---
_id: '6761'
abstract:
- lang: eng
text: In resource allocation games, selfish players share resources that are needed
in order to fulfill their objectives. The cost of using a resource depends on
the load on it. In the traditional setting, the players make their choices concurrently
and in one-shot. That is, a strategy for a player is a subset of the resources.
We introduce and study dynamic resource allocation games. In this setting, the
game proceeds in phases. In each phase each player chooses one resource. A scheduler
dictates the order in which the players proceed in a phase, possibly scheduling
several players to proceed concurrently. The game ends when each player has collected
a set of resources that fulfills his objective. The cost for each player then
depends on this set as well as on the load on the resources in it – we consider
both congestion and cost-sharing games. We argue that the dynamic setting is the
suitable setting for many applications in practice. We study the stability of
dynamic resource allocation games, where the appropriate notion of stability is
that of subgame perfect equilibrium, study the inefficiency incurred due to selfish
behavior, and also study problems that are particular to the dynamic setting,
like constraints on the order in which resources can be chosen or the problem
of finding a scheduler that achieves stability.
article_processing_charge: No
article_type: original
author:
- first_name: Guy
full_name: Avni, Guy
id: 463C8BC2-F248-11E8-B48F-1D18A9856A87
last_name: Avni
orcid: 0000-0001-5588-8287
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Orna
full_name: Kupferman, Orna
last_name: Kupferman
citation:
ama: Avni G, Henzinger TA, Kupferman O. Dynamic resource allocation games. Theoretical
Computer Science. 2020;807:42-55. doi:10.1016/j.tcs.2019.06.031
apa: Avni, G., Henzinger, T. A., & Kupferman, O. (2020). Dynamic resource allocation
games. Theoretical Computer Science. Elsevier. https://doi.org/10.1016/j.tcs.2019.06.031
chicago: Avni, Guy, Thomas A Henzinger, and Orna Kupferman. “Dynamic Resource Allocation
Games.” Theoretical Computer Science. Elsevier, 2020. https://doi.org/10.1016/j.tcs.2019.06.031.
ieee: G. Avni, T. A. Henzinger, and O. Kupferman, “Dynamic resource allocation games,”
Theoretical Computer Science, vol. 807. Elsevier, pp. 42–55, 2020.
ista: Avni G, Henzinger TA, Kupferman O. 2020. Dynamic resource allocation games.
Theoretical Computer Science. 807, 42–55.
mla: Avni, Guy, et al. “Dynamic Resource Allocation Games.” Theoretical Computer
Science, vol. 807, Elsevier, 2020, pp. 42–55, doi:10.1016/j.tcs.2019.06.031.
short: G. Avni, T.A. Henzinger, O. Kupferman, Theoretical Computer Science 807 (2020)
42–55.
date_created: 2019-08-04T21:59:20Z
date_published: 2020-02-06T00:00:00Z
date_updated: 2026-04-16T09:35:15Z
day: '06'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1016/j.tcs.2019.06.031
external_id:
isi:
- '000512219400004'
file:
- access_level: open_access
checksum: e86635417f45eb2cd75778f91382f737
content_type: application/pdf
creator: dernst
date_created: 2020-10-09T06:31:22Z
date_updated: 2020-10-09T06:31:22Z
file_id: '8639'
file_name: 2020_TheoreticalCS_Avni.pdf
file_size: 1413001
relation: main_file
success: 1
file_date_updated: 2020-10-09T06:31:22Z
has_accepted_license: '1'
intvolume: ' 807'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Submitted Version
page: 42-55
project:
- _id: 25F2ACDE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11402-N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: Formal methods for the design and analysis of complex systems
- _id: 264B3912-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02369
name: Formal Methods meets Algorithmic Game Theory
publication: Theoretical Computer Science
publication_identifier:
issn:
- 0304-3975
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '1341'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Dynamic resource allocation games
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 807
year: '2020'
...
---
_id: '7623'
abstract:
- lang: eng
text: A two-dimensional mathematical model for cells migrating without adhesion
capabilities is presented and analyzed. Cells are represented by their cortex,
which is modeled as an elastic curve, subject to an internal pressure force. Net
polymerization or depolymerization in the cortex is modeled via local addition
or removal of material, driving a cortical flow. The model takes the form of a
fully nonlinear degenerate parabolic system. An existence analysis is carried
out by adapting ideas from the theory of gradient flows. Numerical simulations
show that these simple rules can account for the behavior observed in experiments,
suggesting a possible mechanical mechanism for adhesion-independent motility.
acknowledgement: This work has been supported by the Vienna Science and Technology
Fund, Grant no. LS13-029. G.J. and C.S. also acknowledge support by the Austrian
Science Fund, Grants no. W1245, F 65, and W1261, as well as by the Fondation Sciences
Mathématiques de Paris, and by Paris-Sciences-et-Lettres.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Gaspard
full_name: Jankowiak, Gaspard
last_name: Jankowiak
- first_name: Diane
full_name: Peurichard, Diane
last_name: Peurichard
- first_name: Anne
full_name: Reversat, Anne
id: 35B76592-F248-11E8-B48F-1D18A9856A87
last_name: Reversat
orcid: 0000-0003-0666-8928
- first_name: Christian
full_name: Schmeiser, Christian
last_name: Schmeiser
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Jankowiak G, Peurichard D, Reversat A, Schmeiser C, Sixt MK. Modeling adhesion-independent
cell migration. Mathematical Models and Methods in Applied Sciences. 2020;30(3):513-537.
doi:10.1142/S021820252050013X
apa: Jankowiak, G., Peurichard, D., Reversat, A., Schmeiser, C., & Sixt, M.
K. (2020). Modeling adhesion-independent cell migration. Mathematical Models
and Methods in Applied Sciences. World Scientific Publishing. https://doi.org/10.1142/S021820252050013X
chicago: Jankowiak, Gaspard, Diane Peurichard, Anne Reversat, Christian Schmeiser,
and Michael K Sixt. “Modeling Adhesion-Independent Cell Migration.” Mathematical
Models and Methods in Applied Sciences. World Scientific Publishing, 2020.
https://doi.org/10.1142/S021820252050013X.
ieee: G. Jankowiak, D. Peurichard, A. Reversat, C. Schmeiser, and M. K. Sixt, “Modeling
adhesion-independent cell migration,” Mathematical Models and Methods in Applied
Sciences, vol. 30, no. 3. World Scientific Publishing, pp. 513–537, 2020.
ista: Jankowiak G, Peurichard D, Reversat A, Schmeiser C, Sixt MK. 2020. Modeling
adhesion-independent cell migration. Mathematical Models and Methods in Applied
Sciences. 30(3), 513–537.
mla: Jankowiak, Gaspard, et al. “Modeling Adhesion-Independent Cell Migration.”
Mathematical Models and Methods in Applied Sciences, vol. 30, no. 3, World
Scientific Publishing, 2020, pp. 513–37, doi:10.1142/S021820252050013X.
short: G. Jankowiak, D. Peurichard, A. Reversat, C. Schmeiser, M.K. Sixt, Mathematical
Models and Methods in Applied Sciences 30 (2020) 513–537.
date_created: 2020-03-31T11:25:05Z
date_published: 2020-03-18T00:00:00Z
date_updated: 2026-04-16T09:35:31Z
day: '18'
department:
- _id: MiSi
doi: 10.1142/S021820252050013X
external_id:
arxiv:
- '1903.09426'
isi:
- '000525349900003'
intvolume: ' 30'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1903.09426
month: '03'
oa: 1
oa_version: Preprint
page: 513-537
project:
- _id: 25AD6156-B435-11E9-9278-68D0E5697425
grant_number: LS13-029
name: Modeling of Polarization and Motility of Leukocytes in Three-Dimensional Environments
publication: Mathematical Models and Methods in Applied Sciences
publication_identifier:
issn:
- 0218-2025
publication_status: published
publisher: World Scientific Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modeling adhesion-independent cell migration
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 30
year: '2020'
...
---
OA_place: publisher
_id: '8386'
abstract:
- lang: eng
text: "Form versus function is a long-standing debate in various design-related
fields, such as architecture as well as graphic and industrial design. A good
design that balances form and function often requires considerable human effort
and collaboration among experts from different professional fields. Computational
design tools provide a new paradigm for designing functional objects. In computational
design, form and function are represented as mathematical\r\nquantities, with
the help of numerical and combinatorial algorithms, they can assist even novice
users in designing versatile models that exhibit their desired functionality.
This thesis presents three disparate research studies on the computational design
of functional objects: The appearance of 3d print—we optimize the volumetric material
distribution for faithfully replicating colored surface texture in 3d printing;
the dynamic motion of mechanical structures—\r\nour design system helps the novice
user to retarget various mechanical templates with different functionality to
complex 3d shapes; and a more abstract functionality, multistability—our algorithm
automatically generates models that exhibit multiple stable target poses. For
each of these cases, our computational design tools not only ensure the functionality
of the results but also permit the user aesthetic freedom over the form. Moreover,
fabrication constraints\r\nwere taken into account, which allow for the immediate
creation of physical realization via 3D printing or laser cutting."
acknowledged_ssus:
- _id: SSU
acknowledgement: The research in this thesis has received funding from the European
Union’s Horizon 2020 research and innovation programme, under the Marie Skłodowska-Curie
grant agreement No 642841 (DISTRO) and the European Research Council grant agreement
No 715767 (MATERIALIZABLE). All the research projects in this thesis were also supported
by Scientific Service Units (SSUs) at IST Austria.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Ran
full_name: Zhang, Ran
id: 4DDBCEB0-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0002-3808-281X
citation:
ama: Zhang R. Structure-aware computational design and its application to 3D printable
volume scattering, mechanism, and multistability. 2020. doi:10.15479/AT:ISTA:8386
apa: Zhang, R. (2020). Structure-aware computational design and its application
to 3D printable volume scattering, mechanism, and multistability. Institute
of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8386
chicago: Zhang, Ran. “Structure-Aware Computational Design and Its Application to
3D Printable Volume Scattering, Mechanism, and Multistability.” Institute of Science
and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8386.
ieee: R. Zhang, “Structure-aware computational design and its application to 3D
printable volume scattering, mechanism, and multistability,” Institute of Science
and Technology Austria, 2020.
ista: Zhang R. 2020. Structure-aware computational design and its application to
3D printable volume scattering, mechanism, and multistability. Institute of Science
and Technology Austria.
mla: Zhang, Ran. Structure-Aware Computational Design and Its Application to
3D Printable Volume Scattering, Mechanism, and Multistability. Institute of
Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8386.
short: R. Zhang, Structure-Aware Computational Design and Its Application to 3D
Printable Volume Scattering, Mechanism, and Multistability, Institute of Science
and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-09-14T01:04:53Z
date_published: 2020-09-14T00:00:00Z
date_updated: 2026-04-16T10:06:31Z
day: '14'
ddc:
- '003'
degree_awarded: PhD
department:
- _id: BeBi
doi: 10.15479/AT:ISTA:8386
ec_funded: 1
file:
- access_level: closed
checksum: edcf578b6e1c9b0dd81ff72d319b66ba
content_type: application/x-zip-compressed
creator: rzhang
date_created: 2020-09-14T01:02:59Z
date_updated: 2020-09-14T12:18:43Z
file_id: '8388'
file_name: Thesis_Ran.zip
file_size: 1245800191
relation: source_file
- access_level: open_access
checksum: 817e20c33be9247f906925517c56a40d
content_type: application/pdf
creator: rzhang
date_created: 2020-09-15T12:51:53Z
date_updated: 2020-09-15T12:51:53Z
file_id: '8396'
file_name: PhD_thesis_Ran Zhang_20200915.pdf
file_size: 161385316
relation: main_file
success: 1
file_date_updated: 2020-09-15T12:51:53Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '148'
project:
- _id: 2508E324-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '642841'
name: Distributed 3D Object Design
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '486'
relation: part_of_dissertation
status: public
- id: '1002'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
title: Structure-aware computational design and its application to 3D printable volume
scattering, mechanism, and multistability
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
_id: '7966'
abstract:
- lang: eng
text: "For 1≤m≤n, we consider a natural m-out-of-n multi-instance scenario for a
public-key encryption (PKE) scheme. An adversary, given n independent instances
of PKE, wins if he breaks at least m out of the n instances. In this work, we
are interested in the scaling factor of PKE schemes, SF, which measures how well
the difficulty of breaking m out of the n instances scales in m. That is, a scaling
factor SF=ℓ indicates that breaking m out of n instances is at least ℓ times more
difficult than breaking one single instance. A PKE scheme with small scaling factor
hence provides an ideal target for mass surveillance. In fact, the Logjam attack
(CCS 2015) implicitly exploited, among other things, an almost constant scaling
factor of ElGamal over finite fields (with shared group parameters).\r\n\r\nFor
Hashed ElGamal over elliptic curves, we use the generic group model to argue that
the scaling factor depends on the scheme's granularity. In low granularity, meaning
each public key contains its independent group parameter, the scheme has optimal
scaling factor SF=m; In medium and high granularity, meaning all public keys share
the same group parameter, the scheme still has a reasonable scaling factor SF=√m.
Our findings underline that instantiating ElGamal over elliptic curves should
be preferred to finite fields in a multi-instance scenario.\r\n\r\nAs our main
technical contribution, we derive new generic-group lower bounds of Ω(√(mp)) on
the difficulty of solving both the m-out-of-n Gap Discrete Logarithm and the m-out-of-n
Gap Computational Diffie-Hellman problem over groups of prime order p, extending
a recent result by Yun (EUROCRYPT 2015). We establish the lower bound by studying
the hardness of a related computational problem which we call the search-by-hypersurface
problem."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Benedikt
full_name: Auerbach, Benedikt
id: D33D2B18-E445-11E9-ABB7-15F4E5697425
last_name: Auerbach
orcid: 0000-0002-7553-6606
- first_name: Federico
full_name: Giacon, Federico
last_name: Giacon
- first_name: Eike
full_name: Kiltz, Eike
last_name: Kiltz
citation:
ama: 'Auerbach B, Giacon F, Kiltz E. Everybody’s a target: Scalability in public-key
encryption. In: Advances in Cryptology – EUROCRYPT 2020. Vol 12107. Springer
Nature; 2020:475-506. doi:10.1007/978-3-030-45727-3_16'
apa: 'Auerbach, B., Giacon, F., & Kiltz, E. (2020). Everybody’s a target: Scalability
in public-key encryption. In Advances in Cryptology – EUROCRYPT 2020 (Vol.
12107, pp. 475–506). Springer Nature. https://doi.org/10.1007/978-3-030-45727-3_16'
chicago: 'Auerbach, Benedikt, Federico Giacon, and Eike Kiltz. “Everybody’s a Target:
Scalability in Public-Key Encryption.” In Advances in Cryptology – EUROCRYPT
2020, 12107:475–506. Springer Nature, 2020. https://doi.org/10.1007/978-3-030-45727-3_16.'
ieee: 'B. Auerbach, F. Giacon, and E. Kiltz, “Everybody’s a target: Scalability
in public-key encryption,” in Advances in Cryptology – EUROCRYPT 2020,
2020, vol. 12107, pp. 475–506.'
ista: 'Auerbach B, Giacon F, Kiltz E. 2020. Everybody’s a target: Scalability in
public-key encryption. Advances in Cryptology – EUROCRYPT 2020. EUROCRYPT: Theory
and Applications of Cryptographic Techniques, LNCS, vol. 12107, 475–506.'
mla: 'Auerbach, Benedikt, et al. “Everybody’s a Target: Scalability in Public-Key
Encryption.” Advances in Cryptology – EUROCRYPT 2020, vol. 12107, Springer
Nature, 2020, pp. 475–506, doi:10.1007/978-3-030-45727-3_16.'
short: B. Auerbach, F. Giacon, E. Kiltz, in:, Advances in Cryptology – EUROCRYPT
2020, Springer Nature, 2020, pp. 475–506.
conference:
end_date: 2020-05-15
name: 'EUROCRYPT: Theory and Applications of Cryptographic Techniques'
start_date: 2020-05-11
date_created: 2020-06-15T07:13:37Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2026-04-16T10:21:02Z
day: '01'
department:
- _id: KrPi
doi: 10.1007/978-3-030-45727-3_16
ec_funded: 1
external_id:
isi:
- '000828688000016'
intvolume: ' 12107'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2019/364
month: '05'
oa: 1
oa_version: Submitted Version
page: 475-506
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
publication: Advances in Cryptology – EUROCRYPT 2020
publication_identifier:
eisbn:
- '9783030457273'
eissn:
- 1611-3349
isbn:
- '9783030457266'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Everybody’s a target: Scalability in public-key encryption'
type: conference
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 12107
year: '2020'
...
---
_id: '8623'
abstract:
- lang: eng
text: We introduce the monitoring of trace properties under assumptions. An assumption
limits the space of possible traces that the monitor may encounter. An assumption
may result from knowledge about the system that is being monitored, about the
environment, or about another, connected monitor. We define monitorability under
assumptions and study its theoretical properties. In particular, we show that
for every assumption A, the boolean combinations of properties that are safe or
co-safe relative to A are monitorable under A. We give several examples and constructions
on how an assumption can make a non-monitorable property monitorable, and how
an assumption can make a monitorable property monitorable with fewer resources,
such as integer registers.
acknowledgement: This research was supported in part by the Austrian Science Fund
(FWF) under grant Z211-N23 (Wittgenstein Award).
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Naci E
full_name: Sarac, Naci E
id: 8C6B42F8-C8E6-11E9-A03A-F2DCE5697425
last_name: Sarac
citation:
ama: 'Henzinger TA, Sarac NE. Monitorability under assumptions. In: Runtime Verification.
Vol 12399. Springer Nature; 2020:3-18. doi:10.1007/978-3-030-60508-7_1'
apa: 'Henzinger, T. A., & Sarac, N. E. (2020). Monitorability under assumptions.
In Runtime Verification (Vol. 12399, pp. 3–18). Los Angeles, CA, United
States: Springer Nature. https://doi.org/10.1007/978-3-030-60508-7_1'
chicago: Henzinger, Thomas A, and Naci E Sarac. “Monitorability under Assumptions.”
In Runtime Verification, 12399:3–18. Springer Nature, 2020. https://doi.org/10.1007/978-3-030-60508-7_1.
ieee: T. A. Henzinger and N. E. Sarac, “Monitorability under assumptions,” in Runtime
Verification, Los Angeles, CA, United States, 2020, vol. 12399, pp. 3–18.
ista: 'Henzinger TA, Sarac NE. 2020. Monitorability under assumptions. Runtime Verification.
RV: Runtime Verification, LNCS, vol. 12399, 3–18.'
mla: Henzinger, Thomas A., and Naci E. Sarac. “Monitorability under Assumptions.”
Runtime Verification, vol. 12399, Springer Nature, 2020, pp. 3–18, doi:10.1007/978-3-030-60508-7_1.
short: T.A. Henzinger, N.E. Sarac, in:, Runtime Verification, Springer Nature, 2020,
pp. 3–18.
conference:
end_date: 2020-10-09
location: Los Angeles, CA, United States
name: 'RV: Runtime Verification'
start_date: 2020-10-06
date_created: 2020-10-07T15:05:37Z
date_published: 2020-10-02T00:00:00Z
date_updated: 2026-04-16T10:22:01Z
day: '02'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-030-60508-7_1
external_id:
isi:
- '000728160600001'
file:
- access_level: open_access
checksum: 00661f9b7034f52e18bf24fa552b8194
content_type: application/pdf
creator: esarac
date_created: 2020-10-15T14:28:06Z
date_updated: 2020-10-15T14:28:06Z
file_id: '8665'
file_name: monitorability.pdf
file_size: 478148
relation: main_file
success: 1
file_date_updated: 2020-10-15T14:28:06Z
has_accepted_license: '1'
intvolume: ' 12399'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
page: 3-18
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: Formal methods for the design and analysis of complex systems
publication: Runtime Verification
publication_identifier:
eisbn:
- '9783030605087'
eissn:
- 1611-3349
isbn:
- '9783030605070'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Monitorability under assumptions
type: conference
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 12399
year: '2020'
...
---
_id: '10865'
abstract:
- lang: eng
text: "We introduce the notion of Witness Maps as a cryptographic notion of a proof
system. A Unique Witness Map (UWM) deterministically maps all witnesses for an
\ NP statement to a single representative witness, resulting in a computationally
sound, deterministic-prover, non-interactive witness independent proof system.
A relaxation of UWM, called Compact Witness Map (CWM), maps all the witnesses
to a small number of witnesses, resulting in a “lossy” deterministic-prover, non-interactive
proof-system. We also define a Dual Mode Witness Map (DMWM) which adds an “extractable”
mode to a CWM.\r\nOur main construction is a DMWM for all NP relations, assuming
sub-exponentially secure indistinguishability obfuscation ( iO ), along with
standard cryptographic assumptions. The DMWM construction relies on a CWM and
a new primitive called Cumulative All-Lossy-But-One Trapdoor Functions (C-ALBO-TDF),
both of which are in turn instantiated based on iO and other primitives. Our
instantiation of a CWM is in fact a UWM; in turn, we show that a UWM implies Witness
Encryption. Along the way to constructing UWM and C-ALBO-TDF, we also construct,
from standard assumptions, Puncturable Digital Signatures and a new primitive
called Cumulative Lossy Trapdoor Functions (C-LTDF). The former improves up on
a construction of Bellare et al. (Eurocrypt 2016), who relied on sub-exponentially
secure iO and sub-exponentially secure OWF.\r\nAs an application of our constructions,
we show how to use a DMWM to construct the first leakage and tamper-resilient
signatures with a deterministic signer, thereby solving a decade old open problem
posed by Katz and Vaikunthanathan (Asiacrypt 2009), by Boyle, Segev and Wichs
(Eurocrypt 2011), as well as by Faonio and Venturi (Asiacrypt 2016). Our construction
achieves the optimal leakage rate of 1−o(1) ."
acknowledgement: We would like to thank the anonymous reviewers of PKC 2019 for their
useful comments and suggestions. We thank Omer Paneth for pointing out to us the
connection between Unique Witness Maps (UWM) and Witness encryption (WE). The first
author would like to acknowledge Pandu Rangan for his involvement during the initial
discussion phase of the project.
article_processing_charge: No
author:
- first_name: Suvradip
full_name: Chakraborty, Suvradip
id: B9CD0494-D033-11E9-B219-A439E6697425
last_name: Chakraborty
- first_name: Manoj
full_name: Prabhakaran, Manoj
last_name: Prabhakaran
- first_name: Daniel
full_name: Wichs, Daniel
last_name: Wichs
citation:
ama: 'Chakraborty S, Prabhakaran M, Wichs D. Witness maps and applications. In:
Kiayias A, ed. Public-Key Cryptography. Vol 12110. LNCS. Cham: Springer
Nature; 2020:220-246. doi:10.1007/978-3-030-45374-9_8'
apa: 'Chakraborty, S., Prabhakaran, M., & Wichs, D. (2020). Witness maps and
applications. In A. Kiayias (Ed.), Public-Key Cryptography (Vol. 12110,
pp. 220–246). Cham: Springer Nature. https://doi.org/10.1007/978-3-030-45374-9_8'
chicago: 'Chakraborty, Suvradip, Manoj Prabhakaran, and Daniel Wichs. “Witness Maps
and Applications.” In Public-Key Cryptography, edited by A Kiayias, 12110:220–46.
LNCS. Cham: Springer Nature, 2020. https://doi.org/10.1007/978-3-030-45374-9_8.'
ieee: 'S. Chakraborty, M. Prabhakaran, and D. Wichs, “Witness maps and applications,”
in Public-Key Cryptography, vol. 12110, A. Kiayias, Ed. Cham: Springer
Nature, 2020, pp. 220–246.'
ista: 'Chakraborty S, Prabhakaran M, Wichs D. 2020.Witness maps and applications.
In: Public-Key Cryptography. vol. 12110, 220–246.'
mla: Chakraborty, Suvradip, et al. “Witness Maps and Applications.” Public-Key
Cryptography, edited by A Kiayias, vol. 12110, Springer Nature, 2020, pp.
220–46, doi:10.1007/978-3-030-45374-9_8.
short: S. Chakraborty, M. Prabhakaran, D. Wichs, in:, A. Kiayias (Ed.), Public-Key
Cryptography, Springer Nature, Cham, 2020, pp. 220–246.
corr_author: '1'
date_created: 2022-03-18T11:35:51Z
date_published: 2020-04-29T00:00:00Z
date_updated: 2026-04-16T10:21:31Z
day: '29'
doi: 10.1007/978-3-030-45374-9_8
editor:
- first_name: A
full_name: Kiayias, A
last_name: Kiayias
external_id:
isi:
- '001299210200008'
intvolume: ' 12110'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2020/090
month: '04'
oa: 1
oa_version: Preprint
page: 220-246
place: Cham
publication: Public-Key Cryptography
publication_identifier:
eisbn:
- '9783030453749'
eissn:
- 1611-3349
isbn:
- '9783030453732'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: LNCS
status: public
title: Witness maps and applications
type: book_chapter
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 12110
year: '2020'
...
---
_id: '6649'
abstract:
- lang: eng
text: "While Hartree–Fock theory is well established as a fundamental approximation
for interacting fermions, it has been unclear how to describe corrections to it
due to many-body correlations. In this paper we start from the Hartree–Fock state
given by plane waves and introduce collective particle–hole pair excitations.
These pairs can be approximately described by a bosonic quadratic Hamiltonian.
We use Bogoliubov theory to construct a trial state yielding a rigorous Gell-Mann–Brueckner–type
upper bound to the ground state energy. Our result justifies the random-phase
approximation in the mean-field scaling regime, for repulsive, regular interaction
potentials.\r\n"
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Niels P
full_name: Benedikter, Niels P
id: 3DE6C32A-F248-11E8-B48F-1D18A9856A87
last_name: Benedikter
orcid: 0000-0002-1071-6091
- first_name: Phan Thành
full_name: Nam, Phan Thành
last_name: Nam
- first_name: Marcello
full_name: Porta, Marcello
last_name: Porta
- first_name: Benjamin
full_name: Schlein, Benjamin
last_name: Schlein
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Benedikter NP, Nam PT, Porta M, Schlein B, Seiringer R. Optimal upper bound
for the correlation energy of a Fermi gas in the mean-field regime. Communications
in Mathematical Physics. 2020;374:2097–2150. doi:10.1007/s00220-019-03505-5
apa: Benedikter, N. P., Nam, P. T., Porta, M., Schlein, B., & Seiringer, R.
(2020). Optimal upper bound for the correlation energy of a Fermi gas in the mean-field
regime. Communications in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s00220-019-03505-5
chicago: Benedikter, Niels P, Phan Thành Nam, Marcello Porta, Benjamin Schlein,
and Robert Seiringer. “Optimal Upper Bound for the Correlation Energy of a Fermi
Gas in the Mean-Field Regime.” Communications in Mathematical Physics.
Springer Nature, 2020. https://doi.org/10.1007/s00220-019-03505-5.
ieee: N. P. Benedikter, P. T. Nam, M. Porta, B. Schlein, and R. Seiringer, “Optimal
upper bound for the correlation energy of a Fermi gas in the mean-field regime,”
Communications in Mathematical Physics, vol. 374. Springer Nature, pp.
2097–2150, 2020.
ista: Benedikter NP, Nam PT, Porta M, Schlein B, Seiringer R. 2020. Optimal upper
bound for the correlation energy of a Fermi gas in the mean-field regime. Communications
in Mathematical Physics. 374, 2097–2150.
mla: Benedikter, Niels P., et al. “Optimal Upper Bound for the Correlation Energy
of a Fermi Gas in the Mean-Field Regime.” Communications in Mathematical Physics,
vol. 374, Springer Nature, 2020, pp. 2097–2150, doi:10.1007/s00220-019-03505-5.
short: N.P. Benedikter, P.T. Nam, M. Porta, B. Schlein, R. Seiringer, Communications
in Mathematical Physics 374 (2020) 2097–2150.
corr_author: '1'
date_created: 2019-07-18T13:30:04Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2025-04-14T07:27:00Z
day: '01'
ddc:
- '530'
department:
- _id: RoSe
doi: 10.1007/s00220-019-03505-5
ec_funded: 1
external_id:
arxiv:
- '1809.01902'
isi:
- '000527910700019'
file:
- access_level: open_access
checksum: f9dd6dd615a698f1d3636c4a092fed23
content_type: application/pdf
creator: dernst
date_created: 2019-07-24T07:19:10Z
date_updated: 2020-07-14T12:47:35Z
file_id: '6668'
file_name: 2019_CommMathPhysics_Benedikter.pdf
file_size: 853289
relation: main_file
file_date_updated: 2020-07-14T12:47:35Z
has_accepted_license: '1'
intvolume: ' 374'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 2097–2150
project:
- _id: 3AC91DDA-15DF-11EA-824D-93A3E7B544D1
call_identifier: FWF
name: FWF Open Access Fund
- _id: 25C878CE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P27533_N27
name: Structure of the Excitation Spectrum for Many-Body Quantum Systems
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
publication: Communications in Mathematical Physics
publication_identifier:
eissn:
- 1432-0916
issn:
- 0010-3616
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Optimal upper bound for the correlation energy of a Fermi gas in the mean-field
regime
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 374
year: '2020'
...
---
_id: '7866'
abstract:
- lang: eng
text: In this paper, we establish convergence to equilibrium for a drift–diffusion–recombination
system modelling the charge transport within certain semiconductor devices. More
precisely, we consider a two-level system for electrons and holes which is augmented
by an intermediate energy level for electrons in so-called trapped states. The
recombination dynamics use the mass action principle by taking into account this
additional trap level. The main part of the paper is concerned with the derivation
of an entropy–entropy production inequality, which entails exponential convergence
to the equilibrium via the so-called entropy method. The novelty of our approach
lies in the fact that the entropy method is applied uniformly in a fast-reaction
parameter which governs the lifetime of electrons on the trap level. Thus, the
resulting decay estimate for the densities of electrons and holes extends to the
corresponding quasi-steady-state approximation.
acknowledgement: Open access funding provided by Austrian Science Fund (FWF). The
second author has been supported by the International Research Training Group IGDK
1754 “Optimization and Numerical Analysis for Partial Differential Equations with
Nonsmooth Structures”, funded by the German Research Council (DFG) and the Austrian
Science Fund (FWF) under grant number [W 1244-N18].
article_processing_charge: No
article_type: original
author:
- first_name: Klemens
full_name: Fellner, Klemens
last_name: Fellner
- first_name: Michael
full_name: Kniely, Michael
id: 2CA2C08C-F248-11E8-B48F-1D18A9856A87
last_name: Kniely
orcid: 0000-0001-5645-4333
citation:
ama: Fellner K, Kniely M. Uniform convergence to equilibrium for a family of drift–diffusion
models with trap-assisted recombination and the limiting Shockley–Read–Hall model.
Journal of Elliptic and Parabolic Equations. 2020;6:529-598. doi:10.1007/s41808-020-00068-8
apa: Fellner, K., & Kniely, M. (2020). Uniform convergence to equilibrium for
a family of drift–diffusion models with trap-assisted recombination and the limiting
Shockley–Read–Hall model. Journal of Elliptic and Parabolic Equations.
Springer Nature. https://doi.org/10.1007/s41808-020-00068-8
chicago: Fellner, Klemens, and Michael Kniely. “Uniform Convergence to Equilibrium
for a Family of Drift–Diffusion Models with Trap-Assisted Recombination and the
Limiting Shockley–Read–Hall Model.” Journal of Elliptic and Parabolic Equations.
Springer Nature, 2020. https://doi.org/10.1007/s41808-020-00068-8.
ieee: K. Fellner and M. Kniely, “Uniform convergence to equilibrium for a family
of drift–diffusion models with trap-assisted recombination and the limiting Shockley–Read–Hall
model,” Journal of Elliptic and Parabolic Equations, vol. 6. Springer Nature,
pp. 529–598, 2020.
ista: Fellner K, Kniely M. 2020. Uniform convergence to equilibrium for a family
of drift–diffusion models with trap-assisted recombination and the limiting Shockley–Read–Hall
model. Journal of Elliptic and Parabolic Equations. 6, 529–598.
mla: Fellner, Klemens, and Michael Kniely. “Uniform Convergence to Equilibrium for
a Family of Drift–Diffusion Models with Trap-Assisted Recombination and the Limiting
Shockley–Read–Hall Model.” Journal of Elliptic and Parabolic Equations,
vol. 6, Springer Nature, 2020, pp. 529–98, doi:10.1007/s41808-020-00068-8.
short: K. Fellner, M. Kniely, Journal of Elliptic and Parabolic Equations 6 (2020)
529–598.
corr_author: '1'
date_created: 2020-05-17T22:00:45Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2025-07-17T08:12:24Z
day: '01'
ddc:
- '510'
department:
- _id: JuFi
doi: 10.1007/s41808-020-00068-8
external_id:
pmid:
- '33195442'
file:
- access_level: open_access
checksum: 6bc6832caacddceee1471291e93dcf1d
content_type: application/pdf
creator: dernst
date_created: 2020-11-25T08:59:59Z
date_updated: 2020-11-25T08:59:59Z
file_id: '8802'
file_name: 2020_JourEllipticParabEquat_Fellner.pdf
file_size: 8408694
relation: main_file
success: 1
file_date_updated: 2020-11-25T08:59:59Z
has_accepted_license: '1'
intvolume: ' 6'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 529-598
pmid: 1
project:
- _id: 3AC91DDA-15DF-11EA-824D-93A3E7B544D1
call_identifier: FWF
name: FWF Open Access Fund
publication: Journal of Elliptic and Parabolic Equations
publication_identifier:
eissn:
- 2296-9039
issn:
- 2296-9020
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Uniform convergence to equilibrium for a family of drift–diffusion models with
trap-assisted recombination and the limiting Shockley–Read–Hall model
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2020'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21640'
abstract:
- lang: eng
text: "Conventional computing architectures have no known efficient algorithms for
combinatorial optimization tasks such\r\nas the Ising problem, which requires
finding the ground state spin configuration of an arbitrary Ising graph. Physical\r\nIsing
machines have recently been developed as an alternative to conventional exact
and heuristic solvers; however,\r\nthese machines typically suffer from decreased
ground state convergence probability or universality for high edge-\r\ndensity
graphs or arbitrary graph weights, respectively. We experimentally demonstrate
a proof-of-principle integrated\r\nnanophotonic recurrent Ising sampler (INPRIS),
using a hybrid scheme combining electronics and silicon-on-insulator\r\nphotonics,
that is capable of converging to the ground state of various four-spin graphs
with high probability. The\r\nINPRIS results indicate that noise may be used as
a resource to speed up the ground state search and to explore larger\r\nregions
of the phase space, thus allowing one to probe noise-dependent physical observables.
Since the recurrent pho-\r\ntonic transformation that our machine imparts is a
fixed function of the graph problem and therefore compatible with\r\noptoelectronic
architectures that support GHz clock rates (such as passive or non-volatile photonic
circuits that do not\r\nrequire reprogramming at each iteration), this work suggests
the potential for future systems that could achieve orders-\r\nof-magnitude speedups
in exploring the solution space of combinatorially hard problems. "
article_processing_charge: No
article_type: original
author:
- first_name: Mihika
full_name: Prabhu, Mihika
last_name: Prabhu
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: Yichen
full_name: Shen, Yichen
last_name: Shen
- first_name: Nicholas
full_name: Harris, Nicholas
last_name: Harris
- first_name: Li
full_name: Jing, Li
last_name: Jing
- first_name: Jacques
full_name: Carolan, Jacques
last_name: Carolan
- first_name: Ryan
full_name: Hamerly, Ryan
last_name: Hamerly
- first_name: Tom
full_name: Baehr-Jones, Tom
last_name: Baehr-Jones
- first_name: Michael
full_name: Hochberg, Michael
last_name: Hochberg
- first_name: Vladimir
full_name: Čeperić, Vladimir
last_name: Čeperić
- first_name: John D.
full_name: Joannopoulos, John D.
last_name: Joannopoulos
- first_name: Dirk R.
full_name: Englund, Dirk R.
last_name: Englund
- first_name: Marin
full_name: Soljačić, Marin
last_name: Soljačić
citation:
ama: Prabhu M, Roques-Carmes C, Shen Y, et al. Accelerating recurrent Ising machines
in photonic integrated circuits. Optica. 2020;7(5):551-558. doi:10.1364/optica.386613
apa: Prabhu, M., Roques-Carmes, C., Shen, Y., Harris, N., Jing, L., Carolan, J.,
… Soljačić, M. (2020). Accelerating recurrent Ising machines in photonic integrated
circuits. Optica. Optica Publishing Group. https://doi.org/10.1364/optica.386613
chicago: Prabhu, Mihika, Charles Roques-Carmes, Yichen Shen, Nicholas Harris, Li
Jing, Jacques Carolan, Ryan Hamerly, et al. “Accelerating Recurrent Ising Machines
in Photonic Integrated Circuits.” Optica. Optica Publishing Group, 2020.
https://doi.org/10.1364/optica.386613.
ieee: M. Prabhu et al., “Accelerating recurrent Ising machines in photonic
integrated circuits,” Optica, vol. 7, no. 5. Optica Publishing Group, pp.
551–558, 2020.
ista: Prabhu M, Roques-Carmes C, Shen Y, Harris N, Jing L, Carolan J, Hamerly R,
Baehr-Jones T, Hochberg M, Čeperić V, Joannopoulos JD, Englund DR, Soljačić M.
2020. Accelerating recurrent Ising machines in photonic integrated circuits. Optica.
7(5), 551–558.
mla: Prabhu, Mihika, et al. “Accelerating Recurrent Ising Machines in Photonic Integrated
Circuits.” Optica, vol. 7, no. 5, Optica Publishing Group, 2020, pp. 551–58,
doi:10.1364/optica.386613.
short: M. Prabhu, C. Roques-Carmes, Y. Shen, N. Harris, L. Jing, J. Carolan, R.
Hamerly, T. Baehr-Jones, M. Hochberg, V. Čeperić, J.D. Joannopoulos, D.R. Englund,
M. Soljačić, Optica 7 (2020) 551–558.
date_created: 2026-03-30T12:22:48Z
date_published: 2020-05-18T00:00:00Z
date_updated: 2026-04-27T07:06:04Z
day: '18'
ddc:
- '530'
doi: 10.1364/optica.386613
extern: '1'
intvolume: ' 7'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1364/OPTICA.386613
month: '05'
oa: 1
oa_version: Published Version
page: 551-558
publication: Optica
publication_identifier:
eissn:
- 2334-2536
publication_status: published
publisher: Optica Publishing Group
quality_controlled: '1'
scopus_import: '1'
status: public
title: Accelerating recurrent Ising machines in photonic integrated circuits
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2020'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21637'
abstract:
- lang: eng
text: We demonstrate new axisymmetric inverse-design techniques that can solve problems
radically different from traditional lenses, including reconfigurable lenses (that
shift a multi-frequency focal spot in response to refractive-index changes) and
widely separated multi-wavelength lenses (λ = 1 µm and 10 µm). We also present
experimental validation for an axisymmetric inverse-designed monochrome lens in
the near-infrared fabricated via two-photon polymerization. Axisymmetry allows
fullwave Maxwell solvers to be scaled up to structures hundreds or even thousands
of wavelengths in diameter before requiring domain-decomposition approximations,
while multilayer topology optimization with ∼105 degrees of freedom can tackle
challenging design problems even when restricted to axisymmetric structures.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Rasmus E.
full_name: Christiansen, Rasmus E.
last_name: Christiansen
- first_name: Zin
full_name: Lin, Zin
last_name: Lin
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: Yannick
full_name: Salamin, Yannick
last_name: Salamin
- first_name: Steven E.
full_name: Kooi, Steven E.
last_name: Kooi
- first_name: John D.
full_name: Joannopoulos, John D.
last_name: Joannopoulos
- first_name: Marin
full_name: Soljačić, Marin
last_name: Soljačić
- first_name: Steven G.
full_name: Johnson, Steven G.
last_name: Johnson
citation:
ama: Christiansen RE, Lin Z, Roques-Carmes C, et al. Fullwave Maxwell inverse design
of axisymmetric, tunable, and multi-scale multi-wavelength metalenses. Optics
Express. 2020;28(23):33854-33868. doi:10.1364/oe.403192
apa: Christiansen, R. E., Lin, Z., Roques-Carmes, C., Salamin, Y., Kooi, S. E.,
Joannopoulos, J. D., … Johnson, S. G. (2020). Fullwave Maxwell inverse design
of axisymmetric, tunable, and multi-scale multi-wavelength metalenses. Optics
Express. Optica Publishing Group. https://doi.org/10.1364/oe.403192
chicago: Christiansen, Rasmus E., Zin Lin, Charles Roques-Carmes, Yannick Salamin,
Steven E. Kooi, John D. Joannopoulos, Marin Soljačić, and Steven G. Johnson. “Fullwave
Maxwell Inverse Design of Axisymmetric, Tunable, and Multi-Scale Multi-Wavelength
Metalenses.” Optics Express. Optica Publishing Group, 2020. https://doi.org/10.1364/oe.403192.
ieee: R. E. Christiansen et al., “Fullwave Maxwell inverse design of axisymmetric,
tunable, and multi-scale multi-wavelength metalenses,” Optics Express,
vol. 28, no. 23. Optica Publishing Group, pp. 33854–33868, 2020.
ista: Christiansen RE, Lin Z, Roques-Carmes C, Salamin Y, Kooi SE, Joannopoulos
JD, Soljačić M, Johnson SG. 2020. Fullwave Maxwell inverse design of axisymmetric,
tunable, and multi-scale multi-wavelength metalenses. Optics Express. 28(23),
33854–33868.
mla: Christiansen, Rasmus E., et al. “Fullwave Maxwell Inverse Design of Axisymmetric,
Tunable, and Multi-Scale Multi-Wavelength Metalenses.” Optics Express,
vol. 28, no. 23, Optica Publishing Group, 2020, pp. 33854–68, doi:10.1364/oe.403192.
short: R.E. Christiansen, Z. Lin, C. Roques-Carmes, Y. Salamin, S.E. Kooi, J.D.
Joannopoulos, M. Soljačić, S.G. Johnson, Optics Express 28 (2020) 33854–33868.
date_created: 2026-03-30T12:22:48Z
date_published: 2020-10-26T00:00:00Z
date_updated: 2026-04-27T07:08:18Z
day: '26'
ddc:
- '530'
doi: 10.1364/oe.403192
extern: '1'
external_id:
arxiv:
- '2007.11661'
pmid:
- '33182865'
intvolume: ' 28'
issue: '23'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1364/OE.403192
month: '10'
oa: 1
oa_version: Published Version
page: 33854-33868
pmid: 1
publication: Optics Express
publication_identifier:
issn:
- 1094-4087
publication_status: published
publisher: Optica Publishing Group
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fullwave Maxwell inverse design of axisymmetric, tunable, and multi-scale multi-wavelength
metalenses
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2020'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21642'
abstract:
- lang: eng
text: 'By codesigning a metaoptical front end in conjunction with an image‐processing
back end, we demonstrate noise sensitivity and compactness substantially superior
to either an optics‐only or a computation‐only approach, illustrated by two examples:
subwavelength imaging and reconstruction of the full polarization coherence matrices
of multiple light sources. Our end‐to‐end inverse designs couple the solution
of the full Maxwell equations—exploiting all aspects of wave physics arising in
subwavelength scatterers—with inverse‐scattering algorithms in a single large‐scale
optimization involving degrees of freedom. The resulting structures scatter light
in a way that is radically different from either a conventional lens or a random
microstructure, and suppress the noise sensitivity of the inverse‐scattering computation
by several orders of magnitude. Incorporating the full wave physics is especially
crucial for detecting spectral and polarization information that is discarded
by geometric optics and scalar diffraction theory.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Zin
full_name: Lin, Zin
last_name: Lin
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: Raphaël
full_name: Pestourie, Raphaël
last_name: Pestourie
- first_name: Marin
full_name: Soljačić, Marin
last_name: Soljačić
- first_name: Arka
full_name: Majumdar, Arka
last_name: Majumdar
- first_name: Steven G.
full_name: Johnson, Steven G.
last_name: Johnson
citation:
ama: Lin Z, Roques-Carmes C, Pestourie R, Soljačić M, Majumdar A, Johnson SG. End‐to‐end
nanophotonic inverse design for imaging and polarimetry. Nanophotonics.
2020;10(3):1177-1187. doi:10.1515/nanoph-2020-0579
apa: Lin, Z., Roques-Carmes, C., Pestourie, R., Soljačić, M., Majumdar, A., &
Johnson, S. G. (2020). End‐to‐end nanophotonic inverse design for imaging and
polarimetry. Nanophotonics. Wiley. https://doi.org/10.1515/nanoph-2020-0579
chicago: Lin, Zin, Charles Roques-Carmes, Raphaël Pestourie, Marin Soljačić, Arka
Majumdar, and Steven G. Johnson. “End‐to‐end Nanophotonic Inverse Design for Imaging
and Polarimetry.” Nanophotonics. Wiley, 2020. https://doi.org/10.1515/nanoph-2020-0579.
ieee: Z. Lin, C. Roques-Carmes, R. Pestourie, M. Soljačić, A. Majumdar, and S. G.
Johnson, “End‐to‐end nanophotonic inverse design for imaging and polarimetry,”
Nanophotonics, vol. 10, no. 3. Wiley, pp. 1177–1187, 2020.
ista: Lin Z, Roques-Carmes C, Pestourie R, Soljačić M, Majumdar A, Johnson SG. 2020.
End‐to‐end nanophotonic inverse design for imaging and polarimetry. Nanophotonics.
10(3), 1177–1187.
mla: Lin, Zin, et al. “End‐to‐end Nanophotonic Inverse Design for Imaging and Polarimetry.”
Nanophotonics, vol. 10, no. 3, Wiley, 2020, pp. 1177–87, doi:10.1515/nanoph-2020-0579.
short: Z. Lin, C. Roques-Carmes, R. Pestourie, M. Soljačić, A. Majumdar, S.G. Johnson,
Nanophotonics 10 (2020) 1177–1187.
date_created: 2026-03-30T12:22:48Z
date_published: 2020-12-23T00:00:00Z
date_updated: 2026-04-27T09:29:25Z
day: '23'
ddc:
- '530'
doi: 10.1515/nanoph-2020-0579
extern: '1'
external_id:
arxiv:
- '2006.09145'
intvolume: ' 10'
issue: '3'
keyword:
- computational imaging
- end-to-end photonic inverse design
- inverse scattering
- meta-optics
- polarimetry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1515/nanoph-2020-0579
month: '12'
oa: 1
oa_version: Published Version
page: 1177-1187
publication: Nanophotonics
publication_identifier:
eissn:
- 2192-8614
issn:
- 2192-8614
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: End‐to‐end nanophotonic inverse design for imaging and polarimetry
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 10
year: '2020'
...
---
_id: '9198'
abstract:
- lang: eng
text: "The optimization of multilayer neural networks typically leads to a solution\r\nwith
zero training error, yet the landscape can exhibit spurious local minima\r\nand
the minima can be disconnected. In this paper, we shed light on this\r\nphenomenon:
we show that the combination of stochastic gradient descent (SGD)\r\nand over-parameterization
makes the landscape of multilayer neural networks\r\napproximately connected and
thus more favorable to optimization. More\r\nspecifically, we prove that SGD solutions
are connected via a piecewise linear\r\npath, and the increase in loss along this
path vanishes as the number of\r\nneurons grows large. This result is a consequence
of the fact that the\r\nparameters found by SGD are increasingly dropout stable
as the network becomes\r\nwider. We show that, if we remove part of the neurons
(and suitably rescale the\r\nremaining ones), the change in loss is independent
of the total number of\r\nneurons, and it depends only on how many neurons are
left. Our results exhibit\r\na mild dependence on the input dimension: they are
dimension-free for two-layer\r\nnetworks and depend linearly on the dimension
for multilayer networks. We\r\nvalidate our theoretical findings with numerical
experiments for different\r\narchitectures and classification tasks."
acknowledgement: M. Mondelli was partially supported by the 2019 LopezLoreta Prize.
The authors thank Phan-Minh Nguyen for helpful discussions and the IST Distributed
Algorithms and Systems Lab for providing computational resources.
article_processing_charge: No
arxiv: 1
author:
- first_name: Aleksandr
full_name: Shevchenko, Aleksandr
id: F2B06EC2-C99E-11E9-89F0-752EE6697425
last_name: Shevchenko
- first_name: Marco
full_name: Mondelli, Marco
id: 27EB676C-8706-11E9-9510-7717E6697425
last_name: Mondelli
orcid: 0000-0002-3242-7020
citation:
ama: 'Shevchenko A, Mondelli M. Landscape connectivity and dropout stability of
SGD solutions for over-parameterized neural networks. In: Proceedings of the
37th International Conference on Machine Learning. Vol 119. ML Research Press;
2020:8773-8784.'
apa: Shevchenko, A., & Mondelli, M. (2020). Landscape connectivity and dropout
stability of SGD solutions for over-parameterized neural networks. In Proceedings
of the 37th International Conference on Machine Learning (Vol. 119, pp. 8773–8784).
ML Research Press.
chicago: Shevchenko, Aleksandr, and Marco Mondelli. “Landscape Connectivity and
Dropout Stability of SGD Solutions for Over-Parameterized Neural Networks.” In
Proceedings of the 37th International Conference on Machine Learning, 119:8773–84.
ML Research Press, 2020.
ieee: A. Shevchenko and M. Mondelli, “Landscape connectivity and dropout stability
of SGD solutions for over-parameterized neural networks,” in Proceedings of
the 37th International Conference on Machine Learning, 2020, vol. 119, pp.
8773–8784.
ista: Shevchenko A, Mondelli M. 2020. Landscape connectivity and dropout stability
of SGD solutions for over-parameterized neural networks. Proceedings of the 37th
International Conference on Machine Learning. vol. 119, 8773–8784.
mla: Shevchenko, Aleksandr, and Marco Mondelli. “Landscape Connectivity and Dropout
Stability of SGD Solutions for Over-Parameterized Neural Networks.” Proceedings
of the 37th International Conference on Machine Learning, vol. 119, ML Research
Press, 2020, pp. 8773–84.
short: A. Shevchenko, M. Mondelli, in:, Proceedings of the 37th International Conference
on Machine Learning, ML Research Press, 2020, pp. 8773–8784.
date_created: 2021-02-25T09:36:22Z
date_published: 2020-07-13T00:00:00Z
date_updated: 2026-05-19T22:30:05Z
day: '13'
ddc:
- '000'
department:
- _id: MaMo
- _id: DaAl
external_id:
arxiv:
- '1912.10095'
file:
- access_level: open_access
checksum: f042c8d4316bd87c6361aa76f1fbdbbe
content_type: application/pdf
creator: dernst
date_created: 2021-03-02T15:38:14Z
date_updated: 2021-03-02T15:38:14Z
file_id: '9217'
file_name: 2020_PMLR_Shevchenko.pdf
file_size: 5336380
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success: 1
file_date_updated: 2021-03-02T15:38:14Z
has_accepted_license: '1'
intvolume: ' 119'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 8773-8784
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
name: Prix Lopez-Loretta 2019 - Marco Mondelli
publication: Proceedings of the 37th International Conference on Machine Learning
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
related_material:
record:
- id: '17465'
relation: dissertation_contains
status: public
status: public
title: Landscape connectivity and dropout stability of SGD solutions for over-parameterized
neural networks
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 119
year: '2020'
...
---
_id: '8350'
abstract:
- lang: eng
text: "Cytoplasm is a gel-like crowded environment composed of tens of thousands
of macromolecules, organelles, cytoskeletal networks and cytosol. The structure
of the cytoplasm is thought to be highly organized and heterogeneous due to the
crowding of its constituents and their effective compartmentalization. In such
an environment, the diffusive dynamics of the molecules is very restricted, an
effect that is further amplified by clustering and anchoring of molecules. Despite
the jammed nature of the cytoplasm at the microscopic scale, large-scale reorganization
of cytoplasm is essential for important cellular functions, such as nuclear positioning
and cell division. How such mesoscale reorganization of the cytoplasm is achieved,
especially for very large cells such as oocytes or syncytial tissues that can
span hundreds of micrometers in size, has only begun to be understood.\r\nIn this
thesis, I focus on the recent advances in elucidating the molecular, cellular
and biophysical principles underlying cytoplasmic organization across different
scales, structures and species. First, I outline which of these principles have
been identified by reductionist approaches, such as in vitro reconstitution assays,
where boundary conditions and components can be modulated at ease. I then describe
how the theoretical and experimental framework established in these reduced systems
have been applied to their more complex in vivo counterparts, in particular oocytes
and embryonic syncytial structures, and discuss how such complex biological systems
can initiate symmetry breaking and establish patterning.\r\nSpecifically, I examine
an example of large-scale reorganizations taking place in zebrafish embryos, where
extensive cytoplasmic streaming leads to the segregation of cytoplasm from yolk
granules along the animal-vegetal axis of the embryo. Using biophysical experimentation
and theory, I investigate the forces underlying this process, to show that this
process does not rely on cortical actin reorganization, as previously thought,
but instead on a cell-cycle-dependent bulk actin polymerization wave traveling
from the animal to the vegetal pole of the embryo. This wave functions in segregation
by both pulling cytoplasm animally and pushing yolk granules vegetally. Cytoplasm
pulling is mediated by bulk actin network flows exerting friction forces on the
cytoplasm, while yolk granule pushing is achieved by a mechanism closely resembling
actin comet formation on yolk granules. This study defines a novel role of bulk
actin polymerization waves in embryo polarization via cytoplasmic segregation.
Lastly, I describe the cytoplasmic reorganizations taking place during zebrafish
oocyte maturation, where the initial segregation of the cytoplasm and yolk granules
occurs. Here, I demonstrate a previously uncharacterized wave of microtubule aster
formation, traveling the oocyte along the animal-vegetal axis. Further research
is required to determine the role of such microtubule structures in cytoplasmic
reorganizations therein.\r\nCollectively, these studies provide further evidence
for the coupling between cell cytoskeleton and cell cycle machinery, which can
underlie a core self-organizing mechanism for orchestrating large-scale reorganizations
in a cell-cycle-tunable manner, where the modulations of the force-generating
machinery and cytoplasmic mechanics can be harbored to fulfill cellular functions."
acknowledged_ssus:
- _id: PreCl
- _id: Bio
- _id: EM-Fac
acknowledgement: "I would have had no fish and hence no results without our wonderful
fish facility crew, Verena Mayer, Eva Schlegl, Andreas Mlak and Matthias Nowak.
Special thanks to Verena for being always happy to help and dealing with our chaotic
schedules in the lab. Danke auch, Verena, für deine Geduld, mit mir auf Deutsch
zu sprechen. Das hat mir sehr geholfen.\r\nSpecial thanks to the Bioimaging and
EM facilities at IST Austria for supporting us every day. Very special thanks would
go to Robert Hauschild for his continuous support on data analysis and also to Jack
Merrin for designing and building microfabricated chambers for the project and for
the various discussions on making zebrafish extracts."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Shayan
full_name: Shamipour, Shayan
id: 40B34FE2-F248-11E8-B48F-1D18A9856A87
last_name: Shamipour
citation:
ama: Shamipour S. Bulk actin dynamics drive phase segregation in zebrafish oocytes
. 2020. doi:10.15479/AT:ISTA:8350
apa: Shamipour, S. (2020). Bulk actin dynamics drive phase segregation in zebrafish
oocytes . Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8350
chicago: Shamipour, Shayan. “Bulk Actin Dynamics Drive Phase Segregation in Zebrafish
Oocytes .” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8350.
ieee: S. Shamipour, “Bulk actin dynamics drive phase segregation in zebrafish oocytes
,” Institute of Science and Technology Austria, 2020.
ista: Shamipour S. 2020. Bulk actin dynamics drive phase segregation in zebrafish
oocytes . Institute of Science and Technology Austria.
mla: Shamipour, Shayan. Bulk Actin Dynamics Drive Phase Segregation in Zebrafish
Oocytes . Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8350.
short: S. Shamipour, Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes
, Institute of Science and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-09-09T11:12:10Z
date_published: 2020-09-09T00:00:00Z
date_updated: 2025-09-11T07:08:52Z
day: '09'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: BjHo
- _id: CaHe
doi: 10.15479/AT:ISTA:8350
file:
- access_level: closed
checksum: 6e47871c74f85008b9876112eb3fcfa1
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: sshamip
date_created: 2020-09-09T11:06:27Z
date_updated: 2021-09-11T22:30:05Z
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file_id: '8351'
file_name: Shayan-Thesis-Final.docx
file_size: 65194814
relation: source_file
- access_level: open_access
checksum: 1b44c57f04d7e8a6fe41b1c9c55a52a3
content_type: application/pdf
creator: sshamip
date_created: 2020-09-09T11:06:13Z
date_updated: 2021-09-11T22:30:05Z
embargo: 2021-09-10
file_id: '8352'
file_name: Shayan-Thesis-Final.pdf
file_size: 23729605
relation: main_file
file_date_updated: 2021-09-11T22:30:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: None
page: '107'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7001'
relation: part_of_dissertation
status: public
- id: '6508'
relation: part_of_dissertation
status: public
- id: '735'
relation: part_of_dissertation
status: public
- id: '661'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
title: 'Bulk actin dynamics drive phase segregation in zebrafish oocytes '
type: dissertation
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7680'
abstract:
- lang: eng
text: "Proteins and their complex dynamic interactions regulate cellular mechanisms
from sensing and transducing extracellular signals, to mediating genetic responses,
and sustaining or changing cell morphology. To manipulate these protein-protein
interactions (PPIs) that govern the behavior and fate of cells, synthetically
constructed, genetically encoded tools provide the means to precisely target proteins
of interest (POIs), and control their subcellular localization and activity in
vitro and in vivo. Ideal synthetic tools react to an orthogonal cue, i.e. a trigger
that does not activate any other endogenous process, thereby allowing manipulation
of the POI alone.\r\nIn optogenetics, naturally occurring photosensory domain
from plants, algae and bacteria are re-purposed and genetically fused to POIs.
Illumination with light of a specific wavelength triggers a conformational change
that can mediate PPIs, such as dimerization or oligomerization. By using light
as a trigger, these tools can be activated with high spatial and temporal precision,
on subcellular and millisecond scales. Chemogenetic tools consist of protein domains
that recognize and bind small molecules. By genetic fusion to POIs, these domains
can mediate PPIs upon addition of their specific ligands, which are often synthetically
designed to provide highly specific interactions and exhibit good bioavailability.\r\nMost
optogenetic tools to mediate PPIs are based on well-studied photoreceptors responding
to red, blue or near-UV light, leaving a striking gap in the green band of the
visible light spectrum. Among both optogenetic and chemogenetic tools, there is
an abundance of methods to induce PPIs, but tools to disrupt them require UV illumination,
rely on covalent linkage and subsequent enzymatic cleavage or initially result
in protein clustering of unknown stoichiometry.\r\nThis work describes how the
recently structurally and photochemically characterized green-light responsive
cobalamin-binding domains (CBDs) from bacterial transcription factors were re-purposed
to function as a green-light responsive optogenetic tool. In contrast to previously
engineered optogenetic tools, CBDs do not induce PPI, but rather confer a PPI
already upon expression, which can be rapidly disrupted by illumination. This
was employed to mimic inhibition of constitutive activity of a growth factor receptor,
and successfully implement for cell signalling in mammalian cells and in vivo
to rescue development in zebrafish. This work further describes the development
and application of a chemically induced de-dimerizer (CDD) based on a recently
identified and structurally described bacterial oxyreductase. CDD forms a dimer
upon expression in absence of its cofactor, the flavin derivative F420. Safety
and of domain expression and ligand exposure are demonstrated in vitro and in
vivo in zebrafish. The system is further applied to inhibit cell signalling output
from a chimeric receptor upon F420 treatment.\r\nCBDs and CDD expand the repertoire
of synthetic tools by providing novel mechanisms of mediating PPIs, and by recognizing
previously not utilized cues. In the future, they can readily be combined with
existing synthetic tools to functionally manipulate PPIs in vitro and in vivo."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Stephanie
full_name: Kainrath, Stephanie
id: 32CFBA64-F248-11E8-B48F-1D18A9856A87
last_name: Kainrath
orcid: 0000-0002-6709-2195
citation:
ama: Kainrath S. Synthetic tools for optogenetic and chemogenetic inhibition of
cellular signals. 2020. doi:10.15479/AT:ISTA:7680
apa: Kainrath, S. (2020). Synthetic tools for optogenetic and chemogenetic inhibition
of cellular signals. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7680
chicago: Kainrath, Stephanie. “Synthetic Tools for Optogenetic and Chemogenetic
Inhibition of Cellular Signals.” Institute of Science and Technology Austria,
2020. https://doi.org/10.15479/AT:ISTA:7680.
ieee: S. Kainrath, “Synthetic tools for optogenetic and chemogenetic inhibition
of cellular signals,” Institute of Science and Technology Austria, 2020.
ista: Kainrath S. 2020. Synthetic tools for optogenetic and chemogenetic inhibition
of cellular signals. Institute of Science and Technology Austria.
mla: Kainrath, Stephanie. Synthetic Tools for Optogenetic and Chemogenetic Inhibition
of Cellular Signals. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:7680.
short: S. Kainrath, Synthetic Tools for Optogenetic and Chemogenetic Inhibition
of Cellular Signals, Institute of Science and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-04-24T16:00:51Z
date_published: 2020-04-24T00:00:00Z
date_updated: 2025-11-03T23:30:47Z
day: '24'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:7680
file:
- access_level: open_access
checksum: fb9a4468eb27be92690728e35c823796
content_type: application/pdf
creator: stgingl
date_created: 2020-04-28T11:19:21Z
date_updated: 2021-10-31T23:30:05Z
embargo: 2021-10-30
file_id: '7692'
file_name: Thesis_without-signatures_PDFA.pdf
file_size: 3268017
relation: main_file
- access_level: closed
checksum: f6c80ca97104a631a328cb79a2c53493
content_type: application/octet-stream
creator: stgingl
date_created: 2020-04-28T11:19:24Z
date_updated: 2021-10-31T23:30:05Z
embargo_to: open_access
file_id: '7693'
file_name: Thesis_without signatures.docx
file_size: 5167703
relation: source_file
file_date_updated: 2021-10-31T23:30:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: None
page: '98'
publication_identifier:
eissn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '1028'
relation: dissertation_contains
status: public
status: public
supervisor:
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
title: Synthetic tools for optogenetic and chemogenetic inhibition of cellular signals
type: dissertation
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8586'
abstract:
- lang: eng
text: Cryo-electron microscopy (cryo-EM) of cellular specimens provides insights
into biological processes and structures within a native context. However, a major
challenge still lies in the efficient and reproducible preparation of adherent
cells for subsequent cryo-EM analysis. This is due to the sensitivity of many
cellular specimens to the varying seeding and culturing conditions required for
EM experiments, the often limited amount of cellular material and also the fragility
of EM grids and their substrate. Here, we present low-cost and reusable 3D printed
grid holders, designed to improve specimen preparation when culturing challenging
cellular samples directly on grids. The described grid holders increase cell culture
reproducibility and throughput, and reduce the resources required for cell culturing.
We show that grid holders can be integrated into various cryo-EM workflows, including
micro-patterning approaches to control cell seeding on grids, and for generating
samples for cryo-focused ion beam milling and cryo-electron tomography experiments.
Their adaptable design allows for the generation of specialized grid holders customized
to a large variety of applications.
acknowledged_ssus:
- _id: ScienComp
- _id: LifeSc
- _id: Bio
- _id: EM-Fac
acknowledgement: This work was supported by the Austrian Science Fund (FWF, P33367)
to FKMS. BZ acknowledges support by the Niederösterreich Fond. This research was
also supported by the Scientific Service Units (SSU) of IST Austria through resources
provided by Scientific Computing (SciComp), the Life Science Facility (LSF), the
BioImaging Facility (BIF) and the Electron Microscopy Facility (EMF). We thank Georgi
Dimchev (IST Austria) and Sonja Jacob (Vienna Biocenter Core Facilities) for testing
our grid holders in different experimental setups and Daniel Gütl and the Kondrashov
group (IST Austria) for granting us repeated access to their 3D printers. We also
thank Jonna Alanko and the Sixt lab (IST Austria) for providing us HeLa cells, primary
BL6 mouse tail fibroblasts, NIH 3T3 fibroblasts and human telomerase immortalised
foreskin fibroblasts for our experiments. We are thankful to Ori Avinoam and William
Wan for helpful comments on the manuscript and also thank Dorotea Fracchiolla (Art&Science)
for illustrating the graphical abstract.
article_number: '107633'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Florian
full_name: Fäßler, Florian
id: 404F5528-F248-11E8-B48F-1D18A9856A87
last_name: Fäßler
orcid: 0000-0001-7149-769X
- first_name: Bettina
full_name: Zens, Bettina
id: 45FD126C-F248-11E8-B48F-1D18A9856A87
last_name: Zens
orcid: 0000-0002-9561-1239
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
citation:
ama: Fäßler F, Zens B, Hauschild R, Schur FK. 3D printed cell culture grid holders
for improved cellular specimen preparation in cryo-electron microscopy. Journal
of Structural Biology. 2020;212(3). doi:10.1016/j.jsb.2020.107633
apa: Fäßler, F., Zens, B., Hauschild, R., & Schur, F. K. (2020). 3D printed
cell culture grid holders for improved cellular specimen preparation in cryo-electron
microscopy. Journal of Structural Biology. Elsevier. https://doi.org/10.1016/j.jsb.2020.107633
chicago: Fäßler, Florian, Bettina Zens, Robert Hauschild, and Florian KM Schur.
“3D Printed Cell Culture Grid Holders for Improved Cellular Specimen Preparation
in Cryo-Electron Microscopy.” Journal of Structural Biology. Elsevier,
2020. https://doi.org/10.1016/j.jsb.2020.107633.
ieee: F. Fäßler, B. Zens, R. Hauschild, and F. K. Schur, “3D printed cell culture
grid holders for improved cellular specimen preparation in cryo-electron microscopy,”
Journal of Structural Biology, vol. 212, no. 3. Elsevier, 2020.
ista: Fäßler F, Zens B, Hauschild R, Schur FK. 2020. 3D printed cell culture grid
holders for improved cellular specimen preparation in cryo-electron microscopy.
Journal of Structural Biology. 212(3), 107633.
mla: Fäßler, Florian, et al. “3D Printed Cell Culture Grid Holders for Improved
Cellular Specimen Preparation in Cryo-Electron Microscopy.” Journal of Structural
Biology, vol. 212, no. 3, 107633, Elsevier, 2020, doi:10.1016/j.jsb.2020.107633.
short: F. Fäßler, B. Zens, R. Hauschild, F.K. Schur, Journal of Structural Biology
212 (2020).
corr_author: '1'
date_created: 2020-09-29T13:24:06Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2026-05-19T22:30:09Z
day: '01'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.1016/j.jsb.2020.107633
external_id:
isi:
- '000600997800008'
pmid:
- '32987119'
file:
- access_level: open_access
checksum: c48cbf594e84fc2f91966ffaafc0918c
content_type: application/pdf
creator: dernst
date_created: 2020-12-10T14:01:10Z
date_updated: 2020-12-10T14:01:10Z
file_id: '8937'
file_name: 2020_JourStrucBiology_Faessler.pdf
file_size: 7076870
relation: main_file
success: 1
file_date_updated: 2020-12-10T14:01:10Z
has_accepted_license: '1'
intvolume: ' 212'
isi: 1
issue: '3'
keyword:
- electron microscopy
- cryo-EM
- EM sample preparation
- 3D printing
- cell culture
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
grant_number: P33367
name: Structure and isoform diversity of the Arp2/3 complex
- _id: 059B463C-7A3F-11EA-A408-12923DDC885E
name: NÖ-Fonds Preis für die Jungforscherin des Jahres am IST Austria
publication: Journal of Structural Biology
publication_identifier:
issn:
- 1047-8477
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '14592'
relation: used_in_publication
status: public
- id: '12491'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 3D printed cell culture grid holders for improved cellular specimen preparation
in cryo-electron microscopy
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 212
year: '2020'
...
---
_id: '8434'
abstract:
- lang: eng
text: 'Efficient migration on adhesive surfaces involves the protrusion of lamellipodial
actin networks and their subsequent stabilization by nascent adhesions. The actin-binding
protein lamellipodin (Lpd) is thought to play a critical role in lamellipodium
protrusion, by delivering Ena/VASP proteins onto the growing plus ends of actin
filaments and by interacting with the WAVE regulatory complex, an activator of
the Arp2/3 complex, at the leading edge. Using B16-F1 melanoma cell lines, we
demonstrate that genetic ablation of Lpd compromises protrusion efficiency and
coincident cell migration without altering essential parameters of lamellipodia,
including their maximal rate of forward advancement and actin polymerization.
We also confirmed lamellipodia and migration phenotypes with CRISPR/Cas9-mediated
Lpd knockout Rat2 fibroblasts, excluding cell type-specific effects. Moreover,
computer-aided analysis of cell-edge morphodynamics on B16-F1 cell lamellipodia
revealed that loss of Lpd correlates with reduced temporal protrusion maintenance
as a prerequisite of nascent adhesion formation. We conclude that Lpd optimizes
protrusion and nascent adhesion formation by counteracting frequent, chaotic retraction
and membrane ruffling.This article has an associated First Person interview with
the first author of the paper. '
acknowledgement: This work was supported in part by Deutsche Forschungsgemeinschaft
(DFG)[GRK2223/1, RO2414/5-1 (to K.R.), FA350/11-1 (to M.F.) and FA330/11-1 (to J.F.)],as
well as by intramural funding from the Helmholtz Association (to T.E.B.S. andK.R.).
G.D. was additionally funded by the Austrian Science Fund (FWF) LiseMeitner Program
[M-2495]. A.C.H. and M.W. are supported by the Francis CrickInstitute, which receives
its core funding from Cancer Research UK [FC001209], theMedical Research Council
[FC001209] and the Wellcome Trust [FC001209]. M.K. issupported by the Biotechnology
and Biological Sciences Research Council [BB/F011431/1, BB/J000590/1, BB/N000226/1].
Deposited in PMC for release after 6months.
article_number: jcs239020
article_processing_charge: No
article_type: original
author:
- first_name: Georgi A
full_name: Dimchev, Georgi A
id: 38C393BE-F248-11E8-B48F-1D18A9856A87
last_name: Dimchev
orcid: 0000-0001-8370-6161
- first_name: Behnam
full_name: Amiri, Behnam
last_name: Amiri
- first_name: Ashley C.
full_name: Humphries, Ashley C.
last_name: Humphries
- first_name: Matthias
full_name: Schaks, Matthias
last_name: Schaks
- first_name: Vanessa
full_name: Dimchev, Vanessa
last_name: Dimchev
- first_name: Theresia E. B.
full_name: Stradal, Theresia E. B.
last_name: Stradal
- first_name: Jan
full_name: Faix, Jan
last_name: Faix
- first_name: Matthias
full_name: Krause, Matthias
last_name: Krause
- first_name: Michael
full_name: Way, Michael
last_name: Way
- first_name: Martin
full_name: Falcke, Martin
last_name: Falcke
- first_name: Klemens
full_name: Rottner, Klemens
last_name: Rottner
citation:
ama: Dimchev GA, Amiri B, Humphries AC, et al. Lamellipodin tunes cell migration
by stabilizing protrusions and promoting adhesion formation. Journal of Cell
Science. 2020;133(7). doi:10.1242/jcs.239020
apa: Dimchev, G. A., Amiri, B., Humphries, A. C., Schaks, M., Dimchev, V., Stradal,
T. E. B., … Rottner, K. (2020). Lamellipodin tunes cell migration by stabilizing
protrusions and promoting adhesion formation. Journal of Cell Science.
The Company of Biologists. https://doi.org/10.1242/jcs.239020
chicago: Dimchev, Georgi A, Behnam Amiri, Ashley C. Humphries, Matthias Schaks,
Vanessa Dimchev, Theresia E. B. Stradal, Jan Faix, et al. “Lamellipodin Tunes
Cell Migration by Stabilizing Protrusions and Promoting Adhesion Formation.” Journal
of Cell Science. The Company of Biologists, 2020. https://doi.org/10.1242/jcs.239020.
ieee: G. A. Dimchev et al., “Lamellipodin tunes cell migration by stabilizing
protrusions and promoting adhesion formation,” Journal of Cell Science,
vol. 133, no. 7. The Company of Biologists, 2020.
ista: Dimchev GA, Amiri B, Humphries AC, Schaks M, Dimchev V, Stradal TEB, Faix
J, Krause M, Way M, Falcke M, Rottner K. 2020. Lamellipodin tunes cell migration
by stabilizing protrusions and promoting adhesion formation. Journal of Cell Science.
133(7), jcs239020.
mla: Dimchev, Georgi A., et al. “Lamellipodin Tunes Cell Migration by Stabilizing
Protrusions and Promoting Adhesion Formation.” Journal of Cell Science,
vol. 133, no. 7, jcs239020, The Company of Biologists, 2020, doi:10.1242/jcs.239020.
short: G.A. Dimchev, B. Amiri, A.C. Humphries, M. Schaks, V. Dimchev, T.E.B. Stradal,
J. Faix, M. Krause, M. Way, M. Falcke, K. Rottner, Journal of Cell Science 133
(2020).
date_created: 2020-09-17T14:00:33Z
date_published: 2020-04-09T00:00:00Z
date_updated: 2025-04-15T07:52:13Z
day: '09'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.1242/jcs.239020
external_id:
isi:
- '000534387800005'
pmid:
- ' 32094266'
file:
- access_level: open_access
checksum: ba917e551acc4ece2884b751434df9ae
content_type: application/pdf
creator: dernst
date_created: 2020-09-17T14:07:51Z
date_updated: 2020-10-11T22:30:02Z
embargo: 2020-10-10
file_id: '8435'
file_name: 2020_JournalCellScience_Dimchev.pdf
file_size: 13493302
relation: main_file
file_date_updated: 2020-10-11T22:30:02Z
has_accepted_license: '1'
intvolume: ' 133'
isi: 1
issue: '7'
keyword:
- Cell Biology
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2674F658-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02495
name: Protein structure and function in filopodia across scales
publication: Journal of Cell Science
publication_identifier:
eissn:
- 1477-9137
issn:
- 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lamellipodin tunes cell migration by stabilizing protrusions and promoting
adhesion formation
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 133
year: '2020'
...
---
_id: '7889'
abstract:
- lang: eng
text: Autoluminescent plants engineered to express a bacterial bioluminescence gene
cluster in plastids have not been widely adopted because of low light output.
We engineered tobacco plants with a fungal bioluminescence system that converts
caffeic acid (present in all plants) into luciferin and report self-sustained
luminescence that is visible to the naked eye. Our findings could underpin development
of a suite of imaging tools for plants.
acknowledgement: "This study was designed, performed and funded by Planta LLC. We
thank K. Wood for assisting in manuscript development. Planta acknowledges support
from the Skolkovo Innovation Centre. We thank D. Bolotin and the Milaboratory (milaboratory.com)
for access to computing and storage infrastructure. We thank S. Shakhov for providing\r\nphotography
equipment. The Synthetic Biology Group is funded by the MRC London Institute of
Medical Sciences (UKRI MC-A658-5QEA0, K.S.S.). K.S.S. is supported by an Imperial
College Research Fellowship. Experiments were partially carried out using equipment
provided by the Institute of Bioorganic Chemistry of the Russian Academy\r\nof Sciences
Сore Facility (CKP IBCH; supported by the Russian Ministry of Education and Science
Grant RFMEFI62117X0018). The F.A.K. lab is supported by ERC grant agreement 771209—CharFL.
This project received funding from the European Union’s Horizon 2020 Research and
Innovation Programme under Marie Skłodowska-Curie\r\nGrant Agreement 665385. K.S.S.
acknowledges support by President’s Grant 075-15-2019-411. Design and assembly of
some of the plasmids was supported by Russian Science Foundation grant 19-74-10102.
Imaging experiments were partially supported by Russian Science Foundation grant
17-14-01169p. LC-MS/MS analyses of extracts were\r\nsupported by Russian Science
Foundation grant 16-14-00052p. Design and assembly of plasmids was partially supported
by grant 075-15-2019-1789 from the Ministry of Science and Higher Education of the
Russian Federation allocated to the Center for Precision Genome Editing and Genetic
Technologies for Biomedicine. The authors\r\nwould like to acknowledge the work
of Genomics Core Facility of the Skolkovo Institute of Science and Technology, which
performed the sequencing and bioinformatic analysis."
article_processing_charge: No
article_type: original
author:
- first_name: Tatiana
full_name: Mitiouchkina, Tatiana
last_name: Mitiouchkina
- first_name: Alexander S.
full_name: Mishin, Alexander S.
last_name: Mishin
- first_name: Louisa
full_name: Gonzalez Somermeyer, Louisa
id: 4720D23C-F248-11E8-B48F-1D18A9856A87
last_name: Gonzalez Somermeyer
orcid: 0000-0001-9139-5383
- first_name: Nadezhda M.
full_name: Markina, Nadezhda M.
last_name: Markina
- first_name: Tatiana V.
full_name: Chepurnyh, Tatiana V.
last_name: Chepurnyh
- first_name: Elena B.
full_name: Guglya, Elena B.
last_name: Guglya
- first_name: Tatiana A.
full_name: Karataeva, Tatiana A.
last_name: Karataeva
- first_name: Kseniia A.
full_name: Palkina, Kseniia A.
last_name: Palkina
- first_name: Ekaterina S.
full_name: Shakhova, Ekaterina S.
last_name: Shakhova
- first_name: Liliia I.
full_name: Fakhranurova, Liliia I.
last_name: Fakhranurova
- first_name: Sofia V.
full_name: Chekova, Sofia V.
last_name: Chekova
- first_name: Aleksandra S.
full_name: Tsarkova, Aleksandra S.
last_name: Tsarkova
- first_name: Yaroslav V.
full_name: Golubev, Yaroslav V.
last_name: Golubev
- first_name: Vadim V.
full_name: Negrebetsky, Vadim V.
last_name: Negrebetsky
- first_name: Sergey A.
full_name: Dolgushin, Sergey A.
last_name: Dolgushin
- first_name: Pavel V.
full_name: Shalaev, Pavel V.
last_name: Shalaev
- first_name: Dmitry
full_name: Shlykov, Dmitry
last_name: Shlykov
- first_name: Olesya A.
full_name: Melnik, Olesya A.
last_name: Melnik
- first_name: Victoria O.
full_name: Shipunova, Victoria O.
last_name: Shipunova
- first_name: Sergey M.
full_name: Deyev, Sergey M.
last_name: Deyev
- first_name: Andrey I.
full_name: Bubyrev, Andrey I.
last_name: Bubyrev
- first_name: Alexander S.
full_name: Pushin, Alexander S.
last_name: Pushin
- first_name: Vladimir V.
full_name: Choob, Vladimir V.
last_name: Choob
- first_name: Sergey V.
full_name: Dolgov, Sergey V.
last_name: Dolgov
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Ilia V.
full_name: Yampolsky, Ilia V.
last_name: Yampolsky
- first_name: Karen S.
full_name: Sarkisyan, Karen S.
last_name: Sarkisyan
citation:
ama: Mitiouchkina T, Mishin AS, Gonzalez Somermeyer L, et al. Plants with genetically
encoded autoluminescence. Nature Biotechnology. 2020;38:944-946. doi:10.1038/s41587-020-0500-9
apa: Mitiouchkina, T., Mishin, A. S., Gonzalez Somermeyer, L., Markina, N. M., Chepurnyh,
T. V., Guglya, E. B., … Sarkisyan, K. S. (2020). Plants with genetically encoded
autoluminescence. Nature Biotechnology. Springer Nature. https://doi.org/10.1038/s41587-020-0500-9
chicago: Mitiouchkina, Tatiana, Alexander S. Mishin, Louisa Gonzalez Somermeyer,
Nadezhda M. Markina, Tatiana V. Chepurnyh, Elena B. Guglya, Tatiana A. Karataeva,
et al. “Plants with Genetically Encoded Autoluminescence.” Nature Biotechnology.
Springer Nature, 2020. https://doi.org/10.1038/s41587-020-0500-9.
ieee: T. Mitiouchkina et al., “Plants with genetically encoded autoluminescence,”
Nature Biotechnology, vol. 38. Springer Nature, pp. 944–946, 2020.
ista: Mitiouchkina T, Mishin AS, Gonzalez Somermeyer L, Markina NM, Chepurnyh TV,
Guglya EB, Karataeva TA, Palkina KA, Shakhova ES, Fakhranurova LI, Chekova SV,
Tsarkova AS, Golubev YV, Negrebetsky VV, Dolgushin SA, Shalaev PV, Shlykov D,
Melnik OA, Shipunova VO, Deyev SM, Bubyrev AI, Pushin AS, Choob VV, Dolgov SV,
Kondrashov F, Yampolsky IV, Sarkisyan KS. 2020. Plants with genetically encoded
autoluminescence. Nature Biotechnology. 38, 944–946.
mla: Mitiouchkina, Tatiana, et al. “Plants with Genetically Encoded Autoluminescence.”
Nature Biotechnology, vol. 38, Springer Nature, 2020, pp. 944–46, doi:10.1038/s41587-020-0500-9.
short: T. Mitiouchkina, A.S. Mishin, L. Gonzalez Somermeyer, N.M. Markina, T.V.
Chepurnyh, E.B. Guglya, T.A. Karataeva, K.A. Palkina, E.S. Shakhova, L.I. Fakhranurova,
S.V. Chekova, A.S. Tsarkova, Y.V. Golubev, V.V. Negrebetsky, S.A. Dolgushin, P.V.
Shalaev, D. Shlykov, O.A. Melnik, V.O. Shipunova, S.M. Deyev, A.I. Bubyrev, A.S.
Pushin, V.V. Choob, S.V. Dolgov, F. Kondrashov, I.V. Yampolsky, K.S. Sarkisyan,
Nature Biotechnology 38 (2020) 944–946.
date_created: 2020-05-25T15:02:00Z
date_published: 2020-04-27T00:00:00Z
date_updated: 2025-04-14T07:49:47Z
day: '27'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.1038/s41587-020-0500-9
ec_funded: 1
external_id:
isi:
- '000529298800003'
pmid:
- '32341562'
file:
- access_level: open_access
checksum: 1b30467500ec6277229a875b06e196d0
content_type: application/pdf
creator: dernst
date_created: 2020-08-28T08:57:07Z
date_updated: 2021-03-02T23:30:03Z
embargo: 2021-03-01
file_id: '8316'
file_name: 2020_NatureBiotech_Mitiouchkina.pdf
file_size: 1180086
relation: main_file
file_date_updated: 2021-03-02T23:30:03Z
has_accepted_license: '1'
intvolume: ' 38'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Submitted Version
page: 944-946
pmid: 1
project:
- _id: 26580278-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771209'
name: Characterizing the fitness landscape on population and global scales
publication: Nature Biotechnology
publication_identifier:
eissn:
- 1546-1696
issn:
- 1087-0156
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41587-020-0578-0
scopus_import: '1'
status: public
title: Plants with genetically encoded autoluminescence
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 38
year: '2020'
...
---
_id: '7888'
abstract:
- lang: eng
text: Embryonic stem cell cultures are thought to self-organize into embryoid bodies,
able to undergo symmetry-breaking, germ layer specification and even morphogenesis.
Yet, it is unclear how to reconcile this remarkable self-organization capacity
with classical experiments demonstrating key roles for extrinsic biases by maternal
factors and/or extraembryonic tissues in embryogenesis. Here, we show that zebrafish
embryonic tissue explants, prepared prior to germ layer induction and lacking
extraembryonic tissues, can specify all germ layers and form a seemingly complete
mesendoderm anlage. Importantly, explant organization requires polarized inheritance
of maternal factors from dorsal-marginal regions of the blastoderm. Moreover,
induction of endoderm and head-mesoderm, which require peak Nodal-signaling levels,
is highly variable in explants, reminiscent of embryos with reduced Nodal signals
from the extraembryonic tissues. Together, these data suggest that zebrafish explants
do not undergo bona fide self-organization, but rather display features of genetically
encoded self-assembly, where intrinsic genetic programs control the emergence
of order.
article_number: e55190
article_processing_charge: No
article_type: original
author:
- first_name: Alexandra
full_name: Schauer, Alexandra
id: 30A536BA-F248-11E8-B48F-1D18A9856A87
last_name: Schauer
orcid: 0000-0001-7659-9142
- first_name: Diana C
full_name: Nunes Pinheiro, Diana C
id: 2E839F16-F248-11E8-B48F-1D18A9856A87
last_name: Nunes Pinheiro
orcid: 0000-0003-4333-7503
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Schauer A, Nunes Pinheiro DC, Hauschild R, Heisenberg C-PJ. Zebrafish embryonic
explants undergo genetically encoded self-assembly. eLife. 2020;9. doi:10.7554/elife.55190
apa: Schauer, A., Nunes Pinheiro, D. C., Hauschild, R., & Heisenberg, C.-P.
J. (2020). Zebrafish embryonic explants undergo genetically encoded self-assembly.
ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.55190
chicago: Schauer, Alexandra, Diana C Nunes Pinheiro, Robert Hauschild, and Carl-Philipp
J Heisenberg. “Zebrafish Embryonic Explants Undergo Genetically Encoded Self-Assembly.”
ELife. eLife Sciences Publications, 2020. https://doi.org/10.7554/elife.55190.
ieee: A. Schauer, D. C. Nunes Pinheiro, R. Hauschild, and C.-P. J. Heisenberg, “Zebrafish
embryonic explants undergo genetically encoded self-assembly,” eLife, vol.
9. eLife Sciences Publications, 2020.
ista: Schauer A, Nunes Pinheiro DC, Hauschild R, Heisenberg C-PJ. 2020. Zebrafish
embryonic explants undergo genetically encoded self-assembly. eLife. 9, e55190.
mla: Schauer, Alexandra, et al. “Zebrafish Embryonic Explants Undergo Genetically
Encoded Self-Assembly.” ELife, vol. 9, e55190, eLife Sciences Publications,
2020, doi:10.7554/elife.55190.
short: A. Schauer, D.C. Nunes Pinheiro, R. Hauschild, C.-P.J. Heisenberg, ELife
9 (2020).
corr_author: '1'
date_created: 2020-05-25T15:01:40Z
date_published: 2020-04-06T00:00:00Z
date_updated: 2026-05-19T22:30:13Z
day: '06'
ddc:
- '570'
department:
- _id: CaHe
- _id: Bio
doi: 10.7554/elife.55190
ec_funded: 1
external_id:
isi:
- '000531544400001'
pmid:
- '32250246'
file:
- access_level: open_access
checksum: f6aad884cf706846ae9357fcd728f8b5
content_type: application/pdf
creator: dernst
date_created: 2020-05-25T15:15:43Z
date_updated: 2020-07-14T12:48:04Z
file_id: '7890'
file_name: 2020_eLife_Schauer.pdf
file_size: 7744848
relation: main_file
file_date_updated: 2020-07-14T12:48:04Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742573'
name: Interaction and feedback between cell mechanics and fate specification in
vertebrate gastrulation
- _id: 26B1E39C-B435-11E9-9278-68D0E5697425
grant_number: '25239'
name: 'Mesendoderm specification in zebrafish: The role of extraembryonic tissues'
- _id: 26520D1E-B435-11E9-9278-68D0E5697425
grant_number: ALTF 850-2017
name: Coordination of mesendoderm cell fate specification and internalization during
zebrafish gastrulation
- _id: 266BC5CE-B435-11E9-9278-68D0E5697425
grant_number: LT000429
name: Coordination of mesendoderm fate specification and internalization during
zebrafish gastrulation
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
record:
- id: '12891'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Zebrafish embryonic explants undergo genetically encoded self-assembly
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2020'
...
---
_id: '9633'
abstract:
- lang: eng
text: The search for biologically faithful synaptic plasticity rules has resulted
in a large body of models. They are usually inspired by – and fitted to – experimental
data, but they rarely produce neural dynamics that serve complex functions. These
failures suggest that current plasticity models are still under-constrained by
existing data. Here, we present an alternative approach that uses meta-learning
to discover plausible synaptic plasticity rules. Instead of experimental data,
the rules are constrained by the functions they implement and the structure they
are meant to produce. Briefly, we parameterize synaptic plasticity rules by a
Volterra expansion and then use supervised learning methods (gradient descent
or evolutionary strategies) to minimize a problem-dependent loss function that
quantifies how effectively a candidate plasticity rule transforms an initially
random network into one with the desired function. We first validate our approach
by re-discovering previously described plasticity rules, starting at the single-neuron
level and “Oja’s rule”, a simple Hebbian plasticity rule that captures the direction
of most variability of inputs to a neuron (i.e., the first principal component).
We expand the problem to the network level and ask the framework to find Oja’s
rule together with an anti-Hebbian rule such that an initially random two-layer
firing-rate network will recover several principal components of the input space
after learning. Next, we move to networks of integrate-and-fire neurons with plastic
inhibitory afferents. We train for rules that achieve a target firing rate by
countering tuned excitation. Our algorithm discovers a specific subset of the
manifold of rules that can solve this task. Our work is a proof of principle of
an automated and unbiased approach to unveil synaptic plasticity rules that obey
biological constraints and can solve complex functions.
acknowledgement: We would like to thank Chaitanya Chintaluri, Georgia Christodoulou,
Bill Podlaski and Merima Šabanovic for useful discussions and comments. This work
was supported by a Wellcome Trust ´ Senior Research Fellowship (214316/Z/18/Z),
a BBSRC grant (BB/N019512/1), an ERC consolidator Grant (SYNAPSEEK), a Leverhulme
Trust Project Grant (RPG-2016-446), and funding from École Polytechnique, Paris.
article_processing_charge: No
author:
- first_name: Basile J
full_name: Confavreux, Basile J
id: C7610134-B532-11EA-BD9F-F5753DDC885E
last_name: Confavreux
- first_name: Friedemann
full_name: Zenke, Friedemann
last_name: Zenke
- first_name: Everton J.
full_name: Agnes, Everton J.
last_name: Agnes
- first_name: Timothy
full_name: Lillicrap, Timothy
last_name: Lillicrap
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
citation:
ama: 'Confavreux BJ, Zenke F, Agnes EJ, Lillicrap T, Vogels TP. A meta-learning
approach to (re)discover plasticity rules that carve a desired function into a
neural network. In: Advances in Neural Information Processing Systems.
Vol 33. ; 2020:16398-16408.'
apa: Confavreux, B. J., Zenke, F., Agnes, E. J., Lillicrap, T., & Vogels, T.
P. (2020). A meta-learning approach to (re)discover plasticity rules that carve
a desired function into a neural network. In Advances in Neural Information
Processing Systems (Vol. 33, pp. 16398–16408). Vancouver, Canada.
chicago: Confavreux, Basile J, Friedemann Zenke, Everton J. Agnes, Timothy Lillicrap,
and Tim P Vogels. “A Meta-Learning Approach to (Re)Discover Plasticity Rules That
Carve a Desired Function into a Neural Network.” In Advances in Neural Information
Processing Systems, 33:16398–408, 2020.
ieee: B. J. Confavreux, F. Zenke, E. J. Agnes, T. Lillicrap, and T. P. Vogels, “A
meta-learning approach to (re)discover plasticity rules that carve a desired function
into a neural network,” in Advances in Neural Information Processing Systems,
Vancouver, Canada, 2020, vol. 33, pp. 16398–16408.
ista: 'Confavreux BJ, Zenke F, Agnes EJ, Lillicrap T, Vogels TP. 2020. A meta-learning
approach to (re)discover plasticity rules that carve a desired function into a
neural network. Advances in Neural Information Processing Systems. NeurIPS: Conference
on Neural Information Processing Systems vol. 33, 16398–16408.'
mla: Confavreux, Basile J., et al. “A Meta-Learning Approach to (Re)Discover Plasticity
Rules That Carve a Desired Function into a Neural Network.” Advances in Neural
Information Processing Systems, vol. 33, 2020, pp. 16398–408.
short: B.J. Confavreux, F. Zenke, E.J. Agnes, T. Lillicrap, T.P. Vogels, in:, Advances
in Neural Information Processing Systems, 2020, pp. 16398–16408.
conference:
end_date: 2020-12-12
location: Vancouver, Canada
name: 'NeurIPS: Conference on Neural Information Processing Systems'
start_date: 2020-12-06
date_created: 2021-07-04T22:01:27Z
date_published: 2020-12-06T00:00:00Z
date_updated: 2026-05-19T22:30:15Z
day: '06'
department:
- _id: TiVo
ec_funded: 1
intvolume: ' 33'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://proceedings.neurips.cc/paper/2020/hash/bdbd5ebfde4934142c8a88e7a3796cd5-Abstract.html
month: '12'
oa: 1
oa_version: Published Version
page: 16398-16408
project:
- _id: 0aacfa84-070f-11eb-9043-d7eb2c709234
call_identifier: H2020
grant_number: '819603'
name: Learning the shape of synaptic plasticity rules for neuronal architectures
and function through machine learning.
- _id: c084a126-5a5b-11eb-8a69-d75314a70a87
grant_number: 214316/Z/18/Z
name: What’s in a memory? Spatiotemporal dynamics in strongly coupled recurrent
neuronal networks.
publication: Advances in Neural Information Processing Systems
publication_identifier:
issn:
- 1049-5258
publication_status: published
quality_controlled: '1'
related_material:
link:
- relation: is_continued_by
url: https://doi.org/10.1101/2020.10.24.353409
record:
- id: '14422'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: A meta-learning approach to (re)discover plasticity rules that carve a desired
function into a neural network
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2020'
...
---
_id: '7426'
abstract:
- lang: eng
text: This paper presents a novel abstraction technique for analyzing Lyapunov and
asymptotic stability of polyhedral switched systems. A polyhedral switched system
is a hybrid system in which the continuous dynamics is specified by polyhedral
differential inclusions, the invariants and guards are specified by polyhedral
sets and the switching between the modes do not involve reset of variables. A
finite state weighted graph abstracting the polyhedral switched system is constructed
from a finite partition of the state–space, such that the satisfaction of certain
graph conditions, such as the absence of cycles with product of weights on the
edges greater than (or equal) to 1, implies the stability of the system. However,
the graph is in general conservative and hence, the violation of the graph conditions
does not imply instability. If the analysis fails to establish stability due to
the conservativeness in the approximation, a counterexample (cycle with product
of edge weights greater than or equal to 1) indicating a potential reason for
the failure is returned. Further, a more precise approximation of the switched
system can be constructed by considering a finer partition of the state–space
in the construction of the finite weighted graph. We present experimental results
on analyzing stability of switched systems using the above method.
article_number: '100856'
article_processing_charge: No
article_type: original
author:
- first_name: Miriam
full_name: Garcia Soto, Miriam
id: 4B3207F6-F248-11E8-B48F-1D18A9856A87
last_name: Garcia Soto
orcid: 0000−0003−2936−5719
- first_name: Pavithra
full_name: Prabhakar, Pavithra
last_name: Prabhakar
citation:
ama: 'Garcia Soto M, Prabhakar P. Abstraction based verification of stability of
polyhedral switched systems. Nonlinear Analysis: Hybrid Systems. 2020;36(5).
doi:10.1016/j.nahs.2020.100856'
apa: 'Garcia Soto, M., & Prabhakar, P. (2020). Abstraction based verification
of stability of polyhedral switched systems. Nonlinear Analysis: Hybrid Systems.
Elsevier. https://doi.org/10.1016/j.nahs.2020.100856'
chicago: 'Garcia Soto, Miriam, and Pavithra Prabhakar. “Abstraction Based Verification
of Stability of Polyhedral Switched Systems.” Nonlinear Analysis: Hybrid Systems.
Elsevier, 2020. https://doi.org/10.1016/j.nahs.2020.100856.'
ieee: 'M. Garcia Soto and P. Prabhakar, “Abstraction based verification of stability
of polyhedral switched systems,” Nonlinear Analysis: Hybrid Systems, vol.
36, no. 5. Elsevier, 2020.'
ista: 'Garcia Soto M, Prabhakar P. 2020. Abstraction based verification of stability
of polyhedral switched systems. Nonlinear Analysis: Hybrid Systems. 36(5), 100856.'
mla: 'Garcia Soto, Miriam, and Pavithra Prabhakar. “Abstraction Based Verification
of Stability of Polyhedral Switched Systems.” Nonlinear Analysis: Hybrid Systems,
vol. 36, no. 5, 100856, Elsevier, 2020, doi:10.1016/j.nahs.2020.100856.'
short: 'M. Garcia Soto, P. Prabhakar, Nonlinear Analysis: Hybrid Systems 36 (2020).'
corr_author: '1'
date_created: 2020-02-02T23:00:59Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2025-04-15T06:26:15Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1016/j.nahs.2020.100856
external_id:
isi:
- '000528828600003'
file:
- access_level: open_access
checksum: 560abfddb53f9fe921b6744f59f2cfaa
content_type: application/pdf
creator: dernst
date_created: 2020-10-21T13:16:45Z
date_updated: 2022-05-16T22:30:04Z
embargo: 2022-05-15
file_id: '8688'
file_name: 2020_NAHS_GarciaSoto.pdf
file_size: 818774
relation: main_file
file_date_updated: 2022-05-16T22:30:04Z
has_accepted_license: '1'
intvolume: ' 36'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: Formal methods for the design and analysis of complex systems
publication: 'Nonlinear Analysis: Hybrid Systems'
publication_identifier:
issn:
- 1751-570X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Abstraction based verification of stability of polyhedral switched systems
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 36
year: '2020'
...