:
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content_type: application/x-zip-compressed
creator: cchlebak
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date_updated: 2021-10-08T08:46:04Z
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relation: main_file
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file_date_updated: 2021-10-08T08:46:04Z
has_accepted_license: '1'
license: https://opensource.org/licenses/GPL-3.0
month: '12'
oa: 1
publisher: IST Austria
related_material:
link:
- description: News on IST Webpage
relation: press_release
url: https://ist.ac.at/en/news/spot-the-difference/
record:
- id: '10816'
relation: used_for_analysis_in
status: public
status: public
title: How connectivity rules and synaptic properties shape the efficacy of pattern
separation in the entorhinal cortex–dentate gyrus–CA3 network
tmp:
legal_code_url: https://www.gnu.org/licenses/gpl-3.0.en.html
name: GNU General Public License 3.0
short: GPL 3.0
type: software
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '10077'
abstract:
- lang: eng
text: Although much is known about how single neurons in the hippocampus represent
an animal’s position, how cell-cell interactions contribute to spatial coding
remains poorly understood. Using a novel statistical estimator and theoretical
modeling, both developed in the framework of maximum entropy models, we reveal
highly structured cell-to-cell interactions whose statistics depend on familiar
vs. novel environment. In both conditions the circuit interactions optimize the
encoding of spatial information, but for regimes that differ in the signal-to-noise
ratio of their spatial inputs. Moreover, the topology of the interactions facilitates
linear decodability, making the information easy to read out by downstream circuits.
These findings suggest that the efficient coding hypothesis is not applicable
only to individual neuron properties in the sensory periphery, but also to neural
interactions in the central brain.
acknowledgement: We thank Peter Baracskay, Karola Kaefer and Hugo Malagon-Vina for
the acquisition of the data. We thank Federico Stella for comments on an earlier
version of the manuscript. MN was supported by European Union Horizon 2020 grant
665385, JC was supported by European Research Council consolidator grant 281511,
GT was supported by the Austrian Science Fund (FWF) grant P34015, CS was supported
by an IST fellow grant, National Institute of Mental Health Award 1R01MH125571-01,
by the National Science Foundation under NSF Award No. 1922658 and a Google faculty
award.
article_processing_charge: No
author:
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Cristina
full_name: Savin, Cristina
id: 3933349E-F248-11E8-B48F-1D18A9856A87
last_name: Savin
citation:
ama: Nardin M, Csicsvari JL, Tkačik G, Savin C. The structure of hippocampal CA1
interactions optimizes spatial coding across experience. bioRxiv. doi:10.1101/2021.09.28.460602
apa: Nardin, M., Csicsvari, J. L., Tkačik, G., & Savin, C. (n.d.). The structure
of hippocampal CA1 interactions optimizes spatial coding across experience. bioRxiv.
Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.09.28.460602
chicago: Nardin, Michele, Jozsef L Csicsvari, Gašper Tkačik, and Cristina Savin.
“The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across
Experience.” BioRxiv. Cold Spring Harbor Laboratory, n.d. https://doi.org/10.1101/2021.09.28.460602.
ieee: M. Nardin, J. L. Csicsvari, G. Tkačik, and C. Savin, “The structure of hippocampal
CA1 interactions optimizes spatial coding across experience,” bioRxiv.
Cold Spring Harbor Laboratory.
ista: Nardin M, Csicsvari JL, Tkačik G, Savin C. The structure of hippocampal CA1
interactions optimizes spatial coding across experience. bioRxiv, 10.1101/2021.09.28.460602.
mla: Nardin, Michele, et al. “The Structure of Hippocampal CA1 Interactions Optimizes
Spatial Coding across Experience.” BioRxiv, Cold Spring Harbor Laboratory,
doi:10.1101/2021.09.28.460602.
short: M. Nardin, J.L. Csicsvari, G. Tkačik, C. Savin, BioRxiv (n.d.).
date_created: 2021-10-04T06:23:34Z
date_published: 2021-09-29T00:00:00Z
date_updated: 2024-03-27T23:30:16Z
day: '29'
department:
- _id: GradSch
- _id: JoCs
- _id: GaTk
doi: 10.1101/2021.09.28.460602
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2021.09.28.460602
month: '09'
oa: 1
oa_version: Preprint
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 626c45b5-2b32-11ec-9570-e509828c1ba6
grant_number: P34015
name: Efficient coding with biophysical realism
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
related_material:
record:
- id: '11932'
relation: dissertation_contains
status: public
status: public
title: The structure of hippocampal CA1 interactions optimizes spatial coding across
experience
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '9250'
abstract:
- lang: eng
text: Aprotic alkali metal–O2 batteries face two major obstacles to their chemistry
occurring efficiently, the insulating nature of the formed alkali superoxides/peroxides
and parasitic reactions that are caused by the highly reactive singlet oxygen
(1O2). Redox mediators are recognized to be key for improving rechargeability.
However, it is unclear how they affect 1O2 formation, which hinders strategies
for their improvement. Here we clarify the mechanism of mediated peroxide and
superoxide oxidation and thus explain how redox mediators either enhance or suppress
1O2 formation. We show that charging commences with peroxide oxidation to a superoxide
intermediate and that redox potentials above ~3.5 V versus Li/Li+ drive 1O2 evolution
from superoxide oxidation, while disproportionation always generates some 1O2.
We find that 1O2 suppression requires oxidation to be faster than the generation
of 1O2 from disproportionation. Oxidation rates decrease with growing driving
force following Marcus inverted-region behaviour, establishing a region of maximum
rate.
acknowledged_ssus:
- _id: M-Shop
acknowledgement: S.A.F. is indebted to the European Research Council (ERC) under the
European Union’s Horizon 2020 research and innovation programme (grant agreement
No. 636069) as well as IST Austria. O.F thanks the French National Research Agency
(STORE-EX Labex Project ANR-10-LABX-76-01). We thank EL-Cell GmbH (Hamburg, Germany)
for the pressure test cell. We thank R. Saf for help with the mass spectrometry,
J. Schlegl for manufacturing instrumentation, M. Winkler of Acib GmbH, G. Strohmeier
and R. Fürst for HPLC measurements and S. Mondal and S. Stadlbauer for kinetic measurements.
article_processing_charge: No
article_type: original
author:
- first_name: Yann K.
full_name: Petit, Yann K.
last_name: Petit
- first_name: Eléonore
full_name: Mourad, Eléonore
last_name: Mourad
- first_name: Christian
full_name: Prehal, Christian
last_name: Prehal
- first_name: Christian
full_name: Leypold, Christian
last_name: Leypold
- first_name: Andreas
full_name: Windischbacher, Andreas
last_name: Windischbacher
- first_name: Daniel
full_name: Mijailovic, Daniel
last_name: Mijailovic
- first_name: Christian
full_name: Slugovc, Christian
last_name: Slugovc
- first_name: Sergey M.
full_name: Borisov, Sergey M.
last_name: Borisov
- first_name: Egbert
full_name: Zojer, Egbert
last_name: Zojer
- first_name: Sergio
full_name: Brutti, Sergio
last_name: Brutti
- first_name: Olivier
full_name: Fontaine, Olivier
last_name: Fontaine
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Petit YK, Mourad E, Prehal C, et al. Mechanism of mediated alkali peroxide
oxidation and triplet versus singlet oxygen formation. Nature Chemistry.
2021;13(5):465-471. doi:10.1038/s41557-021-00643-z
apa: Petit, Y. K., Mourad, E., Prehal, C., Leypold, C., Windischbacher, A., Mijailovic,
D., … Freunberger, S. A. (2021). Mechanism of mediated alkali peroxide oxidation
and triplet versus singlet oxygen formation. Nature Chemistry. Springer
Nature. https://doi.org/10.1038/s41557-021-00643-z
chicago: Petit, Yann K., Eléonore Mourad, Christian Prehal, Christian Leypold, Andreas
Windischbacher, Daniel Mijailovic, Christian Slugovc, et al. “Mechanism of Mediated
Alkali Peroxide Oxidation and Triplet versus Singlet Oxygen Formation.” Nature
Chemistry. Springer Nature, 2021. https://doi.org/10.1038/s41557-021-00643-z.
ieee: Y. K. Petit et al., “Mechanism of mediated alkali peroxide oxidation
and triplet versus singlet oxygen formation,” Nature Chemistry, vol. 13,
no. 5. Springer Nature, pp. 465–471, 2021.
ista: Petit YK, Mourad E, Prehal C, Leypold C, Windischbacher A, Mijailovic D, Slugovc
C, Borisov SM, Zojer E, Brutti S, Fontaine O, Freunberger SA. 2021. Mechanism
of mediated alkali peroxide oxidation and triplet versus singlet oxygen formation.
Nature Chemistry. 13(5), 465–471.
mla: Petit, Yann K., et al. “Mechanism of Mediated Alkali Peroxide Oxidation and
Triplet versus Singlet Oxygen Formation.” Nature Chemistry, vol. 13, no.
5, Springer Nature, 2021, pp. 465–71, doi:10.1038/s41557-021-00643-z.
short: Y.K. Petit, E. Mourad, C. Prehal, C. Leypold, A. Windischbacher, D. Mijailovic,
C. Slugovc, S.M. Borisov, E. Zojer, S. Brutti, O. Fontaine, S.A. Freunberger,
Nature Chemistry 13 (2021) 465–471.
date_created: 2021-03-16T11:12:20Z
date_published: 2021-03-15T00:00:00Z
date_updated: 2023-09-05T15:34:44Z
day: '15'
ddc:
- '540'
department:
- _id: StFr
doi: 10.1038/s41557-021-00643-z
external_id:
isi:
- '000629296400001'
pmid:
- '33723377'
file:
- access_level: open_access
checksum: 3ee3f8dd79ed1b7bb0929fce184c8012
content_type: application/pdf
creator: dernst
date_created: 2021-03-22T11:46:00Z
date_updated: 2021-09-16T22:30:03Z
embargo: 2021-09-15
file_id: '9276'
file_name: 2021_NatureChem_Petit_acceptedVersion.pdf
file_size: 1811448
relation: main_file
file_date_updated: 2021-09-16T22:30:03Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
issue: '5'
keyword:
- General Chemistry
- General Chemical Engineering
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 465-471
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanism of mediated alkali peroxide oxidation and triplet versus singlet
oxygen formation
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 13
year: '2021'
...
---
_id: '9623'
abstract:
- lang: eng
text: "Cytoplasmic reorganizations are essential for morphogenesis. In large cells
like oocytes, these reorganizations become crucial in patterning the oocyte for
later stages of embryonic development. Ascidians oocytes reorganize their cytoplasm
(ooplasm) in a spectacular manner. Ooplasmic reorganization is initiated at fertilization
with the contraction of the actomyosin cortex along the animal-vegetal axis of
the oocyte, driving the accumulation of cortical endoplasmic reticulum (cER),
maternal mRNAs associated to it and a mitochondria-rich subcortical layer – the
myoplasm – in a region of the vegetal pole termed contraction pole (CP). Here
we have used the species Phallusia mammillata to investigate the changes in cell
shape that accompany these reorganizations and the mechanochemical mechanisms
underlining CP formation.\r\nWe report that the length of the animal-vegetal (AV)
axis oscillates upon fertilization: it first undergoes a cycle of fast elongation-lengthening
followed by a slow expansion of mainly the vegetal pole (VP) of the cell. We show
that the fast oscillation corresponds to a dynamic polarization of the actin cortex
as a result of a fertilization-induced increase in cortical tension in the oocyte
that triggers a rupture of the cortex at the animal pole and the establishment
of vegetal-directed cortical flows. These flows are responsible for the vegetal
accumulation of actin causing the VP to flatten. \r\nWe find that the slow expansion
of the VP, leading to CP formation, correlates with a relaxation of the vegetal
cortex and that the myoplasm plays a role in the expansion. We show that the myoplasm
is a solid-like layer that buckles under compression forces arising from the contracting
actin cortex at the VP. Straightening of the myoplasm when actin flows stops,
facilitates the expansion of the VP and the CP. Altogether, our results present
a previously unrecognized role for the myoplasm in ascidian ooplasmic segregation.
\r\n"
acknowledged_ssus:
- _id: Bio
- _id: EM-Fac
- _id: NanoFab
- _id: M-Shop
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Silvia
full_name: Caballero Mancebo, Silvia
id: 2F1E1758-F248-11E8-B48F-1D18A9856A87
last_name: Caballero Mancebo
orcid: 0000-0002-5223-3346
citation:
ama: Caballero Mancebo S. Fertilization-induced deformations are controlled by the
actin cortex and a mitochondria-rich subcortical layer in ascidian oocytes. 2021.
doi:10.15479/at:ista:9623
apa: Caballero Mancebo, S. (2021). Fertilization-induced deformations are controlled
by the actin cortex and a mitochondria-rich subcortical layer in ascidian oocytes.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:9623
chicago: Caballero Mancebo, Silvia. “Fertilization-Induced Deformations Are Controlled
by the Actin Cortex and a Mitochondria-Rich Subcortical Layer in Ascidian Oocytes.”
Institute of Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:9623.
ieee: S. Caballero Mancebo, “Fertilization-induced deformations are controlled by
the actin cortex and a mitochondria-rich subcortical layer in ascidian oocytes,”
Institute of Science and Technology Austria, 2021.
ista: Caballero Mancebo S. 2021. Fertilization-induced deformations are controlled
by the actin cortex and a mitochondria-rich subcortical layer in ascidian oocytes.
Institute of Science and Technology Austria.
mla: Caballero Mancebo, Silvia. Fertilization-Induced Deformations Are Controlled
by the Actin Cortex and a Mitochondria-Rich Subcortical Layer in Ascidian Oocytes.
Institute of Science and Technology Austria, 2021, doi:10.15479/at:ista:9623.
short: S. Caballero Mancebo, Fertilization-Induced Deformations Are Controlled by
the Actin Cortex and a Mitochondria-Rich Subcortical Layer in Ascidian Oocytes,
Institute of Science and Technology Austria, 2021.
date_created: 2021-07-01T14:50:17Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2023-09-07T13:33:27Z
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: CaHe
doi: 10.15479/at:ista:9623
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date_created: 2021-07-01T14:48:54Z
date_updated: 2022-07-02T22:30:06Z
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file_name: PhDThesis_SCM.docx
file_size: 131946790
relation: source_file
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creator: scaballe
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date_updated: 2022-07-02T22:30:06Z
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has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '111'
publication_identifier:
isbn:
- 978-3-99078-012-1
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9750'
relation: part_of_dissertation
status: public
- id: '9006'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
title: Fertilization-induced deformations are controlled by the actin cortex and a
mitochondria-rich subcortical layer in ascidian oocytes
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '9006'
abstract:
- lang: eng
text: Cytoplasm is a gel-like crowded environment composed of various macromolecules,
organelles, cytoskeletal networks, and cytosol. The structure of the cytoplasm
is highly organized and heterogeneous due to the crowding of its constituents
and their effective compartmentalization. In such an environment, the diffusive
dynamics of the molecules are restricted, an effect that is further amplified
by clustering and anchoring of molecules. Despite the crowded nature of the cytoplasm
at the microscopic scale, large-scale reorganization of the cytoplasm is essential
for important cellular functions, such as cell division and polarization. How
such mesoscale reorganization of the cytoplasm is achieved, especially for large
cells such as oocytes or syncytial tissues that can span hundreds of micrometers
in size, is only beginning to be understood. In this review, we will discuss recent
advances in elucidating the molecular, cellular, and biophysical mechanisms by
which the cytoskeleton drives cytoplasmic reorganization across different scales,
structures, and species.
acknowledgement: We would like to thank Justine Renno for illustrations and Edouard
Hannezo and members of the Heisenberg group for their comments on previous versions
of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Shayan
full_name: Shamipour, Shayan
id: 40B34FE2-F248-11E8-B48F-1D18A9856A87
last_name: Shamipour
- first_name: Silvia
full_name: Caballero Mancebo, Silvia
id: 2F1E1758-F248-11E8-B48F-1D18A9856A87
last_name: Caballero Mancebo
orcid: 0000-0002-5223-3346
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Shamipour S, Caballero Mancebo S, Heisenberg C-PJ. Cytoplasm’s got moves. Developmental
Cell. 2021;56(2):P213-226. doi:10.1016/j.devcel.2020.12.002
apa: Shamipour, S., Caballero Mancebo, S., & Heisenberg, C.-P. J. (2021). Cytoplasm’s
got moves. Developmental Cell. Elsevier. https://doi.org/10.1016/j.devcel.2020.12.002
chicago: Shamipour, Shayan, Silvia Caballero Mancebo, and Carl-Philipp J Heisenberg.
“Cytoplasm’s Got Moves.” Developmental Cell. Elsevier, 2021. https://doi.org/10.1016/j.devcel.2020.12.002.
ieee: S. Shamipour, S. Caballero Mancebo, and C.-P. J. Heisenberg, “Cytoplasm’s
got moves,” Developmental Cell, vol. 56, no. 2. Elsevier, pp. P213-226,
2021.
ista: Shamipour S, Caballero Mancebo S, Heisenberg C-PJ. 2021. Cytoplasm’s got moves.
Developmental Cell. 56(2), P213-226.
mla: Shamipour, Shayan, et al. “Cytoplasm’s Got Moves.” Developmental Cell,
vol. 56, no. 2, Elsevier, 2021, pp. P213-226, doi:10.1016/j.devcel.2020.12.002.
short: S. Shamipour, S. Caballero Mancebo, C.-P.J. Heisenberg, Developmental Cell
56 (2021) P213-226.
date_created: 2021-01-17T23:01:10Z
date_published: 2021-01-25T00:00:00Z
date_updated: 2024-03-27T23:30:18Z
day: '25'
department:
- _id: CaHe
doi: 10.1016/j.devcel.2020.12.002
external_id:
isi:
- '000613273900009'
pmid:
- '33321104'
intvolume: ' 56'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.devcel.2020.12.002
month: '01'
oa: 1
oa_version: Published Version
page: P213-226
pmid: 1
publication: Developmental Cell
publication_identifier:
eissn:
- '18781551'
issn:
- '15345807'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '9623'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Cytoplasm's got moves
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 56
year: '2021'
...
---
_id: '9429'
abstract:
- lang: eng
text: De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3
lead to autism spectrum disorder (ASD). In mouse, constitutive haploinsufficiency
leads to motor coordination deficits as well as ASD-relevant social and cognitive
impairments. However, induction of Cul3 haploinsufficiency later in life does
not lead to ASD-relevant behaviors, pointing to an important role of Cul3 during
a critical developmental window. Here we show that Cul3 is essential to regulate
neuronal migration and, therefore, constitutive Cul3 heterozygous mutant mice
display cortical lamination abnormalities. At the molecular level, we found that
Cul3 controls neuronal migration by tightly regulating the amount of Plastin3
(Pls3), a previously unrecognized player of neural migration. Furthermore, we
found that Pls3 cell-autonomously regulates cell migration by regulating actin
cytoskeleton organization, and its levels are inversely proportional to neural
migration speed. Finally, we provide evidence that cellular phenotypes associated
with autism-linked gene haploinsufficiency can be rescued by transcriptional activation
of the intact allele in vitro, offering a proof of concept for a potential therapeutic
approach for ASDs.
acknowledged_ssus:
- _id: PreCl
acknowledgement: We thank A. Coll Manzano, F. Freeman, M. Ladron de Guevara, and A.
Ç. Yahya for technical assistance, S. Deixler, A. Lepold, and A. Schlerka for the
management of our animal colony, as well as M. Schunn and the Preclinical Facility
team for technical assistance. We thank K. Heesom and her team at the University
of Bristol Proteomics Facility for the proteomics sample preparation, data generation,
and analysis support. We thank Y. B. Simon for kindly providing the plasmid for
lentiviral labeling. Further, we thank M. Sixt for his advice regarding cell migration
and the fruitful discussions. This work was supported by the ISTPlus postdoctoral
fellowship (Grant Agreement No. 754411) to B.B., by the European Union’s Horizon
2020 research and innovation program (ERC) grant 715508 (REVERSEAUTISM), and by
the Austrian Science Fund (FWF) to G.N. (DK W1232-B24 and SFB F7807-B) and to J.G.D
(I3600-B27).
article_number: '3058'
article_processing_charge: No
article_type: original
author:
- first_name: Jasmin
full_name: Morandell, Jasmin
id: 4739D480-F248-11E8-B48F-1D18A9856A87
last_name: Morandell
- first_name: Lena A
full_name: Schwarz, Lena A
id: 29A8453C-F248-11E8-B48F-1D18A9856A87
last_name: Schwarz
- first_name: Bernadette
full_name: Basilico, Bernadette
id: 36035796-5ACA-11E9-A75E-7AF2E5697425
last_name: Basilico
orcid: 0000-0003-1843-3173
- first_name: Saren
full_name: Tasciyan, Saren
id: 4323B49C-F248-11E8-B48F-1D18A9856A87
last_name: Tasciyan
orcid: 0000-0003-1671-393X
- first_name: Georgi A
full_name: Dimchev, Georgi A
id: 38C393BE-F248-11E8-B48F-1D18A9856A87
last_name: Dimchev
orcid: 0000-0001-8370-6161
- first_name: Armel
full_name: Nicolas, Armel
id: 2A103192-F248-11E8-B48F-1D18A9856A87
last_name: Nicolas
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Caroline
full_name: Kreuzinger, Caroline
id: 382077BA-F248-11E8-B48F-1D18A9856A87
last_name: Kreuzinger
- first_name: Christoph
full_name: Dotter, Christoph
id: 4C66542E-F248-11E8-B48F-1D18A9856A87
last_name: Dotter
orcid: 0000-0002-9033-9096
- first_name: Lisa
full_name: Knaus, Lisa
id: 3B2ABCF4-F248-11E8-B48F-1D18A9856A87
last_name: Knaus
- first_name: Zoe
full_name: Dobler, Zoe
id: D23090A2-9057-11EA-883A-A8396FC7A38F
last_name: Dobler
- first_name: Emanuele
full_name: Cacci, Emanuele
last_name: Cacci
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Morandell J, Schwarz LA, Basilico B, et al. Cul3 regulates cytoskeleton protein
homeostasis and cell migration during a critical window of brain development.
Nature Communications. 2021;12(1). doi:10.1038/s41467-021-23123-x
apa: Morandell, J., Schwarz, L. A., Basilico, B., Tasciyan, S., Dimchev, G. A.,
Nicolas, A., … Novarino, G. (2021). Cul3 regulates cytoskeleton protein homeostasis
and cell migration during a critical window of brain development. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-021-23123-x
chicago: Morandell, Jasmin, Lena A Schwarz, Bernadette Basilico, Saren Tasciyan,
Georgi A Dimchev, Armel Nicolas, Christoph M Sommer, et al. “Cul3 Regulates Cytoskeleton
Protein Homeostasis and Cell Migration during a Critical Window of Brain Development.”
Nature Communications. Springer Nature, 2021. https://doi.org/10.1038/s41467-021-23123-x.
ieee: J. Morandell et al., “Cul3 regulates cytoskeleton protein homeostasis
and cell migration during a critical window of brain development,” Nature Communications,
vol. 12, no. 1. Springer Nature, 2021.
ista: Morandell J, Schwarz LA, Basilico B, Tasciyan S, Dimchev GA, Nicolas A, Sommer
CM, Kreuzinger C, Dotter C, Knaus L, Dobler Z, Cacci E, Schur FK, Danzl JG, Novarino
G. 2021. Cul3 regulates cytoskeleton protein homeostasis and cell migration during
a critical window of brain development. Nature Communications. 12(1), 3058.
mla: Morandell, Jasmin, et al. “Cul3 Regulates Cytoskeleton Protein Homeostasis
and Cell Migration during a Critical Window of Brain Development.” Nature Communications,
vol. 12, no. 1, 3058, Springer Nature, 2021, doi:10.1038/s41467-021-23123-x.
short: J. Morandell, L.A. Schwarz, B. Basilico, S. Tasciyan, G.A. Dimchev, A. Nicolas,
C.M. Sommer, C. Kreuzinger, C. Dotter, L. Knaus, Z. Dobler, E. Cacci, F.K. Schur,
J.G. Danzl, G. Novarino, Nature Communications 12 (2021).
date_created: 2021-05-28T11:49:46Z
date_published: 2021-05-24T00:00:00Z
date_updated: 2024-03-27T23:30:23Z
day: '24'
ddc:
- '572'
department:
- _id: GaNo
- _id: JoDa
- _id: FlSc
- _id: MiSi
- _id: LifeSc
- _id: Bio
doi: 10.1038/s41467-021-23123-x
ec_funded: 1
external_id:
isi:
- '000658769900010'
file:
- access_level: open_access
checksum: 337e0f7959c35ec959984cacdcb472ba
content_type: application/pdf
creator: kschuh
date_created: 2021-05-28T12:39:43Z
date_updated: 2021-05-28T12:39:43Z
file_id: '9430'
file_name: 2021_NatureCommunications_Morandell.pdf
file_size: 9358599
relation: main_file
success: 1
file_date_updated: 2021-05-28T12:39:43Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
issue: '1'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 25444568-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715508'
name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo
and in vitro Models
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
- _id: 05A0D778-7A3F-11EA-A408-12923DDC885E
grant_number: F07807
name: Neural stem cells in autism and epilepsy
- _id: 265CB4D0-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03600
name: Optical control of synaptic function via adhesion molecules
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: press_release
url: https://ist.ac.at/en/news/defective-gene-slows-down-brain-cells/
record:
- id: '7800'
relation: earlier_version
status: public
- id: '12401'
relation: dissertation_contains
status: public
status: public
title: Cul3 regulates cytoskeleton protein homeostasis and cell migration during a
critical window of brain development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2021'
...
---
_id: '10058'
abstract:
- lang: eng
text: 'Quantum information and computation has become a vast field paved with opportunities
for researchers and investors. As large multinational companies and international
funds are heavily investing in quantum technologies it is still a question which
platform is best suited for the task of realizing a scalable quantum processor.
In this work we investigate hole spins in Ge quantum wells. These hold great promise
as they possess several favorable properties: a small effective mass, a strong
spin-orbit coupling, long relaxation time and an inherent immunity to hyperfine
noise. All these characteristics helped Ge hole spin qubits to evolve from a single
qubit to a fully entangled four qubit processor in only 3 years. Here, we investigated
a qubit approach leveraging the large out-of-plane g-factors of heavy hole states
in Ge quantum dots. We found this qubit to be reproducibly operable at extremely
low magnetic field and at large speeds while maintaining coherence. This was possible
because large differences of g-factors in adjacent dots can be achieved in the
out-of-plane direction. In the in-plane direction the small g-factors, on the
other hand, can be altered very effectively by the confinement potentials. Here,
we found that this can even lead to a sign change of the g-factors. The resulting
g-factor difference alters the dynamics of the system drastically and produces
effects typically attributed to a spin-orbit induced spin-flip term. The investigations
carried out in this thesis give further insights into the possibilities of holes
in Ge and reveal new physical properties that need to be considered when designing
future spin qubit experiments.'
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
acknowledgement: The author gratefully acknowledges support by the Austrian Science
Fund (FWF), grants No P30207, and the Nomis foundation.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Daniel
full_name: Jirovec, Daniel
id: 4C473F58-F248-11E8-B48F-1D18A9856A87
last_name: Jirovec
orcid: 0000-0002-7197-4801
citation:
ama: Jirovec D. Singlet-Triplet qubits and spin-orbit interaction in 2-dimensional
Ge hole gases. 2021. doi:10.15479/at:ista:10058
apa: Jirovec, D. (2021). Singlet-Triplet qubits and spin-orbit interaction in
2-dimensional Ge hole gases. Institute of Science and Technology Austria.
https://doi.org/10.15479/at:ista:10058
chicago: Jirovec, Daniel. “Singlet-Triplet Qubits and Spin-Orbit Interaction in
2-Dimensional Ge Hole Gases.” Institute of Science and Technology Austria, 2021.
https://doi.org/10.15479/at:ista:10058.
ieee: D. Jirovec, “Singlet-Triplet qubits and spin-orbit interaction in 2-dimensional
Ge hole gases,” Institute of Science and Technology Austria, 2021.
ista: Jirovec D. 2021. Singlet-Triplet qubits and spin-orbit interaction in 2-dimensional
Ge hole gases. Institute of Science and Technology Austria.
mla: Jirovec, Daniel. Singlet-Triplet Qubits and Spin-Orbit Interaction in 2-Dimensional
Ge Hole Gases. Institute of Science and Technology Austria, 2021, doi:10.15479/at:ista:10058.
short: D. Jirovec, Singlet-Triplet Qubits and Spin-Orbit Interaction in 2-Dimensional
Ge Hole Gases, Institute of Science and Technology Austria, 2021.
date_created: 2021-09-30T07:53:49Z
date_published: 2021-10-05T00:00:00Z
date_updated: 2023-09-08T11:41:08Z
day: '05'
ddc:
- '621'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: GeKa
doi: 10.15479/at:ista:10058
file:
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checksum: ad6bcb24083ed7c02baaf1885c9ea3d5
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date_updated: 2022-12-20T23:30:07Z
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file_name: PHD_Thesis_Jirovec_Source.zip
file_size: 32397600
relation: source_file
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creator: djirovec
date_created: 2021-10-05T07:56:49Z
date_updated: 2022-12-20T23:30:07Z
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file_size: 26910829
relation: main_file
file_date_updated: 2022-12-20T23:30:07Z
has_accepted_license: '1'
keyword:
- qubits
- quantum computing
- holes
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: '151'
project:
- _id: 2641CE5E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P30207
name: Hole spin orbit qubits in Ge quantum wells
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8831'
relation: part_of_dissertation
status: public
- id: '10065'
relation: part_of_dissertation
status: public
- id: '10066'
relation: part_of_dissertation
status: public
- id: '8909'
relation: part_of_dissertation
status: public
- id: '5816'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
title: Singlet-Triplet qubits and spin-orbit interaction in 2-dimensional Ge hole
gases
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '8909'
abstract:
- lang: eng
text: Spin qubits are considered to be among the most promising candidates for building
a quantum processor. Group IV hole spin qubits have moved into the focus of interest
due to the ease of operation and compatibility with Si technology. In addition,
Ge offers the option for monolithic superconductor-semiconductor integration.
Here we demonstrate a hole spin qubit operating at fields below 10 mT, the critical
field of Al, by exploiting the large out-of-plane hole g-factors in planar Ge
and by encoding the qubit into the singlet-triplet states of a double quantum
dot. We observe electrically controlled X and Z-rotations with tunable frequencies
exceeding 100 MHz and dephasing times of 1μs which we extend beyond 15μs with
echo techniques. These results show that Ge hole singlet triplet qubits outperform
their electronic Si and GaAs based counterparts in speed and coherence, respectively.
In addition, they are on par with Ge single spin qubits, but can be operated at
much lower fields underlining their potential for on chip integration with superconducting
technologies.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
acknowledgement: This research was supported by the Scientific Service Units of Institute
of Science and Technology (IST) Austria through resources provided by the Miba Machine
Shop and the nanofabrication facility, and was made possible with the support of
the NOMIS Foundation. This project has received funding from the European Union’s
Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant
agreements no. 844511 and no. 75441, and by the Austrian Science Fund FWF-P 30207
project. A.B. acknowledges support from the European Union Horizon 2020 FET project
microSPIRE, no. 766955. M. Botifoll and J.A. acknowledge funding from Generalitat
de Catalunya 2017 SGR 327. The Catalan Institute of Nanoscience and Nanotechnology
(ICN2) is supported by the Severo Ochoa programme from the Spanish Ministery of
Economy (MINECO) (grant no. SEV-2017-0706) and is funded by the Catalonian Research
Centre (CERCA) Programme, Generalitat de Catalunya. Part of the present work has
been performed within the framework of the Universitat Autónoma de Barcelona Materials
Science PhD programme. Part of the HAADF scanning transmission electron microscopy
was conducted in the Laboratorio de Microscopias Avanzadas at Instituto de Nanociencia
de Aragon, Universidad de Zaragoza. ICN2 acknowledge support from the Spanish Superior
Council of Scientific Research (CSIC) Research Platform on Quantum Technologies
PTI-001. M.B. acknowledges funding from the Catalan Agency for Management of University
and Research Grants (AGAUR) Generalitat de Catalunya formation of investigators
(FI) PhD grant.
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
full_name: Jirovec, Daniel
id: 4C473F58-F248-11E8-B48F-1D18A9856A87
last_name: Jirovec
orcid: 0000-0002-7197-4801
- first_name: Andrea C
full_name: Hofmann, Andrea C
id: 340F461A-F248-11E8-B48F-1D18A9856A87
last_name: Hofmann
- first_name: Andrea
full_name: Ballabio, Andrea
last_name: Ballabio
- first_name: Philipp M.
full_name: Mutter, Philipp M.
last_name: Mutter
- first_name: Giulio
full_name: Tavani, Giulio
last_name: Tavani
- first_name: Marc
full_name: Botifoll, Marc
last_name: Botifoll
- first_name: Alessandro
full_name: Crippa, Alessandro
id: 1F2B21A2-F6E7-11E9-9B82-F7DBE5697425
last_name: Crippa
orcid: 0000-0002-2968-611X
- first_name: Josip
full_name: Kukucka, Josip
id: 3F5D8856-F248-11E8-B48F-1D18A9856A87
last_name: Kukucka
- first_name: Oliver
full_name: Sagi, Oliver
id: 71616374-A8E9-11E9-A7CA-09ECE5697425
last_name: Sagi
- first_name: Frederico
full_name: Martins, Frederico
id: 38F80F9A-1CB8-11EA-BC76-B49B3DDC885E
last_name: Martins
orcid: 0000-0003-2668-2401
- first_name: Jaime
full_name: Saez Mollejo, Jaime
id: e0390f72-f6e0-11ea-865d-862393336714
last_name: Saez Mollejo
- first_name: Ivan
full_name: Prieto Gonzalez, Ivan
id: 2A307FE2-F248-11E8-B48F-1D18A9856A87
last_name: Prieto Gonzalez
orcid: 0000-0002-7370-5357
- first_name: Maksim
full_name: Borovkov, Maksim
id: 2ac7a0a2-3562-11eb-9256-fbd18ea55087
last_name: Borovkov
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Daniel
full_name: Chrastina, Daniel
last_name: Chrastina
- first_name: Giovanni
full_name: Isella, Giovanni
last_name: Isella
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: Jirovec D, Hofmann AC, Ballabio A, et al. A singlet triplet hole spin qubit
in planar Ge. Nature Materials. 2021;20(8):1106–1112. doi:10.1038/s41563-021-01022-2
apa: Jirovec, D., Hofmann, A. C., Ballabio, A., Mutter, P. M., Tavani, G., Botifoll,
M., … Katsaros, G. (2021). A singlet triplet hole spin qubit in planar Ge. Nature
Materials. Springer Nature. https://doi.org/10.1038/s41563-021-01022-2
chicago: Jirovec, Daniel, Andrea C Hofmann, Andrea Ballabio, Philipp M. Mutter,
Giulio Tavani, Marc Botifoll, Alessandro Crippa, et al. “A Singlet Triplet Hole
Spin Qubit in Planar Ge.” Nature Materials. Springer Nature, 2021. https://doi.org/10.1038/s41563-021-01022-2.
ieee: D. Jirovec et al., “A singlet triplet hole spin qubit in planar Ge,”
Nature Materials, vol. 20, no. 8. Springer Nature, pp. 1106–1112, 2021.
ista: Jirovec D, Hofmann AC, Ballabio A, Mutter PM, Tavani G, Botifoll M, Crippa
A, Kukucka J, Sagi O, Martins F, Saez Mollejo J, Prieto Gonzalez I, Borovkov M,
Arbiol J, Chrastina D, Isella G, Katsaros G. 2021. A singlet triplet hole spin
qubit in planar Ge. Nature Materials. 20(8), 1106–1112.
mla: Jirovec, Daniel, et al. “A Singlet Triplet Hole Spin Qubit in Planar Ge.” Nature
Materials, vol. 20, no. 8, Springer Nature, 2021, pp. 1106–1112, doi:10.1038/s41563-021-01022-2.
short: D. Jirovec, A.C. Hofmann, A. Ballabio, P.M. Mutter, G. Tavani, M. Botifoll,
A. Crippa, J. Kukucka, O. Sagi, F. Martins, J. Saez Mollejo, I. Prieto Gonzalez,
M. Borovkov, J. Arbiol, D. Chrastina, G. Isella, G. Katsaros, Nature Materials
20 (2021) 1106–1112.
date_created: 2020-12-02T10:50:47Z
date_published: 2021-08-01T00:00:00Z
date_updated: 2024-03-27T23:30:26Z
day: '01'
department:
- _id: GeKa
- _id: NanoFab
- _id: GradSch
doi: 10.1038/s41563-021-01022-2
ec_funded: 1
external_id:
arxiv:
- '2011.13755'
isi:
- '000657596400001'
intvolume: ' 20'
isi: 1
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2011.13755
month: '08'
oa: 1
oa_version: Preprint
page: 1106–1112
project:
- _id: 26A151DA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '844511'
name: Majorana bound states in Ge/SiGe heterostructures
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 2641CE5E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P30207
name: Hole spin orbit qubits in Ge quantum wells
- _id: 262116AA-B435-11E9-9278-68D0E5697425
name: Hybrid Semiconductor - Superconductor Quantum Devices
publication: Nature Materials
publication_identifier:
eissn:
- 1476-4660
issn:
- 1476-1122
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/quantum-computing-with-holes/
record:
- id: '9323'
relation: research_data
status: public
- id: '10058'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: A singlet triplet hole spin qubit in planar Ge
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 20
year: '2021'
...
---
_id: '9397'
abstract:
- lang: eng
text: Accumulation of interstitial fluid (IF) between embryonic cells is a common
phenomenon in vertebrate embryogenesis. Unlike other model systems, where these
accumulations coalesce into a large central cavity – the blastocoel, in zebrafish,
IF is more uniformly distributed between the deep cells (DC) before the onset
of gastrulation. This is likely due to the presence of a large extraembryonic
structure – the yolk cell (YC) at the position where the blastocoel typically
forms in other model organisms. IF has long been speculated to play a role in
tissue morphogenesis during embryogenesis, but direct evidence supporting such
function is still sparse. Here we show that the relocalization of IF to the interface
between the YC and DC/epiblast is critical for axial mesendoderm (ME) cell protrusion
formation and migration along this interface, a key process in embryonic axis
formation. We further demonstrate that axial ME cell migration and IF relocalization
engage in a positive feedback loop, where axial ME migration triggers IF accumulation
ahead of the advancing axial ME tissue by mechanically compressing the overlying
epiblast cell layer. Upon compression, locally induced flow relocalizes the IF
through the porous epiblast tissue resulting in an IF accumulation ahead of the
leading axial ME. This IF accumulation, in turn, promotes cell protrusion formation
and migration of the leading axial ME cells, thereby facilitating axial ME extension.
Our findings reveal a central role of dynamic IF relocalization in orchestrating
germ layer morphogenesis during gastrulation.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Karla
full_name: Huljev, Karla
id: 44C6F6A6-F248-11E8-B48F-1D18A9856A87
last_name: Huljev
citation:
ama: Huljev K. Coordinated spatiotemporal reorganization of interstitial fluid is
required for axial mesendoderm migration in zebrafish gastrulation. 2021. doi:10.15479/at:ista:9397
apa: Huljev, K. (2021). Coordinated spatiotemporal reorganization of interstitial
fluid is required for axial mesendoderm migration in zebrafish gastrulation.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:9397
chicago: Huljev, Karla. “Coordinated Spatiotemporal Reorganization of Interstitial
Fluid Is Required for Axial Mesendoderm Migration in Zebrafish Gastrulation.”
Institute of Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:9397.
ieee: K. Huljev, “Coordinated spatiotemporal reorganization of interstitial fluid
is required for axial mesendoderm migration in zebrafish gastrulation,” Institute
of Science and Technology Austria, 2021.
ista: Huljev K. 2021. Coordinated spatiotemporal reorganization of interstitial
fluid is required for axial mesendoderm migration in zebrafish gastrulation. Institute
of Science and Technology Austria.
mla: Huljev, Karla. Coordinated Spatiotemporal Reorganization of Interstitial
Fluid Is Required for Axial Mesendoderm Migration in Zebrafish Gastrulation.
Institute of Science and Technology Austria, 2021, doi:10.15479/at:ista:9397.
short: K. Huljev, Coordinated Spatiotemporal Reorganization of Interstitial Fluid
Is Required for Axial Mesendoderm Migration in Zebrafish Gastrulation, Institute
of Science and Technology Austria, 2021.
date_created: 2021-05-17T12:31:30Z
date_published: 2021-05-18T00:00:00Z
date_updated: 2023-09-07T13:32:32Z
day: '18'
ddc:
- '571'
degree_awarded: PhD
department:
- _id: CaHe
- _id: GradSch
doi: 10.15479/at:ista:9397
file:
- access_level: closed
checksum: 7f98532f5324a0b2f3fa8de2967baa19
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: khuljev
date_created: 2021-05-17T12:29:12Z
date_updated: 2022-05-21T22:30:04Z
embargo_to: open_access
file_id: '9398'
file_name: KHuljev_Thesis_corrections.docx
file_size: 47799741
relation: source_file
- access_level: open_access
checksum: bf512f8a1e572a543778fc4b227c01ba
content_type: application/pdf
creator: khuljev
date_created: 2021-05-18T14:50:28Z
date_updated: 2022-05-21T22:30:04Z
embargo: 2022-05-20
file_id: '9401'
file_name: new_KHuljev_Thesis_corrections.pdf
file_size: 16542131
relation: main_file
file_date_updated: 2022-05-21T22:30:04Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '101'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
title: Coordinated spatiotemporal reorganization of interstitial fluid is required
for axial mesendoderm migration in zebrafish gastrulation
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '10066'
abstract:
- lang: eng
text: The potential of Si and SiGe-based devices for the scaling of quantum circuits
is tainted by device variability. Each device needs to be tuned to operation conditions.
We give a key step towards tackling this variability with an algorithm that, without
modification, is capable of tuning a 4-gate Si FinFET, a 5-gate GeSi nanowire
and a 7-gate SiGe heterostructure double quantum dot device from scratch. We achieve
tuning times of 30, 10, and 92 minutes, respectively. The algorithm also provides
insight into the parameter space landscape for each of these devices. These results
show that overarching solutions for the tuning of quantum devices are enabled
by machine learning.
acknowledged_ssus:
- _id: NanoFab
acknowledgement: "We acknowledge Ang Li, Erik P. A. M. Bakkers (University of Eindhoven)
for the fabrication of the Ge/Si nanowire. This work was supported by the Royal
Society, the EPSRC National Quantum Technology Hub in Networked Quantum Information
Technology (EP/M013243/1), Quantum Technology Capital (EP/N014995/1), EPSRC Platform
Grant\r\n(EP/R029229/1), the European Research Council (Grant agreement 948932),
the Swiss Nanoscience Institute, the\r\nNCCR SPIN, the EU H2020 European Microkelvin
Platform EMP grant No. 824109, the Scientific Service Units\r\nof IST Austria through
resources provided by the nanofabrication facility and, the FWF-P30207 project.
This publication was also made possible through support from Templeton World Charity
Foundation and John Templeton Foundation. The opinions expressed in this publication
are those of the authors and do not necessarily reflect the views of the Templeton
Foundations."
article_number: '2107.12975'
article_processing_charge: No
author:
- first_name: B.
full_name: Severin, B.
last_name: Severin
- first_name: D. T.
full_name: Lennon, D. T.
last_name: Lennon
- first_name: L. C.
full_name: Camenzind, L. C.
last_name: Camenzind
- first_name: F.
full_name: Vigneau, F.
last_name: Vigneau
- first_name: F.
full_name: Fedele, F.
last_name: Fedele
- first_name: Daniel
full_name: Jirovec, Daniel
id: 4C473F58-F248-11E8-B48F-1D18A9856A87
last_name: Jirovec
orcid: 0000-0002-7197-4801
- first_name: A.
full_name: Ballabio, A.
last_name: Ballabio
- first_name: D.
full_name: Chrastina, D.
last_name: Chrastina
- first_name: G.
full_name: Isella, G.
last_name: Isella
- first_name: M. de
full_name: Kruijf, M. de
last_name: Kruijf
- first_name: M. J.
full_name: Carballido, M. J.
last_name: Carballido
- first_name: S.
full_name: Svab, S.
last_name: Svab
- first_name: A. V.
full_name: Kuhlmann, A. V.
last_name: Kuhlmann
- first_name: F. R.
full_name: Braakman, F. R.
last_name: Braakman
- first_name: S.
full_name: Geyer, S.
last_name: Geyer
- first_name: F. N. M.
full_name: Froning, F. N. M.
last_name: Froning
- first_name: H.
full_name: Moon, H.
last_name: Moon
- first_name: M. A.
full_name: Osborne, M. A.
last_name: Osborne
- first_name: D.
full_name: Sejdinovic, D.
last_name: Sejdinovic
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
- first_name: D. M.
full_name: Zumbühl, D. M.
last_name: Zumbühl
- first_name: G. A. D.
full_name: Briggs, G. A. D.
last_name: Briggs
- first_name: N.
full_name: Ares, N.
last_name: Ares
citation:
ama: Severin B, Lennon DT, Camenzind LC, et al. Cross-architecture tuning of silicon
and SiGe-based quantum devices using machine learning. arXiv. doi:10.48550/arXiv.2107.12975
apa: Severin, B., Lennon, D. T., Camenzind, L. C., Vigneau, F., Fedele, F., Jirovec,
D., … Ares, N. (n.d.). Cross-architecture tuning of silicon and SiGe-based quantum
devices using machine learning. arXiv. https://doi.org/10.48550/arXiv.2107.12975
chicago: Severin, B., D. T. Lennon, L. C. Camenzind, F. Vigneau, F. Fedele, Daniel
Jirovec, A. Ballabio, et al. “Cross-Architecture Tuning of Silicon and SiGe-Based
Quantum Devices Using Machine Learning.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2107.12975.
ieee: B. Severin et al., “Cross-architecture tuning of silicon and SiGe-based
quantum devices using machine learning,” arXiv. .
ista: Severin B, Lennon DT, Camenzind LC, Vigneau F, Fedele F, Jirovec D, Ballabio
A, Chrastina D, Isella G, Kruijf M de, Carballido MJ, Svab S, Kuhlmann AV, Braakman
FR, Geyer S, Froning FNM, Moon H, Osborne MA, Sejdinovic D, Katsaros G, Zumbühl
DM, Briggs GAD, Ares N. Cross-architecture tuning of silicon and SiGe-based quantum
devices using machine learning. arXiv, 2107.12975.
mla: Severin, B., et al. “Cross-Architecture Tuning of Silicon and SiGe-Based Quantum
Devices Using Machine Learning.” ArXiv, 2107.12975, doi:10.48550/arXiv.2107.12975.
short: B. Severin, D.T. Lennon, L.C. Camenzind, F. Vigneau, F. Fedele, D. Jirovec,
A. Ballabio, D. Chrastina, G. Isella, M. de Kruijf, M.J. Carballido, S. Svab,
A.V. Kuhlmann, F.R. Braakman, S. Geyer, F.N.M. Froning, H. Moon, M.A. Osborne,
D. Sejdinovic, G. Katsaros, D.M. Zumbühl, G.A.D. Briggs, N. Ares, ArXiv (n.d.).
date_created: 2021-10-01T12:40:22Z
date_published: 2021-07-27T00:00:00Z
date_updated: 2024-03-27T23:30:26Z
day: '27'
department:
- _id: GeKa
doi: 10.48550/arXiv.2107.12975
external_id:
arxiv:
- '2107.12975'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2107.12975
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 2641CE5E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P30207
name: Hole spin orbit qubits in Ge quantum wells
publication: arXiv
publication_status: submitted
related_material:
record:
- id: '10058'
relation: dissertation_contains
status: public
status: public
title: Cross-architecture tuning of silicon and SiGe-based quantum devices using machine
learning
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '9437'
abstract:
- lang: eng
text: The synaptic connection from medial habenula (MHb) to interpeduncular nucleus
(IPN) is critical for emotion-related behaviors and uniquely expresses R-type
Ca2+ channels (Cav2.3) and auxiliary GABAB receptor (GBR) subunits, the K+-channel
tetramerization domain-containing proteins (KCTDs). Activation of GBRs facilitates
or inhibits transmitter release from MHb terminals depending on the IPN subnucleus,
but the role of KCTDs is unknown. We therefore examined the localization and function
of Cav2.3, GBRs, and KCTDs in this pathway in mice. We show in heterologous cells
that KCTD8 and KCTD12b directly bind to Cav2.3 and that KCTD8 potentiates Cav2.3
currents in the absence of GBRs. In the rostral IPN, KCTD8, KCTD12b, and Cav2.3
co-localize at the presynaptic active zone. Genetic deletion indicated a bidirectional
modulation of Cav2.3-mediated release by these KCTDs with a compensatory increase
of KCTD8 in the active zone in KCTD12b-deficient mice. The interaction of Cav2.3
with KCTDs therefore scales synaptic strength independent of GBR activation.
acknowledgement: We are grateful to Akari Hagiwara and Toshihisa Ohtsuka for CAST
antibody, and Masahiko Watanabe for neurexin antibody. We thank David Adams for
kindly providing the stable Cav2.3 cell line. Cav2.3 KO mice were kindly provided
by Tsutomu Tanabe. This project has received funding from the European Research
Council (ERC) and European Commission (EC), under the European Union’s Horizon 2020
research and innovation programme (ERC grant agreement no. 694539 to Ryuichi Shigemoto,
no. 692692 to Peter Jonas, and the Marie Skłodowska-Curie grant agreement no. 665385
to Cihan Önal), the Swiss National Science Foundation Grant 31003A-172881 to Bernhard
Bettler and Deutsche Forschungsgemeinschaft (For 2143) and BIOSS-2 to Akos Kulik.
article_number: e68274
article_processing_charge: No
article_type: original
author:
- first_name: Pradeep
full_name: Bhandari, Pradeep
id: 45EDD1BC-F248-11E8-B48F-1D18A9856A87
last_name: Bhandari
orcid: 0000-0003-0863-4481
- first_name: David H
full_name: Vandael, David H
id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87
last_name: Vandael
orcid: 0000-0001-7577-1676
- first_name: Diego
full_name: Fernández-Fernández, Diego
last_name: Fernández-Fernández
- first_name: Thorsten
full_name: Fritzius, Thorsten
last_name: Fritzius
- first_name: David
full_name: Kleindienst, David
id: 42E121A4-F248-11E8-B48F-1D18A9856A87
last_name: Kleindienst
- first_name: Hüseyin C
full_name: Önal, Hüseyin C
id: 4659D740-F248-11E8-B48F-1D18A9856A87
last_name: Önal
orcid: 0000-0002-2771-2011
- first_name: Jacqueline-Claire
full_name: Montanaro-Punzengruber, Jacqueline-Claire
id: 3786AB44-F248-11E8-B48F-1D18A9856A87
last_name: Montanaro-Punzengruber
- first_name: Martin
full_name: Gassmann, Martin
last_name: Gassmann
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Akos
full_name: Kulik, Akos
last_name: Kulik
- first_name: Bernhard
full_name: Bettler, Bernhard
last_name: Bettler
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Peter
full_name: Koppensteiner, Peter
id: 3B8B25A8-F248-11E8-B48F-1D18A9856A87
last_name: Koppensteiner
orcid: 0000-0002-3509-1948
citation:
ama: Bhandari P, Vandael DH, Fernández-Fernández D, et al. GABAB receptor auxiliary
subunits modulate Cav2.3-mediated release from medial habenula terminals. eLife.
2021;10. doi:10.7554/ELIFE.68274
apa: Bhandari, P., Vandael, D. H., Fernández-Fernández, D., Fritzius, T., Kleindienst,
D., Önal, H. C., … Koppensteiner, P. (2021). GABAB receptor auxiliary subunits
modulate Cav2.3-mediated release from medial habenula terminals. ELife.
eLife Sciences Publications. https://doi.org/10.7554/ELIFE.68274
chicago: Bhandari, Pradeep, David H Vandael, Diego Fernández-Fernández, Thorsten
Fritzius, David Kleindienst, Hüseyin C Önal, Jacqueline-Claire Montanaro-Punzengruber,
et al. “GABAB Receptor Auxiliary Subunits Modulate Cav2.3-Mediated Release from
Medial Habenula Terminals.” ELife. eLife Sciences Publications, 2021. https://doi.org/10.7554/ELIFE.68274.
ieee: P. Bhandari et al., “GABAB receptor auxiliary subunits modulate Cav2.3-mediated
release from medial habenula terminals,” eLife, vol. 10. eLife Sciences
Publications, 2021.
ista: Bhandari P, Vandael DH, Fernández-Fernández D, Fritzius T, Kleindienst D,
Önal HC, Montanaro-Punzengruber J-C, Gassmann M, Jonas PM, Kulik A, Bettler B,
Shigemoto R, Koppensteiner P. 2021. GABAB receptor auxiliary subunits modulate
Cav2.3-mediated release from medial habenula terminals. eLife. 10, e68274.
mla: Bhandari, Pradeep, et al. “GABAB Receptor Auxiliary Subunits Modulate Cav2.3-Mediated
Release from Medial Habenula Terminals.” ELife, vol. 10, e68274, eLife
Sciences Publications, 2021, doi:10.7554/ELIFE.68274.
short: P. Bhandari, D.H. Vandael, D. Fernández-Fernández, T. Fritzius, D. Kleindienst,
H.C. Önal, J.-C. Montanaro-Punzengruber, M. Gassmann, P.M. Jonas, A. Kulik, B.
Bettler, R. Shigemoto, P. Koppensteiner, ELife 10 (2021).
date_created: 2021-05-30T22:01:23Z
date_published: 2021-04-29T00:00:00Z
date_updated: 2024-03-27T23:30:30Z
day: '29'
ddc:
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doi: 10.7554/ELIFE.68274
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call_identifier: H2020
grant_number: '694539'
name: 'In situ analysis of single channel subunit composition in neurons: physiological
implication in synaptic plasticity and behaviour'
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call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
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eissn:
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publisher: eLife Sciences Publications
quality_controlled: '1'
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url: https://doi.org/10.1101/2020.04.16.045112
record:
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relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial
habenula terminals
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
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volume: 10
year: '2021'
...
---
_id: '9562'
abstract:
- lang: eng
text: Left-right asymmetries can be considered a fundamental organizational principle
of the vertebrate central nervous system. The hippocampal CA3-CA1 pyramidal cell
synaptic connection shows an input-side dependent asymmetry where the hemispheric
location of the presynaptic CA3 neuron determines the synaptic properties. Left-input
synapses terminating on apical dendrites in stratum radiatum have a higher density
of NMDA receptor subunit GluN2B, a lower density of AMPA receptor subunit GluA1
and smaller areas with less often perforated PSDs. On the other hand, left-input
synapses terminating on basal dendrites in stratum oriens have lower GluN2B densities
than right-input ones. Apical and basal synapses further employ different signaling
pathways involved in LTP. SDS-digested freeze-fracture replica labeling can visualize
synaptic membrane proteins with high sensitivity and resolution, and has been
used to reveal the asymmetry at the electron microscopic level. However, it requires
time-consuming manual demarcation of the synaptic surface for quantitative measurements.
To facilitate the analysis of replica labeling, I first developed a software named
Darea, which utilizes deep-learning to automatize this demarcation. With Darea
I characterized the synaptic distribution of NMDA and AMPA receptors as well as
the voltage-gated Ca2+ channels in CA1 stratum radiatum and oriens. Second, I
explored the role of GluN2B and its carboxy-terminus in the establishment of input-side
dependent hippocampal asymmetry. In conditional knock-out mice lacking GluN2B
expression in CA1 and GluN2B-2A swap mice, where GluN2B carboxy-terminus was exchanged
to that of GluN2A, no significant asymmetries of GluN2B, GluA1 and PSD area were
detected. We further discovered a previously unknown functional asymmetry of GluN2A,
which was also lost in the swap mouse. These results demonstrate that GluN2B carboxy-terminus
plays a critical role in normal formation of input-side dependent asymmetry.
acknowledged_ssus:
- _id: EM-Fac
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: David
full_name: Kleindienst, David
id: 42E121A4-F248-11E8-B48F-1D18A9856A87
last_name: Kleindienst
citation:
ama: 'Kleindienst D. 2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor
subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning.
2021. doi:10.15479/at:ista:9562'
apa: 'Kleindienst, D. (2021). 2B or not 2B: Hippocampal asymmetries mediated
by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis
by Deep-Learning. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:9562'
chicago: 'Kleindienst, David. “2B or Not 2B: Hippocampal Asymmetries Mediated by
NMDA Receptor Subunit GluN2B C-Terminus and High-Throughput Image Analysis by
Deep-Learning.” Institute of Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:9562.'
ieee: 'D. Kleindienst, “2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor
subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning,”
Institute of Science and Technology Austria, 2021.'
ista: 'Kleindienst D. 2021. 2B or not 2B: Hippocampal asymmetries mediated by NMDA
receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning.
Institute of Science and Technology Austria.'
mla: 'Kleindienst, David. 2B or Not 2B: Hippocampal Asymmetries Mediated by NMDA
Receptor Subunit GluN2B C-Terminus and High-Throughput Image Analysis by Deep-Learning.
Institute of Science and Technology Austria, 2021, doi:10.15479/at:ista:9562.'
short: 'D. Kleindienst, 2B or Not 2B: Hippocampal Asymmetries Mediated by NMDA Receptor
Subunit GluN2B C-Terminus and High-Throughput Image Analysis by Deep-Learning,
Institute of Science and Technology Austria, 2021.'
date_created: 2021-06-17T14:10:47Z
date_published: 2021-06-01T00:00:00Z
date_updated: 2023-09-11T12:55:53Z
day: '01'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RySh
doi: 10.15479/at:ista:9562
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issn:
- 2663-337X
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publisher: Institute of Science and Technology Austria
related_material:
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status: public
status: public
supervisor:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
title: '2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B
C-terminus and high-throughput image analysis by Deep-Learning'
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '8934'
abstract:
- lang: eng
text: "In this thesis, we consider several of the most classical and fundamental
problems in static analysis and formal verification, including invariant generation,
reachability analysis, termination analysis of probabilistic programs, data-flow
analysis, quantitative analysis of Markov chains and Markov decision processes,
and the problem of data packing in cache management.\r\nWe use techniques from
parameterized complexity theory, polyhedral geometry, and real algebraic geometry
to significantly improve the state-of-the-art, in terms of both scalability and
completeness guarantees, for the mentioned problems. In some cases, our results
are the first theoretical improvements for the respective problems in two or three
decades."
acknowledgement: 'The research was partially supported by an IBM PhD fellowship, a
Facebook PhD fellowship, and DOC fellowship #24956 of the Austrian Academy of Sciences
(OeAW).'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Amir Kafshdar
full_name: Goharshady, Amir Kafshdar
id: 391365CE-F248-11E8-B48F-1D18A9856A87
last_name: Goharshady
orcid: 0000-0003-1702-6584
citation:
ama: Goharshady AK. Parameterized and algebro-geometric advances in static program
analysis. 2021. doi:10.15479/AT:ISTA:8934
apa: Goharshady, A. K. (2021). Parameterized and algebro-geometric advances in
static program analysis. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8934
chicago: Goharshady, Amir Kafshdar. “Parameterized and Algebro-Geometric Advances
in Static Program Analysis.” Institute of Science and Technology Austria, 2021.
https://doi.org/10.15479/AT:ISTA:8934.
ieee: A. K. Goharshady, “Parameterized and algebro-geometric advances in static
program analysis,” Institute of Science and Technology Austria, 2021.
ista: Goharshady AK. 2021. Parameterized and algebro-geometric advances in static
program analysis. Institute of Science and Technology Austria.
mla: Goharshady, Amir Kafshdar. Parameterized and Algebro-Geometric Advances
in Static Program Analysis. Institute of Science and Technology Austria, 2021,
doi:10.15479/AT:ISTA:8934.
short: A.K. Goharshady, Parameterized and Algebro-Geometric Advances in Static Program
Analysis, Institute of Science and Technology Austria, 2021.
date_created: 2020-12-10T12:17:07Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2023-09-22T10:03:21Z
day: '01'
ddc:
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degree_awarded: PhD
department:
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language:
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license: https://creativecommons.org/publicdomain/zero/1.0/
month: '01'
oa: 1
oa_version: Published Version
page: '278'
project:
- _id: 267066CE-B435-11E9-9278-68D0E5697425
name: Quantitative Analysis of Probablistic Systems with a focus on Crypto-currencies
- _id: 266EEEC0-B435-11E9-9278-68D0E5697425
name: Quantitative Game-theoretic Analysis of Blockchain Applications and Smart
Contracts
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
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- id: '6009'
relation: part_of_dissertation
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- id: '6340'
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status: public
- id: '949'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
title: Parameterized and algebro-geometric advances in static program analysis
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image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
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short: CC0 (1.0)
type: dissertation
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year: '2021'
...
---
_id: '10307'
abstract:
- lang: eng
text: Bacteria-host interactions represent a continuous trade-off between benefit
and risk. Thus, the host immune response is faced with a non-trivial problem –
accommodate beneficial commensals and remove harmful pathogens. This is especially
difficult as molecular patterns, such as lipopolysaccharide or specific surface
organelles such as pili, are conserved in both, commensal and pathogenic bacteria.
Type 1 pili, tightly regulated by phase variation, are considered an important
virulence factor of pathogenic bacteria as they facilitate invasion into host
cells. While invasion represents a de facto passive mechanism for pathogens to
escape the host immune response, we demonstrate a fundamental role of type 1 pili
as active modulators of the innate and adaptive immune response.
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
- _id: PreCl
- _id: EM-Fac
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
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full_name: Tomasek, Kathrin
id: 3AEC8556-F248-11E8-B48F-1D18A9856A87
last_name: Tomasek
orcid: 0000-0003-3768-877X
citation:
ama: Tomasek K. Pathogenic Escherichia coli hijack the host immune response. 2021.
doi:10.15479/at:ista:10307
apa: Tomasek, K. (2021). Pathogenic Escherichia coli hijack the host immune response.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:10307
chicago: Tomasek, Kathrin. “Pathogenic Escherichia Coli Hijack the Host Immune Response.”
Institute of Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:10307.
ieee: K. Tomasek, “Pathogenic Escherichia coli hijack the host immune response,”
Institute of Science and Technology Austria, 2021.
ista: Tomasek K. 2021. Pathogenic Escherichia coli hijack the host immune response.
Institute of Science and Technology Austria.
mla: Tomasek, Kathrin. Pathogenic Escherichia Coli Hijack the Host Immune Response.
Institute of Science and Technology Austria, 2021, doi:10.15479/at:ista:10307.
short: K. Tomasek, Pathogenic Escherichia Coli Hijack the Host Immune Response,
Institute of Science and Technology Austria, 2021.
date_created: 2021-11-18T15:05:06Z
date_published: 2021-11-18T00:00:00Z
date_updated: 2023-09-07T13:34:38Z
day: '18'
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- _id: CaGu
- _id: GradSch
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status: public
supervisor:
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full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-4561-241X
- first_name: Calin C
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id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
title: Pathogenic Escherichia coli hijack the host immune response
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
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...
---
_id: '10316'
abstract:
- lang: eng
text: A key attribute of persistent or recurring bacterial infections is the ability
of the pathogen to evade the host’s immune response. Many Enterobacteriaceae express
type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and
establish persistent infections. However, the molecular mechanisms and strategies
by which bacteria actively circumvent the immune response of the host remain poorly
understood. Here, we identified CD14, the major co-receptor for lipopolysaccharide
detection, on dendritic cells as a previously undescribed binding partner of FimH,
the protein located at the tip of the type 1 pilus of Escherichia coli. The FimH
amino acids involved in CD14 binding are highly conserved across pathogenic and
non-pathogenic strains. Binding of pathogenic bacteria to CD14 lead to reduced
dendritic cell migration and blunted expression of co-stimulatory molecules, both
rate-limiting factors of T cell activation. While defining an active molecular
mechanism of immune evasion by pathogens, the interaction between FimH and CD14
represents a potential target to interfere with persistent and recurrent infections,
such as urinary tract infections or Crohn’s disease.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: EM-Fac
acknowledgement: We thank Ulrich Dobrindt for providing UPEC strain CFT073, Vlad Gavra
and Maximilian Götz, Bor Kavčič, Jonna Alanko and Eva Kiermaier for help with experiments
and Robert Hauschild, Julian Stopp and Saren Tasciyan for help with data analysis.
We thank the IST Austria Scientific Service Units, especially the Bioimaging facility,
the Preclinical facility and the Electron microscopy facility for technical support,
Jakob Wallner and all members of the Guet and Sixt lab for fruitful discussions
and Daria Siekhaus for critically reading the manuscript. This work was supported
by grants from the Austrian Research Promotion Agency (FEMtech 868984) to I.G.,
the European Research Council (CoG 724373) and the Austrian Science Fund (FWF P29911)
to M.S.
article_processing_charge: No
author:
- first_name: Kathrin
full_name: Tomasek, Kathrin
id: 3AEC8556-F248-11E8-B48F-1D18A9856A87
last_name: Tomasek
orcid: 0000-0003-3768-877X
- first_name: Alexander F
full_name: Leithner, Alexander F
id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87
last_name: Leithner
orcid: 0000-0002-1073-744X
- first_name: Ivana
full_name: Glatzová, Ivana
id: 727b3c7d-4939-11ec-89b3-b9b0750ab74d
last_name: Glatzová
- first_name: Michael S.
full_name: Lukesch, Michael S.
last_name: Lukesch
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-4561-241X
citation:
ama: Tomasek K, Leithner AF, Glatzová I, Lukesch MS, Guet CC, Sixt MK. Type 1 piliated
uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
bioRxiv. doi:10.1101/2021.10.18.464770
apa: Tomasek, K., Leithner, A. F., Glatzová, I., Lukesch, M. S., Guet, C. C., &
Sixt, M. K. (n.d.). Type 1 piliated uropathogenic Escherichia coli hijack the
host immune response by binding to CD14. bioRxiv. Cold Spring Harbor Laboratory.
https://doi.org/10.1101/2021.10.18.464770
chicago: Tomasek, Kathrin, Alexander F Leithner, Ivana Glatzová, Michael S. Lukesch,
Calin C Guet, and Michael K Sixt. “Type 1 Piliated Uropathogenic Escherichia Coli
Hijack the Host Immune Response by Binding to CD14.” BioRxiv. Cold Spring
Harbor Laboratory, n.d. https://doi.org/10.1101/2021.10.18.464770.
ieee: K. Tomasek, A. F. Leithner, I. Glatzová, M. S. Lukesch, C. C. Guet, and M.
K. Sixt, “Type 1 piliated uropathogenic Escherichia coli hijack the host immune
response by binding to CD14,” bioRxiv. Cold Spring Harbor Laboratory.
ista: Tomasek K, Leithner AF, Glatzová I, Lukesch MS, Guet CC, Sixt MK. Type 1 piliated
uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
bioRxiv, 10.1101/2021.10.18.464770.
mla: Tomasek, Kathrin, et al. “Type 1 Piliated Uropathogenic Escherichia Coli Hijack
the Host Immune Response by Binding to CD14.” BioRxiv, Cold Spring Harbor
Laboratory, doi:10.1101/2021.10.18.464770.
short: K. Tomasek, A.F. Leithner, I. Glatzová, M.S. Lukesch, C.C. Guet, M.K. Sixt,
BioRxiv (n.d.).
date_created: 2021-11-19T12:24:16Z
date_published: 2021-10-18T00:00:00Z
date_updated: 2024-03-27T23:30:35Z
day: '18'
department:
- _id: CaGu
- _id: MiSi
doi: 10.1101/2021.10.18.464770
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2021.10.18.464770v1
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '724373'
name: Cellular navigation along spatial gradients
- _id: 26018E70-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29911
name: Mechanical adaptation of lamellipodial actin
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
related_material:
record:
- id: '11843'
relation: later_version
status: public
- id: '10307'
relation: dissertation_contains
status: public
status: public
title: Type 1 piliated uropathogenic Escherichia coli hijack the host immune response
by binding to CD14
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '9010'
abstract:
- lang: eng
text: Availability of the essential macronutrient nitrogen in soil plays a critical
role in plant growth, development, and impacts agricultural productivity. Plants
have evolved different strategies for sensing and responding to heterogeneous
nitrogen distribution. Modulation of root system architecture, including primary
root growth and branching, is among the most essential plant adaptions to ensure
adequate nitrogen acquisition. However, the immediate molecular pathways coordinating
the adjustment of root growth in response to distinct nitrogen sources, such as
nitrate or ammonium, are poorly understood. Here, we show that growth as manifested
by cell division and elongation is synchronized by coordinated auxin flux between
two adjacent outer tissue layers of the root. This coordination is achieved by
nitrate‐dependent dephosphorylation of the PIN2 auxin efflux carrier at a previously
uncharacterized phosphorylation site, leading to subsequent PIN2 lateralization
and thereby regulating auxin flow between adjacent tissues. A dynamic computer
model based on our experimental data successfully recapitulates experimental observations.
Our study provides mechanistic insights broadening our understanding of root growth
mechanisms in dynamic environments.
acknowledged_ssus:
- _id: Bio
acknowledgement: 'We acknowledge Gergely Molnar for critical reading of the manuscript,
Alexander Johnson for language editing and Yulija Salanenka for technical assistance.
Work in the Benkova laboratory was supported by the Austrian Science Fund (FWF01_I1774S)
to KO, RA and EB. Work in the Benkova laboratory was supported by the Austrian Science
Fund (FWF01_I1774S) to KO, RA and EB and by the DOC Fellowship Programme of the
AustrianAcademy of Sciences (25008) to C.A. Work in the Wabnik laboratory was supported
by the Programa de Atraccion de Talento 2017 (Comunidad deMadrid, 2017-T1/BIO-5654
to K.W.), Severo Ochoa Programme for Centres of Excellence in R&D from the Agencia
Estatal de Investigacion of Spain (grantSEV-2016-0672 (2017-2021) to K.W. via the
CBGP) and Programa Estatal de Generacion del Conocimiento y Fortalecimiento Científico
y Tecnologico del Sistema de I+D+I 2019 (PGC2018-093387-A-I00) from MICIU (to K.W.).
M.M.was supported by a postdoctoral contract associated to SEV-2016-0672.We acknowledge
the Bioimaging Facility in IST-Austria and the Advanced Microscopy Facility of the
Vienna Bio Center Core Facilities, member of the Vienna Bio Center Austria, for
use of the OMX v43D SIM microscope. AJ was supported by the Austrian Science Fund
(FWF): I03630 to J.F'
article_number: e106862
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Krisztina
full_name: Ötvös, Krisztina
id: 29B901B0-F248-11E8-B48F-1D18A9856A87
last_name: Ötvös
orcid: 0000-0002-5503-4983
- first_name: Marco
full_name: Marconi, Marco
last_name: Marconi
- first_name: Andrea
full_name: Vega, Andrea
last_name: Vega
- first_name: Jose
full_name: O’Brien, Jose
last_name: O’Brien
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: Rashed
full_name: Abualia, Rashed
id: 4827E134-F248-11E8-B48F-1D18A9856A87
last_name: Abualia
orcid: 0000-0002-9357-9415
- first_name: Livio
full_name: Antonielli, Livio
last_name: Antonielli
- first_name: Juan C
full_name: Montesinos López, Juan C
id: 310A8E3E-F248-11E8-B48F-1D18A9856A87
last_name: Montesinos López
orcid: 0000-0001-9179-6099
- first_name: Yuzhou
full_name: Zhang, Yuzhou
id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0003-2627-6956
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Candela
full_name: Cuesta, Candela
id: 33A3C818-F248-11E8-B48F-1D18A9856A87
last_name: Cuesta
orcid: 0000-0003-1923-2410
- first_name: Christina
full_name: Artner, Christina
id: 45DF286A-F248-11E8-B48F-1D18A9856A87
last_name: Artner
- first_name: Eleonore
full_name: Bouguyon, Eleonore
last_name: Bouguyon
- first_name: Alain
full_name: Gojon, Alain
last_name: Gojon
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Rodrigo A.
full_name: Gutiérrez, Rodrigo A.
last_name: Gutiérrez
- first_name: Krzysztof T
full_name: Wabnik, Krzysztof T
id: 4DE369A4-F248-11E8-B48F-1D18A9856A87
last_name: Wabnik
orcid: 0000-0001-7263-0560
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
citation:
ama: Ötvös K, Marconi M, Vega A, et al. Modulation of plant root growth by nitrogen
source-defined regulation of polar auxin transport. EMBO Journal. 2021;40(3).
doi:10.15252/embj.2020106862
apa: Ötvös, K., Marconi, M., Vega, A., O’Brien, J., Johnson, A. J., Abualia, R.,
… Benková, E. (2021). Modulation of plant root growth by nitrogen source-defined
regulation of polar auxin transport. EMBO Journal. Embo Press. https://doi.org/10.15252/embj.2020106862
chicago: Ötvös, Krisztina, Marco Marconi, Andrea Vega, Jose O’Brien, Alexander J
Johnson, Rashed Abualia, Livio Antonielli, et al. “Modulation of Plant Root Growth
by Nitrogen Source-Defined Regulation of Polar Auxin Transport.” EMBO Journal.
Embo Press, 2021. https://doi.org/10.15252/embj.2020106862.
ieee: K. Ötvös et al., “Modulation of plant root growth by nitrogen source-defined
regulation of polar auxin transport,” EMBO Journal, vol. 40, no. 3. Embo
Press, 2021.
ista: Ötvös K, Marconi M, Vega A, O’Brien J, Johnson AJ, Abualia R, Antonielli L,
Montesinos López JC, Zhang Y, Tan S, Cuesta C, Artner C, Bouguyon E, Gojon A,
Friml J, Gutiérrez RA, Wabnik KT, Benková E. 2021. Modulation of plant root growth
by nitrogen source-defined regulation of polar auxin transport. EMBO Journal.
40(3), e106862.
mla: Ötvös, Krisztina, et al. “Modulation of Plant Root Growth by Nitrogen Source-Defined
Regulation of Polar Auxin Transport.” EMBO Journal, vol. 40, no. 3, e106862,
Embo Press, 2021, doi:10.15252/embj.2020106862.
short: K. Ötvös, M. Marconi, A. Vega, J. O’Brien, A.J. Johnson, R. Abualia, L. Antonielli,
J.C. Montesinos López, Y. Zhang, S. Tan, C. Cuesta, C. Artner, E. Bouguyon, A.
Gojon, J. Friml, R.A. Gutiérrez, K.T. Wabnik, E. Benková, EMBO Journal 40 (2021).
date_created: 2021-01-17T23:01:12Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2024-03-27T23:30:39Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
- _id: EvBe
doi: 10.15252/embj.2020106862
external_id:
isi:
- '000604645600001'
pmid:
- ' 33399250'
file:
- access_level: open_access
checksum: dc55c900f3b061d6c2790b8813d759a3
content_type: application/pdf
creator: dernst
date_created: 2021-02-11T12:28:29Z
date_updated: 2021-02-11T12:28:29Z
file_id: '9110'
file_name: 2021_Embo_Otvos.pdf
file_size: 2358617
relation: main_file
success: 1
file_date_updated: 2021-02-11T12:28:29Z
has_accepted_license: '1'
intvolume: ' 40'
isi: 1
issue: '3'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2542D156-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I 1774-B16
name: Hormone cross-talk drives nutrient dependent plant development
- _id: 2685A872-B435-11E9-9278-68D0E5697425
name: Hormonal regulation of plant adaptive responses to environmental signals
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
publication: EMBO Journal
publication_identifier:
eissn:
- '14602075'
issn:
- '02614189'
publication_status: published
publisher: Embo Press
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/a-plants-way-to-its-favorite-food/
record:
- id: '10303'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Modulation of plant root growth by nitrogen source-defined regulation of polar
auxin transport
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 40
year: '2021'
...
---
_id: '9913'
abstract:
- lang: eng
text: Nitrate commands genome-wide gene expression changes that impact metabolism,
physiology, plant growth, and development. In an effort to identify new components
involved in nitrate responses in plants, we analyze the Arabidopsis thaliana root
phosphoproteome in response to nitrate treatments via liquid chromatography coupled
to tandem mass spectrometry. 176 phosphoproteins show significant changes at 5
or 20 min after nitrate treatments. Proteins identified by 5 min include signaling
components such as kinases or transcription factors. In contrast, by 20 min, proteins
identified were associated with transporter activity or hormone metabolism functions,
among others. The phosphorylation profile of NITRATE TRANSPORTER 1.1 (NRT1.1)
mutant plants was significantly altered as compared to wild-type plants, confirming
its key role in nitrate signaling pathways that involves phosphorylation changes.
Integrative bioinformatics analysis highlights auxin transport as an important
mechanism modulated by nitrate signaling at the post-translational level. We validated
a new phosphorylation site in PIN2 and provide evidence that it functions in primary
and lateral root growth responses to nitrate.
acknowledgement: This work was supported by ANID—Millennium Science Initiative Program—ICN17_022,
Fondo de Desarrollo de Areas Prioritarias (FONDAP) Center for Genome Regulation
(15090007), ANID—Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT)
1180759 (to RAG) and 1171631 (to AV). We would like to thank Unidad de Microscopía
Avanzada UC (UMA UC).
article_number: e51813
article_processing_charge: Yes
article_type: original
author:
- first_name: Andrea
full_name: Vega, Andrea
last_name: Vega
- first_name: Isabel
full_name: Fredes, Isabel
last_name: Fredes
- first_name: José
full_name: O’Brien, José
last_name: O’Brien
- first_name: Zhouxin
full_name: Shen, Zhouxin
last_name: Shen
- first_name: Krisztina
full_name: Ötvös, Krisztina
id: 29B901B0-F248-11E8-B48F-1D18A9856A87
last_name: Ötvös
orcid: 0000-0002-5503-4983
- first_name: Rashed
full_name: Abualia, Rashed
id: 4827E134-F248-11E8-B48F-1D18A9856A87
last_name: Abualia
orcid: 0000-0002-9357-9415
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Steven P.
full_name: Briggs, Steven P.
last_name: Briggs
- first_name: Rodrigo A.
full_name: Gutiérrez, Rodrigo A.
last_name: Gutiérrez
citation:
ama: Vega A, Fredes I, O’Brien J, et al. Nitrate triggered phosphoproteome changes
and a PIN2 phosphosite modulating root system architecture. EMBO Reports.
2021;22(9). doi:10.15252/embr.202051813
apa: Vega, A., Fredes, I., O’Brien, J., Shen, Z., Ötvös, K., Abualia, R., … Gutiérrez,
R. A. (2021). Nitrate triggered phosphoproteome changes and a PIN2 phosphosite
modulating root system architecture. EMBO Reports. Wiley. https://doi.org/10.15252/embr.202051813
chicago: Vega, Andrea, Isabel Fredes, José O’Brien, Zhouxin Shen, Krisztina Ötvös,
Rashed Abualia, Eva Benková, Steven P. Briggs, and Rodrigo A. Gutiérrez. “Nitrate
Triggered Phosphoproteome Changes and a PIN2 Phosphosite Modulating Root System
Architecture.” EMBO Reports. Wiley, 2021. https://doi.org/10.15252/embr.202051813.
ieee: A. Vega et al., “Nitrate triggered phosphoproteome changes and a PIN2
phosphosite modulating root system architecture,” EMBO Reports, vol. 22,
no. 9. Wiley, 2021.
ista: Vega A, Fredes I, O’Brien J, Shen Z, Ötvös K, Abualia R, Benková E, Briggs
SP, Gutiérrez RA. 2021. Nitrate triggered phosphoproteome changes and a PIN2 phosphosite
modulating root system architecture. EMBO Reports. 22(9), e51813.
mla: Vega, Andrea, et al. “Nitrate Triggered Phosphoproteome Changes and a PIN2
Phosphosite Modulating Root System Architecture.” EMBO Reports, vol. 22,
no. 9, e51813, Wiley, 2021, doi:10.15252/embr.202051813.
short: A. Vega, I. Fredes, J. O’Brien, Z. Shen, K. Ötvös, R. Abualia, E. Benková,
S.P. Briggs, R.A. Gutiérrez, EMBO Reports 22 (2021).
date_created: 2021-08-15T22:01:30Z
date_published: 2021-09-06T00:00:00Z
date_updated: 2024-03-27T23:30:39Z
day: '06'
ddc:
- '580'
department:
- _id: EvBe
- _id: GradSch
doi: 10.15252/embr.202051813
external_id:
isi:
- '000681754200001'
pmid:
- '34357701 '
file:
- access_level: open_access
checksum: 750de03dc3b715c37090126c1548ba13
content_type: application/pdf
creator: cchlebak
date_created: 2021-10-05T13:36:42Z
date_updated: 2021-10-05T13:36:42Z
file_id: '10090'
file_name: 2021_EmboR_Vega.pdf
file_size: 3144854
relation: main_file
success: 1
file_date_updated: 2021-10-05T13:36:42Z
has_accepted_license: '1'
intvolume: ' 22'
isi: 1
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
publication: EMBO Reports
publication_identifier:
eissn:
- 1469-3178
issn:
- 1469-221X
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '10303'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Nitrate triggered phosphoproteome changes and a PIN2 phosphosite modulating
root system architecture
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 22
year: '2021'
...
---
_id: '10303'
abstract:
- lang: eng
text: 'Nitrogen is an essential macronutrient determining plant growth, development
and affecting agricultural productivity. Root, as a hub that perceives and integrates
local and systemic signals on the plant’s external and endogenous nitrogen resources,
communicates with other plant organs to consolidate their physiology and development
in accordance with actual nitrogen balance. Over the last years, numerous studies
demonstrated that these comprehensive developmental adaptations rely on the interaction
between pathways controlling nitrogen homeostasis and hormonal networks acting
globally in the plant body. However, molecular insights into how the information
about the nitrogen status is translated through hormonal pathways into specific
developmental output are lacking. In my work, I addressed so far poorly understood
mechanisms underlying root-to-shoot communication that lead to a rapid re-adjustment
of shoot growth and development after nitrate provision. Applying a combination
of molecular, cell, and developmental biology approaches, genetics and grafting
experiments as well as hormonal analytics, I identified and characterized an unknown
molecular framework orchestrating shoot development with a root nitrate sensory
system. '
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Rashed
full_name: Abualia, Rashed
id: 4827E134-F248-11E8-B48F-1D18A9856A87
last_name: Abualia
orcid: 0000-0002-9357-9415
citation:
ama: Abualia R. Role of hormones in nitrate regulated growth. 2021. doi:10.15479/at:ista:10303
apa: Abualia, R. (2021). Role of hormones in nitrate regulated growth. Institute
of Science and Technology Austria. https://doi.org/10.15479/at:ista:10303
chicago: Abualia, Rashed. “Role of Hormones in Nitrate Regulated Growth.” Institute
of Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:10303.
ieee: R. Abualia, “Role of hormones in nitrate regulated growth,” Institute of Science
and Technology Austria, 2021.
ista: Abualia R. 2021. Role of hormones in nitrate regulated growth. Institute of
Science and Technology Austria.
mla: Abualia, Rashed. Role of Hormones in Nitrate Regulated Growth. Institute
of Science and Technology Austria, 2021, doi:10.15479/at:ista:10303.
short: R. Abualia, Role of Hormones in Nitrate Regulated Growth, Institute of Science
and Technology Austria, 2021.
date_created: 2021-11-18T11:20:59Z
date_published: 2021-11-22T00:00:00Z
date_updated: 2023-09-19T14:42:45Z
day: '22'
ddc:
- '580'
- '581'
degree_awarded: PhD
department:
- _id: GradSch
- _id: EvBe
doi: 10.15479/at:ista:10303
file:
- access_level: open_access
checksum: dea38b98aa4da1cea03dcd0f10862818
content_type: application/pdf
creator: rabualia
date_created: 2021-11-22T14:48:21Z
date_updated: 2022-12-20T23:30:06Z
embargo: 2022-11-23
file_id: '10331'
file_name: AbualiaPhDthesisfinalv3.pdf
file_size: 28005730
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page: '139'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
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status: public
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relation: part_of_dissertation
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status: public
supervisor:
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
title: Role of hormones in nitrate regulated growth
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '9962'
abstract:
- lang: eng
text: The brain is one of the largest and most complex organs and it is composed
of billions of neurons that communicate together enabling e.g. consciousness.
The cerebral cortex is the largest site of neural integration in the central nervous
system. Concerted radial migration of newly born cortical projection neurons,
from their birthplace to their final position, is a key step in the assembly of
the cerebral cortex. The cellular and molecular mechanisms regulating radial neuronal
migration in vivo are however still unclear. Recent evidence suggests that distinct
signaling cues act cell-autonomously but differentially at certain steps during
the overall migration process. Moreover, functional analysis of genetic mosaics
(mutant neurons present in wild-type/heterozygote environment) using the MADM
(Mosaic Analysis with Double Markers) analyses in comparison to global knockout
also indicate a significant degree of non-cell-autonomous and/or community effects
in the control of cortical neuron migration. The interactions of cell-intrinsic
(cell-autonomous) and cell-extrinsic (non-cell-autonomous) components are largely
unknown. In part of this thesis work we established a MADM-based experimental
strategy for the quantitative analysis of cell-autonomous gene function versus
non-cell-autonomous and/or community effects. The direct comparison of mutant
neurons from the genetic mosaic (cell-autonomous) to mutant neurons in the conditional
and/or global knockout (cell-autonomous + non-cell-autonomous) allows to quantitatively
analyze non-cell-autonomous effects. Such analysis enable the high-resolution
analysis of projection neuron migration dynamics in distinct environments with
concomitant isolation of genomic and proteomic profiles. Using these experimental
paradigms and in combination with computational modeling we show and characterize
the nature of non-cell-autonomous effects to coordinate radial neuron migration.
Furthermore, this thesis discusses recent developments in neurodevelopment with
focus on neuronal polarization and non-cell-autonomous mechanisms in neuronal
migration.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Andi H
full_name: Hansen, Andi H
id: 38853E16-F248-11E8-B48F-1D18A9856A87
last_name: Hansen
citation:
ama: Hansen AH. Cell-autonomous gene function and non-cell-autonomous effects in
radial projection neuron migration. 2021. doi:10.15479/at:ista:9962
apa: Hansen, A. H. (2021). Cell-autonomous gene function and non-cell-autonomous
effects in radial projection neuron migration. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:9962
chicago: Hansen, Andi H. “Cell-Autonomous Gene Function and Non-Cell-Autonomous
Effects in Radial Projection Neuron Migration.” Institute of Science and Technology
Austria, 2021. https://doi.org/10.15479/at:ista:9962.
ieee: A. H. Hansen, “Cell-autonomous gene function and non-cell-autonomous effects
in radial projection neuron migration,” Institute of Science and Technology Austria,
2021.
ista: Hansen AH. 2021. Cell-autonomous gene function and non-cell-autonomous effects
in radial projection neuron migration. Institute of Science and Technology Austria.
mla: Hansen, Andi H. Cell-Autonomous Gene Function and Non-Cell-Autonomous Effects
in Radial Projection Neuron Migration. Institute of Science and Technology
Austria, 2021, doi:10.15479/at:ista:9962.
short: A.H. Hansen, Cell-Autonomous Gene Function and Non-Cell-Autonomous Effects
in Radial Projection Neuron Migration, Institute of Science and Technology Austria,
2021.
date_created: 2021-08-29T12:36:50Z
date_published: 2021-09-02T00:00:00Z
date_updated: 2023-09-22T09:58:30Z
day: '02'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: SiHi
doi: 10.15479/at:ista:9962
file:
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creator: ahansen
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file_id: '9971'
file_name: Thesis_Hansen.docx
file_size: 10629190
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content_type: application/pdf
creator: ahansen
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date_updated: 2022-09-03T22:30:04Z
embargo: 2022-09-02
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file_name: Thesis_Hansen_PDFA-1a.pdf
file_size: 13457469
relation: main_file
file_date_updated: 2022-09-03T22:30:04Z
has_accepted_license: '1'
keyword:
- Neuronal migration
- Non-cell-autonomous
- Cell-autonomous
- Neurodevelopmental disease
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '182'
project:
- _id: 2625A13E-B435-11E9-9278-68D0E5697425
grant_number: '24812'
name: Molecular Mechanisms of Radial Neuronal Migration
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8569'
relation: part_of_dissertation
status: public
- id: '960'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
title: Cell-autonomous gene function and non-cell-autonomous effects in radial projection
neuron migration
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '9428'
abstract:
- lang: eng
text: Thermalization is the inevitable fate of many complex quantum systems, whose
dynamics allow them to fully explore the vast configuration space regardless of
the initial state---the behaviour known as quantum ergodicity. In a quest for
experimental realizations of coherent long-time dynamics, efforts have focused
on ergodicity-breaking mechanisms, such as integrability and localization. The
recent discovery of persistent revivals in quantum simulators based on Rydberg
atoms have pointed to the existence of a new type of behaviour where the system
rapidly relaxes for most initial conditions, while certain initial states give
rise to non-ergodic dynamics. This collective effect has been named ”quantum many-body
scarring’by analogy with a related form of weak ergodicity breaking that occurs
for a single particle inside a stadium billiard potential. In this Review, we
provide a pedagogical introduction to quantum many-body scars and highlight the
emerging connections with the semiclassical quantization of many-body systems.
We discuss the relation between scars and more general routes towards weak violations
of ergodicity due to embedded algebras and non-thermal eigenstates, and highlight
possible applications of scars in quantum technology.
acknowledgement: We thank our collaborators K. Bull, S. Choi, J.-Y. Desaules, W. W.
Ho, A. Hudomal, M. Lukin, I. Martin, H. Pichler, N. Regnault, I. Vasić and in particular
A. Michailidis and C. Turner, without whom this work would not have been possible.
We also benefited from discussions with E. Altman, B. A. Bernevig, A. Chandran,
P. Fendley, V. Khemani and L. Motrunich. M.S. was supported by the European Research
Council (ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement no. 850899). D.A.A. was supported by the Swiss National Science
Foundation and by the ERC under the European Union’s Horizon 2020 research and innovation
programme (grant agreement no. 864597). Z.P. acknowledges support by the Leverhulme
Trust Research Leadership Award RL-2019-015.
article_processing_charge: No
article_type: review
author:
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
- first_name: Dmitry A.
full_name: Abanin, Dmitry A.
last_name: Abanin
- first_name: Zlatko
full_name: Papić, Zlatko
last_name: Papić
citation:
ama: Serbyn M, Abanin DA, Papić Z. Quantum many-body scars and weak breaking of
ergodicity. Nature Physics. 2021;17(6):675–685. doi:10.1038/s41567-021-01230-2
apa: Serbyn, M., Abanin, D. A., & Papić, Z. (2021). Quantum many-body scars
and weak breaking of ergodicity. Nature Physics. Nature Research. https://doi.org/10.1038/s41567-021-01230-2
chicago: Serbyn, Maksym, Dmitry A. Abanin, and Zlatko Papić. “Quantum Many-Body
Scars and Weak Breaking of Ergodicity.” Nature Physics. Nature Research,
2021. https://doi.org/10.1038/s41567-021-01230-2.
ieee: M. Serbyn, D. A. Abanin, and Z. Papić, “Quantum many-body scars and weak breaking
of ergodicity,” Nature Physics, vol. 17, no. 6. Nature Research, pp. 675–685,
2021.
ista: Serbyn M, Abanin DA, Papić Z. 2021. Quantum many-body scars and weak breaking
of ergodicity. Nature Physics. 17(6), 675–685.
mla: Serbyn, Maksym, et al. “Quantum Many-Body Scars and Weak Breaking of Ergodicity.”
Nature Physics, vol. 17, no. 6, Nature Research, 2021, pp. 675–685, doi:10.1038/s41567-021-01230-2.
short: M. Serbyn, D.A. Abanin, Z. Papić, Nature Physics 17 (2021) 675–685.
date_created: 2021-05-28T09:03:50Z
date_published: 2021-06-01T00:00:00Z
date_updated: 2023-10-18T08:20:59Z
day: '01'
ddc:
- '539'
department:
- _id: MaSe
doi: 10.1038/s41567-021-01230-2
ec_funded: 1
external_id:
arxiv:
- '2011.09486'
isi:
- '000655563800002'
file:
- access_level: open_access
checksum: 316ed42ea1b42b0f1a3025bb476266fc
content_type: application/pdf
creator: patrickd
date_created: 2021-09-20T09:27:43Z
date_updated: 2021-12-02T23:30:03Z
embargo: 2021-12-01
file_id: '10026'
file_name: RevisedQMBSreview.pdf
file_size: 10028836
relation: main_file
file_date_updated: 2021-12-02T23:30:03Z
has_accepted_license: '1'
intvolume: ' 17'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Preprint
page: 675–685
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
publication_status: published
publisher: Nature Research
quality_controlled: '1'
status: public
title: Quantum many-body scars and weak breaking of ergodicity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2021'
...
---
_id: '8931'
abstract:
- lang: eng
text: "Auxin is a major plant growth regulator, but current models on auxin perception
and signaling cannot explain the whole plethora of auxin effects, in particular
those associated with rapid responses. A possible candidate for a component of
additional auxin perception mechanisms is the AUXIN BINDING PROTEIN 1 (ABP1),
whose function in planta remains unclear.\r\nHere we combined expression analysis
with gain- and loss-of-function approaches to analyze the role of ABP1 in plant
development. ABP1 shows a broad expression largely overlapping with, but not regulated
by, transcriptional auxin response activity. Furthermore, ABP1 activity is not
essential for the transcriptional auxin signaling. Genetic in planta analysis
revealed that abp1 loss-of-function mutants show largely normal development with
minor defects in bolting. On the other hand, ABP1 gain-of-function alleles show
a broad range of growth and developmental defects, including root and hypocotyl
growth and bending, lateral root and leaf development, bolting, as well as response
to heat stress. At the cellular level, ABP1 gain-of-function leads to impaired
auxin effect on PIN polar distribution and affects BFA-sensitive PIN intracellular
aggregation.\r\nThe gain-of-function analysis suggests a broad, but still mechanistically
unclear involvement of ABP1 in plant development, possibly masked in abp1 loss-of-function
mutants by a functional redundancy."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We would like to acknowledge Bioimaging and Life Science Facilities
at IST Austria for continuous support and also the Plant Sciences Core Facility
of CEITEC Masaryk University for their support with obtaining a part of the scientific
data. We gratefully acknowledge Lindy Abas for help with ABP1::GFP-ABP1 construct
design. This project has received funding from the European Research Council (ERC)
under the European Union’s Horizon 2020 research and innovation program [grant agreement
no. 742985] and Austrian Science Fund (FWF) [I 3630-B25] to J.F.; DOC Fellowship
of the Austrian Academy of Sciences to L.L.; the European Structural and Investment
Funds, Operational Programme Research, Development and Education - Project „MSCAfellow@MUNI“
[CZ.02.2.69/0.0/0.0/17_050/0008496] to M.P.. This project was also supported by
the Czech Science Foundation [GA 20-20860Y] to M.Z and MEYS CR [project no.CZ.02.1.01/0.0/0.0/16_019/0000738]
to M. Č.
article_number: '110750'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Zuzana
full_name: Gelová, Zuzana
id: 0AE74790-0E0B-11E9-ABC7-1ACFE5697425
last_name: Gelová
orcid: 0000-0003-4783-1752
- first_name: Michelle C
full_name: Gallei, Michelle C
id: 35A03822-F248-11E8-B48F-1D18A9856A87
last_name: Gallei
orcid: 0000-0003-1286-7368
- first_name: Markéta
full_name: Pernisová, Markéta
last_name: Pernisová
- first_name: Géraldine
full_name: Brunoud, Géraldine
last_name: Brunoud
- first_name: Xixi
full_name: Zhang, Xixi
id: 61A66458-47E9-11EA-85BA-8AEAAF14E49A
last_name: Zhang
orcid: 0000-0001-7048-4627
- first_name: Matous
full_name: Glanc, Matous
id: 1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
last_name: Glanc
orcid: 0000-0003-0619-7783
- first_name: Lanxin
full_name: Li, Lanxin
id: 367EF8FA-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0002-5607-272X
- first_name: Jaroslav
full_name: Michalko, Jaroslav
id: 483727CA-F248-11E8-B48F-1D18A9856A87
last_name: Michalko
- first_name: Zlata
full_name: Pavlovicova, Zlata
last_name: Pavlovicova
- first_name: Inge
full_name: Verstraeten, Inge
id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
last_name: Verstraeten
orcid: 0000-0001-7241-2328
- first_name: Huibin
full_name: Han, Huibin
id: 31435098-F248-11E8-B48F-1D18A9856A87
last_name: Han
- first_name: Jakub
full_name: Hajny, Jakub
id: 4800CC20-F248-11E8-B48F-1D18A9856A87
last_name: Hajny
orcid: 0000-0003-2140-7195
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Milada
full_name: Čovanová, Milada
last_name: Čovanová
- first_name: Marta
full_name: Zwiewka, Marta
last_name: Zwiewka
- first_name: Lukas
full_name: Hörmayer, Lukas
id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87
last_name: Hörmayer
orcid: 0000-0001-8295-2926
- first_name: Matyas
full_name: Fendrych, Matyas
id: 43905548-F248-11E8-B48F-1D18A9856A87
last_name: Fendrych
orcid: 0000-0002-9767-8699
- first_name: Tongda
full_name: Xu, Tongda
last_name: Xu
- first_name: Teva
full_name: Vernoux, Teva
last_name: Vernoux
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Gelová Z, Gallei MC, Pernisová M, et al. Developmental roles of auxin binding
protein 1 in Arabidopsis thaliana. Plant Science. 2021;303. doi:10.1016/j.plantsci.2020.110750
apa: Gelová, Z., Gallei, M. C., Pernisová, M., Brunoud, G., Zhang, X., Glanc, M.,
… Friml, J. (2021). Developmental roles of auxin binding protein 1 in Arabidopsis
thaliana. Plant Science. Elsevier. https://doi.org/10.1016/j.plantsci.2020.110750
chicago: Gelová, Zuzana, Michelle C Gallei, Markéta Pernisová, Géraldine Brunoud,
Xixi Zhang, Matous Glanc, Lanxin Li, et al. “Developmental Roles of Auxin Binding
Protein 1 in Arabidopsis Thaliana.” Plant Science. Elsevier, 2021. https://doi.org/10.1016/j.plantsci.2020.110750.
ieee: Z. Gelová et al., “Developmental roles of auxin binding protein 1 in
Arabidopsis thaliana,” Plant Science, vol. 303. Elsevier, 2021.
ista: Gelová Z, Gallei MC, Pernisová M, Brunoud G, Zhang X, Glanc M, Li L, Michalko
J, Pavlovicova Z, Verstraeten I, Han H, Hajny J, Hauschild R, Čovanová M, Zwiewka
M, Hörmayer L, Fendrych M, Xu T, Vernoux T, Friml J. 2021. Developmental roles
of auxin binding protein 1 in Arabidopsis thaliana. Plant Science. 303, 110750.
mla: Gelová, Zuzana, et al. “Developmental Roles of Auxin Binding Protein 1 in Arabidopsis
Thaliana.” Plant Science, vol. 303, 110750, Elsevier, 2021, doi:10.1016/j.plantsci.2020.110750.
short: Z. Gelová, M.C. Gallei, M. Pernisová, G. Brunoud, X. Zhang, M. Glanc, L.
Li, J. Michalko, Z. Pavlovicova, I. Verstraeten, H. Han, J. Hajny, R. Hauschild,
M. Čovanová, M. Zwiewka, L. Hörmayer, M. Fendrych, T. Xu, T. Vernoux, J. Friml,
Plant Science 303 (2021).
date_created: 2020-12-09T14:48:28Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2024-03-27T23:30:43Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
- _id: Bio
doi: 10.1016/j.plantsci.2020.110750
ec_funded: 1
external_id:
isi:
- '000614154500001'
pmid:
- '33487339'
file:
- access_level: open_access
checksum: a7f2562bdca62d67dfa88e271b62a629
content_type: application/pdf
creator: dernst
date_created: 2021-02-04T07:49:25Z
date_updated: 2021-02-04T07:49:25Z
file_id: '9083'
file_name: 2021_PlantScience_Gelova.pdf
file_size: 12563728
relation: main_file
success: 1
file_date_updated: 2021-02-04T07:49:25Z
has_accepted_license: '1'
intvolume: ' 303'
isi: 1
keyword:
- Agronomy and Crop Science
- Plant Science
- Genetics
- General Medicine
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
- _id: 26B4D67E-B435-11E9-9278-68D0E5697425
grant_number: '25351'
name: 'A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated
Rapid Growth Inhibition in Arabidopsis Root'
publication: Plant Science
publication_identifier:
issn:
- 0168-9452
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '11626'
relation: dissertation_contains
status: public
- id: '10083'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Developmental roles of auxin binding protein 1 in Arabidopsis thaliana
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 303
year: '2021'
...
---
_id: '9287'
abstract:
- lang: eng
text: "The phytohormone auxin and its directional transport through tissues are
intensively studied. However, a mechanistic understanding of auxin-mediated feedback
on endocytosis and polar distribution of PIN auxin transporters remains limited
due to contradictory observations and interpretations. Here, we used state-of-the-art
methods to reexamine the\r\nauxin effects on PIN endocytic trafficking. We used
high auxin concentrations or longer treatments versus lower concentrations and
shorter treatments of natural (IAA) and synthetic (NAA) auxins to distinguish
between specific and nonspecific effects. Longer treatments of both auxins interfere
with Brefeldin A-mediated intracellular PIN2 accumulation and also with general
aggregation of endomembrane compartments. NAA treatment decreased the internalization
of the endocytic tracer dye, FM4-64; however, NAA treatment also affected the
number, distribution, and compartment identity of the early endosome/trans-Golgi
network (EE/TGN), rendering the FM4-64 endocytic assays at high NAA concentrations
unreliable. To circumvent these nonspecific effects of NAA and IAA affecting the
endomembrane system, we opted for alternative approaches visualizing the endocytic
events directly at the plasma membrane (PM). Using Total Internal Reflection Fluorescence
(TIRF) microscopy, we saw no significant effects of IAA or NAA treatments on the
incidence and dynamics of clathrin foci, implying that these treatments do not
affect the overall endocytosis rate. However, both NAA and IAA at low concentrations
rapidly and specifically promoted endocytosis of photo-converted PIN2 from the
PM. These analyses identify a specific effect of NAA and IAA on PIN2 endocytosis,
thus contributing to its\r\npolarity maintenance and furthermore illustrate that
high auxin levels have nonspecific effects on trafficking and endomembrane compartments. "
acknowledged_ssus:
- _id: M-Shop
- _id: Bio
acknowledgement: 'We thank Ivan Kulik for developing the Chip’n’Dale apparatus with
Lanxin Li; the IST machine shop and the Bioimaging facility for their excellent
support; Matouš Glanc and Matyáš Fendrych for their valuable discussions and help;
Barbara Casillas-Perez for her help with statistics. This project has received funding
from the European Research Council (ERC) under the European Union''s Horizon 2020
research and innovation program (grant agreement No 742985). A.J. is supported by
funding from the Austrian Science Fund (FWF): I3630B25 to J.F. '
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Madhumitha
full_name: Narasimhan, Madhumitha
id: 44BF24D0-F248-11E8-B48F-1D18A9856A87
last_name: Narasimhan
orcid: 0000-0002-8600-0671
- first_name: Michelle C
full_name: Gallei, Michelle C
id: 35A03822-F248-11E8-B48F-1D18A9856A87
last_name: Gallei
orcid: 0000-0003-1286-7368
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: Inge
full_name: Verstraeten, Inge
id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
last_name: Verstraeten
orcid: 0000-0001-7241-2328
- first_name: Lanxin
full_name: Li, Lanxin
id: 367EF8FA-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0002-5607-272X
- first_name: Lesia
full_name: Rodriguez Solovey, Lesia
id: 3922B506-F248-11E8-B48F-1D18A9856A87
last_name: Rodriguez Solovey
orcid: 0000-0002-7244-7237
- first_name: Huibin
full_name: Han, Huibin
id: 31435098-F248-11E8-B48F-1D18A9856A87
last_name: Han
- first_name: E
full_name: Himschoot, E
last_name: Himschoot
- first_name: R
full_name: Wang, R
last_name: Wang
- first_name: S
full_name: Vanneste, S
last_name: Vanneste
- first_name: J
full_name: Sánchez-Simarro, J
last_name: Sánchez-Simarro
- first_name: F
full_name: Aniento, F
last_name: Aniento
- first_name: Maciek
full_name: Adamowski, Maciek
id: 45F536D2-F248-11E8-B48F-1D18A9856A87
last_name: Adamowski
orcid: 0000-0001-6463-5257
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Narasimhan M, Gallei MC, Tan S, et al. Systematic analysis of specific and
nonspecific auxin effects on endocytosis and trafficking. Plant Physiology.
2021;186(2):1122–1142. doi:10.1093/plphys/kiab134
apa: Narasimhan, M., Gallei, M. C., Tan, S., Johnson, A. J., Verstraeten, I., Li,
L., … Friml, J. (2021). Systematic analysis of specific and nonspecific auxin
effects on endocytosis and trafficking. Plant Physiology. Oxford University
Press. https://doi.org/10.1093/plphys/kiab134
chicago: Narasimhan, Madhumitha, Michelle C Gallei, Shutang Tan, Alexander J Johnson,
Inge Verstraeten, Lanxin Li, Lesia Rodriguez Solovey, et al. “Systematic Analysis
of Specific and Nonspecific Auxin Effects on Endocytosis and Trafficking.” Plant
Physiology. Oxford University Press, 2021. https://doi.org/10.1093/plphys/kiab134.
ieee: M. Narasimhan et al., “Systematic analysis of specific and nonspecific
auxin effects on endocytosis and trafficking,” Plant Physiology, vol. 186,
no. 2. Oxford University Press, pp. 1122–1142, 2021.
ista: Narasimhan M, Gallei MC, Tan S, Johnson AJ, Verstraeten I, Li L, Rodriguez
Solovey L, Han H, Himschoot E, Wang R, Vanneste S, Sánchez-Simarro J, Aniento
F, Adamowski M, Friml J. 2021. Systematic analysis of specific and nonspecific
auxin effects on endocytosis and trafficking. Plant Physiology. 186(2), 1122–1142.
mla: Narasimhan, Madhumitha, et al. “Systematic Analysis of Specific and Nonspecific
Auxin Effects on Endocytosis and Trafficking.” Plant Physiology, vol. 186,
no. 2, Oxford University Press, 2021, pp. 1122–1142, doi:10.1093/plphys/kiab134.
short: M. Narasimhan, M.C. Gallei, S. Tan, A.J. Johnson, I. Verstraeten, L. Li,
L. Rodriguez Solovey, H. Han, E. Himschoot, R. Wang, S. Vanneste, J. Sánchez-Simarro,
F. Aniento, M. Adamowski, J. Friml, Plant Physiology 186 (2021) 1122–1142.
date_created: 2021-03-26T12:08:38Z
date_published: 2021-06-01T00:00:00Z
date_updated: 2024-03-27T23:30:43Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1093/plphys/kiab134
ec_funded: 1
external_id:
isi:
- '000671555900031'
pmid:
- '33734402'
file:
- access_level: open_access
checksum: 532bb9469d3b665907f06df8c383eade
content_type: application/pdf
creator: cziletti
date_created: 2021-11-11T15:07:51Z
date_updated: 2021-11-11T15:07:51Z
file_id: '10273'
file_name: 2021_PlantPhysio_Narasimhan.pdf
file_size: 2289127
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has_accepted_license: '1'
intvolume: ' 186'
isi: 1
issue: '2'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1122–1142
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
publication: Plant Physiology
publication_identifier:
eissn:
- 1532-2548
issn:
- 0032-0889
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: 10.1093/plphys/kiab380
record:
- id: '11626'
relation: dissertation_contains
status: public
- id: '10083'
relation: dissertation_contains
status: public
status: public
title: Systematic analysis of specific and nonspecific auxin effects on endocytosis
and trafficking
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 186
year: '2021'
...
---
_id: '10083'
abstract:
- lang: eng
text: "Plant motions occur across a wide spectrum of timescales, ranging from seed
dispersal through bursting (milliseconds) and stomatal opening (minutes) to long-term
adaptation of gross architecture. Relatively fast motions include water-driven
growth as exemplified by root cell expansion under abiotic/biotic stresses or
during gravitropism. A showcase is a root growth inhibition in 30 seconds triggered
by the phytohormone auxin. However, the cellular and molecular mechanisms are
still largely unknown. This thesis covers the studies about this topic as follows.
By taking advantage of microfluidics combined with live imaging, pharmaceutical
tools, and transgenic lines, we examined the kinetics of and causal relationship
among various auxininduced rapid cellular changes in root growth, apoplastic pH,
cytosolic Ca2+, cortical microtubule (CMT) orientation, and vacuolar morphology.
We revealed that CMT reorientation and vacuolar constriction are the consequence
of growth itself instead of responding directly to auxin. In contrast, auxin induces
apoplast alkalinization to rapidly inhibit root growth in 30 seconds. This auxin-triggered
apoplast alkalinization results from rapid H+- influx that is contributed by Ca2+
inward channel CYCLIC NUCLEOTIDE-GATED CHANNEL 14 (CNGC14)-dependent Ca2+ signaling.
To dissect which auxin signaling mediates the rapid apoplast alkalinization, we\r\ncombined
microfluidics and genetic engineering to verify that TIR1/AFB receptors conduct
a non-transcriptional regulation on Ca2+ and H+ -influx. This non-canonical pathway
is mostly mediated by the cytosolic portion of TIR1/AFB. On the other hand, we
uncovered, using biochemical and phospho-proteomic analysis, that auxin cell surface
signaling component TRANSMEMBRANE KINASE 1 (TMK1) plays a negative role during
auxin-trigger apoplast\r\nalkalinization and root growth inhibition through directly
activating PM H+ -ATPases. Therefore, we discovered that PM H+ -ATPases counteract
instead of mediate the auxintriggered rapid H+ -influx, and that TIR1/AFB and
TMK1 regulate root growth antagonistically. This opposite effect of TIR1/AFB and
TMK1 is consistent during auxin-induced hypocotyl elongation, leading us to explore
the relation of two signaling pathways. Assisted with biochemistry and fluorescent
imaging, we verified for the first time that TIR1/AFB and TMK1 can interact with
each other. The ability of TIR1/AFB binding to membrane lipid provides a basis
for the interaction of plasma membrane- and cytosol-localized proteins.\r\nBesides,
transgenic analysis combined with genetic engineering and biochemistry showed
that vi\r\nthey do function in the same pathway. Particularly, auxin-induced
TMK1 increase is TIR1/AFB dependent, suggesting TIR1/AFB regulation on TMK1. Conversely,
TMK1 also regulates TIR1/AFB protein levels and thus auxin canonical signaling.
To follow the study of rapid growth regulation, we analyzed another rapid growth
regulator, signaling peptide RALF1. We showed that RALF1 also triggers a rapid
and reversible growth inhibition caused by H + influx, highly resembling but not
dependent on auxin. Besides, RALF1 promotes auxin biosynthesis by increasing expression
of auxin biosynthesis enzyme YUCCAs and thus induces auxin signaling in ca. 1
hour, contributing to the sustained RALF1-triggered growth inhibition. These studies
collectively contribute to understanding rapid regulation on plant cell\r\ngrowth,
novel auxin signaling pathway as well as auxin-peptide crosstalk. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Lanxin
full_name: Li, Lanxin
last_name: Li
citation:
ama: Li L. Rapid cell growth regulation in Arabidopsis. 2021. doi:10.15479/at:ista:10083
apa: Li, L. (2021). Rapid cell growth regulation in Arabidopsis. Institute
of Science and Technology Austria. https://doi.org/10.15479/at:ista:10083
chicago: Li, Lanxin. “Rapid Cell Growth Regulation in Arabidopsis.” Institute of
Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:10083.
ieee: L. Li, “Rapid cell growth regulation in Arabidopsis,” Institute of Science
and Technology Austria, 2021.
ista: Li L. 2021. Rapid cell growth regulation in Arabidopsis. Institute of Science
and Technology Austria.
mla: Li, Lanxin. Rapid Cell Growth Regulation in Arabidopsis. Institute of
Science and Technology Austria, 2021, doi:10.15479/at:ista:10083.
short: L. Li, Rapid Cell Growth Regulation in Arabidopsis, Institute of Science
and Technology Austria, 2021.
date_created: 2021-10-04T13:33:10Z
date_published: 2021-10-06T00:00:00Z
date_updated: 2023-10-31T19:30:02Z
day: '06'
ddc:
- '575'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JiFr
doi: 10.15479/at:ista:10083
ec_funded: 1
file:
- access_level: open_access
checksum: 3b2f55b3b8ae05337a0dcc1cd8595b10
content_type: application/pdf
creator: cchlebak
date_created: 2021-10-14T08:00:07Z
date_updated: 2022-12-20T23:30:03Z
embargo: 2022-10-14
file_id: '10138'
file_name: 0._IST_Austria_Thesis_Lanxin_Li_1014_pdftron.pdf
file_size: 8616142
relation: main_file
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checksum: f23ed258ca894f6aabf58b0c128bf242
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: cchlebak
date_created: 2021-10-14T08:00:13Z
date_updated: 2022-12-20T23:30:03Z
embargo_to: open_access
file_id: '10139'
file_name: 0._IST_Austria_Thesis_Lanxin_Li_1014.docx
file_size: 15058499
relation: source_file
file_date_updated: 2022-12-20T23:30:03Z
has_accepted_license: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 26B4D67E-B435-11E9-9278-68D0E5697425
grant_number: '25351'
name: 'A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated
Rapid Growth Inhibition in Arabidopsis Root'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '442'
relation: part_of_dissertation
status: public
- id: '8931'
relation: part_of_dissertation
status: public
- id: '9287'
relation: part_of_dissertation
status: public
- id: '8283'
relation: part_of_dissertation
status: public
- id: '8986'
relation: part_of_dissertation
status: public
- id: '6627'
relation: part_of_dissertation
status: public
- id: '10095'
relation: part_of_dissertation
status: public
- id: '10015'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
title: Rapid cell growth regulation in Arabidopsis
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '10015'
abstract:
- lang: eng
text: "Auxin plays a dual role in growth regulation and, depending on the tissue
and concentration of the hormone, it can either promote or inhibit division and
expansion processes in plants. Recent studies have revealed that, beyond transcriptional
reprogramming, alternative auxincontrolled mechanisms regulate root growth. Here,
we explored the impact of different concentrations of the synthetic auxin NAA
that establish growth-promoting and -repressing conditions on the root tip proteome
and phosphoproteome, generating a unique resource. From the phosphoproteome data,
we pinpointed (novel) growth regulators, such as the RALF34-THE1 module. Our results,
together with previously published studies, suggest that auxin, H+-ATPases, cell
wall modifications and cell wall sensing receptor-like kinases are tightly embedded
in a pathway regulating cell elongation. Furthermore, our study assigned a novel
role to MKK2 as a regulator of primary root growth and a (potential) regulator
of auxin biosynthesis and signalling, and suggests the importance of the MKK2\r\nThr31
phosphorylation site for growth regulation in the Arabidopsis root tip."
acknowledgement: We thank the Nottingham Stock Centre for seeds, Frank Van Breusegem
for the phb3 mutant, and Herman Höfte for the the1 mutant. Open Access Funding by
the Austrian Science Fund (FWF).
alternative_title:
- Protein Phosphorylation and Cell Signaling in Plants
article_number: '1665 '
article_processing_charge: Yes
article_type: original
author:
- first_name: N
full_name: Nikonorova, N
last_name: Nikonorova
- first_name: E
full_name: Murphy, E
last_name: Murphy
- first_name: CF
full_name: Fonseca de Lima, CF
last_name: Fonseca de Lima
- first_name: S
full_name: Zhu, S
last_name: Zhu
- first_name: B
full_name: van de Cotte, B
last_name: van de Cotte
- first_name: LD
full_name: Vu, LD
last_name: Vu
- first_name: D
full_name: Balcerowicz, D
last_name: Balcerowicz
- first_name: Lanxin
full_name: Li, Lanxin
id: 367EF8FA-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0002-5607-272X
- first_name: X
full_name: Kong, X
last_name: Kong
- first_name: G
full_name: De Rop, G
last_name: De Rop
- first_name: T
full_name: Beeckman, T
last_name: Beeckman
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: K
full_name: Vissenberg, K
last_name: Vissenberg
- first_name: PC
full_name: Morris, PC
last_name: Morris
- first_name: Z
full_name: Ding, Z
last_name: Ding
- first_name: I
full_name: De Smet, I
last_name: De Smet
citation:
ama: Nikonorova N, Murphy E, Fonseca de Lima C, et al. The Arabidopsis root tip
(phospho)proteomes at growth-promoting versus growth-repressing conditions reveal
novel root growth regulators. Cells. 2021;10. doi:10.3390/cells10071665
apa: Nikonorova, N., Murphy, E., Fonseca de Lima, C., Zhu, S., van de Cotte, B.,
Vu, L., … De Smet, I. (2021). The Arabidopsis root tip (phospho)proteomes at growth-promoting
versus growth-repressing conditions reveal novel root growth regulators. Cells.
MDPI. https://doi.org/10.3390/cells10071665
chicago: Nikonorova, N, E Murphy, CF Fonseca de Lima, S Zhu, B van de Cotte, LD
Vu, D Balcerowicz, et al. “The Arabidopsis Root Tip (Phospho)Proteomes at Growth-Promoting
versus Growth-Repressing Conditions Reveal Novel Root Growth Regulators.” Cells.
MDPI, 2021. https://doi.org/10.3390/cells10071665.
ieee: N. Nikonorova et al., “The Arabidopsis root tip (phospho)proteomes
at growth-promoting versus growth-repressing conditions reveal novel root growth
regulators,” Cells, vol. 10. MDPI, 2021.
ista: Nikonorova N, Murphy E, Fonseca de Lima C, Zhu S, van de Cotte B, Vu L, Balcerowicz
D, Li L, Kong X, De Rop G, Beeckman T, Friml J, Vissenberg K, Morris P, Ding Z,
De Smet I. 2021. The Arabidopsis root tip (phospho)proteomes at growth-promoting
versus growth-repressing conditions reveal novel root growth regulators. Cells.
10, 1665.
mla: Nikonorova, N., et al. “The Arabidopsis Root Tip (Phospho)Proteomes at Growth-Promoting
versus Growth-Repressing Conditions Reveal Novel Root Growth Regulators.” Cells,
vol. 10, 1665, MDPI, 2021, doi:10.3390/cells10071665.
short: N. Nikonorova, E. Murphy, C. Fonseca de Lima, S. Zhu, B. van de Cotte, L.
Vu, D. Balcerowicz, L. Li, X. Kong, G. De Rop, T. Beeckman, J. Friml, K. Vissenberg,
P. Morris, Z. Ding, I. De Smet, Cells 10 (2021).
date_created: 2021-09-14T11:36:20Z
date_published: 2021-07-02T00:00:00Z
date_updated: 2024-03-27T23:30:43Z
day: '02'
ddc:
- '575'
department:
- _id: JiFr
doi: 10.3390/cells10071665
ec_funded: 1
external_id:
isi:
- '000676604700001'
pmid:
- '34359847'
file:
- access_level: open_access
checksum: 2a9f534b9c2200e72e2cde95afaf4eed
content_type: application/pdf
creator: cchlebak
date_created: 2021-09-16T09:07:06Z
date_updated: 2021-09-16T09:07:06Z
file_id: '10021'
file_name: 2021_Cells_Nikonorova.pdf
file_size: 2667848
relation: main_file
success: 1
file_date_updated: 2021-09-16T09:07:06Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
keyword:
- primary root
- (phospho)proteomics
- auxin
- (receptor) kinase
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 3AC91DDA-15DF-11EA-824D-93A3E7B544D1
call_identifier: FWF
name: FWF Open Access Fund
publication: Cells
publication_identifier:
issn:
- 2073-4409
publication_status: published
publisher: MDPI
quality_controlled: '1'
related_material:
record:
- id: '10083'
relation: dissertation_contains
status: public
status: public
title: The Arabidopsis root tip (phospho)proteomes at growth-promoting versus growth-repressing
conditions reveal novel root growth regulators
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2021'
...
---
_id: '10095'
abstract:
- lang: eng
text: Growth regulation tailors plant development to its environment. A showcase
is response to gravity, where shoots bend up and roots down1. This paradox is
based on opposite effects of the phytohormone auxin, which promotes cell expansion
in shoots, while inhibiting it in roots via a yet unknown cellular mechanism2.
Here, by combining microfluidics, live imaging, genetic engineering and phospho-proteomics
in Arabidopsis thaliana, we advance our understanding how auxin inhibits root
growth. We show that auxin activates two distinct, antagonistically acting signalling
pathways that converge on the rapid regulation of the apoplastic pH, a causative
growth determinant. Cell surface-based TRANSMEMBRANE KINASE1 (TMK1) interacts
with and mediates phosphorylation and activation of plasma membrane H+-ATPases
for apoplast acidification, while intracellular canonical auxin signalling promotes
net cellular H+-influx, causing apoplast alkalinisation. The simultaneous activation
of these two counteracting mechanisms poises the root for a rapid, fine-tuned
growth modulation while navigating complex soil environment.
acknowledged_ssus:
- _id: LifeSc
- _id: M-Shop
- _id: Bio
acknowledgement: We thank Nataliia Gnyliukh and Lukas Hörmayer for technical assistance
and Nadine Paris for sharing PM-Cyto seeds. We gratefully acknowledge Life Science,
Machine Shop and Bioimaging Facilities of IST Austria. This project has received
funding from the European Research Council Advanced Grant (ETAP-742985) and the
Austrian Science Fund (FWF) I 3630-B25 to J.F., the National Institutes of Health
(GM067203) to W.M.G., the Netherlands Organization for Scientific Research (NWO;
VIDI-864.13.001.), the Research Foundation-Flanders (FWO; Odysseus II G0D0515N)
and a European Research Council Starting Grant (TORPEDO-714055) to W.S. and B.D.R.,
the VICI grant (865.14.001) from the Netherlands Organization for Scientific Research
to M.R and D.W., the Australian Research Council and China National Distinguished
Expert Project (WQ20174400441) to S.S., the MEXT/JSPS KAKENHI to K.T. (20K06685)
and T.K. (20H05687 and 20H05910), the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 665385
and the DOC Fellowship of the Austrian Academy of Sciences to L.L., the China Scholarship
Council to J.C.
article_number: '266395'
article_processing_charge: No
author:
- first_name: Lanxin
full_name: Li, Lanxin
id: 367EF8FA-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0002-5607-272X
- first_name: Inge
full_name: Verstraeten, Inge
id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
last_name: Verstraeten
orcid: 0000-0001-7241-2328
- first_name: Mark
full_name: Roosjen, Mark
last_name: Roosjen
- first_name: Koji
full_name: Takahashi, Koji
last_name: Takahashi
- first_name: Lesia
full_name: Rodriguez Solovey, Lesia
id: 3922B506-F248-11E8-B48F-1D18A9856A87
last_name: Rodriguez Solovey
orcid: 0000-0002-7244-7237
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Jian
full_name: Chen, Jian
last_name: Chen
- first_name: Lana
full_name: Shabala, Lana
last_name: Shabala
- first_name: Wouter
full_name: Smet, Wouter
last_name: Smet
- first_name: Hong
full_name: Ren, Hong
last_name: Ren
- first_name: Steffen
full_name: Vanneste, Steffen
last_name: Vanneste
- first_name: Sergey
full_name: Shabala, Sergey
last_name: Shabala
- first_name: Bert
full_name: De Rybel, Bert
last_name: De Rybel
- first_name: Dolf
full_name: Weijers, Dolf
last_name: Weijers
- first_name: Toshinori
full_name: Kinoshita, Toshinori
last_name: Kinoshita
- first_name: William M.
full_name: Gray, William M.
last_name: Gray
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Li L, Verstraeten I, Roosjen M, et al. Cell surface and intracellular auxin
signalling for H+-fluxes in root growth. Research Square. doi:10.21203/rs.3.rs-266395/v3
apa: Li, L., Verstraeten, I., Roosjen, M., Takahashi, K., Rodriguez Solovey, L.,
Merrin, J., … Friml, J. (n.d.). Cell surface and intracellular auxin signalling
for H+-fluxes in root growth. Research Square. https://doi.org/10.21203/rs.3.rs-266395/v3
chicago: Li, Lanxin, Inge Verstraeten, Mark Roosjen, Koji Takahashi, Lesia Rodriguez
Solovey, Jack Merrin, Jian Chen, et al. “Cell Surface and Intracellular Auxin
Signalling for H+-Fluxes in Root Growth.” Research Square, n.d. https://doi.org/10.21203/rs.3.rs-266395/v3.
ieee: L. Li et al., “Cell surface and intracellular auxin signalling for
H+-fluxes in root growth,” Research Square. .
ista: Li L, Verstraeten I, Roosjen M, Takahashi K, Rodriguez Solovey L, Merrin J,
Chen J, Shabala L, Smet W, Ren H, Vanneste S, Shabala S, De Rybel B, Weijers D,
Kinoshita T, Gray WM, Friml J. Cell surface and intracellular auxin signalling
for H+-fluxes in root growth. Research Square, 266395.
mla: Li, Lanxin, et al. “Cell Surface and Intracellular Auxin Signalling for H+-Fluxes
in Root Growth.” Research Square, 266395, doi:10.21203/rs.3.rs-266395/v3.
short: L. Li, I. Verstraeten, M. Roosjen, K. Takahashi, L. Rodriguez Solovey, J.
Merrin, J. Chen, L. Shabala, W. Smet, H. Ren, S. Vanneste, S. Shabala, B. De Rybel,
D. Weijers, T. Kinoshita, W.M. Gray, J. Friml, Research Square (n.d.).
date_created: 2021-10-06T08:56:22Z
date_published: 2021-09-09T00:00:00Z
date_updated: 2024-03-27T23:30:43Z
day: '09'
department:
- _id: JiFr
- _id: NanoFab
doi: 10.21203/rs.3.rs-266395/v3
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.doi.org/10.21203/rs.3.rs-266395/v3
month: '09'
oa: 1
oa_version: Preprint
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
- _id: 26B4D67E-B435-11E9-9278-68D0E5697425
grant_number: '25351'
name: 'A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated
Rapid Growth Inhibition in Arabidopsis Root'
publication: Research Square
publication_identifier:
issn:
- 2693-5015
publication_status: accepted
related_material:
record:
- id: '10223'
relation: later_version
status: public
- id: '10083'
relation: dissertation_contains
status: public
status: public
title: Cell surface and intracellular auxin signalling for H+-fluxes in root growth
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '10293'
abstract:
- lang: eng
text: "Indirect reciprocity in evolutionary game theory is a prominent mechanism
for explaining the evolution of cooperation among unrelated individuals. In contrast
to direct reciprocity, which is based on individuals meeting repeatedly, and conditionally
cooperating by using their own experiences, indirect reciprocity is based on individuals’
reputations. If a player helps another, this increases the helper’s public standing,
benefitting them in the future. This lets cooperation in the population emerge
without individuals having to meet more than once. While the two modes of reciprocity
are intertwined, they are difficult to compare. Thus, they are usually studied
in isolation. Direct reciprocity can maintain cooperation with simple strategies,
and is robust against noise even when players do not remember more\r\nthan their
partner’s last action. Meanwhile, indirect reciprocity requires its successful
strategies, or social norms, to be more complex. Exhaustive search previously
identified eight such norms, called the “leading eight”, which excel at maintaining
cooperation. However, as the first result of this thesis, we show that the leading
eight break down once we remove the fundamental assumption that information is
synchronized and public, such that everyone agrees on reputations. Once we consider
a more realistic scenario of imperfect information, where reputations are private,
and individuals occasionally misinterpret or miss observations, the leading eight
do not promote cooperation anymore. Instead, minor initial disagreements can proliferate,
fragmenting populations into subgroups. In a next step, we consider ways to mitigate
this issue. We first explore whether introducing “generosity” can stabilize cooperation
when players use the leading eight strategies in noisy environments. This approach
of modifying strategies to include probabilistic elements for coping with errors
is known to work well in direct reciprocity. However, as we show here, it fails
for the more complex norms of indirect reciprocity. Imperfect information still
prevents cooperation from evolving. On the other hand, we succeeded to show in
this thesis that modifying the leading eight to use “quantitative assessment”,
i.e. tracking reputation scores on a scale beyond good and bad, and making overall
judgments of others based on a threshold, is highly successful, even when noise
increases in the environment. Cooperation can flourish when reputations\r\nare
more nuanced, and players have a broader understanding what it means to be “good.”
Finally, we present a single theoretical framework that unites the two modes of
reciprocity despite their differences. Within this framework, we identify a novel
simple and successful strategy for indirect reciprocity, which can cope with noisy
environments and has an analogue in direct reciprocity. We can also analyze decision
making when different sources of information are available. Our results help highlight
that for sustaining cooperation, already the most simple rules of reciprocity
can be sufficient."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Laura
full_name: Schmid, Laura
id: 38B437DE-F248-11E8-B48F-1D18A9856A87
last_name: Schmid
orcid: 0000-0002-6978-7329
citation:
ama: Schmid L. Evolution of cooperation via (in)direct reciprocity under imperfect
information. 2021. doi:10.15479/at:ista:10293
apa: Schmid, L. (2021). Evolution of cooperation via (in)direct reciprocity under
imperfect information. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:10293
chicago: Schmid, Laura. “Evolution of Cooperation via (in)Direct Reciprocity under
Imperfect Information.” Institute of Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:10293.
ieee: L. Schmid, “Evolution of cooperation via (in)direct reciprocity under imperfect
information,” Institute of Science and Technology Austria, 2021.
ista: Schmid L. 2021. Evolution of cooperation via (in)direct reciprocity under
imperfect information. Institute of Science and Technology Austria.
mla: Schmid, Laura. Evolution of Cooperation via (in)Direct Reciprocity under
Imperfect Information. Institute of Science and Technology Austria, 2021,
doi:10.15479/at:ista:10293.
short: L. Schmid, Evolution of Cooperation via (in)Direct Reciprocity under Imperfect
Information, Institute of Science and Technology Austria, 2021.
date_created: 2021-11-15T17:12:57Z
date_published: 2021-11-17T00:00:00Z
date_updated: 2023-11-07T08:28:29Z
day: '17'
ddc:
- '519'
- '576'
degree_awarded: PhD
department:
- _id: GradSch
- _id: KrCh
doi: 10.15479/at:ista:10293
ec_funded: 1
file:
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checksum: 86a05b430756ca12ae8107b6e6f3c1e5
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creator: lschmid
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date_updated: 2022-12-20T23:30:08Z
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language:
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month: '11'
oa: 1
oa_version: Published Version
page: '171'
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9997'
relation: part_of_dissertation
status: public
- id: '2'
relation: part_of_dissertation
status: public
- id: '9402'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
title: Evolution of cooperation via (in)direct reciprocity under imperfect information
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '9997'
abstract:
- lang: eng
text: Indirect reciprocity is a mechanism for the evolution of cooperation based
on social norms. This mechanism requires that individuals in a population observe
and judge each other’s behaviors. Individuals with a good reputation are more
likely to receive help from others. Previous work suggests that indirect reciprocity
is only effective when all relevant information is reliable and publicly available.
Otherwise, individuals may disagree on how to assess others, even if they all
apply the same social norm. Such disagreements can lead to a breakdown of cooperation.
Here we explore whether the predominantly studied ‘leading eight’ social norms
of indirect reciprocity can be made more robust by equipping them with an element
of generosity. To this end, we distinguish between two kinds of generosity. According
to assessment generosity, individuals occasionally assign a good reputation to
group members who would usually be regarded as bad. According to action generosity,
individuals occasionally cooperate with group members with whom they would usually
defect. Using individual-based simulations, we show that the two kinds of generosity
have a very different effect on the resulting reputation dynamics. Assessment
generosity tends to add to the overall noise and allows defectors to invade. In
contrast, a limited amount of action generosity can be beneficial in a few cases.
However, even when action generosity is beneficial, the respective simulations
do not result in full cooperation. Our results suggest that while generosity can
favor cooperation when individuals use the most simple strategies of reciprocity,
it is disadvantageous when individuals use more complex social norms.
acknowledgement: 'This work was supported by the European Research Council CoG 863818
(ForM-SMArt) (to K.C.) and the European Research Council Starting Grant 850529:
E-DIRECT (to C.H.). L.S. received additional partial support by the Austrian Science
Fund (FWF) under Grant Z211-N23 (Wittgenstein Award).'
article_number: '17443'
article_processing_charge: Yes
article_type: original
author:
- first_name: Laura
full_name: Schmid, Laura
id: 38B437DE-F248-11E8-B48F-1D18A9856A87
last_name: Schmid
orcid: 0000-0002-6978-7329
- first_name: Pouya
full_name: Shati, Pouya
last_name: Shati
- first_name: Christian
full_name: Hilbe, Christian
last_name: Hilbe
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
citation:
ama: Schmid L, Shati P, Hilbe C, Chatterjee K. The evolution of indirect reciprocity
under action and assessment generosity. Scientific Reports. 2021;11(1).
doi:10.1038/s41598-021-96932-1
apa: Schmid, L., Shati, P., Hilbe, C., & Chatterjee, K. (2021). The evolution
of indirect reciprocity under action and assessment generosity. Scientific
Reports. Springer Nature. https://doi.org/10.1038/s41598-021-96932-1
chicago: Schmid, Laura, Pouya Shati, Christian Hilbe, and Krishnendu Chatterjee.
“The Evolution of Indirect Reciprocity under Action and Assessment Generosity.”
Scientific Reports. Springer Nature, 2021. https://doi.org/10.1038/s41598-021-96932-1.
ieee: L. Schmid, P. Shati, C. Hilbe, and K. Chatterjee, “The evolution of indirect
reciprocity under action and assessment generosity,” Scientific Reports,
vol. 11, no. 1. Springer Nature, 2021.
ista: Schmid L, Shati P, Hilbe C, Chatterjee K. 2021. The evolution of indirect
reciprocity under action and assessment generosity. Scientific Reports. 11(1),
17443.
mla: Schmid, Laura, et al. “The Evolution of Indirect Reciprocity under Action and
Assessment Generosity.” Scientific Reports, vol. 11, no. 1, 17443, Springer
Nature, 2021, doi:10.1038/s41598-021-96932-1.
short: L. Schmid, P. Shati, C. Hilbe, K. Chatterjee, Scientific Reports 11 (2021).
date_created: 2021-09-11T16:22:02Z
date_published: 2021-08-31T00:00:00Z
date_updated: 2024-03-27T23:30:44Z
day: '31'
ddc:
- '003'
department:
- _id: GradSch
- _id: KrCh
doi: 10.1038/s41598-021-96932-1
ec_funded: 1
external_id:
isi:
- '000692406400018'
pmid:
- '34465830'
file:
- access_level: open_access
checksum: 19df8816cf958b272b85841565c73182
content_type: application/pdf
creator: cchlebak
date_created: 2021-09-13T10:31:21Z
date_updated: 2021-09-13T10:31:21Z
file_id: '10006'
file_name: 2021_ScientificReports_Schmid.pdf
file_size: 2424943
relation: main_file
success: 1
file_date_updated: 2021-09-13T10:31:21Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '1'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: Scientific Reports
publication_identifier:
eissn:
- 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '10293'
relation: dissertation_contains
status: public
status: public
title: The evolution of indirect reciprocity under action and assessment generosity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2021'
...
---
_id: '9402'
abstract:
- lang: eng
text: Direct and indirect reciprocity are key mechanisms for the evolution of cooperation.
Direct reciprocity means that individuals use their own experience to decide whether
to cooperate with another person. Indirect reciprocity means that they also consider
the experiences of others. Although these two mechanisms are intertwined, they
are typically studied in isolation. Here, we introduce a mathematical framework
that allows us to explore both kinds of reciprocity simultaneously. We show that
the well-known ‘generous tit-for-tat’ strategy of direct reciprocity has a natural
analogue in indirect reciprocity, which we call ‘generous scoring’. Using an equilibrium
analysis, we characterize under which conditions either of the two strategies
can maintain cooperation. With simulations, we additionally explore which kind
of reciprocity evolves when members of a population engage in social learning
to adapt to their environment. Our results draw unexpected connections between
direct and indirect reciprocity while highlighting important differences regarding
their evolvability.
acknowledgement: 'This work was supported by the European Research Council CoG 863818
(ForM-SMArt) (to K.C.), the European Research Council Start Grant 279307: Graph
Games (to K.C.), and the European Research Council Starting Grant 850529: E-DIRECT
(to C.H.). The funders had no role in study design, data collection and analysis,
decision to publish or preparation of the manuscript.'
article_processing_charge: No
article_type: original
author:
- first_name: Laura
full_name: Schmid, Laura
id: 38B437DE-F248-11E8-B48F-1D18A9856A87
last_name: Schmid
orcid: 0000-0002-6978-7329
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Christian
full_name: Hilbe, Christian
id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
last_name: Hilbe
orcid: 0000-0001-5116-955X
- first_name: Martin A.
full_name: Nowak, Martin A.
last_name: Nowak
citation:
ama: Schmid L, Chatterjee K, Hilbe C, Nowak MA. A unified framework of direct and
indirect reciprocity. Nature Human Behaviour. 2021;5(10):1292–1302. doi:10.1038/s41562-021-01114-8
apa: Schmid, L., Chatterjee, K., Hilbe, C., & Nowak, M. A. (2021). A unified
framework of direct and indirect reciprocity. Nature Human Behaviour. Springer
Nature. https://doi.org/10.1038/s41562-021-01114-8
chicago: Schmid, Laura, Krishnendu Chatterjee, Christian Hilbe, and Martin A. Nowak.
“A Unified Framework of Direct and Indirect Reciprocity.” Nature Human Behaviour.
Springer Nature, 2021. https://doi.org/10.1038/s41562-021-01114-8.
ieee: L. Schmid, K. Chatterjee, C. Hilbe, and M. A. Nowak, “A unified framework
of direct and indirect reciprocity,” Nature Human Behaviour, vol. 5, no.
10. Springer Nature, pp. 1292–1302, 2021.
ista: Schmid L, Chatterjee K, Hilbe C, Nowak MA. 2021. A unified framework of direct
and indirect reciprocity. Nature Human Behaviour. 5(10), 1292–1302.
mla: Schmid, Laura, et al. “A Unified Framework of Direct and Indirect Reciprocity.”
Nature Human Behaviour, vol. 5, no. 10, Springer Nature, 2021, pp. 1292–1302,
doi:10.1038/s41562-021-01114-8.
short: L. Schmid, K. Chatterjee, C. Hilbe, M.A. Nowak, Nature Human Behaviour 5
(2021) 1292–1302.
date_created: 2021-05-18T16:56:57Z
date_published: 2021-05-13T00:00:00Z
date_updated: 2024-03-27T23:30:44Z
day: '13'
ddc:
- '000'
department:
- _id: KrCh
- _id: GradSch
doi: 10.1038/s41562-021-01114-8
ec_funded: 1
external_id:
isi:
- '000650304000002'
pmid:
- '33986519'
file:
- access_level: open_access
checksum: 34f55e173f90dc1dab731063458ac780
content_type: application/pdf
creator: dernst
date_created: 2023-11-07T08:27:23Z
date_updated: 2023-11-07T08:27:23Z
file_id: '14496'
file_name: 2021_NatureHumanBehaviour_Schmid_accepted.pdf
file_size: 5232761
relation: main_file
success: 1
file_date_updated: 2023-11-07T08:27:23Z
has_accepted_license: '1'
intvolume: ' 5'
isi: 1
issue: '10'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 1292–1302
pmid: 1
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
publication: Nature Human Behaviour
publication_identifier:
eissn:
- 2397-3374
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/the-emergence-of-cooperation/
record:
- id: '10293'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: A unified framework of direct and indirect reciprocity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2021'
...
---
_id: '9817'
abstract:
- lang: eng
text: Elastic bending of initially flat slender elements allows the realization
and economic fabrication of intriguing curved shapes. In this work, we derive
an intuitive but rigorous geometric characterization of the design space of plane
elastic rods with variable stiffness. It enables designers to determine which
shapes are physically viable with active bending by visual inspection alone. Building
on these insights, we propose a method for efficiently designing the geometry
of a flat elastic rod that realizes a target equilibrium curve, which only requires
solving a linear program. We implement this method in an interactive computational
design tool that gives feedback about the feasibility of a design, and computes
the geometry of the structural elements necessary to realize it within an instant.
The tool also offers an iterative optimization routine that improves the fabricability
of a model while modifying it as little as possible. In addition, we use our geometric
characterization to derive an algorithm for analyzing and recovering the stability
of elastic curves that would otherwise snap out of their unstable equilibrium
shapes by buckling. We show the efficacy of our approach by designing and manufacturing
several physical models that are assembled from flat elements.
acknowledgement: "We thank the anonymous reviewers for their generous feedback, and
Michal Piovarči for his help in producing the supplemental video. This project has
received funding from the European Research Council (ERC) under the European Union’s
Horizon 2020 research and innovation programme (grant agreement No 715767).\r\n"
article_number: '126'
article_processing_charge: No
article_type: original
author:
- first_name: Christian
full_name: Hafner, Christian
id: 400429CC-F248-11E8-B48F-1D18A9856A87
last_name: Hafner
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
citation:
ama: Hafner C, Bickel B. The design space of plane elastic curves. ACM Transactions
on Graphics. 2021;40(4). doi:10.1145/3450626.3459800
apa: 'Hafner, C., & Bickel, B. (2021). The design space of plane elastic curves.
ACM Transactions on Graphics. Virtual: Association for Computing Machinery.
https://doi.org/10.1145/3450626.3459800'
chicago: Hafner, Christian, and Bernd Bickel. “The Design Space of Plane Elastic
Curves.” ACM Transactions on Graphics. Association for Computing Machinery,
2021. https://doi.org/10.1145/3450626.3459800.
ieee: C. Hafner and B. Bickel, “The design space of plane elastic curves,” ACM
Transactions on Graphics, vol. 40, no. 4. Association for Computing Machinery,
2021.
ista: Hafner C, Bickel B. 2021. The design space of plane elastic curves. ACM Transactions
on Graphics. 40(4), 126.
mla: Hafner, Christian, and Bernd Bickel. “The Design Space of Plane Elastic Curves.”
ACM Transactions on Graphics, vol. 40, no. 4, 126, Association for Computing
Machinery, 2021, doi:10.1145/3450626.3459800.
short: C. Hafner, B. Bickel, ACM Transactions on Graphics 40 (2021).
conference:
end_date: 2021-08-13
location: Virtual
name: 'SIGGRAF: Special Interest Group on Computer Graphics and Interactive Techniques'
start_date: 2021-08-09
date_created: 2021-08-08T22:01:26Z
date_published: 2021-07-19T00:00:00Z
date_updated: 2024-03-27T23:30:45Z
day: '19'
ddc:
- '516'
department:
- _id: BeBi
doi: 10.1145/3450626.3459800
ec_funded: 1
external_id:
isi:
- '000674930900091'
file:
- access_level: open_access
checksum: 7e5d08ce46b0451b3102eacd3d00f85f
content_type: application/pdf
creator: chafner
date_created: 2021-10-18T10:42:15Z
date_updated: 2021-10-18T10:42:15Z
file_id: '10150'
file_name: elastic-curves-paper.pdf
file_size: 17064290
relation: main_file
success: 1
- access_level: open_access
checksum: 0088643478be7c01a703b5b10767348f
content_type: application/pdf
creator: chafner
date_created: 2021-10-18T10:42:22Z
date_updated: 2021-10-18T10:42:22Z
file_id: '10151'
file_name: elastic-curves-supp.pdf
file_size: 547156
relation: supplementary_material
file_date_updated: 2021-10-18T10:42:22Z
has_accepted_license: '1'
intvolume: ' 40'
isi: 1
issue: '4'
keyword:
- Computing methodologies
- shape modeling
- modeling and simulation
- theory of computation
- computational geometry
- mathematics of computing
- mathematical optimization
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication: ACM Transactions on Graphics
publication_identifier:
eissn:
- 1557-7368
issn:
- 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
link:
- description: News on IST Website
relation: press_release
url: https://ist.ac.at/en/news/designing-with-elastic-structures/
record:
- id: '12897'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: The design space of plane elastic curves
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 40
year: '2021'
...
---
_id: '10135'
abstract:
- lang: eng
text: "Plants maintain the capacity to develop new organs e.g. lateral roots post-embryonically
throughout their whole life and thereby flexibly adapt to ever-changing environmental
conditions. Plant hormones auxin and cytokinin are the main regulators of the
lateral root organogenesis. Additionally to their solo activities, the interaction
between auxin and\r\ncytokinin plays crucial role in fine-tuning of lateral root
development and growth. In particular, cytokinin modulates auxin distribution
within the developing lateral root by affecting the endomembrane trafficking of
auxin transporter PIN1 and promoting its vacuolar degradation (Marhavý et al.,
2011, 2014). This effect is independent of transcription and\r\ntranslation. Therefore,
it suggests novel, non-canonical cytokinin activity occuring possibly on the posttranslational
level. Impact of cytokinin and other plant hormones on auxin transporters (including
PIN1) on the posttranslational level is described in detail in the introduction
part of this thesis in a form of a review (Semeradova et al., 2020). To gain insights
into the molecular machinery underlying cytokinin effect on the endomembrane trafficking
in the plant cell, in particular on the PIN1 degradation, we conducted two large
proteomic screens: 1) Identification of cytokinin binding proteins using\r\nchemical
proteomics. 2) Monitoring of proteomic and phosphoproteomic changes upon cytokinin
treatment. In the first screen, we identified DYNAMIN RELATED PROTEIN 2A (DRP2A).
We found that DRP2A plays a role in cytokinin regulated processes during the plant
growth and that cytokinin treatment promotes destabilization of DRP2A protein.
However, the role of DRP2A in the PIN1 degradation remains to be elucidated. In
the second screen, we found VACUOLAR PROTEIN SORTING 9A (VPS9A). VPS9a plays crucial
role in plant’s response to cytokin and in cytokinin mediated PIN1 degradation.
Altogether, we identified proteins, which bind to cytokinin and proteins that
in response to\r\ncytokinin exhibit significantly changed abundance or phosphorylation
pattern. By combining information from these two screens, we can pave our way
towards understanding of noncanonical cytokinin effects."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Hana
full_name: Semerádová, Hana
id: 42FE702E-F248-11E8-B48F-1D18A9856A87
last_name: Semerádová
citation:
ama: Semerádová H. Molecular mechanisms of the cytokinin-regulated endomembrane
trafficking to coordinate plant organogenesis. 2021. doi:10.15479/at:ista:10135
apa: Semerádová, H. (2021). Molecular mechanisms of the cytokinin-regulated endomembrane
trafficking to coordinate plant organogenesis. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:10135
chicago: Semerádová, Hana. “Molecular Mechanisms of the Cytokinin-Regulated Endomembrane
Trafficking to Coordinate Plant Organogenesis.” Institute of Science and Technology
Austria, 2021. https://doi.org/10.15479/at:ista:10135.
ieee: H. Semerádová, “Molecular mechanisms of the cytokinin-regulated endomembrane
trafficking to coordinate plant organogenesis,” Institute of Science and Technology
Austria, 2021.
ista: Semerádová H. 2021. Molecular mechanisms of the cytokinin-regulated endomembrane
trafficking to coordinate plant organogenesis. Institute of Science and Technology
Austria.
mla: Semerádová, Hana. Molecular Mechanisms of the Cytokinin-Regulated Endomembrane
Trafficking to Coordinate Plant Organogenesis. Institute of Science and Technology
Austria, 2021, doi:10.15479/at:ista:10135.
short: H. Semerádová, Molecular Mechanisms of the Cytokinin-Regulated Endomembrane
Trafficking to Coordinate Plant Organogenesis, Institute of Science and Technology
Austria, 2021.
date_created: 2021-10-13T13:42:48Z
date_published: 2021-10-13T00:00:00Z
date_updated: 2024-01-25T10:53:29Z
day: '13'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: EvBe
doi: 10.15479/at:ista:10135
file:
- access_level: closed
checksum: ce7108853e6cec6224f17cd6429b51fe
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creator: cziletti
date_created: 2021-10-27T07:45:37Z
date_updated: 2022-12-20T23:30:05Z
embargo_to: open_access
file_id: '10186'
file_name: Hana_Semeradova_Disertation_Thesis_II_Revised_3.docx
file_size: 28508629
relation: source_file
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content_type: application/pdf
creator: cziletti
date_created: 2021-10-27T07:45:57Z
date_updated: 2022-12-20T23:30:05Z
embargo: 2022-10-28
file_id: '10187'
file_name: Hana_Semeradova_Disertation_Thesis_II_Revised_3PDFA.pdf
file_size: 10623525
relation: main_file
file_date_updated: 2022-12-20T23:30:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 261821BC-B435-11E9-9278-68D0E5697425
grant_number: '24746'
name: Molecular mechanisms of the cytokinin regulated endomembrane trafficking to
coordinate plant organogenesis.
publication_identifier:
isbn:
- 978-3-99078-014-5
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9160'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
title: Molecular mechanisms of the cytokinin-regulated endomembrane trafficking to
coordinate plant organogenesis
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '9728'
abstract:
- lang: eng
text: "Most real-world flows are multiphase, yet we know little about them compared
to their single-phase counterparts. Multiphase flows are more difficult to investigate
as their dynamics occur in large parameter space and involve complex phenomena
such as preferential concentration, turbulence modulation, non-Newtonian rheology,
etc. Over the last few decades, experiments in particle-laden flows have taken
a back seat in favour of ever-improving computational resources. However, computers
are still not powerful enough to simulate a real-world fluid with millions of
finite-size particles. Experiments are essential not only because they offer a
reliable way to investigate real-world multiphase flows but also because they
serve to validate numerical studies and steer the research in a relevant direction.
In this work, we have experimentally investigated particle-laden flows in pipes,
and in particular, examined the effect of particles on the laminar-turbulent transition
and the drag scaling in turbulent flows.\r\n\r\nFor particle-laden pipe flows,
an earlier study [Matas et al., 2003] reported how the sub-critical (i.e., hysteretic)
transition that occurs via localised turbulent structures called puffs is affected
by the addition of particles. In this study, in addition to this known transition,
we found a super-critical transition to a globally fluctuating state with increasing
particle concentration. At the same time, the Newtonian-type transition via puffs
is delayed to larger Reynolds numbers. At an even higher concentration, only the
globally fluctuating state is found. The dynamics of particle-laden flows are
hence determined by two competing instabilities that give rise to three flow regimes:
Newtonian-type turbulence at low, a particle-induced globally fluctuating state
at high, and a coexistence state at intermediate concentrations.\r\n\r\nThe effect
of particles on turbulent drag is ambiguous, with studies reporting drag reduction,
no net change, and even drag increase. The ambiguity arises because, in addition
to particle concentration, particle shape, size, and density also affect the net
drag. Even similar particles might affect the flow dissimilarly in different Reynolds
number and concentration ranges. In the present study, we explored a wide range
of both Reynolds number and concentration, using spherical as well as cylindrical
particles. We found that the spherical particles do not reduce drag while the
cylindrical particles are drag-reducing within a specific Reynolds number interval.
The interval strongly depends on the particle concentration and the relative size
of the pipe and particles. Within this interval, the magnitude of drag reduction
reaches a maximum. These drag reduction maxima appear to fall onto a distinct
power-law curve irrespective of the pipe diameter and particle concentration,
and this curve can be considered as the maximum drag reduction asymptote for a
given fibre shape. Such an asymptote is well known for polymeric flows but had
not been identified for particle-laden flows prior to this work."
acknowledged_ssus:
- _id: M-Shop
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Nishchal
full_name: Agrawal, Nishchal
id: 469E6004-F248-11E8-B48F-1D18A9856A87
last_name: Agrawal
citation:
ama: Agrawal N. Transition to turbulence and drag reduction in particle-laden pipe
flows. 2021. doi:10.15479/at:ista:9728
apa: Agrawal, N. (2021). Transition to turbulence and drag reduction in particle-laden
pipe flows. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:9728
chicago: Agrawal, Nishchal. “Transition to Turbulence and Drag Reduction in Particle-Laden
Pipe Flows.” Institute of Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:9728.
ieee: N. Agrawal, “Transition to turbulence and drag reduction in particle-laden
pipe flows,” Institute of Science and Technology Austria, 2021.
ista: Agrawal N. 2021. Transition to turbulence and drag reduction in particle-laden
pipe flows. Institute of Science and Technology Austria.
mla: Agrawal, Nishchal. Transition to Turbulence and Drag Reduction in Particle-Laden
Pipe Flows. Institute of Science and Technology Austria, 2021, doi:10.15479/at:ista:9728.
short: N. Agrawal, Transition to Turbulence and Drag Reduction in Particle-Laden
Pipe Flows, Institute of Science and Technology Austria, 2021.
date_created: 2021-07-27T13:40:30Z
date_published: 2021-07-29T00:00:00Z
date_updated: 2024-02-28T13:14:39Z
day: '29'
ddc:
- '532'
degree_awarded: PhD
department:
- _id: GradSch
- _id: BjHo
doi: 10.15479/at:ista:9728
file:
- access_level: closed
checksum: 77436be3563a90435024307b1b5ee7e8
content_type: application/x-zip-compressed
creator: nagrawal
date_created: 2021-07-28T13:32:02Z
date_updated: 2022-07-29T22:30:05Z
embargo_to: open_access
file_id: '9744'
file_name: Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.zip
file_size: 22859658
relation: source_file
- access_level: open_access
checksum: 72a891d7daba85445c29b868c22575ed
content_type: application/pdf
creator: nagrawal
date_created: 2021-07-28T13:32:05Z
date_updated: 2022-07-29T22:30:05Z
embargo: 2022-07-28
file_id: '9745'
file_name: Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.pdf
file_size: 18658048
relation: main_file
file_date_updated: 2022-07-29T22:30:05Z
has_accepted_license: '1'
keyword:
- Drag Reduction
- Transition to Turbulence
- Multiphase Flows
- particle Laden Flows
- Complex Flows
- Experiments
- Fluid Dynamics
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '118'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '6189'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
title: Transition to turbulence and drag reduction in particle-laden pipe flows
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '10336'
abstract:
- lang: eng
text: Biological membranes can dramatically accelerate the aggregation of normally
soluble protein molecules into amyloid fibrils and alter the fibril morphologies,
yet the molecular mechanisms through which this accelerated nucleation takes place
are not yet understood. Here, we develop a coarse-grained model to systematically
explore the effect that the structural properties of the lipid membrane and the
nature of protein–membrane interactions have on the nucleation rates of amyloid
fibrils. We identify two physically distinct nucleation pathways—protein-rich
and lipid-rich—and quantify how the membrane fluidity and protein–membrane affinity
control the relative importance of those molecular pathways. We find that the
membrane’s susceptibility to reshaping and being incorporated into the fibrillar
aggregates is a key determinant of its ability to promote protein aggregation.
We then characterize the rates and the free-energy profile associated with this
heterogeneous nucleation process, in which the surface itself participates in
the aggregate structure. Finally, we compare quantitatively our data to experiments
on membrane-catalyzed amyloid aggregation of α-synuclein, a protein implicated
in Parkinson’s disease that predominately nucleates on membranes. More generally,
our results provide a framework for understanding macromolecular aggregation on
lipid membranes in a broad biological and biotechnological context.
acknowledgement: We thank T. C. T. Michaels for reading the manuscript. This work
was supported by the Academy of Medical Science (J.K. and A.Š.), the Cambridge Center
for Misfolding Diseases (T.P.J.K.), the Biotechnology and Biological Sciences Research
Council (T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.), the European
Research Council Grant PhysProt Agreement 337969, the Wellcome Trust (A.Š. and T.P.J.K.),
the Royal Society (A.Š.), the Medical Research Council (J.K. and A.Š.), and the
UK Materials and Molecular Modeling Hub for computational resources, which is partially
funded by Engineering and Physical Sciences Research Council Grant EP/P020194/1.
article_processing_charge: No
article_type: original
author:
- first_name: Johannes
full_name: Krausser, Johannes
last_name: Krausser
- first_name: Tuomas P. J.
full_name: Knowles, Tuomas P. J.
last_name: Knowles
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Krausser J, Knowles TPJ, Šarić A. Physical mechanisms of amyloid nucleation
on fluid membranes. Proceedings of the National Academy of Sciences. 2020;117(52):33090-33098.
doi:10.1073/pnas.2007694117
apa: Krausser, J., Knowles, T. P. J., & Šarić, A. (2020). Physical mechanisms
of amyloid nucleation on fluid membranes. Proceedings of the National Academy
of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.2007694117
chicago: Krausser, Johannes, Tuomas P. J. Knowles, and Anđela Šarić. “Physical Mechanisms
of Amyloid Nucleation on Fluid Membranes.” Proceedings of the National Academy
of Sciences. National Academy of Sciences, 2020. https://doi.org/10.1073/pnas.2007694117.
ieee: J. Krausser, T. P. J. Knowles, and A. Šarić, “Physical mechanisms of amyloid
nucleation on fluid membranes,” Proceedings of the National Academy of Sciences,
vol. 117, no. 52. National Academy of Sciences, pp. 33090–33098, 2020.
ista: Krausser J, Knowles TPJ, Šarić A. 2020. Physical mechanisms of amyloid nucleation
on fluid membranes. Proceedings of the National Academy of Sciences. 117(52),
33090–33098.
mla: Krausser, Johannes, et al. “Physical Mechanisms of Amyloid Nucleation on Fluid
Membranes.” Proceedings of the National Academy of Sciences, vol. 117,
no. 52, National Academy of Sciences, 2020, pp. 33090–98, doi:10.1073/pnas.2007694117.
short: J. Krausser, T.P.J. Knowles, A. Šarić, Proceedings of the National Academy
of Sciences 117 (2020) 33090–33098.
date_created: 2021-11-25T15:07:09Z
date_published: 2020-12-16T00:00:00Z
date_updated: 2021-11-25T15:35:58Z
day: '16'
doi: 10.1073/pnas.2007694117
extern: '1'
external_id:
pmid:
- '33328273'
intvolume: ' 117'
issue: '52'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2019.12.22.886267v2
month: '12'
oa: 1
oa_version: Published Version
page: 33090-33098
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Physical mechanisms of amyloid nucleation on fluid membranes
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 117
year: '2020'
...
---
_id: '10342'
abstract:
- lang: eng
text: The blood-brain barrier is made of polarized brain endothelial cells (BECs)
phenotypically conditioned by the central nervous system (CNS). Although transport
across BECs is of paramount importance for nutrient uptake as well as ridding
the brain of waste products, the intracellular sorting mechanisms that regulate
successful receptor-mediated transcytosis in BECs remain to be elucidated. Here,
we used a synthetic multivalent system with tunable avidity to the low-density
lipoprotein receptor–related protein 1 (LRP1) to investigate the mechanisms of
transport across BECs. We used a combination of conventional and super-resolution
microscopy, both in vivo and in vitro, accompanied with biophysical modeling of
transport kinetics and membrane-bound interactions to elucidate the role of membrane-sculpting
protein syndapin-2 on fast transport via tubule formation. We show that high-avidity
cargo biases the LRP1 toward internalization associated with fast degradation,
while mid-avidity augments the formation of syndapin-2 tubular carriers promoting
a fast shuttling across.
acknowledgement: 'Funding: G.B. thanks the ERC for the starting grant (MEViC 278793)
and consolidator award (CheSSTaG 769798), EPSRC/BTG Healthcare Partnership (EP/I001697/1),
EPSRC Established Career Fellowship (EP/N026322/1), EPSRC/SomaNautix Healthcare
Partnership EP/R024723/1, and Children with Cancer UK for the research project (16-227).
X.T. and G.B. thank that Anhui 100 Talent program for facilitating data sharing
and research visits. A.D.-C. and L.R. acknowledge the Royal Society for a Newton
fellowship and the Marie Skłodowska-Curie Actions for a European Fellowship. Author
contributions: X.T. prepared and characterized POs, performed all the fast imaging
in both conventional and STED microscopy, set up the initial BBB model, encapsulated
the PtA2 in POs, and supervised the PtA2-PO animal work. D.M.L. prepared and characterized
POs; performed all the permeability studies, PLA assays, WB and associated data
analysis, and part of the colocalization assays; and performed experiments with
the shRNA for knockdown of syndapin-2. E.S. prepared and characterized POs and performed
part of colocalization assays and Cy7-labeled PO animal experiments. S.N. prepared
and characterized POs and performed part of the colocalization and inhibition assays.
G.F. designed, performed, and analyzed the agent-based simulations of transcytosis.
J.F. designed the image-based algorithm to analyze the PLA data. D.M. prepared and
characterized POs and helped with Cy7-labeled PO animal experiments. A.A. performed
TEM imaging of the POs. A.P. and A.D.-C. synthesized the dye- and peptide-functionalized
and pristine copolymers. M.V., L.H.-K., and A.Š. designed, performed, and analyzed
the MD simulations. Z.Z. supervised and supported STED imaging. P.X., B.F., and
Y.T. synthesized and characterized the PtA2 compound. L.L. performed some of the
animal work. L.R. supported and helped with the BBB characterization. G.B. analyzed
all fast imaging and supervised and coordinated the overall work. X.T., D.M.L.,
E.S., and G.B. wrote the manuscript. Competing interests: The authors declare that
part of the work is associated with the UCL spin-out company SomaNautix Ltd. Data
and materials availability: All data needed to evaluate the conclusions in the paper
are present in the paper and/or the Supplementary Materials. Additional data related
to this paper may be requested from the authors.'
article_number: 'eabc4397 '
article_processing_charge: No
article_type: original
author:
- first_name: Xiaohe
full_name: Tian, Xiaohe
last_name: Tian
- first_name: Diana M.
full_name: Leite, Diana M.
last_name: Leite
- first_name: Edoardo
full_name: Scarpa, Edoardo
last_name: Scarpa
- first_name: Sophie
full_name: Nyberg, Sophie
last_name: Nyberg
- first_name: Gavin
full_name: Fullstone, Gavin
last_name: Fullstone
- first_name: Joe
full_name: Forth, Joe
last_name: Forth
- first_name: Diana
full_name: Matias, Diana
last_name: Matias
- first_name: Azzurra
full_name: Apriceno, Azzurra
last_name: Apriceno
- first_name: Alessandro
full_name: Poma, Alessandro
last_name: Poma
- first_name: Aroa
full_name: Duro-Castano, Aroa
last_name: Duro-Castano
- first_name: Manish
full_name: Vuyyuru, Manish
last_name: Vuyyuru
- first_name: Lena
full_name: Harker-Kirschneck, Lena
last_name: Harker-Kirschneck
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Zhongping
full_name: Zhang, Zhongping
last_name: Zhang
- first_name: Pan
full_name: Xiang, Pan
last_name: Xiang
- first_name: Bin
full_name: Fang, Bin
last_name: Fang
- first_name: Yupeng
full_name: Tian, Yupeng
last_name: Tian
- first_name: Lei
full_name: Luo, Lei
last_name: Luo
- first_name: Loris
full_name: Rizzello, Loris
last_name: Rizzello
- first_name: Giuseppe
full_name: Battaglia, Giuseppe
last_name: Battaglia
citation:
ama: 'Tian X, Leite DM, Scarpa E, et al. On the shuttling across the blood-brain
barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances.
2020;6(48). doi:10.1126/sciadv.abc4397'
apa: 'Tian, X., Leite, D. M., Scarpa, E., Nyberg, S., Fullstone, G., Forth, J.,
… Battaglia, G. (2020). On the shuttling across the blood-brain barrier via tubule
formation: Mechanism and cargo avidity bias. Science Advances. American
Association for the Advancement of Science. https://doi.org/10.1126/sciadv.abc4397'
chicago: 'Tian, Xiaohe, Diana M. Leite, Edoardo Scarpa, Sophie Nyberg, Gavin Fullstone,
Joe Forth, Diana Matias, et al. “On the Shuttling across the Blood-Brain Barrier
via Tubule Formation: Mechanism and Cargo Avidity Bias.” Science Advances.
American Association for the Advancement of Science, 2020. https://doi.org/10.1126/sciadv.abc4397.'
ieee: 'X. Tian et al., “On the shuttling across the blood-brain barrier via
tubule formation: Mechanism and cargo avidity bias,” Science Advances,
vol. 6, no. 48. American Association for the Advancement of Science, 2020.'
ista: 'Tian X, Leite DM, Scarpa E, Nyberg S, Fullstone G, Forth J, Matias D, Apriceno
A, Poma A, Duro-Castano A, Vuyyuru M, Harker-Kirschneck L, Šarić A, Zhang Z, Xiang
P, Fang B, Tian Y, Luo L, Rizzello L, Battaglia G. 2020. On the shuttling across
the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias.
Science Advances. 6(48), eabc4397.'
mla: 'Tian, Xiaohe, et al. “On the Shuttling across the Blood-Brain Barrier via
Tubule Formation: Mechanism and Cargo Avidity Bias.” Science Advances,
vol. 6, no. 48, eabc4397, American Association for the Advancement of Science,
2020, doi:10.1126/sciadv.abc4397.'
short: X. Tian, D.M. Leite, E. Scarpa, S. Nyberg, G. Fullstone, J. Forth, D. Matias,
A. Apriceno, A. Poma, A. Duro-Castano, M. Vuyyuru, L. Harker-Kirschneck, A. Šarić,
Z. Zhang, P. Xiang, B. Fang, Y. Tian, L. Luo, L. Rizzello, G. Battaglia, Science
Advances 6 (2020).
date_created: 2021-11-26T06:40:28Z
date_published: 2020-11-27T00:00:00Z
date_updated: 2021-11-26T07:00:24Z
day: '27'
ddc:
- '611'
doi: 10.1126/sciadv.abc4397
extern: '1'
external_id:
pmid:
- '33246953'
file:
- access_level: open_access
checksum: 3ba2eca975930cdb0b1ce1ae876885a7
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-26T06:50:09Z
date_updated: 2021-11-26T06:50:09Z
file_id: '10343'
file_name: 2020_SciAdv_Tian.pdf
file_size: 10381298
relation: main_file
success: 1
file_date_updated: 2021-11-26T06:50:09Z
has_accepted_license: '1'
intvolume: ' 6'
issue: '48'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2020.04.04.025866v1
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
issn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'On the shuttling across the blood-brain barrier via tubule formation: Mechanism
and cargo avidity bias'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 6
year: '2020'
...
---
_id: '10344'
abstract:
- lang: eng
text: In this study, we investigate the role of the surface patterning of nanostructures
for cell membrane reshaping. To accomplish this, we combine an evolutionary algorithm
with coarse-grained molecular dynamics simulations and explore the solution space
of ligand patterns on a nanoparticle that promote efficient and reliable cell
uptake. Surprisingly, we find that in the regime of low ligand number the best-performing
structures are characterized by ligands arranged into long one-dimensional chains
that pattern the surface of the particle. We show that these chains of ligands
provide particles with high rotational freedom and they lower the free energy
barrier for membrane crossing. Our approach reveals a set of nonintuitive design
rules that can be used to inform artificial nanoparticle construction and the
search for inhibitors of viral entry.
acknowledgement: We acknowledge support from EPSRC (J. C. F.), MRC (B. B. and A. Š.),
the ERC StG 802960 “NEPA” (J. K. and A. Š.), the Royal Society (A. Š.), and the
United Kingdom Materials and Molecular Modelling Hub for computational resources,
which is partially funded by EPSRC (EP/P020194/1).
article_number: '228101'
article_processing_charge: No
article_type: original
author:
- first_name: Joel C.
full_name: Forster, Joel C.
last_name: Forster
- first_name: Johannes
full_name: Krausser, Johannes
last_name: Krausser
- first_name: Manish R.
full_name: Vuyyuru, Manish R.
last_name: Vuyyuru
- first_name: Buzz
full_name: Baum, Buzz
last_name: Baum
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. Exploring the design rules
for efficient membrane-reshaping nanostructures. Physical Review Letters.
2020;125(22). doi:10.1103/physrevlett.125.228101
apa: Forster, J. C., Krausser, J., Vuyyuru, M. R., Baum, B., & Šarić, A. (2020).
Exploring the design rules for efficient membrane-reshaping nanostructures. Physical
Review Letters. American Physical Society. https://doi.org/10.1103/physrevlett.125.228101
chicago: Forster, Joel C., Johannes Krausser, Manish R. Vuyyuru, Buzz Baum, and
Anđela Šarić. “Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures.”
Physical Review Letters. American Physical Society, 2020. https://doi.org/10.1103/physrevlett.125.228101.
ieee: J. C. Forster, J. Krausser, M. R. Vuyyuru, B. Baum, and A. Šarić, “Exploring
the design rules for efficient membrane-reshaping nanostructures,” Physical
Review Letters, vol. 125, no. 22. American Physical Society, 2020.
ista: Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. 2020. Exploring the design
rules for efficient membrane-reshaping nanostructures. Physical Review Letters.
125(22), 228101.
mla: Forster, Joel C., et al. “Exploring the Design Rules for Efficient Membrane-Reshaping
Nanostructures.” Physical Review Letters, vol. 125, no. 22, 228101, American
Physical Society, 2020, doi:10.1103/physrevlett.125.228101.
short: J.C. Forster, J. Krausser, M.R. Vuyyuru, B. Baum, A. Šarić, Physical Review
Letters 125 (2020).
date_created: 2021-11-26T07:10:43Z
date_published: 2020-11-23T00:00:00Z
date_updated: 2021-11-30T08:33:14Z
day: '23'
ddc:
- '530'
doi: 10.1103/physrevlett.125.228101
extern: '1'
external_id:
pmid:
- '33315453'
file:
- access_level: open_access
checksum: fbf2e1415e332d6add90222d60401a1d
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-26T07:16:49Z
date_updated: 2021-11-26T07:16:49Z
file_id: '10345'
file_name: 2020_PhysRevLett_Forster.pdf
file_size: 844353
relation: main_file
success: 1
file_date_updated: 2021-11-26T07:16:49Z
has_accepted_license: '1'
intvolume: ' 125'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2020.02.27.968149v1
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Exploring the design rules for efficient membrane-reshaping nanostructures
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 125
year: '2020'
...
---
_id: '10341'
abstract:
- lang: eng
text: Tracing the motion of macromolecules, viruses, and nanoparticles adsorbed
onto cell membranes is currently the most direct way of probing the complex dynamic
interactions behind vital biological processes, including cell signalling, trafficking,
and viral infection. The resulting trajectories are usually consistent with some
type of anomalous diffusion, but the molecular origins behind the observed anomalous
behaviour are usually not obvious. Here we use coarse-grained molecular dynamics
simulations to help identify the physical mechanisms that can give rise to experimentally
observed trajectories of nanoscopic objects moving on biological membranes. We
find that diffusion on membranes of high fluidities typically results in normal
diffusion of the adsorbed nanoparticle, irrespective of the concentration of receptors,
receptor clustering, or multivalent interactions between the particle and membrane
receptors. Gel-like membranes on the other hand result in anomalous diffusion
of the particle, which becomes more pronounced at higher receptor concentrations.
This anomalous diffusion is characterised by local particle trapping in the regions
of high receptor concentrations and fast hopping between such regions. The normal
diffusion is recovered in the limit where the gel membrane is saturated with receptors.
We conclude that hindered receptor diffusivity can be a common reason behind the
observed anomalous diffusion of viruses, vesicles, and nanoparticles adsorbed
on cell and model membranes. Our results enable direct comparison with experiments
and offer a new route for interpreting motility experiments on cell membranes.
acknowledgement: We thank Jessica McQuade for her input at the start of the project.
We acknowledge support from the ERASMUS Placement Programme (V. E. D.), the UCL
Institute for the Physics of Living Systems (V. E. D. and A. Š.), the UCL Global
Engagement Fund (L. M. C. J.), and the Royal Society (A. Š.).
article_processing_charge: No
article_type: original
author:
- first_name: V. E.
full_name: Debets, V. E.
last_name: Debets
- first_name: L. M. C.
full_name: Janssen, L. M. C.
last_name: Janssen
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Debets VE, Janssen LMC, Šarić A. Characterising the diffusion of biological
nanoparticles on fluid and cross-linked membranes. Soft Matter. 2020;16(47):10628-10639.
doi:10.1039/d0sm00712a
apa: Debets, V. E., Janssen, L. M. C., & Šarić, A. (2020). Characterising the
diffusion of biological nanoparticles on fluid and cross-linked membranes. Soft
Matter. Royal Society of Chemistry. https://doi.org/10.1039/d0sm00712a
chicago: Debets, V. E., L. M. C. Janssen, and Anđela Šarić. “Characterising the
Diffusion of Biological Nanoparticles on Fluid and Cross-Linked Membranes.” Soft
Matter. Royal Society of Chemistry, 2020. https://doi.org/10.1039/d0sm00712a.
ieee: V. E. Debets, L. M. C. Janssen, and A. Šarić, “Characterising the diffusion
of biological nanoparticles on fluid and cross-linked membranes,” Soft Matter,
vol. 16, no. 47. Royal Society of Chemistry, pp. 10628–10639, 2020.
ista: Debets VE, Janssen LMC, Šarić A. 2020. Characterising the diffusion of biological
nanoparticles on fluid and cross-linked membranes. Soft Matter. 16(47), 10628–10639.
mla: Debets, V. E., et al. “Characterising the Diffusion of Biological Nanoparticles
on Fluid and Cross-Linked Membranes.” Soft Matter, vol. 16, no. 47, Royal
Society of Chemistry, 2020, pp. 10628–39, doi:10.1039/d0sm00712a.
short: V.E. Debets, L.M.C. Janssen, A. Šarić, Soft Matter 16 (2020) 10628–10639.
date_created: 2021-11-26T06:29:41Z
date_published: 2020-10-06T00:00:00Z
date_updated: 2021-11-26T07:00:33Z
day: '06'
doi: 10.1039/d0sm00712a
extern: '1'
external_id:
pmid:
- '33084724'
intvolume: ' 16'
issue: '47'
keyword:
- condensed matter physics
- general chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2020.05.01.071761v1
month: '10'
oa: 1
oa_version: Published Version
page: 10628-10639
pmid: 1
publication: Soft Matter
publication_identifier:
issn:
- 1744-683X
- 1744-6848
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Characterising the diffusion of biological nanoparticles on fluid and cross-linked
membranes
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 16
year: '2020'
...
---
_id: '10346'
abstract:
- lang: eng
text: One of the most robust examples of self-assembly in living organisms is the
formation of collagen architectures. Collagen type I molecules are a crucial component
of the extracellular matrix, where they self-assemble into fibrils of well-defined
axial striped patterns. This striped fibrillar pattern is preserved across the
animal kingdom and is important for the determination of cell phenotype, cell
adhesion, and tissue regulation and signaling. The understanding of the physical
processes that determine such a robust morphology of self-assembled collagen fibrils
is currently almost completely missing. Here, we develop a minimal coarse-grained
computational model to identify the physical principles of the assembly of collagen-mimetic
molecules. We find that screened electrostatic interactions can drive the formation
of collagen-like filaments of well-defined striped morphologies. The fibril axial
pattern is determined solely by the distribution of charges on the molecule and
is robust to the changes in protein concentration, monomer rigidity, and environmental
conditions. We show that the striped fibrillar pattern cannot be easily predicted
from the interactions between two monomers but is an emergent result of multibody
interactions. Our results can help address collagen remodeling in diseases and
aging and guide the design of collagen scaffolds for biotechnological applications.
acknowledgement: We thank Melinda Duer, Patrick Mesquida, Lucy Colwell, Lucie Liu,
Daan Frenkel, and Ivan Palaia for helpful discussions. We acknowledge support from
the Engineering and Physical Sciences Research Council (A.E.H., L.K.D., and A.Š.),
Biotechnology and Biological Sciences Research Council LIDo programme (N.G.G. and
C.A.B.), the Royal Society (A.Š.), and the UK Materials and Molecular Modelling
Hub for computational resources, which is partially funded by EPSRC ( EP/P020194/1).
article_processing_charge: No
article_type: original
author:
- first_name: Anne E.
full_name: Hafner, Anne E.
last_name: Hafner
- first_name: Noemi G.
full_name: Gyori, Noemi G.
last_name: Gyori
- first_name: Ciaran A.
full_name: Bench, Ciaran A.
last_name: Bench
- first_name: Luke K.
full_name: Davis, Luke K.
last_name: Davis
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Hafner AE, Gyori NG, Bench CA, Davis LK, Šarić A. Modeling fibrillogenesis
of collagen-mimetic molecules. Biophysical Journal. 2020;119(9):1791-1799.
doi:10.1016/j.bpj.2020.09.013
apa: Hafner, A. E., Gyori, N. G., Bench, C. A., Davis, L. K., & Šarić, A. (2020).
Modeling fibrillogenesis of collagen-mimetic molecules. Biophysical Journal.
Cell Press. https://doi.org/10.1016/j.bpj.2020.09.013
chicago: Hafner, Anne E., Noemi G. Gyori, Ciaran A. Bench, Luke K. Davis, and Anđela
Šarić. “Modeling Fibrillogenesis of Collagen-Mimetic Molecules.” Biophysical
Journal. Cell Press, 2020. https://doi.org/10.1016/j.bpj.2020.09.013.
ieee: A. E. Hafner, N. G. Gyori, C. A. Bench, L. K. Davis, and A. Šarić, “Modeling
fibrillogenesis of collagen-mimetic molecules,” Biophysical Journal, vol.
119, no. 9. Cell Press, pp. 1791–1799, 2020.
ista: Hafner AE, Gyori NG, Bench CA, Davis LK, Šarić A. 2020. Modeling fibrillogenesis
of collagen-mimetic molecules. Biophysical Journal. 119(9), 1791–1799.
mla: Hafner, Anne E., et al. “Modeling Fibrillogenesis of Collagen-Mimetic Molecules.”
Biophysical Journal, vol. 119, no. 9, Cell Press, 2020, pp. 1791–99, doi:10.1016/j.bpj.2020.09.013.
short: A.E. Hafner, N.G. Gyori, C.A. Bench, L.K. Davis, A. Šarić, Biophysical Journal
119 (2020) 1791–1799.
date_created: 2021-11-26T07:27:24Z
date_published: 2020-09-23T00:00:00Z
date_updated: 2021-11-26T07:45:24Z
day: '23'
doi: 10.1016/j.bpj.2020.09.013
extern: '1'
external_id:
pmid:
- '33049216'
intvolume: ' 119'
issue: '9'
keyword:
- biophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2020.06.08.140061v1
month: '09'
oa: 1
oa_version: Published Version
page: 1791-1799
pmid: 1
publication: Biophysical Journal
publication_identifier:
issn:
- 0006-3495
publication_status: published
publisher: Cell Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modeling fibrillogenesis of collagen-mimetic molecules
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 119
year: '2020'
...
---
_id: '10350'
abstract:
- lang: eng
text: The misfolding and aberrant aggregation of proteins into fibrillar structures
is a key factor in some of the most prevalent human diseases, including diabetes
and dementia. Low molecular weight oligomers are thought to be a central factor
in the pathology of these diseases, as well as critical intermediates in the fibril
formation process, and as such have received much recent attention. Moreover,
on-pathway oligomeric intermediates are potential targets for therapeutic strategies
aimed at interrupting the fibril formation process. However, a consistent framework
for distinguishing on-pathway from off-pathway oligomers has hitherto been lacking
and, in particular, no consensus definition of on- and off-pathway oligomers is
available. In this paper, we argue that a non-binary definition of oligomers'
contribution to fibril-forming pathways may be more informative and we suggest
a quantitative framework, in which each oligomeric species is assigned a value
between 0 and 1 describing its relative contribution to the formation of fibrils.
First, we clarify the distinction between oligomers and fibrils, and then we use
the formalism of reaction networks to develop a general definition for on-pathway
oligomers, that yields meaningful classifications in the context of amyloid formation.
By applying these concepts to Monte Carlo simulations of a minimal aggregating
system, and by revisiting several previous studies of amyloid oligomers in light
of our new framework, we demonstrate how to perform these classifications in practice.
For each oligomeric species we obtain the degree to which it is on-pathway, highlighting
the most effective pharmaceutical targets for the inhibition of amyloid fibril
formation.
acknowledgement: We are grateful to the Schiff Foundation (AJD), Peterhouse, Cambridge
(TCTM), the Swiss National Science foundation (TCTM), Ramon Jenkins Fellowship,
Sidney Sussex, Cambridge (GM), the Royal Society (AŠ), the Academy of Medical Sciences
and Wellcome Trust (AŠ), the Danish Research Council (MK), the Lundbeck Foundation
(MK), the Swedish Research Council (SL), the Wellcome Trust (TPJK), the Cambridge
Centre for Misfolding Diseases (TPJK), the BBSRC (TPJK), the Frances and Augustus
Newman Foundation (TPJK) for financial support. The research leading to these results
has received funding from the European Research Council under the European Union's
Seventh Framework Programme (FP7/2007-2013) through the ERC grants PhysProt (agreement
no. 337969), MAMBA (agreement no. 340890) and NovoNordiskFonden (SL).
article_processing_charge: No
article_type: original
author:
- first_name: Alexander J.
full_name: Dear, Alexander J.
last_name: Dear
- first_name: Georg
full_name: Meisl, Georg
last_name: Meisl
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Thomas C. T.
full_name: Michaels, Thomas C. T.
last_name: Michaels
- first_name: Magnus
full_name: Kjaergaard, Magnus
last_name: Kjaergaard
- first_name: Sara
full_name: Linse, Sara
last_name: Linse
- first_name: Tuomas P. J.
full_name: Knowles, Tuomas P. J.
last_name: Knowles
citation:
ama: Dear AJ, Meisl G, Šarić A, et al. Identification of on- and off-pathway oligomers
in amyloid fibril formation. Chemical Science. 2020;11(24):6236-6247. doi:10.1039/c9sc06501f
apa: Dear, A. J., Meisl, G., Šarić, A., Michaels, T. C. T., Kjaergaard, M., Linse,
S., & Knowles, T. P. J. (2020). Identification of on- and off-pathway oligomers
in amyloid fibril formation. Chemical Science. Royal Society of Chemistry.
https://doi.org/10.1039/c9sc06501f
chicago: Dear, Alexander J., Georg Meisl, Anđela Šarić, Thomas C. T. Michaels, Magnus
Kjaergaard, Sara Linse, and Tuomas P. J. Knowles. “Identification of On- and off-Pathway
Oligomers in Amyloid Fibril Formation.” Chemical Science. Royal Society
of Chemistry, 2020. https://doi.org/10.1039/c9sc06501f.
ieee: A. J. Dear et al., “Identification of on- and off-pathway oligomers
in amyloid fibril formation,” Chemical Science, vol. 11, no. 24. Royal
Society of Chemistry, pp. 6236–6247, 2020.
ista: Dear AJ, Meisl G, Šarić A, Michaels TCT, Kjaergaard M, Linse S, Knowles TPJ.
2020. Identification of on- and off-pathway oligomers in amyloid fibril formation.
Chemical Science. 11(24), 6236–6247.
mla: Dear, Alexander J., et al. “Identification of On- and off-Pathway Oligomers
in Amyloid Fibril Formation.” Chemical Science, vol. 11, no. 24, Royal
Society of Chemistry, 2020, pp. 6236–47, doi:10.1039/c9sc06501f.
short: A.J. Dear, G. Meisl, A. Šarić, T.C.T. Michaels, M. Kjaergaard, S. Linse,
T.P.J. Knowles, Chemical Science 11 (2020) 6236–6247.
date_created: 2021-11-26T09:08:19Z
date_published: 2020-06-08T00:00:00Z
date_updated: 2021-11-26T11:21:20Z
day: '08'
doi: 10.1039/c9sc06501f
extern: '1'
external_id:
pmid:
- '32953019'
intvolume: ' 11'
issue: '24'
keyword:
- general chemistry
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/3.0/
main_file_link:
- open_access: '1'
url: https://pubs.rsc.org/en/content/articlehtml/2020/sc/c9sc06501f
month: '06'
oa: 1
oa_version: Published Version
page: 6236-6247
pmid: 1
publication: Chemical Science
publication_identifier:
eissn:
- 2041-6539
issn:
- 2041-6520
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Identification of on- and off-pathway oligomers in amyloid fibril formation
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/3.0/legalcode
name: Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
short: CC BY-NC (3.0)
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 11
year: '2020'
...
---
_id: '10349'
abstract:
- lang: eng
text: Sulfolobus acidocaldarius is the closest experimentally tractable archaeal
relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and
cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases
of DNA replication and division. Here, in exploring the mechanism of cell division
in S. acidocaldarius, we identify a role for the archaeal proteasome in regulating
the transition from the end of one cell cycle to the beginning of the next. Further,
we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome
and show that its degradation triggers division by allowing constriction of the
CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism
for ESCRT-III–mediated membrane remodeling and point to a conserved role for the
proteasome in eukaryotic and archaeal cell cycle control.
acknowledgement: "We thank the MRC LMCB at UCL for their support; the flow cytometry
STP at the Francis Crick Institute for assistance, with special thanks to S. Purewal
and D. Davis; C. Bertoli for mentorship\r\nand advice; J. M. Garcia-Arcos for help
early on in this project; the entire Baum lab for their input throughout the project;
the Albers lab for advice and reagents, with special thanks to M. Van Wolferen and
S. Albers; the members of the Wellcome consortium for archaeal cytoskeleton studies
for advice and comments; and J. Löwe, S. Oliferenko, M. Balasubramanian, and D.
Gerlich for discussions and advice on the manuscript. N.P.R. and S.B. would like
to thank N. Rzechorzek, A. Simon, and S. Anjum for discussion and advice."
article_processing_charge: No
article_type: original
author:
- first_name: Gabriel
full_name: Tarrason Risa, Gabriel
last_name: Tarrason Risa
- first_name: Fredrik
full_name: Hurtig, Fredrik
last_name: Hurtig
- first_name: Sian
full_name: Bray, Sian
last_name: Bray
- first_name: Anne E.
full_name: Hafner, Anne E.
last_name: Hafner
- first_name: Lena
full_name: Harker-Kirschneck, Lena
last_name: Harker-Kirschneck
- first_name: Peter
full_name: Faull, Peter
last_name: Faull
- first_name: Colin
full_name: Davis, Colin
last_name: Davis
- first_name: Dimitra
full_name: Papatziamou, Dimitra
last_name: Papatziamou
- first_name: Delyan R.
full_name: Mutavchiev, Delyan R.
last_name: Mutavchiev
- first_name: Catherine
full_name: Fan, Catherine
last_name: Fan
- first_name: Leticia
full_name: Meneguello, Leticia
last_name: Meneguello
- first_name: Andre
full_name: Arashiro Pulschen, Andre
last_name: Arashiro Pulschen
- first_name: Gautam
full_name: Dey, Gautam
last_name: Dey
- first_name: Siân
full_name: Culley, Siân
last_name: Culley
- first_name: Mairi
full_name: Kilkenny, Mairi
last_name: Kilkenny
- first_name: Diorge P.
full_name: Souza, Diorge P.
last_name: Souza
- first_name: Luca
full_name: Pellegrini, Luca
last_name: Pellegrini
- first_name: Robertus A. M.
full_name: de Bruin, Robertus A. M.
last_name: de Bruin
- first_name: Ricardo
full_name: Henriques, Ricardo
last_name: Henriques
- first_name: Ambrosius P.
full_name: Snijders, Ambrosius P.
last_name: Snijders
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Ann-Christin
full_name: Lindås, Ann-Christin
last_name: Lindås
- first_name: Nicholas P.
full_name: Robinson, Nicholas P.
last_name: Robinson
- first_name: Buzz
full_name: Baum, Buzz
last_name: Baum
citation:
ama: Tarrason Risa G, Hurtig F, Bray S, et al. The proteasome controls ESCRT-III–mediated
cell division in an archaeon. Science. 2020;369(6504). doi:10.1126/science.aaz2532
apa: Tarrason Risa, G., Hurtig, F., Bray, S., Hafner, A. E., Harker-Kirschneck,
L., Faull, P., … Baum, B. (2020). The proteasome controls ESCRT-III–mediated cell
division in an archaeon. Science. American Association for the Advancement
of Science. https://doi.org/10.1126/science.aaz2532
chicago: Tarrason Risa, Gabriel, Fredrik Hurtig, Sian Bray, Anne E. Hafner, Lena
Harker-Kirschneck, Peter Faull, Colin Davis, et al. “The Proteasome Controls ESCRT-III–Mediated
Cell Division in an Archaeon.” Science. American Association for the Advancement
of Science, 2020. https://doi.org/10.1126/science.aaz2532.
ieee: G. Tarrason Risa et al., “The proteasome controls ESCRT-III–mediated
cell division in an archaeon,” Science, vol. 369, no. 6504. American Association
for the Advancement of Science, 2020.
ista: Tarrason Risa G, Hurtig F, Bray S, Hafner AE, Harker-Kirschneck L, Faull P,
Davis C, Papatziamou D, Mutavchiev DR, Fan C, Meneguello L, Arashiro Pulschen
A, Dey G, Culley S, Kilkenny M, Souza DP, Pellegrini L, de Bruin RAM, Henriques
R, Snijders AP, Šarić A, Lindås A-C, Robinson NP, Baum B. 2020. The proteasome
controls ESCRT-III–mediated cell division in an archaeon. Science. 369(6504).
mla: Tarrason Risa, Gabriel, et al. “The Proteasome Controls ESCRT-III–Mediated
Cell Division in an Archaeon.” Science, vol. 369, no. 6504, American Association
for the Advancement of Science, 2020, doi:10.1126/science.aaz2532.
short: G. Tarrason Risa, F. Hurtig, S. Bray, A.E. Hafner, L. Harker-Kirschneck,
P. Faull, C. Davis, D. Papatziamou, D.R. Mutavchiev, C. Fan, L. Meneguello, A.
Arashiro Pulschen, G. Dey, S. Culley, M. Kilkenny, D.P. Souza, L. Pellegrini,
R.A.M. de Bruin, R. Henriques, A.P. Snijders, A. Šarić, A.-C. Lindås, N.P. Robinson,
B. Baum, Science 369 (2020).
date_created: 2021-11-26T08:21:34Z
date_published: 2020-08-07T00:00:00Z
date_updated: 2021-11-26T08:58:33Z
day: '07'
doi: 10.1126/science.aaz2532
extern: '1'
external_id:
pmid:
- '32764038'
intvolume: ' 369'
issue: '6504'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/774273v1
month: '08'
oa: 1
oa_version: Preprint
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: The proteasome controls ESCRT-III–mediated cell division in an archaeon
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 369
year: '2020'
...
---
_id: '10347'
abstract:
- lang: eng
text: Understanding the mechanism of action of compounds capable of inhibiting amyloid-fibril
formation is critical to the development of potential therapeutics against protein-misfolding
diseases. A fundamental challenge for progress is the range of possible target
species and the disparate timescales involved, since the aggregating proteins
are simultaneously the reactants, products, intermediates, and catalysts of the
reaction. It is a complex problem, therefore, to choose the states of the aggregating
proteins that should be bound by the compounds to achieve the most potent inhibition.
We present here a comprehensive kinetic theory of amyloid-aggregation inhibition
that reveals the fundamental thermodynamic and kinetic signatures characterizing
effective inhibitors by identifying quantitative relationships between the aggregation
and binding rate constants. These results provide general physical laws to guide
the design and optimization of inhibitors of amyloid-fibril formation, revealing
in particular the important role of on-rates in the binding of the inhibitors.
acknowledgement: We acknowledge support from Peterhouse, Cambridge (T.C.T.M.); the
Swiss National Science Foundation (T.C.T.M.); the Royal Society (A.S. and S.C.);
the Academy of Medical Sciences (A.S.); Sidney Sussex College, Cambridge (G.M.);
Newnham College, Cambridge (G.T.H.); the Wellcome Trust (T.P.J.K.); the Cambridge
Center for Misfolding Diseases (T.P.J.K. and M.V.); the Biotechnology and Biological
Sciences Research Council (T.P.J.K.); the Frances and Augustus Newman Foundation
(T.P.J.K.); and the Synapsis Foundation for Alzheimer’s disease (P.A.). The research
leading to these results has received funding from the European Research Council
(ERC) under the European Union’s Seventh Framework Program (FP7/2007-2013) through
the ERC Grant PhysProt (Agreement 337969).
article_processing_charge: No
article_type: original
author:
- first_name: Thomas C. T.
full_name: Michaels, Thomas C. T.
last_name: Michaels
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Georg
full_name: Meisl, Georg
last_name: Meisl
- first_name: Gabriella T.
full_name: Heller, Gabriella T.
last_name: Heller
- first_name: Samo
full_name: Curk, Samo
last_name: Curk
- first_name: Paolo
full_name: Arosio, Paolo
last_name: Arosio
- first_name: Sara
full_name: Linse, Sara
last_name: Linse
- first_name: Christopher M.
full_name: Dobson, Christopher M.
last_name: Dobson
- first_name: Michele
full_name: Vendruscolo, Michele
last_name: Vendruscolo
- first_name: Tuomas P. J.
full_name: Knowles, Tuomas P. J.
last_name: Knowles
citation:
ama: Michaels TCT, Šarić A, Meisl G, et al. Thermodynamic and kinetic design principles
for amyloid-aggregation inhibitors. Proceedings of the National Academy of
Sciences. 2020;117(39):24251-24257. doi:10.1073/pnas.2006684117
apa: Michaels, T. C. T., Šarić, A., Meisl, G., Heller, G. T., Curk, S., Arosio,
P., … Knowles, T. P. J. (2020). Thermodynamic and kinetic design principles for
amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences.
National Academy of Sciences. https://doi.org/10.1073/pnas.2006684117
chicago: Michaels, Thomas C. T., Anđela Šarić, Georg Meisl, Gabriella T. Heller,
Samo Curk, Paolo Arosio, Sara Linse, Christopher M. Dobson, Michele Vendruscolo,
and Tuomas P. J. Knowles. “Thermodynamic and Kinetic Design Principles for Amyloid-Aggregation
Inhibitors.” Proceedings of the National Academy of Sciences. National
Academy of Sciences, 2020. https://doi.org/10.1073/pnas.2006684117.
ieee: T. C. T. Michaels et al., “Thermodynamic and kinetic design principles
for amyloid-aggregation inhibitors,” Proceedings of the National Academy of
Sciences, vol. 117, no. 39. National Academy of Sciences, pp. 24251–24257,
2020.
ista: Michaels TCT, Šarić A, Meisl G, Heller GT, Curk S, Arosio P, Linse S, Dobson
CM, Vendruscolo M, Knowles TPJ. 2020. Thermodynamic and kinetic design principles
for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences.
117(39), 24251–24257.
mla: Michaels, Thomas C. T., et al. “Thermodynamic and Kinetic Design Principles
for Amyloid-Aggregation Inhibitors.” Proceedings of the National Academy of
Sciences, vol. 117, no. 39, National Academy of Sciences, 2020, pp. 24251–57,
doi:10.1073/pnas.2006684117.
short: T.C.T. Michaels, A. Šarić, G. Meisl, G.T. Heller, S. Curk, P. Arosio, S.
Linse, C.M. Dobson, M. Vendruscolo, T.P.J. Knowles, Proceedings of the National
Academy of Sciences 117 (2020) 24251–24257.
date_created: 2021-11-26T07:48:27Z
date_published: 2020-09-14T00:00:00Z
date_updated: 2021-11-26T08:59:06Z
day: '14'
doi: 10.1073/pnas.2006684117
extern: '1'
external_id:
pmid:
- '32929030'
intvolume: ' 117'
issue: '39'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2020.02.22.960716
month: '09'
oa: 1
oa_version: Published Version
page: 24251-24257
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 117
year: '2020'
...
---
_id: '10351'
abstract:
- lang: eng
text: Oligomeric species populated during the aggregation of the Aβ42 peptide have
been identified as potent cytotoxins linked to Alzheimer’s disease, but the fundamental
molecular pathways that control their dynamics have yet to be elucidated. By developing
a general approach that combines theory, experiment and simulation, we reveal,
in molecular detail, the mechanisms of Aβ42 oligomer dynamics during amyloid fibril
formation. Even though all mature amyloid fibrils must originate as oligomers,
we found that most Aβ42 oligomers dissociate into their monomeric precursors without
forming new fibrils. Only a minority of oligomers converts into fibrillar structures.
Moreover, the heterogeneous ensemble of oligomeric species interconverts on timescales
comparable to those of aggregation. Our results identify fundamentally new steps
that could be targeted by therapeutic interventions designed to combat protein
misfolding diseases.
acknowledgement: We acknowledge support from Peterhouse (T.C.T.M.), the Swiss National
Science foundation (T.C.T.M.), the Royal Society (A.Š.), the Academy of Medical
Sciences (A.Š.), the UCL Institute for the Physics of Living Systems (S.C.), Sidney
Sussex College (G.M.), the Wellcome Trust (A.Š., M.V., C.M.D. and T.P.J.K.), the
Schiff Foundation (A.J.D.), the Cambridge Centre for Misfolding Diseases (M.V.,
C.M.D. and T.P.J.K.), the BBSRC (C.M.D. and T.P.J.K.), the Frances and Augustus
Newman Foundation (T.P.J.K.), the Swedish Research Council (S.L.) and the ERC grant
MAMBA (S.L., agreement no. 340890). The research that led to these results received
funding from the European Research Council under the European Union’s Seventh Framework
Programme (FP7/2007-2013) through the ERC grant PhysProt (agreement no. 337969).
article_processing_charge: No
article_type: original
author:
- first_name: Thomas C. T.
full_name: Michaels, Thomas C. T.
last_name: Michaels
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Samo
full_name: Curk, Samo
last_name: Curk
- first_name: Katja
full_name: Bernfur, Katja
last_name: Bernfur
- first_name: Paolo
full_name: Arosio, Paolo
last_name: Arosio
- first_name: Georg
full_name: Meisl, Georg
last_name: Meisl
- first_name: Alexander J.
full_name: Dear, Alexander J.
last_name: Dear
- first_name: Samuel I. A.
full_name: Cohen, Samuel I. A.
last_name: Cohen
- first_name: Christopher M.
full_name: Dobson, Christopher M.
last_name: Dobson
- first_name: Michele
full_name: Vendruscolo, Michele
last_name: Vendruscolo
- first_name: Sara
full_name: Linse, Sara
last_name: Linse
- first_name: Tuomas P. J.
full_name: Knowles, Tuomas P. J.
last_name: Knowles
citation:
ama: Michaels TCT, Šarić A, Curk S, et al. Dynamics of oligomer populations formed
during the aggregation of Alzheimer’s Aβ42 peptide. Nature Chemistry. 2020;12(5):445-451.
doi:10.1038/s41557-020-0452-1
apa: Michaels, T. C. T., Šarić, A., Curk, S., Bernfur, K., Arosio, P., Meisl, G.,
… Knowles, T. P. J. (2020). Dynamics of oligomer populations formed during the
aggregation of Alzheimer’s Aβ42 peptide. Nature Chemistry. Springer Nature.
https://doi.org/10.1038/s41557-020-0452-1
chicago: Michaels, Thomas C. T., Anđela Šarić, Samo Curk, Katja Bernfur, Paolo Arosio,
Georg Meisl, Alexander J. Dear, et al. “Dynamics of Oligomer Populations Formed
during the Aggregation of Alzheimer’s Aβ42 Peptide.” Nature Chemistry.
Springer Nature, 2020. https://doi.org/10.1038/s41557-020-0452-1.
ieee: T. C. T. Michaels et al., “Dynamics of oligomer populations formed
during the aggregation of Alzheimer’s Aβ42 peptide,” Nature Chemistry,
vol. 12, no. 5. Springer Nature, pp. 445–451, 2020.
ista: Michaels TCT, Šarić A, Curk S, Bernfur K, Arosio P, Meisl G, Dear AJ, Cohen
SIA, Dobson CM, Vendruscolo M, Linse S, Knowles TPJ. 2020. Dynamics of oligomer
populations formed during the aggregation of Alzheimer’s Aβ42 peptide. Nature
Chemistry. 12(5), 445–451.
mla: Michaels, Thomas C. T., et al. “Dynamics of Oligomer Populations Formed during
the Aggregation of Alzheimer’s Aβ42 Peptide.” Nature Chemistry, vol. 12,
no. 5, Springer Nature, 2020, pp. 445–51, doi:10.1038/s41557-020-0452-1.
short: T.C.T. Michaels, A. Šarić, S. Curk, K. Bernfur, P. Arosio, G. Meisl, A.J.
Dear, S.I.A. Cohen, C.M. Dobson, M. Vendruscolo, S. Linse, T.P.J. Knowles, Nature
Chemistry 12 (2020) 445–451.
date_created: 2021-11-26T09:15:13Z
date_published: 2020-04-13T00:00:00Z
date_updated: 2021-11-26T11:21:08Z
day: '13'
doi: 10.1038/s41557-020-0452-1
extern: '1'
external_id:
pmid:
- '32303714'
intvolume: ' 12'
issue: '5'
keyword:
- general chemical engineering
- general chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2020.01.08.897488
month: '04'
oa: 1
oa_version: None
page: 445-451
pmid: 1
publication: Nature Chemistry
publication_identifier:
eissn:
- 1755-4349
issn:
- 1755-4330
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41557-020-0468-6
scopus_import: '1'
status: public
title: Dynamics of oligomer populations formed during the aggregation of Alzheimer’s
Aβ42 peptide
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 12
year: '2020'
...
---
_id: '10348'
abstract:
- lang: eng
text: The endosomal sorting complex required for transport-III (ESCRT-III) catalyzes
membrane fission from within membrane necks, a process that is essential for many
cellular functions, from cell division to lysosome degradation and autophagy.
How it breaks membranes, though, remains unknown. Here, we characterize a sequential
polymerization of ESCRT-III subunits that, driven by a recruitment cascade and
by continuous subunit-turnover powered by the ATPase Vps4, induces membrane deformation
and fission. During this process, the exchange of Vps24 for Did2 induces a tilt
in the polymer-membrane interface, which triggers transition from flat spiral
polymers to helical filament to drive the formation of membrane protrusions, and
ends with the formation of a highly constricted Did2-Ist1 co-polymer that we show
is competent to promote fission when bound on the inside of membrane necks. Overall,
our results suggest a mechanism of stepwise changes in ESCRT-III filament structure
and mechanical properties via exchange of the filament subunits to catalyze ESCRT-III
activity.
acknowledgement: The authors thank Nicolas Chiaruttini, Jean Gruenberg, and Lena Harker-Kirschneck
for careful correction of this manuscript and helpful discussions. The authors want
to thank the NCCR Chemical Biology for constant support during this project. A.R.
acknowledges funding from the Swiss National Fund for Research (31003A_130520, 31003A_149975,
and 31003A_173087) and the European Research Council Consolidator (311536). A.Š.
acknowledges the European Research Council (802960). B.B. thanks the BBSRC (BB/K009001/1)
and Wellcome Trust (203276/Z/16/Z) for support. J.M.v.F. acknowledges funding through
an EMBO Long-Term Fellowship (ALTF 1065-2015), the European Commission FP7 (Marie
Curie Actions, LTFCOFUND2013, and GA-2013-609409), and a Transitional Postdoc fellowship
(2015/345) from the Swiss SystemsX.ch initiative, evaluated by the Swiss National
Science Foundation and Swiss National Science Foundation Research (SNSF SINERGIA
160728/1 [leader, Sophie Martin]).
article_processing_charge: No
article_type: original
author:
- first_name: Anna-Katharina
full_name: Pfitzner, Anna-Katharina
last_name: Pfitzner
- first_name: Vincent
full_name: Mercier, Vincent
last_name: Mercier
- first_name: Xiuyun
full_name: Jiang, Xiuyun
last_name: Jiang
- first_name: Joachim
full_name: Moser von Filseck, Joachim
last_name: Moser von Filseck
- first_name: Buzz
full_name: Baum, Buzz
last_name: Baum
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Aurélien
full_name: Roux, Aurélien
last_name: Roux
citation:
ama: Pfitzner A-K, Mercier V, Jiang X, et al. An ESCRT-III polymerization sequence
drives membrane deformation and fission. Cell. 2020;182(5):1140-1155.e18.
doi:10.1016/j.cell.2020.07.021
apa: Pfitzner, A.-K., Mercier, V., Jiang, X., Moser von Filseck, J., Baum, B., Šarić,
A., & Roux, A. (2020). An ESCRT-III polymerization sequence drives membrane
deformation and fission. Cell. Elsevier. https://doi.org/10.1016/j.cell.2020.07.021
chicago: Pfitzner, Anna-Katharina, Vincent Mercier, Xiuyun Jiang, Joachim Moser
von Filseck, Buzz Baum, Anđela Šarić, and Aurélien Roux. “An ESCRT-III Polymerization
Sequence Drives Membrane Deformation and Fission.” Cell. Elsevier, 2020.
https://doi.org/10.1016/j.cell.2020.07.021.
ieee: A.-K. Pfitzner et al., “An ESCRT-III polymerization sequence drives
membrane deformation and fission,” Cell, vol. 182, no. 5. Elsevier, p.
1140–1155.e18, 2020.
ista: Pfitzner A-K, Mercier V, Jiang X, Moser von Filseck J, Baum B, Šarić A, Roux
A. 2020. An ESCRT-III polymerization sequence drives membrane deformation and
fission. Cell. 182(5), 1140–1155.e18.
mla: Pfitzner, Anna-Katharina, et al. “An ESCRT-III Polymerization Sequence Drives
Membrane Deformation and Fission.” Cell, vol. 182, no. 5, Elsevier, 2020,
p. 1140–1155.e18, doi:10.1016/j.cell.2020.07.021.
short: A.-K. Pfitzner, V. Mercier, X. Jiang, J. Moser von Filseck, B. Baum, A. Šarić,
A. Roux, Cell 182 (2020) 1140–1155.e18.
date_created: 2021-11-26T08:02:27Z
date_published: 2020-08-18T00:00:00Z
date_updated: 2021-11-26T08:58:37Z
day: '18'
doi: 10.1016/j.cell.2020.07.021
extern: '1'
external_id:
pmid:
- '32814015'
intvolume: ' 182'
issue: '5'
keyword:
- general biochemistry
- genetics and molecular biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0092867420309296
month: '08'
oa: 1
oa_version: Published Version
page: 1140-1155.e18
pmid: 1
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: An ESCRT-III polymerization sequence drives membrane deformation and fission
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 182
year: '2020'
...
---
_id: '10352'
abstract:
- lang: eng
text: In the nuclear pore complex, intrinsically disordered nuclear pore proteins
(FG Nups) form a selective barrier for transport into and out of the cell nucleus,
in a way that remains poorly understood. The collective FG Nup behavior has long
been conceptualized either as a polymer brush, dominated by entropic and excluded-volume
(repulsive) interactions, or as a hydrogel, dominated by cohesive (attractive)
interactions between FG Nups. Here we compare mesoscale computational simulations
with a wide range of experimental data to demonstrate that FG Nups are at the
crossover point between these two regimes. Specifically, we find that repulsive
and attractive interactions are balanced, resulting in morphologies and dynamics
that are close to those of ideal polymer chains. We demonstrate that this property
of FG Nups yields sufficient cohesion to seal the transport barrier, and yet maintains
fast dynamics at the molecular scale, permitting the rapid polymer rearrangements
needed for transport events.
acknowledgement: We thank Dino Osmanović (MIT), Roy Beck (Tel-Aviv), Larissa Kapinos
(Basel), Roderick Lim (Basel), Ralf Richter (Leeds), and Anton Zilman (Toronto)
for discussions. This work was funded by the Royal Society (A.Š.) and the UK Engineering
and Physical Sciences Research Council (EP/L504889/1, B.W.H.).
article_number: '022420'
article_processing_charge: No
article_type: original
author:
- first_name: Luke K.
full_name: Davis, Luke K.
last_name: Davis
- first_name: Ian J.
full_name: Ford, Ian J.
last_name: Ford
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Bart W.
full_name: Hoogenboom, Bart W.
last_name: Hoogenboom
citation:
ama: Davis LK, Ford IJ, Šarić A, Hoogenboom BW. Intrinsically disordered nuclear
pore proteins show ideal-polymer morphologies and dynamics. Physical Review
E. 2020;101(2). doi:10.1103/physreve.101.022420
apa: Davis, L. K., Ford, I. J., Šarić, A., & Hoogenboom, B. W. (2020). Intrinsically
disordered nuclear pore proteins show ideal-polymer morphologies and dynamics.
Physical Review E. American Physical Society. https://doi.org/10.1103/physreve.101.022420
chicago: Davis, Luke K., Ian J. Ford, Anđela Šarić, and Bart W. Hoogenboom. “Intrinsically
Disordered Nuclear Pore Proteins Show Ideal-Polymer Morphologies and Dynamics.”
Physical Review E. American Physical Society, 2020. https://doi.org/10.1103/physreve.101.022420.
ieee: L. K. Davis, I. J. Ford, A. Šarić, and B. W. Hoogenboom, “Intrinsically disordered
nuclear pore proteins show ideal-polymer morphologies and dynamics,” Physical
Review E, vol. 101, no. 2. American Physical Society, 2020.
ista: Davis LK, Ford IJ, Šarić A, Hoogenboom BW. 2020. Intrinsically disordered
nuclear pore proteins show ideal-polymer morphologies and dynamics. Physical Review
E. 101(2), 022420.
mla: Davis, Luke K., et al. “Intrinsically Disordered Nuclear Pore Proteins Show
Ideal-Polymer Morphologies and Dynamics.” Physical Review E, vol. 101,
no. 2, 022420, American Physical Society, 2020, doi:10.1103/physreve.101.022420.
short: L.K. Davis, I.J. Ford, A. Šarić, B.W. Hoogenboom, Physical Review E 101 (2020).
date_created: 2021-11-26T09:41:04Z
date_published: 2020-02-28T00:00:00Z
date_updated: 2021-11-26T11:21:16Z
day: '28'
doi: 10.1103/physreve.101.022420
extern: '1'
external_id:
pmid:
- '32168597'
intvolume: ' 101'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/571687
month: '02'
oa: 1
oa_version: Preprint
pmid: 1
publication: Physical Review E
publication_identifier:
eissn:
- 2470-0053
issn:
- 2470-0045
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Intrinsically disordered nuclear pore proteins show ideal-polymer morphologies
and dynamics
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 101
year: '2020'
...
---
_id: '10353'
abstract:
- lang: eng
text: Experiments have suggested that bacterial mechanosensitive channels separate
into 2D clusters, the role of which is unclear. By developing a coarse-grained
computer model we find that clustering promotes the channel closure, which is
highly dependent on the channel concentration and membrane stress. This behaviour
yields a tightly regulated gating system, whereby at high tensions channels gate
individually, and at lower tensions the channels spontaneously aggregate and inactivate.
We implement this positive feedback into the model for cell volume regulation,
and find that the channel clustering protects the cell against excessive loss
of cytoplasmic content.
acknowledgement: We thank Samantha Miller, Bert Poolman, and the members of Šarić
and Pilizota laboratories for useful discussion. We acknowledge support from the
Engineering and Physical Sciences Research Council (A.P. and A.Š.), the UCL Institute
for the Physics of Living Systems (A.P. and A.Š.), Darwin Trust of University of
Edinburgh (H.S.), Industrial Biotechnology Innovation Centre (H.S. and T.P.), BBSRC
Council Crossing Biological Membrane Network (H.S. and T.P.), BBSRC/EPSRC/MRC Synthetic
Biology Research Centre (T.P.), and the Royal Society (A.Š.).
article_number: '048102'
article_processing_charge: No
article_type: original
author:
- first_name: Alexandru
full_name: Paraschiv, Alexandru
last_name: Paraschiv
- first_name: Smitha
full_name: Hegde, Smitha
last_name: Hegde
- first_name: Raman
full_name: Ganti, Raman
last_name: Ganti
- first_name: Teuta
full_name: Pilizota, Teuta
last_name: Pilizota
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Paraschiv A, Hegde S, Ganti R, Pilizota T, Šarić A. Dynamic clustering regulates
activity of mechanosensitive membrane channels. Physical Review Letters.
2020;124(4). doi:10.1103/physrevlett.124.048102
apa: Paraschiv, A., Hegde, S., Ganti, R., Pilizota, T., & Šarić, A. (2020).
Dynamic clustering regulates activity of mechanosensitive membrane channels. Physical
Review Letters. American Physical Society. https://doi.org/10.1103/physrevlett.124.048102
chicago: Paraschiv, Alexandru, Smitha Hegde, Raman Ganti, Teuta Pilizota, and Anđela
Šarić. “Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels.”
Physical Review Letters. American Physical Society, 2020. https://doi.org/10.1103/physrevlett.124.048102.
ieee: A. Paraschiv, S. Hegde, R. Ganti, T. Pilizota, and A. Šarić, “Dynamic clustering
regulates activity of mechanosensitive membrane channels,” Physical Review
Letters, vol. 124, no. 4. American Physical Society, 2020.
ista: Paraschiv A, Hegde S, Ganti R, Pilizota T, Šarić A. 2020. Dynamic clustering
regulates activity of mechanosensitive membrane channels. Physical Review Letters.
124(4), 048102.
mla: Paraschiv, Alexandru, et al. “Dynamic Clustering Regulates Activity of Mechanosensitive
Membrane Channels.” Physical Review Letters, vol. 124, no. 4, 048102, American
Physical Society, 2020, doi:10.1103/physrevlett.124.048102.
short: A. Paraschiv, S. Hegde, R. Ganti, T. Pilizota, A. Šarić, Physical Review
Letters 124 (2020).
date_created: 2021-11-26T09:57:01Z
date_published: 2020-01-31T00:00:00Z
date_updated: 2021-11-26T11:21:12Z
day: '31'
doi: 10.1103/physrevlett.124.048102
extern: '1'
external_id:
pmid:
- '32058787'
intvolume: ' 124'
issue: '4'
keyword:
- general physics and astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/553248
month: '01'
oa: 1
oa_version: Preprint
pmid: 1
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic clustering regulates activity of mechanosensitive membrane channels
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 124
year: '2020'
...
---
_id: '10557'
abstract:
- lang: eng
text: Data storage and retrieval systems, methods, and computer-readable media utilize
a cryptographically verifiable data structure that facilitates verification of
a transaction in a decentralized peer-to-peer environment using multi-hop backwards
and forwards links. Backward links are cryptographic hashes of past records. Forward
links are cryptographic signatures of future records that are added retroactively
to records once the target block has been appended to the data structure.
applicant:
- Ecole Polytechnique Federale de Lausanne
application_date: 2017-06-09
article_processing_charge: No
author:
- first_name: Bryan
full_name: Ford, Bryan
last_name: Ford
- first_name: Linus
full_name: Gasse, Linus
last_name: Gasse
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Philipp
full_name: Jovanovic, Philipp
last_name: Jovanovic
citation:
ama: Ford B, Gasse L, Kokoris Kogias E, Jovanovic P. Cryptographically verifiable
data structure having multi-hop forward and backwards links and associated systems
and methods. 2020.
apa: Ford, B., Gasse, L., Kokoris Kogias, E., & Jovanovic, P. (2020). Cryptographically
verifiable data structure having multi-hop forward and backwards links and associated
systems and methods.
chicago: Ford, Bryan, Linus Gasse, Eleftherios Kokoris Kogias, and Philipp Jovanovic.
“Cryptographically Verifiable Data Structure Having Multi-Hop Forward and Backwards
Links and Associated Systems and Methods,” 2020.
ieee: B. Ford, L. Gasse, E. Kokoris Kogias, and P. Jovanovic, “Cryptographically
verifiable data structure having multi-hop forward and backwards links and associated
systems and methods.” 2020.
ista: Ford B, Gasse L, Kokoris Kogias E, Jovanovic P. 2020. Cryptographically verifiable
data structure having multi-hop forward and backwards links and associated systems
and methods.
mla: Ford, Bryan, et al. Cryptographically Verifiable Data Structure Having Multi-Hop
Forward and Backwards Links and Associated Systems and Methods. 2020.
short: B. Ford, L. Gasse, E. Kokoris Kogias, P. Jovanovic, (2020).
date_created: 2021-12-16T13:28:59Z
date_published: 2020-03-03T00:00:00Z
date_updated: 2021-12-21T10:04:50Z
day: '03'
department:
- _id: ElKo
extern: '1'
ipc: ' H04L9/3247 ; G06Q20/29 ; G06Q20/382 ; H04L9/3236'
ipn: '10581613'
main_file_link:
- open_access: '1'
url: https://patents.google.com/patent/US10581613B2/en
month: '03'
oa: 1
oa_version: Published Version
publication_date: 2020-03-03
related_material:
link:
- relation: earlier_version
url: https://patents.google.com/patent/US20180359096A1/en
status: public
title: Cryptographically verifiable data structure having multi-hop forward and backwards
links and associated systems and methods
type: patent
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2020'
...
---
_id: '10618'
abstract:
- lang: eng
text: Magnetism typically arises from the joint effect of Fermi statistics and repulsive
Coulomb interactions, which favours ground states with non-zero electron spin.
As a result, controlling spin magnetism with electric fields—a longstanding technological
goal in spintronics and multiferroics1,2—can be achieved only indirectly. Here
we experimentally demonstrate direct electric-field control of magnetic states
in an orbital Chern insulator3,4,5,6, a magnetic system in which non-trivial band
topology favours long-range order of orbital angular momentum but the spins are
thought to remain disordered7,8,9,10,11,12,13,14. We use van der Waals heterostructures
consisting of a graphene monolayer rotationally faulted with respect to a Bernal-stacked
bilayer to realize narrow and topologically non-trivial valley-projected moiré
minibands15,16,17. At fillings of one and three electrons per moiré unit cell
within these bands, we observe quantized anomalous Hall effects18 with transverse
resistance approximately equal to h/2e2 (where h is Planck’s constant and e is
the charge on the electron), which is indicative of spontaneous polarization of
the system into a single-valley-projected band with a Chern number equal to two.
At a filling of three electrons per moiré unit cell, we find that the sign of
the quantum anomalous Hall effect can be reversed via field-effect control of
the chemical potential; moreover, this transition is hysteretic, which we use
to demonstrate non-volatile electric-field-induced reversal of the magnetic state.
A theoretical analysis19 indicates that the effect arises from the topological
edge states, which drive a change in sign of the magnetization and thus a reversal
in the favoured magnetic state. Voltage control of magnetic states can be used
to electrically pattern non-volatile magnetic-domain structures hosting chiral
edge states, with applications ranging from reconfigurable microwave circuit elements
to ultralow-power magnetic memories.
acknowledgement: We acknowledge discussions with J. Checkelsky, S. Chen, C. Dean,
M. Yankowitz, D. Reilly, I. Sodemann and M. Zaletel. Work at UCSB was primarily
supported by the ARO under MURI W911NF-16-1-0361. Measurements of twisted bilayer
graphene (Extended Data Fig. 8) and measurements at elevated temperatures (Extended
Data Fig. 3) were supported by a SEED grant and made use of shared facilities of
the UCSB MRSEC (NSF DMR 1720256), a member of the Materials Research Facilities
Network (www.mrfn.org). A.F.Y. acknowledges the support of the David and Lucille
Packard Foundation under award 2016-65145. A.H.M. and J.Z. were supported by the
National Science Foundation through the Center for Dynamics and Control of Materials,
an NSF MRSEC under Cooperative Agreement number DMR-1720595, and by the Welch Foundation
under grant TBF1473. C.L.T. acknowledges support from the Hertz Foundation and from
the National Science Foundation Graduate Research Fellowship Program under grant
1650114. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative
conducted by the MEXT, Japan, Grant Number JPMXP0112101001, JSPS KAKENHI grant numbers
JP20H00354 and the CREST(JPMJCR15F3), JST.
article_processing_charge: No
article_type: original
author:
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: J.
full_name: Zhu, J.
last_name: Zhu
- first_name: M. A.
full_name: Kumar, M. A.
last_name: Kumar
- first_name: Y.
full_name: Zhang, Y.
last_name: Zhang
- first_name: F.
full_name: Yang, F.
last_name: Yang
- first_name: C. L.
full_name: Tschirhart, C. L.
last_name: Tschirhart
- first_name: M.
full_name: Serlin, M.
last_name: Serlin
- first_name: K.
full_name: Watanabe, K.
last_name: Watanabe
- first_name: T.
full_name: Taniguchi, T.
last_name: Taniguchi
- first_name: A. H.
full_name: MacDonald, A. H.
last_name: MacDonald
- first_name: A. F.
full_name: Young, A. F.
last_name: Young
citation:
ama: Polshyn H, Zhu J, Kumar MA, et al. Electrical switching of magnetic order in
an orbital Chern insulator. Nature. 2020;588(7836):66-70. doi:10.1038/s41586-020-2963-8
apa: Polshyn, H., Zhu, J., Kumar, M. A., Zhang, Y., Yang, F., Tschirhart, C. L.,
… Young, A. F. (2020). Electrical switching of magnetic order in an orbital Chern
insulator. Nature. Springer Nature. https://doi.org/10.1038/s41586-020-2963-8
chicago: Polshyn, Hryhoriy, J. Zhu, M. A. Kumar, Y. Zhang, F. Yang, C. L. Tschirhart,
M. Serlin, et al. “Electrical Switching of Magnetic Order in an Orbital Chern
Insulator.” Nature. Springer Nature, 2020. https://doi.org/10.1038/s41586-020-2963-8.
ieee: H. Polshyn et al., “Electrical switching of magnetic order in an orbital
Chern insulator,” Nature, vol. 588, no. 7836. Springer Nature, pp. 66–70,
2020.
ista: Polshyn H, Zhu J, Kumar MA, Zhang Y, Yang F, Tschirhart CL, Serlin M, Watanabe
K, Taniguchi T, MacDonald AH, Young AF. 2020. Electrical switching of magnetic
order in an orbital Chern insulator. Nature. 588(7836), 66–70.
mla: Polshyn, Hryhoriy, et al. “Electrical Switching of Magnetic Order in an Orbital
Chern Insulator.” Nature, vol. 588, no. 7836, Springer Nature, 2020, pp.
66–70, doi:10.1038/s41586-020-2963-8.
short: H. Polshyn, J. Zhu, M.A. Kumar, Y. Zhang, F. Yang, C.L. Tschirhart, M. Serlin,
K. Watanabe, T. Taniguchi, A.H. MacDonald, A.F. Young, Nature 588 (2020) 66–70.
date_created: 2022-01-13T14:12:17Z
date_published: 2020-11-23T00:00:00Z
date_updated: 2022-01-13T14:21:04Z
day: '23'
doi: 10.1038/s41586-020-2963-8
extern: '1'
external_id:
arxiv:
- '2004.11353'
pmid:
- '33230333'
intvolume: ' 588'
issue: '7836'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2004.11353
month: '11'
oa: 1
oa_version: Preprint
page: 66-70
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Electrical switching of magnetic order in an orbital Chern insulator
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 588
year: '2020'
...
---
_id: '10650'
abstract:
- lang: eng
text: The understanding of material systems with strong electron-electron interactions
is the central problem in modern condensed matter physics. Despite this, the essential
physics of many of these materials is still not understood and we have no overall
perspective on their properties. Moreover, we have very little ability to make
predictions in this class of systems. In this manuscript we share our personal
views of what the major open problems are in correlated electron systems and we
discuss some possible routes to make progress in this rich and fascinating field.
This manuscript is the result of the vigorous discussions and deliberations that
took place at Johns Hopkins University during a three-day workshop January 27,
28, and 29, 2020 that brought together six senior scientists and 46 more junior
scientists. Our hope, is that the topics we have presented will provide inspiration
for others working in this field and motivation for the idea that significant
progress can be made on very hard problems if we focus our collective energies.
acknowledgement: "We thank NSF CMP program for suggestions regarding the topic and
general structure of the workshop. This project was supported by the NSF DMR-2002329
and The Gordon and Betty Moore Foundation (GBMF) EPiQS initiative. We would like
to sincerely thank A. Kapitulnik, A. J. Leggett, M.B. Maple, T.M. McQueen, M. Norman,
P. S. Riseborough, and G. A. Sawatzky for their lectures at the workshop and advice
on the writing of this manuscript. We would also like to thank G. Blumberg, C. Broholm,
S. Crooker, N. Drichko, and A. Patel for helpful consultation on topics discussed\r\nherein.
A number of individuals also had independent support: (AA, EH; GBMF-4305), (IMH;
GBMF-9071), (HJC; NHMFL is supported by the NSF DMR-1644779 and the state of Florida),
(YH, AZ; Miller Institute for Basic Research in Science), (YC; US DOE-BES DEAC02-06CH11357),
(AS; Spallation Neutron Source, a DOE Office of Science User Facility operated by
ORNL), (SAAG; ARO-W911NF-18-1-0290, NSF DMR-1455233), (YW; DOE-BES DE-SC0019331,
GBMF-4532)."
article_processing_charge: No
author:
- first_name: A
full_name: Alexandradinata, A
last_name: Alexandradinata
- first_name: N.P.
full_name: Armitage, N.P.
last_name: Armitage
- first_name: Andrey
full_name: Baydin, Andrey
last_name: Baydin
- first_name: Wenli
full_name: Bi, Wenli
last_name: Bi
- first_name: Yue
full_name: Cao, Yue
last_name: Cao
- first_name: Hitesh J.
full_name: Changlani, Hitesh J.
last_name: Changlani
- first_name: Eli
full_name: Chertkov, Eli
last_name: Chertkov
- first_name: Eduardo H.
full_name: da Silva Neto, Eduardo H.
last_name: da Silva Neto
- first_name: Luca
full_name: Delacretaz, Luca
last_name: Delacretaz
- first_name: Ismail
full_name: El Baggari, Ismail
last_name: El Baggari
- first_name: G.M.
full_name: Ferguson, G.M.
last_name: Ferguson
- first_name: William J.
full_name: Gannon, William J.
last_name: Gannon
- first_name: Sayed Ali Akbar
full_name: Ghorashi, Sayed Ali Akbar
last_name: Ghorashi
- first_name: Berit H.
full_name: Goodge, Berit H.
last_name: Goodge
- first_name: Olga
full_name: Goulko, Olga
last_name: Goulko
- first_name: G.
full_name: Grissonnache, G.
last_name: Grissonnache
- first_name: Alannah
full_name: Hallas, Alannah
last_name: Hallas
- first_name: Ian M.
full_name: Hayes, Ian M.
last_name: Hayes
- first_name: Yu
full_name: He, Yu
last_name: He
- first_name: Edwin W.
full_name: Huang, Edwin W.
last_name: Huang
- first_name: Anshu
full_name: Kogar, Anshu
last_name: Kogar
- first_name: Divine
full_name: Kumah, Divine
last_name: Kumah
- first_name: Jong Yeon
full_name: Lee, Jong Yeon
last_name: Lee
- first_name: A.
full_name: Legros, A.
last_name: Legros
- first_name: Fahad
full_name: Mahmood, Fahad
last_name: Mahmood
- first_name: Yulia
full_name: Maximenko, Yulia
last_name: Maximenko
- first_name: Nick
full_name: Pellatz, Nick
last_name: Pellatz
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Tarapada
full_name: Sarkar, Tarapada
last_name: Sarkar
- first_name: Allen
full_name: Scheie, Allen
last_name: Scheie
- first_name: Kyle L.
full_name: Seyler, Kyle L.
last_name: Seyler
- first_name: Zhenzhong
full_name: Shi, Zhenzhong
last_name: Shi
- first_name: Brian
full_name: Skinner, Brian
last_name: Skinner
- first_name: Lucia
full_name: Steinke, Lucia
last_name: Steinke
- first_name: K.
full_name: Thirunavukkuarasu, K.
last_name: Thirunavukkuarasu
- first_name: Thaís Victa
full_name: Trevisan, Thaís Victa
last_name: Trevisan
- first_name: Michael
full_name: Vogl, Michael
last_name: Vogl
- first_name: Pavel A.
full_name: Volkov, Pavel A.
last_name: Volkov
- first_name: Yao
full_name: Wang, Yao
last_name: Wang
- first_name: Yishu
full_name: Wang, Yishu
last_name: Wang
- first_name: Di
full_name: Wei, Di
last_name: Wei
- first_name: Kaya
full_name: Wei, Kaya
last_name: Wei
- first_name: Shuolong
full_name: Yang, Shuolong
last_name: Yang
- first_name: Xian
full_name: Zhang, Xian
last_name: Zhang
- first_name: Ya-Hui
full_name: Zhang, Ya-Hui
last_name: Zhang
- first_name: Liuyan
full_name: Zhao, Liuyan
last_name: Zhao
- first_name: Alfred
full_name: Zong, Alfred
last_name: Zong
citation:
ama: Alexandradinata A, Armitage NP, Baydin A, et al. The future of the correlated
electron problem. arXiv.
apa: Alexandradinata, A., Armitage, N. P., Baydin, A., Bi, W., Cao, Y., Changlani,
H. J., … Zong, A. (n.d.). The future of the correlated electron problem. arXiv.
chicago: Alexandradinata, A, N.P. Armitage, Andrey Baydin, Wenli Bi, Yue Cao, Hitesh
J. Changlani, Eli Chertkov, et al. “The Future of the Correlated Electron Problem.”
ArXiv, n.d.
ieee: A. Alexandradinata et al., “The future of the correlated electron problem,”
arXiv. .
ista: Alexandradinata A, Armitage NP, Baydin A, Bi W, Cao Y, Changlani HJ, Chertkov
E, da Silva Neto EH, Delacretaz L, El Baggari I, Ferguson GM, Gannon WJ, Ghorashi
SAA, Goodge BH, Goulko O, Grissonnache G, Hallas A, Hayes IM, He Y, Huang EW,
Kogar A, Kumah D, Lee JY, Legros A, Mahmood F, Maximenko Y, Pellatz N, Polshyn
H, Sarkar T, Scheie A, Seyler KL, Shi Z, Skinner B, Steinke L, Thirunavukkuarasu
K, Trevisan TV, Vogl M, Volkov PA, Wang Y, Wang Y, Wei D, Wei K, Yang S, Zhang
X, Zhang Y-H, Zhao L, Zong A. The future of the correlated electron problem. arXiv,
.
mla: Alexandradinata, A., et al. “The Future of the Correlated Electron Problem.”
ArXiv.
short: A. Alexandradinata, N.P. Armitage, A. Baydin, W. Bi, Y. Cao, H.J. Changlani,
E. Chertkov, E.H. da Silva Neto, L. Delacretaz, I. El Baggari, G.M. Ferguson,
W.J. Gannon, S.A.A. Ghorashi, B.H. Goodge, O. Goulko, G. Grissonnache, A. Hallas,
I.M. Hayes, Y. He, E.W. Huang, A. Kogar, D. Kumah, J.Y. Lee, A. Legros, F. Mahmood,
Y. Maximenko, N. Pellatz, H. Polshyn, T. Sarkar, A. Scheie, K.L. Seyler, Z. Shi,
B. Skinner, L. Steinke, K. Thirunavukkuarasu, T.V. Trevisan, M. Vogl, P.A. Volkov,
Y. Wang, Y. Wang, D. Wei, K. Wei, S. Yang, X. Zhang, Y.-H. Zhang, L. Zhao, A.
Zong, ArXiv (n.d.).
date_created: 2022-01-20T10:55:36Z
date_published: 2020-10-01T00:00:00Z
date_updated: 2022-01-24T08:05:51Z
day: '01'
extern: '1'
external_id:
arxiv:
- '2010.00584'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2010.00584
month: '10'
oa: 1
oa_version: Preprint
page: '55'
publication: arXiv
publication_status: submitted
status: public
title: The future of the correlated electron problem
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2020'
...
---
_id: '10673'
abstract:
- lang: eng
text: We propose a neural information processing system obtained by re-purposing
the function of a biological neural circuit model to govern simulated and real-world
control tasks. Inspired by the structure of the nervous system of the soil-worm,
C. elegans, we introduce ordinary neural circuits (ONCs), defined as the model
of biological neural circuits reparameterized for the control of alternative tasks.
We first demonstrate that ONCs realize networks with higher maximum flow compared
to arbitrary wired networks. We then learn instances of ONCs to control a series
of robotic tasks, including the autonomous parking of a real-world rover robot.
For reconfiguration of the purpose of the neural circuit, we adopt a search-based
optimization algorithm. Ordinary neural circuits perform on par and, in some cases,
significantly surpass the performance of contemporary deep learning models. ONC
networks are compact, 77% sparser than their counterpart neural controllers, and
their neural dynamics are fully interpretable at the cell-level.
acknowledgement: "RH and RG are partially supported by Horizon-2020 ECSEL Project
grant No. 783163 (iDev40), Productive 4.0, and ATBMBFW CPS-IoT Ecosystem. ML was
supported in part by the Austrian Science Fund (FWF) under grant Z211-N23\r\n(Wittgenstein
Award). AA is supported by the National Science Foundation (NSF) Graduate Research
Fellowship\r\nProgram. RH and DR are partially supported by The Boeing Company and
JP Morgan Chase. This research work is\r\npartially drawn from the PhD dissertation
of RH.\r\n"
alternative_title:
- PMLR
article_processing_charge: No
author:
- first_name: Ramin
full_name: Hasani, Ramin
last_name: Hasani
- first_name: Mathias
full_name: Lechner, Mathias
id: 3DC22916-F248-11E8-B48F-1D18A9856A87
last_name: Lechner
- first_name: Alexander
full_name: Amini, Alexander
last_name: Amini
- first_name: Daniela
full_name: Rus, Daniela
last_name: Rus
- first_name: Radu
full_name: Grosu, Radu
last_name: Grosu
citation:
ama: 'Hasani R, Lechner M, Amini A, Rus D, Grosu R. A natural lottery ticket winner:
Reinforcement learning with ordinary neural circuits. In: Proceedings of the
37th International Conference on Machine Learning. PMLR. ; 2020:4082-4093.'
apa: 'Hasani, R., Lechner, M., Amini, A., Rus, D., & Grosu, R. (2020). A natural
lottery ticket winner: Reinforcement learning with ordinary neural circuits. In
Proceedings of the 37th International Conference on Machine Learning (pp.
4082–4093). Virtual.'
chicago: 'Hasani, Ramin, Mathias Lechner, Alexander Amini, Daniela Rus, and Radu
Grosu. “A Natural Lottery Ticket Winner: Reinforcement Learning with Ordinary
Neural Circuits.” In Proceedings of the 37th International Conference on Machine
Learning, 4082–93. PMLR, 2020.'
ieee: 'R. Hasani, M. Lechner, A. Amini, D. Rus, and R. Grosu, “A natural lottery
ticket winner: Reinforcement learning with ordinary neural circuits,” in Proceedings
of the 37th International Conference on Machine Learning, Virtual, 2020, pp.
4082–4093.'
ista: 'Hasani R, Lechner M, Amini A, Rus D, Grosu R. 2020. A natural lottery ticket
winner: Reinforcement learning with ordinary neural circuits. Proceedings of the
37th International Conference on Machine Learning. ML: Machine LearningPMLR, PMLR,
, 4082–4093.'
mla: 'Hasani, Ramin, et al. “A Natural Lottery Ticket Winner: Reinforcement Learning
with Ordinary Neural Circuits.” Proceedings of the 37th International Conference
on Machine Learning, 2020, pp. 4082–93.'
short: R. Hasani, M. Lechner, A. Amini, D. Rus, R. Grosu, in:, Proceedings of the
37th International Conference on Machine Learning, 2020, pp. 4082–4093.
conference:
end_date: 2020-07-18
location: Virtual
name: 'ML: Machine Learning'
start_date: 2020-07-12
date_created: 2022-01-25T15:50:34Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2022-01-26T11:14:27Z
ddc:
- '000'
department:
- _id: GradSch
- _id: ToHe
file:
- access_level: open_access
checksum: c9a4a29161777fc1a89ef451c040e3b1
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-26T11:08:51Z
date_updated: 2022-01-26T11:08:51Z
file_id: '10691'
file_name: 2020_PMLR_Hasani.pdf
file_size: 2329798
relation: main_file
success: 1
file_date_updated: 2022-01-26T11:08:51Z
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/3.0/
main_file_link:
- open_access: '1'
url: http://proceedings.mlr.press/v119/hasani20a.html
oa: 1
oa_version: Published Version
page: 4082-4093
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: Proceedings of the 37th International Conference on Machine Learning
publication_identifier:
issn:
- 2640-3498
publication_status: published
quality_controlled: '1'
scopus_import: '1'
series_title: PMLR
status: public
title: 'A natural lottery ticket winner: Reinforcement learning with ordinary neural
circuits'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/3.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND
3.0)
short: CC BY-NC-ND (3.0)
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2020'
...
---
_id: '10693'
abstract:
- lang: eng
text: High quality graphene heterostructures host an array of fractional quantum
Hall isospin ferromagnets with diverse spin and valley orders. While a variety
of phase transitions have been observed, disentangling the isospin phase diagram
of these states is hampered by the absence of direct probes of spin and valley
order. I will describe nonlocal transport measurements based on launching spin
waves from a gate defined lateral heterojunction, performed in ultra-clean Corbino
geometry graphene devices. At high magnetic fields, we find that the spin-wave
transport signal is detected in all FQH states between ν = 0 and 1; however, between
ν = 1 and 2 only odd numerator FQH states show finite nonlocal transport, despite
the identical ground state spin polarizations in odd- and even numerator states.
The results reveal that the neutral spin-waves are both spin and sublattice polarized
making them a sensitive probe of ground state sublattice structure. Armed with
this understanding, we use nonlocal transport signal to a magnetic field tuned
isospin phase transition, showing that the emergent even denominator state at
ν = 1/2 in monolayer graphene is indeed a multicomponent state featuring equal
populations on each sublattice.
alternative_title:
- Bulletin of the American Physical Society
article_number: B54. 00007
article_processing_charge: No
author:
- first_name: Haoxin
full_name: Zhou, Haoxin
last_name: Zhou
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Takashi
full_name: Tanaguchi, Takashi
last_name: Tanaguchi
- first_name: Kenji
full_name: Watanabe, Kenji
last_name: Watanabe
- first_name: Andrea
full_name: Young, Andrea
last_name: Young
citation:
ama: 'Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. Sublattice resolved spin
wave transport through graphene fractional quantum Hall states as a probe of isospin
order. In: APS March Meeting 2020. Vol 65. American Physical Society; 2020.'
apa: 'Zhou, H., Polshyn, H., Tanaguchi, T., Watanabe, K., & Young, A. (2020).
Sublattice resolved spin wave transport through graphene fractional quantum Hall
states as a probe of isospin order. In APS March Meeting 2020 (Vol. 65).
Denver, CO, United States: American Physical Society.'
chicago: Zhou, Haoxin, Hryhoriy Polshyn, Takashi Tanaguchi, Kenji Watanabe, and
Andrea Young. “Sublattice Resolved Spin Wave Transport through Graphene Fractional
Quantum Hall States as a Probe of Isospin Order.” In APS March Meeting 2020,
Vol. 65. American Physical Society, 2020.
ieee: H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, and A. Young, “Sublattice
resolved spin wave transport through graphene fractional quantum Hall states as
a probe of isospin order,” in APS March Meeting 2020, Denver, CO, United
States, 2020, vol. 65, no. 1.
ista: 'Zhou H, Polshyn H, Tanaguchi T, Watanabe K, Young A. 2020. Sublattice resolved
spin wave transport through graphene fractional quantum Hall states as a probe
of isospin order. APS March Meeting 2020. APS: American Physical Society, Bulletin
of the American Physical Society, vol. 65, B54. 00007.'
mla: Zhou, Haoxin, et al. “Sublattice Resolved Spin Wave Transport through Graphene
Fractional Quantum Hall States as a Probe of Isospin Order.” APS March Meeting
2020, vol. 65, no. 1, B54. 00007, American Physical Society, 2020.
short: H. Zhou, H. Polshyn, T. Tanaguchi, K. Watanabe, A. Young, in:, APS March
Meeting 2020, American Physical Society, 2020.
conference:
end_date: 2020-03-06
location: Denver, CO, United States
name: 'APS: American Physical Society'
start_date: 2020-03-02
date_created: 2022-01-27T10:50:10Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2022-01-27T10:58:38Z
day: '01'
extern: '1'
intvolume: ' 65'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://meetings.aps.org/Meeting/MAR20/Session/B54.7
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2020
publication_identifier:
issn:
- 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Sublattice resolved spin wave transport through graphene fractional quantum
Hall states as a probe of isospin order
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 65
year: '2020'
...
---
_id: '10698'
abstract:
- lang: eng
text: This is the second of three talks describing the observation and characterization
of a ferromagnetic moiré heterostructure based on twisted bilayer graphene aligned
to hexagonal boron nitride. I will compare the qualitative and quantitative features
of this observed quantum anomalous Hall state to traditional systems engineered
from thin film (Bi,Sb)2Te3 topological insulators. In particular, we find that
the measured electronic energy gap of ~30K is several times higher than the Curie
temperature, consistent with a lack of disorder associated with magnetic dopants.
In this system, the quantization arises from spontaneous ferromagnetic polarization
into a single spin and valley moiré subband, which is topological despite the
lack of spin orbit coupling. I will also discuss the observation of current induced
switching, which allows the magnetic state of the heterostructure to be controllably
reversed with currents as small as a few nanoamperes.
acknowledgement: I would like to thank the MURI Program, AFOSR, Sloan Foundation,
and the ARO for their generous support of this work.
alternative_title:
- Bulletin of the American Physical Society
article_number: B59.00011
article_processing_charge: No
author:
- first_name: Marec
full_name: Serlin, Marec
last_name: Serlin
- first_name: Charles
full_name: Tschirhart, Charles
last_name: Tschirhart
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Yuxuan
full_name: Zhang, Yuxuan
last_name: Zhang
- first_name: Jiacheng
full_name: Zhu, Jiacheng
last_name: Zhu
- first_name: Martin E.
full_name: Huber, Martin E.
last_name: Huber
- first_name: Leon
full_name: Balents, Leon
last_name: Balents
- first_name: Kenji
full_name: Watanabe, Kenji
last_name: Watanabe
- first_name: Takashi
full_name: Tanaguchi, Takashi
last_name: Tanaguchi
- first_name: Andrea
full_name: Young, Andrea
last_name: Young
citation:
ama: 'Serlin M, Tschirhart C, Polshyn H, et al. Intrinsic quantized anomalous Hall
effect in a moiré heterostructure, part II: Temperature dependence and current
switching. In: APS March Meeting 2020. Vol 65. American Physical Society;
2020.'
apa: 'Serlin, M., Tschirhart, C., Polshyn, H., Zhang, Y., Zhu, J., Huber, M. E.,
… Young, A. (2020). Intrinsic quantized anomalous Hall effect in a moiré heterostructure,
part II: Temperature dependence and current switching. In APS March Meeting
2020 (Vol. 65). Denver, CO, United States: American Physical Society.'
chicago: 'Serlin, Marec, Charles Tschirhart, Hryhoriy Polshyn, Yuxuan Zhang, Jiacheng
Zhu, Martin E. Huber, Leon Balents, Kenji Watanabe, Takashi Tanaguchi, and Andrea
Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure,
Part II: Temperature Dependence and Current Switching.” In APS March Meeting
2020, Vol. 65. American Physical Society, 2020.'
ieee: 'M. Serlin et al., “Intrinsic quantized anomalous Hall effect in a
moiré heterostructure, part II: Temperature dependence and current switching,”
in APS March Meeting 2020, Denver, CO, United States, 2020, vol. 65, no.
1.'
ista: 'Serlin M, Tschirhart C, Polshyn H, Zhang Y, Zhu J, Huber ME, Balents L, Watanabe
K, Tanaguchi T, Young A. 2020. Intrinsic quantized anomalous Hall effect in a
moiré heterostructure, part II: Temperature dependence and current switching.
APS March Meeting 2020. APS: American Physical Society, Bulletin of the American
Physical Society, vol. 65, B59.00011.'
mla: 'Serlin, Marec, et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré
Heterostructure, Part II: Temperature Dependence and Current Switching.” APS
March Meeting 2020, vol. 65, no. 1, B59.00011, American Physical Society,
2020.'
short: M. Serlin, C. Tschirhart, H. Polshyn, Y. Zhang, J. Zhu, M.E. Huber, L. Balents,
K. Watanabe, T. Tanaguchi, A. Young, in:, APS March Meeting 2020, American Physical
Society, 2020.
conference:
end_date: 2020-03-06
location: Denver, CO, United States
name: 'APS: American Physical Society'
start_date: 2020-03-02
date_created: 2022-01-28T10:46:57Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2023-02-21T15:57:52Z
day: '01'
extern: '1'
external_id:
arxiv:
- '1907.00261'
intvolume: ' 65'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://meetings.aps.org/Meeting/MAR20/Session/B59.11
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2020
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
record:
- id: '10619'
relation: other
status: public
status: public
title: 'Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part
II: Temperature dependence and current switching'
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 65
year: '2020'
...
---
_id: '10699'
abstract:
- lang: eng
text: This is the third of three talks describing the observation and characterization
of a ferromagnetic moiré heterostructure based on twisted bilayer graphene aligned
to hexagonal boron nitride. In this segment I will present scanning probe magnetometry
data acquired using a nanoSQUID-on-tip microscope, which provides ~150 nm spatial
resolution and a field sensitivity of ~10 nT/rtHz. We study the distribution of
magnetic domains within the device as a function of density, magnetic field training,
and DC current. Our data allow us to constrain the magnitude of the orbital magnetic
moment of the electrons in the QAH state. Comparison with simultaneously acquired
transport data allows us to precisely correlate single domain dynamics with discrete
jumps in the observed anomalous Hall signal.
acknowledgement: I would like to thank the MURI program, Sloan foundation, AFOSR,
and ARO for their generous support of this work. I would also like to thank the
NSF GRFP and the Hertz foundation for their generous support of my graduate studies.
alternative_title:
- Bulletin of the American Physical Society
article_number: B59.00013
article_processing_charge: No
author:
- first_name: Charles
full_name: Tschirhart, Charles
last_name: Tschirhart
- first_name: Marec
full_name: Serlin, Marec
last_name: Serlin
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Yuxuan
full_name: Zhang, Yuxuan
last_name: Zhang
- first_name: Jiacheng
full_name: Zhu, Jiacheng
last_name: Zhu
- first_name: Leon
full_name: Balents, Leon
last_name: Balents
- first_name: Martin E.
full_name: Huber, Martin E.
last_name: Huber
- first_name: Kenji
full_name: Watanabe, Kenji
last_name: Watanabe
- first_name: Takashi
full_name: Tanaguchi, Takashi
last_name: Tanaguchi
- first_name: Andrea
full_name: Young, Andrea
last_name: Young
citation:
ama: 'Tschirhart C, Serlin M, Polshyn H, et al. Intrinsic quantized anomalous Hall
effect in a moiré heterostructure, part III: Scanning probe magnetometry. In:
APS March Meeting 2020. Vol 65. American Physical Society; 2020.'
apa: 'Tschirhart, C., Serlin, M., Polshyn, H., Zhang, Y., Zhu, J., Balents, L.,
… Young, A. (2020). Intrinsic quantized anomalous Hall effect in a moiré heterostructure,
part III: Scanning probe magnetometry. In APS March Meeting 2020 (Vol.
65). Denver, CO, United States: American Physical Society.'
chicago: 'Tschirhart, Charles, Marec Serlin, Hryhoriy Polshyn, Yuxuan Zhang, Jiacheng
Zhu, Leon Balents, Martin E. Huber, Kenji Watanabe, Takashi Tanaguchi, and Andrea
Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure,
Part III: Scanning Probe Magnetometry.” In APS March Meeting 2020, Vol.
65. American Physical Society, 2020.'
ieee: 'C. Tschirhart et al., “Intrinsic quantized anomalous Hall effect in
a moiré heterostructure, part III: Scanning probe magnetometry,” in APS March
Meeting 2020, Denver, CO, United States, 2020, vol. 65, no. 1.'
ista: 'Tschirhart C, Serlin M, Polshyn H, Zhang Y, Zhu J, Balents L, Huber ME, Watanabe
K, Tanaguchi T, Young A. 2020. Intrinsic quantized anomalous Hall effect in a
moiré heterostructure, part III: Scanning probe magnetometry. APS March Meeting
2020. APS: American Physical Society, Bulletin of the American Physical Society,
vol. 65, B59.00013.'
mla: 'Tschirhart, Charles, et al. “Intrinsic Quantized Anomalous Hall Effect in
a Moiré Heterostructure, Part III: Scanning Probe Magnetometry.” APS March
Meeting 2020, vol. 65, no. 1, B59.00013, American Physical Society, 2020.'
short: C. Tschirhart, M. Serlin, H. Polshyn, Y. Zhang, J. Zhu, L. Balents, M.E.
Huber, K. Watanabe, T. Tanaguchi, A. Young, in:, APS March Meeting 2020, American
Physical Society, 2020.
conference:
end_date: 2020-03-06
location: Denver, CO, United States
name: 'APS: American Physical Society'
start_date: 2020-03-02
date_created: 2022-01-28T10:57:49Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2023-02-21T15:57:52Z
day: '01'
extern: '1'
external_id:
arxiv:
- '1907.00261'
intvolume: ' 65'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://meetings.aps.org/Meeting/MAR20/Session/B59.13
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2020
publication_identifier:
issn:
- 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
record:
- id: '10619'
relation: other
status: public
status: public
title: 'Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part
III: Scanning probe magnetometry'
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 65
year: '2020'
...
---
_id: '10697'
abstract:
- lang: eng
text: We report the observation of a quantized anomalous Hall effect in a moiré
heterostructure consisting of twisted bilayer graphene aligned to an encapsulating
hBN substrate. The effect occurs at a density of 3 electrons per superlattice
unit cell, where we observe magnetic hysteresis and a Hall resistance quantized
to within 0.1% of the resistance quantum at temperatures as high as 3K. In this
first of 3 talks, I will describe the fabrication procedure for our device as
well as basic transport characterization measurements. I will introduce the phenomenology
of twisted bilayer graphene and present evidence for hBN alignment as manifested
in the hierarchy of symmetry-breaking gaps and anomalous magnetoresistance.
acknowledgement: I would like to thank the MURI program, Sloan foundation, AFOSR,
and ARO for their generous support of this work.
alternative_title:
- Bulletin of the American Physical Society
article_number: B59.00012
article_processing_charge: No
author:
- first_name: Yuxuan
full_name: Zhang, Yuxuan
last_name: Zhang
- first_name: Marec
full_name: Serlin, Marec
last_name: Serlin
- first_name: Charles
full_name: Tschirhart, Charles
last_name: Tschirhart
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Jiacheng
full_name: Zhu, Jiacheng
last_name: Zhu
- first_name: Leon
full_name: Balents, Leon
last_name: Balents
- first_name: Martin E.
full_name: Huber, Martin E.
last_name: Huber
- first_name: Takashi
full_name: Taniguchi, Takashi
last_name: Taniguchi
- first_name: Kenji
full_name: Watanabe, Kenji
last_name: Watanabe
- first_name: Andrea
full_name: Young, Andrea
last_name: Young
citation:
ama: 'Zhang Y, Serlin M, Tschirhart C, et al. Intrinsic quantized anomalous Hall
effect in a moiré heterostructure, part I: Device fabrication and transport. In:
APS March Meeting 2020. Vol 65. American Physical Society; 2020.'
apa: 'Zhang, Y., Serlin, M., Tschirhart, C., Polshyn, H., Zhu, J., Balents, L.,
… Young, A. (2020). Intrinsic quantized anomalous Hall effect in a moiré heterostructure,
part I: Device fabrication and transport. In APS March Meeting 2020 (Vol.
65). Denver, CO, United States: American Physical Society.'
chicago: 'Zhang, Yuxuan, Marec Serlin, Charles Tschirhart, Hryhoriy Polshyn, Jiacheng
Zhu, Leon Balents, Martin E. Huber, Takashi Taniguchi, Kenji Watanabe, and Andrea
Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure,
Part I: Device Fabrication and Transport.” In APS March Meeting 2020, Vol.
65. American Physical Society, 2020.'
ieee: 'Y. Zhang et al., “Intrinsic quantized anomalous Hall effect in a moiré
heterostructure, part I: Device fabrication and transport,” in APS March Meeting
2020, Denver, CO, United States, 2020, vol. 65, no. 1.'
ista: 'Zhang Y, Serlin M, Tschirhart C, Polshyn H, Zhu J, Balents L, Huber ME, Taniguchi
T, Watanabe K, Young A. 2020. Intrinsic quantized anomalous Hall effect in a moiré
heterostructure, part I: Device fabrication and transport. APS March Meeting 2020.
APS: American Physical Society, Bulletin of the American Physical Society, vol.
65, B59.00012.'
mla: 'Zhang, Yuxuan, et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré
Heterostructure, Part I: Device Fabrication and Transport.” APS March Meeting
2020, vol. 65, no. 1, B59.00012, American Physical Society, 2020.'
short: Y. Zhang, M. Serlin, C. Tschirhart, H. Polshyn, J. Zhu, L. Balents, M.E.
Huber, T. Taniguchi, K. Watanabe, A. Young, in:, APS March Meeting 2020, American
Physical Society, 2020.
conference:
end_date: 2020-03-06
location: Denver, CO, United States
name: 'APS: American Physical Society'
start_date: 2020-03-02
date_created: 2022-01-28T10:28:35Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2023-02-21T15:57:52Z
day: '01'
extern: '1'
external_id:
arxiv:
- '1907.00261'
intvolume: ' 65'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://meetings.aps.org/Meeting/MAR20/Session/B59.12
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2020
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
record:
- id: '10619'
relation: other
status: public
status: public
title: 'Intrinsic quantized anomalous Hall effect in a moiré heterostructure, part
I: Device fabrication and transport'
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 65
year: '2020'
...
---
_id: '10696'
abstract:
- lang: eng
text: We experimentally investigate twisted van der Waals heterostructures of monolayer
graphene rotated with respect to a bernal stacked graphene bilayer. We report
transport measurements for devices with twist angles between 0.9 and 1.4°. The
electric field allows efficient tuning of the width, isolation and the topology
of the moiré bands in this system. By comparing magnetoresistance measurements
to numerical simulations, we develop an understanding of the band structure. Finally,
we observe correlated states at half- and quarter-fillings, which arise when narrow
moire sublattice band is isolated by energy gaps from dispersive bands. We investigate
the effects of in-plane and out-of-plane magnetic field on these states and discuss
the implication for their spin- and valley- polarization.
alternative_title:
- Bulletin of the American Physical Society
article_number: B51.00005
article_processing_charge: No
author:
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Jihang
full_name: Zhu, Jihang
last_name: Zhu
- first_name: Manish
full_name: Kumar, Manish
last_name: Kumar
- first_name: Takashi
full_name: Taniguchi, Takashi
last_name: Taniguchi
- first_name: Kenji
full_name: Watanabe, Kenji
last_name: Watanabe
- first_name: Allan
full_name: MacDonald, Allan
last_name: MacDonald
- first_name: Andrea
full_name: Young, Andrea
last_name: Young
citation:
ama: 'Polshyn H, Zhu J, Kumar M, et al. Correlated states and tunable topological
bands in twisted monolayer-bilayer graphene heterostructures. In: APS March
Meeting 2020. Vol 65. American Physical Society; 2020.'
apa: 'Polshyn, H., Zhu, J., Kumar, M., Taniguchi, T., Watanabe, K., MacDonald, A.,
& Young, A. (2020). Correlated states and tunable topological bands in twisted
monolayer-bilayer graphene heterostructures. In APS March Meeting 2020
(Vol. 65). Denver, CO, United States: American Physical Society.'
chicago: Polshyn, Hryhoriy, Jihang Zhu, Manish Kumar, Takashi Taniguchi, Kenji Watanabe,
Allan MacDonald, and Andrea Young. “Correlated States and Tunable Topological
Bands in Twisted Monolayer-Bilayer Graphene Heterostructures.” In APS March
Meeting 2020, Vol. 65. American Physical Society, 2020.
ieee: H. Polshyn et al., “Correlated states and tunable topological bands
in twisted monolayer-bilayer graphene heterostructures,” in APS March Meeting
2020, Denver, CO, United States, 2020, vol. 65, no. 1.
ista: 'Polshyn H, Zhu J, Kumar M, Taniguchi T, Watanabe K, MacDonald A, Young A.
2020. Correlated states and tunable topological bands in twisted monolayer-bilayer
graphene heterostructures. APS March Meeting 2020. APS: American Physical Society,
Bulletin of the American Physical Society, vol. 65, B51.00005.'
mla: Polshyn, Hryhoriy, et al. “Correlated States and Tunable Topological Bands
in Twisted Monolayer-Bilayer Graphene Heterostructures.” APS March Meeting
2020, vol. 65, no. 1, B51.00005, American Physical Society, 2020.
short: H. Polshyn, J. Zhu, M. Kumar, T. Taniguchi, K. Watanabe, A. MacDonald, A.
Young, in:, APS March Meeting 2020, American Physical Society, 2020.
conference:
end_date: 2020-03-06
location: Denver, CO, United States
name: 'APS: American Physical Society'
start_date: 2020-03-02
date_created: 2022-01-28T10:09:19Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2022-02-08T10:22:08Z
day: '01'
extern: '1'
intvolume: ' 65'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://meetings.aps.org/Meeting/MAR20/Session/B51.5
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2020
publication_identifier:
issn:
- 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Correlated states and tunable topological bands in twisted monolayer-bilayer
graphene heterostructures
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 65
year: '2020'
...
---
_id: '10701'
abstract:
- lang: eng
text: Partially filled Landau levels host competing electronic orders. For example,
electron solids may prevail close to integer filling of the Landau levels before
giving way to fractional quantum Hall liquids at higher carrier density1,2. Here,
we report the observation of an electron solid with non-collinear spin texture
in monolayer graphene, consistent with solidification of skyrmions3—topological
spin textures characterized by quantized electrical charge4,5. We probe the spin
texture of the solids using a modified Corbino geometry that allows ferromagnetic
magnons to be launched and detected6,7. We find that magnon transport is highly
efficient when one Landau level is filled (ν=1), consistent with quantum Hall
ferromagnetic spin polarization. However, even minimal doping immediately quenches
the magnon signal while leaving the vanishing low-temperature charge conductivity
unchanged. Our results can be understood by the formation of a solid of charged
skyrmions near ν=1, whose non-collinear spin texture leads to rapid magnon decay.
Data near fractional fillings show evidence of several fractional skyrmion solids,
suggesting that graphene hosts a highly tunable landscape of coupled spin and
charge orders.
acknowledgement: We acknowledge discussions with B. Halperin, C. Huang, A. Macdonald
and M. Zalatel. Experimental work at UCSB was supported by the Army Research Office
under awards nos. MURI W911NF-16-1-0361 and W911NF-16-1-0482. K.W. and T.T. acknowledge
support from the Elemental Strategy Initiative conducted by MEXT (Japan) and CREST
(JPMJCR15F3), JST. A.F.Y. acknowledges the support of the David and Lucile Packard
Foundation and and Alfred. P. Sloan Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Haoxin
full_name: Zhou, Haoxin
last_name: Zhou
- first_name: Hryhoriy
full_name: Polshyn, Hryhoriy
id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
last_name: Polshyn
orcid: 0000-0001-8223-8896
- first_name: Takashi
full_name: Taniguchi, Takashi
last_name: Taniguchi
- first_name: Kenji
full_name: Watanabe, Kenji
last_name: Watanabe
- first_name: Andrea F.
full_name: Young, Andrea F.
last_name: Young
citation:
ama: Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. Skyrmion solids in monolayer
graphene. Nature Physics. 2020;16(2):154-158. doi:10.1038/s41567-019-0729-8
apa: Zhou, H., Polshyn, H., Taniguchi, T., Watanabe, K., & Young, A. F. (2020).
Skyrmion solids in monolayer graphene. Nature Physics. Springer Nature.
https://doi.org/10.1038/s41567-019-0729-8
chicago: Zhou, Haoxin, Hryhoriy Polshyn, Takashi Taniguchi, Kenji Watanabe, and
Andrea F. Young. “Skyrmion Solids in Monolayer Graphene.” Nature Physics.
Springer Nature, 2020. https://doi.org/10.1038/s41567-019-0729-8.
ieee: H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, and A. F. Young, “Skyrmion
solids in monolayer graphene,” Nature Physics, vol. 16, no. 2. Springer
Nature, pp. 154–158, 2020.
ista: Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. 2020. Skyrmion solids
in monolayer graphene. Nature Physics. 16(2), 154–158.
mla: Zhou, Haoxin, et al. “Skyrmion Solids in Monolayer Graphene.” Nature Physics,
vol. 16, no. 2, Springer Nature, 2020, pp. 154–58, doi:10.1038/s41567-019-0729-8.
short: H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, A.F. Young, Nature Physics
16 (2020) 154–158.
date_created: 2022-01-28T12:04:09Z
date_published: 2020-02-01T00:00:00Z
date_updated: 2022-01-31T07:10:07Z
day: '01'
doi: 10.1038/s41567-019-0729-8
extern: '1'
external_id:
arxiv:
- '1904.11485'
intvolume: ' 16'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1904.11485
month: '02'
oa: 1
oa_version: Preprint
page: 154-158
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Skyrmion solids in monolayer graphene
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 16
year: '2020'
...
---
_id: '11056'
abstract:
- lang: eng
text: Aging of the circulatory system correlates with the pathogenesis of a large
spectrum of diseases. However, it is largely unknown which factors drive the age-dependent
or pathological decline of the vasculature and how vascular defects relate to
tissue aging. The goal of the study is to design a multianalytical approach to
identify how the cellular microenvironment (i.e., fibroblasts) and serum from
healthy donors of different ages or Alzheimer disease (AD) patients can modulate
the functionality of organ-specific vascular endothelial cells (VECs). Long-living
human microvascular networks embedding VECs and fibroblasts from skin biopsies
are generated. RNA-seq, secretome analyses, and microfluidic assays demonstrate
that fibroblasts from young donors restore the functionality of aged endothelial
cells, an effect also achieved by serum from young donors. New biomarkers of vascular
aging are validated in human biopsies and it is shown that young serum induces
angiopoietin-like-4, which can restore compromised vascular barriers. This strategy
is then employed to characterize transcriptional/functional changes induced on
the blood–brain barrier by AD serum, demonstrating the importance of PTP4A3 in
the regulation of permeability. Features of vascular degeneration during aging
and AD are recapitulated, and a tool to identify novel biomarkers that can be
exploited to develop future therapeutics modulating vascular function is established.
article_number: '2000044'
article_processing_charge: No
article_type: original
author:
- first_name: Simone
full_name: Bersini, Simone
last_name: Bersini
- first_name: Rafael
full_name: Arrojo e Drigo, Rafael
last_name: Arrojo e Drigo
- first_name: Ling
full_name: Huang, Ling
last_name: Huang
- first_name: Maxim N.
full_name: Shokhirev, Maxim N.
last_name: Shokhirev
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Bersini S, Arrojo e Drigo R, Huang L, Shokhirev MN, Hetzer M. Transcriptional
and functional changes of the human microvasculature during physiological aging
and Alzheimer disease. Advanced Biosystems. 2020;4(5). doi:10.1002/adbi.202000044
apa: Bersini, S., Arrojo e Drigo, R., Huang, L., Shokhirev, M. N., & Hetzer,
M. (2020). Transcriptional and functional changes of the human microvasculature
during physiological aging and Alzheimer disease. Advanced Biosystems.
Wiley. https://doi.org/10.1002/adbi.202000044
chicago: Bersini, Simone, Rafael Arrojo e Drigo, Ling Huang, Maxim N. Shokhirev,
and Martin Hetzer. “Transcriptional and Functional Changes of the Human Microvasculature
during Physiological Aging and Alzheimer Disease.” Advanced Biosystems.
Wiley, 2020. https://doi.org/10.1002/adbi.202000044.
ieee: S. Bersini, R. Arrojo e Drigo, L. Huang, M. N. Shokhirev, and M. Hetzer, “Transcriptional
and functional changes of the human microvasculature during physiological aging
and Alzheimer disease,” Advanced Biosystems, vol. 4, no. 5. Wiley, 2020.
ista: Bersini S, Arrojo e Drigo R, Huang L, Shokhirev MN, Hetzer M. 2020. Transcriptional
and functional changes of the human microvasculature during physiological aging
and Alzheimer disease. Advanced Biosystems. 4(5), 2000044.
mla: Bersini, Simone, et al. “Transcriptional and Functional Changes of the Human
Microvasculature during Physiological Aging and Alzheimer Disease.” Advanced
Biosystems, vol. 4, no. 5, 2000044, Wiley, 2020, doi:10.1002/adbi.202000044.
short: S. Bersini, R. Arrojo e Drigo, L. Huang, M.N. Shokhirev, M. Hetzer, Advanced
Biosystems 4 (2020).
date_created: 2022-04-07T07:43:57Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2022-07-18T08:30:48Z
day: '01'
ddc:
- '570'
doi: 10.1002/adbi.202000044
extern: '1'
external_id:
pmid:
- '32402127'
file:
- access_level: open_access
checksum: 5584d9a1609812dc75c02ce1e35d2ec0
content_type: application/pdf
creator: dernst
date_created: 2022-04-08T07:06:05Z
date_updated: 2022-04-08T07:06:05Z
file_id: '11134'
file_name: 2020_AdvancedBiosystems_Bersini.pdf
file_size: 2490829
relation: main_file
success: 1
file_date_updated: 2022-04-08T07:06:05Z
has_accepted_license: '1'
intvolume: ' 4'
issue: '5'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
- Biomedical Engineering
- Biomaterials
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Advanced Biosystems
publication_identifier:
issn:
- 2366-7478
- 2366-7478
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Transcriptional and functional changes of the human microvasculature during
physiological aging and Alzheimer disease
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 4
year: '2020'
...
---
_id: '11055'
abstract:
- lang: eng
text: Vascular dysfunctions are a common feature of multiple age-related diseases.
However, modeling healthy and pathological aging of the human vasculature represents
an unresolved experimental challenge. Here, we generated induced vascular endothelial
cells (iVECs) and smooth muscle cells (iSMCs) by direct reprogramming of healthy
human fibroblasts from donors of different ages and Hutchinson-Gilford Progeria
Syndrome (HGPS) patients. iVECs induced from old donors revealed upregulation
of GSTM1 and PALD1, genes linked to oxidative stress, inflammation and endothelial
junction stability, as vascular aging markers. A functional assay performed on
PALD1 KD VECs demonstrated a recovery in vascular permeability. We found that
iSMCs from HGPS donors overexpressed bone morphogenetic protein (BMP)−4, which
plays a key role in both vascular calcification and endothelial barrier damage
observed in HGPS. Strikingly, BMP4 concentrations are higher in serum from HGPS
vs. age-matched mice. Furthermore, targeting BMP4 with blocking antibody recovered
the functionality of the vascular barrier in vitro, hence representing a potential
future therapeutic strategy to limit cardiovascular dysfunction in HGPS. These
results show that iVECs and iSMCs retain disease-related signatures, allowing
modeling of vascular aging and HGPS in vitro.
article_number: e54383
article_processing_charge: No
article_type: original
author:
- first_name: Simone
full_name: Bersini, Simone
last_name: Bersini
- first_name: Roberta
full_name: Schulte, Roberta
last_name: Schulte
- first_name: Ling
full_name: Huang, Ling
last_name: Huang
- first_name: Hannah
full_name: Tsai, Hannah
last_name: Tsai
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. Direct reprogramming of human
smooth muscle and vascular endothelial cells reveals defects associated with aging
and Hutchinson-Gilford progeria syndrome. eLife. 2020;9. doi:10.7554/elife.54383
apa: Bersini, S., Schulte, R., Huang, L., Tsai, H., & Hetzer, M. (2020). Direct
reprogramming of human smooth muscle and vascular endothelial cells reveals defects
associated with aging and Hutchinson-Gilford progeria syndrome. ELife.
eLife Sciences Publications. https://doi.org/10.7554/elife.54383
chicago: Bersini, Simone, Roberta Schulte, Ling Huang, Hannah Tsai, and Martin Hetzer.
“Direct Reprogramming of Human Smooth Muscle and Vascular Endothelial Cells Reveals
Defects Associated with Aging and Hutchinson-Gilford Progeria Syndrome.” ELife.
eLife Sciences Publications, 2020. https://doi.org/10.7554/elife.54383.
ieee: S. Bersini, R. Schulte, L. Huang, H. Tsai, and M. Hetzer, “Direct reprogramming
of human smooth muscle and vascular endothelial cells reveals defects associated
with aging and Hutchinson-Gilford progeria syndrome,” eLife, vol. 9. eLife
Sciences Publications, 2020.
ista: Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. 2020. Direct reprogramming
of human smooth muscle and vascular endothelial cells reveals defects associated
with aging and Hutchinson-Gilford progeria syndrome. eLife. 9, e54383.
mla: Bersini, Simone, et al. “Direct Reprogramming of Human Smooth Muscle and Vascular
Endothelial Cells Reveals Defects Associated with Aging and Hutchinson-Gilford
Progeria Syndrome.” ELife, vol. 9, e54383, eLife Sciences Publications,
2020, doi:10.7554/elife.54383.
short: S. Bersini, R. Schulte, L. Huang, H. Tsai, M. Hetzer, ELife 9 (2020).
date_created: 2022-04-07T07:43:48Z
date_published: 2020-09-08T00:00:00Z
date_updated: 2022-07-18T08:30:37Z
day: '08'
ddc:
- '570'
doi: 10.7554/elife.54383
extern: '1'
external_id:
pmid:
- '32896271'
file:
- access_level: open_access
checksum: f8b3821349a194050be02570d8fe7d4b
content_type: application/pdf
creator: dernst
date_created: 2022-04-08T06:53:10Z
date_updated: 2022-04-08T06:53:10Z
file_id: '11132'
file_name: 2020_eLife_Bersini.pdf
file_size: 4399825
relation: main_file
success: 1
file_date_updated: 2022-04-08T06:53:10Z
has_accepted_license: '1'
intvolume: ' 9'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Direct reprogramming of human smooth muscle and vascular endothelial cells
reveals defects associated with aging and Hutchinson-Gilford progeria syndrome
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 9
year: '2020'
...
---
_id: '11054'
abstract:
- lang: eng
text: In recent years, the nuclear pore complex (NPC) has emerged as a key player
in genome regulation and cellular homeostasis. New discoveries have revealed that
the NPC has multiple cellular functions besides mediating the molecular exchange
between the nucleus and the cytoplasm. In this review, we discuss non-transport
aspects of the NPC focusing on the NPC-genome interaction, the extreme longevity
of the NPC proteins, and NPC dysfunction in age-related diseases. The examples
summarized herein demonstrate that the NPC, which first evolved to enable the
biochemical communication between the nucleus and the cytoplasm, now doubles as
the gatekeeper of cellular identity and aging.
article_processing_charge: No
article_type: review
author:
- first_name: Ukrae H.
full_name: Cho, Ukrae H.
last_name: Cho
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: 'Cho UH, Hetzer M. Nuclear periphery takes center stage: The role of nuclear
pore complexes in cell identity and aging. Neuron. 2020;106(6):899-911.
doi:10.1016/j.neuron.2020.05.031'
apa: 'Cho, U. H., & Hetzer, M. (2020). Nuclear periphery takes center stage:
The role of nuclear pore complexes in cell identity and aging. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2020.05.031'
chicago: 'Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage:
The Role of Nuclear Pore Complexes in Cell Identity and Aging.” Neuron.
Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.05.031.'
ieee: 'U. H. Cho and M. Hetzer, “Nuclear periphery takes center stage: The role
of nuclear pore complexes in cell identity and aging,” Neuron, vol. 106,
no. 6. Elsevier, pp. 899–911, 2020.'
ista: 'Cho UH, Hetzer M. 2020. Nuclear periphery takes center stage: The role of
nuclear pore complexes in cell identity and aging. Neuron. 106(6), 899–911.'
mla: 'Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage: The
Role of Nuclear Pore Complexes in Cell Identity and Aging.” Neuron, vol.
106, no. 6, Elsevier, 2020, pp. 899–911, doi:10.1016/j.neuron.2020.05.031.'
short: U.H. Cho, M. Hetzer, Neuron 106 (2020) 899–911.
date_created: 2022-04-07T07:43:36Z
date_published: 2020-06-17T00:00:00Z
date_updated: 2022-07-18T08:29:35Z
day: '17'
doi: 10.1016/j.neuron.2020.05.031
extern: '1'
external_id:
pmid:
- '32553207'
intvolume: ' 106'
issue: '6'
keyword:
- General Neuroscience
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2020.05.031
month: '06'
oa: 1
oa_version: Published Version
page: 899-911
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Nuclear periphery takes center stage: The role of nuclear pore complexes in
cell identity and aging'
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 106
year: '2020'
...
---
_id: '11057'
abstract:
- lang: eng
text: During mitosis, transcription of genomic DNA is dramatically reduced, before
it is reactivated during nuclear reformation in anaphase/telophase. Many aspects
of the underlying principles that mediate transcriptional memory and reactivation
in the daughter cells remain unclear. Here, we used ChIP-seq on synchronized cells
at different stages after mitosis to generate genome-wide maps of histone modifications.
Combined with EU-RNA-seq and Hi-C analyses, we found that during prometaphase,
promoters, enhancers, and insulators retain H3K4me3 and H3K4me1, while losing
H3K27ac. Enhancers globally retaining mitotic H3K4me1 or locally retaining mitotic
H3K27ac are associated with cell type-specific genes and their transcription factors
for rapid transcriptional activation. As cells exit mitosis, promoters regain
H3K27ac, which correlates with transcriptional reactivation. Insulators also gain
H3K27ac and CCCTC-binding factor (CTCF) in anaphase/telophase. This increase of
H3K27ac in anaphase/telophase is required for posttranscriptional activation and
may play a role in the establishment of topologically associating domains (TADs).
Together, our results suggest that the genome is reorganized in a sequential order,
in which histone methylations occur first in prometaphase, histone acetylation,
and CTCF in anaphase/telophase, transcription in cytokinesis, and long-range chromatin
interactions in early G1. We thus provide insights into the histone modification
landscape that allows faithful reestablishment of the transcriptional program
and TADs during cell division.
article_processing_charge: No
article_type: original
author:
- first_name: Hyeseon
full_name: Kang, Hyeseon
last_name: Kang
- first_name: Maxim N.
full_name: Shokhirev, Maxim N.
last_name: Shokhirev
- first_name: Zhichao
full_name: Xu, Zhichao
last_name: Xu
- first_name: Sahaana
full_name: Chandran, Sahaana
last_name: Chandran
- first_name: Jesse R.
full_name: Dixon, Jesse R.
last_name: Dixon
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer M. Dynamic regulation
of histone modifications and long-range chromosomal interactions during postmitotic
transcriptional reactivation. Genes & Development. 2020;34(13-14):913-930.
doi:10.1101/gad.335794.119
apa: Kang, H., Shokhirev, M. N., Xu, Z., Chandran, S., Dixon, J. R., & Hetzer,
M. (2020). Dynamic regulation of histone modifications and long-range chromosomal
interactions during postmitotic transcriptional reactivation. Genes & Development.
Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.335794.119
chicago: Kang, Hyeseon, Maxim N. Shokhirev, Zhichao Xu, Sahaana Chandran, Jesse
R. Dixon, and Martin Hetzer. “Dynamic Regulation of Histone Modifications and
Long-Range Chromosomal Interactions during Postmitotic Transcriptional Reactivation.”
Genes & Development. Cold Spring Harbor Laboratory Press, 2020. https://doi.org/10.1101/gad.335794.119.
ieee: H. Kang, M. N. Shokhirev, Z. Xu, S. Chandran, J. R. Dixon, and M. Hetzer,
“Dynamic regulation of histone modifications and long-range chromosomal interactions
during postmitotic transcriptional reactivation,” Genes & Development,
vol. 34, no. 13–14. Cold Spring Harbor Laboratory Press, pp. 913–930, 2020.
ista: Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer M. 2020. Dynamic
regulation of histone modifications and long-range chromosomal interactions during
postmitotic transcriptional reactivation. Genes & Development. 34(13–14),
913–930.
mla: Kang, Hyeseon, et al. “Dynamic Regulation of Histone Modifications and Long-Range
Chromosomal Interactions during Postmitotic Transcriptional Reactivation.” Genes
& Development, vol. 34, no. 13–14, Cold Spring Harbor Laboratory Press,
2020, pp. 913–30, doi:10.1101/gad.335794.119.
short: H. Kang, M.N. Shokhirev, Z. Xu, S. Chandran, J.R. Dixon, M. Hetzer, Genes
& Development 34 (2020) 913–930.
date_created: 2022-04-07T07:44:09Z
date_published: 2020-04-28T00:00:00Z
date_updated: 2022-07-18T08:31:08Z
day: '28'
ddc:
- '570'
doi: 10.1101/gad.335794.119
extern: '1'
external_id:
pmid:
- '32499403'
file:
- access_level: open_access
checksum: 84e92d40e67936c739628315c238daf9
content_type: application/pdf
creator: dernst
date_created: 2022-04-08T07:12:33Z
date_updated: 2022-04-08T07:12:33Z
file_id: '11136'
file_name: 2020_GenesDevelopment_Kang.pdf
file_size: 4406772
relation: main_file
success: 1
file_date_updated: 2022-04-08T07:12:33Z
has_accepted_license: '1'
intvolume: ' 34'
issue: 13-14
keyword:
- Developmental Biology
- Genetics
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 913-930
pmid: 1
publication: Genes & Development
publication_identifier:
issn:
- 0890-9369
- 1549-5477
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic regulation of histone modifications and long-range chromosomal interactions
during postmitotic transcriptional reactivation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 34
year: '2020'
...
---
_id: '11058'
abstract:
- lang: eng
text: Nucleoporin 93 (Nup93) expression inversely correlates with the survival of
triple-negative breast cancer patients. However, our knowledge of Nup93 function
in breast cancer besides its role as structural component of the nuclear pore
complex is not understood. Combination of functional assays and genetic analyses
suggested that chromatin interaction of Nup93 partially modulates the expression
of genes associated with actin cytoskeleton remodeling and epithelial to mesenchymal
transition, resulting in impaired invasion of triple-negative, claudin-low breast
cancer cells. Nup93 depletion induced stress fiber formation associated with reduced
cell migration/proliferation and impaired expression of mesenchymal-like genes.
Silencing LIMCH1, a gene responsible for actin cytoskeleton remodeling and up-regulated
upon Nup93 depletion, partially restored the invasive phenotype of cancer cells.
Loss of Nup93 led to significant defects in tumor establishment/propagation in
vivo, whereas patient samples revealed that high Nup93 and low LIMCH1 expression
correlate with late tumor stage. Our approach identified Nup93 as contributor
of triple-negative, claudin-low breast cancer cell invasion and paves the way
to study the role of nuclear envelope proteins during breast cancer tumorigenesis.
article_number: e201900623
article_processing_charge: No
article_type: original
author:
- first_name: Simone
full_name: Bersini, Simone
last_name: Bersini
- first_name: Nikki K
full_name: Lytle, Nikki K
last_name: Lytle
- first_name: Roberta
full_name: Schulte, Roberta
last_name: Schulte
- first_name: Ling
full_name: Huang, Ling
last_name: Huang
- first_name: Geoffrey M
full_name: Wahl, Geoffrey M
last_name: Wahl
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. Nup93 regulates
breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling.
Life Science Alliance. 2020;3(1). doi:10.26508/lsa.201900623
apa: Bersini, S., Lytle, N. K., Schulte, R., Huang, L., Wahl, G. M., & Hetzer,
M. (2020). Nup93 regulates breast tumor growth by modulating cell proliferation
and actin cytoskeleton remodeling. Life Science Alliance. Life Science
Alliance. https://doi.org/10.26508/lsa.201900623
chicago: Bersini, Simone, Nikki K Lytle, Roberta Schulte, Ling Huang, Geoffrey M
Wahl, and Martin Hetzer. “Nup93 Regulates Breast Tumor Growth by Modulating Cell
Proliferation and Actin Cytoskeleton Remodeling.” Life Science Alliance.
Life Science Alliance, 2020. https://doi.org/10.26508/lsa.201900623.
ieee: S. Bersini, N. K. Lytle, R. Schulte, L. Huang, G. M. Wahl, and M. Hetzer,
“Nup93 regulates breast tumor growth by modulating cell proliferation and actin
cytoskeleton remodeling,” Life Science Alliance, vol. 3, no. 1. Life Science
Alliance, 2020.
ista: Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. 2020. Nup93 regulates
breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling.
Life Science Alliance. 3(1), e201900623.
mla: Bersini, Simone, et al. “Nup93 Regulates Breast Tumor Growth by Modulating
Cell Proliferation and Actin Cytoskeleton Remodeling.” Life Science Alliance,
vol. 3, no. 1, e201900623, Life Science Alliance, 2020, doi:10.26508/lsa.201900623.
short: S. Bersini, N.K. Lytle, R. Schulte, L. Huang, G.M. Wahl, M. Hetzer, Life
Science Alliance 3 (2020).
date_created: 2022-04-07T07:44:18Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2022-07-18T08:31:20Z
day: '01'
ddc:
- '570'
doi: 10.26508/lsa.201900623
extern: '1'
external_id:
pmid:
- '31959624'
file:
- access_level: open_access
checksum: 3bf33e7e93bef7823287807206b69b38
content_type: application/pdf
creator: dernst
date_created: 2022-04-08T07:33:01Z
date_updated: 2022-04-08T07:33:01Z
file_id: '11137'
file_name: 2020_LifeScienceAlliance_Bersini.pdf
file_size: 2653960
relation: main_file
success: 1
file_date_updated: 2022-04-08T07:33:01Z
has_accepted_license: '1'
intvolume: ' 3'
issue: '1'
keyword:
- Health
- Toxicology and Mutagenesis
- Plant Science
- Biochemistry
- Genetics and Molecular Biology (miscellaneous)
- Ecology
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Life Science Alliance
publication_identifier:
issn:
- 2575-1077
publication_status: published
publisher: Life Science Alliance
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nup93 regulates breast tumor growth by modulating cell proliferation and actin
cytoskeleton remodeling
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 3
year: '2020'
...
---
_id: '11503'
abstract:
- lang: eng
text: "Context. The Lyα emitter (LAE) fraction, XLAE, is a potentially powerful
probe of the evolution of the intergalactic neutral hydrogen gas fraction. However,
uncertainties in the measurement of XLAE are still under debate.\r\nAims. Thanks
to deep data obtained with the integral field spectrograph Multi Unit Spectroscopic
Explorer (MUSE), we can measure the evolution of the LAE fraction homogeneously
over a wide redshift range of z ≈ 3–6 for UV-faint galaxies (down to UV magnitudes
of M1500 ≈ −17.75). This is a significantly fainter range than in former studies
(M1500 ≤ −18.75) and it allows us to probe the bulk of the population of high-redshift
star-forming galaxies.\r\nMethods. We constructed a UV-complete photometric-redshift
sample following UV luminosity functions and measured the Lyα emission with MUSE
using the latest (second) data release from the MUSE Hubble Ultra Deep Field Survey.\r\nResults.
We derived the redshift evolution of XLAE for M1500 ∈ [ − 21.75; −17.75] for the
first time with a equivalent width range EW(Lyα) ≥ 65 Å and found low values of
XLAE ≲ 30% at z ≲ 6. The best-fit linear relation is XLAE = 0.07+0.06−0.03z −
0.22+0.12−0.24. For M1500 ∈ [ − 20.25; −18.75] and EW(Lyα) ≥ 25 Å, our XLAE values
are consistent with those in the literature within 1σ at z ≲ 5, but our median
values are systematically lower than reported values over the whole redshift range.
In addition, we do not find a significant dependence of XLAE on M1500 for EW(Lyα)
≥ 50 Å at z ≈ 3–4, in contrast with previous work. The differences in XLAE mainly
arise from selection biases for Lyman Break Galaxies (LBGs) in the literature:
UV-faint LBGs are more easily selected if they have strong Lyα emission, hence
XLAE is biased towards higher values when those samples are used.\r\nConclusions.
Our results suggest either a lower increase of XLAE towards z ≈ 6 than previously
suggested, or even a turnover of XLAE at z ≈ 5.5, which may be the signature of
a late or patchy reionization process. We compared our results with predictions
from a cosmological galaxy evolution model. We find that a model with a bursty
star formation (SF) can reproduce our observed LAE fractions much better than
models where SF is a smooth function of time."
acknowledgement: We thank the anonymous referee for constructive comments and suggestions.
We would like to express our gratitude to Stephane De Barros and Pablo Arrabal Haro
for kindly providing their data plotted in Figs. 1, 2, and 8. We are grateful to
Kazuhiro Shimasaku, Masami Ouchi, Rieko Momose, Daniel Schaerer, Hidenobu Yajima,
Taku Okamura, Makoto Ando, and Hinako Goto for giving insightful comments and suggestions.
This work is based on observations taken by VLT, which is operated by European Southern
Observatory. This research made use of Astropy (http://www.astropy.org), which is
a community-developed core Python package for Astronomy (Astropy Collaboration 2013,
2018), MARZ, MPDAF, and matplotlib (Hunter 2007). H.K. acknowledges support from
Japan Society for the Promotion of Science (JSPS) through the JSPS Research Fellowship
for Young Scientists and Overseas Challenge Program for Young Researchers. AV acknowledges
support from the ERC starting grant 757258-TRIPLE and the SNF Professorship 176808-TRIPLE.
This work was supported by the project FOGHAR (Agence Nationale de la Recherche,
ANR-13-BS05-0010-02). JB acknowledges support from the ORAGE project from the Agence
Nationale de la Recherche under grant ANR-14-CE33-0016-03. JR acknowledges support
from the ERC starting grant 336736-CALENDS. T. H. acknowledges supports by the Grant-inAid
for Scientic Research 19J01620.
article_number: A12
article_processing_charge: No
article_type: original
author:
- first_name: Haruka
full_name: Kusakabe, Haruka
last_name: Kusakabe
- first_name: Jérémy
full_name: Blaizot, Jérémy
last_name: Blaizot
- first_name: Thibault
full_name: Garel, Thibault
last_name: Garel
- first_name: Anne
full_name: Verhamme, Anne
last_name: Verhamme
- first_name: Roland
full_name: Bacon, Roland
last_name: Bacon
- first_name: Johan
full_name: Richard, Johan
last_name: Richard
- first_name: Takuya
full_name: Hashimoto, Takuya
last_name: Hashimoto
- first_name: Hanae
full_name: Inami, Hanae
last_name: Inami
- first_name: Simon
full_name: Conseil, Simon
last_name: Conseil
- first_name: Bruno
full_name: Guiderdoni, Bruno
last_name: Guiderdoni
- first_name: Alyssa B.
full_name: Drake, Alyssa B.
last_name: Drake
- first_name: Edmund
full_name: Christian Herenz, Edmund
last_name: Christian Herenz
- first_name: Joop
full_name: Schaye, Joop
last_name: Schaye
- first_name: Pascal
full_name: Oesch, Pascal
last_name: Oesch
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Raffaella
full_name: Anna Marino, Raffaella
last_name: Anna Marino
- first_name: Kasper
full_name: Borello Schmidt, Kasper
last_name: Borello Schmidt
- first_name: Roser
full_name: Pelló, Roser
last_name: Pelló
- first_name: Michael
full_name: Maseda, Michael
last_name: Maseda
- first_name: Floriane
full_name: Leclercq, Floriane
last_name: Leclercq
- first_name: Josephine
full_name: Kerutt, Josephine
last_name: Kerutt
- first_name: Guillaume
full_name: Mahler, Guillaume
last_name: Mahler
citation:
ama: 'Kusakabe H, Blaizot J, Garel T, et al. The MUSE Hubble Ultra Deep Field Survey:
XIV. Evolution of the Lyα emitter fraction from z = 3 to z = 6. Astronomy &
Astrophysics. 2020;638. doi:10.1051/0004-6361/201937340'
apa: 'Kusakabe, H., Blaizot, J., Garel, T., Verhamme, A., Bacon, R., Richard, J.,
… Mahler, G. (2020). The MUSE Hubble Ultra Deep Field Survey: XIV. Evolution of
the Lyα emitter fraction from z = 3 to z = 6. Astronomy & Astrophysics.
EDP Sciences. https://doi.org/10.1051/0004-6361/201937340'
chicago: 'Kusakabe, Haruka, Jérémy Blaizot, Thibault Garel, Anne Verhamme, Roland
Bacon, Johan Richard, Takuya Hashimoto, et al. “The MUSE Hubble Ultra Deep Field
Survey: XIV. Evolution of the Lyα Emitter Fraction from z = 3 to z = 6.” Astronomy
& Astrophysics. EDP Sciences, 2020. https://doi.org/10.1051/0004-6361/201937340.'
ieee: 'H. Kusakabe et al., “The MUSE Hubble Ultra Deep Field Survey: XIV.
Evolution of the Lyα emitter fraction from z = 3 to z = 6,” Astronomy &
Astrophysics, vol. 638. EDP Sciences, 2020.'
ista: 'Kusakabe H, Blaizot J, Garel T, Verhamme A, Bacon R, Richard J, Hashimoto
T, Inami H, Conseil S, Guiderdoni B, Drake AB, Christian Herenz E, Schaye J, Oesch
P, Matthee JJ, Anna Marino R, Borello Schmidt K, Pelló R, Maseda M, Leclercq F,
Kerutt J, Mahler G. 2020. The MUSE Hubble Ultra Deep Field Survey: XIV. Evolution
of the Lyα emitter fraction from z = 3 to z = 6. Astronomy & Astrophysics.
638, A12.'
mla: 'Kusakabe, Haruka, et al. “The MUSE Hubble Ultra Deep Field Survey: XIV. Evolution
of the Lyα Emitter Fraction from z = 3 to z = 6.” Astronomy & Astrophysics,
vol. 638, A12, EDP Sciences, 2020, doi:10.1051/0004-6361/201937340.'
short: H. Kusakabe, J. Blaizot, T. Garel, A. Verhamme, R. Bacon, J. Richard, T.
Hashimoto, H. Inami, S. Conseil, B. Guiderdoni, A.B. Drake, E. Christian Herenz,
J. Schaye, P. Oesch, J.J. Matthee, R. Anna Marino, K. Borello Schmidt, R. Pelló,
M. Maseda, F. Leclercq, J. Kerutt, G. Mahler, Astronomy & Astrophysics 638
(2020).
date_created: 2022-07-06T09:50:48Z
date_published: 2020-06-03T00:00:00Z
date_updated: 2022-07-19T09:35:20Z
day: '03'
doi: 10.1051/0004-6361/201937340
extern: '1'
external_id:
arxiv:
- '2003.12083'
intvolume: ' 638'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'dark ages / reionization / first stars / early Universe / cosmology: observations
/ galaxies: evolution / galaxies: high-redshift / intergalactic medium'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2003.12083
month: '06'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The MUSE Hubble Ultra Deep Field Survey: XIV. Evolution of the Lyα emitter
fraction from z = 3 to z = 6'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 638
year: '2020'
...
---
_id: '11504'
abstract:
- lang: eng
text: We present spatially resolved maps of six individually-detected Lyman α haloes
(LAHs) as well as a first statistical analysis of the Lyman α (Lyα) spectral signature
in the circum-galactic medium of high-redshift star-forming galaxies (−17.5 >
MUV > −21.5) using the Multi-Unit Spectroscopic Explorer. Our resolved spectroscopic
analysis of the LAHs reveals significant intrahalo variations of the Lyα line
profile. Using a three-dimensional two-component model for the Lyα emission, we
measured the full width at half maximum (FWHM), the peak velocity shift, and the
asymmetry of the Lyα line in the core and in the halo of 19 galaxies. We find
that the Lyα line shape is statistically different in the halo compared to the
core (in terms of width, peak wavelength, and asymmetry) for ≈40% of our galaxies.
Similarly to object-by-object based studies and a recent resolved study using
lensing, we find a correlation between the peak velocity shift and the width of
the Lyα line both at the interstellar and circum-galactic scales. This trend has
been predicted by radiative transfer simulations of galactic winds as a result
of resonant scattering in outflows. While there is a lack of correlation between
the spectral properties and the spatial scale lengths of our LAHs, we find a correlation
between the width of the line in the LAH and the halo flux fraction. Interestingly,
UV bright galaxies (MUV < −20) show broader, more redshifted, and less asymmetric
Lyα lines in their haloes. The most significant correlation found is for the FWHM
of the line and the UV continuum slope of the galaxy, suggesting that the redder
galaxies have broader Lyα lines. The generally broad and red line shapes found
in the halo component suggest that the Lyα haloes are powered either by scattering
processes through an outflowing medium, fluorescent emission from outflowing cold
clumps of gas, or a mix of both. Considering the large diversity of the Lyα line
profiles observed in our sample and the lack of strong correlation, the interpretation
of our results is still broadly open and underlines the need for realistic spatially
resolved models of the LAHs.
acknowledgement: F.L., R.B., and S.C. acknowledge support from the ERC advanced grant
339659-MUSICOS. F.L., T.G., H.K., and A.V. acknowledge support from the ERC starting
grant ERC-757258-TRIPLE. A.C. and J.R. acknowledge support from the ERC starting
grant 336736-CALENDS. J.B. acknowledges support by FCT/MCTES through national funds
(PID-DAC) by grant UID/FIS/04434/2019 and through Investigador FCT Contract No.IF/01654/2014/CP1215/CT0003.
T.H. was supported by Leading Initiative for Excellent Young Researchers, MEXT,
Japan.
article_number: A82
article_processing_charge: No
article_type: original
author:
- first_name: Floriane
full_name: Leclercq, Floriane
last_name: Leclercq
- first_name: Roland
full_name: Bacon, Roland
last_name: Bacon
- first_name: Anne
full_name: Verhamme, Anne
last_name: Verhamme
- first_name: Thibault
full_name: Garel, Thibault
last_name: Garel
- first_name: Jérémy
full_name: Blaizot, Jérémy
last_name: Blaizot
- first_name: Jarle
full_name: Brinchmann, Jarle
last_name: Brinchmann
- first_name: Sebastiano
full_name: Cantalupo, Sebastiano
last_name: Cantalupo
- first_name: Adélaïde
full_name: Claeyssens, Adélaïde
last_name: Claeyssens
- first_name: Simon
full_name: Conseil, Simon
last_name: Conseil
- first_name: Thierry
full_name: Contini, Thierry
last_name: Contini
- first_name: Takuya
full_name: Hashimoto, Takuya
last_name: Hashimoto
- first_name: Edmund Christian
full_name: Herenz, Edmund Christian
last_name: Herenz
- first_name: Haruka
full_name: Kusakabe, Haruka
last_name: Kusakabe
- first_name: Raffaella Anna
full_name: Marino, Raffaella Anna
last_name: Marino
- first_name: Michael
full_name: Maseda, Michael
last_name: Maseda
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Peter
full_name: Mitchell, Peter
last_name: Mitchell
- first_name: Gabriele
full_name: Pezzulli, Gabriele
last_name: Pezzulli
- first_name: Johan
full_name: Richard, Johan
last_name: Richard
- first_name: Kasper Borello
full_name: Schmidt, Kasper Borello
last_name: Schmidt
- first_name: Lutz
full_name: Wisotzki, Lutz
last_name: Wisotzki
citation:
ama: 'Leclercq F, Bacon R, Verhamme A, et al. The MUSE Hubble Ultra Deep field survey:
XIII. Spatially resolved spectral properties of Lyman α haloes around star-forming
galaxies at z > 3. Astronomy & Astrophysics. 2020;635. doi:10.1051/0004-6361/201937339'
apa: 'Leclercq, F., Bacon, R., Verhamme, A., Garel, T., Blaizot, J., Brinchmann,
J., … Wisotzki, L. (2020). The MUSE Hubble Ultra Deep field survey: XIII. Spatially
resolved spectral properties of Lyman α haloes around star-forming galaxies at
z > 3. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/201937339'
chicago: 'Leclercq, Floriane, Roland Bacon, Anne Verhamme, Thibault Garel, Jérémy
Blaizot, Jarle Brinchmann, Sebastiano Cantalupo, et al. “The MUSE Hubble Ultra
Deep Field Survey: XIII. Spatially Resolved Spectral Properties of Lyman α Haloes
around Star-Forming Galaxies at z > 3.” Astronomy & Astrophysics.
EDP Sciences, 2020. https://doi.org/10.1051/0004-6361/201937339.'
ieee: 'F. Leclercq et al., “The MUSE Hubble Ultra Deep field survey: XIII.
Spatially resolved spectral properties of Lyman α haloes around star-forming galaxies
at z > 3,” Astronomy & Astrophysics, vol. 635. EDP Sciences, 2020.'
ista: 'Leclercq F, Bacon R, Verhamme A, Garel T, Blaizot J, Brinchmann J, Cantalupo
S, Claeyssens A, Conseil S, Contini T, Hashimoto T, Herenz EC, Kusakabe H, Marino
RA, Maseda M, Matthee JJ, Mitchell P, Pezzulli G, Richard J, Schmidt KB, Wisotzki
L. 2020. The MUSE Hubble Ultra Deep field survey: XIII. Spatially resolved spectral
properties of Lyman α haloes around star-forming galaxies at z > 3. Astronomy
& Astrophysics. 635, A82.'
mla: 'Leclercq, Floriane, et al. “The MUSE Hubble Ultra Deep Field Survey: XIII.
Spatially Resolved Spectral Properties of Lyman α Haloes around Star-Forming Galaxies
at z > 3.” Astronomy & Astrophysics, vol. 635, A82, EDP Sciences,
2020, doi:10.1051/0004-6361/201937339.'
short: F. Leclercq, R. Bacon, A. Verhamme, T. Garel, J. Blaizot, J. Brinchmann,
S. Cantalupo, A. Claeyssens, S. Conseil, T. Contini, T. Hashimoto, E.C. Herenz,
H. Kusakabe, R.A. Marino, M. Maseda, J.J. Matthee, P. Mitchell, G. Pezzulli, J.
Richard, K.B. Schmidt, L. Wisotzki, Astronomy & Astrophysics 635 (2020).
date_created: 2022-07-06T09:56:20Z
date_published: 2020-03-11T00:00:00Z
date_updated: 2022-07-19T09:36:58Z
day: '11'
doi: 10.1051/0004-6361/201937339
extern: '1'
external_id:
arxiv:
- '2002.05731'
intvolume: ' 635'
keyword:
- Space and Planetary Science
- 'Astronomy and Astrophysics galaxies: high-redshift / galaxies: formation / galaxies:
evolution / cosmology: observations'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2002.05731
month: '03'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The MUSE Hubble Ultra Deep field survey: XIII. Spatially resolved spectral
properties of Lyman α haloes around star-forming galaxies at z > 3'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 635
year: '2020'
...
---
_id: '11501'
abstract:
- lang: eng
text: We investigated the ultraviolet (UV) spectral properties of faint Lyman-α
emitters (LAEs) in the redshift range 2.9 ≤ z ≤ 4.6, and we provide material to
prepare future observations of the faint Universe. We used data from the MUSE
Hubble Ultra Deep Survey to construct mean rest-frame spectra of continuum-faint
(median MUV of −18 and down to MUV of −16), low stellar mass (median value of
108.4 M⊙ and down to 107 M⊙) LAEs at redshift z ≳ 3. We computed various averaged
spectra of LAEs, subsampled on the basis of their observational (e.g., Lyα strength,
UV magnitude and spectral slope) and physical (e.g., stellar mass and star-formation
rate) properties. We searched for UV spectral features other than Lyα, such as
higher ionization nebular emission lines and absorption features. We successfully
observed the O III]λ1666 and [C III]λ1907+C III]λ1909 collisionally excited emission
lines and the He IIλ1640 recombination feature, as well as the resonant C IVλλ1548,1551
doublet either in emission or P-Cygni. We compared the observed spectral properties
of the different mean spectra and find the emission lines to vary with the observational
and physical properties of the LAEs. In particular, the mean spectra of LAEs with
larger Lyα equivalent widths, fainter UV magnitudes, bluer UV spectral slopes,
and lower stellar masses show the strongest nebular emission. The line ratios
of these lines are similar to those measured in the spectra of local metal-poor
galaxies, while their equivalent widths are weaker compared to the handful of
extreme values detected in individual spectra of z > 2 galaxies. This suggests
that weak UV features are likely ubiquitous in high z, low-mass, and faint LAEs.
We publicly released the stacked spectra, as they can serve as empirical templates
for the design of future observations, such as those with the James Webb Space
Telescope and the Extremely Large Telescope.
acknowledgement: 'We thank Margherita Talia, Stéphane Charlot, Adele Plat and Alba
Vidal-García for helpful discussions. This work is supported by the ERC advanced
grant 339659-MUSICOS (R. Bacon). AF acknowledges the support from grant PRIN MIUR
2017 20173ML3WW. MVM and JP would like to thank the Leiden/ESA Astrophysics Program
for Summer Students (LEAPS) for funding at the outset of this project. FL, HK, and
AV acknowledge support from the ERC starting grant ERC-757258-TRIPLE. TH was supported
by Leading Initiative for Excellent Young Researchers, MEXT, Japan. JB acknowledges
support by FCT/MCTES through national funds by the grant UID/FIS/04434/2019, UIDB/04434/2020
and UIDP/04434/2020 and through the Investigador FCT Contract No. IF/01654/2014/CP1215/CT0003.
HI acknowledges support from JSPS KAKENHI Grant Number JP19K23462. We would also
like to thank the organizers and participants of the Leiden Lorentz Center workshop:
Revolutionary Spectroscopy of Today as a Springboard to Webb. This work made use
of several open source python packages: NUMPY (van der Walt et al. 2011), MATPLOTLIB
(Hunter 2007), ASTROPY (Astropy Collaboration 2013) and MPDAF (MUSE Python Data
Analysis Framework, Piqueras et al. 2019).'
article_number: A118
article_processing_charge: No
article_type: original
author:
- first_name: Anna
full_name: Feltre, Anna
last_name: Feltre
- first_name: Michael V.
full_name: Maseda, Michael V.
last_name: Maseda
- first_name: Roland
full_name: Bacon, Roland
last_name: Bacon
- first_name: Jayadev
full_name: Pradeep, Jayadev
last_name: Pradeep
- first_name: Floriane
full_name: Leclercq, Floriane
last_name: Leclercq
- first_name: Haruka
full_name: Kusakabe, Haruka
last_name: Kusakabe
- first_name: Lutz
full_name: Wisotzki, Lutz
last_name: Wisotzki
- first_name: Takuya
full_name: Hashimoto, Takuya
last_name: Hashimoto
- first_name: Kasper B.
full_name: Schmidt, Kasper B.
last_name: Schmidt
- first_name: Jeremy
full_name: Blaizot, Jeremy
last_name: Blaizot
- first_name: Jarle
full_name: Brinchmann, Jarle
last_name: Brinchmann
- first_name: Leindert
full_name: Boogaard, Leindert
last_name: Boogaard
- first_name: Sebastiano
full_name: Cantalupo, Sebastiano
last_name: Cantalupo
- first_name: David
full_name: Carton, David
last_name: Carton
- first_name: Hanae
full_name: Inami, Hanae
last_name: Inami
- first_name: Wolfram
full_name: Kollatschny, Wolfram
last_name: Kollatschny
- first_name: Raffaella A.
full_name: Marino, Raffaella A.
last_name: Marino
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Themiya
full_name: Nanayakkara, Themiya
last_name: Nanayakkara
- first_name: Johan
full_name: Richard, Johan
last_name: Richard
- first_name: Joop
full_name: Schaye, Joop
last_name: Schaye
- first_name: Laurence
full_name: Tresse, Laurence
last_name: Tresse
- first_name: Tanya
full_name: Urrutia, Tanya
last_name: Urrutia
- first_name: Anne
full_name: Verhamme, Anne
last_name: Verhamme
- first_name: Peter M.
full_name: Weilbacher, Peter M.
last_name: Weilbacher
citation:
ama: 'Feltre A, Maseda MV, Bacon R, et al. The MUSE Hubble Ultra Deep Field Survey:
XV. The mean rest-UV spectra of Lyα emitters at z > 3. Astronomy &
Astrophysics. 2020;641. doi:10.1051/0004-6361/202038133'
apa: 'Feltre, A., Maseda, M. V., Bacon, R., Pradeep, J., Leclercq, F., Kusakabe,
H., … Weilbacher, P. M. (2020). The MUSE Hubble Ultra Deep Field Survey: XV. The
mean rest-UV spectra of Lyα emitters at z > 3. Astronomy & Astrophysics.
EDP Sciences. https://doi.org/10.1051/0004-6361/202038133'
chicago: 'Feltre, Anna, Michael V. Maseda, Roland Bacon, Jayadev Pradeep, Floriane
Leclercq, Haruka Kusakabe, Lutz Wisotzki, et al. “The MUSE Hubble Ultra Deep Field
Survey: XV. The Mean Rest-UV Spectra of Lyα Emitters at z > 3.” Astronomy
& Astrophysics. EDP Sciences, 2020. https://doi.org/10.1051/0004-6361/202038133.'
ieee: 'A. Feltre et al., “The MUSE Hubble Ultra Deep Field Survey: XV. The
mean rest-UV spectra of Lyα emitters at z > 3,” Astronomy & Astrophysics,
vol. 641. EDP Sciences, 2020.'
ista: 'Feltre A, Maseda MV, Bacon R, Pradeep J, Leclercq F, Kusakabe H, Wisotzki
L, Hashimoto T, Schmidt KB, Blaizot J, Brinchmann J, Boogaard L, Cantalupo S,
Carton D, Inami H, Kollatschny W, Marino RA, Matthee JJ, Nanayakkara T, Richard
J, Schaye J, Tresse L, Urrutia T, Verhamme A, Weilbacher PM. 2020. The MUSE Hubble
Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα emitters at z >
3. Astronomy & Astrophysics. 641, A118.'
mla: 'Feltre, Anna, et al. “The MUSE Hubble Ultra Deep Field Survey: XV. The Mean
Rest-UV Spectra of Lyα Emitters at z > 3.” Astronomy & Astrophysics,
vol. 641, A118, EDP Sciences, 2020, doi:10.1051/0004-6361/202038133.'
short: A. Feltre, M.V. Maseda, R. Bacon, J. Pradeep, F. Leclercq, H. Kusakabe, L.
Wisotzki, T. Hashimoto, K.B. Schmidt, J. Blaizot, J. Brinchmann, L. Boogaard,
S. Cantalupo, D. Carton, H. Inami, W. Kollatschny, R.A. Marino, J.J. Matthee,
T. Nanayakkara, J. Richard, J. Schaye, L. Tresse, T. Urrutia, A. Verhamme, P.M.
Weilbacher, Astronomy & Astrophysics 641 (2020).
date_created: 2022-07-06T09:38:16Z
date_published: 2020-09-18T00:00:00Z
date_updated: 2022-07-19T09:35:43Z
day: '18'
doi: 10.1051/0004-6361/202038133
extern: '1'
external_id:
arxiv:
- '2007.01878'
intvolume: ' 641'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: evolution / galaxies: high-redshift / ISM: lines and bands / ultraviolet:
ISM / ultraviolet: galaxies'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2007.01878
month: '09'
oa: 1
oa_version: Published Version
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The MUSE Hubble Ultra Deep Field Survey: XV. The mean rest-UV spectra of Lyα
emitters at z > 3'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 641
year: '2020'
...
---
_id: '11513'
abstract:
- lang: eng
text: We report the spectroscopic confirmation of a new protocluster in the COSMOS
field at z ∼ 2.2, COSMOS Cluster 2.2 (CC2.2), originally identified as an overdensity
of narrowband selected Hα emitting candidates. With only two masks of Keck/MOSFIRE
near-IR spectroscopy in both H (∼1.47–1.81 μm) and K (∼1.92–2.40 μm) bands (∼1.5
hr each), we confirm 35 unique protocluster members with at least two emission
lines detected with S/N > 3. Combined with 12 extra members from the zCOSMOS-deep
spectroscopic survey (47 in total), we estimate a mean redshift and a line-of-sight
velocity dispersion of zmean = 2.23224 ± 0.00101 and σlos = 645 ± 69 km s−1 for
this protocluster, respectively. Assuming virialization and spherical symmetry
for the system, we estimate a total mass of Mvir ∼ (1–2) ×1014M⊙ for the structure.
We evaluate a number density enhancement of δg ∼ 7 for this system and we argue
that the structure is likely not fully virialized at z ∼ 2.2. However, in a spherical
collapse model, δg is expected to grow to a linear matter enhancement of ∼1.9
by z = 0, exceeding the collapse threshold of 1.69, and leading to a fully collapsed
and virialized Coma-type structure with a total mass of Mdyn(z = 0) ∼ 9.2 × 1014M⊙
by now. This observationally efficient confirmation suggests that large narrowband
emission-line galaxy surveys, when combined with ancillary photometric data, can
be used to effectively trace the large-scale structure and protoclusters at a
time when they are mostly dominated by star-forming galaxies.
acknowledgement: We are thankful to the anonymous referee for useful comments and
suggestions that improved the quality of this paper. B.D. acknowledges financial
support from NASA through the Astrophysics Data Analysis Program (ADAP), grant number
NNX12AE20G, and the National Science Foundation, grant number 1716907. B.D. is thankful
to Andreas Faisst, Laura Danly, and Matthew Burlando for their companionship during
the observing run. B.D. is grateful to the COSMOS team for their useful comments
during the team meeting in New York City 2019 May 14–17. A.R. research was made
possible by Friends of W. M. Keck Observatory who philanthropically support the
Keck Science Collaborative (KSC) fund. The observations presented herein were obtained
at the W. M. Keck Observatory (program C236, PI Scoville), which is operated as
a scientific partnership among the California Institute of Technology, the University
of California, and the National Aeronautics and Space Administration. The Observatory
was made possible by the generous financial support of the W. M. Keck Foundation.
The authors would like to recognize and acknowledge the very prominent cultural
role and reverence that the summit of Maunakea has always had within the indigenous
Hawaiian community. We are fortunate to have the opportunity to perform observations
from this mountain.
article_number: '8'
article_processing_charge: No
article_type: original
author:
- first_name: Behnam
full_name: Darvish, Behnam
last_name: Darvish
- first_name: Nick Z.
full_name: Scoville, Nick Z.
last_name: Scoville
- first_name: Christopher
full_name: Martin, Christopher
last_name: Martin
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Bahram
full_name: Mobasher, Bahram
last_name: Mobasher
- first_name: Alessandro
full_name: Rettura, Alessandro
last_name: Rettura
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Peter
full_name: Capak, Peter
last_name: Capak
- first_name: Nima
full_name: Chartab, Nima
last_name: Chartab
- first_name: Shoubaneh
full_name: Hemmati, Shoubaneh
last_name: Hemmati
- first_name: Daniel
full_name: Masters, Daniel
last_name: Masters
- first_name: Hooshang
full_name: Nayyeri, Hooshang
last_name: Nayyeri
- first_name: Donal
full_name: O’Sullivan, Donal
last_name: O’Sullivan
- first_name: Ana
full_name: Paulino-Afonso, Ana
last_name: Paulino-Afonso
- first_name: Zahra
full_name: Sattari, Zahra
last_name: Sattari
- first_name: Abtin
full_name: Shahidi, Abtin
last_name: Shahidi
- first_name: Mara
full_name: Salvato, Mara
last_name: Salvato
- first_name: Brian C.
full_name: Lemaux, Brian C.
last_name: Lemaux
- first_name: Olivier Le
full_name: Fèvre, Olivier Le
last_name: Fèvre
- first_name: Olga
full_name: Cucciati, Olga
last_name: Cucciati
citation:
ama: Darvish B, Scoville NZ, Martin C, et al. Spectroscopic confirmation of a coma
cluster progenitor at z ∼ 2.2. The Astrophysical Journal. 2020;892(1).
doi:10.3847/1538-4357/ab75c3
apa: Darvish, B., Scoville, N. Z., Martin, C., Sobral, D., Mobasher, B., Rettura,
A., … Cucciati, O. (2020). Spectroscopic confirmation of a coma cluster progenitor
at z ∼ 2.2. The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ab75c3
chicago: Darvish, Behnam, Nick Z. Scoville, Christopher Martin, David Sobral, Bahram
Mobasher, Alessandro Rettura, Jorryt J Matthee, et al. “Spectroscopic Confirmation
of a Coma Cluster Progenitor at z ∼ 2.2.” The Astrophysical Journal. IOP
Publishing, 2020. https://doi.org/10.3847/1538-4357/ab75c3.
ieee: B. Darvish et al., “Spectroscopic confirmation of a coma cluster progenitor
at z ∼ 2.2,” The Astrophysical Journal, vol. 892, no. 1. IOP Publishing,
2020.
ista: Darvish B, Scoville NZ, Martin C, Sobral D, Mobasher B, Rettura A, Matthee
JJ, Capak P, Chartab N, Hemmati S, Masters D, Nayyeri H, O’Sullivan D, Paulino-Afonso
A, Sattari Z, Shahidi A, Salvato M, Lemaux BC, Fèvre OL, Cucciati O. 2020. Spectroscopic
confirmation of a coma cluster progenitor at z ∼ 2.2. The Astrophysical Journal.
892(1), 8.
mla: Darvish, Behnam, et al. “Spectroscopic Confirmation of a Coma Cluster Progenitor
at z ∼ 2.2.” The Astrophysical Journal, vol. 892, no. 1, 8, IOP Publishing,
2020, doi:10.3847/1538-4357/ab75c3.
short: B. Darvish, N.Z. Scoville, C. Martin, D. Sobral, B. Mobasher, A. Rettura,
J.J. Matthee, P. Capak, N. Chartab, S. Hemmati, D. Masters, H. Nayyeri, D. O’Sullivan,
A. Paulino-Afonso, Z. Sattari, A. Shahidi, M. Salvato, B.C. Lemaux, O.L. Fèvre,
O. Cucciati, The Astrophysical Journal 892 (2020).
date_created: 2022-07-06T13:10:51Z
date_published: 2020-03-19T00:00:00Z
date_updated: 2022-07-19T09:31:35Z
day: '19'
doi: 10.3847/1538-4357/ab75c3
extern: '1'
external_id:
arxiv:
- '2002.06207'
intvolume: ' 892'
issue: '1'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2002.06207
month: '03'
oa: 1
oa_version: Preprint
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spectroscopic confirmation of a coma cluster progenitor at z ∼ 2.2
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 892
year: '2020'
...
---
_id: '11528'
abstract:
- lang: eng
text: Ly α emission lines are typically found to be redshifted with respect to the
systemic redshifts of galaxies, likely due to resonant scattering of Ly α photons.
Here, we measure the average velocity offset for a sample of 96 z ≈ 3.3 Ly α emitters
(LAEs) with a median Ly α flux (luminosity) of ≈10−17 erg cm−2 s−1 (≈1042 erg
s−1) and a median star formation rate (SFR) of ≈1.3 M⊙ yr−1 (not corrected for
possible dust extinction), detected by the Multi-Unit Spectroscopic Explorer as
part of our MUSEQuBES circumgalactic medium (CGM) survey. By postulating that
the stacked CGM absorption profiles of these LAEs, probed by eight background
quasars, must be centred on the systemic redshift, we measure an average velocity
offset, Voffset = 171\pm 8 km s−1, between the Ly α emission peak and the systemic
redshift. The observed Voffset is lower by factors of ≈1.4 and ≈2.6 compared to
the velocity offsets measured for narrow-band-selected LAEs and Lyman break galaxies,
respectively, which probe galaxies with higher masses and SFRs. Consistent with
earlier studies based on direct measurements for individual objects, we find that
the Voffset is correlated with the full width at half-maximum of the red peak
of the Ly α line, and anticorrelated with the rest-frame equivalent width. Moreover,
we find that Voffset is correlated with SFR with a sub-linear scaling relation,
Voffset∝SFR0.16±0.03. Adopting the mass scaling for main-sequence galaxies, such
a relation suggests that Voffset scales with the circular velocity of the dark
matter haloes hosting the LAEs.
acknowledgement: 'We thank the anonymous referee for useful suggestions. This study
is based on observations collected at the European Organisation for Astronomical
Research in the Southern Hemisphere under ESO programme(s): 094.A-0131(B), 095.A
0200(A), 096.A0222(A), 097.A-0089(A), and 099.A-0159(A). SM acknowledges support
from the Alexander von Humboldt Foundation, Germany. SM thanks Christian Herenz
for useful discussion. SC gratefully acknowledges support from Swiss National Science
Foundation grant PP00P2 163824. JB acknowledges support by FCT/MCTES through national
funds by grant UID/FIS/04434/2019 and through Investigador FCT Contract No. IF/01654/2014/CP1215/CT0003.
NB and JZ acknowledge support from ANR grant ANR-17-CE31- 0017 (3DGasFlows). AC
and JR acknowledge support from the ERC starting grant 336736-CALENDS. MA acknowledges
support from European Union’s H2020 Marie Skłodowska-Curie Actions grant 721463
to the SUNDIAL ITN, and from the Spanish Ministry of Economy and Competitiveness
(MINECO) under grant number AYA2016-76219-P. MA also acknowledges support from the
Fundacion BBVA under its 2017 programme of assistance to ´scientific research groups,
for the project ‘Using machine-learning techniques to drag galaxies from the noise
in deep imaging’. FL and AV acknowledge support from the ERC starting grant ERC757258-TRIPLE.'
article_processing_charge: No
article_type: original
author:
- first_name: Sowgat
full_name: Muzahid, Sowgat
last_name: Muzahid
- first_name: Joop
full_name: Schaye, Joop
last_name: Schaye
- first_name: Raffaella Anna
full_name: Marino, Raffaella Anna
last_name: Marino
- first_name: Sebastiano
full_name: Cantalupo, Sebastiano
last_name: Cantalupo
- first_name: Jarle
full_name: Brinchmann, Jarle
last_name: Brinchmann
- first_name: Thierry
full_name: Contini, Thierry
last_name: Contini
- first_name: Martin
full_name: Wendt, Martin
last_name: Wendt
- first_name: Lutz
full_name: Wisotzki, Lutz
last_name: Wisotzki
- first_name: Johannes
full_name: Zabl, Johannes
last_name: Zabl
- first_name: Nicolas
full_name: Bouché, Nicolas
last_name: Bouché
- first_name: Mohammad
full_name: Akhlaghi, Mohammad
last_name: Akhlaghi
- first_name: Hsiao-Wen
full_name: Chen, Hsiao-Wen
last_name: Chen
- first_name: Adélaîde
full_name: Claeyssens, Adélaîde
last_name: Claeyssens
- first_name: Sean
full_name: Johnson, Sean
last_name: Johnson
- first_name: Floriane
full_name: Leclercq, Floriane
last_name: Leclercq
- first_name: Michael
full_name: Maseda, Michael
last_name: Maseda
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Johan
full_name: Richard, Johan
last_name: Richard
- first_name: Tanya
full_name: Urrutia, Tanya
last_name: Urrutia
- first_name: Anne
full_name: Verhamme, Anne
last_name: Verhamme
citation:
ama: 'Muzahid S, Schaye J, Marino RA, et al. MUSEQuBES: Calibrating the redshifts
of Lyα emitters using stacked circumgalactic medium absorption profiles. Monthly
Notices of the Royal Astronomical Society. 2020;496(2):1013-1022. doi:10.1093/mnras/staa1347'
apa: 'Muzahid, S., Schaye, J., Marino, R. A., Cantalupo, S., Brinchmann, J., Contini,
T., … Verhamme, A. (2020). MUSEQuBES: Calibrating the redshifts of Lyα emitters
using stacked circumgalactic medium absorption profiles. Monthly Notices of
the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staa1347'
chicago: 'Muzahid, Sowgat, Joop Schaye, Raffaella Anna Marino, Sebastiano Cantalupo,
Jarle Brinchmann, Thierry Contini, Martin Wendt, et al. “MUSEQuBES: Calibrating
the Redshifts of Lyα Emitters Using Stacked Circumgalactic Medium Absorption Profiles.”
Monthly Notices of the Royal Astronomical Society. Oxford University Press,
2020. https://doi.org/10.1093/mnras/staa1347.'
ieee: 'S. Muzahid et al., “MUSEQuBES: Calibrating the redshifts of Lyα emitters
using stacked circumgalactic medium absorption profiles,” Monthly Notices of
the Royal Astronomical Society, vol. 496, no. 2. Oxford University Press,
pp. 1013–1022, 2020.'
ista: 'Muzahid S, Schaye J, Marino RA, Cantalupo S, Brinchmann J, Contini T, Wendt
M, Wisotzki L, Zabl J, Bouché N, Akhlaghi M, Chen H-W, Claeyssens A, Johnson S,
Leclercq F, Maseda M, Matthee JJ, Richard J, Urrutia T, Verhamme A. 2020. MUSEQuBES:
Calibrating the redshifts of Lyα emitters using stacked circumgalactic medium
absorption profiles. Monthly Notices of the Royal Astronomical Society. 496(2),
1013–1022.'
mla: 'Muzahid, Sowgat, et al. “MUSEQuBES: Calibrating the Redshifts of Lyα Emitters
Using Stacked Circumgalactic Medium Absorption Profiles.” Monthly Notices of
the Royal Astronomical Society, vol. 496, no. 2, Oxford University Press,
2020, pp. 1013–22, doi:10.1093/mnras/staa1347.'
short: S. Muzahid, J. Schaye, R.A. Marino, S. Cantalupo, J. Brinchmann, T. Contini,
M. Wendt, L. Wisotzki, J. Zabl, N. Bouché, M. Akhlaghi, H.-W. Chen, A. Claeyssens,
S. Johnson, F. Leclercq, M. Maseda, J.J. Matthee, J. Richard, T. Urrutia, A. Verhamme,
Monthly Notices of the Royal Astronomical Society 496 (2020) 1013–1022.
date_created: 2022-07-07T10:20:11Z
date_published: 2020-08-01T00:00:00Z
date_updated: 2022-08-18T11:00:24Z
day: '01'
doi: 10.1093/mnras/staa1347
extern: '1'
external_id:
arxiv:
- '1910.03593'
intvolume: ' 496'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: haloes'
- 'galaxies: high-redshift'
- 'quasars: absorption lines'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1910.03593
month: '08'
oa: 1
oa_version: Preprint
page: 1013-1022
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1093/mnras/staa2668
scopus_import: '1'
status: public
title: 'MUSEQuBES: Calibrating the redshifts of Lyα emitters using stacked circumgalactic
medium absorption profiles'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 496
year: '2020'
...
---
_id: '11529'
abstract:
- lang: eng
text: CR7 is among the most luminous Ly α emitters (LAEs) known at z = 6.6 and consists
of at least three UV components that are surrounded by Ly α emission. Previous
studies have suggested that it may host an extreme ionizing source. Here, we present
deep integral field spectroscopy of CR7 with VLT/Multi Unit Spectroscopic Explorer
(MUSE). We measure extended emission with a similar halo scale length as typical
LAEs at z ≈ 5. CR7’s Ly α halo is clearly elongated along the direction connecting
the multiple components, likely tracing the underlying gas distribution. The Ly α
emission originates almost exclusively from the brightest UV component, but we
also identify a faint kinematically distinct Ly α emitting region nearby a fainter
component. Combined with new near-infrared data, the MUSE data show that the rest-frame
Ly α equivalent width (EW) is ≈100 Å. This is a factor 4 higher than the EW measured
in low-redshift analogues with carefully matched Ly α profiles (and thus arguably
H I column density), but this EW can plausibly be explained by star formation.
Alternative scenarios requiring active galactic nucleus (AGN) powering are also
disfavoured by the narrower and steeper Ly α spectrum and much smaller IR to UV
ratio compared to obscured AGN in other Ly α blobs. CR7’s Ly α emission, while
extremely luminous, resembles the emission in more common LAEs at lower redshifts
very well and is likely powered by a young metal-poor starburst.
article_processing_charge: No
article_type: original
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Gabriele
full_name: Pezzulli, Gabriele
last_name: Pezzulli
- first_name: Ruari
full_name: Mackenzie, Ruari
last_name: Mackenzie
- first_name: Sebastiano
full_name: Cantalupo, Sebastiano
last_name: Cantalupo
- first_name: Haruka
full_name: Kusakabe, Haruka
last_name: Kusakabe
- first_name: Floriane
full_name: Leclercq, Floriane
last_name: Leclercq
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Johan
full_name: Richard, Johan
last_name: Richard
- first_name: Lutz
full_name: Wisotzki, Lutz
last_name: Wisotzki
- first_name: Simon
full_name: Lilly, Simon
last_name: Lilly
- first_name: Leindert
full_name: Boogaard, Leindert
last_name: Boogaard
- first_name: Raffaella
full_name: Marino, Raffaella
last_name: Marino
- first_name: Michael
full_name: Maseda, Michael
last_name: Maseda
- first_name: Themiya
full_name: Nanayakkara, Themiya
last_name: Nanayakkara
citation:
ama: 'Matthee JJ, Pezzulli G, Mackenzie R, et al. The nature of CR7 revealed with
MUSE: A young starburst powering extended Ly α emission at z = 6.6. Monthly
Notices of the Royal Astronomical Society. 2020;498(2):3043-3059. doi:10.1093/mnras/staa2550'
apa: 'Matthee, J. J., Pezzulli, G., Mackenzie, R., Cantalupo, S., Kusakabe, H.,
Leclercq, F., … Nanayakkara, T. (2020). The nature of CR7 revealed with MUSE:
A young starburst powering extended Ly α emission at z = 6.6. Monthly Notices
of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staa2550'
chicago: 'Matthee, Jorryt J, Gabriele Pezzulli, Ruari Mackenzie, Sebastiano Cantalupo,
Haruka Kusakabe, Floriane Leclercq, David Sobral, et al. “The Nature of CR7 Revealed
with MUSE: A Young Starburst Powering Extended Ly α Emission at z = 6.6.” Monthly
Notices of the Royal Astronomical Society. Oxford University Press, 2020.
https://doi.org/10.1093/mnras/staa2550.'
ieee: 'J. J. Matthee et al., “The nature of CR7 revealed with MUSE: A young
starburst powering extended Ly α emission at z = 6.6,” Monthly Notices of the
Royal Astronomical Society, vol. 498, no. 2. Oxford University Press, pp.
3043–3059, 2020.'
ista: 'Matthee JJ, Pezzulli G, Mackenzie R, Cantalupo S, Kusakabe H, Leclercq F,
Sobral D, Richard J, Wisotzki L, Lilly S, Boogaard L, Marino R, Maseda M, Nanayakkara
T. 2020. The nature of CR7 revealed with MUSE: A young starburst powering extended
Ly α emission at z = 6.6. Monthly Notices of the Royal Astronomical Society. 498(2),
3043–3059.'
mla: 'Matthee, Jorryt J., et al. “The Nature of CR7 Revealed with MUSE: A Young
Starburst Powering Extended Ly α Emission at z = 6.6.” Monthly Notices of the
Royal Astronomical Society, vol. 498, no. 2, Oxford University Press, 2020,
pp. 3043–59, doi:10.1093/mnras/staa2550.'
short: J.J. Matthee, G. Pezzulli, R. Mackenzie, S. Cantalupo, H. Kusakabe, F. Leclercq,
D. Sobral, J. Richard, L. Wisotzki, S. Lilly, L. Boogaard, R. Marino, M. Maseda,
T. Nanayakkara, Monthly Notices of the Royal Astronomical Society 498 (2020) 3043–3059.
date_created: 2022-07-07T10:36:01Z
date_published: 2020-10-01T00:00:00Z
date_updated: 2022-08-18T11:04:05Z
day: '01'
doi: 10.1093/mnras/staa2550
extern: '1'
external_id:
arxiv:
- '2008.01731'
intvolume: ' 498'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: evolution'
- 'galaxies: high-redshift'
- dark ages
- reionization
- first stars
- 'cosmology: observations'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2008.01731
month: '10'
oa: 1
oa_version: Preprint
page: 3043-3059
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The nature of CR7 revealed with MUSE: A young starburst powering extended
Ly α emission at z = 6.6'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 498
year: '2020'
...
---
_id: '11533'
abstract:
- lang: eng
text: We explore deep rest-frame UV to FIR data in the COSMOS field to measure the
individual spectral energy distributions (SED) of the ∼4000 SC4K (Sobral et al.)
Lyman α (Ly α) emitters (LAEs) at z ∼ 2–6. We find typical stellar masses of 109.3
± 0.6 M⊙ and star formation rates (SFR) of SFRSED=4.4+10.5−2.4 M⊙ yr−1 and SFRLyα=5.9+6.3−2.6 M⊙ yr−1,
combined with very blue UV slopes of β=−2.1+0.5−0.4, but with significant variations
within the population. MUV and β are correlated in a similar way to UV-selected
sources, but LAEs are consistently bluer. This suggests that LAEs are the youngest
and/or most dust-poor subset of the UV-selected population. We also study the
Ly α rest-frame equivalent width (EW0) and find 45 ‘extreme’ LAEs with EW0 > 240 Å
(3σ), implying a low number density of (7 ± 1) × 10−7 Mpc−3. Overall, we measure
little to no evolution of the Ly α EW0 and scale length parameter (w0), which
are consistently high (EW0=140+280−70 Å, w0=129+11−11 Å) from z ∼ 6 to z ∼ 2 and
below. However, w0 is anticorrelated with MUV and stellar mass. Our results imply
that sources selected as LAEs have a high Ly α escape fraction (fesc,Ly α) irrespective
of cosmic time, but fesc,Ly α is still higher for UV-fainter and lower mass LAEs.
The least massive LAEs (<109.5 M⊙) are typically located above the star formation
‘main sequence’ (MS), but the offset from the MS decreases towards z ∼ 6 and towards
1010 M⊙. Our results imply a lack of evolution in the properties of LAEs across
time and reveals the increasing overlap in properties of LAEs and UV-continuum
selected galaxies as typical star-forming galaxies at high redshift effectively
become LAEs.
acknowledgement: We thank the anonymous referee for the valuable feedback that significantly
improved the quality and clarity of this paper. SS and JC acknowledge studentships
from Lancaster University. APA acknowledges support from Fundação para a Ciência
e a Tecnologia through the project PTDC/FISAST/31546/2017. The authors would like
to thank Ali Khostovan, Sara Perez Sanchez, Alex Bennett and Tom Rose for contributions
and discussions in the early stages of this work. Based on data products from observations
made with ESO Telescopes at the La Silla Paranal Observatory under ESO programme
ID 179.A-2005 and on data products produced by CALET and the Cambridge Astronomy
Survey Unit on behalf of the UltraVISTA consortium. Finally, the authors acknowledge
the unique value of the publicly available analysis software TOPCAT (Taylor 2005)
and publicly available programming language Python, including the numpy, pyfits,
matplotlib, scipy and astropy (Astropy Collaboration et al. 2013) packages. This
work is based on the public SC4K sample of LAEs (Sobral et al. 2018a) and we release
the full catalogue with all the photometry and properties derived in this paper,
in electronic format, along with the relevant tables.
article_processing_charge: No
article_type: original
author:
- first_name: S
full_name: Santos, S
last_name: Santos
- first_name: D
full_name: Sobral, D
last_name: Sobral
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: J
full_name: Calhau, J
last_name: Calhau
- first_name: E
full_name: da Cunha, E
last_name: da Cunha
- first_name: B
full_name: Ribeiro, B
last_name: Ribeiro
- first_name: A
full_name: Paulino-Afonso, A
last_name: Paulino-Afonso
- first_name: P
full_name: Arrabal Haro, P
last_name: Arrabal Haro
- first_name: J
full_name: Butterworth, J
last_name: Butterworth
citation:
ama: Santos S, Sobral D, Matthee JJ, et al. The evolution of rest-frame UV properties,
Ly α EWs, and the SFR–stellar mass relation at z ∼ 2–6 for SC4K LAEs. Monthly
Notices of the Royal Astronomical Society. 2020;493(1):141-160. doi:10.1093/mnras/staa093
apa: Santos, S., Sobral, D., Matthee, J. J., Calhau, J., da Cunha, E., Ribeiro,
B., … Butterworth, J. (2020). The evolution of rest-frame UV properties, Ly α
EWs, and the SFR–stellar mass relation at z ∼ 2–6 for SC4K LAEs. Monthly Notices
of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staa093
chicago: Santos, S, D Sobral, Jorryt J Matthee, J Calhau, E da Cunha, B Ribeiro,
A Paulino-Afonso, P Arrabal Haro, and J Butterworth. “The Evolution of Rest-Frame
UV Properties, Ly α EWs, and the SFR–Stellar Mass Relation at z ∼ 2–6 for SC4K
LAEs.” Monthly Notices of the Royal Astronomical Society. Oxford University
Press, 2020. https://doi.org/10.1093/mnras/staa093.
ieee: S. Santos et al., “The evolution of rest-frame UV properties, Ly α
EWs, and the SFR–stellar mass relation at z ∼ 2–6 for SC4K LAEs,” Monthly Notices
of the Royal Astronomical Society, vol. 493, no. 1. Oxford University Press,
pp. 141–160, 2020.
ista: Santos S, Sobral D, Matthee JJ, Calhau J, da Cunha E, Ribeiro B, Paulino-Afonso
A, Arrabal Haro P, Butterworth J. 2020. The evolution of rest-frame UV properties,
Ly α EWs, and the SFR–stellar mass relation at z ∼ 2–6 for SC4K LAEs. Monthly
Notices of the Royal Astronomical Society. 493(1), 141–160.
mla: Santos, S., et al. “The Evolution of Rest-Frame UV Properties, Ly α EWs, and
the SFR–Stellar Mass Relation at z ∼ 2–6 for SC4K LAEs.” Monthly Notices of
the Royal Astronomical Society, vol. 493, no. 1, Oxford University Press,
2020, pp. 141–60, doi:10.1093/mnras/staa093.
short: S. Santos, D. Sobral, J.J. Matthee, J. Calhau, E. da Cunha, B. Ribeiro, A.
Paulino-Afonso, P. Arrabal Haro, J. Butterworth, Monthly Notices of the Royal
Astronomical Society 493 (2020) 141–160.
date_created: 2022-07-07T12:05:23Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2022-08-18T11:27:43Z
day: '01'
doi: 10.1093/mnras/staa093
extern: '1'
external_id:
arxiv:
- '1910.02959'
intvolume: ' 493'
issue: '1'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: evolution'
- 'galaxies: formation'
- 'galaxies: high-redshift'
- 'galaxies: star formation'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1910.02959
month: '03'
oa: 1
oa_version: Preprint
page: 141-160
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: The evolution of rest-frame UV properties, Ly α EWs, and the SFR–stellar mass
relation at z ∼ 2–6 for SC4K LAEs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 493
year: '2020'
...
---
_id: '11534'
abstract:
- lang: eng
text: The observed properties of the Lyman-α (Ly α) emission line are a powerful
probe of neutral gas in and around galaxies. We present spatially resolved Ly α
spectroscopy with VLT/MUSE targeting VR7, a UV-luminous galaxy at z = 6.532 with
moderate Ly α equivalent width (EW0 ≈ 38 Å). These data are combined with deep
resolved [CII]158μm spectroscopy obtained with ALMA and UV imaging from HST and
we also detect UV continuum with MUSE. Ly α emission is clearly detected with
S/N ≈ 40 and FWHM of 374 km s−1. Ly α and [C II] are similarly extended beyond
the UV, with effective radius reff = 2.1 ± 0.2 kpc for a single exponential model
or reff,Lyα,halo=3.45+1.08−0.87 kpc when measured jointly with the UV continuum.
The Ly α profile is broader and redshifted with respect to the [C II] line (by
213 km s−1), but there are spatial variations that are qualitatively similar in
both lines and coincide with resolved UV components. This suggests that the emission
originates from two components with plausibly different H I column densities.
We place VR7 in the context of other galaxies at similar and lower redshift. The
Ly α halo scale length is similar at different redshifts and velocity shifts with
respect to the systemic are typically smaller. Overall, we find little indications
of a more neutral vicinity at higher redshift. This means that the local (∼10 kpc)
neutral gas conditions that determine the observed Ly α properties in VR7 resemble
the conditions in post-reionization galaxies.
acknowledgement: 'We thank the referee for their suggestions and constructive comments
that helped to improve the presentation of our results. Based on observations obtained
with the Very Large Telescope, program 99.A-0462. Based on observations made with
the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute,
which is operated by the Association of Universities for Research in Astronomy,
Inc., under NASA contract NAS 5-26555. These observations are associated with program
#14699. This paper makes use of the following ALMA data: ADS/JAO.ALMA#2017.1.01451.S.
ALMA is a partnership of ESO (representing its member states), NSF (USA), and NINS
(Japan), together with NRC (Canada) and NSC and ASIAA (Taiwan) and KASI (Republic
of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory
is operated by ESO, AUI/NRAO, and NAOJ. MG acknowledges support from NASA grant
NNX17AK58G. GP and SC gratefully acknowledge support from Swiss National Science
Foundation grant PP00P2 163824. BD acknowledges financial support from the National
Science Foundation, grant number 1716907. We have benefited greatly from the public
available programming language PYTHON, including the NUMPY, MATPLOTLIB, SCIPY (Jones
et al. 2001; Hunter 2007; van der Walt, Colbert & Varoquaux 2011) and ASTROPY (Astropy
Collaboration 2013) packages, the astronomical imaging tools SEXTRACTOR, SWARP,
and SCAMP (Bertin & Arnouts 1996; Bertin 2006, 2010) and the TOPCAT analysis tool
(Taylor 2013).'
article_processing_charge: No
article_type: original
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Max
full_name: Gronke, Max
last_name: Gronke
- first_name: Gabriele
full_name: Pezzulli, Gabriele
last_name: Pezzulli
- first_name: Sebastiano
full_name: Cantalupo, Sebastiano
last_name: Cantalupo
- first_name: Huub
full_name: Röttgering, Huub
last_name: Röttgering
- first_name: Behnam
full_name: Darvish, Behnam
last_name: Darvish
- first_name: Sérgio
full_name: Santos, Sérgio
last_name: Santos
citation:
ama: Matthee JJ, Sobral D, Gronke M, et al. Resolved Lyman-α properties of a luminous
Lyman-break galaxy in a large ionized bubble at z = 6.53 . Monthly Notices
of the Royal Astronomical Society. 2020;492(2):1778-1790. doi:10.1093/mnras/stz3554
apa: Matthee, J. J., Sobral, D., Gronke, M., Pezzulli, G., Cantalupo, S., Röttgering,
H., … Santos, S. (2020). Resolved Lyman-α properties of a luminous Lyman-break
galaxy in a large ionized bubble at z = 6.53 . Monthly Notices of the Royal
Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stz3554
chicago: Matthee, Jorryt J, David Sobral, Max Gronke, Gabriele Pezzulli, Sebastiano
Cantalupo, Huub Röttgering, Behnam Darvish, and Sérgio Santos. “Resolved Lyman-α
Properties of a Luminous Lyman-Break Galaxy in a Large Ionized Bubble at z = 6.53
.” Monthly Notices of the Royal Astronomical Society. Oxford University
Press, 2020. https://doi.org/10.1093/mnras/stz3554.
ieee: J. J. Matthee et al., “Resolved Lyman-α properties of a luminous Lyman-break
galaxy in a large ionized bubble at z = 6.53 ,” Monthly Notices of the Royal
Astronomical Society, vol. 492, no. 2. Oxford University Press, pp. 1778–1790,
2020.
ista: Matthee JJ, Sobral D, Gronke M, Pezzulli G, Cantalupo S, Röttgering H, Darvish
B, Santos S. 2020. Resolved Lyman-α properties of a luminous Lyman-break galaxy
in a large ionized bubble at z = 6.53 . Monthly Notices of the Royal Astronomical
Society. 492(2), 1778–1790.
mla: Matthee, Jorryt J., et al. “Resolved Lyman-α Properties of a Luminous Lyman-Break
Galaxy in a Large Ionized Bubble at z = 6.53 .” Monthly Notices of the Royal
Astronomical Society, vol. 492, no. 2, Oxford University Press, 2020, pp.
1778–90, doi:10.1093/mnras/stz3554.
short: J.J. Matthee, D. Sobral, M. Gronke, G. Pezzulli, S. Cantalupo, H. Röttgering,
B. Darvish, S. Santos, Monthly Notices of the Royal Astronomical Society 492 (2020)
1778–1790.
date_created: 2022-07-07T12:21:36Z
date_published: 2020-02-01T00:00:00Z
date_updated: 2022-08-18T11:29:53Z
day: '01'
doi: 10.1093/mnras/stz3554
extern: '1'
external_id:
arxiv:
- '1909.06376'
intvolume: ' 492'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: evolution'
- 'galaxies: high-redshift'
- dark ages
- reionization
- first stars
- 'cosmology: observations'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1909.06376
month: '02'
oa: 1
oa_version: Preprint
page: 1778-1790
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Resolved Lyman-α properties of a luminous Lyman-break galaxy in a large ionized
bubble at z = 6.53 '
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 492
year: '2020'
...
---
_id: '11531'
abstract:
- lang: eng
text: While low-luminosity galaxies dominate number counts at all redshifts, their
contribution to cosmic reionization is poorly understood due to a lack of knowledge
of their physical properties. We isolate a sample of 35 z ≈ 4–5 continuum-faint
Lyman-α emitters from deep VLT/MUSE spectroscopy and directly measure their H α
emission using stacked Spitzer/IRAC Ch. 1 photometry. Based on Hubble Space Telescope
imaging, we determine that the average UV continuum magnitude is fainter than
−16 (≈ 0.01 L⋆), implying a median Lyman-α equivalent width of 259 Å. By combining
the H α measurement with the UV magnitude, we determine the ionizing photon production
efficiency, ξion, a first for such faint galaxies. The measurement of log10 (ξion
[Hz erg−1]) = 26.28 (+0.28−0.40) is in excess of literature measurements of
both continuum- and emission line-selected samples, implying a more efficient
production of ionizing photons in these lower luminosity, Lyman-α-selected systems.
We conclude that this elevated efficiency can be explained by stellar populations
with metallicities between 4 × 10−4 and 0.008, with light-weighted ages less than
3 Myr.
acknowledgement: 'We would like to thank the anonymous referee for a thoughtful report
and suggestions that have improved this manuscript. We are also grateful to everyone
involved in the Spitzer Space Telescope mission and everyone at the Spitzer Science
Center: we are truly fortunate to have been able to use data from this facility.
J. B. acknowledges support by FCT/MCTES through national funds by this grant UID/FIS/04434/2019
and through the Investigador FCT contract no. IF/01654/2014/CP1215/CT0003. S. C.
gratefully acknowledges support from Swiss National Science Foundation grant PP00P2
163824. We would also like to thank Mauro Stefanon for his assistance with de-blending
the IRAC photometry, Pieter van Dokkum for a number of useful suggestions, and Daniel
Schaerer for information regarding the stellar population models. This study is
based on observations made with ESO telescopes at the La Silla Paranal Observatory
under programs IDs 094.A-2089(B), 095.A0010(A), 096.A-0045(A), and 096.A-0045(B).'
article_processing_charge: No
article_type: original
author:
- first_name: Michael V
full_name: Maseda, Michael V
last_name: Maseda
- first_name: Roland
full_name: Bacon, Roland
last_name: Bacon
- first_name: Daniel
full_name: Lam, Daniel
last_name: Lam
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Jarle
full_name: Brinchmann, Jarle
last_name: Brinchmann
- first_name: Joop
full_name: Schaye, Joop
last_name: Schaye
- first_name: Ivo
full_name: Labbe, Ivo
last_name: Labbe
- first_name: Kasper B
full_name: Schmidt, Kasper B
last_name: Schmidt
- first_name: Leindert
full_name: Boogaard, Leindert
last_name: Boogaard
- first_name: Rychard
full_name: Bouwens, Rychard
last_name: Bouwens
- first_name: Sebastiano
full_name: Cantalupo, Sebastiano
last_name: Cantalupo
- first_name: Marijn
full_name: Franx, Marijn
last_name: Franx
- first_name: Takuya
full_name: Hashimoto, Takuya
last_name: Hashimoto
- first_name: Hanae
full_name: Inami, Hanae
last_name: Inami
- first_name: Haruka
full_name: Kusakabe, Haruka
last_name: Kusakabe
- first_name: Guillaume
full_name: Mahler, Guillaume
last_name: Mahler
- first_name: Themiya
full_name: Nanayakkara, Themiya
last_name: Nanayakkara
- first_name: Johan
full_name: Richard, Johan
last_name: Richard
- first_name: Lutz
full_name: Wisotzki, Lutz
last_name: Wisotzki
citation:
ama: Maseda MV, Bacon R, Lam D, et al. Elevated ionizing photon production efficiency
in faint high-equivalent-width Lyman-α emitters. Monthly Notices of the Royal
Astronomical Society. 2020;493(4):5120-5130. doi:10.1093/mnras/staa622
apa: Maseda, M. V., Bacon, R., Lam, D., Matthee, J. J., Brinchmann, J., Schaye,
J., … Wisotzki, L. (2020). Elevated ionizing photon production efficiency in faint
high-equivalent-width Lyman-α emitters. Monthly Notices of the Royal Astronomical
Society. Oxford University Press. https://doi.org/10.1093/mnras/staa622
chicago: Maseda, Michael V, Roland Bacon, Daniel Lam, Jorryt J Matthee, Jarle Brinchmann,
Joop Schaye, Ivo Labbe, et al. “Elevated Ionizing Photon Production Efficiency
in Faint High-Equivalent-Width Lyman-α Emitters.” Monthly Notices of the Royal
Astronomical Society. Oxford University Press, 2020. https://doi.org/10.1093/mnras/staa622.
ieee: M. V. Maseda et al., “Elevated ionizing photon production efficiency
in faint high-equivalent-width Lyman-α emitters,” Monthly Notices of the Royal
Astronomical Society, vol. 493, no. 4. Oxford University Press, pp. 5120–5130,
2020.
ista: Maseda MV, Bacon R, Lam D, Matthee JJ, Brinchmann J, Schaye J, Labbe I, Schmidt
KB, Boogaard L, Bouwens R, Cantalupo S, Franx M, Hashimoto T, Inami H, Kusakabe
H, Mahler G, Nanayakkara T, Richard J, Wisotzki L. 2020. Elevated ionizing photon
production efficiency in faint high-equivalent-width Lyman-α emitters. Monthly
Notices of the Royal Astronomical Society. 493(4), 5120–5130.
mla: Maseda, Michael V., et al. “Elevated Ionizing Photon Production Efficiency
in Faint High-Equivalent-Width Lyman-α Emitters.” Monthly Notices of the Royal
Astronomical Society, vol. 493, no. 4, Oxford University Press, 2020, pp.
5120–30, doi:10.1093/mnras/staa622.
short: M.V. Maseda, R. Bacon, D. Lam, J.J. Matthee, J. Brinchmann, J. Schaye, I.
Labbe, K.B. Schmidt, L. Boogaard, R. Bouwens, S. Cantalupo, M. Franx, T. Hashimoto,
H. Inami, H. Kusakabe, G. Mahler, T. Nanayakkara, J. Richard, L. Wisotzki, Monthly
Notices of the Royal Astronomical Society 493 (2020) 5120–5130.
date_created: 2022-07-07T10:46:41Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2022-08-18T11:23:27Z
day: '01'
doi: 10.1093/mnras/staa622
extern: '1'
external_id:
arxiv:
- '2002.11117'
intvolume: ' 493'
issue: '4'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'Galaxies: evolution'
- 'Galaxies: high-redshift'
- 'Galaxies: ISM'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1093/mnras/staa622
month: '04'
oa: 1
oa_version: Published Version
page: 5120-5130
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Elevated ionizing photon production efficiency in faint high-equivalent-width
Lyman-α emitters
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 493
year: '2020'
...
---
_id: '11530'
abstract:
- lang: eng
text: A prediction of the classic active galactic nucleus (AGN) unification model
is the presence of ionization cones with different orientations depending on the
AGN type. Confirmations of this model exist for present times, but it is less
clear in the early Universe. Here, we use the morphology of giant Ly α nebulae
around AGNs at redshift z ∼ 3 to probe AGN emission and therefore the validity
of the AGN unification model at this redshift. We compare the spatial morphology
of 19 nebulae previously found around type I AGNs with a new sample of four Ly α
nebulae detected around type II AGNs. Using two independent techniques, we find
that nebulae around type II AGNs are more asymmetric than around type I, at least
at radial distances r > 30 physical kpc (pkpc) from the ionizing source. We conclude
that the type I and type II AGNs in our sample show evidence of different surrounding
ionizing geometries. This suggests that the classical AGN unification model is
also valid for high-redshift sources. Finally, we discuss how the lack of asymmetry
in the inner parts (r ≲ 30 pkpc) and the associated high values of the He II to
Ly α ratios in these regions could indicate additional sources of (hard) ionizing
radiation originating within or in proximity of the AGN host galaxies. This work
demonstrates that the morphologies of giant Ly α nebulae can be used to understand
and study the geometry of high-redshift AGNs on circumnuclear scales and it lays
the foundation for future studies using much larger statistical samples.
acknowledgement: SC and GP gratefully acknowledge support from Swiss National Science
Foundation grant PP00P2 163824. MK acknowledges support by DLR500R1904.
article_processing_charge: No
article_type: original
author:
- first_name: J S
full_name: den Brok, J S
last_name: den Brok
- first_name: S
full_name: Cantalupo, S
last_name: Cantalupo
- first_name: R
full_name: Mackenzie, R
last_name: Mackenzie
- first_name: R A
full_name: Marino, R A
last_name: Marino
- first_name: G
full_name: Pezzulli, G
last_name: Pezzulli
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: S D
full_name: Johnson, S D
last_name: Johnson
- first_name: M
full_name: Krumpe, M
last_name: Krumpe
- first_name: T
full_name: Urrutia, T
last_name: Urrutia
- first_name: W
full_name: Kollatschny, W
last_name: Kollatschny
citation:
ama: den Brok JS, Cantalupo S, Mackenzie R, et al. Probing the AGN unification model
at redshift z ∼ 3 with MUSE observations of giant Lyα nebulae. Monthly Notices
of the Royal Astronomical Society. 2020;495(2):1874-1887. doi:10.1093/mnras/staa1269
apa: den Brok, J. S., Cantalupo, S., Mackenzie, R., Marino, R. A., Pezzulli, G.,
Matthee, J. J., … Kollatschny, W. (2020). Probing the AGN unification model at
redshift z ∼ 3 with MUSE observations of giant Lyα nebulae. Monthly Notices
of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staa1269
chicago: den Brok, J S, S Cantalupo, R Mackenzie, R A Marino, G Pezzulli, Jorryt
J Matthee, S D Johnson, M Krumpe, T Urrutia, and W Kollatschny. “Probing the AGN
Unification Model at Redshift z ∼ 3 with MUSE Observations of Giant Lyα Nebulae.”
Monthly Notices of the Royal Astronomical Society. Oxford University Press,
2020. https://doi.org/10.1093/mnras/staa1269.
ieee: J. S. den Brok et al., “Probing the AGN unification model at redshift
z ∼ 3 with MUSE observations of giant Lyα nebulae,” Monthly Notices of the
Royal Astronomical Society, vol. 495, no. 2. Oxford University Press, pp.
1874–1887, 2020.
ista: den Brok JS, Cantalupo S, Mackenzie R, Marino RA, Pezzulli G, Matthee JJ,
Johnson SD, Krumpe M, Urrutia T, Kollatschny W. 2020. Probing the AGN unification
model at redshift z ∼ 3 with MUSE observations of giant Lyα nebulae. Monthly Notices
of the Royal Astronomical Society. 495(2), 1874–1887.
mla: den Brok, J. S., et al. “Probing the AGN Unification Model at Redshift z ∼
3 with MUSE Observations of Giant Lyα Nebulae.” Monthly Notices of the Royal
Astronomical Society, vol. 495, no. 2, Oxford University Press, 2020, pp.
1874–87, doi:10.1093/mnras/staa1269.
short: J.S. den Brok, S. Cantalupo, R. Mackenzie, R.A. Marino, G. Pezzulli, J.J.
Matthee, S.D. Johnson, M. Krumpe, T. Urrutia, W. Kollatschny, Monthly Notices
of the Royal Astronomical Society 495 (2020) 1874–1887.
date_created: 2022-07-07T10:40:17Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2022-08-18T11:17:47Z
day: '01'
doi: 10.1093/mnras/staa1269
extern: '1'
external_id:
arxiv:
- '2005.01732'
intvolume: ' 495'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: active'
- 'galaxies: high-redshift'
- intergalactic medium
- 'quasars: emission lines'
- 'quasars: general'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2005.01732
month: '06'
oa: 1
oa_version: Preprint
page: 1874-1887
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Probing the AGN unification model at redshift z ∼ 3 with MUSE observations
of giant Lyα nebulae
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 495
year: '2020'
...
---
_id: '11539'
abstract:
- lang: eng
text: 'Despite recent progress in understanding Ly α emitters (LAEs), relatively
little is known regarding their typical black hole activity across cosmic time.
Here, we study the X-ray and radio properties of ∼4000 LAEs at 2.2 < z < 6 from
the SC4K survey in the COSMOS field. We detect 254 (6.8per cent±0.4per cent)
LAEs individually in the X-rays (S/N > 3) with an average luminosity of 1044.31±0.01ergs−1
and average black hole accretion rate (BHAR) of 0.72±0.01 M⊙ yr−1, consistent
with moderate to high accreting active galactic neuclei (AGNs). We detect 120
sources in deep radio data (radio AGN fraction of 3.2per cent±0.3per cent). The
global AGN fraction (8.6per cent±0.4per cent) rises with Ly α luminosity and
declines with increasing redshift. For X-ray-detected LAEs, Ly α luminosities
correlate with the BHARs, suggesting that Ly α luminosity becomes a BHAR indicator.
Most LAEs (93.1per cent±0.6per cent) at 2 < z < 6 have no detectable X-ray emission
(BHARs < 0.017 M⊙ yr−1). The median star formation rate (SFR) of star-forming
LAEs from Ly α and radio luminosities is 7.6+6.6−2.8 M⊙ yr−1. The black hole to
galaxy growth ratio (BHAR/SFR) for LAEs is <0.0022, consistent with typical star-forming
galaxies and the local BHAR/SFR relation. We conclude that LAEs at 2 < z < 6 include
two different populations: an AGN population, where Ly α luminosity traces BHAR,
and another with low SFRs which remain undetected in even the deepest X-ray stacks
but is detected in the radio stacks.'
acknowledgement: JM acknowledges the support of a Huygens PhD fellowship from Leiden
University. We thank Camila Correa for help analysing snipshot merger trees. We
thank the anonymous referee for constructive comments. We also thank Jarle Brinchmann,
Rob Crain, Antonios Katsianis, Paola Popesso, and David Sobral for discussions and
suggestions. We also thank the participants of the Lorentz Center workshop ‘A Decade
of the Star-Forming Main Sequence’ held on 2017 September 4–8, for discussions and
ideas. We have benefited from the public available programming language PYTHON,
including the NUMPY, MATPLOTLIB, and SCIPY (Hunter 2007) packages and the TOPCAT
analysis tool (Taylor 2013).
article_processing_charge: No
article_type: original
author:
- first_name: João
full_name: Calhau, João
last_name: Calhau
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Sérgio
full_name: Santos, Sérgio
last_name: Santos
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Ana
full_name: Paulino-Afonso, Ana
last_name: Paulino-Afonso
- first_name: Andra
full_name: Stroe, Andra
last_name: Stroe
- first_name: Brooke
full_name: Simmons, Brooke
last_name: Simmons
- first_name: Cassandra
full_name: Barlow-Hall, Cassandra
last_name: Barlow-Hall
- first_name: Benjamin
full_name: Adams, Benjamin
last_name: Adams
citation:
ama: 'Calhau J, Sobral D, Santos S, et al. The X-ray and radio activity of typical
and luminous Ly α emitters from z ∼ 2 to z ∼ 6: Evidence for a diverse, evolving
population. Monthly Notices of the Royal Astronomical Society. 2020;493(3):3341-3362.
doi:10.1093/mnras/staa476'
apa: 'Calhau, J., Sobral, D., Santos, S., Matthee, J. J., Paulino-Afonso, A., Stroe,
A., … Adams, B. (2020). The X-ray and radio activity of typical and luminous Ly α
emitters from z ∼ 2 to z ∼ 6: Evidence for a diverse, evolving population. Monthly
Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staa476'
chicago: 'Calhau, João, David Sobral, Sérgio Santos, Jorryt J Matthee, Ana Paulino-Afonso,
Andra Stroe, Brooke Simmons, Cassandra Barlow-Hall, and Benjamin Adams. “The X-Ray
and Radio Activity of Typical and Luminous Ly α Emitters from z ∼ 2 to z ∼ 6:
Evidence for a Diverse, Evolving Population.” Monthly Notices of the Royal
Astronomical Society. Oxford University Press, 2020. https://doi.org/10.1093/mnras/staa476.'
ieee: 'J. Calhau et al., “The X-ray and radio activity of typical and luminous
Ly α emitters from z ∼ 2 to z ∼ 6: Evidence for a diverse, evolving population,”
Monthly Notices of the Royal Astronomical Society, vol. 493, no. 3. Oxford
University Press, pp. 3341–3362, 2020.'
ista: 'Calhau J, Sobral D, Santos S, Matthee JJ, Paulino-Afonso A, Stroe A, Simmons
B, Barlow-Hall C, Adams B. 2020. The X-ray and radio activity of typical and luminous
Ly α emitters from z ∼ 2 to z ∼ 6: Evidence for a diverse, evolving population.
Monthly Notices of the Royal Astronomical Society. 493(3), 3341–3362.'
mla: 'Calhau, João, et al. “The X-Ray and Radio Activity of Typical and Luminous
Ly α Emitters from z ∼ 2 to z ∼ 6: Evidence for a Diverse, Evolving Population.”
Monthly Notices of the Royal Astronomical Society, vol. 493, no. 3, Oxford
University Press, 2020, pp. 3341–62, doi:10.1093/mnras/staa476.'
short: J. Calhau, D. Sobral, S. Santos, J.J. Matthee, A. Paulino-Afonso, A. Stroe,
B. Simmons, C. Barlow-Hall, B. Adams, Monthly Notices of the Royal Astronomical
Society 493 (2020) 3341–3362.
date_created: 2022-07-08T07:34:10Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2022-08-18T11:25:31Z
day: '01'
doi: 10.1093/mnras/staa476
extern: '1'
external_id:
arxiv:
- '1909.11672'
intvolume: ' 493'
issue: '3'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: active'
- 'galaxies: evolution'
- 'galaxies: high-redshift'
- 'quasars: supermassive black holes'
- 'galaxies: star formation'
- 'cosmology: observations'
- 'X-rays: galaxies'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1909.11672
month: '04'
oa: 1
oa_version: Preprint
page: 3341-3362
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The X-ray and radio activity of typical and luminous Ly α emitters from z
∼ 2 to z ∼ 6: Evidence for a diverse, evolving population'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 493
year: '2020'
...
---
_id: '11586'
abstract:
- lang: eng
text: Distant luminous Lyman-α emitters are excellent targets for detailed observations
of galaxies in the epoch of reionisation. Spatially resolved observations of these
galaxies allow us to simultaneously probe the emission from young stars, partially
ionised gas in the interstellar medium and to constrain the properties of the
surrounding hydrogen in the circumgalactic medium. We review recent results from
(spectroscopic) follow-up studies of the rest-frame UV, Lyman-α and [CII] emission
in luminous galaxies observed ∼500 Myr after the Big Bang with ALMA, HST/WFC3
and VLT/X-SHOOTER. These galaxies likely reside in early ionised bubbles and are
complex systems, consisting of multiple well separated and resolved components
where traces of metals are already present.
article_processing_charge: No
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: David
full_name: Sobral, David
last_name: Sobral
citation:
ama: 'Matthee JJ, Sobral D. Unveiling the most luminous Lyman-α emitters in the
epoch of reionisation. In: Proceedings of the International Astronomical Union.
Vol 15. Cambridge University Press; 2020:21-25. doi:10.1017/s1743921319009451'
apa: Matthee, J. J., & Sobral, D. (2020). Unveiling the most luminous Lyman-α
emitters in the epoch of reionisation. In Proceedings of the International
Astronomical Union (Vol. 15, pp. 21–25). Cambridge University Press. https://doi.org/10.1017/s1743921319009451
chicago: Matthee, Jorryt J, and David Sobral. “Unveiling the Most Luminous Lyman-α
Emitters in the Epoch of Reionisation.” In Proceedings of the International
Astronomical Union, 15:21–25. Cambridge University Press, 2020. https://doi.org/10.1017/s1743921319009451.
ieee: J. J. Matthee and D. Sobral, “Unveiling the most luminous Lyman-α emitters
in the epoch of reionisation,” in Proceedings of the International Astronomical
Union, 2020, vol. 15, no. S352, pp. 21–25.
ista: Matthee JJ, Sobral D. 2020. Unveiling the most luminous Lyman-α emitters in
the epoch of reionisation. Proceedings of the International Astronomical Union.
vol. 15, 21–25.
mla: Matthee, Jorryt J., and David Sobral. “Unveiling the Most Luminous Lyman-α
Emitters in the Epoch of Reionisation.” Proceedings of the International Astronomical
Union, vol. 15, no. S352, Cambridge University Press, 2020, pp. 21–25, doi:10.1017/s1743921319009451.
short: J.J. Matthee, D. Sobral, in:, Proceedings of the International Astronomical
Union, Cambridge University Press, 2020, pp. 21–25.
date_created: 2022-07-14T14:08:41Z
date_published: 2020-06-04T00:00:00Z
date_updated: 2022-08-19T08:41:12Z
day: '04'
doi: 10.1017/s1743921319009451
extern: '1'
external_id:
arxiv:
- '1911.04774'
intvolume: ' 15'
issue: S352
keyword:
- Astronomy and Astrophysics
- Space and Planetary Science
- 'galaxies: formation'
- 'galaxies: evolution'
- 'galaxies: high-redshift'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1911.04774
month: '06'
oa: 1
oa_version: Preprint
page: 21-25
publication: Proceedings of the International Astronomical Union
publication_identifier:
eissn:
- 1743-9221
issn:
- 1743-9213
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unveiling the most luminous Lyman-α emitters in the epoch of reionisation
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2020'
...
---
_id: '11610'
abstract:
- lang: eng
text: Studies of Galactic structure and evolution have benefited enormously from
Gaia kinematic information, though additional, intrinsic stellar parameters like
age are required to best constrain Galactic models. Asteroseismology is the most
precise method of providing such information for field star populations en masse,
but existing samples for the most part have been limited to a few narrow fields
of view by the CoRoT and Kepler missions. In an effort to provide well-characterized
stellar parameters across a wide range in Galactic position, we present the second
data release of red giant asteroseismic parameters for the K2 Galactic Archaeology
Program (GAP). We provide ${\nu }_{\max }$ and ${\rm{\Delta }}\nu $ based on six
independent pipeline analyses; first-ascent red giant branch (RGB) and red clump
(RC) evolutionary state classifications from machine learning; and ready-to-use
radius and mass coefficients, κR and κM, which, when appropriately multiplied
by a solar-scaled effective temperature factor, yield physical stellar radii and
masses. In total, we report 4395 radius and mass coefficients, with typical uncertainties
of 3.3% (stat.) ± 1% (syst.) for κR and 7.7% (stat.) ± 2% (syst.) for κM among
RGB stars, and 5.0% (stat.) ± 1% (syst.) for κR and 10.5% (stat.) ± 2% (syst.)
for κM among RC stars. We verify that the sample is nearly complete—except for
a dearth of stars with ${\nu }_{\max }\lesssim 10\mbox{--}20\,\mu \mathrm{Hz}$—by
comparing to Galactic models and visual inspection. Our asteroseismic radii agree
with radii derived from Gaia Data Release 2 parallaxes to within 2.2% ± 0.3% for
RGB stars and 2.0% ± 0.6% for RC stars.
acknowledgement: "We thank the referee for comments that strengthened the manuscript.
J. C. Z. and M. H. P. acknowledge support from NASA grants 80NSSC18K0391 and NNX17AJ40G.
Y. E. and C. J. acknowledge the support of the UK Science and Technology Facilities
Council (STFC). S. M. would like to acknowledge support from the Spanish Ministry
with the Ramon y Cajal fellowship number RYC-2015-17697. R. A. G. acknowledges funding
received from the PLATO CNES grant. R. S. acknowledges funding via a Royal Society
University Research Fellowship. D.H. acknowledges support from the Alfred P. Sloan
Foundation and the National Aeronautics and Space Administration (80NSSC19K0108).
V.S.A. acknowledges support from the Independent Research Fund Denmark (Research
grant 7027-00096B), and the Carlsberg foundation (grant agreement CF19-0649). This
research was supported in part by the National Science Foundation under grant No.
NSF PHY-1748958.\r\n\r\nFunding for the Stellar Astrophysics Centre (SAC) is provided
by The Danish National Research Foundation (grant agreement No. DNRF106).\r\n\r\nThe
K2 Galactic Archaeology Program is supported by the National Aeronautics and Space
Administration under grant NNX16AJ17G issued through the K2 Guest Observer Program.\r\n\r\nThis
publication makes use of data products from the Two Micron All Sky Survey, which
is a joint project of the University of Massachusetts and the Infrared Processing
and Analysis Center/California Institute of Technology, funded by the National Aeronautics
and Space Administration and the National Science Foundation.\r\n\r\nThis work has
made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia),
processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium).
Funding for the DPAC has been provided by national institutions, in particular the
institutions participating in the Gaia Multilateral Agreement.\r\n\r\nFunding for
the Sloan Digital Sky Survey IV has been provided by the Alfred P. Sloan Foundation,
the U.S. Department of Energy Office of Science, and the Participating Institutions.
SDSS-IV acknowledges support and resources from the Center for High Performance
Computing at the University of Utah. The SDSS website is www.sdss.org.\r\n\r\nSDSS-IV
is managed by the Astrophysical Research Consortium for the Participating Institutions
of the SDSS Collaboration, including the Brazilian Participation Group, the Carnegie
Institution for Science, Carnegie Mellon University, the Chilean Participation Group,
the French Participation Group, the Harvard–Smithsonian Center for Astrophysics,
Instituto de Astrofísica de Canarias, The Johns Hopkins University, Kavli Institute
for the Physics and Mathematics of the Universe (IPMU)/University of Tokyo, the
Korean Participation Group, Lawrence Berkeley National Laboratory, Leibniz Institut
für Astrophysik Potsdam (AIP), Max-Planck-Institut für Astronomie (MPIA Heidelberg),
Max-Planck-Institut für Astrophysik (MPA Garching), Max-Planck-Institut für Extraterrestrische
Physik (MPE), National Astronomical Observatories of China, New Mexico State University,
New York University, University of Notre Dame, Observatário Nacional/MCTI, The Ohio
State University, Pennsylvania State University, Shanghai Astronomical Observatory,
United Kingdom Participation Group, Universidad Nacional Autónoma de México, University
of Arizona, University of Colorado Boulder, University of Oxford, University of
Portsmouth, University of Utah, University of Virginia, University of Washington,
University of Wisconsin, Vanderbilt University, and Yale University.\r\n\r\nSoftware:
asfgrid (Sharma & Stello 2016), emcee (Foreman-Mackey et al. 2013), NumPy (Walt
2011), pandas (McKinney 2010; Reback et al. 2020), Matplotlib (Hunter 2007), IPython
(Pérez & Granger 2007), SciPy (Virtanen et al. 2020)."
article_number: '23'
article_processing_charge: No
article_type: original
author:
- first_name: Joel C.
full_name: Zinn, Joel C.
last_name: Zinn
- first_name: Dennis
full_name: Stello, Dennis
last_name: Stello
- first_name: Yvonne
full_name: Elsworth, Yvonne
last_name: Elsworth
- first_name: Rafael A.
full_name: García, Rafael A.
last_name: García
- first_name: Thomas
full_name: Kallinger, Thomas
last_name: Kallinger
- first_name: Savita
full_name: Mathur, Savita
last_name: Mathur
- first_name: Benoît
full_name: Mosser, Benoît
last_name: Mosser
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
- first_name: Caitlin
full_name: Jones, Caitlin
last_name: Jones
- first_name: Marc
full_name: Hon, Marc
last_name: Hon
- first_name: Sanjib
full_name: Sharma, Sanjib
last_name: Sharma
- first_name: Ralph
full_name: Schönrich, Ralph
last_name: Schönrich
- first_name: Jack T.
full_name: Warfield, Jack T.
last_name: Warfield
- first_name: Rodrigo
full_name: Luger, Rodrigo
last_name: Luger
- first_name: Marc H.
full_name: Pinsonneault, Marc H.
last_name: Pinsonneault
- first_name: Jennifer A.
full_name: Johnson, Jennifer A.
last_name: Johnson
- first_name: Daniel
full_name: Huber, Daniel
last_name: Huber
- first_name: Victor Silva
full_name: Aguirre, Victor Silva
last_name: Aguirre
- first_name: William J.
full_name: Chaplin, William J.
last_name: Chaplin
- first_name: Guy R.
full_name: Davies, Guy R.
last_name: Davies
- first_name: Andrea
full_name: Miglio, Andrea
last_name: Miglio
citation:
ama: 'Zinn JC, Stello D, Elsworth Y, et al. The K2 galactic archaeology program
data release 2: Asteroseismic results from campaigns 4, 6, and 7. The Astrophysical
Journal Supplement Series. 2020;251(2). doi:10.3847/1538-4365/abbee3'
apa: 'Zinn, J. C., Stello, D., Elsworth, Y., García, R. A., Kallinger, T., Mathur,
S., … Miglio, A. (2020). The K2 galactic archaeology program data release 2: Asteroseismic
results from campaigns 4, 6, and 7. The Astrophysical Journal Supplement Series.
IOP Publishing. https://doi.org/10.3847/1538-4365/abbee3'
chicago: 'Zinn, Joel C., Dennis Stello, Yvonne Elsworth, Rafael A. García, Thomas
Kallinger, Savita Mathur, Benoît Mosser, et al. “The K2 Galactic Archaeology Program
Data Release 2: Asteroseismic Results from Campaigns 4, 6, and 7.” The Astrophysical
Journal Supplement Series. IOP Publishing, 2020. https://doi.org/10.3847/1538-4365/abbee3.'
ieee: 'J. C. Zinn et al., “The K2 galactic archaeology program data release
2: Asteroseismic results from campaigns 4, 6, and 7,” The Astrophysical Journal
Supplement Series, vol. 251, no. 2. IOP Publishing, 2020.'
ista: 'Zinn JC, Stello D, Elsworth Y, García RA, Kallinger T, Mathur S, Mosser B,
Bugnet LA, Jones C, Hon M, Sharma S, Schönrich R, Warfield JT, Luger R, Pinsonneault
MH, Johnson JA, Huber D, Aguirre VS, Chaplin WJ, Davies GR, Miglio A. 2020. The
K2 galactic archaeology program data release 2: Asteroseismic results from campaigns
4, 6, and 7. The Astrophysical Journal Supplement Series. 251(2), 23.'
mla: 'Zinn, Joel C., et al. “The K2 Galactic Archaeology Program Data Release 2:
Asteroseismic Results from Campaigns 4, 6, and 7.” The Astrophysical Journal
Supplement Series, vol. 251, no. 2, 23, IOP Publishing, 2020, doi:10.3847/1538-4365/abbee3.'
short: J.C. Zinn, D. Stello, Y. Elsworth, R.A. García, T. Kallinger, S. Mathur,
B. Mosser, L.A. Bugnet, C. Jones, M. Hon, S. Sharma, R. Schönrich, J.T. Warfield,
R. Luger, M.H. Pinsonneault, J.A. Johnson, D. Huber, V.S. Aguirre, W.J. Chaplin,
G.R. Davies, A. Miglio, The Astrophysical Journal Supplement Series 251 (2020).
date_created: 2022-07-18T13:27:26Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2022-08-22T07:04:45Z
day: '01'
doi: 10.3847/1538-4365/abbee3
extern: '1'
external_id:
arxiv:
- '2012.04051'
intvolume: ' 251'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2012.04051
month: '12'
oa: 1
oa_version: Preprint
publication: The Astrophysical Journal Supplement Series
publication_identifier:
eissn:
- 1538-4365
issn:
- 0067-0049
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The K2 galactic archaeology program data release 2: Asteroseismic results
from campaigns 4, 6, and 7'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 251
year: '2020'
...
---
_id: '11611'
abstract:
- lang: eng
text: Over the course of its history, the Milky Way has ingested multiple smaller
satellite galaxies1. Although these accreted stellar populations can be forensically
identified as kinematically distinct structures within the Galaxy, it is difficult
in general to date precisely the age at which any one merger occurred. Recent
results have revealed a population of stars that were accreted via the collision
of a dwarf galaxy, called Gaia–Enceladus1, leading to substantial pollution of
the chemical and dynamical properties of the Milky Way. Here we identify the very
bright, naked-eye star ν Indi as an indicator of the age of the early in situ
population of the Galaxy. We combine asteroseismic, spectroscopic, astrometric
and kinematic observations to show that this metal-poor, alpha-element-rich star
was an indigenous member of the halo, and we measure its age to be 11.0±0.7 (stat)
±0.8 (sys) billion years. The star bears hallmarks consistent with having been
kinematically heated by the Gaia–Enceladus collision. Its age implies that the
earliest the merger could have begun was 11.6 and 13.2 billion years ago, at 68%
and 95% confidence, respectively. Computations based on hierarchical cosmological
models slightly reduce the above limits.
acknowledgement: This paper includes data collected by the TESS mission, which are
publicly available from the Mikulski Archive for Space Telescopes (MAST). Resources
supporting this work were provided by the NASA High-End Computing (HEC) Program
through the NASA Advanced Supercomputing (NAS) Division at Ames Research Center
for the production of the SPOC data products. W.J.C. acknowledges support from the
UK Science and Technology Facilities Council (STFC) and UK Space Agency. Funding
for the Stellar Astrophysics Centre is provided by The Danish National Research
Foundation (grant agreement number DNRF106). This research was partially conducted
during the Exostar19 programme at the Kavli Institute for Theoretical Physics at
UC Santa Barbara, which was supported in part by the National Science Foundation
under grant number NSF PHY-1748958. A.M., J.T.M., F.V. and J.M. acknowledge support
from the ERC Consolidator Grant funding scheme (project ASTEROCHRONOMETRY, grant
agreement number 772293). F.V. acknowledges the support of a Fellowship from the
Center for Cosmology and AstroParticle Physics at The Ohio State University. W.H.B.
and M.B.N. acknowledge support from the UK Space Agency. K.J.B. is supported by
the National Science Foundation under award AST-1903828. M.B.N. acknowledges partial
support from the NYU Abu Dhabi Center for Space Science under grant number G1502.
A.M.S. is partially supported by the Spanish Government (ESP2017-82674-R) and Generalitat
de Catalunya (2017-SGR-1131). T.M. acknowledges financial support from Belspo for
contract PRODEX PLATO. H.K. acknowledges support from the European Social Fund via
the Lithuanian Science Council grant number 09.3.3-LMT-K-712-01-0103. S.B. acknowledges
support from NSF grant AST-1514676 and NASA grant 80NSSC19K0374. V.S.A. acknowledges
support from the Independent Research Fund Denmark (research grant 7027-00096B).
D.H. acknowledges support by the National Aeronautics and Space Administration (80NSSC18K1585,
80NSSC19K0379) awarded through the TESS Guest Investigator Program and by the National
Science Foundation (AST-1717000). T.S.M. acknowledges support from a visiting fellowship
at the Max Planck Institute for Solar System Research. Computational resources were
provided through XSEDE allocation TG-AST090107. D.L.B. acknowledges support from
NASA under grant NNX16AB76G. T.L.C. acknowledges support from the European Union’s
Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
grant agreement number 792848 (PULSATION). This work was supported by FCT/MCTES
through national funds (PIDDAC) by means of grant UID/FIS/04434/2019. K.J.B., S.H.,
J.S.K. and N.T. are supported by the European Research Council under the European
Community’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement number
338251 (StellarAges). E.C. is funded by the European Union’s Horizon 2020 research
and innovation program under the Marie Sklodowska-Curie grant agreement number 664931.
L.G.-C. acknowledges support from the MINECO FPI-SO doctoral research project SEV-2015-0548-17-2
and predoctoral contract BES-2017-082610. P.G. is supported by the German space
agency (Deutsches Zentrum für Luft- und Raumfahrt) under PLATO data grant 50OO1501.
R.K. acknowledges support from the UK Science and Technology Facilities Council
(STFC), under consolidated grant ST/L000733/1. M.S.L. is supported by the Carlsberg
Foundation (grant agreement number CF17-076). Z.C.O., S.O. and M.Y. acknowledge
support from the Scientific and Technological Research Council of Turkey (TÜBİTAK:118F352).
S.M. acknowledges support from the Spanish ministry through the Ramon y Cajal fellowship
number RYC-2015-17697. T.S.R. acknowledges financial support from Premiale 2015
MITiC (PI B. Garilli). R.Sz. acknowledges the support from NKFIH grant project No.
K-115709, and the Lendület program of the Hungarian Academy of Science (project
number 2018-7/2019). J.T. acknowledges support was provided by NASA through the
NASA Hubble Fellowship grant number 51424 awarded by the Space Telescope Science
Institute, which is operated by the Association of Universities for Research in
Astronomy, Inc., for NASA, under contract NAS5-26555. This work was supported by
FEDER through COMPETE2020 (POCI-01-0145-FEDER-030389. A.M.B. acknowledges funding
from the European Union’s Horizon 2020 research and innovation program under the
Marie Sklodowska-Curie grant agreement No 749962 (project THOT). A.M. and P.R. acknowledge
the support of the Government of India, Department of Atomic Energy, under Project
No. 12-R&D-TFR-6.04-0600. K.J.B. is an NSF Astronomy and Astrophysics Postdoctoral
Fellow and DIRAC Fellow.
article_processing_charge: No
article_type: letter_note
author:
- first_name: William J.
full_name: Chaplin, William J.
last_name: Chaplin
- first_name: Aldo M.
full_name: Serenelli, Aldo M.
last_name: Serenelli
- first_name: Andrea
full_name: Miglio, Andrea
last_name: Miglio
- first_name: Thierry
full_name: Morel, Thierry
last_name: Morel
- first_name: J. Ted
full_name: Mackereth, J. Ted
last_name: Mackereth
- first_name: Fiorenzo
full_name: Vincenzo, Fiorenzo
last_name: Vincenzo
- first_name: Hans
full_name: Kjeldsen, Hans
last_name: Kjeldsen
- first_name: Sarbani
full_name: Basu, Sarbani
last_name: Basu
- first_name: Warrick H.
full_name: Ball, Warrick H.
last_name: Ball
- first_name: Amalie
full_name: Stokholm, Amalie
last_name: Stokholm
- first_name: Kuldeep
full_name: Verma, Kuldeep
last_name: Verma
- first_name: Jakob Rørsted
full_name: Mosumgaard, Jakob Rørsted
last_name: Mosumgaard
- first_name: Victor
full_name: Silva Aguirre, Victor
last_name: Silva Aguirre
- first_name: Anwesh
full_name: Mazumdar, Anwesh
last_name: Mazumdar
- first_name: Pritesh
full_name: Ranadive, Pritesh
last_name: Ranadive
- first_name: H. M.
full_name: Antia, H. M.
last_name: Antia
- first_name: Yveline
full_name: Lebreton, Yveline
last_name: Lebreton
- first_name: Joel
full_name: Ong, Joel
last_name: Ong
- first_name: Thierry
full_name: Appourchaux, Thierry
last_name: Appourchaux
- first_name: Timothy R.
full_name: Bedding, Timothy R.
last_name: Bedding
- first_name: Jørgen
full_name: Christensen-Dalsgaard, Jørgen
last_name: Christensen-Dalsgaard
- first_name: Orlagh
full_name: Creevey, Orlagh
last_name: Creevey
- first_name: Rafael A.
full_name: García, Rafael A.
last_name: García
- first_name: Rasmus
full_name: Handberg, Rasmus
last_name: Handberg
- first_name: Daniel
full_name: Huber, Daniel
last_name: Huber
- first_name: Steven D.
full_name: Kawaler, Steven D.
last_name: Kawaler
- first_name: Mikkel N.
full_name: Lund, Mikkel N.
last_name: Lund
- first_name: Travis S.
full_name: Metcalfe, Travis S.
last_name: Metcalfe
- first_name: Keivan G.
full_name: Stassun, Keivan G.
last_name: Stassun
- first_name: Michäel
full_name: Bazot, Michäel
last_name: Bazot
- first_name: Paul G.
full_name: Beck, Paul G.
last_name: Beck
- first_name: Keaton J.
full_name: Bell, Keaton J.
last_name: Bell
- first_name: Maria
full_name: Bergemann, Maria
last_name: Bergemann
- first_name: Derek L.
full_name: Buzasi, Derek L.
last_name: Buzasi
- first_name: Othman
full_name: Benomar, Othman
last_name: Benomar
- first_name: Diego
full_name: Bossini, Diego
last_name: Bossini
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
- first_name: Tiago L.
full_name: Campante, Tiago L.
last_name: Campante
- first_name: Zeynep Çelik
full_name: Orhan, Zeynep Çelik
last_name: Orhan
- first_name: Enrico
full_name: Corsaro, Enrico
last_name: Corsaro
- first_name: Lucía
full_name: González-Cuesta, Lucía
last_name: González-Cuesta
- first_name: Guy R.
full_name: Davies, Guy R.
last_name: Davies
- first_name: Maria Pia
full_name: Di Mauro, Maria Pia
last_name: Di Mauro
- first_name: Ricky
full_name: Egeland, Ricky
last_name: Egeland
- first_name: Yvonne P.
full_name: Elsworth, Yvonne P.
last_name: Elsworth
- first_name: Patrick
full_name: Gaulme, Patrick
last_name: Gaulme
- first_name: Hamed
full_name: Ghasemi, Hamed
last_name: Ghasemi
- first_name: Zhao
full_name: Guo, Zhao
last_name: Guo
- first_name: Oliver J.
full_name: Hall, Oliver J.
last_name: Hall
- first_name: Amir
full_name: Hasanzadeh, Amir
last_name: Hasanzadeh
- first_name: Saskia
full_name: Hekker, Saskia
last_name: Hekker
- first_name: Rachel
full_name: Howe, Rachel
last_name: Howe
- first_name: Jon M.
full_name: Jenkins, Jon M.
last_name: Jenkins
- first_name: Antonio
full_name: Jiménez, Antonio
last_name: Jiménez
- first_name: René
full_name: Kiefer, René
last_name: Kiefer
- first_name: James S.
full_name: Kuszlewicz, James S.
last_name: Kuszlewicz
- first_name: Thomas
full_name: Kallinger, Thomas
last_name: Kallinger
- first_name: David W.
full_name: Latham, David W.
last_name: Latham
- first_name: Mia S.
full_name: Lundkvist, Mia S.
last_name: Lundkvist
- first_name: Savita
full_name: Mathur, Savita
last_name: Mathur
- first_name: Josefina
full_name: Montalbán, Josefina
last_name: Montalbán
- first_name: Benoit
full_name: Mosser, Benoit
last_name: Mosser
- first_name: Andres Moya
full_name: Bedón, Andres Moya
last_name: Bedón
- first_name: Martin Bo
full_name: Nielsen, Martin Bo
last_name: Nielsen
- first_name: Sibel
full_name: Örtel, Sibel
last_name: Örtel
- first_name: Ben M.
full_name: Rendle, Ben M.
last_name: Rendle
- first_name: George R.
full_name: Ricker, George R.
last_name: Ricker
- first_name: Thaíse S.
full_name: Rodrigues, Thaíse S.
last_name: Rodrigues
- first_name: Ian W.
full_name: Roxburgh, Ian W.
last_name: Roxburgh
- first_name: Hossein
full_name: Safari, Hossein
last_name: Safari
- first_name: Mathew
full_name: Schofield, Mathew
last_name: Schofield
- first_name: Sara
full_name: Seager, Sara
last_name: Seager
- first_name: Barry
full_name: Smalley, Barry
last_name: Smalley
- first_name: Dennis
full_name: Stello, Dennis
last_name: Stello
- first_name: Róbert
full_name: Szabó, Róbert
last_name: Szabó
- first_name: Jamie
full_name: Tayar, Jamie
last_name: Tayar
- first_name: Nathalie
full_name: Themeßl, Nathalie
last_name: Themeßl
- first_name: Alexandra E. L.
full_name: Thomas, Alexandra E. L.
last_name: Thomas
- first_name: Roland K.
full_name: Vanderspek, Roland K.
last_name: Vanderspek
- first_name: Walter E.
full_name: van Rossem, Walter E.
last_name: van Rossem
- first_name: Mathieu
full_name: Vrard, Mathieu
last_name: Vrard
- first_name: Achim
full_name: Weiss, Achim
last_name: Weiss
- first_name: Timothy R.
full_name: White, Timothy R.
last_name: White
- first_name: Joshua N.
full_name: Winn, Joshua N.
last_name: Winn
- first_name: Mutlu
full_name: Yıldız, Mutlu
last_name: Yıldız
citation:
ama: Chaplin WJ, Serenelli AM, Miglio A, et al. Age dating of an early Milky Way
merger via asteroseismology of the naked-eye star ν Indi. Nature Astronomy.
2020;4(4):382-389. doi:10.1038/s41550-019-0975-9
apa: Chaplin, W. J., Serenelli, A. M., Miglio, A., Morel, T., Mackereth, J. T.,
Vincenzo, F., … Yıldız, M. (2020). Age dating of an early Milky Way merger via
asteroseismology of the naked-eye star ν Indi. Nature Astronomy. Springer
Nature. https://doi.org/10.1038/s41550-019-0975-9
chicago: Chaplin, William J., Aldo M. Serenelli, Andrea Miglio, Thierry Morel, J.
Ted Mackereth, Fiorenzo Vincenzo, Hans Kjeldsen, et al. “Age Dating of an Early
Milky Way Merger via Asteroseismology of the Naked-Eye Star ν Indi.” Nature
Astronomy. Springer Nature, 2020. https://doi.org/10.1038/s41550-019-0975-9.
ieee: W. J. Chaplin et al., “Age dating of an early Milky Way merger via
asteroseismology of the naked-eye star ν Indi,” Nature Astronomy, vol.
4, no. 4. Springer Nature, pp. 382–389, 2020.
ista: Chaplin WJ, Serenelli AM, Miglio A, Morel T, Mackereth JT, Vincenzo F, Kjeldsen
H, Basu S, Ball WH, Stokholm A, Verma K, Mosumgaard JR, Silva Aguirre V, Mazumdar
A, Ranadive P, Antia HM, Lebreton Y, Ong J, Appourchaux T, Bedding TR, Christensen-Dalsgaard
J, Creevey O, García RA, Handberg R, Huber D, Kawaler SD, Lund MN, Metcalfe TS,
Stassun KG, Bazot M, Beck PG, Bell KJ, Bergemann M, Buzasi DL, Benomar O, Bossini
D, Bugnet LA, Campante TL, Orhan ZÇ, Corsaro E, González-Cuesta L, Davies GR,
Di Mauro MP, Egeland R, Elsworth YP, Gaulme P, Ghasemi H, Guo Z, Hall OJ, Hasanzadeh
A, Hekker S, Howe R, Jenkins JM, Jiménez A, Kiefer R, Kuszlewicz JS, Kallinger
T, Latham DW, Lundkvist MS, Mathur S, Montalbán J, Mosser B, Bedón AM, Nielsen
MB, Örtel S, Rendle BM, Ricker GR, Rodrigues TS, Roxburgh IW, Safari H, Schofield
M, Seager S, Smalley B, Stello D, Szabó R, Tayar J, Themeßl N, Thomas AEL, Vanderspek
RK, van Rossem WE, Vrard M, Weiss A, White TR, Winn JN, Yıldız M. 2020. Age dating
of an early Milky Way merger via asteroseismology of the naked-eye star ν Indi.
Nature Astronomy. 4(4), 382–389.
mla: Chaplin, William J., et al. “Age Dating of an Early Milky Way Merger via Asteroseismology
of the Naked-Eye Star ν Indi.” Nature Astronomy, vol. 4, no. 4, Springer
Nature, 2020, pp. 382–89, doi:10.1038/s41550-019-0975-9.
short: W.J. Chaplin, A.M. Serenelli, A. Miglio, T. Morel, J.T. Mackereth, F. Vincenzo,
H. Kjeldsen, S. Basu, W.H. Ball, A. Stokholm, K. Verma, J.R. Mosumgaard, V. Silva
Aguirre, A. Mazumdar, P. Ranadive, H.M. Antia, Y. Lebreton, J. Ong, T. Appourchaux,
T.R. Bedding, J. Christensen-Dalsgaard, O. Creevey, R.A. García, R. Handberg,
D. Huber, S.D. Kawaler, M.N. Lund, T.S. Metcalfe, K.G. Stassun, M. Bazot, P.G.
Beck, K.J. Bell, M. Bergemann, D.L. Buzasi, O. Benomar, D. Bossini, L.A. Bugnet,
T.L. Campante, Z.Ç. Orhan, E. Corsaro, L. González-Cuesta, G.R. Davies, M.P. Di
Mauro, R. Egeland, Y.P. Elsworth, P. Gaulme, H. Ghasemi, Z. Guo, O.J. Hall, A.
Hasanzadeh, S. Hekker, R. Howe, J.M. Jenkins, A. Jiménez, R. Kiefer, J.S. Kuszlewicz,
T. Kallinger, D.W. Latham, M.S. Lundkvist, S. Mathur, J. Montalbán, B. Mosser,
A.M. Bedón, M.B. Nielsen, S. Örtel, B.M. Rendle, G.R. Ricker, T.S. Rodrigues,
I.W. Roxburgh, H. Safari, M. Schofield, S. Seager, B. Smalley, D. Stello, R. Szabó,
J. Tayar, N. Themeßl, A.E.L. Thomas, R.K. Vanderspek, W.E. van Rossem, M. Vrard,
A. Weiss, T.R. White, J.N. Winn, M. Yıldız, Nature Astronomy 4 (2020) 382–389.
date_created: 2022-07-18T13:36:19Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2022-08-22T07:08:29Z
day: '01'
doi: 10.1038/s41550-019-0975-9
extern: '1'
external_id:
arxiv:
- '2001.04653'
intvolume: ' 4'
issue: '4'
keyword:
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2001.04653
month: '04'
oa: 1
oa_version: Preprint
page: 382-389
publication: Nature Astronomy
publication_identifier:
eissn:
- 2397-3366
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Age dating of an early Milky Way merger via asteroseismology of the naked-eye
star ν Indi
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2020'
...
---
_id: '11612'
abstract:
- lang: eng
text: Since the onset of the "space revolution" of high-precision high-cadence photometry,
asteroseismology has been demonstrated as a powerful tool for informing Galactic
archeology investigations. The launch of the NASA Transiting Exoplanet Survey
Satellite (TESS) mission has enabled seismic-based inferences to go full sky—providing
a clear advantage for large ensemble studies of the different Milky Way components.
Here we demonstrate its potential for investigating the Galaxy by carrying out
the first asteroseismic ensemble study of red giant stars observed by TESS. We
use a sample of 25 stars for which we measure their global asteroseimic observables
and estimate their fundamental stellar properties, such as radius, mass, and age.
Significant improvements are seen in the uncertainties of our estimates when combining
seismic observables from TESS with astrometric measurements from the Gaia mission
compared to when the seismology and astrometry are applied separately. Specifically,
when combined we show that stellar radii can be determined to a precision of a
few percent, masses to 5%–10%, and ages to the 20% level. This is comparable to
the precision typically obtained using end-of-mission Kepler data.
acknowledgement: 'This Letter includes data collected by the TESS mission, which are
publicly available from the Mikulski Archive for Space Telescopes (MAST). Funding
for the TESS mission is provided by NASA''s Science Mission directorate. Funding
for the TESS Asteroseismic Science Operations Centre is provided by the Danish National
Research Foundation (grant agreement No. DNRF106), ESA PRODEX (PEA 4000119301),
and Stellar Astrophysics Centre (SAC) at Aarhus University. V.S.A. acknowledges
support from the Independent Research Fund Denmark (Research grant 7027-00096B).
D.B. is supported in the form of work contract FCT/MCTES through national funds
and by FEDER through COMPETE2020 in connection to these grants: UID/FIS/04434/2019;
PTDC/FIS-AST/30389/2017 & POCI-01-0145-FEDER-030389. L.B., R.A.G., and B.M. acknowledge
the support from the CNES/PLATO grant. D.B. acknowledges NASA grant NNX16AB76G.
T.L.C. acknowledges support from the European Union''s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement No. 792848
(PULSATION). This work was supported by FCT/MCTES through national funds (UID/FIS/04434/2019).
E.C. is funded by the European Union''s Horizon 2020 research and innovation program
under the Marie Skłodowska-Curie grant agreement No. 664931. R.H. and M.N.L. acknowledge
the support of the ESA PRODEX programme. T.S.R. acknowledges financial support from
Premiale 2015 MITiC (PI B. Garilli). K.J.B. is supported by the National Science
Foundation under Award AST-1903828. M.S.L. is supported by the Carlsberg Foundation
(grant agreement No. CF17-0760). M.C. is funded by FCT//MCTES through national funds
and by FEDER through COMPETE2020 through these grants: UID/FIS/04434/2019, PTDC/FIS-AST/30389/2017
& POCI-01-0145-FEDER-030389, CEECIND/02619/2017. The research leading to the presented
results has received funding from the European Research Council under the European
Community''s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no
338251 (StellarAges). A.M. acknowledges support from the European Research Council
Consolidator Grant funding scheme (project ASTEROCHRONOMETRY, grant agreement No.
772293, http://www.asterochronometry.eu). A.M.S. is partially supported by MINECO
grant ESP2017-82674-R. J.C.S. acknowledges funding support from Spanish public funds
for research under projects ESP2017-87676-2-2, and from project RYC-2012-09913 under
the ''Ramón y Cajal'' program of the Spanish Ministry of Science and Education.
Resources supporting this work were provided by the NASA High-End Computing (HEC)
Program through the NASA Advanced Supercomputing (NAS) Division at Ames Research
Center for the production of the SPOC data products.'
article_number: L34
article_processing_charge: No
article_type: original
author:
- first_name: Víctor Silva
full_name: Aguirre, Víctor Silva
last_name: Aguirre
- first_name: Dennis
full_name: Stello, Dennis
last_name: Stello
- first_name: Amalie
full_name: Stokholm, Amalie
last_name: Stokholm
- first_name: Jakob R.
full_name: Mosumgaard, Jakob R.
last_name: Mosumgaard
- first_name: Warrick H.
full_name: Ball, Warrick H.
last_name: Ball
- first_name: Sarbani
full_name: Basu, Sarbani
last_name: Basu
- first_name: Diego
full_name: Bossini, Diego
last_name: Bossini
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
- first_name: Derek
full_name: Buzasi, Derek
last_name: Buzasi
- first_name: Tiago L.
full_name: Campante, Tiago L.
last_name: Campante
- first_name: Lindsey
full_name: Carboneau, Lindsey
last_name: Carboneau
- first_name: William J.
full_name: Chaplin, William J.
last_name: Chaplin
- first_name: Enrico
full_name: Corsaro, Enrico
last_name: Corsaro
- first_name: Guy R.
full_name: Davies, Guy R.
last_name: Davies
- first_name: Yvonne
full_name: Elsworth, Yvonne
last_name: Elsworth
- first_name: Rafael A.
full_name: García, Rafael A.
last_name: García
- first_name: Patrick
full_name: Gaulme, Patrick
last_name: Gaulme
- first_name: Oliver J.
full_name: Hall, Oliver J.
last_name: Hall
- first_name: Rasmus
full_name: Handberg, Rasmus
last_name: Handberg
- first_name: Marc
full_name: Hon, Marc
last_name: Hon
- first_name: Thomas
full_name: Kallinger, Thomas
last_name: Kallinger
- first_name: Liu
full_name: Kang, Liu
last_name: Kang
- first_name: Mikkel N.
full_name: Lund, Mikkel N.
last_name: Lund
- first_name: Savita
full_name: Mathur, Savita
last_name: Mathur
- first_name: Alexey
full_name: Mints, Alexey
last_name: Mints
- first_name: Benoit
full_name: Mosser, Benoit
last_name: Mosser
- first_name: Zeynep
full_name: Çelik Orhan, Zeynep
last_name: Çelik Orhan
- first_name: Thaíse S.
full_name: Rodrigues, Thaíse S.
last_name: Rodrigues
- first_name: Mathieu
full_name: Vrard, Mathieu
last_name: Vrard
- first_name: Mutlu
full_name: Yıldız, Mutlu
last_name: Yıldız
- first_name: Joel C.
full_name: Zinn, Joel C.
last_name: Zinn
- first_name: Sibel
full_name: Örtel, Sibel
last_name: Örtel
- first_name: Paul G.
full_name: Beck, Paul G.
last_name: Beck
- first_name: Keaton J.
full_name: Bell, Keaton J.
last_name: Bell
- first_name: Zhao
full_name: Guo, Zhao
last_name: Guo
- first_name: Chen
full_name: Jiang, Chen
last_name: Jiang
- first_name: James S.
full_name: Kuszlewicz, James S.
last_name: Kuszlewicz
- first_name: Charles A.
full_name: Kuehn, Charles A.
last_name: Kuehn
- first_name: Tanda
full_name: Li, Tanda
last_name: Li
- first_name: Mia S.
full_name: Lundkvist, Mia S.
last_name: Lundkvist
- first_name: Marc
full_name: Pinsonneault, Marc
last_name: Pinsonneault
- first_name: Jamie
full_name: Tayar, Jamie
last_name: Tayar
- first_name: Margarida S.
full_name: Cunha, Margarida S.
last_name: Cunha
- first_name: Saskia
full_name: Hekker, Saskia
last_name: Hekker
- first_name: Daniel
full_name: Huber, Daniel
last_name: Huber
- first_name: Andrea
full_name: Miglio, Andrea
last_name: Miglio
- first_name: Mario J. P.
full_name: F. G. Monteiro, Mario J. P.
last_name: F. G. Monteiro
- first_name: Ditte
full_name: Slumstrup, Ditte
last_name: Slumstrup
- first_name: Mark L.
full_name: Winther, Mark L.
last_name: Winther
- first_name: George
full_name: Angelou, George
last_name: Angelou
- first_name: Othman
full_name: Benomar, Othman
last_name: Benomar
- first_name: Attila
full_name: Bódi, Attila
last_name: Bódi
- first_name: Bruno L.
full_name: De Moura, Bruno L.
last_name: De Moura
- first_name: Sébastien
full_name: Deheuvels, Sébastien
last_name: Deheuvels
- first_name: Aliz
full_name: Derekas, Aliz
last_name: Derekas
- first_name: Maria Pia
full_name: Di Mauro, Maria Pia
last_name: Di Mauro
- first_name: Marc-Antoine
full_name: Dupret, Marc-Antoine
last_name: Dupret
- first_name: Antonio
full_name: Jiménez, Antonio
last_name: Jiménez
- first_name: Yveline
full_name: Lebreton, Yveline
last_name: Lebreton
- first_name: Jaymie
full_name: Matthews, Jaymie
last_name: Matthews
- first_name: Nicolas
full_name: Nardetto, Nicolas
last_name: Nardetto
- first_name: Jose D.
full_name: do Nascimento, Jose D.
last_name: do Nascimento
- first_name: Filipe
full_name: Pereira, Filipe
last_name: Pereira
- first_name: Luisa F.
full_name: Rodríguez Díaz, Luisa F.
last_name: Rodríguez Díaz
- first_name: Aldo M.
full_name: Serenelli, Aldo M.
last_name: Serenelli
- first_name: Emanuele
full_name: Spitoni, Emanuele
last_name: Spitoni
- first_name: Edita
full_name: Stonkutė, Edita
last_name: Stonkutė
- first_name: Juan Carlos
full_name: Suárez, Juan Carlos
last_name: Suárez
- first_name: Robert
full_name: Szabó, Robert
last_name: Szabó
- first_name: Vincent
full_name: Van Eylen, Vincent
last_name: Van Eylen
- first_name: Rita
full_name: Ventura, Rita
last_name: Ventura
- first_name: Kuldeep
full_name: Verma, Kuldeep
last_name: Verma
- first_name: Achim
full_name: Weiss, Achim
last_name: Weiss
- first_name: Tao
full_name: Wu, Tao
last_name: Wu
- first_name: Thomas
full_name: Barclay, Thomas
last_name: Barclay
- first_name: Jørgen
full_name: Christensen-Dalsgaard, Jørgen
last_name: Christensen-Dalsgaard
- first_name: Jon M.
full_name: Jenkins, Jon M.
last_name: Jenkins
- first_name: Hans
full_name: Kjeldsen, Hans
last_name: Kjeldsen
- first_name: George R.
full_name: Ricker, George R.
last_name: Ricker
- first_name: Sara
full_name: Seager, Sara
last_name: Seager
- first_name: Roland
full_name: Vanderspek, Roland
last_name: Vanderspek
citation:
ama: 'Aguirre VS, Stello D, Stokholm A, et al. Detection and characterization of
oscillating red giants: First results from the TESS satellite. The Astrophysical
Journal Letters. 2020;889(2). doi:10.3847/2041-8213/ab6443'
apa: 'Aguirre, V. S., Stello, D., Stokholm, A., Mosumgaard, J. R., Ball, W. H.,
Basu, S., … Vanderspek, R. (2020). Detection and characterization of oscillating
red giants: First results from the TESS satellite. The Astrophysical Journal
Letters. IOP Publishing. https://doi.org/10.3847/2041-8213/ab6443'
chicago: 'Aguirre, Víctor Silva, Dennis Stello, Amalie Stokholm, Jakob R. Mosumgaard,
Warrick H. Ball, Sarbani Basu, Diego Bossini, et al. “Detection and Characterization
of Oscillating Red Giants: First Results from the TESS Satellite.” The Astrophysical
Journal Letters. IOP Publishing, 2020. https://doi.org/10.3847/2041-8213/ab6443.'
ieee: 'V. S. Aguirre et al., “Detection and characterization of oscillating
red giants: First results from the TESS satellite,” The Astrophysical Journal
Letters, vol. 889, no. 2. IOP Publishing, 2020.'
ista: 'Aguirre VS, Stello D, Stokholm A, Mosumgaard JR, Ball WH, Basu S, Bossini
D, Bugnet LA, Buzasi D, Campante TL, Carboneau L, Chaplin WJ, Corsaro E, Davies
GR, Elsworth Y, García RA, Gaulme P, Hall OJ, Handberg R, Hon M, Kallinger T,
Kang L, Lund MN, Mathur S, Mints A, Mosser B, Çelik Orhan Z, Rodrigues TS, Vrard
M, Yıldız M, Zinn JC, Örtel S, Beck PG, Bell KJ, Guo Z, Jiang C, Kuszlewicz JS,
Kuehn CA, Li T, Lundkvist MS, Pinsonneault M, Tayar J, Cunha MS, Hekker S, Huber
D, Miglio A, F. G. Monteiro MJP, Slumstrup D, Winther ML, Angelou G, Benomar O,
Bódi A, De Moura BL, Deheuvels S, Derekas A, Di Mauro MP, Dupret M-A, Jiménez
A, Lebreton Y, Matthews J, Nardetto N, do Nascimento JD, Pereira F, Rodríguez
Díaz LF, Serenelli AM, Spitoni E, Stonkutė E, Suárez JC, Szabó R, Van Eylen V,
Ventura R, Verma K, Weiss A, Wu T, Barclay T, Christensen-Dalsgaard J, Jenkins
JM, Kjeldsen H, Ricker GR, Seager S, Vanderspek R. 2020. Detection and characterization
of oscillating red giants: First results from the TESS satellite. The Astrophysical
Journal Letters. 889(2), L34.'
mla: 'Aguirre, Víctor Silva, et al. “Detection and Characterization of Oscillating
Red Giants: First Results from the TESS Satellite.” The Astrophysical Journal
Letters, vol. 889, no. 2, L34, IOP Publishing, 2020, doi:10.3847/2041-8213/ab6443.'
short: V.S. Aguirre, D. Stello, A. Stokholm, J.R. Mosumgaard, W.H. Ball, S. Basu,
D. Bossini, L.A. Bugnet, D. Buzasi, T.L. Campante, L. Carboneau, W.J. Chaplin,
E. Corsaro, G.R. Davies, Y. Elsworth, R.A. García, P. Gaulme, O.J. Hall, R. Handberg,
M. Hon, T. Kallinger, L. Kang, M.N. Lund, S. Mathur, A. Mints, B. Mosser, Z. Çelik
Orhan, T.S. Rodrigues, M. Vrard, M. Yıldız, J.C. Zinn, S. Örtel, P.G. Beck, K.J.
Bell, Z. Guo, C. Jiang, J.S. Kuszlewicz, C.A. Kuehn, T. Li, M.S. Lundkvist, M.
Pinsonneault, J. Tayar, M.S. Cunha, S. Hekker, D. Huber, A. Miglio, M.J.P. F.
G. Monteiro, D. Slumstrup, M.L. Winther, G. Angelou, O. Benomar, A. Bódi, B.L.
De Moura, S. Deheuvels, A. Derekas, M.P. Di Mauro, M.-A. Dupret, A. Jiménez, Y.
Lebreton, J. Matthews, N. Nardetto, J.D. do Nascimento, F. Pereira, L.F. Rodríguez
Díaz, A.M. Serenelli, E. Spitoni, E. Stonkutė, J.C. Suárez, R. Szabó, V. Van Eylen,
R. Ventura, K. Verma, A. Weiss, T. Wu, T. Barclay, J. Christensen-Dalsgaard, J.M.
Jenkins, H. Kjeldsen, G.R. Ricker, S. Seager, R. Vanderspek, The Astrophysical
Journal Letters 889 (2020).
date_created: 2022-07-18T13:52:54Z
date_published: 2020-02-01T00:00:00Z
date_updated: 2022-08-22T07:25:51Z
day: '01'
doi: 10.3847/2041-8213/ab6443
extern: '1'
external_id:
arxiv:
- '1912.07604'
intvolume: ' 889'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1912.07604
month: '02'
oa: 1
oa_version: Preprint
publication: The Astrophysical Journal Letters
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Detection and characterization of oscillating red giants: First results from
the TESS satellite'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 889
year: '2020'
...
---
_id: '11622'
abstract:
- lang: eng
text: 'The recent discovery of low-amplitude dipolar oscillation mixed modes in
massive red giants indicates the presence of a missing physical process inside
their cores. Stars more massive than ∼ 1.3 M⊙ are known to develop a convective
core during the main-sequence: the dynamo process triggered by this convection
could be the origin of a strong magnetic field inside the core of the star, trapped
when it becomes stably stratified and for the rest of its evolution. The presence
of highly magnetized white dwarfs strengthens the hypothesis of buried fossil
magnetic fields inside the core of evolved low-mass stars. If such a fossil field
exists, it should affect the mixed modes of red giants as they are sensitive to
processes affecting the deepest layers of these stars. The impact of a magnetic
field on dipolar oscillations modes was one of Pr. Michael J. Thompson’s research
topics during the 90s when preparing the helioseismic SoHO space mission. As the
detection of gravity modes in the Sun is still controversial, the investigation
of the solar oscillation modes did not provide any hint of the existence of a
magnetic field in the solar radiative core. Today we have access to the core of
evolved stars thanks to the asteroseismic observation of mixed modes from CoRoT,
Kepler, K2 and TESS missions. The idea of applying and generalizing the work done
for the Sun came from discussions with Pr. Michael Thompson in early 2018 before
we lost him. Following the path we drew together, we theoretically investigate
the effect of a stable axisymmetric mixed poloidal and toroidal magnetic field,
aligned with the rotation axis of the star, on the mixed modes frequencies of
a typical evolved low-mass star. This enables us to estimate the magnetic perturbations
to the eigenfrequencies of mixed dipolar modes, depending on the magnetic field
strength and the evolutionary state of the star. We conclude that strong magnetic
fields of ∼ 1MG should perturb the mixed-mode frequency pattern enough for its
effects to be detectable inside current asteroseismic data.'
acknowledgement: The authors of this work acknowledge the support received from the
PLATO CNES grant, the National Aeronautics and Space Administration under Grant
NNX15AF13G, by the National Science Foundation grant AST-1411685, the Ramon y Cajal
fellowship number RYC-2015-17697, the ERC SPIRE grant (647383), and the Fundation
L’Oréal-Unesco-Académie des sciences.
alternative_title:
- Astrophysics and Space Science Proceedings
article_processing_charge: No
author:
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
- first_name: V.
full_name: Prat, V.
last_name: Prat
- first_name: S.
full_name: Mathis, S.
last_name: Mathis
- first_name: R. A.
full_name: García, R. A.
last_name: García
- first_name: S.
full_name: Mathur, S.
last_name: Mathur
- first_name: K.
full_name: Augustson, K.
last_name: Augustson
- first_name: C.
full_name: Neiner, C.
last_name: Neiner
- first_name: M. J.
full_name: Thompson, M. J.
last_name: Thompson
citation:
ama: 'Bugnet LA, Prat V, Mathis S, et al. The impact of a fossil magnetic field
on dipolar mixed-mode frequencies in sub- and red-giant stars. In: Monteiro M,
Garcia RA, Christensen-Dalsgaard J, McIntosh SW, eds. Dynamics of the Sun and
Stars. Vol 57. 1st ed. ASSSP. Cham: Springer Nature; 2020:251-257. doi:10.1007/978-3-030-55336-4_33'
apa: 'Bugnet, L. A., Prat, V., Mathis, S., García, R. A., Mathur, S., Augustson,
K., … Thompson, M. J. (2020). The impact of a fossil magnetic field on dipolar
mixed-mode frequencies in sub- and red-giant stars. In M. Monteiro, R. A. Garcia,
J. Christensen-Dalsgaard, & S. W. McIntosh (Eds.), Dynamics of the Sun
and Stars (1st ed., Vol. 57, pp. 251–257). Cham: Springer Nature. https://doi.org/10.1007/978-3-030-55336-4_33'
chicago: 'Bugnet, Lisa Annabelle, V. Prat, S. Mathis, R. A. García, S. Mathur, K.
Augustson, C. Neiner, and M. J. Thompson. “The Impact of a Fossil Magnetic Field
on Dipolar Mixed-Mode Frequencies in Sub- and Red-Giant Stars.” In Dynamics
of the Sun and Stars, edited by Mario Monteiro, Rafael A Garcia, Jorgen Christensen-Dalsgaard,
and Scott W McIntosh, 1st ed., 57:251–57. ASSSP. Cham: Springer Nature, 2020.
https://doi.org/10.1007/978-3-030-55336-4_33.'
ieee: 'L. A. Bugnet et al., “The impact of a fossil magnetic field on dipolar
mixed-mode frequencies in sub- and red-giant stars,” in Dynamics of the Sun
and Stars, 1st ed., vol. 57, M. Monteiro, R. A. Garcia, J. Christensen-Dalsgaard,
and S. W. McIntosh, Eds. Cham: Springer Nature, 2020, pp. 251–257.'
ista: 'Bugnet LA, Prat V, Mathis S, García RA, Mathur S, Augustson K, Neiner C,
Thompson MJ. 2020.The impact of a fossil magnetic field on dipolar mixed-mode
frequencies in sub- and red-giant stars. In: Dynamics of the Sun and Stars. Astrophysics
and Space Science Proceedings, vol. 57, 251–257.'
mla: Bugnet, Lisa Annabelle, et al. “The Impact of a Fossil Magnetic Field on Dipolar
Mixed-Mode Frequencies in Sub- and Red-Giant Stars.” Dynamics of the Sun and
Stars, edited by Mario Monteiro et al., 1st ed., vol. 57, Springer Nature,
2020, pp. 251–57, doi:10.1007/978-3-030-55336-4_33.
short: L.A. Bugnet, V. Prat, S. Mathis, R.A. García, S. Mathur, K. Augustson, C.
Neiner, M.J. Thompson, in:, M. Monteiro, R.A. Garcia, J. Christensen-Dalsgaard,
S.W. McIntosh (Eds.), Dynamics of the Sun and Stars, 1st ed., Springer Nature,
Cham, 2020, pp. 251–257.
date_created: 2022-07-19T08:25:41Z
date_published: 2020-12-19T00:00:00Z
date_updated: 2022-08-22T08:07:42Z
day: '19'
doi: 10.1007/978-3-030-55336-4_33
edition: '1'
editor:
- first_name: Mario
full_name: Monteiro, Mario
last_name: Monteiro
- first_name: Rafael A
full_name: Garcia, Rafael A
last_name: Garcia
- first_name: Jorgen
full_name: Christensen-Dalsgaard, Jorgen
last_name: Christensen-Dalsgaard
- first_name: Scott W
full_name: McIntosh, Scott W
last_name: McIntosh
extern: '1'
external_id:
arxiv:
- '2012.08684'
intvolume: ' 57'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2012.08684
month: '12'
oa: 1
oa_version: Preprint
page: 251-257
place: Cham
publication: Dynamics of the Sun and Stars
publication_identifier:
eisbn:
- 978-3-030-55336-4
eissn:
- 1570-6605
isbn:
- 978-3-030-55335-7
issn:
- 1570-6591
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: ASSSP
status: public
title: The impact of a fossil magnetic field on dipolar mixed-mode frequencies in
sub- and red-giant stars
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2020'
...
---
_id: '11675'
abstract:
- lang: eng
text: 'We consider the problems of maintaining an approximate maximum matching and
an approximate minimum vertex cover in a dynamic graph undergoing a sequence of
edge insertions/deletions. Starting with the seminal work of Onak and Rubinfeld
(in: Proceedings of the ACM symposium on theory of computing (STOC), 2010), this
problem has received significant attention in recent years. Very recently, extending
the framework of Baswana et al. (in: Proceedings of the IEEE symposium on foundations
of computer science (FOCS), 2011) , Solomon (in: Proceedings of the IEEE symposium
on foundations of computer science (FOCS), 2016) gave a randomized dynamic algorithm
for this problem that has an approximation ratio of 2 and an amortized update
time of O(1) with high probability. This algorithm requires the assumption of
an oblivious adversary, meaning that the future sequence of edge insertions/deletions
in the graph cannot depend in any way on the algorithm’s past output. A natural
way to remove the assumption on oblivious adversary is to give a deterministic
dynamic algorithm for the same problem in O(1) update time. In this paper, we
resolve this question. We present a new deterministic fully dynamic algorithm
that maintains a O(1)-approximate minimum vertex cover and maximum fractional
matching, with an amortized update time of O(1). Previously, the best deterministic
algorithm for this problem was due to Bhattacharya et al. (in: Proceedings of
the ACM-SIAM symposium on discrete algorithms (SODA), 2015); it had an approximation
ratio of (2+ε) and an amortized update time of O(logn/ε2). Our result can be generalized
to give a fully dynamic O(f3)-approximate algorithm with O(f2) amortized update
time for the hypergraph vertex cover and fractional hypergraph matching problem,
where every hyperedge has at most f vertices.'
article_processing_charge: No
article_type: original
author:
- first_name: Sayan
full_name: Bhattacharya, Sayan
last_name: Bhattacharya
- first_name: Deeparnab
full_name: Chakrabarty, Deeparnab
last_name: Chakrabarty
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Bhattacharya S, Chakrabarty D, Henzinger MH. Deterministic dynamic matching
in O(1) update time. Algorithmica. 2020;82(4):1057-1080. doi:10.1007/s00453-019-00630-4
apa: Bhattacharya, S., Chakrabarty, D., & Henzinger, M. H. (2020). Deterministic
dynamic matching in O(1) update time. Algorithmica. Springer Nature. https://doi.org/10.1007/s00453-019-00630-4
chicago: Bhattacharya, Sayan, Deeparnab Chakrabarty, and Monika H Henzinger. “Deterministic
Dynamic Matching in O(1) Update Time.” Algorithmica. Springer Nature, 2020.
https://doi.org/10.1007/s00453-019-00630-4.
ieee: S. Bhattacharya, D. Chakrabarty, and M. H. Henzinger, “Deterministic dynamic
matching in O(1) update time,” Algorithmica, vol. 82, no. 4. Springer Nature,
pp. 1057–1080, 2020.
ista: Bhattacharya S, Chakrabarty D, Henzinger MH. 2020. Deterministic dynamic matching
in O(1) update time. Algorithmica. 82(4), 1057–1080.
mla: Bhattacharya, Sayan, et al. “Deterministic Dynamic Matching in O(1) Update
Time.” Algorithmica, vol. 82, no. 4, Springer Nature, 2020, pp. 1057–80,
doi:10.1007/s00453-019-00630-4.
short: S. Bhattacharya, D. Chakrabarty, M.H. Henzinger, Algorithmica 82 (2020) 1057–1080.
date_created: 2022-07-27T14:31:06Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2022-09-12T08:55:46Z
day: '01'
doi: 10.1007/s00453-019-00630-4
extern: '1'
intvolume: ' 82'
issue: '4'
keyword:
- Dynamic algorithms
- Data structures
- Graph algorithms
- Matching
- Vertex cover
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1007/s00453-019-00630-4
month: '04'
oa: 1
oa_version: Published Version
page: 1057-1080
publication: Algorithmica
publication_identifier:
eissn:
- 1432-0541
issn:
- 0178-4617
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Deterministic dynamic matching in O(1) update time
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 82
year: '2020'
...
---
_id: '11674'
abstract:
- lang: eng
text: In this paper, we study the problem of opening centers to cluster a set of
clients in a metric space so as to minimize the sum of the costs of the centers
and of the cluster radii, in a dynamic environment where clients arrive and depart,
and the solution must be updated efficiently while remaining competitive with
respect to the current optimal solution. We call this dynamic sum-of-radii clustering
problem. We present a data structure that maintains a solution whose cost is within
a constant factor of the cost of an optimal solution in metric spaces with bounded
doubling dimension and whose worst-case update time is logarithmic in the parameters
of the problem.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Dariusz
full_name: Leniowski, Dariusz
last_name: Leniowski
- first_name: Claire
full_name: Mathieu, Claire
last_name: Mathieu
citation:
ama: Henzinger MH, Leniowski D, Mathieu C. Dynamic clustering to minimize the sum
of radii. Algorithmica. 2020;82(11):3183-3194. doi:10.1007/s00453-020-00721-7
apa: Henzinger, M. H., Leniowski, D., & Mathieu, C. (2020). Dynamic clustering
to minimize the sum of radii. Algorithmica. Springer Nature. https://doi.org/10.1007/s00453-020-00721-7
chicago: Henzinger, Monika H, Dariusz Leniowski, and Claire Mathieu. “Dynamic Clustering
to Minimize the Sum of Radii.” Algorithmica. Springer Nature, 2020. https://doi.org/10.1007/s00453-020-00721-7.
ieee: M. H. Henzinger, D. Leniowski, and C. Mathieu, “Dynamic clustering to minimize
the sum of radii,” Algorithmica, vol. 82, no. 11. Springer Nature, pp.
3183–3194, 2020.
ista: Henzinger MH, Leniowski D, Mathieu C. 2020. Dynamic clustering to minimize
the sum of radii. Algorithmica. 82(11), 3183–3194.
mla: Henzinger, Monika H., et al. “Dynamic Clustering to Minimize the Sum of Radii.”
Algorithmica, vol. 82, no. 11, Springer Nature, 2020, pp. 3183–94, doi:10.1007/s00453-020-00721-7.
short: M.H. Henzinger, D. Leniowski, C. Mathieu, Algorithmica 82 (2020) 3183–3194.
date_created: 2022-07-27T13:58:58Z
date_published: 2020-11-01T00:00:00Z
date_updated: 2022-09-12T08:50:14Z
day: '01'
doi: 10.1007/s00453-020-00721-7
extern: '1'
external_id:
arxiv:
- '1707.02577'
intvolume: ' 82'
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.1707.02577
month: '11'
oa: 1
oa_version: Preprint
page: 3183-3194
publication: Algorithmica
publication_identifier:
eissn:
- 1432-0541
issn:
- 0178-4617
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic clustering to minimize the sum of radii
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 82
year: '2020'
...
---
_id: '11818'
abstract:
- lang: eng
text: "With input sizes becoming massive, coresets - small yet representative summary
of the input - are relevant more than ever. A weighted set C_w that is a subset
of the input is an ε-coreset if the cost of any feasible solution S with respect
to C_w is within [1±ε] of the cost of S with respect to the original input. We
give a very general technique to compute coresets in the fully-dynamic setting
where input points can be added or deleted. Given a static (i.e., not dynamic)
ε-coreset-construction algorithm that runs in time t(n, ε, λ) and computes a coreset
of size s(n, ε, λ), where n is the number of input points and 1-λ is the success
probability, we give a fully-dynamic algorithm that computes an ε-coreset with
worst-case update time O((log n) ⋅ t(s(n, ε/log n, λ/n), ε/log n, λ/n)) (this
bound is stated informally), where the success probability is 1-λ. Our technique
is a fully-dynamic analog of the merge-and-reduce technique, which is due to Har-Peled
and Mazumdar [Har-Peled and Mazumdar, 2004] and is based on a technique of Bentley
and Saxe [Jon Louis Bentley and James B. Saxe, 1980], that applies to the insertion-only
setting where points can only be added. Although, our space usage is O(n), our
technique works in the presence of an adaptive adversary, and we show that Ω(n)
space is required when adversary is adaptive.\r\nAs a concrete implication of
our technique, using the result of Braverman et al. [{Braverman} et al., 2016],
we get fully-dynamic ε-coreset-construction algorithms for k-median and k-means
with worst-case update time O(ε^{-2} k² log⁵ n log³ k) and coreset size O(ε^{-2}
k log n log² k) ignoring log log n and log(1/ε) factors and assuming that ε =
Ω(1/poly(n)) and λ = Ω(1/poly(n)) (which are very weak assumptions made only to
make these bounds easy to parse). This results in the first fully-dynamic constant-approximation
algorithms for k-median and k-means with update times O(poly(k, log n, ε^{-1})).
Specifically, the dependence on k is only quadratic, and the bounds are worst-case.
The best previous bound for both problems was amortized O(nlog n) by Cohen-Addad
et al. [Cohen-Addad et al., 2019] via randomized O(1)-coresets in O(n) space.\r\nWe
also show that under the OMv conjecture [Monika Henzinger et al., 2015], a fully-dynamic
(4 - δ)-approximation algorithm for k-means must either have an amortized update
time of Ω(k^{1-γ}) or amortized query time of Ω(k^{2 - γ}), where γ > 0 is a constant."
alternative_title:
- LIPIcs
article_number: '57'
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Sagar
full_name: Kale, Sagar
last_name: Kale
citation:
ama: 'Henzinger MH, Kale S. Fully-dynamic coresets. In: 28th Annual European
Symposium on Algorithms. Vol 173. Schloss Dagstuhl - Leibniz-Zentrum für Informatik;
2020. doi:10.4230/LIPIcs.ESA.2020.57'
apa: 'Henzinger, M. H., & Kale, S. (2020). Fully-dynamic coresets. In 28th
Annual European Symposium on Algorithms (Vol. 173). Pisa, Italy: Schloss Dagstuhl
- Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.ESA.2020.57'
chicago: Henzinger, Monika H, and Sagar Kale. “Fully-Dynamic Coresets.” In 28th
Annual European Symposium on Algorithms, Vol. 173. Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 2020. https://doi.org/10.4230/LIPIcs.ESA.2020.57.
ieee: M. H. Henzinger and S. Kale, “Fully-dynamic coresets,” in 28th Annual European
Symposium on Algorithms, Pisa, Italy, 2020, vol. 173.
ista: 'Henzinger MH, Kale S. 2020. Fully-dynamic coresets. 28th Annual European
Symposium on Algorithms. ESA: Annual European Symposium on Algorithms, LIPIcs,
vol. 173, 57.'
mla: Henzinger, Monika H., and Sagar Kale. “Fully-Dynamic Coresets.” 28th Annual
European Symposium on Algorithms, vol. 173, 57, Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 2020, doi:10.4230/LIPIcs.ESA.2020.57.
short: M.H. Henzinger, S. Kale, in:, 28th Annual European Symposium on Algorithms,
Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020.
conference:
end_date: 2020-09-09
location: Pisa, Italy
name: 'ESA: Annual European Symposium on Algorithms'
start_date: 2020-09-07
date_created: 2022-08-12T07:22:55Z
date_published: 2020-08-26T00:00:00Z
date_updated: 2023-02-14T09:29:51Z
day: '26'
doi: 10.4230/LIPIcs.ESA.2020.57
extern: '1'
external_id:
arxiv:
- '2004.14891'
intvolume: ' 173'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.4230/LIPIcs.ESA.2020.57
month: '08'
oa: 1
oa_version: Published Version
publication: 28th Annual European Symposium on Algorithms
publication_identifier:
isbn:
- '9783959771627'
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fully-dynamic coresets
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 173
year: '2020'
...
---
_id: '11816'
abstract:
- lang: eng
text: In recent years, significant advances have been made in the design and analysis
of fully dynamic maximal matching algorithms. However, these theoretical results
have received very little attention from the practical perspective. Few of the
algorithms are implemented and tested on real datasets, and their practical potential
is far from understood. In this paper, we attempt to bridge the gap between theory
and practice that is currently observed for the fully dynamic maximal matching
problem. We engineer several algorithms and empirically study those algorithms
on an extensive set of dynamic instances.
alternative_title:
- LIPIcs
article_number: '58'
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Khan
full_name: Shahbaz, Khan
last_name: Shahbaz
- first_name: Richard
full_name: Paul, Richard
last_name: Paul
- first_name: Christian
full_name: Schulz, Christian
last_name: Schulz
citation:
ama: 'Henzinger MH, Shahbaz K, Paul R, Schulz C. Dynamic matching algorithms in
practice. In: 8th Annual European Symposium on Algorithms. Vol 173. Schloss
Dagstuhl - Leibniz-Zentrum für Informatik; 2020. doi:10.4230/LIPIcs.ESA.2020.58'
apa: 'Henzinger, M. H., Shahbaz, K., Paul, R., & Schulz, C. (2020). Dynamic
matching algorithms in practice. In 8th Annual European Symposium on Algorithms
(Vol. 173). Pisa, Italy: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.ESA.2020.58'
chicago: Henzinger, Monika H, Khan Shahbaz, Richard Paul, and Christian Schulz.
“Dynamic Matching Algorithms in Practice.” In 8th Annual European Symposium
on Algorithms, Vol. 173. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2020. https://doi.org/10.4230/LIPIcs.ESA.2020.58.
ieee: M. H. Henzinger, K. Shahbaz, R. Paul, and C. Schulz, “Dynamic matching algorithms
in practice,” in 8th Annual European Symposium on Algorithms, Pisa, Italy,
2020, vol. 173.
ista: 'Henzinger MH, Shahbaz K, Paul R, Schulz C. 2020. Dynamic matching algorithms
in practice. 8th Annual European Symposium on Algorithms. ESA: Annual European
Symposium on Algorithms, LIPIcs, vol. 173, 58.'
mla: Henzinger, Monika H., et al. “Dynamic Matching Algorithms in Practice.” 8th
Annual European Symposium on Algorithms, vol. 173, 58, Schloss Dagstuhl -
Leibniz-Zentrum für Informatik, 2020, doi:10.4230/LIPIcs.ESA.2020.58.
short: M.H. Henzinger, K. Shahbaz, R. Paul, C. Schulz, in:, 8th Annual European
Symposium on Algorithms, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020.
conference:
end_date: 2020-09-09
location: Pisa, Italy
name: 'ESA: Annual European Symposium on Algorithms'
start_date: 2020-09-07
date_created: 2022-08-12T07:13:25Z
date_published: 2020-08-26T00:00:00Z
date_updated: 2023-02-14T08:57:55Z
day: '26'
doi: 10.4230/LIPIcs.ESA.2020.58
extern: '1'
external_id:
arxiv:
- '2004.09099'
intvolume: ' 173'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.4230/LIPIcs.ESA.2020.58
month: '08'
oa: 1
oa_version: Published Version
publication: 8th Annual European Symposium on Algorithms
publication_identifier:
isbn:
- '9783959771627'
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic matching algorithms in practice
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 173
year: '2020'
...
---
_id: '11824'
abstract:
- lang: eng
text: "Independent set is a fundamental problem in combinatorial optimization. While
in general graphs the problem is essentially inapproximable, for many important
graph classes there are approximation algorithms known in the offline setting.
These graph classes include interval graphs and geometric intersection graphs,
where vertices correspond to intervals/geometric objects and an edge indicates
that the two corresponding objects intersect.\r\nWe present dynamic approximation
algorithms for independent set of intervals, hypercubes and hyperrectangles in
d dimensions. They work in the fully dynamic model where each update inserts or
deletes a geometric object. All our algorithms are deterministic and have worst-case
update times that are polylogarithmic for constant d and ε>0, assuming that the
coordinates of all input objects are in [0, N]^d and each of their edges has length
at least 1. We obtain the following results:\r\n- For weighted intervals, we maintain
a (1+ε)-approximate solution.\r\n- For d-dimensional hypercubes we maintain a
(1+ε)2^d-approximate solution in the unweighted case and a O(2^d)-approximate
solution in the weighted case. Also, we show that for maintaining an unweighted
(1+ε)-approximate solution one needs polynomial update time for d ≥ 2 if the ETH
holds.\r\n- For weighted d-dimensional hyperrectangles we present a dynamic algorithm
with approximation ratio (1+ε)log^{d-1}N."
alternative_title:
- LIPIcs
article_number: '51'
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Stefan
full_name: Neumann, Stefan
last_name: Neumann
- first_name: Andreas
full_name: Wiese, Andreas
last_name: Wiese
citation:
ama: 'Henzinger MH, Neumann S, Wiese A. Dynamic approximate maximum independent
set of intervals, hypercubes and hyperrectangles. In: 36th International Symposium
on Computational Geometry. Vol 164. Schloss Dagstuhl - Leibniz-Zentrum für
Informatik; 2020. doi:10.4230/LIPIcs.SoCG.2020.51'
apa: 'Henzinger, M. H., Neumann, S., & Wiese, A. (2020). Dynamic approximate
maximum independent set of intervals, hypercubes and hyperrectangles. In 36th
International Symposium on Computational Geometry (Vol. 164). Zurich, Switzerland:
Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.SoCG.2020.51'
chicago: Henzinger, Monika H, Stefan Neumann, and Andreas Wiese. “Dynamic Approximate
Maximum Independent Set of Intervals, Hypercubes and Hyperrectangles.” In 36th
International Symposium on Computational Geometry, Vol. 164. Schloss Dagstuhl
- Leibniz-Zentrum für Informatik, 2020. https://doi.org/10.4230/LIPIcs.SoCG.2020.51.
ieee: M. H. Henzinger, S. Neumann, and A. Wiese, “Dynamic approximate maximum independent
set of intervals, hypercubes and hyperrectangles,” in 36th International Symposium
on Computational Geometry, Zurich, Switzerland, 2020, vol. 164.
ista: 'Henzinger MH, Neumann S, Wiese A. 2020. Dynamic approximate maximum independent
set of intervals, hypercubes and hyperrectangles. 36th International Symposium
on Computational Geometry. SoCG: Symposium on Computational Geometry, LIPIcs,
vol. 164, 51.'
mla: Henzinger, Monika H., et al. “Dynamic Approximate Maximum Independent Set of
Intervals, Hypercubes and Hyperrectangles.” 36th International Symposium on
Computational Geometry, vol. 164, 51, Schloss Dagstuhl - Leibniz-Zentrum für
Informatik, 2020, doi:10.4230/LIPIcs.SoCG.2020.51.
short: M.H. Henzinger, S. Neumann, A. Wiese, in:, 36th International Symposium on
Computational Geometry, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020.
conference:
end_date: 2020-06-26
location: Zurich, Switzerland
name: 'SoCG: Symposium on Computational Geometry'
start_date: 2020-06-23
date_created: 2022-08-12T07:46:44Z
date_published: 2020-06-08T00:00:00Z
date_updated: 2023-02-14T10:00:58Z
day: '08'
doi: 10.4230/LIPIcs.SoCG.2020.51
extern: '1'
external_id:
arxiv:
- '2003.02605'
intvolume: ' 164'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.4230/LIPIcs.SoCG.2020.51
month: '06'
oa: 1
oa_version: Published Version
publication: 36th International Symposium on Computational Geometry
publication_identifier:
isbn:
- '9783959771436'
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic approximate maximum independent set of intervals, hypercubes and hyperrectangles
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 164
year: '2020'
...