---
OA_place: repository
OA_type: green
_id: '17868'
abstract:
- lang: eng
  text: Reversed conductance decay describes increasing conductance of a molecular
    chain series with increasing chain length. Realizing reversed conductance decay
    is an important step toward making long and highly conducting molecular wires.
    Recent work has shown that one-dimensional topological insulators (1D TIs) can
    exhibit reversed conductance decay due to their nontrivial edge states. The Su–Schrieffer–Heeger
    (SSH) model for 1D TIs relates to the electronic structure of these isolated molecules
    but not their electron transport properties as single-molecule junctions. Herein,
    we use a tight-binding approach to demonstrate that polyacetylene and other diradicaloid
    1D TIs show a reversed conductance decay at the short chain limit. We explain
    these conductance trends by analyzing the impact of the edge states in these 1D
    systems on the single-molecule junction transmission. Additionally, we discuss
    how the self-energy from the electrode-molecule coupling and the on-site energy
    of the edge sites can be tuned to create longer wires with reversed conductance
    decays.
article_processing_charge: No
article_type: original
author:
- first_name: Liang
  full_name: Li, Liang
  last_name: Li
- first_name: Suman
  full_name: Gunasekaran, Suman
  last_name: Gunasekaran
- first_name: Yujing
  full_name: Wei, Yujing
  last_name: Wei
- first_name: Colin
  full_name: Nuckolls, Colin
  last_name: Nuckolls
- first_name: Latha
  full_name: Venkataraman, Latha
  id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
  last_name: Venkataraman
  orcid: 0000-0002-6957-6089
citation:
  ama: Li L, Gunasekaran S, Wei Y, Nuckolls C, Venkataraman L. Reversed conductance
    decay of 1D topological insulators by tight-binding analysis. <i>The Journal of
    Physical Chemistry Letters</i>. 2022;13(41):9703-9710. doi:<a href="https://doi.org/10.1021/acs.jpclett.2c02812">10.1021/acs.jpclett.2c02812</a>
  apa: Li, L., Gunasekaran, S., Wei, Y., Nuckolls, C., &#38; Venkataraman, L. (2022).
    Reversed conductance decay of 1D topological insulators by tight-binding analysis.
    <i>The Journal of Physical Chemistry Letters</i>. American Chemical Society. <a
    href="https://doi.org/10.1021/acs.jpclett.2c02812">https://doi.org/10.1021/acs.jpclett.2c02812</a>
  chicago: Li, Liang, Suman Gunasekaran, Yujing Wei, Colin Nuckolls, and Latha Venkataraman.
    “Reversed Conductance Decay of 1D Topological Insulators by Tight-Binding Analysis.”
    <i>The Journal of Physical Chemistry Letters</i>. American Chemical Society, 2022.
    <a href="https://doi.org/10.1021/acs.jpclett.2c02812">https://doi.org/10.1021/acs.jpclett.2c02812</a>.
  ieee: L. Li, S. Gunasekaran, Y. Wei, C. Nuckolls, and L. Venkataraman, “Reversed
    conductance decay of 1D topological insulators by tight-binding analysis,” <i>The
    Journal of Physical Chemistry Letters</i>, vol. 13, no. 41. American Chemical
    Society, pp. 9703–9710, 2022.
  ista: Li L, Gunasekaran S, Wei Y, Nuckolls C, Venkataraman L. 2022. Reversed conductance
    decay of 1D topological insulators by tight-binding analysis. The Journal of Physical
    Chemistry Letters. 13(41), 9703–9710.
  mla: Li, Liang, et al. “Reversed Conductance Decay of 1D Topological Insulators
    by Tight-Binding Analysis.” <i>The Journal of Physical Chemistry Letters</i>,
    vol. 13, no. 41, American Chemical Society, 2022, pp. 9703–10, doi:<a href="https://doi.org/10.1021/acs.jpclett.2c02812">10.1021/acs.jpclett.2c02812</a>.
  short: L. Li, S. Gunasekaran, Y. Wei, C. Nuckolls, L. Venkataraman, The Journal
    of Physical Chemistry Letters 13 (2022) 9703–9710.
date_created: 2024-09-06T13:02:46Z
date_published: 2022-10-11T00:00:00Z
date_updated: 2024-12-10T09:21:49Z
day: '11'
doi: 10.1021/acs.jpclett.2c02812
extern: '1'
external_id:
  pmid:
  - '36219846'
intvolume: '        13'
issue: '41'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.26434/chemrxiv-2022-b1fh9-v3
month: '10'
oa: 1
oa_version: Preprint
page: 9703-9710
pmid: 1
publication: The Journal of Physical Chemistry Letters
publication_identifier:
  issn:
  - 1948-7185
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reversed conductance decay of 1D topological insulators by tight-binding analysis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2022'
...
---
OA_place: repository
OA_type: green
_id: '17869'
abstract:
- lang: eng
  text: The formation of carbon–carbon bonds with transition metal reagents serves
    as a cornerstone of organic synthesis. Here, we show that the reactivity of an
    otherwise kinetically inert transition metal complex can be induced by an external
    electric field to affect a coupling reaction. These results highlight the importance
    of electric field effects in reaction chemistry and offers a new strategy to modulate
    organometallic reactivity.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Nicholas M.
  full_name: Orchanian, Nicholas M.
  last_name: Orchanian
- first_name: Sophia
  full_name: Guizzo, Sophia
  last_name: Guizzo
- first_name: Michael L.
  full_name: Steigerwald, Michael L.
  last_name: Steigerwald
- first_name: Colin
  full_name: Nuckolls, Colin
  last_name: Nuckolls
- first_name: Latha
  full_name: Venkataraman, Latha
  id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
  last_name: Venkataraman
  orcid: 0000-0002-6957-6089
citation:
  ama: Orchanian NM, Guizzo S, Steigerwald ML, Nuckolls C, Venkataraman L. Electric-field-induced
    coupling of aryl iodides with a nickel(0) complex. <i>Chemical Communications</i>.
    2022;58(90):12556-12559. doi:<a href="https://doi.org/10.1039/d2cc03671a">10.1039/d2cc03671a</a>
  apa: Orchanian, N. M., Guizzo, S., Steigerwald, M. L., Nuckolls, C., &#38; Venkataraman,
    L. (2022). Electric-field-induced coupling of aryl iodides with a nickel(0) complex.
    <i>Chemical Communications</i>. Royal Society of Chemistry. <a href="https://doi.org/10.1039/d2cc03671a">https://doi.org/10.1039/d2cc03671a</a>
  chicago: Orchanian, Nicholas M., Sophia Guizzo, Michael L. Steigerwald, Colin Nuckolls,
    and Latha Venkataraman. “Electric-Field-Induced Coupling of Aryl Iodides with
    a Nickel(0) Complex.” <i>Chemical Communications</i>. Royal Society of Chemistry,
    2022. <a href="https://doi.org/10.1039/d2cc03671a">https://doi.org/10.1039/d2cc03671a</a>.
  ieee: N. M. Orchanian, S. Guizzo, M. L. Steigerwald, C. Nuckolls, and L. Venkataraman,
    “Electric-field-induced coupling of aryl iodides with a nickel(0) complex,” <i>Chemical
    Communications</i>, vol. 58, no. 90. Royal Society of Chemistry, pp. 12556–12559,
    2022.
  ista: Orchanian NM, Guizzo S, Steigerwald ML, Nuckolls C, Venkataraman L. 2022.
    Electric-field-induced coupling of aryl iodides with a nickel(0) complex. Chemical
    Communications. 58(90), 12556–12559.
  mla: Orchanian, Nicholas M., et al. “Electric-Field-Induced Coupling of Aryl Iodides
    with a Nickel(0) Complex.” <i>Chemical Communications</i>, vol. 58, no. 90, Royal
    Society of Chemistry, 2022, pp. 12556–59, doi:<a href="https://doi.org/10.1039/d2cc03671a">10.1039/d2cc03671a</a>.
  short: N.M. Orchanian, S. Guizzo, M.L. Steigerwald, C. Nuckolls, L. Venkataraman,
    Chemical Communications 58 (2022) 12556–12559.
date_created: 2024-09-06T13:03:38Z
date_published: 2022-10-10T00:00:00Z
date_updated: 2024-12-10T09:27:04Z
day: '10'
doi: 10.1039/d2cc03671a
extern: '1'
external_id:
  pmid:
  - '36245392'
intvolume: '        58'
issue: '90'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.26434/chemrxiv-2022-lfnw1
month: '10'
oa: 1
oa_version: Preprint
page: 12556-12559
pmid: 1
publication: Chemical Communications
publication_identifier:
  eissn:
  - 1364-548X
  issn:
  - 1359-7345
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1039/d2cc03671a
scopus_import: '1'
status: public
title: Electric-field-induced coupling of aryl iodides with a nickel(0) complex
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 58
year: '2022'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '17870'
abstract:
- lang: eng
  text: The electric fields created at solid–liquid interfaces are important in heterogeneous
    catalysis. Here we describe the Ullmann coupling of aryl iodides on rough gold
    surfaces, which we monitor in situ using the scanning tunneling microscope-based
    break junction (STM-BJ) and ex situ using mass spectrometry and fluorescence spectroscopy.
    We find that this Ullmann coupling reaction occurs only on rough gold surfaces
    in polar solvents, the latter of which implicates interfacial electric fields.
    These experimental observations are supported by density functional theory calculations
    that elucidate the roles of surface roughness and local electric fields on the
    reaction. More broadly, this touchstone study offers a facile method to access
    and probe in real time an increasingly prominent yet incompletely understood mode
    of catalysis.
article_processing_charge: Yes
article_type: original
author:
- first_name: Ilana B.
  full_name: Stone, Ilana B.
  last_name: Stone
- first_name: Rachel L.
  full_name: Starr, Rachel L.
  last_name: Starr
- first_name: Norah
  full_name: Hoffmann, Norah
  last_name: Hoffmann
- first_name: Xiao
  full_name: Wang, Xiao
  last_name: Wang
- first_name: Austin M.
  full_name: Evans, Austin M.
  last_name: Evans
- first_name: Colin
  full_name: Nuckolls, Colin
  last_name: Nuckolls
- first_name: Tristan H.
  full_name: Lambert, Tristan H.
  last_name: Lambert
- first_name: Michael L.
  full_name: Steigerwald, Michael L.
  last_name: Steigerwald
- first_name: Timothy C.
  full_name: Berkelbach, Timothy C.
  last_name: Berkelbach
- first_name: Xavier
  full_name: Roy, Xavier
  last_name: Roy
- first_name: Latha
  full_name: Venkataraman, Latha
  id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
  last_name: Venkataraman
  orcid: 0000-0002-6957-6089
citation:
  ama: Stone IB, Starr RL, Hoffmann N, et al. Interfacial electric fields catalyze
    Ullmann coupling reactions on gold surfaces. <i>Chemical Science</i>. 2022;13(36):10798-10805.
    doi:<a href="https://doi.org/10.1039/d2sc03780g">10.1039/d2sc03780g</a>
  apa: Stone, I. B., Starr, R. L., Hoffmann, N., Wang, X., Evans, A. M., Nuckolls,
    C., … Venkataraman, L. (2022). Interfacial electric fields catalyze Ullmann coupling
    reactions on gold surfaces. <i>Chemical Science</i>. Royal Society of Chemistry.
    <a href="https://doi.org/10.1039/d2sc03780g">https://doi.org/10.1039/d2sc03780g</a>
  chicago: Stone, Ilana B., Rachel L. Starr, Norah Hoffmann, Xiao Wang, Austin M.
    Evans, Colin Nuckolls, Tristan H. Lambert, et al. “Interfacial Electric Fields
    Catalyze Ullmann Coupling Reactions on Gold Surfaces.” <i>Chemical Science</i>.
    Royal Society of Chemistry, 2022. <a href="https://doi.org/10.1039/d2sc03780g">https://doi.org/10.1039/d2sc03780g</a>.
  ieee: I. B. Stone <i>et al.</i>, “Interfacial electric fields catalyze Ullmann coupling
    reactions on gold surfaces,” <i>Chemical Science</i>, vol. 13, no. 36. Royal Society
    of Chemistry, pp. 10798–10805, 2022.
  ista: Stone IB, Starr RL, Hoffmann N, Wang X, Evans AM, Nuckolls C, Lambert TH,
    Steigerwald ML, Berkelbach TC, Roy X, Venkataraman L. 2022. Interfacial electric
    fields catalyze Ullmann coupling reactions on gold surfaces. Chemical Science.
    13(36), 10798–10805.
  mla: Stone, Ilana B., et al. “Interfacial Electric Fields Catalyze Ullmann Coupling
    Reactions on Gold Surfaces.” <i>Chemical Science</i>, vol. 13, no. 36, Royal Society
    of Chemistry, 2022, pp. 10798–805, doi:<a href="https://doi.org/10.1039/d2sc03780g">10.1039/d2sc03780g</a>.
  short: I.B. Stone, R.L. Starr, N. Hoffmann, X. Wang, A.M. Evans, C. Nuckolls, T.H.
    Lambert, M.L. Steigerwald, T.C. Berkelbach, X. Roy, L. Venkataraman, Chemical
    Science 13 (2022) 10798–10805.
date_created: 2024-09-06T13:04:27Z
date_published: 2022-09-01T00:00:00Z
date_updated: 2024-12-10T09:29:53Z
day: '01'
doi: 10.1039/d2sc03780g
extern: '1'
intvolume: '        13'
issue: '36'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/3.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1039/D2SC03780G
month: '09'
oa: 1
oa_version: Published Version
page: 10798-10805
publication: Chemical Science
publication_identifier:
  eissn:
  - 2041-6539
  issn:
  - 2041-6520
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interfacial electric fields catalyze Ullmann coupling reactions on gold surfaces
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/3.0/legalcode
  name: Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
  short: CC BY-NC (3.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2022'
...
---
OA_place: repository
OA_type: green
_id: '17873'
abstract:
- lang: eng
  text: <jats:title>Abstract</jats:title><jats:p>A critical overview of the theory
    of the chirality‐induced spin selectivity (CISS) effect, that is, phenomena in
    which the chirality of molecular species imparts significant spin selectivity
    to various electron processes, is provided. Based on discussions in a recently
    held workshop, and further work published since, the status of CISS effects—in
    electron transmission, electron transport, and chemical reactions—is reviewed.
    For each, a detailed discussion of the state‐of‐the‐art in theoretical understanding
    is provided and remaining challenges and research opportunities are identified.</jats:p>
article_number: '2106629'
article_processing_charge: No
article_type: review
arxiv: 1
author:
- first_name: Ferdinand
  full_name: Evers, Ferdinand
  last_name: Evers
- first_name: Amnon
  full_name: Aharony, Amnon
  last_name: Aharony
- first_name: Nir
  full_name: Bar‐Gill, Nir
  last_name: Bar‐Gill
- first_name: Ora
  full_name: Entin‐Wohlman, Ora
  last_name: Entin‐Wohlman
- first_name: Per
  full_name: Hedegård, Per
  last_name: Hedegård
- first_name: Oded
  full_name: Hod, Oded
  last_name: Hod
- first_name: Pavel
  full_name: Jelinek, Pavel
  last_name: Jelinek
- first_name: Grzegorz
  full_name: Kamieniarz, Grzegorz
  last_name: Kamieniarz
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  last_name: Lemeshko
- first_name: Karen
  full_name: Michaeli, Karen
  last_name: Michaeli
- first_name: Vladimiro
  full_name: Mujica, Vladimiro
  last_name: Mujica
- first_name: Ron
  full_name: Naaman, Ron
  last_name: Naaman
- first_name: Yossi
  full_name: Paltiel, Yossi
  last_name: Paltiel
- first_name: Sivan
  full_name: Refaely‐Abramson, Sivan
  last_name: Refaely‐Abramson
- first_name: Oren
  full_name: Tal, Oren
  last_name: Tal
- first_name: Jos
  full_name: Thijssen, Jos
  last_name: Thijssen
- first_name: Michael
  full_name: Thoss, Michael
  last_name: Thoss
- first_name: Jan M.
  full_name: van Ruitenbeek, Jan M.
  last_name: van Ruitenbeek
- first_name: Latha
  full_name: Venkataraman, Latha
  id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
  last_name: Venkataraman
  orcid: 0000-0002-6957-6089
- first_name: David H.
  full_name: Waldeck, David H.
  last_name: Waldeck
- first_name: Binghai
  full_name: Yan, Binghai
  last_name: Yan
- first_name: Leeor
  full_name: Kronik, Leeor
  last_name: Kronik
citation:
  ama: 'Evers F, Aharony A, Bar‐Gill N, et al. Theory of chirality induced spin selectivity:
    Progress and challenges. <i>Advanced Materials</i>. 2022;34(13). doi:<a href="https://doi.org/10.1002/adma.202106629">10.1002/adma.202106629</a>'
  apa: 'Evers, F., Aharony, A., Bar‐Gill, N., Entin‐Wohlman, O., Hedegård, P., Hod,
    O., … Kronik, L. (2022). Theory of chirality induced spin selectivity: Progress
    and challenges. <i>Advanced Materials</i>. Wiley. <a href="https://doi.org/10.1002/adma.202106629">https://doi.org/10.1002/adma.202106629</a>'
  chicago: 'Evers, Ferdinand, Amnon Aharony, Nir Bar‐Gill, Ora Entin‐Wohlman, Per
    Hedegård, Oded Hod, Pavel Jelinek, et al. “Theory of Chirality Induced Spin Selectivity:
    Progress and Challenges.” <i>Advanced Materials</i>. Wiley, 2022. <a href="https://doi.org/10.1002/adma.202106629">https://doi.org/10.1002/adma.202106629</a>.'
  ieee: 'F. Evers <i>et al.</i>, “Theory of chirality induced spin selectivity: Progress
    and challenges,” <i>Advanced Materials</i>, vol. 34, no. 13. Wiley, 2022.'
  ista: 'Evers F, Aharony A, Bar‐Gill N, Entin‐Wohlman O, Hedegård P, Hod O, Jelinek
    P, Kamieniarz G, Lemeshko M, Michaeli K, Mujica V, Naaman R, Paltiel Y, Refaely‐Abramson
    S, Tal O, Thijssen J, Thoss M, van Ruitenbeek JM, Venkataraman L, Waldeck DH,
    Yan B, Kronik L. 2022. Theory of chirality induced spin selectivity: Progress
    and challenges. Advanced Materials. 34(13), 2106629.'
  mla: 'Evers, Ferdinand, et al. “Theory of Chirality Induced Spin Selectivity: Progress
    and Challenges.” <i>Advanced Materials</i>, vol. 34, no. 13, 2106629, Wiley, 2022,
    doi:<a href="https://doi.org/10.1002/adma.202106629">10.1002/adma.202106629</a>.'
  short: F. Evers, A. Aharony, N. Bar‐Gill, O. Entin‐Wohlman, P. Hedegård, O. Hod,
    P. Jelinek, G. Kamieniarz, M. Lemeshko, K. Michaeli, V. Mujica, R. Naaman, Y.
    Paltiel, S. Refaely‐Abramson, O. Tal, J. Thijssen, M. Thoss, J.M. van Ruitenbeek,
    L. Venkataraman, D.H. Waldeck, B. Yan, L. Kronik, Advanced Materials 34 (2022).
date_created: 2024-09-06T13:07:43Z
date_published: 2022-04-01T00:00:00Z
date_updated: 2024-12-10T09:43:10Z
day: '01'
doi: 10.1002/adma.202106629
extern: '1'
external_id:
  arxiv:
  - '2108.09998'
  pmid:
  - '35064943'
intvolume: '        34'
issue: '13'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2108.09998
month: '04'
oa: 1
oa_version: Preprint
pmid: 1
publication: Advanced Materials
publication_identifier:
  issn:
  - 0935-9648
  - 1521-4095
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Theory of chirality induced spin selectivity: Progress and challenges'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2022'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '17874'
abstract:
- lang: eng
  text: Redox-active two-dimensional polymers (RA-2DPs) are promising lithium battery
    organic cathode materials due to their regular porosities and high chemical stabilities.
    However, weak electrical conductivities inherent to the non-conjugated molecular
    motifs used thus far limit device performance and the practical relevance of these
    materials. We herein address this problem by developing a modular approach to
    construct π-conjugated RA-2DPs with a new polycyclic aromatic redox-active building
    block PDI-DA. Efficient imine-condensation between PDI-DA and two polyfunctional
    amine nodes followed by quantitative alkyl chain removal produced RA-2DPs TAPPy-PDI
    and TAPB-PDI as conjugated, porous, polycrystalline networks. In-plane conjugation
    and permanent porosity endow these materials with high electrical conductivity
    and high ion diffusion rates. As such, both RA-2DPs function as organic cathode
    materials with good rate performance and excellent cycling stability. Importantly,
    the improved design enables higher areal mass-loadings than were previously available,
    which drives a practical demonstration of TAPPy-PDI as the power source for a
    series of LED lights. Collectively, this investigation discloses viable synthetic
    methodologies and design principles for the realization of high-performance organic
    cathode materials.
article_processing_charge: Yes
article_type: original
author:
- first_name: Zexin
  full_name: Jin, Zexin
  last_name: Jin
- first_name: Qian
  full_name: Cheng, Qian
  last_name: Cheng
- first_name: Austin M.
  full_name: Evans, Austin M.
  last_name: Evans
- first_name: Jesse
  full_name: Gray, Jesse
  last_name: Gray
- first_name: Ruiwen
  full_name: Zhang, Ruiwen
  last_name: Zhang
- first_name: Si Tong
  full_name: Bao, Si Tong
  last_name: Bao
- first_name: Fengkai
  full_name: Wei, Fengkai
  last_name: Wei
- first_name: Latha
  full_name: Venkataraman, Latha
  id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
  last_name: Venkataraman
  orcid: 0000-0002-6957-6089
- first_name: Yuan
  full_name: Yang, Yuan
  last_name: Yang
- first_name: Colin
  full_name: Nuckolls, Colin
  last_name: Nuckolls
citation:
  ama: Jin Z, Cheng Q, Evans AM, et al. π-Conjugated redox-active two-dimensional
    polymers as organic cathode materials. <i>Chemical Science</i>. 2022;13(12):3533-3538.
    doi:<a href="https://doi.org/10.1039/d1sc07157b">10.1039/d1sc07157b</a>
  apa: Jin, Z., Cheng, Q., Evans, A. M., Gray, J., Zhang, R., Bao, S. T., … Nuckolls,
    C. (2022). π-Conjugated redox-active two-dimensional polymers as organic cathode
    materials. <i>Chemical Science</i>. Royal Society of Chemistry. <a href="https://doi.org/10.1039/d1sc07157b">https://doi.org/10.1039/d1sc07157b</a>
  chicago: Jin, Zexin, Qian Cheng, Austin M. Evans, Jesse Gray, Ruiwen Zhang, Si Tong
    Bao, Fengkai Wei, Latha Venkataraman, Yuan Yang, and Colin Nuckolls. “π-Conjugated
    Redox-Active Two-Dimensional Polymers as Organic Cathode Materials.” <i>Chemical
    Science</i>. Royal Society of Chemistry, 2022. <a href="https://doi.org/10.1039/d1sc07157b">https://doi.org/10.1039/d1sc07157b</a>.
  ieee: Z. Jin <i>et al.</i>, “π-Conjugated redox-active two-dimensional polymers
    as organic cathode materials,” <i>Chemical Science</i>, vol. 13, no. 12. Royal
    Society of Chemistry, pp. 3533–3538, 2022.
  ista: Jin Z, Cheng Q, Evans AM, Gray J, Zhang R, Bao ST, Wei F, Venkataraman L,
    Yang Y, Nuckolls C. 2022. π-Conjugated redox-active two-dimensional polymers as
    organic cathode materials. Chemical Science. 13(12), 3533–3538.
  mla: Jin, Zexin, et al. “π-Conjugated Redox-Active Two-Dimensional Polymers as Organic
    Cathode Materials.” <i>Chemical Science</i>, vol. 13, no. 12, Royal Society of
    Chemistry, 2022, pp. 3533–38, doi:<a href="https://doi.org/10.1039/d1sc07157b">10.1039/d1sc07157b</a>.
  short: Z. Jin, Q. Cheng, A.M. Evans, J. Gray, R. Zhang, S.T. Bao, F. Wei, L. Venkataraman,
    Y. Yang, C. Nuckolls, Chemical Science 13 (2022) 3533–3538.
date_created: 2024-09-06T13:08:38Z
date_published: 2022-03-08T00:00:00Z
date_updated: 2024-12-10T09:54:17Z
day: '08'
doi: 10.1039/d1sc07157b
extern: '1'
intvolume: '        13'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1039/D1SC07157B
month: '03'
oa: 1
oa_version: Published Version
page: 3533-3538
publication: Chemical Science
publication_identifier:
  eissn:
  - 2041-6539
  issn:
  - 2041-6520
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: π-Conjugated redox-active two-dimensional polymers as organic cathode materials
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/3.0/legalcode
  name: Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
  short: CC BY-NC (3.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2022'
...
---
_id: '18191'
abstract:
- lang: eng
  text: 'Large-scale quantum devices provide insights beyond the reach of classical
    simulations. However, for a reliable and verifiable quantum simulation, the building
    blocks of the quantum device require exquisite benchmarking. This benchmarking
    of large-scale dynamical quantum systems represents a major challenge due to lack
    of efficient tools for their simulation. Here, we present a scalable algorithm
    based on neural networks for Hamiltonian tomography in out-of-equilibrium quantum
    systems. We illustrate our approach using a model for a forefront quantum simulation
    platform: ultracold atoms in optical lattices. Specifically, we show that our
    algorithm is able to reconstruct the Hamiltonian of an arbitrary sized bosonic
    ladder system using an accessible amount of experimental measurements. We are
    able to significantly increase the previously known parameter precision.'
article_number: '023302'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Agnes
  full_name: Valenti, Agnes
  last_name: Valenti
- first_name: Guliuxin
  full_name: Jin, Guliuxin
  last_name: Jin
- first_name: Julian
  full_name: Leonard, Julian
  id: b75b3f45-7995-11ef-9bfd-9a9cd02c3577
  last_name: Leonard
- first_name: Sebastian D.
  full_name: Huber, Sebastian D.
  last_name: Huber
- first_name: Eliska
  full_name: Greplova, Eliska
  last_name: Greplova
citation:
  ama: Valenti A, Jin G, Leonard J, Huber SD, Greplova E. Scalable Hamiltonian learning
    for large-scale out-of-equilibrium quantum dynamics. <i>Physical Review A</i>.
    2022;105(2). doi:<a href="https://doi.org/10.1103/physreva.105.023302">10.1103/physreva.105.023302</a>
  apa: Valenti, A., Jin, G., Leonard, J., Huber, S. D., &#38; Greplova, E. (2022).
    Scalable Hamiltonian learning for large-scale out-of-equilibrium quantum dynamics.
    <i>Physical Review A</i>. American Physical Society. <a href="https://doi.org/10.1103/physreva.105.023302">https://doi.org/10.1103/physreva.105.023302</a>
  chicago: Valenti, Agnes, Guliuxin Jin, Julian Leonard, Sebastian D. Huber, and Eliska
    Greplova. “Scalable Hamiltonian Learning for Large-Scale out-of-Equilibrium Quantum
    Dynamics.” <i>Physical Review A</i>. American Physical Society, 2022. <a href="https://doi.org/10.1103/physreva.105.023302">https://doi.org/10.1103/physreva.105.023302</a>.
  ieee: A. Valenti, G. Jin, J. Leonard, S. D. Huber, and E. Greplova, “Scalable Hamiltonian
    learning for large-scale out-of-equilibrium quantum dynamics,” <i>Physical Review
    A</i>, vol. 105, no. 2. American Physical Society, 2022.
  ista: Valenti A, Jin G, Leonard J, Huber SD, Greplova E. 2022. Scalable Hamiltonian
    learning for large-scale out-of-equilibrium quantum dynamics. Physical Review
    A. 105(2), 023302.
  mla: Valenti, Agnes, et al. “Scalable Hamiltonian Learning for Large-Scale out-of-Equilibrium
    Quantum Dynamics.” <i>Physical Review A</i>, vol. 105, no. 2, 023302, American
    Physical Society, 2022, doi:<a href="https://doi.org/10.1103/physreva.105.023302">10.1103/physreva.105.023302</a>.
  short: A. Valenti, G. Jin, J. Leonard, S.D. Huber, E. Greplova, Physical Review
    A 105 (2022).
date_created: 2024-10-07T11:46:53Z
date_published: 2022-02-01T00:00:00Z
date_updated: 2024-10-08T10:00:23Z
day: '01'
doi: 10.1103/physreva.105.023302
extern: '1'
external_id:
  arxiv:
  - '2103.01240'
intvolume: '       105'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2103.01240
month: '02'
oa: 1
oa_version: Preprint
publication: Physical Review A
publication_identifier:
  eissn:
  - 2469-9934
  issn:
  - 2469-9926
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scalable Hamiltonian learning for large-scale out-of-equilibrium quantum dynamics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 105
year: '2022'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18220'
abstract:
- lang: eng
  text: Synonymous codons translate into the same amino acid. Although the identity
    of synonymous codons is often considered inconsequential to the final protein
    structure, there is mounting evidence for an association between the two. Our
    study examined this association using regression and classification models, finding
    that codon sequences predict protein backbone dihedral angles with a lower error
    than amino acid sequences, and that models trained with true dihedral angles have
    better classification of synonymous codons given structural information than models
    trained with random dihedral angles. Using this classification approach, we investigated
    local codon–codon dependencies and tested whether synonymous codon identity can
    be predicted more accurately from codon context than amino acid context alone,
    and most specifically which codon context position carries the most predictive
    power.
article_number: '21968'
article_processing_charge: Yes
article_type: original
author:
- first_name: Linor
  full_name: Ackerman-Schraier, Linor
  last_name: Ackerman-Schraier
- first_name: Aviv A.
  full_name: Rosenberg, Aviv A.
  last_name: Rosenberg
- first_name: Ailie
  full_name: Marx, Ailie
  last_name: Marx
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
citation:
  ama: Ackerman-Schraier L, Rosenberg AA, Marx A, Bronstein AM. Machine learning approaches
    demonstrate that protein structures carry information about their genetic coding.
    <i>Scientific Reports</i>. 2022;12. doi:<a href="https://doi.org/10.1038/s41598-022-25874-z">10.1038/s41598-022-25874-z</a>
  apa: Ackerman-Schraier, L., Rosenberg, A. A., Marx, A., &#38; Bronstein, A. M. (2022).
    Machine learning approaches demonstrate that protein structures carry information
    about their genetic coding. <i>Scientific Reports</i>. Springer Nature. <a href="https://doi.org/10.1038/s41598-022-25874-z">https://doi.org/10.1038/s41598-022-25874-z</a>
  chicago: Ackerman-Schraier, Linor, Aviv A. Rosenberg, Ailie Marx, and Alex M. Bronstein.
    “Machine Learning Approaches Demonstrate That Protein Structures Carry Information
    about Their Genetic Coding.” <i>Scientific Reports</i>. Springer Nature, 2022.
    <a href="https://doi.org/10.1038/s41598-022-25874-z">https://doi.org/10.1038/s41598-022-25874-z</a>.
  ieee: L. Ackerman-Schraier, A. A. Rosenberg, A. Marx, and A. M. Bronstein, “Machine
    learning approaches demonstrate that protein structures carry information about
    their genetic coding,” <i>Scientific Reports</i>, vol. 12. Springer Nature, 2022.
  ista: Ackerman-Schraier L, Rosenberg AA, Marx A, Bronstein AM. 2022. Machine learning
    approaches demonstrate that protein structures carry information about their genetic
    coding. Scientific Reports. 12, 21968.
  mla: Ackerman-Schraier, Linor, et al. “Machine Learning Approaches Demonstrate That
    Protein Structures Carry Information about Their Genetic Coding.” <i>Scientific
    Reports</i>, vol. 12, 21968, Springer Nature, 2022, doi:<a href="https://doi.org/10.1038/s41598-022-25874-z">10.1038/s41598-022-25874-z</a>.
  short: L. Ackerman-Schraier, A.A. Rosenberg, A. Marx, A.M. Bronstein, Scientific
    Reports 12 (2022).
date_created: 2024-10-08T12:52:29Z
date_published: 2022-12-20T00:00:00Z
date_updated: 2024-10-14T09:46:06Z
day: '20'
doi: 10.1038/s41598-022-25874-z
extern: '1'
external_id:
  pmid:
  - '36539476'
intvolume: '        12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41598-022-25874-z
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific Reports
publication_identifier:
  issn:
  - 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Machine learning approaches demonstrate that protein structures carry information
  about their genetic coding
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2022'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18221'
abstract:
- lang: eng
  text: Synonymous codons translate into chemically identical amino acids. Once considered
    inconsequential to the formation of the protein product, there is evidence to
    suggest that codon usage affects co-translational protein folding and the final
    structure of the expressed protein. Here we develop a method for computing and
    comparing codon-specific Ramachandran plots and demonstrate that the backbone
    dihedral angle distributions of some synonymous codons are distinguishable with
    statistical significance for some secondary structures. This shows that there
    exists a dependence between codon identity and backbone torsion of the translated
    amino acid. Although these findings cannot pinpoint the causal direction of this
    dependence, we discuss the vast biological implications should coding be shown
    to directly shape protein conformation and demonstrate the usefulness of this
    method as a tool for probing associations between codon usage and protein structure.
    Finally, we urge for the inclusion of exact genetic information into structural
    databases.
article_number: '2815'
article_processing_charge: Yes
article_type: original
author:
- first_name: Aviv A.
  full_name: Rosenberg, Aviv A.
  last_name: Rosenberg
- first_name: Ailie
  full_name: Marx, Ailie
  last_name: Marx
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
citation:
  ama: Rosenberg AA, Marx A, Bronstein AM. Codon-specific Ramachandran plots show
    amino acid backbone conformation depends on identity of the translated codon.
    <i>Nature Communications</i>. 2022;13. doi:<a href="https://doi.org/10.1038/s41467-022-30390-9">10.1038/s41467-022-30390-9</a>
  apa: Rosenberg, A. A., Marx, A., &#38; Bronstein, A. M. (2022). Codon-specific Ramachandran
    plots show amino acid backbone conformation depends on identity of the translated
    codon. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-022-30390-9">https://doi.org/10.1038/s41467-022-30390-9</a>
  chicago: Rosenberg, Aviv A., Ailie Marx, and Alex M. Bronstein. “Codon-Specific
    Ramachandran Plots Show Amino Acid Backbone Conformation Depends on Identity of
    the Translated Codon.” <i>Nature Communications</i>. Springer Nature, 2022. <a
    href="https://doi.org/10.1038/s41467-022-30390-9">https://doi.org/10.1038/s41467-022-30390-9</a>.
  ieee: A. A. Rosenberg, A. Marx, and A. M. Bronstein, “Codon-specific Ramachandran
    plots show amino acid backbone conformation depends on identity of the translated
    codon,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.
  ista: Rosenberg AA, Marx A, Bronstein AM. 2022. Codon-specific Ramachandran plots
    show amino acid backbone conformation depends on identity of the translated codon.
    Nature Communications. 13, 2815.
  mla: Rosenberg, Aviv A., et al. “Codon-Specific Ramachandran Plots Show Amino Acid
    Backbone Conformation Depends on Identity of the Translated Codon.” <i>Nature
    Communications</i>, vol. 13, 2815, Springer Nature, 2022, doi:<a href="https://doi.org/10.1038/s41467-022-30390-9">10.1038/s41467-022-30390-9</a>.
  short: A.A. Rosenberg, A. Marx, A.M. Bronstein, Nature Communications 13 (2022).
date_created: 2024-10-08T12:53:01Z
date_published: 2022-05-20T00:00:00Z
date_updated: 2024-10-14T09:49:02Z
day: '20'
doi: 10.1038/s41467-022-30390-9
extern: '1'
external_id:
  pmid:
  - '35595777'
intvolume: '        13'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41467-022-30390-9
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  issn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Codon-specific Ramachandran plots show amino acid backbone conformation depends
  on identity of the translated codon
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2022'
...
---
OA_place: publisher
OA_type: free access
_id: '18222'
abstract:
- lang: eng
  text: "STUDY QUESTION: What is the accuracy and agreement of embryologists when
    assessing the implantation probability of blastocysts using time-lapse imaging
    (TLI), and can it be improved with a data-driven algorithm?\r\n\r\nSUMMARY ANSWER:
    The overall interobserver agreement of a large panel of embryologists was moderate
    and prediction accuracy was modest, while the purpose-built artificial intelligence
    model generally resulted in higher performance metrics.\r\n\r\nWHAT IS KNOWN ALREADY:
    Previous studies have demonstrated significant interobserver variability amongst
    embryologists when assessing embryo quality. However, data concerning embryologists’
    ability to predict implantation probability using TLI is still lacking. Emerging
    technologies based on data-driven tools have shown great promise for improving
    embryo selection and predicting clinical outcomes.\r\n\r\nSTUDY DESIGN, SIZE,
    DURATION: TLI video files of 136 embryos with known implantation data were retrospectively
    collected from two clinical sites between 2018 and 2019 for the performance assessment
    of 36 embryologists and comparison with a deep neural network (DNN).\r\n\r\nPARTICIPANTS/MATERIALS,
    SETTING, METHODS: We recruited 39 embryologists from 13 different countries. All
    participants were blinded to clinical outcomes. A total of 136 TLI videos of embryos
    that reached the blastocyst stage were used for this experiment. Each embryo’s
    likelihood of successfully implanting was assessed by 36 embryologists, providing
    implantation probability grades (IPGs) from 1 to 5, where 1 indicates a very low
    likelihood of implantation and 5 indicates a very high likelihood. Subsequently,
    three embryologists with over 5 years of experience provided Gardner scores. All
    136 blastocysts were categorized into three quality groups based on their Gardner
    scores. Embryologist predictions were then converted into predictions of implantation
    (IPG ≥ 3) and no implantation (IPG ≤ 2). Embryologists’ performance and agreement
    were assessed using Fleiss kappa coefficient. A 10-fold cross-validation DNN was
    developed to provide IPGs for TLI video files. The model’s performance was compared
    to that of the embryologists.\r\n\r\nMAIN RESULTS AND THE ROLE OF CHANCE: Logistic
    regression was employed for the following confounding variables: country of residence,
    academic level, embryo scoring system, log years of experience and experience
    using TLI. None were found to have a statistically significant impact on embryologist
    performance at α = 0.05. The average implantation prediction accuracy for the
    embryologists was 51.9% for all embryos (N = 136). The average accuracy of the
    embryologists when assessing top quality and poor quality embryos (according to
    the Gardner score categorizations) was 57.5% and 57.4%, respectively, and 44.6%
    for fair quality embryos. Overall interobserver agreement was moderate (κ = 0.56,
    N = 136). The best agreement was achieved in the poor + top quality group (κ = 0.65,
    N = 77), while the agreement in the fair quality group was lower (κ = 0.25, N = 59).
    The DNN showed an overall accuracy rate of 62.5%, with accuracies of 62.2%, 61%
    and 65.6% for the poor, fair and top quality groups, respectively. The AUC for
    the DNN was higher than that of the embryologists overall (0.70 DNN vs 0.61 embryologists)
    as well as in all of the Gardner groups (DNN vs embryologists—Poor: 0.69 vs 0.62;
    Fair: 0.67 vs 0.53; Top: 0.77 vs 0.54).\r\n\r\nLIMITATIONS, REASONS FOR CAUTION:
    Blastocyst assessment was performed using video files acquired from time-lapse
    incubators, where each video contained data from a single focal plane. Clinical
    data regarding the underlying cause of infertility and endometrial thickness before
    the transfer was not available, yet may explain implantation failure and lower
    accuracy of IPGs. Implantation was defined as the presence of a gestational sac,
    whereas the detection of fetal heartbeat is a more robust marker of embryo viability.
    The raw data were anonymized to the extent that it was not possible to quantify
    the number of unique patients and cycles included in the study, potentially masking
    the effect of bias from a limited patient pool. Furthermore, the lack of demographic
    data makes it difficult to draw conclusions on how representative the dataset
    was of the wider population. Finally, embryologists were required to assess the
    implantation potential, not embryo quality. Although this is not the traditional
    approach to embryo evaluation, morphology/morphokinetics as a means of assessing
    embryo quality is believed to be strongly correlated with viability and, for some
    methods, implantation potential.\r\n\r\nWIDER IMPLICATIONS OF THE FINDINGS: Embryo
    selection is a key element in IVF success and continues to be a challenge. Improving
    the predictive ability could assist in optimizing implantation success rates and
    other clinical outcomes and could minimize the financial and emotional burden
    on the patient. This study demonstrates moderate agreement rates between embryologists,
    likely due to the subjective nature of embryo assessment. In particular, we found
    that average embryologist accuracy and agreement were significantly lower for
    fair quality embryos when compared with that for top and poor quality embryos.
    Using data-driven algorithms as an assistive tool may help IVF professionals increase
    success rates and promote much needed standardization in the IVF clinic. Our results
    indicate a need for further research regarding technological advancement in this
    field."
article_processing_charge: No
article_type: original
author:
- first_name: Daniel E
  full_name: Fordham, Daniel E
  last_name: Fordham
- first_name: Dror
  full_name: Rosentraub, Dror
  last_name: Rosentraub
- first_name: Avital L
  full_name: Polsky, Avital L
  last_name: Polsky
- first_name: Talia
  full_name: Aviram, Talia
  last_name: Aviram
- first_name: Yotam
  full_name: Wolf, Yotam
  last_name: Wolf
- first_name: Oriel
  full_name: Perl, Oriel
  last_name: Perl
- first_name: Asnat
  full_name: Devir, Asnat
  last_name: Devir
- first_name: Shahar
  full_name: Rosentraub, Shahar
  last_name: Rosentraub
- first_name: David H
  full_name: Silver, David H
  last_name: Silver
- first_name: Yael
  full_name: Gold Zamir, Yael
  last_name: Gold Zamir
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Miguel
  full_name: Lara Lara, Miguel
  last_name: Lara Lara
- first_name: Jara
  full_name: Ben Nagi, Jara
  last_name: Ben Nagi
- first_name: Adrian
  full_name: Alvarez, Adrian
  last_name: Alvarez
- first_name: Santiago
  full_name: Munné, Santiago
  last_name: Munné
citation:
  ama: 'Fordham DE, Rosentraub D, Polsky AL, et al. Embryologist agreement when assessing
    blastocyst implantation probability: Is data-driven prediction the solution to
    embryo assessment subjectivity? <i>Human Reproduction</i>. 2022;37(10):2275-2290.
    doi:<a href="https://doi.org/10.1093/humrep/deac171">10.1093/humrep/deac171</a>'
  apa: 'Fordham, D. E., Rosentraub, D., Polsky, A. L., Aviram, T., Wolf, Y., Perl,
    O., … Munné, S. (2022). Embryologist agreement when assessing blastocyst implantation
    probability: Is data-driven prediction the solution to embryo assessment subjectivity?
    <i>Human Reproduction</i>. Oxford University Press. <a href="https://doi.org/10.1093/humrep/deac171">https://doi.org/10.1093/humrep/deac171</a>'
  chicago: 'Fordham, Daniel E, Dror Rosentraub, Avital L Polsky, Talia Aviram, Yotam
    Wolf, Oriel Perl, Asnat Devir, et al. “Embryologist Agreement When Assessing Blastocyst
    Implantation Probability: Is Data-Driven Prediction the Solution to Embryo Assessment
    Subjectivity?” <i>Human Reproduction</i>. Oxford University Press, 2022. <a href="https://doi.org/10.1093/humrep/deac171">https://doi.org/10.1093/humrep/deac171</a>.'
  ieee: 'D. E. Fordham <i>et al.</i>, “Embryologist agreement when assessing blastocyst
    implantation probability: Is data-driven prediction the solution to embryo assessment
    subjectivity?,” <i>Human Reproduction</i>, vol. 37, no. 10. Oxford University
    Press, pp. 2275–2290, 2022.'
  ista: 'Fordham DE, Rosentraub D, Polsky AL, Aviram T, Wolf Y, Perl O, Devir A, Rosentraub
    S, Silver DH, Gold Zamir Y, Bronstein AM, Lara Lara M, Ben Nagi J, Alvarez A,
    Munné S. 2022. Embryologist agreement when assessing blastocyst implantation probability:
    Is data-driven prediction the solution to embryo assessment subjectivity? Human
    Reproduction. 37(10), 2275–2290.'
  mla: 'Fordham, Daniel E., et al. “Embryologist Agreement When Assessing Blastocyst
    Implantation Probability: Is Data-Driven Prediction the Solution to Embryo Assessment
    Subjectivity?” <i>Human Reproduction</i>, vol. 37, no. 10, Oxford University Press,
    2022, pp. 2275–90, doi:<a href="https://doi.org/10.1093/humrep/deac171">10.1093/humrep/deac171</a>.'
  short: D.E. Fordham, D. Rosentraub, A.L. Polsky, T. Aviram, Y. Wolf, O. Perl, A.
    Devir, S. Rosentraub, D.H. Silver, Y. Gold Zamir, A.M. Bronstein, M. Lara Lara,
    J. Ben Nagi, A. Alvarez, S. Munné, Human Reproduction 37 (2022) 2275–2290.
date_created: 2024-10-08T12:53:20Z
date_published: 2022-10-01T00:00:00Z
date_updated: 2024-10-14T09:54:40Z
day: '01'
doi: 10.1093/humrep/deac171
extern: '1'
intvolume: '        37'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1093/humrep/deac171
month: '10'
oa: 1
oa_version: Published Version
page: 2275-2290
publication: Human Reproduction
publication_identifier:
  eissn:
  - 1460-2350
  issn:
  - 0268-1161
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Embryologist agreement when assessing blastocyst implantation probability:
  Is data-driven prediction the solution to embryo assessment subjectivity?'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 37
year: '2022'
...
---
OA_place: repository
_id: '18224'
abstract:
- lang: eng
  text: Learning from one or few visual examples is one of the key capabilities of
    humans since early infancy, but is still a significant challenge for modern AI
    systems. While considerable progress has been achieved in few-shot learning from
    a few image examples, much less attention has been given to the verbal descriptions
    that are usually provided to infants when they are presented with a new object.
    In this paper, we focus on the role of additional semantics that can significantly
    facilitate few-shot visual learning. Building upon recent advances in few-shot
    learning with additional semantic information, we demonstrate that further improvements
    are possible by combining multiple and richer semantics (category labels, attributes,
    and natural language descriptions). Using these ideas, we offer the community
    new results on the popular miniImageNet and CUB few-shot benchmarks, comparing
    favorably to the previous state-of-the-art results for both visual only and visual
    plus semantics-based approaches. We also performed an ablation study investigating
    the components and design choices of our approach. Code available on github.com/EliSchwartz/mutiple-semantics.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Eli
  full_name: Schwartz, Eli
  last_name: Schwartz
- first_name: Leonid
  full_name: Karlinsky, Leonid
  last_name: Karlinsky
- first_name: Rogerio
  full_name: Feris, Rogerio
  last_name: Feris
- first_name: Raja
  full_name: Giryes, Raja
  last_name: Giryes
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
citation:
  ama: Schwartz E, Karlinsky L, Feris R, Giryes R, Bronstein AM. Baby steps towards
    few-shot learning with multiple semantics. <i>Pattern Recognition Letters</i>.
    2022;160:142-147. doi:<a href="https://doi.org/10.1016/j.patrec.2022.06.012">10.1016/j.patrec.2022.06.012</a>
  apa: Schwartz, E., Karlinsky, L., Feris, R., Giryes, R., &#38; Bronstein, A. M.
    (2022). Baby steps towards few-shot learning with multiple semantics. <i>Pattern
    Recognition Letters</i>. Elsevier. <a href="https://doi.org/10.1016/j.patrec.2022.06.012">https://doi.org/10.1016/j.patrec.2022.06.012</a>
  chicago: Schwartz, Eli, Leonid Karlinsky, Rogerio Feris, Raja Giryes, and Alex M.
    Bronstein. “Baby Steps towards Few-Shot Learning with Multiple Semantics.” <i>Pattern
    Recognition Letters</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.patrec.2022.06.012">https://doi.org/10.1016/j.patrec.2022.06.012</a>.
  ieee: E. Schwartz, L. Karlinsky, R. Feris, R. Giryes, and A. M. Bronstein, “Baby
    steps towards few-shot learning with multiple semantics,” <i>Pattern Recognition
    Letters</i>, vol. 160. Elsevier, pp. 142–147, 2022.
  ista: Schwartz E, Karlinsky L, Feris R, Giryes R, Bronstein AM. 2022. Baby steps
    towards few-shot learning with multiple semantics. Pattern Recognition Letters.
    160, 142–147.
  mla: Schwartz, Eli, et al. “Baby Steps towards Few-Shot Learning with Multiple Semantics.”
    <i>Pattern Recognition Letters</i>, vol. 160, Elsevier, 2022, pp. 142–47, doi:<a
    href="https://doi.org/10.1016/j.patrec.2022.06.012">10.1016/j.patrec.2022.06.012</a>.
  short: E. Schwartz, L. Karlinsky, R. Feris, R. Giryes, A.M. Bronstein, Pattern Recognition
    Letters 160 (2022) 142–147.
date_created: 2024-10-08T12:54:03Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2024-10-14T10:58:20Z
day: '01'
doi: 10.1016/j.patrec.2022.06.012
extern: '1'
external_id:
  arxiv:
  - '1906.01905'
intvolume: '       160'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1906.01905
month: '08'
oa: 1
oa_version: Preprint
page: 142-147
publication: Pattern Recognition Letters
publication_identifier:
  issn:
  - 0167-8655
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Baby steps towards few-shot learning with multiple semantics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 160
year: '2022'
...
---
OA_place: publisher
_id: '18225'
abstract:
- lang: eng
  text: "Isometric feature mapping is an established time-honored algorithm in manifold
    learning and non-linear dimensionality reduction. Its prominence can be attributed
    to the output of a coherent global low-dimensional representation of data by preserving
    intrinsic distances. In order to enable an efficient and more applicable isometric
    feature mapping, a diverse set of sophisticated advancements have been proposed
    to the original algorithm to incorporate important factors like sparsity of computation,
    conformality, topological constraints and spectral geometry. However, a significant
    shortcoming of most approaches is the dependence on large-scale dense-spectral
    decompositions and the inability to generalize to points far away from the sampling
    of the manifold.\r\nIn this paper, we explore an unsupervised deep learning approach
    for computing distance-preserving maps for non-linear dimensionality reduction.
    We demonstrate that our framework is general enough to incorporate all previous
    advancements and show a significantly improved local and non-local generalization
    of the isometric mapping. Our approach involves training with only a few landmark
    points and avoids the need for population of dense matrices as well as computing
    their spectral decomposition."
article_number: '104461'
article_processing_charge: No
article_type: original
author:
- first_name: Gautam
  full_name: Pai, Gautam
  last_name: Pai
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Ronen
  full_name: Talmon, Ronen
  last_name: Talmon
- first_name: Ron
  full_name: Kimmel, Ron
  last_name: Kimmel
citation:
  ama: Pai G, Bronstein AM, Talmon R, Kimmel R. Deep isometric maps. <i>Image and
    Vision Computing</i>. 2022;123. doi:<a href="https://doi.org/10.1016/j.imavis.2022.104461">10.1016/j.imavis.2022.104461</a>
  apa: Pai, G., Bronstein, A. M., Talmon, R., &#38; Kimmel, R. (2022). Deep isometric
    maps. <i>Image and Vision Computing</i>. Elsevier. <a href="https://doi.org/10.1016/j.imavis.2022.104461">https://doi.org/10.1016/j.imavis.2022.104461</a>
  chicago: Pai, Gautam, Alex M. Bronstein, Ronen Talmon, and Ron Kimmel. “Deep Isometric
    Maps.” <i>Image and Vision Computing</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.imavis.2022.104461">https://doi.org/10.1016/j.imavis.2022.104461</a>.
  ieee: G. Pai, A. M. Bronstein, R. Talmon, and R. Kimmel, “Deep isometric maps,”
    <i>Image and Vision Computing</i>, vol. 123. Elsevier, 2022.
  ista: Pai G, Bronstein AM, Talmon R, Kimmel R. 2022. Deep isometric maps. Image
    and Vision Computing. 123, 104461.
  mla: Pai, Gautam, et al. “Deep Isometric Maps.” <i>Image and Vision Computing</i>,
    vol. 123, 104461, Elsevier, 2022, doi:<a href="https://doi.org/10.1016/j.imavis.2022.104461">10.1016/j.imavis.2022.104461</a>.
  short: G. Pai, A.M. Bronstein, R. Talmon, R. Kimmel, Image and Vision Computing
    123 (2022).
date_created: 2024-10-08T12:54:22Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2024-10-14T11:03:26Z
day: '01'
doi: 10.1016/j.imavis.2022.104461
extern: '1'
intvolume: '       123'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.imavis.2022.104461
month: '07'
oa: 1
oa_version: Published Version
publication: Image and Vision Computing
publication_identifier:
  issn:
  - 0262-8856
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Deep isometric maps
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 123
year: '2022'
...
---
OA_place: publisher
OA_type: hybrid
_id: '18226'
abstract:
- lang: eng
  text: Spontaneous parametric downconversion (SPDC) in quantum optics is an invaluable
    resource for the realization of high-dimensional qudits with spatial modes of
    light. One of the main open challenges is how to directly generate a desirable
    qudit state in the SPDC process. This problem can be addressed through advanced
    computational learning methods; however, due to difficulties in modeling the SPDC
    process by a fully differentiable algorithm, progress has been limited. Here,
    we overcome these limitations and introduce a physically constrained and differentiable
    model, validated against experimental results for shaped pump beams and structured
    crystals, capable of learning the relevant interaction parameters in the process.
    We avoid any restrictions induced by the stochastic nature of our physical model
    and integrate the dynamic equations governing the evolution under the SPDC Hamiltonian.
    We solve the inverse problem of designing a nonlinear quantum optical system that
    achieves the desired quantum state of downconverted photon pairs. The desired
    states are defined using either the second-order correlations between different
    spatial modes or by specifying the required density matrix. By learning nonlinear
    photonic crystal structures as well as different pump shapes, we successfully
    show how to generate maximally entangled states. Furthermore, we simulate all-optical
    coherent control over the generated quantum state by actively changing the profile
    of the pump beam. Our work can be useful for applications such as novel designs
    of high-dimensional quantum key distribution and quantum information processing
    protocols. In addition, our method can be readily applied for controlling other
    degrees of freedom of light in the SPDC process, such as spectral and temporal
    properties, and may even be used in condensed-matter systems having a similar
    interaction Hamiltonian.
article_processing_charge: No
article_type: original
author:
- first_name: Eyal
  full_name: Rozenberg, Eyal
  last_name: Rozenberg
- first_name: Aviv
  full_name: Karnieli, Aviv
  last_name: Karnieli
- first_name: Ofir
  full_name: Yesharim, Ofir
  last_name: Yesharim
- first_name: Joshua
  full_name: Foley-Comer, Joshua
  last_name: Foley-Comer
- first_name: Sivan
  full_name: Trajtenberg-Mills, Sivan
  last_name: Trajtenberg-Mills
- first_name: Daniel
  full_name: Freedman, Daniel
  last_name: Freedman
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
- first_name: Ady
  full_name: Arie, Ady
  last_name: Arie
citation:
  ama: Rozenberg E, Karnieli A, Yesharim O, et al. Inverse design of spontaneous parametric
    downconversion for generation of high-dimensional qudits. <i>Optica</i>. 2022;9(6):602-615.
    doi:<a href="https://doi.org/10.1364/optica.451115">10.1364/optica.451115</a>
  apa: Rozenberg, E., Karnieli, A., Yesharim, O., Foley-Comer, J., Trajtenberg-Mills,
    S., Freedman, D., … Arie, A. (2022). Inverse design of spontaneous parametric
    downconversion for generation of high-dimensional qudits. <i>Optica</i>. Optica
    Publishing Group. <a href="https://doi.org/10.1364/optica.451115">https://doi.org/10.1364/optica.451115</a>
  chicago: Rozenberg, Eyal, Aviv Karnieli, Ofir Yesharim, Joshua Foley-Comer, Sivan
    Trajtenberg-Mills, Daniel Freedman, Alex M. Bronstein, and Ady Arie. “Inverse
    Design of Spontaneous Parametric Downconversion for Generation of High-Dimensional
    Qudits.” <i>Optica</i>. Optica Publishing Group, 2022. <a href="https://doi.org/10.1364/optica.451115">https://doi.org/10.1364/optica.451115</a>.
  ieee: E. Rozenberg <i>et al.</i>, “Inverse design of spontaneous parametric downconversion
    for generation of high-dimensional qudits,” <i>Optica</i>, vol. 9, no. 6. Optica
    Publishing Group, pp. 602–615, 2022.
  ista: Rozenberg E, Karnieli A, Yesharim O, Foley-Comer J, Trajtenberg-Mills S, Freedman
    D, Bronstein AM, Arie A. 2022. Inverse design of spontaneous parametric downconversion
    for generation of high-dimensional qudits. Optica. 9(6), 602–615.
  mla: Rozenberg, Eyal, et al. “Inverse Design of Spontaneous Parametric Downconversion
    for Generation of High-Dimensional Qudits.” <i>Optica</i>, vol. 9, no. 6, Optica
    Publishing Group, 2022, pp. 602–15, doi:<a href="https://doi.org/10.1364/optica.451115">10.1364/optica.451115</a>.
  short: E. Rozenberg, A. Karnieli, O. Yesharim, J. Foley-Comer, S. Trajtenberg-Mills,
    D. Freedman, A.M. Bronstein, A. Arie, Optica 9 (2022) 602–615.
date_created: 2024-10-08T12:54:43Z
date_published: 2022-06-06T00:00:00Z
date_updated: 2024-10-14T11:07:29Z
day: '06'
doi: 10.1364/optica.451115
extern: '1'
intvolume: '         9'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1364/OPTICA.451115
month: '06'
oa: 1
oa_version: Published Version
page: 602-615
publication: Optica
publication_identifier:
  issn:
  - 2334-2536
publication_status: published
publisher: Optica Publishing Group
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inverse design of spontaneous parametric downconversion for generation of high-dimensional
  qudits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2022'
...
---
_id: '18229'
abstract:
- lang: eng
  text: We present Self-Classifier – a novel self-supervised end-to-end classification
    learning approach. Self-Classifier learns labels and representations simultaneously
    in a single-stage end-to-end manner by optimizing for same-class prediction of
    two augmented views of the same sample. To guarantee non-degenerate solutions
    (i.e., solutions where all labels are assigned to the same class) we propose a
    mathematically motivated variant of the cross-entropy loss that has a uniform
    prior asserted on the predicted labels. In our theoretical analysis, we prove
    that degenerate solutions are not in the set of optimal solutions of our approach.
    Self-Classifier is simple to implement and scalable. Unlike other popular unsupervised
    classification and contrastive representation learning approaches, it does not
    require any form of pre-training, expectation-maximization, pseudo-labeling, external
    clustering, a second network, stop-gradient operation, or negative pairs. Despite
    its simplicity, our approach sets a new state of the art for unsupervised classification
    of ImageNet; and even achieves comparable to state-of-the-art results for unsupervised
    representation learning. Code is available at https://github.com/elad-amrani/self-classifier.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Elad
  full_name: Amrani, Elad
  last_name: Amrani
- first_name: Leonid
  full_name: Karlinsky, Leonid
  last_name: Karlinsky
- first_name: Alexander
  full_name: Bronstein, Alexander
  id: 58f3726e-7cba-11ef-ad8b-e6e8cb3904e6
  last_name: Bronstein
  orcid: 0000-0001-9699-8730
citation:
  ama: 'Amrani E, Karlinsky L, Bronstein AM. Self-supervised classification network.
    In: <i>17th European Conference on Computer Vision</i>. Vol 13691. Springer Nature;
    2022:116-132. doi:<a href="https://doi.org/10.1007/978-3-031-19821-2_7">10.1007/978-3-031-19821-2_7</a>'
  apa: 'Amrani, E., Karlinsky, L., &#38; Bronstein, A. M. (2022). Self-supervised
    classification network. In <i>17th European Conference on Computer Vision</i>
    (Vol. 13691, pp. 116–132). Tel Aviv, Israel: Springer Nature. <a href="https://doi.org/10.1007/978-3-031-19821-2_7">https://doi.org/10.1007/978-3-031-19821-2_7</a>'
  chicago: Amrani, Elad, Leonid Karlinsky, and Alex M. Bronstein. “Self-Supervised
    Classification Network.” In <i>17th European Conference on Computer Vision</i>,
    13691:116–32. Springer Nature, 2022. <a href="https://doi.org/10.1007/978-3-031-19821-2_7">https://doi.org/10.1007/978-3-031-19821-2_7</a>.
  ieee: E. Amrani, L. Karlinsky, and A. M. Bronstein, “Self-supervised classification
    network,” in <i>17th European Conference on Computer Vision</i>, Tel Aviv, Israel,
    2022, vol. 13691, pp. 116–132.
  ista: 'Amrani E, Karlinsky L, Bronstein AM. 2022. Self-supervised classification
    network. 17th European Conference on Computer Vision. ECCV: European Conference
    on Computer Vision, LNCS, vol. 13691, 116–132.'
  mla: Amrani, Elad, et al. “Self-Supervised Classification Network.” <i>17th European
    Conference on Computer Vision</i>, vol. 13691, Springer Nature, 2022, pp. 116–32,
    doi:<a href="https://doi.org/10.1007/978-3-031-19821-2_7">10.1007/978-3-031-19821-2_7</a>.
  short: E. Amrani, L. Karlinsky, A.M. Bronstein, in:, 17th European Conference on
    Computer Vision, Springer Nature, 2022, pp. 116–132.
conference:
  end_date: 2022-10-27
  location: Tel Aviv, Israel
  name: 'ECCV: European Conference on Computer Vision'
  start_date: 2022-10-23
date_created: 2024-10-08T12:55:44Z
date_published: 2022-10-23T00:00:00Z
date_updated: 2024-10-15T07:04:39Z
day: '23'
doi: 10.1007/978-3-031-19821-2_7
extern: '1'
external_id:
  arxiv:
  - '2103.10994'
intvolume: '     13691'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2103.10994
month: '10'
oa: 1
oa_version: None
page: 116-132
publication: 17th European Conference on Computer Vision
publication_identifier:
  eisbn:
  - '9783031198212'
  eissn:
  - 1611-3349
  isbn:
  - '9783031198205'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/elad-amrani/self-classifier
scopus_import: '1'
status: public
title: Self-supervised classification network
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13691
year: '2022'
...
---
_id: '18291'
article_processing_charge: No
author:
- first_name: Georgios
  full_name: Katsaros, Georgios
  id: 38DB5788-F248-11E8-B48F-1D18A9856A87
  last_name: Katsaros
  orcid: 0000-0001-8342-202X
- first_name: Daniel
  full_name: Jirovec, Daniel
  id: 4C473F58-F248-11E8-B48F-1D18A9856A87
  last_name: Jirovec
  orcid: 0000-0002-7197-4801
citation:
  ama: "Katsaros G, Jirovec D. Dynamics of Hole Singlet-Triplet Qubits with Large
    \U0001D454-Factor Differences. 2022. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18291\">10.15479/AT:ISTA:18291</a>"
  apa: "Katsaros, G., &#38; Jirovec, D. (2022). Dynamics of Hole Singlet-Triplet Qubits
    with Large \U0001D454-Factor Differences. Institute of Science and Technology
    Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:18291\">https://doi.org/10.15479/AT:ISTA:18291</a>"
  chicago: "Katsaros, Georgios, and Daniel Jirovec. “Dynamics of Hole Singlet-Triplet
    Qubits with Large \U0001D454-Factor Differences.” Institute of Science and Technology
    Austria, 2022. <a href=\"https://doi.org/10.15479/AT:ISTA:18291\">https://doi.org/10.15479/AT:ISTA:18291</a>."
  ieee: "G. Katsaros and D. Jirovec, “Dynamics of Hole Singlet-Triplet Qubits with
    Large \U0001D454-Factor Differences.” Institute of Science and Technology Austria,
    2022."
  ista: "Katsaros G, Jirovec D. 2022. Dynamics of Hole Singlet-Triplet Qubits with
    Large \U0001D454-Factor Differences, Institute of Science and Technology Austria,
    <a href=\"https://doi.org/10.15479/AT:ISTA:18291\">10.15479/AT:ISTA:18291</a>."
  mla: "Katsaros, Georgios, and Daniel Jirovec. <i>Dynamics of Hole Singlet-Triplet
    Qubits with Large \U0001D454-Factor Differences</i>. Institute of Science and
    Technology Austria, 2022, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18291\">10.15479/AT:ISTA:18291</a>."
  short: G. Katsaros, D. Jirovec, (2022).
corr_author: '1'
date_created: 2024-10-09T19:35:03Z
date_published: 2022-03-01T00:00:00Z
date_updated: 2025-04-15T07:15:24Z
day: '01'
department:
- _id: GeKa
doi: 10.15479/AT:ISTA:18291
file:
- access_level: open_access
  checksum: 3128dffbd09267b93c2d0b1425fd3ba2
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  date_created: 2024-10-09T19:31:35Z
  date_updated: 2024-10-09T19:31:35Z
  file_id: '18292'
  file_name: SOIPaper.zip
  file_size: 25566516
  relation: main_file
  success: 1
- access_level: open_access
  checksum: df077d2f4652afeb3bf100068e88aa48
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  creator: gkatsaro
  date_created: 2024-10-14T18:11:45Z
  date_updated: 2024-10-14T18:11:45Z
  file_id: '18442'
  file_name: Readme.txt
  file_size: 6776
  relation: main_file
  success: 1
file_date_updated: 2024-10-14T18:11:45Z
has_accepted_license: '1'
month: '03'
oa: 1
oa_version: None
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '10920'
    relation: research_paper
    status: public
status: public
title: "Dynamics of Hole Singlet-Triplet Qubits with Large \U0001D454-Factor Differences"
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2022'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18606'
abstract:
- lang: eng
  text: "Shear thickening is an intriguing rheological behaviour which consists in
    a brutal increase in the viscosity above a critical shear rate. It is famously
    encountered in suspensions of corn starch in water. Despite having been discovered
    in the early 1930's, its underlying mechanisms remained a mystery for a long time.
    In 2013–14, numerical and theoretical works [[1], [2], [3]] put forward a frictional
    transition scenario to explain this phenomenon.\r\nIn this talk, I will present
    experimental work investigating this frictional transition scenario. In order
    to test the ideas of this model, one has to go further than standard rheological
    techniques, since they do not provide access to the frictional state of the measured
    suspension. I will thus focus on the techniques that we developed in order to
    evidence the frictional transition and link it to the presence of a shear-thickening
    behaviour."
acknowledgement: "This talk presents parts of my PhD work, conducted at IUSTI in Marseille
  under the supervision of Yoël Forterre and Bloen Metzger. It aslo benefited from
  contributions from Antoine Bérut, and some of the data was acquired by Pauline Dame
  as part of a summer internship.\r\nThis work was supported by the European Research
  Council (ERC) under the European Union Horizon 2020 Research and Innovation program
  (ERC Grant 647384) and by the Labex MEC (ANR-10-LABX-0092) under the 647384) and
  by the A*MIDEX project (ANR-11-IDEX-0001-02) funded by the French government program
  Investissements d'Avenir, and by ANR ScienceFriction (No. ANR-18-CE30-0024)."
article_number: '100038'
article_processing_charge: No
article_type: original
author:
- first_name: Cécile
  full_name: Clavaud, Cécile
  id: 5f654c5d-04a1-11eb-ab36-ba9ffec58bd8
  last_name: Clavaud
  orcid: 0000-0002-1843-3803
citation:
  ama: 'Clavaud C. Shear thickening in dense suspensions: an experimental study. <i>Science
    Talks</i>. 2022;3. doi:<a href="https://doi.org/10.1016/j.sctalk.2022.100038">10.1016/j.sctalk.2022.100038</a>'
  apa: 'Clavaud, C. (2022). Shear thickening in dense suspensions: an experimental
    study. <i>Science Talks</i>. Elsevier. <a href="https://doi.org/10.1016/j.sctalk.2022.100038">https://doi.org/10.1016/j.sctalk.2022.100038</a>'
  chicago: 'Clavaud, Cécile. “Shear Thickening in Dense Suspensions: An Experimental
    Study.” <i>Science Talks</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.sctalk.2022.100038">https://doi.org/10.1016/j.sctalk.2022.100038</a>.'
  ieee: 'C. Clavaud, “Shear thickening in dense suspensions: an experimental study,”
    <i>Science Talks</i>, vol. 3. Elsevier, 2022.'
  ista: 'Clavaud C. 2022. Shear thickening in dense suspensions: an experimental study.
    Science Talks. 3, 100038.'
  mla: 'Clavaud, Cécile. “Shear Thickening in Dense Suspensions: An Experimental Study.”
    <i>Science Talks</i>, vol. 3, 100038, Elsevier, 2022, doi:<a href="https://doi.org/10.1016/j.sctalk.2022.100038">10.1016/j.sctalk.2022.100038</a>.'
  short: C. Clavaud, Science Talks 3 (2022).
corr_author: '1'
date_created: 2024-12-01T23:01:55Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2024-12-11T09:24:57Z
day: '01'
ddc:
- '530'
department:
- _id: ScWa
doi: 10.1016/j.sctalk.2022.100038
file:
- access_level: open_access
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  date_created: 2024-12-03T08:41:48Z
  date_updated: 2024-12-03T08:41:48Z
  file_id: '18607'
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  creator: dernst
  date_created: 2024-12-11T09:22:13Z
  date_updated: 2024-12-11T09:22:13Z
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  content_type: video/mp4
  creator: dernst
  date_created: 2024-12-11T09:22:19Z
  date_updated: 2024-12-11T09:22:19Z
  file_id: '18647'
  file_name: 2024_ScienceTalk__Clavaud_QA.mp4
  file_size: 58282147
  relation: supplementary_material
file_date_updated: 2024-12-11T09:22:19Z
has_accepted_license: '1'
intvolume: '         3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '08'
oa: 1
oa_version: Published Version
publication: Science Talks
publication_identifier:
  eissn:
  - 2772-5693
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Shear thickening in dense suspensions: an experimental study'
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2022'
...
---
_id: '12261'
abstract:
- lang: eng
  text: 'Dose–response relationships are a general concept for quantitatively describing
    biological systems across multiple scales, from the molecular to the whole-cell
    level. A clinically relevant example is the bacterial growth response to antibiotics,
    which is routinely characterized by dose–response curves. The shape of the dose–response
    curve varies drastically between antibiotics and plays a key role in treatment,
    drug interactions, and resistance evolution. However, the mechanisms shaping the
    dose–response curve remain largely unclear. Here, we show in Escherichia coli
    that the distinctively shallow dose–response curve of the antibiotic trimethoprim
    is caused by a negative growth-mediated feedback loop: Trimethoprim slows growth,
    which in turn weakens the effect of this antibiotic. At the molecular level, this
    feedback is caused by the upregulation of the drug target dihydrofolate reductase
    (FolA/DHFR). We show that this upregulation is not a specific response to trimethoprim
    but follows a universal trend line that depends primarily on the growth rate,
    irrespective of its cause. Rewiring the feedback loop alters the dose–response
    curve in a predictable manner, which we corroborate using a mathematical model
    of cellular resource allocation and growth. Our results indicate that growth-mediated
    feedback loops may shape drug responses more generally and could be exploited
    to design evolutionary traps that enable selection against drug resistance.'
acknowledged_ssus:
- _id: M-Shop
acknowledgement: This work was in part supported by Human Frontier Science Program
  GrantRGP0042/2013, Marie Curie Career Integration Grant303507, AustrianScience Fund
  (FWF) Grant P27201-B22, and German Research Foundation(DFG) Collaborative Research
  Center (SFB)1310to TB. SAA was supportedby the European Union’s Horizon2020Research
  and Innovation Programunder the Marie Skłodowska-Curie Grant agreement No707352.
  We wouldlike to thank the Bollenbach group for regular fruitful discussions. We
  areparticularly thankful for the technical assistance of Booshini Fernando andfor
  discussions of the theoretical aspects with Gerrit Ansmann. We areindebted to Bor
  Kavˇciˇc for invaluable advice, help with setting up theluciferase-based growth
  monitoring system, and for sharing plasmids. Weacknowledge the IST Austria Miba
  Machine Shop for their support inbuilding a housing for the stacker of the plate
  reader, which enabled thehigh-throughput luciferase-based experiments. We are grateful
  to RosalindAllen, Bor Kavˇciˇc and Dor Russ for feedback on the manuscript. Open
  Accessfunding enabled and organized by Projekt DEAL.
article_number: e10490
article_processing_charge: No
article_type: original
author:
- first_name: Andreas
  full_name: Angermayr, Andreas
  id: 4677C796-F248-11E8-B48F-1D18A9856A87
  last_name: Angermayr
  orcid: 0000-0001-8619-2223
- first_name: Tin Yau
  full_name: Pang, Tin Yau
  last_name: Pang
- first_name: Guillaume
  full_name: Chevereau, Guillaume
  last_name: Chevereau
- first_name: Karin
  full_name: Mitosch, Karin
  id: 39B66846-F248-11E8-B48F-1D18A9856A87
  last_name: Mitosch
- first_name: Martin J
  full_name: Lercher, Martin J
  last_name: Lercher
- first_name: Mark Tobias
  full_name: Bollenbach, Mark Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
citation:
  ama: Angermayr A, Pang TY, Chevereau G, Mitosch K, Lercher MJ, Bollenbach MT. Growth‐mediated
    negative feedback shapes quantitative antibiotic response. <i>Molecular Systems
    Biology</i>. 2022;18(9). doi:<a href="https://doi.org/10.15252/msb.202110490">10.15252/msb.202110490</a>
  apa: Angermayr, A., Pang, T. Y., Chevereau, G., Mitosch, K., Lercher, M. J., &#38;
    Bollenbach, M. T. (2022). Growth‐mediated negative feedback shapes quantitative
    antibiotic response. <i>Molecular Systems Biology</i>. Embo Press. <a href="https://doi.org/10.15252/msb.202110490">https://doi.org/10.15252/msb.202110490</a>
  chicago: Angermayr, Andreas, Tin Yau Pang, Guillaume Chevereau, Karin Mitosch, Martin
    J Lercher, and Mark Tobias Bollenbach. “Growth‐mediated Negative Feedback Shapes
    Quantitative Antibiotic Response.” <i>Molecular Systems Biology</i>. Embo Press,
    2022. <a href="https://doi.org/10.15252/msb.202110490">https://doi.org/10.15252/msb.202110490</a>.
  ieee: A. Angermayr, T. Y. Pang, G. Chevereau, K. Mitosch, M. J. Lercher, and M.
    T. Bollenbach, “Growth‐mediated negative feedback shapes quantitative antibiotic
    response,” <i>Molecular Systems Biology</i>, vol. 18, no. 9. Embo Press, 2022.
  ista: Angermayr A, Pang TY, Chevereau G, Mitosch K, Lercher MJ, Bollenbach MT. 2022.
    Growth‐mediated negative feedback shapes quantitative antibiotic response. Molecular
    Systems Biology. 18(9), e10490.
  mla: Angermayr, Andreas, et al. “Growth‐mediated Negative Feedback Shapes Quantitative
    Antibiotic Response.” <i>Molecular Systems Biology</i>, vol. 18, no. 9, e10490,
    Embo Press, 2022, doi:<a href="https://doi.org/10.15252/msb.202110490">10.15252/msb.202110490</a>.
  short: A. Angermayr, T.Y. Pang, G. Chevereau, K. Mitosch, M.J. Lercher, M.T. Bollenbach,
    Molecular Systems Biology 18 (2022).
date_created: 2023-01-16T09:58:34Z
date_published: 2022-09-01T00:00:00Z
date_updated: 2025-06-11T14:10:18Z
day: '01'
ddc:
- '570'
department:
- _id: ToBo
doi: 10.15252/msb.202110490
external_id:
  isi:
  - '000856482800001'
  pmid:
  - '36124745'
file:
- access_level: open_access
  checksum: 8b1d8f5ea20c8408acf466435fb6ae01
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-30T09:49:55Z
  date_updated: 2023-01-30T09:49:55Z
  file_id: '12446'
  file_name: 2022_MolecularSystemsBio_Angermayr.pdf
  file_size: 1098812
  relation: main_file
  success: 1
file_date_updated: 2023-01-30T09:49:55Z
has_accepted_license: '1'
intvolume: '        18'
isi: 1
issue: '9'
keyword:
- Applied Mathematics
- Computational Theory and Mathematics
- General Agricultural and Biological Sciences
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- Information Systems
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
publication: Molecular Systems Biology
publication_identifier:
  eissn:
  - 1744-4292
publication_status: published
publisher: Embo Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Growth‐mediated negative feedback shapes quantitative antibiotic response
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2022'
...
---
_id: '12262'
abstract:
- lang: eng
  text: The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that
    initiates cytoplasmic maturation of the large ribosomal subunit. Drg1 releases
    the shuttling maturation factor Rlp24 from pre-60S particles shortly after nuclear
    export, a strict requirement for downstream maturation. The molecular mechanism
    of release remained elusive. Here, we report a series of cryo-EM structures that
    captured the extraction of Rlp24 from pre-60S particles by Saccharomyces cerevisiae
    Drg1. These structures reveal that Arx1 and the eukaryote-specific rRNA expansion
    segment ES27 form a joint docking platform that positions Drg1 for efficient extraction
    of Rlp24 from the pre-ribosome. The tips of the Drg1 N domains thereby guide the
    Rlp24 C terminus into the central pore of the Drg1 hexamer, enabling extraction
    by a hand-over-hand translocation mechanism. Our results uncover substrate recognition
    and processing by Drg1 step by step and provide a comprehensive mechanistic picture
    of the conserved modus operandi of AAA-ATPases.
acknowledged_ssus:
- _id: EM-Fac
acknowledgement: "We thank M. Fromont-Racine, A. Johnson, J. Woolford, S. Rospert,
  J. P. G. Ballesta and\r\nE. Hurt for supplying antibodies. The work was supported
  by Boehringer Ingelheim (to\r\nD. H.), the Austrian Science Foundation FWF (grants
  32536 and 32977 to H. B.), the\r\nUK Medical Research Council (MR/T012412/1 to A.
  J. W.) and the German Research\r\nFoundation (Emmy Noether Programme STE 2517/1-1
  and STE 2517/5-1 to F.S.). We\r\nthank Norberto Escudero-Urquijo, Pablo Castro-Hartmann
  and K. Dent, Cambridge\r\nInstitute for Medical Research, for their help in cryo-EM
  during early phases of this\r\nproject. This research was supported by the Scientific
  Service Units of IST Austria through\r\nresources provided by the Electron Microscopy
  Facility. We thank S. Keller, Institute of\r\nMolecular Biosciences (Biophysics),
  University Graz for support with the quantification of\r\nthe SPR particle release
  assay. We thank I. Schaffner, University of Natural Resources and\r\nLife Sciences,
  Vienna for her help in early stages of the SPR experiments."
article_processing_charge: No
article_type: original
author:
- first_name: Michael
  full_name: Prattes, Michael
  last_name: Prattes
- first_name: Irina
  full_name: Grishkovskaya, Irina
  last_name: Grishkovskaya
- first_name: Victor-Valentin
  full_name: Hodirnau, Victor-Valentin
  id: 3661B498-F248-11E8-B48F-1D18A9856A87
  last_name: Hodirnau
- first_name: Christina
  full_name: Hetzmannseder, Christina
  last_name: Hetzmannseder
- first_name: Gertrude
  full_name: Zisser, Gertrude
  last_name: Zisser
- first_name: Carolin
  full_name: Sailer, Carolin
  last_name: Sailer
- first_name: Vasileios
  full_name: Kargas, Vasileios
  last_name: Kargas
- first_name: Mathias
  full_name: Loibl, Mathias
  last_name: Loibl
- first_name: Magdalena
  full_name: Gerhalter, Magdalena
  last_name: Gerhalter
- first_name: Lisa
  full_name: Kofler, Lisa
  last_name: Kofler
- first_name: Alan J.
  full_name: Warren, Alan J.
  last_name: Warren
- first_name: Florian
  full_name: Stengel, Florian
  last_name: Stengel
- first_name: David
  full_name: Haselbach, David
  last_name: Haselbach
- first_name: Helmut
  full_name: Bergler, Helmut
  last_name: Bergler
citation:
  ama: Prattes M, Grishkovskaya I, Hodirnau V-V, et al. Visualizing maturation factor
    extraction from the nascent ribosome by the AAA-ATPase Drg1. <i>Nature Structural
    &#38; Molecular Biology</i>. 2022;29(9):942-953. doi:<a href="https://doi.org/10.1038/s41594-022-00832-5">10.1038/s41594-022-00832-5</a>
  apa: Prattes, M., Grishkovskaya, I., Hodirnau, V.-V., Hetzmannseder, C., Zisser,
    G., Sailer, C., … Bergler, H. (2022). Visualizing maturation factor extraction
    from the nascent ribosome by the AAA-ATPase Drg1. <i>Nature Structural &#38; Molecular
    Biology</i>. Springer Nature. <a href="https://doi.org/10.1038/s41594-022-00832-5">https://doi.org/10.1038/s41594-022-00832-5</a>
  chicago: Prattes, Michael, Irina Grishkovskaya, Victor-Valentin Hodirnau, Christina
    Hetzmannseder, Gertrude Zisser, Carolin Sailer, Vasileios Kargas, et al. “Visualizing
    Maturation Factor Extraction from the Nascent Ribosome by the AAA-ATPase Drg1.”
    <i>Nature Structural &#38; Molecular Biology</i>. Springer Nature, 2022. <a href="https://doi.org/10.1038/s41594-022-00832-5">https://doi.org/10.1038/s41594-022-00832-5</a>.
  ieee: M. Prattes <i>et al.</i>, “Visualizing maturation factor extraction from the
    nascent ribosome by the AAA-ATPase Drg1,” <i>Nature Structural &#38; Molecular
    Biology</i>, vol. 29, no. 9. Springer Nature, pp. 942–953, 2022.
  ista: Prattes M, Grishkovskaya I, Hodirnau V-V, Hetzmannseder C, Zisser G, Sailer
    C, Kargas V, Loibl M, Gerhalter M, Kofler L, Warren AJ, Stengel F, Haselbach D,
    Bergler H. 2022. Visualizing maturation factor extraction from the nascent ribosome
    by the AAA-ATPase Drg1. Nature Structural &#38; Molecular Biology. 29(9), 942–953.
  mla: Prattes, Michael, et al. “Visualizing Maturation Factor Extraction from the
    Nascent Ribosome by the AAA-ATPase Drg1.” <i>Nature Structural &#38; Molecular
    Biology</i>, vol. 29, no. 9, Springer Nature, 2022, pp. 942–53, doi:<a href="https://doi.org/10.1038/s41594-022-00832-5">10.1038/s41594-022-00832-5</a>.
  short: M. Prattes, I. Grishkovskaya, V.-V. Hodirnau, C. Hetzmannseder, G. Zisser,
    C. Sailer, V. Kargas, M. Loibl, M. Gerhalter, L. Kofler, A.J. Warren, F. Stengel,
    D. Haselbach, H. Bergler, Nature Structural &#38; Molecular Biology 29 (2022)
    942–953.
date_created: 2023-01-16T09:59:06Z
date_published: 2022-09-12T00:00:00Z
date_updated: 2023-08-04T09:52:20Z
day: '12'
ddc:
- '570'
department:
- _id: EM-Fac
doi: 10.1038/s41594-022-00832-5
external_id:
  isi:
  - '000852942100004'
  pmid:
  - '36097293'
file:
- access_level: open_access
  checksum: 2d5c3ec01718fefd7553052b0b8a0793
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-30T10:00:04Z
  date_updated: 2023-01-30T10:00:04Z
  file_id: '12447'
  file_name: 2022_NatureStrucMolecBio_Prattes.pdf
  file_size: 9935057
  relation: main_file
  success: 1
file_date_updated: 2023-01-30T10:00:04Z
has_accepted_license: '1'
intvolume: '        29'
isi: 1
issue: '9'
keyword:
- Molecular Biology
- Structural Biology
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 942-953
pmid: 1
publication: Nature Structural & Molecular Biology
publication_identifier:
  eissn:
  - 1545-9985
  issn:
  - 1545-9993
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase
  Drg1
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 29
year: '2022'
...
---
_id: '12264'
abstract:
- lang: eng
  text: Reproductive isolation (RI) is a core concept in evolutionary biology. It
    has been the central focus of speciation research since the modern synthesis and
    is the basis by which biological species are defined. Despite this, the term is
    used in seemingly different ways, and attempts to quantify RI have used very different
    approaches. After showing that the field lacks a clear definition of the term,
    we attempt to clarify key issues, including what RI is, how it can be quantified
    in principle, and how it can be measured in practice. Following other definitions
    with a genetic focus, we propose that RI is a quantitative measure of the effect
    that genetic differences between populations have on gene flow. Specifically,
    RI compares the flow of neutral alleles in the presence of these genetic differences
    to the flow without any such differences. RI is thus greater than zero when genetic
    differences between populations reduce the flow of neutral alleles between populations.
    We show how RI can be quantified in a range of scenarios. A key conclusion is
    that RI depends strongly on circumstances—including the spatial, temporal and
    genomic context—making it difficult to compare across systems. After reviewing
    methods for estimating RI from data, we conclude that it is difficult to measure
    in practice. We discuss our findings in light of the goals of speciation research
    and encourage the use of methods for estimating RI that integrate organismal and
    genetic approaches.
acknowledgement: 'We are grateful to the participants of the ESEB satellite symposium
  ‘Understanding reproductive isolation: bridging conceptual barriers in  speciation  research’  in  2021  for  the  interesting  discussions  that  helped  us  clarify  the  thoughts  presented  in  this  article.  We  thank  Roger
  Butlin, Michael Turelli and two anonymous reviewers for their thoughtful comments
  on this manuscript. We are also very grateful to Roger Butlin and the Barton Group
  for the continued conversa-tions about RI. In addition, we thank all participants
  of the speciation survey. Part of this work was funded by the Austrian Science Fund
  FWF (grant P 32166)'
article_processing_charge: Yes (via OA deal)
article_type: review
author:
- first_name: Anja M
  full_name: Westram, Anja M
  id: 3C147470-F248-11E8-B48F-1D18A9856A87
  last_name: Westram
  orcid: 0000-0003-1050-4969
- first_name: Sean
  full_name: Stankowski, Sean
  id: 43161670-5719-11EA-8025-FABC3DDC885E
  last_name: Stankowski
- first_name: Parvathy
  full_name: Surendranadh, Parvathy
  id: 455235B8-F248-11E8-B48F-1D18A9856A87
  last_name: Surendranadh
  orcid: 0000-0001-6395-386X
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Westram AM, Stankowski S, Surendranadh P, Barton NH. What is reproductive isolation?
    <i>Journal of Evolutionary Biology</i>. 2022;35(9):1143-1164. doi:<a href="https://doi.org/10.1111/jeb.14005">10.1111/jeb.14005</a>
  apa: Westram, A. M., Stankowski, S., Surendranadh, P., &#38; Barton, N. H. (2022).
    What is reproductive isolation? <i>Journal of Evolutionary Biology</i>. Wiley.
    <a href="https://doi.org/10.1111/jeb.14005">https://doi.org/10.1111/jeb.14005</a>
  chicago: Westram, Anja M, Sean Stankowski, Parvathy Surendranadh, and Nicholas H
    Barton. “What Is Reproductive Isolation?” <i>Journal of Evolutionary Biology</i>.
    Wiley, 2022. <a href="https://doi.org/10.1111/jeb.14005">https://doi.org/10.1111/jeb.14005</a>.
  ieee: A. M. Westram, S. Stankowski, P. Surendranadh, and N. H. Barton, “What is
    reproductive isolation?,” <i>Journal of Evolutionary Biology</i>, vol. 35, no.
    9. Wiley, pp. 1143–1164, 2022.
  ista: Westram AM, Stankowski S, Surendranadh P, Barton NH. 2022. What is reproductive
    isolation? Journal of Evolutionary Biology. 35(9), 1143–1164.
  mla: Westram, Anja M., et al. “What Is Reproductive Isolation?” <i>Journal of Evolutionary
    Biology</i>, vol. 35, no. 9, Wiley, 2022, pp. 1143–64, doi:<a href="https://doi.org/10.1111/jeb.14005">10.1111/jeb.14005</a>.
  short: A.M. Westram, S. Stankowski, P. Surendranadh, N.H. Barton, Journal of Evolutionary
    Biology 35 (2022) 1143–1164.
corr_author: '1'
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doi: 10.1111/jeb.14005
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title: What is reproductive isolation?
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acknowledgement: We  are  very  grateful  to  the  authors  of  the  commentaries  for  the  interesting
  discussion and to Luke Holman for handling this set of manuscripts. Part of this
  work was funded by the Austrian Science Fund FWF (grant P 32166).
article_processing_charge: Yes (via OA deal)
article_type: letter_note
author:
- first_name: Anja M
  full_name: Westram, Anja M
  id: 3C147470-F248-11E8-B48F-1D18A9856A87
  last_name: Westram
  orcid: 0000-0003-1050-4969
- first_name: Sean
  full_name: Stankowski, Sean
  id: 43161670-5719-11EA-8025-FABC3DDC885E
  last_name: Stankowski
- first_name: Parvathy
  full_name: Surendranadh, Parvathy
  id: 455235B8-F248-11E8-B48F-1D18A9856A87
  last_name: Surendranadh
  orcid: 0000-0001-6395-386X
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: 'Westram AM, Stankowski S, Surendranadh P, Barton NH. Reproductive isolation,
    speciation, and the value of disagreement: A reply to the commentaries on ‘What
    is reproductive isolation?’ <i>Journal of Evolutionary Biology</i>. 2022;35(9):1200-1205.
    doi:<a href="https://doi.org/10.1111/jeb.14082">10.1111/jeb.14082</a>'
  apa: 'Westram, A. M., Stankowski, S., Surendranadh, P., &#38; Barton, N. H. (2022).
    Reproductive isolation, speciation, and the value of disagreement: A reply to
    the commentaries on ‘What is reproductive isolation?’ <i>Journal of Evolutionary
    Biology</i>. Wiley. <a href="https://doi.org/10.1111/jeb.14082">https://doi.org/10.1111/jeb.14082</a>'
  chicago: 'Westram, Anja M, Sean Stankowski, Parvathy Surendranadh, and Nicholas
    H Barton. “Reproductive Isolation, Speciation, and the Value of Disagreement:
    A Reply to the Commentaries on ‘What Is Reproductive Isolation?’” <i>Journal of
    Evolutionary Biology</i>. Wiley, 2022. <a href="https://doi.org/10.1111/jeb.14082">https://doi.org/10.1111/jeb.14082</a>.'
  ieee: 'A. M. Westram, S. Stankowski, P. Surendranadh, and N. H. Barton, “Reproductive
    isolation, speciation, and the value of disagreement: A reply to the commentaries
    on ‘What is reproductive isolation?,’” <i>Journal of Evolutionary Biology</i>,
    vol. 35, no. 9. Wiley, pp. 1200–1205, 2022.'
  ista: 'Westram AM, Stankowski S, Surendranadh P, Barton NH. 2022. Reproductive isolation,
    speciation, and the value of disagreement: A reply to the commentaries on ‘What
    is reproductive isolation?’ Journal of Evolutionary Biology. 35(9), 1200–1205.'
  mla: 'Westram, Anja M., et al. “Reproductive Isolation, Speciation, and the Value
    of Disagreement: A Reply to the Commentaries on ‘What Is Reproductive Isolation?’”
    <i>Journal of Evolutionary Biology</i>, vol. 35, no. 9, Wiley, 2022, pp. 1200–05,
    doi:<a href="https://doi.org/10.1111/jeb.14082">10.1111/jeb.14082</a>.'
  short: A.M. Westram, S. Stankowski, P. Surendranadh, N.H. Barton, Journal of Evolutionary
    Biology 35 (2022) 1200–1205.
corr_author: '1'
date_created: 2023-01-16T09:59:37Z
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doi: 10.1111/jeb.14082
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title: 'Reproductive isolation, speciation, and the value of disagreement: A reply
  to the commentaries on ‘What is reproductive isolation?’'
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---
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abstract:
- lang: eng
  text: The complexity of the microenvironment effects on cell response, show accumulating
    evidence that glioblastoma (GBM) migration and invasiveness are influenced by
    the mechanical rigidity of their surroundings. The epithelial–mesenchymal transition
    (EMT) is a well-recognized driving force of the invasive behavior of cancer. However,
    the primary mechanisms of EMT initiation and progression remain unclear. We have
    previously showed that certain substrate stiffness can selectively stimulate human
    GBM U251-MG and GL15 glioblastoma cell lines motility. The present study unifies
    several known EMT mediators to uncover the reason of the regulation and response
    to these stiffnesses. Our results revealed that changing the rigidity of the mechanical
    environment tuned the response of both cell lines through change in morphological
    features, epithelial-mesenchymal markers (E-, N-Cadherin), EGFR and ROS expressions
    in an interrelated manner. Specifically, a stiffer microenvironment induced a
    mesenchymal cell shape, a more fragmented morphology, higher intracellular cytosolic
    ROS expression and lower mitochondrial ROS. Finally, we observed that cells more
    motile showed a more depolarized mitochondrial membrane potential. Unravelling
    the process that regulates GBM cells’ infiltrative behavior could provide new
    opportunities for identification of new targets and less invasive approaches for
    treatment.
acknowledgement: "The research leading to these results has received funding from
  AIRC under IG 2021 - ID. 26328 project – P.I. Cortese Barbara and AIRC under MFAG
  2015 - ID. 16803 project – “P.I. Cortese Barbara”. The authors are also grateful
  to the ”Tecnopolo per la medicina di precisione” (TecnoMed Puglia) - Regione Puglia:
  DGR n.2117 del 21/11/2018, CUP: B84I18000540002 and “Tecnopolo di Nanotecnologia
  e Fotonica per la medicina di precisione” (TECNOMED) - FISR/MIUR-CNR: delibera CIPE
  n.3449 del 7-08-2017, CUP: B83B17000010001.\r\nWe thank Dr. Francesca Pagani for
  useful technical support. We thank also Irene Iacuitto, Giovanna Loffredo and Manuela
  Marchetti for practical administrative support."
article_number: '983507'
article_processing_charge: No
article_type: original
author:
- first_name: Bernadette
  full_name: Basilico, Bernadette
  id: 36035796-5ACA-11E9-A75E-7AF2E5697425
  last_name: Basilico
  orcid: 0000-0003-1843-3173
- first_name: Ilaria Elena
  full_name: Palamà, Ilaria Elena
  last_name: Palamà
- first_name: Stefania
  full_name: D’Amone, Stefania
  last_name: D’Amone
- first_name: Clotilde
  full_name: Lauro, Clotilde
  last_name: Lauro
- first_name: Maria
  full_name: Rosito, Maria
  last_name: Rosito
- first_name: Maddalena
  full_name: Grieco, Maddalena
  last_name: Grieco
- first_name: Patrizia
  full_name: Ratano, Patrizia
  last_name: Ratano
- first_name: Federica
  full_name: Cordella, Federica
  last_name: Cordella
- first_name: Caterina
  full_name: Sanchini, Caterina
  last_name: Sanchini
- first_name: Silvia
  full_name: Di Angelantonio, Silvia
  last_name: Di Angelantonio
- first_name: Davide
  full_name: Ragozzino, Davide
  last_name: Ragozzino
- first_name: Mariafrancesca
  full_name: Cascione, Mariafrancesca
  last_name: Cascione
- first_name: Giuseppe
  full_name: Gigli, Giuseppe
  last_name: Gigli
- first_name: Barbara
  full_name: Cortese, Barbara
  last_name: Cortese
citation:
  ama: Basilico B, Palamà IE, D’Amone S, et al. Substrate stiffness effect on molecular
    crosstalk of epithelial-mesenchymal transition mediators of human glioblastoma
    cells. <i>Frontiers in Oncology</i>. 2022;12. doi:<a href="https://doi.org/10.3389/fonc.2022.983507">10.3389/fonc.2022.983507</a>
  apa: Basilico, B., Palamà, I. E., D’Amone, S., Lauro, C., Rosito, M., Grieco, M.,
    … Cortese, B. (2022). Substrate stiffness effect on molecular crosstalk of epithelial-mesenchymal
    transition mediators of human glioblastoma cells. <i>Frontiers in Oncology</i>.
    Frontiers Media. <a href="https://doi.org/10.3389/fonc.2022.983507">https://doi.org/10.3389/fonc.2022.983507</a>
  chicago: Basilico, Bernadette, Ilaria Elena Palamà, Stefania D’Amone, Clotilde Lauro,
    Maria Rosito, Maddalena Grieco, Patrizia Ratano, et al. “Substrate Stiffness Effect
    on Molecular Crosstalk of Epithelial-Mesenchymal Transition Mediators of Human
    Glioblastoma Cells.” <i>Frontiers in Oncology</i>. Frontiers Media, 2022. <a href="https://doi.org/10.3389/fonc.2022.983507">https://doi.org/10.3389/fonc.2022.983507</a>.
  ieee: B. Basilico <i>et al.</i>, “Substrate stiffness effect on molecular crosstalk
    of epithelial-mesenchymal transition mediators of human glioblastoma cells,” <i>Frontiers
    in Oncology</i>, vol. 12. Frontiers Media, 2022.
  ista: Basilico B, Palamà IE, D’Amone S, Lauro C, Rosito M, Grieco M, Ratano P, Cordella
    F, Sanchini C, Di Angelantonio S, Ragozzino D, Cascione M, Gigli G, Cortese B.
    2022. Substrate stiffness effect on molecular crosstalk of epithelial-mesenchymal
    transition mediators of human glioblastoma cells. Frontiers in Oncology. 12, 983507.
  mla: Basilico, Bernadette, et al. “Substrate Stiffness Effect on Molecular Crosstalk
    of Epithelial-Mesenchymal Transition Mediators of Human Glioblastoma Cells.” <i>Frontiers
    in Oncology</i>, vol. 12, 983507, Frontiers Media, 2022, doi:<a href="https://doi.org/10.3389/fonc.2022.983507">10.3389/fonc.2022.983507</a>.
  short: B. Basilico, I.E. Palamà, S. D’Amone, C. Lauro, M. Rosito, M. Grieco, P.
    Ratano, F. Cordella, C. Sanchini, S. Di Angelantonio, D. Ragozzino, M. Cascione,
    G. Gigli, B. Cortese, Frontiers in Oncology 12 (2022).
date_created: 2023-01-16T10:00:28Z
date_published: 2022-08-25T00:00:00Z
date_updated: 2023-08-04T09:54:16Z
day: '25'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.3389/fonc.2022.983507
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intvolume: '        12'
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keyword:
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language:
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month: '08'
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oa_version: Published Version
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publication: Frontiers in Oncology
publication_identifier:
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title: Substrate stiffness effect on molecular crosstalk of epithelial-mesenchymal
  transition mediators of human glioblastoma cells
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type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2022'
...
