---
_id: '15228'
abstract:
- lang: eng
  text: We describe a new implementation of a broad-band soft X-ray polarimeter, substantially
    based on a previous design. This implementation, the Pioneer Soft X-ray Polarimeter
    (PiSoX) is a SmallSat, designed for NASA’s call for Astrophysics Pioneers, small
    missions that could be CubeSats, balloon experiments, or SmallSats. As in REDSoX,
    the grating arrangement is designed optimally for the purpose of polarimetry with
    broad-band focussing optics by matching the dispersion of the spectrometer channels
    to laterally graded multilayers (LGMLs). The system can achieve polarization modulation
    factors over 90%. For PiSoX, the optics are lightweight Si mirrors in a one-bounce
    parabolic configuration. High efficiency, blazed gratings from opposite sectors
    are oriented to disperse to a LGML forming a channel covering the wavelength range
    from 35 Å to 75 Å (165 - 350 eV). Upon satellite rotation, the intensities of
    the dispersed spectra, after reflection and polarizing by the LGMLs, give the
    three Stokes parameters needed to determine a source’s linear polarization fraction
    and orientation. The design can be extended to higher energies as LGMLs are developed
    further. We describe examples of the potential scientific return from instruments
    based on this design.
article_number: 114442Y
article_processing_charge: No
arxiv: 1
author:
- first_name: Herman L.
  full_name: Marshall, Herman L.
  last_name: Marshall
- first_name: Sarah
  full_name: Heine, Sarah
  last_name: Heine
- first_name: Alan
  full_name: Garner, Alan
  last_name: Garner
- first_name: Eric
  full_name: Gullikson, Eric
  last_name: Gullikson
- first_name: Moritz
  full_name: Guenther, Moritz
  last_name: Guenther
- first_name: Christopher
  full_name: Leitz, Christopher
  last_name: Leitz
- first_name: Rebecca
  full_name: Masterson, Rebecca
  last_name: Masterson
- first_name: Eric
  full_name: Miller, Eric
  last_name: Miller
- first_name: William
  full_name: Zhang, William
  last_name: Zhang
- first_name: Rozenn
  full_name: Boissay Malaquin, Rozenn
  last_name: Boissay Malaquin
- first_name: Ilaria
  full_name: Caiazzo, Ilaria
  id: 8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d
  last_name: Caiazzo
  orcid: 0000-0002-4770-5388
- first_name: Deepto
  full_name: Chakrabarty, Deepto
  last_name: Chakrabarty
- first_name: Rosemary
  full_name: Davidson, Rosemary
  last_name: Davidson
- first_name: Luigi
  full_name: Gallo, Luigi
  last_name: Gallo
- first_name: Ralf K.
  full_name: Heilmann, Ralf K.
  last_name: Heilmann
- first_name: Jeremy
  full_name: Heyl, Jeremy
  last_name: Heyl
- first_name: Erin
  full_name: Kara, Erin
  last_name: Kara
- first_name: Alan
  full_name: Marscher, Alan
  last_name: Marscher
- first_name: Norbert
  full_name: Schulz, Norbert
  last_name: Schulz
citation:
  ama: 'Marshall HL, Heine S, Garner A, et al. A small satellite version of a soft
    x-ray polarimeter. In: <i>Space Telescopes and Instrumentation 2020: Ultraviolet
    to Gamma Ray</i>. Vol 11444. SPIE; 2020. doi:<a href="https://doi.org/10.1117/12.2562811">10.1117/12.2562811</a>'
  apa: 'Marshall, H. L., Heine, S., Garner, A., Gullikson, E., Guenther, M., Leitz,
    C., … Schulz, N. (2020). A small satellite version of a soft x-ray polarimeter.
    In <i>Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray</i>
    (Vol. 11444). Virtual: SPIE. <a href="https://doi.org/10.1117/12.2562811">https://doi.org/10.1117/12.2562811</a>'
  chicago: 'Marshall, Herman L., Sarah Heine, Alan Garner, Eric Gullikson, Moritz
    Guenther, Christopher Leitz, Rebecca Masterson, et al. “A Small Satellite Version
    of a Soft X-Ray Polarimeter.” In <i>Space Telescopes and Instrumentation 2020:
    Ultraviolet to Gamma Ray</i>, Vol. 11444. SPIE, 2020. <a href="https://doi.org/10.1117/12.2562811">https://doi.org/10.1117/12.2562811</a>.'
  ieee: 'H. L. Marshall <i>et al.</i>, “A small satellite version of a soft x-ray
    polarimeter,” in <i>Space Telescopes and Instrumentation 2020: Ultraviolet to
    Gamma Ray</i>, Virtual, 2020, vol. 11444.'
  ista: 'Marshall HL, Heine S, Garner A, Gullikson E, Guenther M, Leitz C, Masterson
    R, Miller E, Zhang W, Boissay Malaquin R, Caiazzo I, Chakrabarty D, Davidson R,
    Gallo L, Heilmann RK, Heyl J, Kara E, Marscher A, Schulz N. 2020. A small satellite
    version of a soft x-ray polarimeter. Space Telescopes and Instrumentation 2020:
    Ultraviolet to Gamma Ray. Astronomical Telescopes + Instrumentation vol. 11444,
    114442Y.'
  mla: 'Marshall, Herman L., et al. “A Small Satellite Version of a Soft X-Ray Polarimeter.”
    <i>Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray</i>, vol.
    11444, 114442Y, SPIE, 2020, doi:<a href="https://doi.org/10.1117/12.2562811">10.1117/12.2562811</a>.'
  short: 'H.L. Marshall, S. Heine, A. Garner, E. Gullikson, M. Guenther, C. Leitz,
    R. Masterson, E. Miller, W. Zhang, R. Boissay Malaquin, I. Caiazzo, D. Chakrabarty,
    R. Davidson, L. Gallo, R.K. Heilmann, J. Heyl, E. Kara, A. Marscher, N. Schulz,
    in:, Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray, SPIE,
    2020.'
conference:
  end_date: 2020-12-18
  location: Virtual
  name: Astronomical Telescopes + Instrumentation
  start_date: 2020-12-14
date_created: 2024-03-26T10:36:20Z
date_published: 2020-12-13T00:00:00Z
date_updated: 2024-04-08T06:58:50Z
day: '13'
doi: 10.1117/12.2562811
extern: '1'
external_id:
  arxiv:
  - '2012.02829'
intvolume: '     11444'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2012.02829
month: '12'
oa: 1
oa_version: Preprint
publication: 'Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray'
publication_identifier:
  eissn:
  - 1996-756X
  isbn:
  - 978-151063675-0
publication_status: published
publisher: SPIE
quality_controlled: '1'
scopus_import: '1'
status: public
title: A small satellite version of a soft x-ray polarimeter
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11444
year: '2020'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19306'
acknowledgement: "We thank Maureen Barr, Martin Harterink, Max Heiman and Inna Nechipurenko
  for reagents, the Caenorhabditis Genetics Center for strains, and the Sengupta lab
  for comments and advice.\r\nThis work was funded in part by the NIH (R35 GM122463
  – P.S., and F32 DC018453 – A.P.), and the EMBO (ALTF 302-2019 – N.A-W.)."
article_number: '303'
article_processing_charge: Yes
article_type: original
author:
- first_name: Anna
  full_name: Kazatskaya, Anna
  last_name: Kazatskaya
- first_name: Lisa
  full_name: Yuan, Lisa
  last_name: Yuan
- first_name: Niko Paresh
  full_name: Amin-Wetzel, Niko Paresh
  id: E95D3014-9D8C-11E9-9C80-D2F8E5697425
  last_name: Amin-Wetzel
- first_name: Alison
  full_name: Philbrook, Alison
  last_name: Philbrook
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
- first_name: Piali
  full_name: Sengupta, Piali
  last_name: Sengupta
citation:
  ama: Kazatskaya A, Yuan L, Amin-Wetzel NP, Philbrook A, de Bono M, Sengupta P. The
    URX oxygen-sensing neurons in C. elegans are ciliated. <i>microPublication Biology</i>.
    2020;2020(9). doi:<a href="https://doi.org/10.17912/MICROPUB.BIOLOGY.000303">10.17912/MICROPUB.BIOLOGY.000303</a>
  apa: Kazatskaya, A., Yuan, L., Amin-Wetzel, N. P., Philbrook, A., de Bono, M., &#38;
    Sengupta, P. (2020). The URX oxygen-sensing neurons in C. elegans are ciliated.
    <i>MicroPublication Biology</i>. Caltech Library. <a href="https://doi.org/10.17912/MICROPUB.BIOLOGY.000303">https://doi.org/10.17912/MICROPUB.BIOLOGY.000303</a>
  chicago: Kazatskaya, Anna, Lisa Yuan, Niko Paresh Amin-Wetzel, Alison Philbrook,
    Mario de Bono, and Piali Sengupta. “The URX Oxygen-Sensing Neurons in C. Elegans
    Are Ciliated.” <i>MicroPublication Biology</i>. Caltech Library, 2020. <a href="https://doi.org/10.17912/MICROPUB.BIOLOGY.000303">https://doi.org/10.17912/MICROPUB.BIOLOGY.000303</a>.
  ieee: A. Kazatskaya, L. Yuan, N. P. Amin-Wetzel, A. Philbrook, M. de Bono, and P.
    Sengupta, “The URX oxygen-sensing neurons in C. elegans are ciliated,” <i>microPublication
    Biology</i>, vol. 2020, no. 9. Caltech Library, 2020.
  ista: Kazatskaya A, Yuan L, Amin-Wetzel NP, Philbrook A, de Bono M, Sengupta P.
    2020. The URX oxygen-sensing neurons in C. elegans are ciliated. microPublication
    Biology. 2020(9), 303.
  mla: Kazatskaya, Anna, et al. “The URX Oxygen-Sensing Neurons in C. Elegans Are
    Ciliated.” <i>MicroPublication Biology</i>, vol. 2020, no. 9, 303, Caltech Library,
    2020, doi:<a href="https://doi.org/10.17912/MICROPUB.BIOLOGY.000303">10.17912/MICROPUB.BIOLOGY.000303</a>.
  short: A. Kazatskaya, L. Yuan, N.P. Amin-Wetzel, A. Philbrook, M. de Bono, P. Sengupta,
    MicroPublication Biology 2020 (2020).
date_created: 2025-03-07T08:21:51Z
date_published: 2020-09-20T00:00:00Z
date_updated: 2025-03-11T08:30:41Z
day: '20'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.17912/MICROPUB.BIOLOGY.000303
external_id:
  pmid:
  - '33005885'
file:
- access_level: open_access
  checksum: 14a7cad20775521ce85e0e3c77aa7936
  content_type: application/pdf
  creator: dernst
  date_created: 2025-03-11T08:27:40Z
  date_updated: 2025-03-11T08:27:40Z
  file_id: '19383'
  file_name: 2020_MicroPublBio_Kazatskaya.pdf
  file_size: 1486239
  relation: main_file
  success: 1
file_date_updated: 2025-03-11T08:27:40Z
has_accepted_license: '1'
intvolume: '      2020'
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
publication: microPublication Biology
publication_identifier:
  eissn:
  - 2578-9430
publication_status: published
publisher: Caltech Library
quality_controlled: '1'
status: public
title: The URX oxygen-sensing neurons in C. elegans are ciliated
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2020
year: '2020'
...
---
_id: '5681'
abstract:
- lang: eng
  text: 'We introduce dynamically warping grids for adaptive liquid simulation. Our
    primary contributions are a strategy for dynamically deforming regular grids over
    the course of a simulation and a method for efficiently utilizing these deforming
    grids for liquid simulation. Prior work has shown that unstructured grids are
    very effective for adaptive fluid simulations. However, unstructured grids often
    lead to complicated implementations and a poor cache hit rate due to inconsistent
    memory access. Regular grids, on the other hand, provide a fast, fixed memory
    access pattern and straightforward implementation. Our method combines the advantages
    of both: we leverage the simplicity of regular grids while still achieving practical
    and controllable spatial adaptivity. We demonstrate that our method enables adaptive
    simulations that are fast, flexible, and robust to null-space issues. At the same
    time, our method is simple to implement and takes advantage of existing highly-tuned
    algorithms.'
acknowledged_ssus:
- _id: ScienComp
acknowledgement: This work was partially supported by JSPS Grant-in-Aid forYoung Scientists
  (Start-up) 16H07410, the ERC StartingGrantsrealFlow(StG-2015-637014) andBigSplash(StG-2014-638176).
  This research was supported by the Scientific Ser-vice Units (SSU) of IST Austria
  through resources providedby Scientific Computing. We would like to express my grati-tude
  to Nobuyuki Umetani and Tomas Skrivan for insight-ful discussion.
article_processing_charge: No
article_type: original
author:
- first_name: Ibayashi
  full_name: Hikaru, Ibayashi
  last_name: Hikaru
- first_name: Christopher J
  full_name: Wojtan, Christopher J
  id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
  last_name: Wojtan
  orcid: 0000-0001-6646-5546
- first_name: Nils
  full_name: Thuerey, Nils
  last_name: Thuerey
- first_name: Takeo
  full_name: Igarashi, Takeo
  last_name: Igarashi
- first_name: Ryoichi
  full_name: Ando, Ryoichi
  last_name: Ando
citation:
  ama: Hikaru I, Wojtan C, Thuerey N, Igarashi T, Ando R. Simulating liquids on dynamically
    warping grids. <i>IEEE Transactions on Visualization and Computer Graphics</i>.
    2020;26(6):2288-2302. doi:<a href="https://doi.org/10.1109/TVCG.2018.2883628">10.1109/TVCG.2018.2883628</a>
  apa: Hikaru, I., Wojtan, C., Thuerey, N., Igarashi, T., &#38; Ando, R. (2020). Simulating
    liquids on dynamically warping grids. <i>IEEE Transactions on Visualization and
    Computer Graphics</i>. IEEE. <a href="https://doi.org/10.1109/TVCG.2018.2883628">https://doi.org/10.1109/TVCG.2018.2883628</a>
  chicago: Hikaru, Ibayashi, Chris Wojtan, Nils Thuerey, Takeo Igarashi, and Ryoichi
    Ando. “Simulating Liquids on Dynamically Warping Grids.” <i>IEEE Transactions
    on Visualization and Computer Graphics</i>. IEEE, 2020. <a href="https://doi.org/10.1109/TVCG.2018.2883628">https://doi.org/10.1109/TVCG.2018.2883628</a>.
  ieee: I. Hikaru, C. Wojtan, N. Thuerey, T. Igarashi, and R. Ando, “Simulating liquids
    on dynamically warping grids,” <i>IEEE Transactions on Visualization and Computer
    Graphics</i>, vol. 26, no. 6. IEEE, pp. 2288–2302, 2020.
  ista: Hikaru I, Wojtan C, Thuerey N, Igarashi T, Ando R. 2020. Simulating liquids
    on dynamically warping grids. IEEE Transactions on Visualization and Computer
    Graphics. 26(6), 2288–2302.
  mla: Hikaru, Ibayashi, et al. “Simulating Liquids on Dynamically Warping Grids.”
    <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 26, no.
    6, IEEE, 2020, pp. 2288–302, doi:<a href="https://doi.org/10.1109/TVCG.2018.2883628">10.1109/TVCG.2018.2883628</a>.
  short: I. Hikaru, C. Wojtan, N. Thuerey, T. Igarashi, R. Ando, IEEE Transactions
    on Visualization and Computer Graphics 26 (2020) 2288–2302.
date_created: 2018-12-16T22:59:21Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2025-07-10T11:52:55Z
day: '01'
ddc:
- '006'
department:
- _id: ChWo
doi: 10.1109/TVCG.2018.2883628
external_id:
  isi:
  - '000532295600014'
  pmid:
  - '30507534'
file:
- access_level: open_access
  checksum: 8d4c55443a0ee335bb5bb652de503042
  content_type: application/pdf
  creator: wojtan
  date_created: 2020-10-08T08:34:53Z
  date_updated: 2020-10-08T08:34:53Z
  file_id: '8626'
  file_name: preprint.pdf
  file_size: 21910098
  relation: main_file
  success: 1
file_date_updated: 2020-10-08T08:34:53Z
has_accepted_license: '1'
intvolume: '        26'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 2288-2302
pmid: 1
publication: IEEE Transactions on Visualization and Computer Graphics
publication_identifier:
  eissn:
  - 1941-0506
  issn:
  - 1077-2626
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Simulating liquids on dynamically warping grids
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 26
year: '2020'
...
---
_id: '6358'
abstract:
- lang: eng
  text: We study dynamical optimal transport metrics between density matricesassociated
    to symmetric Dirichlet forms on finite-dimensional C∗-algebras.  Our settingcovers  arbitrary  skew-derivations  and  it  provides  a  unified  framework  that  simultaneously  generalizes  recently  constructed  transport  metrics  for  Markov  chains,  Lindblad  equations,  and  the  Fermi  Ornstein–Uhlenbeck  semigroup.   We  develop  a  non-nommutative
    differential calculus that allows us to obtain non-commutative Ricci curvature  bounds,  logarithmic  Sobolev  inequalities,  transport-entropy  inequalities,  andspectral
    gap estimates.
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Eric A.
  full_name: Carlen, Eric A.
  last_name: Carlen
- first_name: Jan
  full_name: Maas, Jan
  id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
  last_name: Maas
  orcid: 0000-0002-0845-1338
citation:
  ama: Carlen EA, Maas J. Non-commutative calculus, optimal transport and functional
    inequalities  in dissipative quantum systems. <i>Journal of Statistical Physics</i>.
    2020;178(2):319-378. doi:<a href="https://doi.org/10.1007/s10955-019-02434-w">10.1007/s10955-019-02434-w</a>
  apa: Carlen, E. A., &#38; Maas, J. (2020). Non-commutative calculus, optimal transport
    and functional inequalities  in dissipative quantum systems. <i>Journal of Statistical
    Physics</i>. Springer Nature. <a href="https://doi.org/10.1007/s10955-019-02434-w">https://doi.org/10.1007/s10955-019-02434-w</a>
  chicago: Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport
    and Functional Inequalities  in Dissipative Quantum Systems.” <i>Journal of Statistical
    Physics</i>. Springer Nature, 2020. <a href="https://doi.org/10.1007/s10955-019-02434-w">https://doi.org/10.1007/s10955-019-02434-w</a>.
  ieee: E. A. Carlen and J. Maas, “Non-commutative calculus, optimal transport and
    functional inequalities  in dissipative quantum systems,” <i>Journal of Statistical
    Physics</i>, vol. 178, no. 2. Springer Nature, pp. 319–378, 2020.
  ista: Carlen EA, Maas J. 2020. Non-commutative calculus, optimal transport and functional
    inequalities  in dissipative quantum systems. Journal of Statistical Physics.
    178(2), 319–378.
  mla: Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport
    and Functional Inequalities  in Dissipative Quantum Systems.” <i>Journal of Statistical
    Physics</i>, vol. 178, no. 2, Springer Nature, 2020, pp. 319–78, doi:<a href="https://doi.org/10.1007/s10955-019-02434-w">10.1007/s10955-019-02434-w</a>.
  short: E.A. Carlen, J. Maas, Journal of Statistical Physics 178 (2020) 319–378.
corr_author: '1'
date_created: 2019-04-30T07:34:18Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2025-06-12T07:27:20Z
day: '01'
ddc:
- '500'
department:
- _id: JaMa
doi: 10.1007/s10955-019-02434-w
ec_funded: 1
external_id:
  arxiv:
  - '1811.04572'
  isi:
  - '000498933300001'
  pmid:
  - '33223567'
file:
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  checksum: 7b04befbdc0d4982c0ee945d25d19872
  content_type: application/pdf
  creator: dernst
  date_created: 2019-12-23T12:03:09Z
  date_updated: 2020-07-14T12:47:28Z
  file_id: '7209'
  file_name: 2019_JourStatistPhysics_Carlen.pdf
  file_size: 905538
  relation: main_file
file_date_updated: 2020-07-14T12:47:28Z
has_accepted_license: '1'
intvolume: '       178'
isi: 1
issue: '2'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 319-378
pmid: 1
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
  name: IST Austria Open Access Fund
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '716117'
  name: Optimal Transport and Stochastic Dynamics
- _id: 260482E2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: F06504
  name: Taming Complexity in Partial Differential Systems
publication: Journal of Statistical Physics
publication_identifier:
  eissn:
  - 1572-9613
  issn:
  - 0022-4715
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1007/s10955-020-02671-4
scopus_import: '1'
status: public
title: Non-commutative calculus, optimal transport and functional inequalities  in
  dissipative quantum systems
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 178
year: '2020'
...
---
_id: '6359'
abstract:
- lang: eng
  text: The strong rate of convergence of the Euler-Maruyama scheme for nondegenerate
    SDEs with irregular drift coefficients is considered. In the case of α-Hölder
    drift in the recent literature the rate α/2 was proved in many related situations.
    By exploiting the regularising effect of the noise more efficiently, we show that
    the rate is in fact arbitrarily close to 1/2 for all α>0. The result extends to
    Dini continuous coefficients, while in d=1 also to all bounded measurable coefficients.
article_number: '82'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Konstantinos
  full_name: Dareiotis, Konstantinos
  last_name: Dareiotis
- first_name: Mate
  full_name: Gerencser, Mate
  id: 44ECEDF2-F248-11E8-B48F-1D18A9856A87
  last_name: Gerencser
citation:
  ama: Dareiotis K, Gerencser M. On the regularisation of the noise for the Euler-Maruyama
    scheme with irregular drift. <i>Electronic Journal of Probability</i>. 2020;25.
    doi:<a href="https://doi.org/10.1214/20-EJP479">10.1214/20-EJP479</a>
  apa: Dareiotis, K., &#38; Gerencser, M. (2020). On the regularisation of the noise
    for the Euler-Maruyama scheme with irregular drift. <i>Electronic Journal of Probability</i>.
    Institute of Mathematical Statistics. <a href="https://doi.org/10.1214/20-EJP479">https://doi.org/10.1214/20-EJP479</a>
  chicago: Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of
    the Noise for the Euler-Maruyama Scheme with Irregular Drift.” <i>Electronic Journal
    of Probability</i>. Institute of Mathematical Statistics, 2020. <a href="https://doi.org/10.1214/20-EJP479">https://doi.org/10.1214/20-EJP479</a>.
  ieee: K. Dareiotis and M. Gerencser, “On the regularisation of the noise for the
    Euler-Maruyama scheme with irregular drift,” <i>Electronic Journal of Probability</i>,
    vol. 25. Institute of Mathematical Statistics, 2020.
  ista: Dareiotis K, Gerencser M. 2020. On the regularisation of the noise for the
    Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability.
    25, 82.
  mla: Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of the
    Noise for the Euler-Maruyama Scheme with Irregular Drift.” <i>Electronic Journal
    of Probability</i>, vol. 25, 82, Institute of Mathematical Statistics, 2020, doi:<a
    href="https://doi.org/10.1214/20-EJP479">10.1214/20-EJP479</a>.
  short: K. Dareiotis, M. Gerencser, Electronic Journal of Probability 25 (2020).
date_created: 2019-04-30T07:40:17Z
date_published: 2020-07-16T00:00:00Z
date_updated: 2023-10-16T09:22:50Z
day: '16'
ddc:
- '510'
department:
- _id: JaMa
doi: 10.1214/20-EJP479
external_id:
  arxiv:
  - '1812.04583'
  isi:
  - '000550150700001'
file:
- access_level: open_access
  checksum: 8e7c42e72596f6889d786e8e8b89994f
  content_type: application/pdf
  creator: dernst
  date_created: 2020-09-21T13:15:02Z
  date_updated: 2020-09-21T13:15:02Z
  file_id: '8549'
  file_name: 2020_EJournProbab_Dareiotis.pdf
  file_size: 273042
  relation: main_file
  success: 1
file_date_updated: 2020-09-21T13:15:02Z
has_accepted_license: '1'
intvolume: '        25'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Electronic Journal of Probability
publication_identifier:
  eissn:
  - 1083-6489
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the regularisation of the noise for the Euler-Maruyama scheme with irregular
  drift
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2020'
...
---
OA_place: repository
OA_type: green
_id: '19807'
abstract:
- lang: eng
  text: Microstructures can be carefully designed to reveal the quantum phase of the
    wave-like nature of electrons in a metal. Here, we report phase-coherent oscillations
    of out-of-plane magnetoresistance in the layered delafossites PdCoO2 and PtCoO2.
    The oscillation period is equivalent to that determined by the magnetic flux quantum,
    h/e, threading an area defined by the atomic interlayer separation and the sample
    width, where h is Planck’s constant and e is the charge of an electron. The phase
    of the electron wave function appears robust over length scales exceeding 10 micrometers
    and persisting up to temperatures of T > 50 kelvin. We show that the experimental
    signal stems from a periodic field modulation of the out-of-plane hopping. These
    results demonstrate extraordinary single-particle quantum coherence lengths in
    delafossites.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Carsten
  full_name: Putzke, Carsten
  last_name: Putzke
- first_name: Maja D.
  full_name: Bachmann, Maja D.
  last_name: Bachmann
- first_name: Philippa
  full_name: McGuinness, Philippa
  last_name: McGuinness
- first_name: Elina
  full_name: Zhakina, Elina
  last_name: Zhakina
- first_name: Veronika
  full_name: Sunko, Veronika
  id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
  last_name: Sunko
  orcid: 0000-0003-2724-3523
- first_name: Marcin
  full_name: Konczykowski, Marcin
  last_name: Konczykowski
- first_name: Takashi
  full_name: Oka, Takashi
  last_name: Oka
- first_name: Roderich
  full_name: Moessner, Roderich
  last_name: Moessner
- first_name: Ady
  full_name: Stern, Ady
  last_name: Stern
- first_name: Markus
  full_name: König, Markus
  last_name: König
- first_name: Seunghyun
  full_name: Khim, Seunghyun
  last_name: Khim
- first_name: Andrew P.
  full_name: Mackenzie, Andrew P.
  last_name: Mackenzie
- first_name: Philip J.W.
  full_name: Moll, Philip J.W.
  last_name: Moll
citation:
  ama: Putzke C, Bachmann MD, McGuinness P, et al. h/e oscillations in interlayer
    transport of delafossites. <i>Science</i>. 2020;368(6496):1234-1238. doi:<a href="https://doi.org/10.1126/science.aay8413">10.1126/science.aay8413</a>
  apa: Putzke, C., Bachmann, M. D., McGuinness, P., Zhakina, E., Sunko, V., Konczykowski,
    M., … Moll, P. J. W. (2020). h/e oscillations in interlayer transport of delafossites.
    <i>Science</i>. American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.aay8413">https://doi.org/10.1126/science.aay8413</a>
  chicago: Putzke, Carsten, Maja D. Bachmann, Philippa McGuinness, Elina Zhakina,
    Veronika Sunko, Marcin Konczykowski, Takashi Oka, et al. “H/e Oscillations in
    Interlayer Transport of Delafossites.” <i>Science</i>. American Association for
    the Advancement of Science, 2020. <a href="https://doi.org/10.1126/science.aay8413">https://doi.org/10.1126/science.aay8413</a>.
  ieee: C. Putzke <i>et al.</i>, “h/e oscillations in interlayer transport of delafossites,”
    <i>Science</i>, vol. 368, no. 6496. American Association for the Advancement of
    Science, pp. 1234–1238, 2020.
  ista: Putzke C, Bachmann MD, McGuinness P, Zhakina E, Sunko V, Konczykowski M, Oka
    T, Moessner R, Stern A, König M, Khim S, Mackenzie AP, Moll PJW. 2020. h/e oscillations
    in interlayer transport of delafossites. Science. 368(6496), 1234–1238.
  mla: Putzke, Carsten, et al. “H/e Oscillations in Interlayer Transport of Delafossites.”
    <i>Science</i>, vol. 368, no. 6496, American Association for the Advancement of
    Science, 2020, pp. 1234–38, doi:<a href="https://doi.org/10.1126/science.aay8413">10.1126/science.aay8413</a>.
  short: C. Putzke, M.D. Bachmann, P. McGuinness, E. Zhakina, V. Sunko, M. Konczykowski,
    T. Oka, R. Moessner, A. Stern, M. König, S. Khim, A.P. Mackenzie, P.J.W. Moll,
    Science 368 (2020) 1234–1238.
date_created: 2025-06-10T09:11:34Z
date_published: 2020-06-12T00:00:00Z
date_updated: 2025-06-10T11:27:54Z
day: '12'
doi: 10.1126/science.aay8413
extern: '1'
external_id:
  arxiv:
  - '1902.07331'
  pmid:
  - '32527829'
intvolume: '       368'
issue: '6496'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1902.07331
month: '06'
oa: 1
oa_version: Preprint
page: 1234-1238
pmid: 1
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: h/e oscillations in interlayer transport of delafossites
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 368
year: '2020'
...
---
OA_place: publisher
OA_type: gold
_id: '19812'
abstract:
- lang: eng
  text: A nearly free electron metal and a Mott insulating state can be thought of
    as opposite ends of the spectrum of possibilities for the motion of electrons
    in a solid. Understanding their interaction lies at the heart of the correlated
    electron problem. In the magnetic oxide metal PdCrO2, nearly free and Mott-localized
    electrons exist in alternating layers, forming natural heterostructures. Using
    angle-resolved photoemission spectroscopy, quantitatively supported by a strong
    coupling analysis, we show that the coupling between these layers leads to an
    “intertwined” excitation that is a convolution of the charge spectrum of the metallic
    layer and the spin susceptibility of the Mott layer. Our findings establish PdCrO2
    as a model system in which to probe Kondo lattice physics and also open new routes
    to use the a priori nonmagnetic probe of photoemission to gain insights into the
    spin susceptibility of correlated electron materials.
article_number: aaz0611
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Veronika
  full_name: Sunko, Veronika
  id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
  last_name: Sunko
  orcid: 0000-0003-2724-3523
- first_name: F.
  full_name: Mazzola, F.
  last_name: Mazzola
- first_name: S.
  full_name: Kitamura, S.
  last_name: Kitamura
- first_name: S.
  full_name: Khim, S.
  last_name: Khim
- first_name: P.
  full_name: Kushwaha, P.
  last_name: Kushwaha
- first_name: O. J.
  full_name: Clark, O. J.
  last_name: Clark
- first_name: M. D.
  full_name: Watson, M. D.
  last_name: Watson
- first_name: I.
  full_name: Marković, I.
  last_name: Marković
- first_name: D.
  full_name: Biswas, D.
  last_name: Biswas
- first_name: L.
  full_name: Pourovskii, L.
  last_name: Pourovskii
- first_name: T. K.
  full_name: Kim, T. K.
  last_name: Kim
- first_name: T.-L.
  full_name: Lee, T.-L.
  last_name: Lee
- first_name: P. K.
  full_name: Thakur, P. K.
  last_name: Thakur
- first_name: H.
  full_name: Rosner, H.
  last_name: Rosner
- first_name: A.
  full_name: Georges, A.
  last_name: Georges
- first_name: R.
  full_name: Moessner, R.
  last_name: Moessner
- first_name: T.
  full_name: Oka, T.
  last_name: Oka
- first_name: A. P.
  full_name: Mackenzie, A. P.
  last_name: Mackenzie
- first_name: P. D. C.
  full_name: King, P. D. C.
  last_name: King
citation:
  ama: Sunko V, Mazzola F, Kitamura S, et al. Probing spin correlations using angle-resolved
    photoemission in a coupled metallic/Mott insulator system. <i>Science Advances</i>.
    2020;6(6). doi:<a href="https://doi.org/10.1126/sciadv.aaz0611">10.1126/sciadv.aaz0611</a>
  apa: Sunko, V., Mazzola, F., Kitamura, S., Khim, S., Kushwaha, P., Clark, O. J.,
    … King, P. D. C. (2020). Probing spin correlations using angle-resolved photoemission
    in a coupled metallic/Mott insulator system. <i>Science Advances</i>. American
    Association for the Advancement of Science. <a href="https://doi.org/10.1126/sciadv.aaz0611">https://doi.org/10.1126/sciadv.aaz0611</a>
  chicago: Sunko, Veronika, F. Mazzola, S. Kitamura, S. Khim, P. Kushwaha, O. J. Clark,
    M. D. Watson, et al. “Probing Spin Correlations Using Angle-Resolved Photoemission
    in a Coupled Metallic/Mott Insulator System.” <i>Science Advances</i>. American
    Association for the Advancement of Science, 2020. <a href="https://doi.org/10.1126/sciadv.aaz0611">https://doi.org/10.1126/sciadv.aaz0611</a>.
  ieee: V. Sunko <i>et al.</i>, “Probing spin correlations using angle-resolved photoemission
    in a coupled metallic/Mott insulator system,” <i>Science Advances</i>, vol. 6,
    no. 6. American Association for the Advancement of Science, 2020.
  ista: Sunko V, Mazzola F, Kitamura S, Khim S, Kushwaha P, Clark OJ, Watson MD, Marković
    I, Biswas D, Pourovskii L, Kim TK, Lee T-L, Thakur PK, Rosner H, Georges A, Moessner
    R, Oka T, Mackenzie AP, King PDC. 2020. Probing spin correlations using angle-resolved
    photoemission in a coupled metallic/Mott insulator system. Science Advances. 6(6),
    aaz0611.
  mla: Sunko, Veronika, et al. “Probing Spin Correlations Using Angle-Resolved Photoemission
    in a Coupled Metallic/Mott Insulator System.” <i>Science Advances</i>, vol. 6,
    no. 6, aaz0611, American Association for the Advancement of Science, 2020, doi:<a
    href="https://doi.org/10.1126/sciadv.aaz0611">10.1126/sciadv.aaz0611</a>.
  short: V. Sunko, F. Mazzola, S. Kitamura, S. Khim, P. Kushwaha, O.J. Clark, M.D.
    Watson, I. Marković, D. Biswas, L. Pourovskii, T.K. Kim, T.-L. Lee, P.K. Thakur,
    H. Rosner, A. Georges, R. Moessner, T. Oka, A.P. Mackenzie, P.D.C. King, Science
    Advances 6 (2020).
date_created: 2025-06-10T09:14:20Z
date_published: 2020-02-07T00:00:00Z
date_updated: 2025-06-10T13:12:09Z
day: '07'
doi: 10.1126/sciadv.aaz0611
extern: '1'
external_id:
  arxiv:
  - '1809.08972'
  pmid:
  - '32128385'
has_accepted_license: '1'
intvolume: '         6'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1126/sciadv.aaz0611
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Probing spin correlations using angle-resolved photoemission in a coupled metallic/Mott
  insulator system
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2020'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19823'
abstract:
- lang: eng
  text: The delafossite metals PdCoO2, PtCoO2, and PdCrO2 are among the highest conductivity
    materials known, with low-temperature mean free paths of tens of microns in the
    best as-grown single crystals. A key question is whether these very low resistive
    scattering rates result from strongly suppressed backscattering due to special
    features of the electronic structure or are a consequence of highly unusual levels
    of crystalline perfection. We report the results of experiments in which high-energy
    electron irradiation was used to introduce point disorder to the Pd and Pt layers
    in which the conduction occurs. We obtain the cross section for formation of Frenkel
    pairs in absolute units, and cross-check our analysis with first-principles calculations
    of the relevant atomic displacement energies. We observe an increase of resistivity
    that is linear in defect density with a slope consistent with scattering in the
    unitary limit. Our results enable us to deduce that the as-grown crystals contain
    extremely low levels of in-plane defects of approximately 0.001%. This confirms
    that crystalline perfection is the most important factor in realizing the long
    mean free paths and highlights how unusual these delafossite metals are in comparison
    with the vast majority of other multicomponent oxides and alloys. We discuss the
    implications of our findings for future materials research.
article_number: '021018'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Veronika
  full_name: Sunko, Veronika
  id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
  last_name: Sunko
  orcid: 0000-0003-2724-3523
- first_name: P. H.
  full_name: McGuinness, P. H.
  last_name: McGuinness
- first_name: C. S.
  full_name: Chang, C. S.
  last_name: Chang
- first_name: E.
  full_name: Zhakina, E.
  last_name: Zhakina
- first_name: S.
  full_name: Khim, S.
  last_name: Khim
- first_name: C. E.
  full_name: Dreyer, C. E.
  last_name: Dreyer
- first_name: M.
  full_name: Konczykowski, M.
  last_name: Konczykowski
- first_name: H.
  full_name: Borrmann, H.
  last_name: Borrmann
- first_name: P. J. W.
  full_name: Moll, P. J. W.
  last_name: Moll
- first_name: M.
  full_name: König, M.
  last_name: König
- first_name: D. A.
  full_name: Muller, D. A.
  last_name: Muller
- first_name: A. P.
  full_name: Mackenzie, A. P.
  last_name: Mackenzie
citation:
  ama: Sunko V, McGuinness PH, Chang CS, et al. Controlled introduction of defects
    to delafossite metals by electron irradiation. <i>Physical Review X</i>. 2020;10(2).
    doi:<a href="https://doi.org/10.1103/physrevx.10.021018">10.1103/physrevx.10.021018</a>
  apa: Sunko, V., McGuinness, P. H., Chang, C. S., Zhakina, E., Khim, S., Dreyer,
    C. E., … Mackenzie, A. P. (2020). Controlled introduction of defects to delafossite
    metals by electron irradiation. <i>Physical Review X</i>. American Physical Society.
    <a href="https://doi.org/10.1103/physrevx.10.021018">https://doi.org/10.1103/physrevx.10.021018</a>
  chicago: Sunko, Veronika, P. H. McGuinness, C. S. Chang, E. Zhakina, S. Khim, C. E.
    Dreyer, M. Konczykowski, et al. “Controlled Introduction of Defects to Delafossite
    Metals by Electron Irradiation.” <i>Physical Review X</i>. American Physical Society,
    2020. <a href="https://doi.org/10.1103/physrevx.10.021018">https://doi.org/10.1103/physrevx.10.021018</a>.
  ieee: V. Sunko <i>et al.</i>, “Controlled introduction of defects to delafossite
    metals by electron irradiation,” <i>Physical Review X</i>, vol. 10, no. 2. American
    Physical Society, 2020.
  ista: Sunko V, McGuinness PH, Chang CS, Zhakina E, Khim S, Dreyer CE, Konczykowski
    M, Borrmann H, Moll PJW, König M, Muller DA, Mackenzie AP. 2020. Controlled introduction
    of defects to delafossite metals by electron irradiation. Physical Review X. 10(2),
    021018.
  mla: Sunko, Veronika, et al. “Controlled Introduction of Defects to Delafossite
    Metals by Electron Irradiation.” <i>Physical Review X</i>, vol. 10, no. 2, 021018,
    American Physical Society, 2020, doi:<a href="https://doi.org/10.1103/physrevx.10.021018">10.1103/physrevx.10.021018</a>.
  short: V. Sunko, P.H. McGuinness, C.S. Chang, E. Zhakina, S. Khim, C.E. Dreyer,
    M. Konczykowski, H. Borrmann, P.J.W. Moll, M. König, D.A. Muller, A.P. Mackenzie,
    Physical Review X 10 (2020).
date_created: 2025-06-10T09:21:11Z
date_published: 2020-04-24T00:00:00Z
date_updated: 2025-06-10T13:08:51Z
day: '24'
doi: 10.1103/physrevx.10.021018
extern: '1'
external_id:
  arxiv:
  - '2001.01471'
intvolume: '        10'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1103/PhysRevX.10.021018
month: '04'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
  eissn:
  - 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Controlled introduction of defects to delafossite metals by electron irradiation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2020'
...
---
OA_place: publisher
_id: '19986'
abstract:
- lang: eng
  text: 'For non-probabilistic programs, a key question in static analysis is termination,
    which asks whether a given program terminates under a given initial condition.
    In the presence of probabilistic behaviour, there are two fundamental extensions
    of the termination question: (a) the almost-sure termination question, which asks
    whether the termination probability is 1; and (b) the bounded-time termination
    question, which asks whether the expected termination time is bounded. There are
    many active research directions to address these two questions; one important
    such direction is the use of martingale theory for termination analysis. In this
    chapter, we survey the main techniques of the martingale-based approach to the
    termination analysis of probabilistic programs.'
acknowledgement: "Krishnendu Chatterjee is supported by the Austrian Science Fund
  (FWF) NFN\r\nGrant No. S11407-N23 (RiSE/SHiNE), and COST Action GAMENET. Hongfei
  Fu\r\nis supported by the National Natural Science Foundation of China (NSFC) Grant\r\nNo.
  61802254. Petr Novotný is supported by the Czech Science Foundation grant\r\nNo.
  GJ19-15134Y."
article_processing_charge: No
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Hongfei
  full_name: Fu, Hongfei
  id: 3AAD03D6-F248-11E8-B48F-1D18A9856A87
  last_name: Fu
- first_name: Petr
  full_name: Novotný, Petr
  id: 3CC3B868-F248-11E8-B48F-1D18A9856A87
  last_name: Novotný
citation:
  ama: 'Chatterjee K, Fu H, Novotný P. Termination Analysis of Probabilistic Programs
    with Martingales. In: <i>Foundations of Probabilistic Programming</i>. Cambridge
    University Press; 2020:221-258. doi:<a href="https://doi.org/10.1017/9781108770750.008">10.1017/9781108770750.008</a>'
  apa: Chatterjee, K., Fu, H., &#38; Novotný, P. (2020). Termination Analysis of Probabilistic
    Programs with Martingales. In <i>Foundations of Probabilistic Programming</i>
    (pp. 221–258). Cambridge University Press. <a href="https://doi.org/10.1017/9781108770750.008">https://doi.org/10.1017/9781108770750.008</a>
  chicago: Chatterjee, Krishnendu, Hongfei Fu, and Petr Novotný. “Termination Analysis
    of Probabilistic Programs with Martingales.” In <i>Foundations of Probabilistic
    Programming</i>, 221–58. Cambridge University Press, 2020. <a href="https://doi.org/10.1017/9781108770750.008">https://doi.org/10.1017/9781108770750.008</a>.
  ieee: K. Chatterjee, H. Fu, and P. Novotný, “Termination Analysis of Probabilistic
    Programs with Martingales,” in <i>Foundations of Probabilistic Programming</i>,
    Cambridge University Press, 2020, pp. 221–258.
  ista: 'Chatterjee K, Fu H, Novotný P. 2020.Termination Analysis of Probabilistic
    Programs with Martingales. In: Foundations of Probabilistic Programming. , 221–258.'
  mla: Chatterjee, Krishnendu, et al. “Termination Analysis of Probabilistic Programs
    with Martingales.” <i>Foundations of Probabilistic Programming</i>, Cambridge
    University Press, 2020, pp. 221–58, doi:<a href="https://doi.org/10.1017/9781108770750.008">10.1017/9781108770750.008</a>.
  short: K. Chatterjee, H. Fu, P. Novotný, in:, Foundations of Probabilistic Programming,
    Cambridge University Press, 2020, pp. 221–258.
corr_author: '1'
date_created: 2025-07-10T13:28:51Z
date_published: 2020-11-18T00:00:00Z
date_updated: 2025-09-23T12:10:25Z
day: '18'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1017/9781108770750.008
file:
- access_level: open_access
  checksum: 28ece115e8d2d9263e253a598e7caef2
  content_type: application/pdf
  creator: dernst
  date_created: 2025-09-23T12:03:09Z
  date_updated: 2025-09-23T12:03:09Z
  file_id: '20380'
  file_name: 2020_ProbProgramming_Chatterjee.pdf
  file_size: 316681
  relation: main_file
  success: 1
file_date_updated: 2025-09-23T12:03:09Z
has_accepted_license: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 221-258
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
publication: Foundations of Probabilistic Programming
publication_identifier:
  eisbn:
  - '9781108770750'
  isbn:
  - '9781108488518'
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
status: public
title: Termination Analysis of Probabilistic Programs with Martingales
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
OA_place: repository
OA_type: green
_id: '20766'
abstract:
- lang: eng
  text: Reversible catalytic reactions operate under thermodynamic control, and thus,
    establishing a selective catalytic system poses a considerable challenge. Herein,
    we report a reversible transfer hydrocyanation protocol that exhibits high selectivity
    for the thermodynamically less favorable branched isomer. Selectivity is achieved
    by exploiting the lower barrier for C–CN oxidative addition and reductive elimination
    at benzylic positions in the absence of a cocatalytic Lewis acid. Through the
    design of a novel type of HCN donor, a practical, branched-selective, HCN-free
    transfer hydrocyanation was realized. The synthetically useful resolution of a
    mixture of branched and linear nitrile isomers was also demonstrated to underline
    the value of reversible and selective transfer reactions. In a broader context,
    this work demonstrates that high kinetic selectivity can be achieved in reversible
    transfer reactions, thus opening new horizons for their synthetic applications.
article_processing_charge: No
article_type: original
author:
- first_name: Benjamin N.
  full_name: Bhawal, Benjamin N.
  last_name: Bhawal
- first_name: Julia
  full_name: Reisenbauer, Julia
  id: 51d862e9-36ee-11f0-86d3-8534c85a5496
  last_name: Reisenbauer
- first_name: Christian
  full_name: Ehinger, Christian
  last_name: Ehinger
- first_name: Bill
  full_name: Morandi, Bill
  last_name: Morandi
citation:
  ama: 'Bhawal BN, Reisenbauer J, Ehinger C, Morandi B. Overcoming selectivity issues
    in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic control.
    <i>Journal of the American Chemical Society</i>. 2020;142(25):10914-10920. doi:<a
    href="https://doi.org/10.1021/jacs.0c03184">10.1021/jacs.0c03184</a>'
  apa: 'Bhawal, B. N., Reisenbauer, J., Ehinger, C., &#38; Morandi, B. (2020). Overcoming
    selectivity issues in reversible catalysis: A transfer hydrocyanation exhibiting
    high kinetic control. <i>Journal of the American Chemical Society</i>. American
    Chemical Society. <a href="https://doi.org/10.1021/jacs.0c03184">https://doi.org/10.1021/jacs.0c03184</a>'
  chicago: 'Bhawal, Benjamin N., Julia Reisenbauer, Christian Ehinger, and Bill Morandi.
    “Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation
    Exhibiting High Kinetic Control.” <i>Journal of the American Chemical Society</i>.
    American Chemical Society, 2020. <a href="https://doi.org/10.1021/jacs.0c03184">https://doi.org/10.1021/jacs.0c03184</a>.'
  ieee: 'B. N. Bhawal, J. Reisenbauer, C. Ehinger, and B. Morandi, “Overcoming selectivity
    issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic
    control,” <i>Journal of the American Chemical Society</i>, vol. 142, no. 25. American
    Chemical Society, pp. 10914–10920, 2020.'
  ista: 'Bhawal BN, Reisenbauer J, Ehinger C, Morandi B. 2020. Overcoming selectivity
    issues in reversible catalysis: A transfer hydrocyanation exhibiting high kinetic
    control. Journal of the American Chemical Society. 142(25), 10914–10920.'
  mla: 'Bhawal, Benjamin N., et al. “Overcoming Selectivity Issues in Reversible Catalysis:
    A Transfer Hydrocyanation Exhibiting High Kinetic Control.” <i>Journal of the
    American Chemical Society</i>, vol. 142, no. 25, American Chemical Society, 2020,
    pp. 10914–20, doi:<a href="https://doi.org/10.1021/jacs.0c03184">10.1021/jacs.0c03184</a>.'
  short: B.N. Bhawal, J. Reisenbauer, C. Ehinger, B. Morandi, Journal of the American
    Chemical Society 142 (2020) 10914–10920.
date_created: 2025-12-09T14:25:37Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2025-12-16T12:10:08Z
day: '01'
doi: 10.1021/jacs.0c03184
extern: '1'
external_id:
  pmid:
  - '32478515'
intvolume: '       142'
issue: '25'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: 10.26434/chemrxiv.11931633.v1
month: '06'
oa: 1
oa_version: Preprint
page: 10914-10920
pmid: 1
publication: Journal of the American Chemical Society
publication_identifier:
  eissn:
  - 1520-5126
  issn:
  - 0002-7863
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Overcoming selectivity issues in reversible catalysis: A transfer hydrocyanation
  exhibiting high kinetic control'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 142
year: '2020'
...
---
_id: '10012'
abstract:
- lang: eng
  text: We prove that in the absence of topological changes, the notion of BV solutions
    to planar multiphase mean curvature flow does not allow for a mechanism for (unphysical)
    non-uniqueness. Our approach is based on the local structure of the energy landscape
    near a classical evolution by mean curvature. Mean curvature flow being the gradient
    flow of the surface energy functional, we develop a gradient-flow analogue of
    the notion of calibrations. Just like the existence of a calibration guarantees
    that one has reached a global minimum in the energy landscape, the existence of
    a "gradient flow calibration" ensures that the route of steepest descent in the
    energy landscape is unique and stable.
acknowledgement: Parts of the paper were written during the visit of the authors to
  the Hausdorff Research Institute for Mathematics (HIM), University of Bonn, in the
  framework of the trimester program “Evolution of Interfaces”. The support and the
  hospitality of HIM are gratefully acknowledged. This project has received funding
  from the European Union’s Horizon 2020 research and innovation programme under the
  Marie Sklodowska-Curie Grant Agreement No. 665385.
article_number: '2003.05478'
article_processing_charge: No
arxiv: 1
author:
- first_name: Julian L
  full_name: Fischer, Julian L
  id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
  last_name: Fischer
  orcid: 0000-0002-0479-558X
- first_name: Sebastian
  full_name: Hensel, Sebastian
  id: 4D23B7DA-F248-11E8-B48F-1D18A9856A87
  last_name: Hensel
  orcid: 0000-0001-7252-8072
- first_name: Tim
  full_name: Laux, Tim
  last_name: Laux
- first_name: Thilo
  full_name: Simon, Thilo
  last_name: Simon
citation:
  ama: 'Fischer JL, Hensel S, Laux T, Simon T. The local structure of the energy landscape
    in multiphase mean curvature flow: weak-strong uniqueness and stability of evolutions.
    <i>arXiv</i>. doi:<a href="https://doi.org/10.48550/arXiv.2003.05478">10.48550/arXiv.2003.05478</a>'
  apa: 'Fischer, J. L., Hensel, S., Laux, T., &#38; Simon, T. (n.d.). The local structure
    of the energy landscape in multiphase mean curvature flow: weak-strong uniqueness
    and stability of evolutions. <i>arXiv</i>. <a href="https://doi.org/10.48550/arXiv.2003.05478">https://doi.org/10.48550/arXiv.2003.05478</a>'
  chicago: 'Fischer, Julian L, Sebastian Hensel, Tim Laux, and Thilo Simon. “The Local
    Structure of the Energy Landscape in Multiphase Mean Curvature Flow: Weak-Strong
    Uniqueness and Stability of Evolutions.” <i>ArXiv</i>, n.d. <a href="https://doi.org/10.48550/arXiv.2003.05478">https://doi.org/10.48550/arXiv.2003.05478</a>.'
  ieee: 'J. L. Fischer, S. Hensel, T. Laux, and T. Simon, “The local structure of
    the energy landscape in multiphase mean curvature flow: weak-strong uniqueness
    and stability of evolutions,” <i>arXiv</i>. .'
  ista: 'Fischer JL, Hensel S, Laux T, Simon T. The local structure of the energy
    landscape in multiphase mean curvature flow: weak-strong uniqueness and stability
    of evolutions. arXiv, 2003.05478.'
  mla: 'Fischer, Julian L., et al. “The Local Structure of the Energy Landscape in
    Multiphase Mean Curvature Flow: Weak-Strong Uniqueness and Stability of Evolutions.”
    <i>ArXiv</i>, 2003.05478, doi:<a href="https://doi.org/10.48550/arXiv.2003.05478">10.48550/arXiv.2003.05478</a>.'
  short: J.L. Fischer, S. Hensel, T. Laux, T. Simon, ArXiv (n.d.).
date_created: 2021-09-13T12:17:11Z
date_published: 2020-03-11T00:00:00Z
date_updated: 2026-04-08T07:01:01Z
day: '11'
department:
- _id: JuFi
doi: 10.48550/arXiv.2003.05478
ec_funded: 1
external_id:
  arxiv:
  - '2003.05478'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2003.05478
month: '03'
oa: 1
oa_version: Preprint
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: arXiv
publication_status: draft
related_material:
  record:
  - id: '10007'
    relation: dissertation_contains
    status: public
status: public
title: 'The local structure of the energy landscape in multiphase mean curvature flow:
  weak-strong uniqueness and stability of evolutions'
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '10022'
abstract:
- lang: eng
  text: We consider finite-volume approximations of Fokker-Planck equations on bounded
    convex domains in R^d and study the corresponding gradient flow structures. We
    reprove the convergence of the discrete to continuous Fokker-Planck equation via
    the method of Evolutionary Γ-convergence, i.e., we pass to the limit at the level
    of the gradient flow structures, generalising the one-dimensional result obtained
    by Disser and Liero. The proof is of variational nature and relies on a Mosco
    convergence result for functionals in the discrete-to-continuum limit that is
    of independent interest. Our results apply to arbitrary regular meshes, even though
    the associated discrete transport distances may fail to converge to the Wasserstein
    distance in this generality.
acknowledgement: This work is supported by the European Research Council (ERC) under
  the European Union’s Horizon 2020 research and innovation programme (grant agreement
  No 716117) and by the Austrian Science Fund (FWF), grants No F65 and W1245.
article_number: '2008.10962'
article_processing_charge: No
arxiv: 1
author:
- first_name: Dominik L
  full_name: Forkert, Dominik L
  id: 35C79D68-F248-11E8-B48F-1D18A9856A87
  last_name: Forkert
- first_name: Jan
  full_name: Maas, Jan
  id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
  last_name: Maas
  orcid: 0000-0002-0845-1338
- first_name: Lorenzo
  full_name: Portinale, Lorenzo
  id: 30AD2CBC-F248-11E8-B48F-1D18A9856A87
  last_name: Portinale
citation:
  ama: Forkert DL, Maas J, Portinale L. Evolutionary Γ-convergence of entropic gradient
    flow structures for Fokker-Planck equations in multiple dimensions. <i>arXiv</i>.
    doi:<a href="https://doi.org/10.48550/arXiv.2008.10962">10.48550/arXiv.2008.10962</a>
  apa: Forkert, D. L., Maas, J., &#38; Portinale, L. (n.d.). Evolutionary Γ-convergence
    of entropic gradient flow structures for Fokker-Planck equations in multiple dimensions.
    <i>arXiv</i>. <a href="https://doi.org/10.48550/arXiv.2008.10962">https://doi.org/10.48550/arXiv.2008.10962</a>
  chicago: Forkert, Dominik L, Jan Maas, and Lorenzo Portinale. “Evolutionary Γ-Convergence
    of Entropic Gradient Flow Structures for Fokker-Planck Equations in Multiple Dimensions.”
    <i>ArXiv</i>, n.d. <a href="https://doi.org/10.48550/arXiv.2008.10962">https://doi.org/10.48550/arXiv.2008.10962</a>.
  ieee: D. L. Forkert, J. Maas, and L. Portinale, “Evolutionary Γ-convergence of entropic
    gradient flow structures for Fokker-Planck equations in multiple dimensions,”
    <i>arXiv</i>. .
  ista: Forkert DL, Maas J, Portinale L. Evolutionary Γ-convergence of entropic gradient
    flow structures for Fokker-Planck equations in multiple dimensions. arXiv, 2008.10962.
  mla: Forkert, Dominik L., et al. “Evolutionary Γ-Convergence of Entropic Gradient
    Flow Structures for Fokker-Planck Equations in Multiple Dimensions.” <i>ArXiv</i>,
    2008.10962, doi:<a href="https://doi.org/10.48550/arXiv.2008.10962">10.48550/arXiv.2008.10962</a>.
  short: D.L. Forkert, J. Maas, L. Portinale, ArXiv (n.d.).
corr_author: '1'
date_created: 2021-09-17T10:57:27Z
date_published: 2020-08-25T00:00:00Z
date_updated: 2026-04-08T07:00:03Z
day: '25'
department:
- _id: JaMa
doi: 10.48550/arXiv.2008.10962
ec_funded: 1
external_id:
  arxiv:
  - '2008.10962'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2008.10962
month: '08'
oa: 1
oa_version: Preprint
project:
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '716117'
  name: Optimal Transport and Stochastic Dynamics
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
  grant_number: F6504
  name: Taming Complexity in Partial Differential Systems
publication: arXiv
publication_status: draft
related_material:
  record:
  - id: '11739'
    relation: later_version
    status: public
  - id: '10030'
    relation: dissertation_contains
    status: public
status: public
title: Evolutionary Γ-convergence of entropic gradient flow structures for Fokker-Planck
  equations in multiple dimensions
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '10336'
abstract:
- lang: eng
  text: Biological membranes can dramatically accelerate the aggregation of normally
    soluble protein molecules into amyloid fibrils and alter the fibril morphologies,
    yet the molecular mechanisms through which this accelerated nucleation takes place
    are not yet understood. Here, we develop a coarse-grained model to systematically
    explore the effect that the structural properties of the lipid membrane and the
    nature of protein–membrane interactions have on the nucleation rates of amyloid
    fibrils. We identify two physically distinct nucleation pathways—protein-rich
    and lipid-rich—and quantify how the membrane fluidity and protein–membrane affinity
    control the relative importance of those molecular pathways. We find that the
    membrane’s susceptibility to reshaping and being incorporated into the fibrillar
    aggregates is a key determinant of its ability to promote protein aggregation.
    We then characterize the rates and the free-energy profile associated with this
    heterogeneous nucleation process, in which the surface itself participates in
    the aggregate structure. Finally, we compare quantitatively our data to experiments
    on membrane-catalyzed amyloid aggregation of α-synuclein, a protein implicated
    in Parkinson’s disease that predominately nucleates on membranes. More generally,
    our results provide a framework for understanding macromolecular aggregation on
    lipid membranes in a broad biological and biotechnological context.
acknowledgement: We thank T. C. T. Michaels for reading the manuscript. This work
  was supported by the Academy of Medical Science (J.K. and A.Š.), the Cambridge Center
  for Misfolding Diseases (T.P.J.K.), the Biotechnology and Biological Sciences Research
  Council (T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.), the European
  Research Council Grant PhysProt Agreement 337969, the Wellcome Trust (A.Š. and T.P.J.K.),
  the Royal Society (A.Š.), the Medical Research Council (J.K. and A.Š.), and the
  UK Materials and Molecular Modeling Hub for computational resources, which is partially
  funded by Engineering and Physical Sciences Research Council Grant EP/P020194/1.
article_processing_charge: No
article_type: original
author:
- first_name: Johannes
  full_name: Krausser, Johannes
  last_name: Krausser
- first_name: Tuomas P. J.
  full_name: Knowles, Tuomas P. J.
  last_name: Knowles
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
citation:
  ama: Krausser J, Knowles TPJ, Šarić A. Physical mechanisms of amyloid nucleation
    on fluid membranes. <i>Proceedings of the National Academy of Sciences</i>. 2020;117(52):33090-33098.
    doi:<a href="https://doi.org/10.1073/pnas.2007694117">10.1073/pnas.2007694117</a>
  apa: Krausser, J., Knowles, T. P. J., &#38; Šarić, A. (2020). Physical mechanisms
    of amyloid nucleation on fluid membranes. <i>Proceedings of the National Academy
    of Sciences</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.2007694117">https://doi.org/10.1073/pnas.2007694117</a>
  chicago: Krausser, Johannes, Tuomas P. J. Knowles, and Anđela Šarić. “Physical Mechanisms
    of Amyloid Nucleation on Fluid Membranes.” <i>Proceedings of the National Academy
    of Sciences</i>. National Academy of Sciences, 2020. <a href="https://doi.org/10.1073/pnas.2007694117">https://doi.org/10.1073/pnas.2007694117</a>.
  ieee: J. Krausser, T. P. J. Knowles, and A. Šarić, “Physical mechanisms of amyloid
    nucleation on fluid membranes,” <i>Proceedings of the National Academy of Sciences</i>,
    vol. 117, no. 52. National Academy of Sciences, pp. 33090–33098, 2020.
  ista: Krausser J, Knowles TPJ, Šarić A. 2020. Physical mechanisms of amyloid nucleation
    on fluid membranes. Proceedings of the National Academy of Sciences. 117(52),
    33090–33098.
  mla: Krausser, Johannes, et al. “Physical Mechanisms of Amyloid Nucleation on Fluid
    Membranes.” <i>Proceedings of the National Academy of Sciences</i>, vol. 117,
    no. 52, National Academy of Sciences, 2020, pp. 33090–98, doi:<a href="https://doi.org/10.1073/pnas.2007694117">10.1073/pnas.2007694117</a>.
  short: J. Krausser, T.P.J. Knowles, A. Šarić, Proceedings of the National Academy
    of Sciences 117 (2020) 33090–33098.
date_created: 2021-11-25T15:07:09Z
date_published: 2020-12-16T00:00:00Z
date_updated: 2021-11-25T15:35:58Z
day: '16'
doi: 10.1073/pnas.2007694117
extern: '1'
external_id:
  pmid:
  - '33328273'
intvolume: '       117'
issue: '52'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/2019.12.22.886267v2
month: '12'
oa: 1
oa_version: Published Version
page: 33090-33098
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
  eissn:
  - 1091-6490
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Physical mechanisms of amyloid nucleation on fluid membranes
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 117
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
_id: '10341'
abstract:
- lang: eng
  text: Tracing the motion of macromolecules, viruses, and nanoparticles adsorbed
    onto cell membranes is currently the most direct way of probing the complex dynamic
    interactions behind vital biological processes, including cell signalling, trafficking,
    and viral infection. The resulting trajectories are usually consistent with some
    type of anomalous diffusion, but the molecular origins behind the observed anomalous
    behaviour are usually not obvious. Here we use coarse-grained molecular dynamics
    simulations to help identify the physical mechanisms that can give rise to experimentally
    observed trajectories of nanoscopic objects moving on biological membranes. We
    find that diffusion on membranes of high fluidities typically results in normal
    diffusion of the adsorbed nanoparticle, irrespective of the concentration of receptors,
    receptor clustering, or multivalent interactions between the particle and membrane
    receptors. Gel-like membranes on the other hand result in anomalous diffusion
    of the particle, which becomes more pronounced at higher receptor concentrations.
    This anomalous diffusion is characterised by local particle trapping in the regions
    of high receptor concentrations and fast hopping between such regions. The normal
    diffusion is recovered in the limit where the gel membrane is saturated with receptors.
    We conclude that hindered receptor diffusivity can be a common reason behind the
    observed anomalous diffusion of viruses, vesicles, and nanoparticles adsorbed
    on cell and model membranes. Our results enable direct comparison with experiments
    and offer a new route for interpreting motility experiments on cell membranes.
acknowledgement: We thank Jessica McQuade for her input at the start of the project.
  We acknowledge support from the ERASMUS Placement Programme (V. E. D.), the UCL
  Institute for the Physics of Living Systems (V. E. D. and A. Š.), the UCL Global
  Engagement Fund (L. M. C. J.), and the Royal Society (A. Š.).
article_processing_charge: No
article_type: original
author:
- first_name: V. E.
  full_name: Debets, V. E.
  last_name: Debets
- first_name: L. M. C.
  full_name: Janssen, L. M. C.
  last_name: Janssen
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
citation:
  ama: Debets VE, Janssen LMC, Šarić A. Characterising the diffusion of biological
    nanoparticles on fluid and cross-linked membranes. <i>Soft Matter</i>. 2020;16(47):10628-10639.
    doi:<a href="https://doi.org/10.1039/d0sm00712a">10.1039/d0sm00712a</a>
  apa: Debets, V. E., Janssen, L. M. C., &#38; Šarić, A. (2020). Characterising the
    diffusion of biological nanoparticles on fluid and cross-linked membranes. <i>Soft
    Matter</i>. Royal Society of Chemistry. <a href="https://doi.org/10.1039/d0sm00712a">https://doi.org/10.1039/d0sm00712a</a>
  chicago: Debets, V. E., L. M. C. Janssen, and Anđela Šarić. “Characterising the
    Diffusion of Biological Nanoparticles on Fluid and Cross-Linked Membranes.” <i>Soft
    Matter</i>. Royal Society of Chemistry, 2020. <a href="https://doi.org/10.1039/d0sm00712a">https://doi.org/10.1039/d0sm00712a</a>.
  ieee: V. E. Debets, L. M. C. Janssen, and A. Šarić, “Characterising the diffusion
    of biological nanoparticles on fluid and cross-linked membranes,” <i>Soft Matter</i>,
    vol. 16, no. 47. Royal Society of Chemistry, pp. 10628–10639, 2020.
  ista: Debets VE, Janssen LMC, Šarić A. 2020. Characterising the diffusion of biological
    nanoparticles on fluid and cross-linked membranes. Soft Matter. 16(47), 10628–10639.
  mla: Debets, V. E., et al. “Characterising the Diffusion of Biological Nanoparticles
    on Fluid and Cross-Linked Membranes.” <i>Soft Matter</i>, vol. 16, no. 47, Royal
    Society of Chemistry, 2020, pp. 10628–39, doi:<a href="https://doi.org/10.1039/d0sm00712a">10.1039/d0sm00712a</a>.
  short: V.E. Debets, L.M.C. Janssen, A. Šarić, Soft Matter 16 (2020) 10628–10639.
date_created: 2021-11-26T06:29:41Z
date_published: 2020-10-06T00:00:00Z
date_updated: 2024-10-16T12:53:17Z
day: '06'
doi: 10.1039/d0sm00712a
extern: '1'
external_id:
  pmid:
  - '33084724'
intvolume: '        16'
issue: '47'
keyword:
- condensed matter physics
- general chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/2020.05.01.071761v1
month: '10'
oa: 1
oa_version: Published Version
page: 10628-10639
pmid: 1
publication: Soft Matter
publication_identifier:
  issn:
  - 1744-683X
  - 1744-6848
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Characterising the diffusion of biological nanoparticles on fluid and cross-linked
  membranes
type: journal_article
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
volume: 16
year: '2020'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '10342'
abstract:
- lang: eng
  text: The blood-brain barrier is made of polarized brain endothelial cells (BECs)
    phenotypically conditioned by the central nervous system (CNS). Although transport
    across BECs is of paramount importance for nutrient uptake as well as ridding
    the brain of waste products, the intracellular sorting mechanisms that regulate
    successful receptor-mediated transcytosis in BECs remain to be elucidated. Here,
    we used a synthetic multivalent system with tunable avidity to the low-density
    lipoprotein receptor–related protein 1 (LRP1) to investigate the mechanisms of
    transport across BECs. We used a combination of conventional and super-resolution
    microscopy, both in vivo and in vitro, accompanied with biophysical modeling of
    transport kinetics and membrane-bound interactions to elucidate the role of membrane-sculpting
    protein syndapin-2 on fast transport via tubule formation. We show that high-avidity
    cargo biases the LRP1 toward internalization associated with fast degradation,
    while mid-avidity augments the formation of syndapin-2 tubular carriers promoting
    a fast shuttling across.
acknowledgement: 'Funding: G.B. thanks the ERC for the starting grant (MEViC 278793)
  and consolidator award (CheSSTaG 769798), EPSRC/BTG Healthcare Partnership (EP/I001697/1),
  EPSRC Established Career Fellowship (EP/N026322/1), EPSRC/SomaNautix Healthcare
  Partnership EP/R024723/1, and Children with Cancer UK for the research project (16-227).
  X.T. and G.B. thank that Anhui 100 Talent program for facilitating data sharing
  and research visits. A.D.-C. and L.R. acknowledge the Royal Society for a Newton
  fellowship and the Marie Skłodowska-Curie Actions for a European Fellowship. Author
  contributions: X.T. prepared and characterized POs, performed all the fast imaging
  in both conventional and STED microscopy, set up the initial BBB model, encapsulated
  the PtA2 in POs, and supervised the PtA2-PO animal work. D.M.L. prepared and characterized
  POs; performed all the permeability studies, PLA assays, WB and associated data
  analysis, and part of the colocalization assays; and performed experiments with
  the shRNA for knockdown of syndapin-2. E.S. prepared and characterized POs and performed
  part of colocalization assays and Cy7-labeled PO animal experiments. S.N. prepared
  and characterized POs and performed part of the colocalization and inhibition assays.
  G.F. designed, performed, and analyzed the agent-based simulations of transcytosis.
  J.F. designed the image-based algorithm to analyze the PLA data. D.M. prepared and
  characterized POs and helped with Cy7-labeled PO animal experiments. A.A. performed
  TEM imaging of the POs. A.P. and A.D.-C. synthesized the dye- and peptide-functionalized
  and pristine copolymers. M.V., L.H.-K., and A.Š. designed, performed, and analyzed
  the MD simulations. Z.Z. supervised and supported STED imaging. P.X., B.F., and
  Y.T. synthesized and characterized the PtA2 compound. L.L. performed some of the
  animal work. L.R. supported and helped with the BBB characterization. G.B. analyzed
  all fast imaging and supervised and coordinated the overall work. X.T., D.M.L.,
  E.S., and G.B. wrote the manuscript. Competing interests: The authors declare that
  part of the work is associated with the UCL spin-out company SomaNautix Ltd. Data
  and materials availability: All data needed to evaluate the conclusions in the paper
  are present in the paper and/or the Supplementary Materials. Additional data related
  to this paper may be requested from the authors.'
article_number: 'eabc4397 '
article_processing_charge: No
article_type: original
author:
- first_name: Xiaohe
  full_name: Tian, Xiaohe
  last_name: Tian
- first_name: Diana M.
  full_name: Leite, Diana M.
  last_name: Leite
- first_name: Edoardo
  full_name: Scarpa, Edoardo
  last_name: Scarpa
- first_name: Sophie
  full_name: Nyberg, Sophie
  last_name: Nyberg
- first_name: Gavin
  full_name: Fullstone, Gavin
  last_name: Fullstone
- first_name: Joe
  full_name: Forth, Joe
  last_name: Forth
- first_name: Diana
  full_name: Matias, Diana
  last_name: Matias
- first_name: Azzurra
  full_name: Apriceno, Azzurra
  last_name: Apriceno
- first_name: Alessandro
  full_name: Poma, Alessandro
  last_name: Poma
- first_name: Aroa
  full_name: Duro-Castano, Aroa
  last_name: Duro-Castano
- first_name: Manish
  full_name: Vuyyuru, Manish
  last_name: Vuyyuru
- first_name: Lena
  full_name: Harker-Kirschneck, Lena
  last_name: Harker-Kirschneck
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Zhongping
  full_name: Zhang, Zhongping
  last_name: Zhang
- first_name: Pan
  full_name: Xiang, Pan
  last_name: Xiang
- first_name: Bin
  full_name: Fang, Bin
  last_name: Fang
- first_name: Yupeng
  full_name: Tian, Yupeng
  last_name: Tian
- first_name: Lei
  full_name: Luo, Lei
  last_name: Luo
- first_name: Loris
  full_name: Rizzello, Loris
  last_name: Rizzello
- first_name: Giuseppe
  full_name: Battaglia, Giuseppe
  last_name: Battaglia
citation:
  ama: 'Tian X, Leite DM, Scarpa E, et al. On the shuttling across the blood-brain
    barrier via tubule formation: Mechanism and cargo avidity bias. <i>Science Advances</i>.
    2020;6(48). doi:<a href="https://doi.org/10.1126/sciadv.abc4397">10.1126/sciadv.abc4397</a>'
  apa: 'Tian, X., Leite, D. M., Scarpa, E., Nyberg, S., Fullstone, G., Forth, J.,
    … Battaglia, G. (2020). On the shuttling across the blood-brain barrier via tubule
    formation: Mechanism and cargo avidity bias. <i>Science Advances</i>. American
    Association for the Advancement of Science. <a href="https://doi.org/10.1126/sciadv.abc4397">https://doi.org/10.1126/sciadv.abc4397</a>'
  chicago: 'Tian, Xiaohe, Diana M. Leite, Edoardo Scarpa, Sophie Nyberg, Gavin Fullstone,
    Joe Forth, Diana Matias, et al. “On the Shuttling across the Blood-Brain Barrier
    via Tubule Formation: Mechanism and Cargo Avidity Bias.” <i>Science Advances</i>.
    American Association for the Advancement of Science, 2020. <a href="https://doi.org/10.1126/sciadv.abc4397">https://doi.org/10.1126/sciadv.abc4397</a>.'
  ieee: 'X. Tian <i>et al.</i>, “On the shuttling across the blood-brain barrier via
    tubule formation: Mechanism and cargo avidity bias,” <i>Science Advances</i>,
    vol. 6, no. 48. American Association for the Advancement of Science, 2020.'
  ista: 'Tian X, Leite DM, Scarpa E, Nyberg S, Fullstone G, Forth J, Matias D, Apriceno
    A, Poma A, Duro-Castano A, Vuyyuru M, Harker-Kirschneck L, Šarić A, Zhang Z, Xiang
    P, Fang B, Tian Y, Luo L, Rizzello L, Battaglia G. 2020. On the shuttling across
    the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias.
    Science Advances. 6(48), eabc4397.'
  mla: 'Tian, Xiaohe, et al. “On the Shuttling across the Blood-Brain Barrier via
    Tubule Formation: Mechanism and Cargo Avidity Bias.” <i>Science Advances</i>,
    vol. 6, no. 48, eabc4397, American Association for the Advancement of Science,
    2020, doi:<a href="https://doi.org/10.1126/sciadv.abc4397">10.1126/sciadv.abc4397</a>.'
  short: X. Tian, D.M. Leite, E. Scarpa, S. Nyberg, G. Fullstone, J. Forth, D. Matias,
    A. Apriceno, A. Poma, A. Duro-Castano, M. Vuyyuru, L. Harker-Kirschneck, A. Šarić,
    Z. Zhang, P. Xiang, B. Fang, Y. Tian, L. Luo, L. Rizzello, G. Battaglia, Science
    Advances 6 (2020).
date_created: 2021-11-26T06:40:28Z
date_published: 2020-11-27T00:00:00Z
date_updated: 2024-10-16T12:56:52Z
day: '27'
ddc:
- '611'
doi: 10.1126/sciadv.abc4397
extern: '1'
external_id:
  pmid:
  - '33246953'
file:
- access_level: open_access
  checksum: 3ba2eca975930cdb0b1ce1ae876885a7
  content_type: application/pdf
  creator: cchlebak
  date_created: 2021-11-26T06:50:09Z
  date_updated: 2021-11-26T06:50:09Z
  file_id: '10343'
  file_name: 2020_SciAdv_Tian.pdf
  file_size: 10381298
  relation: main_file
  success: 1
file_date_updated: 2021-11-26T06:50:09Z
has_accepted_license: '1'
intvolume: '         6'
issue: '48'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/2020.04.04.025866v1
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
  issn:
  - 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'On the shuttling across the blood-brain barrier via tubule formation: Mechanism
  and cargo avidity bias'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
volume: 6
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
_id: '10344'
abstract:
- lang: eng
  text: In this study, we investigate the role of the surface patterning of nanostructures
    for cell membrane reshaping. To accomplish this, we combine an evolutionary algorithm
    with coarse-grained molecular dynamics simulations and explore the solution space
    of ligand patterns on a nanoparticle that promote efficient and reliable cell
    uptake. Surprisingly, we find that in the regime of low ligand number the best-performing
    structures are characterized by ligands arranged into long one-dimensional chains
    that pattern the surface of the particle. We show that these chains of ligands
    provide particles with high rotational freedom and they lower the free energy
    barrier for membrane crossing. Our approach reveals a set of nonintuitive design
    rules that can be used to inform artificial nanoparticle construction and the
    search for inhibitors of viral entry.
acknowledgement: We acknowledge support from EPSRC (J. C. F.), MRC (B. B. and A. Š.),
  the ERC StG 802960 “NEPA” (J. K. and A. Š.), the Royal Society (A. Š.), and the
  United Kingdom Materials and Molecular Modelling Hub for computational resources,
  which is partially funded by EPSRC (EP/P020194/1).
article_number: '228101'
article_processing_charge: No
article_type: original
author:
- first_name: Joel C.
  full_name: Forster, Joel C.
  last_name: Forster
- first_name: Johannes
  full_name: Krausser, Johannes
  last_name: Krausser
- first_name: Manish R.
  full_name: Vuyyuru, Manish R.
  last_name: Vuyyuru
- first_name: Buzz
  full_name: Baum, Buzz
  last_name: Baum
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
citation:
  ama: Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. Exploring the design rules
    for efficient membrane-reshaping nanostructures. <i>Physical Review Letters</i>.
    2020;125(22). doi:<a href="https://doi.org/10.1103/physrevlett.125.228101">10.1103/physrevlett.125.228101</a>
  apa: Forster, J. C., Krausser, J., Vuyyuru, M. R., Baum, B., &#38; Šarić, A. (2020).
    Exploring the design rules for efficient membrane-reshaping nanostructures. <i>Physical
    Review Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/physrevlett.125.228101">https://doi.org/10.1103/physrevlett.125.228101</a>
  chicago: Forster, Joel C., Johannes Krausser, Manish R. Vuyyuru, Buzz Baum, and
    Anđela Šarić. “Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures.”
    <i>Physical Review Letters</i>. American Physical Society, 2020. <a href="https://doi.org/10.1103/physrevlett.125.228101">https://doi.org/10.1103/physrevlett.125.228101</a>.
  ieee: J. C. Forster, J. Krausser, M. R. Vuyyuru, B. Baum, and A. Šarić, “Exploring
    the design rules for efficient membrane-reshaping nanostructures,” <i>Physical
    Review Letters</i>, vol. 125, no. 22. American Physical Society, 2020.
  ista: Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. 2020. Exploring the design
    rules for efficient membrane-reshaping nanostructures. Physical Review Letters.
    125(22), 228101.
  mla: Forster, Joel C., et al. “Exploring the Design Rules for Efficient Membrane-Reshaping
    Nanostructures.” <i>Physical Review Letters</i>, vol. 125, no. 22, 228101, American
    Physical Society, 2020, doi:<a href="https://doi.org/10.1103/physrevlett.125.228101">10.1103/physrevlett.125.228101</a>.
  short: J.C. Forster, J. Krausser, M.R. Vuyyuru, B. Baum, A. Šarić, Physical Review
    Letters 125 (2020).
date_created: 2021-11-26T07:10:43Z
date_published: 2020-11-23T00:00:00Z
date_updated: 2024-10-16T12:59:57Z
day: '23'
ddc:
- '530'
doi: 10.1103/physrevlett.125.228101
extern: '1'
external_id:
  pmid:
  - '33315453'
file:
- access_level: open_access
  checksum: fbf2e1415e332d6add90222d60401a1d
  content_type: application/pdf
  creator: cchlebak
  date_created: 2021-11-26T07:16:49Z
  date_updated: 2021-11-26T07:16:49Z
  file_id: '10345'
  file_name: 2020_PhysRevLett_Forster.pdf
  file_size: 844353
  relation: main_file
  success: 1
file_date_updated: 2021-11-26T07:16:49Z
has_accepted_license: '1'
intvolume: '       125'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/2020.02.27.968149v1
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Exploring the design rules for efficient membrane-reshaping nanostructures
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
volume: 125
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
_id: '10346'
abstract:
- lang: eng
  text: One of the most robust examples of self-assembly in living organisms is the
    formation of collagen architectures. Collagen type I molecules are a crucial component
    of the extracellular matrix, where they self-assemble into fibrils of well-defined
    axial striped patterns. This striped fibrillar pattern is preserved across the
    animal kingdom and is important for the determination of cell phenotype, cell
    adhesion, and tissue regulation and signaling. The understanding of the physical
    processes that determine such a robust morphology of self-assembled collagen fibrils
    is currently almost completely missing. Here, we develop a minimal coarse-grained
    computational model to identify the physical principles of the assembly of collagen-mimetic
    molecules. We find that screened electrostatic interactions can drive the formation
    of collagen-like filaments of well-defined striped morphologies. The fibril axial
    pattern is determined solely by the distribution of charges on the molecule and
    is robust to the changes in protein concentration, monomer rigidity, and environmental
    conditions. We show that the striped fibrillar pattern cannot be easily predicted
    from the interactions between two monomers but is an emergent result of multibody
    interactions. Our results can help address collagen remodeling in diseases and
    aging and guide the design of collagen scaffolds for biotechnological applications.
acknowledgement: We thank Melinda Duer, Patrick Mesquida, Lucy Colwell, Lucie Liu,
  Daan Frenkel, and Ivan Palaia for helpful discussions. We acknowledge support from
  the Engineering and Physical Sciences Research Council (A.E.H., L.K.D., and A.Š.),
  Biotechnology and Biological Sciences Research Council LIDo programme (N.G.G. and
  C.A.B.), the Royal Society (A.Š.), and the UK Materials and Molecular Modelling
  Hub for computational resources, which is partially funded by EPSRC ( EP/P020194/1).
article_processing_charge: No
article_type: original
author:
- first_name: Anne E.
  full_name: Hafner, Anne E.
  last_name: Hafner
- first_name: Noemi G.
  full_name: Gyori, Noemi G.
  last_name: Gyori
- first_name: Ciaran A.
  full_name: Bench, Ciaran A.
  last_name: Bench
- first_name: Luke K.
  full_name: Davis, Luke K.
  last_name: Davis
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
citation:
  ama: Hafner AE, Gyori NG, Bench CA, Davis LK, Šarić A. Modeling fibrillogenesis
    of collagen-mimetic molecules. <i>Biophysical Journal</i>. 2020;119(9):1791-1799.
    doi:<a href="https://doi.org/10.1016/j.bpj.2020.09.013">10.1016/j.bpj.2020.09.013</a>
  apa: Hafner, A. E., Gyori, N. G., Bench, C. A., Davis, L. K., &#38; Šarić, A. (2020).
    Modeling fibrillogenesis of collagen-mimetic molecules. <i>Biophysical Journal</i>.
    Cell Press. <a href="https://doi.org/10.1016/j.bpj.2020.09.013">https://doi.org/10.1016/j.bpj.2020.09.013</a>
  chicago: Hafner, Anne E., Noemi G. Gyori, Ciaran A. Bench, Luke K. Davis, and Anđela
    Šarić. “Modeling Fibrillogenesis of Collagen-Mimetic Molecules.” <i>Biophysical
    Journal</i>. Cell Press, 2020. <a href="https://doi.org/10.1016/j.bpj.2020.09.013">https://doi.org/10.1016/j.bpj.2020.09.013</a>.
  ieee: A. E. Hafner, N. G. Gyori, C. A. Bench, L. K. Davis, and A. Šarić, “Modeling
    fibrillogenesis of collagen-mimetic molecules,” <i>Biophysical Journal</i>, vol.
    119, no. 9. Cell Press, pp. 1791–1799, 2020.
  ista: Hafner AE, Gyori NG, Bench CA, Davis LK, Šarić A. 2020. Modeling fibrillogenesis
    of collagen-mimetic molecules. Biophysical Journal. 119(9), 1791–1799.
  mla: Hafner, Anne E., et al. “Modeling Fibrillogenesis of Collagen-Mimetic Molecules.”
    <i>Biophysical Journal</i>, vol. 119, no. 9, Cell Press, 2020, pp. 1791–99, doi:<a
    href="https://doi.org/10.1016/j.bpj.2020.09.013">10.1016/j.bpj.2020.09.013</a>.
  short: A.E. Hafner, N.G. Gyori, C.A. Bench, L.K. Davis, A. Šarić, Biophysical Journal
    119 (2020) 1791–1799.
date_created: 2021-11-26T07:27:24Z
date_published: 2020-09-23T00:00:00Z
date_updated: 2024-10-16T13:05:34Z
day: '23'
doi: 10.1016/j.bpj.2020.09.013
extern: '1'
external_id:
  pmid:
  - '33049216'
intvolume: '       119'
issue: '9'
keyword:
- biophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/2020.06.08.140061v1
month: '09'
oa: 1
oa_version: Published Version
page: 1791-1799
pmid: 1
publication: Biophysical Journal
publication_identifier:
  issn:
  - 0006-3495
publication_status: published
publisher: Cell Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modeling fibrillogenesis of collagen-mimetic molecules
type: journal_article
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
volume: 119
year: '2020'
...
---
_id: '10347'
abstract:
- lang: eng
  text: Understanding the mechanism of action of compounds capable of inhibiting amyloid-fibril
    formation is critical to the development of potential therapeutics against protein-misfolding
    diseases. A fundamental challenge for progress is the range of possible target
    species and the disparate timescales involved, since the aggregating proteins
    are simultaneously the reactants, products, intermediates, and catalysts of the
    reaction. It is a complex problem, therefore, to choose the states of the aggregating
    proteins that should be bound by the compounds to achieve the most potent inhibition.
    We present here a comprehensive kinetic theory of amyloid-aggregation inhibition
    that reveals the fundamental thermodynamic and kinetic signatures characterizing
    effective inhibitors by identifying quantitative relationships between the aggregation
    and binding rate constants. These results provide general physical laws to guide
    the design and optimization of inhibitors of amyloid-fibril formation, revealing
    in particular the important role of on-rates in the binding of the inhibitors.
acknowledgement: We acknowledge support from Peterhouse, Cambridge (T.C.T.M.); the
  Swiss National Science Foundation (T.C.T.M.); the Royal Society (A.S. and S.C.);
  the Academy of Medical Sciences (A.S.); Sidney Sussex College, Cambridge (G.M.);
  Newnham College, Cambridge (G.T.H.); the Wellcome Trust (T.P.J.K.); the Cambridge
  Center for Misfolding Diseases (T.P.J.K. and M.V.); the Biotechnology and Biological
  Sciences Research Council (T.P.J.K.); the Frances and Augustus Newman Foundation
  (T.P.J.K.); and the Synapsis Foundation for Alzheimer’s disease (P.A.). The research
  leading to these results has received funding from the European Research Council
  (ERC) under the European Union’s Seventh Framework Program (FP7/2007-2013) through
  the ERC Grant PhysProt (Agreement 337969).
article_processing_charge: No
article_type: original
author:
- first_name: Thomas C. T.
  full_name: Michaels, Thomas C. T.
  last_name: Michaels
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Georg
  full_name: Meisl, Georg
  last_name: Meisl
- first_name: Gabriella T.
  full_name: Heller, Gabriella T.
  last_name: Heller
- first_name: Samo
  full_name: Curk, Samo
  last_name: Curk
- first_name: Paolo
  full_name: Arosio, Paolo
  last_name: Arosio
- first_name: Sara
  full_name: Linse, Sara
  last_name: Linse
- first_name: Christopher M.
  full_name: Dobson, Christopher M.
  last_name: Dobson
- first_name: Michele
  full_name: Vendruscolo, Michele
  last_name: Vendruscolo
- first_name: Tuomas P. J.
  full_name: Knowles, Tuomas P. J.
  last_name: Knowles
citation:
  ama: Michaels TCT, Šarić A, Meisl G, et al. Thermodynamic and kinetic design principles
    for amyloid-aggregation inhibitors. <i>Proceedings of the National Academy of
    Sciences</i>. 2020;117(39):24251-24257. doi:<a href="https://doi.org/10.1073/pnas.2006684117">10.1073/pnas.2006684117</a>
  apa: Michaels, T. C. T., Šarić, A., Meisl, G., Heller, G. T., Curk, S., Arosio,
    P., … Knowles, T. P. J. (2020). Thermodynamic and kinetic design principles for
    amyloid-aggregation inhibitors. <i>Proceedings of the National Academy of Sciences</i>.
    National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.2006684117">https://doi.org/10.1073/pnas.2006684117</a>
  chicago: Michaels, Thomas C. T., Anđela Šarić, Georg Meisl, Gabriella T. Heller,
    Samo Curk, Paolo Arosio, Sara Linse, Christopher M. Dobson, Michele Vendruscolo,
    and Tuomas P. J. Knowles. “Thermodynamic and Kinetic Design Principles for Amyloid-Aggregation
    Inhibitors.” <i>Proceedings of the National Academy of Sciences</i>. National
    Academy of Sciences, 2020. <a href="https://doi.org/10.1073/pnas.2006684117">https://doi.org/10.1073/pnas.2006684117</a>.
  ieee: T. C. T. Michaels <i>et al.</i>, “Thermodynamic and kinetic design principles
    for amyloid-aggregation inhibitors,” <i>Proceedings of the National Academy of
    Sciences</i>, vol. 117, no. 39. National Academy of Sciences, pp. 24251–24257,
    2020.
  ista: Michaels TCT, Šarić A, Meisl G, Heller GT, Curk S, Arosio P, Linse S, Dobson
    CM, Vendruscolo M, Knowles TPJ. 2020. Thermodynamic and kinetic design principles
    for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences.
    117(39), 24251–24257.
  mla: Michaels, Thomas C. T., et al. “Thermodynamic and Kinetic Design Principles
    for Amyloid-Aggregation Inhibitors.” <i>Proceedings of the National Academy of
    Sciences</i>, vol. 117, no. 39, National Academy of Sciences, 2020, pp. 24251–57,
    doi:<a href="https://doi.org/10.1073/pnas.2006684117">10.1073/pnas.2006684117</a>.
  short: T.C.T. Michaels, A. Šarić, G. Meisl, G.T. Heller, S. Curk, P. Arosio, S.
    Linse, C.M. Dobson, M. Vendruscolo, T.P.J. Knowles, Proceedings of the National
    Academy of Sciences 117 (2020) 24251–24257.
date_created: 2021-11-26T07:48:27Z
date_published: 2020-09-14T00:00:00Z
date_updated: 2021-11-26T08:59:06Z
day: '14'
doi: 10.1073/pnas.2006684117
extern: '1'
external_id:
  pmid:
  - '32929030'
intvolume: '       117'
issue: '39'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/2020.02.22.960716
month: '09'
oa: 1
oa_version: Published Version
page: 24251-24257
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
  eissn:
  - 1091-6490
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 117
year: '2020'
...
---
_id: '10348'
abstract:
- lang: eng
  text: The endosomal sorting complex required for transport-III (ESCRT-III) catalyzes
    membrane fission from within membrane necks, a process that is essential for many
    cellular functions, from cell division to lysosome degradation and autophagy.
    How it breaks membranes, though, remains unknown. Here, we characterize a sequential
    polymerization of ESCRT-III subunits that, driven by a recruitment cascade and
    by continuous subunit-turnover powered by the ATPase Vps4, induces membrane deformation
    and fission. During this process, the exchange of Vps24 for Did2 induces a tilt
    in the polymer-membrane interface, which triggers transition from flat spiral
    polymers to helical filament to drive the formation of membrane protrusions, and
    ends with the formation of a highly constricted Did2-Ist1 co-polymer that we show
    is competent to promote fission when bound on the inside of membrane necks. Overall,
    our results suggest a mechanism of stepwise changes in ESCRT-III filament structure
    and mechanical properties via exchange of the filament subunits to catalyze ESCRT-III
    activity.
acknowledgement: The authors thank Nicolas Chiaruttini, Jean Gruenberg, and Lena Harker-Kirschneck
  for careful correction of this manuscript and helpful discussions. The authors want
  to thank the NCCR Chemical Biology for constant support during this project. A.R.
  acknowledges funding from the Swiss National Fund for Research (31003A_130520, 31003A_149975,
  and 31003A_173087) and the European Research Council Consolidator (311536). A.Š.
  acknowledges the European Research Council (802960). B.B. thanks the BBSRC (BB/K009001/1)
  and Wellcome Trust (203276/Z/16/Z) for support. J.M.v.F. acknowledges funding through
  an EMBO Long-Term Fellowship (ALTF 1065-2015), the European Commission FP7 (Marie
  Curie Actions, LTFCOFUND2013, and GA-2013-609409), and a Transitional Postdoc fellowship
  (2015/345) from the Swiss SystemsX.ch initiative, evaluated by the Swiss National
  Science Foundation and Swiss National Science Foundation Research (SNSF SINERGIA
  160728/1 [leader, Sophie Martin]).
article_processing_charge: No
article_type: original
author:
- first_name: Anna-Katharina
  full_name: Pfitzner, Anna-Katharina
  last_name: Pfitzner
- first_name: Vincent
  full_name: Mercier, Vincent
  last_name: Mercier
- first_name: Xiuyun
  full_name: Jiang, Xiuyun
  last_name: Jiang
- first_name: Joachim
  full_name: Moser von Filseck, Joachim
  last_name: Moser von Filseck
- first_name: Buzz
  full_name: Baum, Buzz
  last_name: Baum
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Aurélien
  full_name: Roux, Aurélien
  last_name: Roux
citation:
  ama: Pfitzner A-K, Mercier V, Jiang X, et al. An ESCRT-III polymerization sequence
    drives membrane deformation and fission. <i>Cell</i>. 2020;182(5):1140-1155.e18.
    doi:<a href="https://doi.org/10.1016/j.cell.2020.07.021">10.1016/j.cell.2020.07.021</a>
  apa: Pfitzner, A.-K., Mercier, V., Jiang, X., Moser von Filseck, J., Baum, B., Šarić,
    A., &#38; Roux, A. (2020). An ESCRT-III polymerization sequence drives membrane
    deformation and fission. <i>Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.cell.2020.07.021">https://doi.org/10.1016/j.cell.2020.07.021</a>
  chicago: Pfitzner, Anna-Katharina, Vincent Mercier, Xiuyun Jiang, Joachim Moser
    von Filseck, Buzz Baum, Anđela Šarić, and Aurélien Roux. “An ESCRT-III Polymerization
    Sequence Drives Membrane Deformation and Fission.” <i>Cell</i>. Elsevier, 2020.
    <a href="https://doi.org/10.1016/j.cell.2020.07.021">https://doi.org/10.1016/j.cell.2020.07.021</a>.
  ieee: A.-K. Pfitzner <i>et al.</i>, “An ESCRT-III polymerization sequence drives
    membrane deformation and fission,” <i>Cell</i>, vol. 182, no. 5. Elsevier, p.
    1140–1155.e18, 2020.
  ista: Pfitzner A-K, Mercier V, Jiang X, Moser von Filseck J, Baum B, Šarić A, Roux
    A. 2020. An ESCRT-III polymerization sequence drives membrane deformation and
    fission. Cell. 182(5), 1140–1155.e18.
  mla: Pfitzner, Anna-Katharina, et al. “An ESCRT-III Polymerization Sequence Drives
    Membrane Deformation and Fission.” <i>Cell</i>, vol. 182, no. 5, Elsevier, 2020,
    p. 1140–1155.e18, doi:<a href="https://doi.org/10.1016/j.cell.2020.07.021">10.1016/j.cell.2020.07.021</a>.
  short: A.-K. Pfitzner, V. Mercier, X. Jiang, J. Moser von Filseck, B. Baum, A. Šarić,
    A. Roux, Cell 182 (2020) 1140–1155.e18.
date_created: 2021-11-26T08:02:27Z
date_published: 2020-08-18T00:00:00Z
date_updated: 2021-11-26T08:58:37Z
day: '18'
doi: 10.1016/j.cell.2020.07.021
extern: '1'
external_id:
  pmid:
  - '32814015'
intvolume: '       182'
issue: '5'
keyword:
- general biochemistry
- genetics and molecular biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.sciencedirect.com/science/article/pii/S0092867420309296
month: '08'
oa: 1
oa_version: Published Version
page: 1140-1155.e18
pmid: 1
publication: Cell
publication_identifier:
  issn:
  - 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: An ESCRT-III polymerization sequence drives membrane deformation and fission
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 182
year: '2020'
...
---
_id: '10349'
abstract:
- lang: eng
  text: Sulfolobus acidocaldarius is the closest experimentally tractable archaeal
    relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and
    cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases
    of DNA replication and division. Here, in exploring the mechanism of cell division
    in S. acidocaldarius, we identify a role for the archaeal proteasome in regulating
    the transition from the end of one cell cycle to the beginning of the next. Further,
    we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome
    and show that its degradation triggers division by allowing constriction of the
    CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism
    for ESCRT-III–mediated membrane remodeling and point to a conserved role for the
    proteasome in eukaryotic and archaeal cell cycle control.
acknowledgement: "We thank the MRC LMCB at UCL for their support; the flow cytometry
  STP at the Francis Crick Institute for assistance, with special thanks to S. Purewal
  and D. Davis; C. Bertoli for mentorship\r\nand advice; J. M. Garcia-Arcos for help
  early on in this project; the entire Baum lab for their input throughout the project;
  the Albers lab for advice and reagents, with special thanks to M. Van Wolferen and
  S. Albers; the members of the Wellcome consortium for archaeal cytoskeleton studies
  for advice and comments; and J. Löwe, S. Oliferenko, M. Balasubramanian, and D.
  Gerlich for discussions and advice on the manuscript. N.P.R. and S.B. would like
  to thank N. Rzechorzek, A. Simon, and S. Anjum for discussion and advice."
article_processing_charge: No
article_type: original
author:
- first_name: Gabriel
  full_name: Tarrason Risa, Gabriel
  last_name: Tarrason Risa
- first_name: Fredrik
  full_name: Hurtig, Fredrik
  last_name: Hurtig
- first_name: Sian
  full_name: Bray, Sian
  last_name: Bray
- first_name: Anne E.
  full_name: Hafner, Anne E.
  last_name: Hafner
- first_name: Lena
  full_name: Harker-Kirschneck, Lena
  last_name: Harker-Kirschneck
- first_name: Peter
  full_name: Faull, Peter
  last_name: Faull
- first_name: Colin
  full_name: Davis, Colin
  last_name: Davis
- first_name: Dimitra
  full_name: Papatziamou, Dimitra
  last_name: Papatziamou
- first_name: Delyan R.
  full_name: Mutavchiev, Delyan R.
  last_name: Mutavchiev
- first_name: Catherine
  full_name: Fan, Catherine
  last_name: Fan
- first_name: Leticia
  full_name: Meneguello, Leticia
  last_name: Meneguello
- first_name: Andre
  full_name: Arashiro Pulschen, Andre
  last_name: Arashiro Pulschen
- first_name: Gautam
  full_name: Dey, Gautam
  last_name: Dey
- first_name: Siân
  full_name: Culley, Siân
  last_name: Culley
- first_name: Mairi
  full_name: Kilkenny, Mairi
  last_name: Kilkenny
- first_name: Diorge P.
  full_name: Souza, Diorge P.
  last_name: Souza
- first_name: Luca
  full_name: Pellegrini, Luca
  last_name: Pellegrini
- first_name: Robertus A. M.
  full_name: de Bruin, Robertus A. M.
  last_name: de Bruin
- first_name: Ricardo
  full_name: Henriques, Ricardo
  last_name: Henriques
- first_name: Ambrosius P.
  full_name: Snijders, Ambrosius P.
  last_name: Snijders
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Ann-Christin
  full_name: Lindås, Ann-Christin
  last_name: Lindås
- first_name: Nicholas P.
  full_name: Robinson, Nicholas P.
  last_name: Robinson
- first_name: Buzz
  full_name: Baum, Buzz
  last_name: Baum
citation:
  ama: Tarrason Risa G, Hurtig F, Bray S, et al. The proteasome controls ESCRT-III–mediated
    cell division in an archaeon. <i>Science</i>. 2020;369(6504). doi:<a href="https://doi.org/10.1126/science.aaz2532">10.1126/science.aaz2532</a>
  apa: Tarrason Risa, G., Hurtig, F., Bray, S., Hafner, A. E., Harker-Kirschneck,
    L., Faull, P., … Baum, B. (2020). The proteasome controls ESCRT-III–mediated cell
    division in an archaeon. <i>Science</i>. American Association for the Advancement
    of Science. <a href="https://doi.org/10.1126/science.aaz2532">https://doi.org/10.1126/science.aaz2532</a>
  chicago: Tarrason Risa, Gabriel, Fredrik Hurtig, Sian Bray, Anne E. Hafner, Lena
    Harker-Kirschneck, Peter Faull, Colin Davis, et al. “The Proteasome Controls ESCRT-III–Mediated
    Cell Division in an Archaeon.” <i>Science</i>. American Association for the Advancement
    of Science, 2020. <a href="https://doi.org/10.1126/science.aaz2532">https://doi.org/10.1126/science.aaz2532</a>.
  ieee: G. Tarrason Risa <i>et al.</i>, “The proteasome controls ESCRT-III–mediated
    cell division in an archaeon,” <i>Science</i>, vol. 369, no. 6504. American Association
    for the Advancement of Science, 2020.
  ista: Tarrason Risa G, Hurtig F, Bray S, Hafner AE, Harker-Kirschneck L, Faull P,
    Davis C, Papatziamou D, Mutavchiev DR, Fan C, Meneguello L, Arashiro Pulschen
    A, Dey G, Culley S, Kilkenny M, Souza DP, Pellegrini L, de Bruin RAM, Henriques
    R, Snijders AP, Šarić A, Lindås A-C, Robinson NP, Baum B. 2020. The proteasome
    controls ESCRT-III–mediated cell division in an archaeon. Science. 369(6504).
  mla: Tarrason Risa, Gabriel, et al. “The Proteasome Controls ESCRT-III–Mediated
    Cell Division in an Archaeon.” <i>Science</i>, vol. 369, no. 6504, American Association
    for the Advancement of Science, 2020, doi:<a href="https://doi.org/10.1126/science.aaz2532">10.1126/science.aaz2532</a>.
  short: G. Tarrason Risa, F. Hurtig, S. Bray, A.E. Hafner, L. Harker-Kirschneck,
    P. Faull, C. Davis, D. Papatziamou, D.R. Mutavchiev, C. Fan, L. Meneguello, A.
    Arashiro Pulschen, G. Dey, S. Culley, M. Kilkenny, D.P. Souza, L. Pellegrini,
    R.A.M. de Bruin, R. Henriques, A.P. Snijders, A. Šarić, A.-C. Lindås, N.P. Robinson,
    B. Baum, Science 369 (2020).
date_created: 2021-11-26T08:21:34Z
date_published: 2020-08-07T00:00:00Z
date_updated: 2021-11-26T08:58:33Z
day: '07'
doi: 10.1126/science.aaz2532
extern: '1'
external_id:
  pmid:
  - '32764038'
intvolume: '       369'
issue: '6504'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/774273v1
month: '08'
oa: 1
oa_version: Preprint
pmid: 1
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: The proteasome controls ESCRT-III–mediated cell division in an archaeon
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 369
year: '2020'
...
