---
_id: '6944'
abstract:
- lang: eng
text: 'We study the problem of automatically detecting if a given multi-class classifier
operates outside of its specifications (out-of-specs), i.e. on input data from
a different distribution than what it was trained for. This is an important problem
to solve on the road towards creating reliable computer vision systems for real-world
applications, because the quality of a classifier’s predictions cannot be guaranteed
if it operates out-of-specs. Previously proposed methods for out-of-specs detection
make decisions on the level of single inputs. This, however, is insufficient to
achieve low false positive rate and high false negative rates at the same time.
In this work, we describe a new procedure named KS(conf), based on statistical
reasoning. Its main component is a classical Kolmogorov–Smirnov test that is applied
to the set of predicted confidence values for batches of samples. Working with
batches instead of single samples allows increasing the true positive rate without
negatively affecting the false positive rate, thereby overcoming a crucial limitation
of single sample tests. We show by extensive experiments using a variety of convolutional
network architectures and datasets that KS(conf) reliably detects out-of-specs
situations even under conditions where other tests fail. It furthermore has a
number of properties that make it an excellent candidate for practical deployment:
it is easy to implement, adds almost no overhead to the system, works with any
classifier that outputs confidence scores, and requires no a priori knowledge
about how the data distribution could change.'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Rémy
full_name: Sun, Rémy
last_name: Sun
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
citation:
ama: 'Sun R, Lampert C. KS(conf): A light-weight test if a multiclass classifier
operates outside of its specifications. International Journal of Computer Vision.
2020;128(4):970-995. doi:10.1007/s11263-019-01232-x'
apa: 'Sun, R., & Lampert, C. (2020). KS(conf): A light-weight test if a multiclass
classifier operates outside of its specifications. International Journal of
Computer Vision. Springer Nature. https://doi.org/10.1007/s11263-019-01232-x'
chicago: 'Sun, Rémy, and Christoph Lampert. “KS(Conf): A Light-Weight Test If a
Multiclass Classifier Operates Outside of Its Specifications.” International
Journal of Computer Vision. Springer Nature, 2020. https://doi.org/10.1007/s11263-019-01232-x.'
ieee: 'R. Sun and C. Lampert, “KS(conf): A light-weight test if a multiclass classifier
operates outside of its specifications,” International Journal of Computer
Vision, vol. 128, no. 4. Springer Nature, pp. 970–995, 2020.'
ista: 'Sun R, Lampert C. 2020. KS(conf): A light-weight test if a multiclass classifier
operates outside of its specifications. International Journal of Computer Vision.
128(4), 970–995.'
mla: 'Sun, Rémy, and Christoph Lampert. “KS(Conf): A Light-Weight Test If a Multiclass
Classifier Operates Outside of Its Specifications.” International Journal of
Computer Vision, vol. 128, no. 4, Springer Nature, 2020, pp. 970–95, doi:10.1007/s11263-019-01232-x.'
short: R. Sun, C. Lampert, International Journal of Computer Vision 128 (2020) 970–995.
corr_author: '1'
date_created: 2019-10-14T09:14:28Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2025-04-15T07:10:25Z
day: '01'
ddc:
- '004'
department:
- _id: ChLa
doi: 10.1007/s11263-019-01232-x
ec_funded: 1
external_id:
isi:
- '000494406800001'
file:
- access_level: open_access
checksum: 155e63edf664dcacb3bdc1c2223e606f
content_type: application/pdf
creator: dernst
date_created: 2019-11-26T10:30:02Z
date_updated: 2020-07-14T12:47:45Z
file_id: '7110'
file_name: 2019_IJCV_Sun.pdf
file_size: 1715072
relation: main_file
file_date_updated: 2020-07-14T12:47:45Z
has_accepted_license: '1'
intvolume: ' 128'
isi: 1
issue: '4'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '04'
oa: 1
oa_version: Published Version
page: 970-995
project:
- _id: 2532554C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '308036'
name: Lifelong Learning of Visual Scene Understanding
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: International Journal of Computer Vision
publication_identifier:
eissn:
- 1573-1405
issn:
- 0920-5691
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1007/s11263-019-01262-5
record:
- id: '6482'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: 'KS(conf): A light-weight test if a multiclass classifier operates outside
of its specifications'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 128
year: '2020'
...
---
_id: '6997'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Yuzhou
full_name: Zhang, Yuzhou
id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0003-2627-6956
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Zhang Y, Friml J. Auxin guides roots to avoid obstacles during gravitropic
growth. New Phytologist. 2020;225(3):1049-1052. doi:10.1111/nph.16203
apa: Zhang, Y., & Friml, J. (2020). Auxin guides roots to avoid obstacles during
gravitropic growth. New Phytologist. Wiley. https://doi.org/10.1111/nph.16203
chicago: Zhang, Yuzhou, and Jiří Friml. “Auxin Guides Roots to Avoid Obstacles during
Gravitropic Growth.” New Phytologist. Wiley, 2020. https://doi.org/10.1111/nph.16203.
ieee: Y. Zhang and J. Friml, “Auxin guides roots to avoid obstacles during gravitropic
growth,” New Phytologist, vol. 225, no. 3. Wiley, pp. 1049–1052, 2020.
ista: Zhang Y, Friml J. 2020. Auxin guides roots to avoid obstacles during gravitropic
growth. New Phytologist. 225(3), 1049–1052.
mla: Zhang, Yuzhou, and Jiří Friml. “Auxin Guides Roots to Avoid Obstacles during
Gravitropic Growth.” New Phytologist, vol. 225, no. 3, Wiley, 2020, pp.
1049–52, doi:10.1111/nph.16203.
short: Y. Zhang, J. Friml, New Phytologist 225 (2020) 1049–1052.
corr_author: '1'
date_created: 2019-11-12T11:41:32Z
date_published: 2020-02-01T00:00:00Z
date_updated: 2025-04-14T07:45:04Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1111/nph.16203
ec_funded: 1
external_id:
isi:
- '000489638800001'
pmid:
- '31603260'
file:
- access_level: open_access
checksum: cd42ffdb381fd52812b9583d4d407139
content_type: application/pdf
creator: dernst
date_created: 2020-11-18T16:42:48Z
date_updated: 2020-11-18T16:42:48Z
file_id: '8772'
file_name: 2020_NewPhytologist_Zhang.pdf
file_size: 717345
relation: main_file
success: 1
file_date_updated: 2020-11-18T16:42:48Z
has_accepted_license: '1'
intvolume: ' 225'
isi: 1
issue: '3'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 1049-1052
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
issn:
- 0028-646x
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Auxin guides roots to avoid obstacles during gravitropic growth
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 225
year: '2020'
...
---
_id: '7004'
abstract:
- lang: eng
text: We define an action of the (double of) Cohomological Hall algebra of Kontsevich
and Soibelman on the cohomology of the moduli space of spiked instantons of Nekrasov.
We identify this action with the one of the affine Yangian of gl(1). Based on
that we derive the vertex algebra at the corner Wr1,r2,r3 of Gaiotto and Rapčák.
We conjecture that our approach works for a big class of Calabi–Yau categories,
including those associated with toric Calabi–Yau 3-folds.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Miroslav
full_name: Rapcak, Miroslav
last_name: Rapcak
- first_name: Yan
full_name: Soibelman, Yan
last_name: Soibelman
- first_name: Yaping
full_name: Yang, Yaping
last_name: Yang
- first_name: Gufang
full_name: Zhao, Gufang
id: 2BC2AC5E-F248-11E8-B48F-1D18A9856A87
last_name: Zhao
citation:
ama: Rapcak M, Soibelman Y, Yang Y, Zhao G. Cohomological Hall algebras, vertex
algebras and instantons. Communications in Mathematical Physics. 2020;376:1803-1873.
doi:10.1007/s00220-019-03575-5
apa: Rapcak, M., Soibelman, Y., Yang, Y., & Zhao, G. (2020). Cohomological Hall
algebras, vertex algebras and instantons. Communications in Mathematical Physics.
Springer Nature. https://doi.org/10.1007/s00220-019-03575-5
chicago: Rapcak, Miroslav, Yan Soibelman, Yaping Yang, and Gufang Zhao. “Cohomological
Hall Algebras, Vertex Algebras and Instantons.” Communications in Mathematical
Physics. Springer Nature, 2020. https://doi.org/10.1007/s00220-019-03575-5.
ieee: M. Rapcak, Y. Soibelman, Y. Yang, and G. Zhao, “Cohomological Hall algebras,
vertex algebras and instantons,” Communications in Mathematical Physics,
vol. 376. Springer Nature, pp. 1803–1873, 2020.
ista: Rapcak M, Soibelman Y, Yang Y, Zhao G. 2020. Cohomological Hall algebras,
vertex algebras and instantons. Communications in Mathematical Physics. 376, 1803–1873.
mla: Rapcak, Miroslav, et al. “Cohomological Hall Algebras, Vertex Algebras and
Instantons.” Communications in Mathematical Physics, vol. 376, Springer
Nature, 2020, pp. 1803–73, doi:10.1007/s00220-019-03575-5.
short: M. Rapcak, Y. Soibelman, Y. Yang, G. Zhao, Communications in Mathematical
Physics 376 (2020) 1803–1873.
date_created: 2019-11-12T14:01:27Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2025-04-14T09:12:46Z
day: '01'
department:
- _id: TaHa
doi: 10.1007/s00220-019-03575-5
ec_funded: 1
external_id:
arxiv:
- '1810.10402'
isi:
- '000536255500004'
intvolume: ' 376'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1810.10402
month: '06'
oa: 1
oa_version: Preprint
page: 1803-1873
project:
- _id: 25E549F4-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '320593'
name: Arithmetic and physics of Higgs moduli spaces
publication: Communications in Mathematical Physics
publication_identifier:
eissn:
- 1432-0916
issn:
- 0010-3616
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cohomological Hall algebras, vertex algebras and instantons
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 376
year: '2020'
...
---
_id: '7033'
abstract:
- lang: eng
text: Removal of the Bax gene from mice completely protects the somas of retinal
ganglion cells (RGCs) from apoptosis following optic nerve injury. This makes
BAX a promising therapeutic target to prevent neurodegeneration. In this study,
Bax+/− mice were used to test the hypothesis that lowering the quantity of BAX
in RGCs would delay apoptosis following optic nerve injury. RGCs were damaged
by performing optic nerve crush (ONC) and then immunostaining for phospho-cJUN,
and quantitative PCR were used to monitor the status of the BAX activation mechanism
in the months following injury. The apoptotic susceptibility of injured cells
was directly tested by virally introducing GFP-BAX into Bax−/− RGCs after injury.
The competency of quiescent RGCs to reactivate their BAX activation mechanism
was tested by intravitreal injection of the JNK pathway agonist, anisomycin. Twenty-four
weeks after ONC, Bax+/− mice had significantly less cell loss in their RGC layer
than Bax+/+ mice 3 weeks after ONC. Bax+/− and Bax+/+ RGCs exhibited similar patterns
of nuclear phospho-cJUN accumulation immediately after ONC, which persisted in
Bax+/− RGCs for up to 7 weeks before abating. The transcriptional activation of
BAX-activating genes was similar in Bax+/− and Bax+/+ RGCs following ONC. Intriguingly,
cells deactivated their BAX activation mechanism between 7 and 12 weeks after
crush. Introduction of GFP-BAX into Bax−/− cells at 4 weeks after ONC showed that
these cells had a nearly normal capacity to activate this protein, but this capacity
was lost 8 weeks after crush. Collectively, these data suggest that 8–12 weeks
after crush, damaged cells no longer displayed increased susceptibility to BAX
activation relative to their naïve counterparts. In this same timeframe, retinal
glial activation and the signaling of the pro-apoptotic JNK pathway also abated.
Quiescent RGCs did not show a timely reactivation of their JNK pathway following
intravitreal injection with anisomycin. These findings demonstrate that lowering
the quantity of BAX in RGCs is neuroprotective after acute injury. Damaged RGCs
enter a quiescent state months after injury and are no longer responsive to an
apoptotic stimulus. Quiescent RGCs will require rejuvenation to reacquire functionality.
acknowledgement: This work was supported by National Eye Institute grants R01 EY012223
(RWN), R01 EY030123 (RWN), T32 EY027721 (Department of Ophthalmology and Visual
Sciences, University of Wisconsin-Madison), and a Vision Science Core grant P30
EY016665 (Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison),
an unrestricted funding grant from Research to Prevent Blindness (Department of
Ophthalmology and Visual Sciences, University of Wisconsin-Madison), the Frederick
A. Davis Endowment (RWN), and the Mr. and Mrs. George Taylor Foundation (RWN).
article_processing_charge: No
article_type: original
author:
- first_name: RJ
full_name: Donahue, RJ
last_name: Donahue
- first_name: Margaret E
full_name: Maes, Margaret E
id: 3838F452-F248-11E8-B48F-1D18A9856A87
last_name: Maes
orcid: 0000-0001-9642-1085
- first_name: JA
full_name: Grosser, JA
last_name: Grosser
- first_name: RW
full_name: Nickells, RW
last_name: Nickells
citation:
ama: Donahue R, Maes ME, Grosser J, Nickells R. BAX-depleted retinal ganglion cells
survive and become quiescent following optic nerve damage. Molecular Neurobiology.
2020;57(2):1070–1084. doi:10.1007/s12035-019-01783-7
apa: Donahue, R., Maes, M. E., Grosser, J., & Nickells, R. (2020). BAX-depleted
retinal ganglion cells survive and become quiescent following optic nerve damage.
Molecular Neurobiology. Springer Nature. https://doi.org/10.1007/s12035-019-01783-7
chicago: Donahue, RJ, Margaret E Maes, JA Grosser, and RW Nickells. “BAX-Depleted
Retinal Ganglion Cells Survive and Become Quiescent Following Optic Nerve Damage.”
Molecular Neurobiology. Springer Nature, 2020. https://doi.org/10.1007/s12035-019-01783-7.
ieee: R. Donahue, M. E. Maes, J. Grosser, and R. Nickells, “BAX-depleted retinal
ganglion cells survive and become quiescent following optic nerve damage,” Molecular
Neurobiology, vol. 57, no. 2. Springer Nature, pp. 1070–1084, 2020.
ista: Donahue R, Maes ME, Grosser J, Nickells R. 2020. BAX-depleted retinal ganglion
cells survive and become quiescent following optic nerve damage. Molecular Neurobiology.
57(2), 1070–1084.
mla: Donahue, RJ, et al. “BAX-Depleted Retinal Ganglion Cells Survive and Become
Quiescent Following Optic Nerve Damage.” Molecular Neurobiology, vol. 57,
no. 2, Springer Nature, 2020, pp. 1070–1084, doi:10.1007/s12035-019-01783-7.
short: R. Donahue, M.E. Maes, J. Grosser, R. Nickells, Molecular Neurobiology 57
(2020) 1070–1084.
date_created: 2019-11-18T14:18:39Z
date_published: 2020-02-01T00:00:00Z
date_updated: 2023-08-17T14:05:48Z
day: '01'
department:
- _id: SaSi
doi: 10.1007/s12035-019-01783-7
external_id:
isi:
- '000493754200001'
pmid:
- '31673950'
intvolume: ' 57'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035206/
month: '02'
oa: 1
oa_version: Submitted Version
page: 1070–1084
pmid: 1
publication: Molecular Neurobiology
publication_identifier:
eissn:
- 1559-1182
issn:
- 0893-7648
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: BAX-depleted retinal ganglion cells survive and become quiescent following
optic nerve damage
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 57
year: '2020'
...
---
_id: '7084'
abstract:
- lang: eng
text: The unusual correlated state that emerges in URu2Si2 below THO = 17.5 K is
known as “hidden order” because even basic characteristics of the order parameter,
such as its dimensionality (whether it has one component or two), are “hidden.”
We use resonant ultrasound spectroscopy to measure the symmetry-resolved elastic
anomalies across THO. We observe no anomalies in the shear elastic moduli, providing
strong thermodynamic evidence for a one-component order parameter. We develop
a machine learning framework that reaches this conclusion directly from the raw
data, even in a crystal that is too small for traditional resonant ultrasound.
Our result rules out a broad class of theories of hidden order based on two-component
order parameters, and constrains the nature of the fluctuations from which unconventional
superconductivity emerges at lower temperature. Our machine learning framework
is a powerful new tool for classifying the ubiquitous competing orders in correlated
electron systems.
article_number: eaaz4074
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Sayak
full_name: Ghosh, Sayak
last_name: Ghosh
- first_name: Michael
full_name: Matty, Michael
last_name: Matty
- first_name: Ryan
full_name: Baumbach, Ryan
last_name: Baumbach
- first_name: Eric D.
full_name: Bauer, Eric D.
last_name: Bauer
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
- first_name: Arkady
full_name: Shekhter, Arkady
last_name: Shekhter
- first_name: J. A.
full_name: Mydosh, J. A.
last_name: Mydosh
- first_name: Eun-Ah
full_name: Kim, Eun-Ah
last_name: Kim
- first_name: B. J.
full_name: Ramshaw, B. J.
last_name: Ramshaw
citation:
ama: Ghosh S, Matty M, Baumbach R, et al. One-component order parameter in URu2Si2
uncovered by resonant ultrasound spectroscopy and machine learning. Science
Advances. 2020;6(10). doi:10.1126/sciadv.aaz4074
apa: Ghosh, S., Matty, M., Baumbach, R., Bauer, E. D., Modic, K. A., Shekhter, A.,
… Ramshaw, B. J. (2020). One-component order parameter in URu2Si2 uncovered by
resonant ultrasound spectroscopy and machine learning. Science Advances.
American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.aaz4074
chicago: Ghosh, Sayak, Michael Matty, Ryan Baumbach, Eric D. Bauer, Kimberly A Modic,
Arkady Shekhter, J. A. Mydosh, Eun-Ah Kim, and B. J. Ramshaw. “One-Component Order
Parameter in URu2Si2 Uncovered by Resonant Ultrasound Spectroscopy and Machine
Learning.” Science Advances. American Association for the Advancement of
Science, 2020. https://doi.org/10.1126/sciadv.aaz4074.
ieee: S. Ghosh et al., “One-component order parameter in URu2Si2 uncovered
by resonant ultrasound spectroscopy and machine learning,” Science Advances,
vol. 6, no. 10. American Association for the Advancement of Science, 2020.
ista: Ghosh S, Matty M, Baumbach R, Bauer ED, Modic KA, Shekhter A, Mydosh JA, Kim
E-A, Ramshaw BJ. 2020. One-component order parameter in URu2Si2 uncovered by resonant
ultrasound spectroscopy and machine learning. Science Advances. 6(10), eaaz4074.
mla: Ghosh, Sayak, et al. “One-Component Order Parameter in URu2Si2 Uncovered by
Resonant Ultrasound Spectroscopy and Machine Learning.” Science Advances,
vol. 6, no. 10, eaaz4074, American Association for the Advancement of Science,
2020, doi:10.1126/sciadv.aaz4074.
short: S. Ghosh, M. Matty, R. Baumbach, E.D. Bauer, K.A. Modic, A. Shekhter, J.A.
Mydosh, E.-A. Kim, B.J. Ramshaw, Science Advances 6 (2020).
date_created: 2019-11-19T14:01:10Z
date_published: 2020-03-06T00:00:00Z
date_updated: 2022-08-25T15:08:41Z
day: '06'
doi: 10.1126/sciadv.aaz4074
extern: '1'
external_id:
arxiv:
- '1903.00552'
pmid:
- '32181367'
intvolume: ' 6'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1903.00552
month: '03'
oa: 1
oa_version: Preprint
pmid: 1
publication: Science Advances
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: One-component order parameter in URu2Si2 uncovered by resonant ultrasound
spectroscopy and machine learning
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2020'
...
---
_id: '71'
abstract:
- lang: eng
text: "We consider dynamical transport metrics for probability measures on discretisations
of a bounded convex domain in ℝd. These metrics are natural discrete counterparts
to the Kantorovich metric \U0001D54E2, defined using a Benamou-Brenier type formula.
Under mild assumptions we prove an asymptotic upper bound for the discrete transport
metric Wt in terms of \U0001D54E2, as the size of the mesh T tends to 0. However,
we show that the corresponding lower bound may fail in general, even on certain
one-dimensional and symmetric two-dimensional meshes. In addition, we show that
the asymptotic lower bound holds under an isotropy assumption on the mesh, which
turns out to be essentially necessary. This assumption is satisfied, e.g., for
tilings by convex regular polygons, and it implies Gromov-Hausdorff convergence
of the transport metric."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Peter
full_name: Gladbach, Peter
last_name: Gladbach
- first_name: Eva
full_name: Kopfer, Eva
last_name: Kopfer
- first_name: Jan
full_name: Maas, Jan
id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
last_name: Maas
orcid: 0000-0002-0845-1338
citation:
ama: Gladbach P, Kopfer E, Maas J. Scaling limits of discrete optimal transport.
SIAM Journal on Mathematical Analysis. 2020;52(3):2759-2802. doi:10.1137/19M1243440
apa: Gladbach, P., Kopfer, E., & Maas, J. (2020). Scaling limits of discrete
optimal transport. SIAM Journal on Mathematical Analysis. Society for Industrial
and Applied Mathematics. https://doi.org/10.1137/19M1243440
chicago: Gladbach, Peter, Eva Kopfer, and Jan Maas. “Scaling Limits of Discrete
Optimal Transport.” SIAM Journal on Mathematical Analysis. Society for
Industrial and Applied Mathematics, 2020. https://doi.org/10.1137/19M1243440.
ieee: P. Gladbach, E. Kopfer, and J. Maas, “Scaling limits of discrete optimal transport,”
SIAM Journal on Mathematical Analysis, vol. 52, no. 3. Society for Industrial
and Applied Mathematics, pp. 2759–2802, 2020.
ista: Gladbach P, Kopfer E, Maas J. 2020. Scaling limits of discrete optimal transport.
SIAM Journal on Mathematical Analysis. 52(3), 2759–2802.
mla: Gladbach, Peter, et al. “Scaling Limits of Discrete Optimal Transport.” SIAM
Journal on Mathematical Analysis, vol. 52, no. 3, Society for Industrial and
Applied Mathematics, 2020, pp. 2759–802, doi:10.1137/19M1243440.
short: P. Gladbach, E. Kopfer, J. Maas, SIAM Journal on Mathematical Analysis 52
(2020) 2759–2802.
date_created: 2018-12-11T11:44:28Z
date_published: 2020-10-01T00:00:00Z
date_updated: 2025-07-10T11:54:14Z
day: '01'
department:
- _id: JaMa
doi: 10.1137/19M1243440
external_id:
arxiv:
- '1809.01092'
isi:
- '000546975100017'
intvolume: ' 52'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1809.01092
month: '10'
oa: 1
oa_version: Preprint
page: 2759-2802
publication: SIAM Journal on Mathematical Analysis
publication_identifier:
eissn:
- 1095-7154
issn:
- 0036-1410
publication_status: published
publisher: Society for Industrial and Applied Mathematics
publist_id: '7983'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scaling limits of discrete optimal transport
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 52
year: '2020'
...
---
OA_place: publisher
_id: '7196'
abstract:
- lang: eng
text: 'In this thesis we study certain mathematical aspects of evolution. The two
primary forces that drive an evolutionary process are mutation and selection.
Mutation generates new variants in a population. Selection chooses among the variants
depending on the reproductive rates of individuals. Evolutionary processes are
intrinsically random – a new mutation that is initially present in the population
at low frequency can go extinct, even if it confers a reproductive advantage.
The overall rate of evolution is largely determined by two quantities: the probability
that an invading advantageous mutation spreads through the population (called
fixation probability) and the time until it does so (called fixation time). Both
those quantities crucially depend not only on the strength of the invading mutation
but also on the population structure. In this thesis, we aim to understand how
the underlying population structure affects the overall rate of evolution. Specifically,
we study population structures that increase the fixation probability of advantageous
mutants (called amplifiers of selection). Broadly speaking, our results are of
three different types: We present various strong amplifiers, we identify regimes
under which only limited amplification is feasible, and we propose population
structures that provide different tradeoffs between high fixation probability
and short fixation time.'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Josef
full_name: Tkadlec, Josef
id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
last_name: Tkadlec
orcid: 0000-0002-1097-9684
citation:
ama: Tkadlec J. A role of graphs in evolutionary processes. 2020. doi:10.15479/AT:ISTA:7196
apa: Tkadlec, J. (2020). A role of graphs in evolutionary processes. Institute
of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7196
chicago: Tkadlec, Josef. “A Role of Graphs in Evolutionary Processes.” Institute
of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:7196.
ieee: J. Tkadlec, “A role of graphs in evolutionary processes,” Institute of Science
and Technology Austria, 2020.
ista: Tkadlec J. 2020. A role of graphs in evolutionary processes. Institute of
Science and Technology Austria.
mla: Tkadlec, Josef. A Role of Graphs in Evolutionary Processes. Institute
of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:7196.
short: J. Tkadlec, A Role of Graphs in Evolutionary Processes, Institute of Science
and Technology Austria, 2020.
corr_author: '1'
date_created: 2019-12-20T12:26:36Z
date_published: 2020-01-12T00:00:00Z
date_updated: 2026-04-16T08:32:37Z
day: '12'
ddc:
- '519'
degree_awarded: PhD
department:
- _id: KrCh
- _id: GradSch
doi: 10.15479/AT:ISTA:7196
file:
- access_level: closed
checksum: 451f8e64b0eb26bf297644ac72bfcbe9
content_type: application/zip
creator: jtkadlec
date_created: 2020-01-12T11:49:49Z
date_updated: 2020-07-14T12:47:52Z
file_id: '7255'
file_name: thesis.zip
file_size: 21100497
relation: source_file
- access_level: open_access
checksum: d8c44cbc4f939c49a8efc9d4b8bb3985
content_type: application/pdf
creator: dernst
date_created: 2020-01-28T07:32:42Z
date_updated: 2020-07-14T12:47:52Z
file_id: '7367'
file_name: 2020_Tkadlec_Thesis.pdf
file_size: 11670983
relation: main_file
file_date_updated: 2020-07-14T12:47:52Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: '144'
publication_identifier:
eissn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '5751'
relation: dissertation_contains
status: public
- id: '7210'
relation: dissertation_contains
status: public
- id: '7212'
relation: dissertation_contains
status: public
status: public
supervisor:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
title: A role of graphs in evolutionary processes
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
_id: '7204'
abstract:
- lang: eng
text: Plant root architecture dynamically adapts to various environmental conditions,
such as salt‐containing soil. The phytohormone abscisic acid (ABA) is involved
among others also in these developmental adaptations, but the underlying molecular
mechanism remains elusive. Here, a novel branch of the ABA signaling pathway in
Arabidopsis involving PYR/PYL/RCAR (abbreviated as PYLs) receptor‐protein phosphatase
2A (PP2A) complex that acts in parallel to the canonical PYLs‐protein phosphatase
2C (PP2C) mechanism is identified. The PYLs‐PP2A signaling modulates root gravitropism
and lateral root formation through regulating phytohormone auxin transport. In
optimal conditions, PYLs ABA receptor interacts with the catalytic subunits of
PP2A, increasing their phosphatase activity and thus counteracting PINOID (PID)
kinase‐mediated phosphorylation of PIN‐FORMED (PIN) auxin transporters. By contrast,
in salt and osmotic stress conditions, ABA binds to PYLs, inhibiting the PP2A
activity, which leads to increased PIN phosphorylation and consequently modulated
directional auxin transport leading to adapted root architecture. This work reveals
an adaptive mechanism that may flexibly adjust plant root growth to withstand
saline and osmotic stresses. It occurs via the cross‐talk between the stress hormone
ABA and the versatile developmental regulator auxin.
article_number: '1901455'
article_processing_charge: No
article_type: original
author:
- first_name: Yang
full_name: Li, Yang
last_name: Li
- first_name: Yaping
full_name: Wang, Yaping
last_name: Wang
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Zhen
full_name: Li, Zhen
last_name: Li
- first_name: Zhi
full_name: Yuan, Zhi
last_name: Yuan
- first_name: Matous
full_name: Glanc, Matous
id: 1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
last_name: Glanc
orcid: 0000-0003-0619-7783
- first_name: David
full_name: Domjan, David
id: C684CD7A-257E-11EA-9B6F-D8588B4F947F
last_name: Domjan
orcid: 0000-0003-2267-106X
- first_name: Kai
full_name: Wang, Kai
last_name: Wang
- first_name: Wei
full_name: Xuan, Wei
last_name: Xuan
- first_name: Yan
full_name: Guo, Yan
last_name: Guo
- first_name: Zhizhong
full_name: Gong, Zhizhong
last_name: Gong
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Jing
full_name: Zhang, Jing
last_name: Zhang
citation:
ama: Li Y, Wang Y, Tan S, et al. Root growth adaptation is mediated by PYLs ABA
receptor-PP2A protein phosphatase complex. Advanced Science. 2020;7(3).
doi:10.1002/advs.201901455
apa: Li, Y., Wang, Y., Tan, S., Li, Z., Yuan, Z., Glanc, M., … Zhang, J. (2020).
Root growth adaptation is mediated by PYLs ABA receptor-PP2A protein phosphatase
complex. Advanced Science. Wiley. https://doi.org/10.1002/advs.201901455
chicago: Li, Yang, Yaping Wang, Shutang Tan, Zhen Li, Zhi Yuan, Matous Glanc, David
Domjan, et al. “Root Growth Adaptation Is Mediated by PYLs ABA Receptor-PP2A Protein
Phosphatase Complex.” Advanced Science. Wiley, 2020. https://doi.org/10.1002/advs.201901455.
ieee: Y. Li et al., “Root growth adaptation is mediated by PYLs ABA receptor-PP2A
protein phosphatase complex,” Advanced Science, vol. 7, no. 3. Wiley, 2020.
ista: Li Y, Wang Y, Tan S, Li Z, Yuan Z, Glanc M, Domjan D, Wang K, Xuan W, Guo
Y, Gong Z, Friml J, Zhang J. 2020. Root growth adaptation is mediated by PYLs
ABA receptor-PP2A protein phosphatase complex. Advanced Science. 7(3), 1901455.
mla: Li, Yang, et al. “Root Growth Adaptation Is Mediated by PYLs ABA Receptor-PP2A
Protein Phosphatase Complex.” Advanced Science, vol. 7, no. 3, 1901455,
Wiley, 2020, doi:10.1002/advs.201901455.
short: Y. Li, Y. Wang, S. Tan, Z. Li, Z. Yuan, M. Glanc, D. Domjan, K. Wang, W.
Xuan, Y. Guo, Z. Gong, J. Friml, J. Zhang, Advanced Science 7 (2020).
date_created: 2019-12-22T23:00:43Z
date_published: 2020-02-05T00:00:00Z
date_updated: 2023-08-17T14:13:17Z
day: '05'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1002/advs.201901455
external_id:
isi:
- '000501912800001'
pmid:
- '32042554'
file:
- access_level: open_access
checksum: 016eeab5860860af038e2da95ffe75c3
content_type: application/pdf
creator: dernst
date_created: 2020-02-24T14:29:54Z
date_updated: 2020-07-14T12:47:53Z
file_id: '7519'
file_name: 2020_AdvScience_Li.pdf
file_size: 3586924
relation: main_file
file_date_updated: 2020-07-14T12:47:53Z
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
issue: '3'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Advanced Science
publication_identifier:
eissn:
- 2198-3844
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Root growth adaptation is mediated by PYLs ABA receptor-PP2A protein phosphatase
complex
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 7
year: '2020'
...
---
_id: '7205'
abstract:
- lang: eng
text: Genetic incompatibilities contribute to reproductive isolation between many
diverging populations, but it is still unclear to what extent they play a role
if divergence happens with gene flow. In contact zones between the "Crab" and
"Wave" ecotypes of the snail Littorina saxatilis, divergent selection forms strong
barriers to gene flow, while the role of post‐zygotic barriers due to selection
against hybrids remains unclear. High embryo abortion rates in this species could
indicate the presence of such barriers. Post‐zygotic barriers might include genetic
incompatibilities (e.g. Dobzhansky–Muller incompatibilities) but also maladaptation,
both expected to be most pronounced in contact zones. In addition, embryo abortion
might reflect physiological stress on females and embryos independent of any genetic
stress. We examined all embryos of >500 females sampled outside and inside contact
zones of three populations in Sweden. Females' clutch size ranged from 0 to 1,011
embryos (mean 130 ± 123), and abortion rates varied between 0% and 100% (mean
12%). We described female genotypes by using a hybrid index based on hundreds
of SNPs differentiated between ecotypes with which we characterized female genotypes.
We also calculated female SNP heterozygosity and inversion karyotype. Clutch size
did not vary with female hybrid index, and abortion rates were only weakly related
to hybrid index in two sites but not at all in a third site. No additional variation
in abortion rate was explained by female SNP heterozygosity, but increased female
inversion heterozygosity added slightly to increased abortion. Our results show
only weak and probably biologically insignificant post‐zygotic barriers contributing
to ecotype divergence, and the high and variable abortion rates were marginally,
if at all, explained by hybrid index of females.
article_processing_charge: No
article_type: original
author:
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Zuzanna
full_name: Zagrodzka, Zuzanna
last_name: Zagrodzka
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Roger K.
full_name: Butlin, Roger K.
last_name: Butlin
citation:
ama: Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin RK. Is embryo abortion
a post-zygotic barrier to gene flow between Littorina ecotypes? Journal of
Evolutionary Biology. 2020;33(3):342-351. doi:10.1111/jeb.13570
apa: Johannesson, K., Zagrodzka, Z., Faria, R., Westram, A. M., & Butlin, R.
K. (2020). Is embryo abortion a post-zygotic barrier to gene flow between Littorina
ecotypes? Journal of Evolutionary Biology. Wiley. https://doi.org/10.1111/jeb.13570
chicago: Johannesson, Kerstin, Zuzanna Zagrodzka, Rui Faria, Anja M Westram, and
Roger K. Butlin. “Is Embryo Abortion a Post-Zygotic Barrier to Gene Flow between
Littorina Ecotypes?” Journal of Evolutionary Biology. Wiley, 2020. https://doi.org/10.1111/jeb.13570.
ieee: K. Johannesson, Z. Zagrodzka, R. Faria, A. M. Westram, and R. K. Butlin, “Is
embryo abortion a post-zygotic barrier to gene flow between Littorina ecotypes?,”
Journal of Evolutionary Biology, vol. 33, no. 3. Wiley, pp. 342–351, 2020.
ista: Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin RK. 2020. Is embryo
abortion a post-zygotic barrier to gene flow between Littorina ecotypes? Journal
of Evolutionary Biology. 33(3), 342–351.
mla: Johannesson, Kerstin, et al. “Is Embryo Abortion a Post-Zygotic Barrier to
Gene Flow between Littorina Ecotypes?” Journal of Evolutionary Biology,
vol. 33, no. 3, Wiley, 2020, pp. 342–51, doi:10.1111/jeb.13570.
short: K. Johannesson, Z. Zagrodzka, R. Faria, A.M. Westram, R.K. Butlin, Journal
of Evolutionary Biology 33 (2020) 342–351.
date_created: 2019-12-22T23:00:43Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2025-07-10T11:54:22Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/jeb.13570
external_id:
isi:
- '000500954800001'
pmid:
- '31724256'
file:
- access_level: open_access
checksum: 7534ff0839709c0c5265c12d29432f03
content_type: application/pdf
creator: dernst
date_created: 2020-09-22T09:42:18Z
date_updated: 2020-09-22T09:42:18Z
file_id: '8553'
file_name: 2020_EvolBiology_Johannesson.pdf
file_size: 885611
relation: main_file
success: 1
file_date_updated: 2020-09-22T09:42:18Z
has_accepted_license: '1'
intvolume: ' 33'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 342-351
pmid: 1
publication: Journal of Evolutionary Biology
publication_identifier:
eissn:
- 1420-9101
issn:
- 1010-061X
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '13067'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Is embryo abortion a post-zygotic barrier to gene flow between Littorina ecotypes?
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2020'
...
---
_id: '7207'
abstract:
- lang: eng
text: The hippocampus plays key roles in learning and memory and is a main target
of Alzheimer's disease (AD), which causes progressive memory impairments. Despite
numerous investigations about the processes required for the normal hippocampal
functions, the neurotransmitter receptors involved in the synaptic deficits by
which AD disables the hippocampus are not yet characterized. By combining histoblots,
western blots, immunohistochemistry and high‐resolution immunoelectron microscopic
methods for GABAB receptors, this study provides a quantitative description of
the expression and the subcellular localization of GABAB1 in the hippocampus in
a mouse model of AD at 1, 6 and 12 months of age. Western blots and histoblots
showed that the total amount of protein and the laminar expression pattern of
GABAB1 were similar in APP/PS1 mice and in age‐matched wild‐type mice. In contrast,
immunoelectron microscopic techniques showed that the subcellular localization
of GABAB1 subunit did not change significantly in APP/PS1 mice at 1 month of age,
was significantly reduced in the stratum lacunosum‐moleculare of CA1 pyramidal
cells at 6 months of age and significantly reduced at the membrane surface of
CA1 pyramidal cells at 12 months of age. This reduction of plasma membrane GABAB1
was paralleled by a significant increase of the subunit at the intracellular sites.
We further observed a decrease of membrane‐targeted GABAB receptors in axon terminals
contacting CA1 pyramidal cells. Our data demonstrate compartment‐ and age‐dependent
reduction of plasma membrane‐targeted GABAB receptors in the CA1 region of the
hippocampus, suggesting that this decrease might be enough to alter the GABAB‐mediated
synaptic transmission taking place in AD.
article_processing_charge: No
article_type: original
author:
- first_name: Alejandro
full_name: Martín-Belmonte, Alejandro
last_name: Martín-Belmonte
- first_name: Carolina
full_name: Aguado, Carolina
last_name: Aguado
- first_name: Rocío
full_name: Alfaro-Ruíz, Rocío
last_name: Alfaro-Ruíz
- first_name: Ana Esther
full_name: Moreno-Martínez, Ana Esther
last_name: Moreno-Martínez
- first_name: Luis
full_name: De La Ossa, Luis
last_name: De La Ossa
- first_name: José
full_name: Martínez-Hernández, José
last_name: Martínez-Hernández
- first_name: Alain
full_name: Buisson, Alain
last_name: Buisson
- first_name: Simon
full_name: Früh, Simon
last_name: Früh
- first_name: Bernhard
full_name: Bettler, Bernhard
last_name: Bettler
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
citation:
ama: Martín-Belmonte A, Aguado C, Alfaro-Ruíz R, et al. Reduction in the neuronal
surface of post and presynaptic GABA>B< receptors in the hippocampus in
a mouse model of Alzheimer’s disease. Brain Pathology. 2020;30(3):554-575.
doi:10.1111/bpa.12802
apa: Martín-Belmonte, A., Aguado, C., Alfaro-Ruíz, R., Moreno-Martínez, A. E., De
La Ossa, L., Martínez-Hernández, J., … Luján, R. (2020). Reduction in the neuronal
surface of post and presynaptic GABA>B< receptors in the hippocampus in
a mouse model of Alzheimer’s disease. Brain Pathology. Wiley. https://doi.org/10.1111/bpa.12802
chicago: Martín-Belmonte, Alejandro, Carolina Aguado, Rocío Alfaro-Ruíz, Ana Esther
Moreno-Martínez, Luis De La Ossa, José Martínez-Hernández, Alain Buisson, et al.
“Reduction in the Neuronal Surface of Post and Presynaptic GABA>B< Receptors
in the Hippocampus in a Mouse Model of Alzheimer’s Disease.” Brain Pathology.
Wiley, 2020. https://doi.org/10.1111/bpa.12802.
ieee: A. Martín-Belmonte et al., “Reduction in the neuronal surface of post
and presynaptic GABA>B< receptors in the hippocampus in a mouse model
of Alzheimer’s disease,” Brain Pathology, vol. 30, no. 3. Wiley, pp. 554–575,
2020.
ista: Martín-Belmonte A, Aguado C, Alfaro-Ruíz R, Moreno-Martínez AE, De La Ossa
L, Martínez-Hernández J, Buisson A, Früh S, Bettler B, Shigemoto R, Fukazawa Y,
Luján R. 2020. Reduction in the neuronal surface of post and presynaptic GABA>B<
receptors in the hippocampus in a mouse model of Alzheimer’s disease. Brain Pathology.
30(3), 554–575.
mla: Martín-Belmonte, Alejandro, et al. “Reduction in the Neuronal Surface of Post
and Presynaptic GABA>B< Receptors in the Hippocampus in a Mouse Model
of Alzheimer’s Disease.” Brain Pathology, vol. 30, no. 3, Wiley, 2020,
pp. 554–75, doi:10.1111/bpa.12802.
short: A. Martín-Belmonte, C. Aguado, R. Alfaro-Ruíz, A.E. Moreno-Martínez, L. De
La Ossa, J. Martínez-Hernández, A. Buisson, S. Früh, B. Bettler, R. Shigemoto,
Y. Fukazawa, R. Luján, Brain Pathology 30 (2020) 554–575.
date_created: 2019-12-22T23:00:43Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2025-07-10T11:54:22Z
day: '01'
ddc:
- '570'
department:
- _id: RySh
doi: 10.1111/bpa.12802
ec_funded: 1
external_id:
isi:
- '000502270900001'
pmid:
- '31729777'
file:
- access_level: open_access
checksum: 549cc1b18f638a21d17a939ba5563fa9
content_type: application/pdf
creator: dernst
date_created: 2020-09-22T09:47:19Z
date_updated: 2020-09-22T09:47:19Z
file_id: '8554'
file_name: 2020_BrainPathology_MartinBelmonte.pdf
file_size: 4220935
relation: main_file
success: 1
file_date_updated: 2020-09-22T09:47:19Z
has_accepted_license: '1'
intvolume: ' 30'
isi: 1
issue: '3'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 554-575
pmid: 1
project:
- _id: 25CBA828-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '720270'
name: Human Brain Project Specific Grant Agreement 1
- _id: 26436750-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '785907'
name: Human Brain Project Specific Grant Agreement 2
publication: Brain Pathology
publication_identifier:
eissn:
- 1750-3639
issn:
- 1015-6305
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reduction in the neuronal surface of post and presynaptic GABA>B< receptors
in the hippocampus in a mouse model of Alzheimer's disease
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2020'
...
---
_id: '7212'
abstract:
- lang: eng
text: The fixation probability of a single mutant invading a population of residents
is among the most widely-studied quantities in evolutionary dynamics. Amplifiers
of natural selection are population structures that increase the fixation probability
of advantageous mutants, compared to well-mixed populations. Extensive studies
have shown that many amplifiers exist for the Birth-death Moran process, some
of them substantially increasing the fixation probability or even guaranteeing
fixation in the limit of large population size. On the other hand, no amplifiers
are known for the death-Birth Moran process, and computer-assisted exhaustive
searches have failed to discover amplification. In this work we resolve this disparity,
by showing that any amplification under death-Birth updating is necessarily bounded
and transient. Our boundedness result states that even if a population structure
does amplify selection, the resulting fixation probability is close to that of
the well-mixed population. Our transience result states that for any population
structure there exists a threshold r⋆ such that the population structure ceases
to amplify selection if the mutant fitness advantage r is larger than r⋆. Finally,
we also extend the above results to δ-death-Birth updating, which is a combination
of Birth-death and death-Birth updating. On the positive side, we identify population
structures that maintain amplification for a wide range of values r and δ. These
results demonstrate that amplification of natural selection depends on the specific
mechanisms of the evolutionary process.
article_number: e1007494
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Josef
full_name: Tkadlec, Josef
id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
last_name: Tkadlec
orcid: 0000-0002-1097-9684
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin A.
full_name: Nowak, Martin A.
last_name: Nowak
citation:
ama: Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. Limits on amplifiers of
natural selection under death-Birth updating. PLoS computational biology.
2020;16. doi:10.1371/journal.pcbi.1007494
apa: Tkadlec, J., Pavlogiannis, A., Chatterjee, K., & Nowak, M. A. (2020). Limits
on amplifiers of natural selection under death-Birth updating. PLoS Computational
Biology. Public Library of Science. https://doi.org/10.1371/journal.pcbi.1007494
chicago: Tkadlec, Josef, Andreas Pavlogiannis, Krishnendu Chatterjee, and Martin
A. Nowak. “Limits on Amplifiers of Natural Selection under Death-Birth Updating.”
PLoS Computational Biology. Public Library of Science, 2020. https://doi.org/10.1371/journal.pcbi.1007494.
ieee: J. Tkadlec, A. Pavlogiannis, K. Chatterjee, and M. A. Nowak, “Limits on amplifiers
of natural selection under death-Birth updating,” PLoS computational biology,
vol. 16. Public Library of Science, 2020.
ista: Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. 2020. Limits on amplifiers
of natural selection under death-Birth updating. PLoS computational biology. 16,
e1007494.
mla: Tkadlec, Josef, et al. “Limits on Amplifiers of Natural Selection under Death-Birth
Updating.” PLoS Computational Biology, vol. 16, e1007494, Public Library
of Science, 2020, doi:10.1371/journal.pcbi.1007494.
short: J. Tkadlec, A. Pavlogiannis, K. Chatterjee, M.A. Nowak, PLoS Computational
Biology 16 (2020).
date_created: 2019-12-23T13:45:11Z
date_published: 2020-01-17T00:00:00Z
date_updated: 2026-04-16T08:32:38Z
day: '17'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1371/journal.pcbi.1007494
ec_funded: 1
external_id:
arxiv:
- '1906.02785'
isi:
- '000510916500025'
file:
- access_level: open_access
checksum: ce32ee2d2f53aed832f78bbd47e882df
content_type: application/pdf
creator: dernst
date_created: 2020-02-03T07:32:42Z
date_updated: 2020-07-14T12:47:53Z
file_id: '7441'
file_name: 2020_PlosCompBio_Tkadlec.pdf
file_size: 1817531
relation: main_file
file_date_updated: 2020-07-14T12:47:53Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
publication: PLoS computational biology
publication_identifier:
eissn:
- 1553-7358
issn:
- 1553-734X
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
record:
- id: '7196'
relation: part_of_dissertation
status: public
scopus_import: '1'
status: public
title: Limits on amplifiers of natural selection under death-Birth updating
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 16
year: '2020'
...
---
_id: '7213'
abstract:
- lang: eng
text: Persistent homology is a powerful tool in Topological Data Analysis (TDA)
to capture the topological properties of data succinctly at different spatial
resolutions. For graphical data, the shape, and structure of the neighborhood
of individual data items (nodes) are an essential means of characterizing their
properties. We propose the use of persistent homology methods to capture structural
and topological properties of graphs and use it to address the problem of link
prediction. We achieve encouraging results on nine different real-world datasets
that attest to the potential of persistent homology-based methods for network
analysis.
alternative_title:
- SCI
article_processing_charge: No
author:
- first_name: Sumit
full_name: Bhatia, Sumit
last_name: Bhatia
- first_name: Bapi
full_name: Chatterjee, Bapi
id: 3C41A08A-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-2742-4028
- first_name: Deepak
full_name: Nathani, Deepak
last_name: Nathani
- first_name: Manohar
full_name: Kaul, Manohar
last_name: Kaul
citation:
ama: 'Bhatia S, Chatterjee B, Nathani D, Kaul M. A persistent homology perspective
to the link prediction problem. In: Complex Networks and Their Applications
VIII. Vol 881. Springer Nature; 2020:27-39. doi:10.1007/978-3-030-36687-2_3'
apa: 'Bhatia, S., Chatterjee, B., Nathani, D., & Kaul, M. (2020). A persistent
homology perspective to the link prediction problem. In Complex Networks and
their applications VIII (Vol. 881, pp. 27–39). Lisbon, Portugal: Springer
Nature. https://doi.org/10.1007/978-3-030-36687-2_3'
chicago: Bhatia, Sumit, Bapi Chatterjee, Deepak Nathani, and Manohar Kaul. “A Persistent
Homology Perspective to the Link Prediction Problem.” In Complex Networks and
Their Applications VIII, 881:27–39. Springer Nature, 2020. https://doi.org/10.1007/978-3-030-36687-2_3.
ieee: S. Bhatia, B. Chatterjee, D. Nathani, and M. Kaul, “A persistent homology
perspective to the link prediction problem,” in Complex Networks and their
applications VIII, Lisbon, Portugal, 2020, vol. 881, pp. 27–39.
ista: 'Bhatia S, Chatterjee B, Nathani D, Kaul M. 2020. A persistent homology perspective
to the link prediction problem. Complex Networks and their applications VIII.
COMPLEX: International Conference on Complex Networks and their Applications,
SCI, vol. 881, 27–39.'
mla: Bhatia, Sumit, et al. “A Persistent Homology Perspective to the Link Prediction
Problem.” Complex Networks and Their Applications VIII, vol. 881, Springer
Nature, 2020, pp. 27–39, doi:10.1007/978-3-030-36687-2_3.
short: S. Bhatia, B. Chatterjee, D. Nathani, M. Kaul, in:, Complex Networks and
Their Applications VIII, Springer Nature, 2020, pp. 27–39.
conference:
end_date: 2019-12-12
location: Lisbon, Portugal
name: 'COMPLEX: International Conference on Complex Networks and their Applications'
start_date: 2019-12-10
date_created: 2019-12-29T23:00:45Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2025-07-10T11:54:23Z
day: '01'
ddc:
- '004'
department:
- _id: DaAl
doi: 10.1007/978-3-030-36687-2_3
ec_funded: 1
external_id:
isi:
- '000843927300003'
file:
- access_level: open_access
checksum: 8951f094c8c7dae9ff8db885199bc296
content_type: application/pdf
creator: bchatter
date_created: 2020-10-08T08:16:48Z
date_updated: 2020-10-08T08:16:48Z
file_id: '8625'
file_name: main.pdf
file_size: 310598
relation: main_file
success: 1
file_date_updated: 2020-10-08T08:16:48Z
has_accepted_license: '1'
intvolume: ' 881'
isi: 1
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 27-39
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Complex Networks and their applications VIII
publication_identifier:
eissn:
- 1860-9503
isbn:
- '9783030366865'
issn:
- 1860-949X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: A persistent homology perspective to the link prediction problem
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 881
year: '2020'
...
---
_id: '7224'
abstract:
- lang: eng
text: 'Habitat loss is one of the key drivers of the ongoing decline of biodiversity.
However, ecologists still argue about how fragmentation of habitat (independent
of habitat loss) affects species richness. The recently proposed habitat amount
hypothesis posits that species richness only depends on the total amount of habitat
in a local landscape. In contrast, empirical studies report contrasting patterns:
some find positive and others negative effects of fragmentation per se on species
richness. To explain this apparent disparity, we devise a stochastic, spatially
explicit model of competitive species communities in heterogeneous habitats. The
model shows that habitat loss and fragmentation have complex effects on species
diversity in competitive communities. When the total amount of habitat is large,
fragmentation per se tends to increase species diversity, but if the total amount
of habitat is small, the situation is reversed: fragmentation per se decreases
species diversity.'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Joel
full_name: Rybicki, Joel
id: 334EFD2E-F248-11E8-B48F-1D18A9856A87
last_name: Rybicki
orcid: 0000-0002-6432-6646
- first_name: Nerea
full_name: Abrego, Nerea
last_name: Abrego
- first_name: Otso
full_name: Ovaskainen, Otso
last_name: Ovaskainen
citation:
ama: Rybicki J, Abrego N, Ovaskainen O. Habitat fragmentation and species diversity
in competitive communities. Ecology Letters. 2020;23(3):506-517. doi:10.1111/ele.13450
apa: Rybicki, J., Abrego, N., & Ovaskainen, O. (2020). Habitat fragmentation
and species diversity in competitive communities. Ecology Letters. Wiley.
https://doi.org/10.1111/ele.13450
chicago: Rybicki, Joel, Nerea Abrego, and Otso Ovaskainen. “Habitat Fragmentation
and Species Diversity in Competitive Communities.” Ecology Letters. Wiley,
2020. https://doi.org/10.1111/ele.13450.
ieee: J. Rybicki, N. Abrego, and O. Ovaskainen, “Habitat fragmentation and species
diversity in competitive communities,” Ecology Letters, vol. 23, no. 3.
Wiley, pp. 506–517, 2020.
ista: Rybicki J, Abrego N, Ovaskainen O. 2020. Habitat fragmentation and species
diversity in competitive communities. Ecology Letters. 23(3), 506–517.
mla: Rybicki, Joel, et al. “Habitat Fragmentation and Species Diversity in Competitive
Communities.” Ecology Letters, vol. 23, no. 3, Wiley, 2020, pp. 506–17,
doi:10.1111/ele.13450.
short: J. Rybicki, N. Abrego, O. Ovaskainen, Ecology Letters 23 (2020) 506–517.
corr_author: '1'
date_created: 2020-01-04T11:04:30Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2025-06-12T07:28:52Z
day: '01'
ddc:
- '000'
department:
- _id: DaAl
doi: 10.1111/ele.13450
ec_funded: 1
external_id:
isi:
- '000503625200001'
pmid:
- '31863571'
file:
- access_level: open_access
checksum: 372f67f2744f4b6049e9778364766c22
content_type: application/pdf
creator: dernst
date_created: 2020-02-14T12:02:50Z
date_updated: 2020-07-14T12:47:54Z
file_id: '7486'
file_name: 2020_EcologyLetters_Rybicki.pdf
file_size: 3005474
relation: main_file
file_date_updated: 2020-07-14T12:47:54Z
has_accepted_license: '1'
intvolume: ' 23'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 506-517
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 26A5D39A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '840605'
name: Coordination in constrained and natural distributed systems
publication: Ecology Letters
publication_identifier:
eissn:
- 1461-0248
issn:
- 1461-023X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Habitat fragmentation and species diversity in competitive communities
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2020'
...
---
_id: '7234'
abstract:
- lang: eng
text: T lymphocytes utilize amoeboid migration to navigate effectively within complex
microenvironments. The precise rearrangement of the actin cytoskeleton required
for cellular forward propulsion is mediated by actin regulators, including the
actin‐related protein 2/3 (Arp2/3) complex, a macromolecular machine that nucleates
branched actin filaments at the leading edge. The consequences of modulating Arp2/3
activity on the biophysical properties of the actomyosin cortex and downstream
T cell function are incompletely understood. We report that even a moderate decrease
of Arp3 levels in T cells profoundly affects actin cortex integrity. Reduction
in total F‐actin content leads to reduced cortical tension and disrupted lamellipodia
formation. Instead, in Arp3‐knockdown cells, the motility mode is dominated by
blebbing migration characterized by transient, balloon‐like protrusions at the
leading edge. Although this migration mode seems to be compatible with interstitial
migration in three‐dimensional environments, diminished locomotion kinetics and
impaired cytotoxicity interfere with optimal T cell function. These findings define
the importance of finely tuned, Arp2/3‐dependent mechanophysical membrane integrity
in cytotoxic effector T lymphocyte activities.
article_processing_charge: No
article_type: original
author:
- first_name: Peyman
full_name: Obeidy, Peyman
last_name: Obeidy
- first_name: Lining A.
full_name: Ju, Lining A.
last_name: Ju
- first_name: Stefan H.
full_name: Oehlers, Stefan H.
last_name: Oehlers
- first_name: Nursafwana S.
full_name: Zulkhernain, Nursafwana S.
last_name: Zulkhernain
- first_name: Quintin
full_name: Lee, Quintin
last_name: Lee
- first_name: Jorge L.
full_name: Galeano Niño, Jorge L.
last_name: Galeano Niño
- first_name: Rain Y.Q.
full_name: Kwan, Rain Y.Q.
last_name: Kwan
- first_name: Shweta
full_name: Tikoo, Shweta
last_name: Tikoo
- first_name: Lois L.
full_name: Cavanagh, Lois L.
last_name: Cavanagh
- first_name: Paulus
full_name: Mrass, Paulus
last_name: Mrass
- first_name: Adam J.L.
full_name: Cook, Adam J.L.
last_name: Cook
- first_name: Shaun P.
full_name: Jackson, Shaun P.
last_name: Jackson
- first_name: Maté
full_name: Biro, Maté
last_name: Biro
- first_name: Ben
full_name: Roediger, Ben
last_name: Roediger
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Wolfgang
full_name: Weninger, Wolfgang
last_name: Weninger
citation:
ama: Obeidy P, Ju LA, Oehlers SH, et al. Partial loss of actin nucleator actin-related
protein 2/3 activity triggers blebbing in primary T lymphocytes. Immunology
and Cell Biology. 2020;98(2):93-113. doi:10.1111/imcb.12304
apa: Obeidy, P., Ju, L. A., Oehlers, S. H., Zulkhernain, N. S., Lee, Q., Galeano
Niño, J. L., … Weninger, W. (2020). Partial loss of actin nucleator actin-related
protein 2/3 activity triggers blebbing in primary T lymphocytes. Immunology
and Cell Biology. Wiley. https://doi.org/10.1111/imcb.12304
chicago: Obeidy, Peyman, Lining A. Ju, Stefan H. Oehlers, Nursafwana S. Zulkhernain,
Quintin Lee, Jorge L. Galeano Niño, Rain Y.Q. Kwan, et al. “Partial Loss of Actin
Nucleator Actin-Related Protein 2/3 Activity Triggers Blebbing in Primary T Lymphocytes.”
Immunology and Cell Biology. Wiley, 2020. https://doi.org/10.1111/imcb.12304.
ieee: P. Obeidy et al., “Partial loss of actin nucleator actin-related protein
2/3 activity triggers blebbing in primary T lymphocytes,” Immunology and Cell
Biology, vol. 98, no. 2. Wiley, pp. 93–113, 2020.
ista: Obeidy P, Ju LA, Oehlers SH, Zulkhernain NS, Lee Q, Galeano Niño JL, Kwan
RYQ, Tikoo S, Cavanagh LL, Mrass P, Cook AJL, Jackson SP, Biro M, Roediger B,
Sixt MK, Weninger W. 2020. Partial loss of actin nucleator actin-related protein
2/3 activity triggers blebbing in primary T lymphocytes. Immunology and Cell Biology.
98(2), 93–113.
mla: Obeidy, Peyman, et al. “Partial Loss of Actin Nucleator Actin-Related Protein
2/3 Activity Triggers Blebbing in Primary T Lymphocytes.” Immunology and Cell
Biology, vol. 98, no. 2, Wiley, 2020, pp. 93–113, doi:10.1111/imcb.12304.
short: P. Obeidy, L.A. Ju, S.H. Oehlers, N.S. Zulkhernain, Q. Lee, J.L. Galeano
Niño, R.Y.Q. Kwan, S. Tikoo, L.L. Cavanagh, P. Mrass, A.J.L. Cook, S.P. Jackson,
M. Biro, B. Roediger, M.K. Sixt, W. Weninger, Immunology and Cell Biology 98 (2020)
93–113.
date_created: 2020-01-05T23:00:48Z
date_published: 2020-02-01T00:00:00Z
date_updated: 2026-04-02T14:29:00Z
day: '01'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1111/imcb.12304
external_id:
isi:
- '000503885600001'
pmid:
- '31698518'
file:
- access_level: open_access
checksum: c389477b4b52172ef76afff8a06c6775
content_type: application/pdf
creator: dernst
date_created: 2020-11-19T11:22:33Z
date_updated: 2020-11-19T11:22:33Z
file_id: '8775'
file_name: 2020_ImmunologyCellBio_Obeidy.pdf
file_size: 8569945
relation: main_file
success: 1
file_date_updated: 2020-11-19T11:22:33Z
has_accepted_license: '1'
intvolume: ' 98'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 93-113
pmid: 1
publication: Immunology and Cell Biology
publication_identifier:
eissn:
- 1440-1711
issn:
- 0818-9641
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Partial loss of actin nucleator actin-related protein 2/3 activity triggers
blebbing in primary T lymphocytes
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 98
year: '2020'
...
---
_id: '7235'
abstract:
- lang: eng
text: We consider the Fröhlich model of a polaron, and show that its effective mass
diverges in thestrong coupling limit.
acknowledgement: Open access funding provided by Institute of Science and Technology
(IST Austria). Financial support through the European Research Council (ERC) under
the European Union’s Horizon 2020 research and innovation programme (Grant Agreement
No. 694227; R.S.) is gratefully acknowledged.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Elliott H.
full_name: Lieb, Elliott H.
last_name: Lieb
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Lieb EH, Seiringer R. Divergence of the effective mass of a polaron in the
strong coupling limit. Journal of Statistical Physics. 2020;180:23-33.
doi:10.1007/s10955-019-02322-3
apa: Lieb, E. H., & Seiringer, R. (2020). Divergence of the effective mass of
a polaron in the strong coupling limit. Journal of Statistical Physics.
Springer Nature. https://doi.org/10.1007/s10955-019-02322-3
chicago: Lieb, Elliott H., and Robert Seiringer. “Divergence of the Effective Mass
of a Polaron in the Strong Coupling Limit.” Journal of Statistical Physics.
Springer Nature, 2020. https://doi.org/10.1007/s10955-019-02322-3.
ieee: E. H. Lieb and R. Seiringer, “Divergence of the effective mass of a polaron
in the strong coupling limit,” Journal of Statistical Physics, vol. 180.
Springer Nature, pp. 23–33, 2020.
ista: Lieb EH, Seiringer R. 2020. Divergence of the effective mass of a polaron
in the strong coupling limit. Journal of Statistical Physics. 180, 23–33.
mla: Lieb, Elliott H., and Robert Seiringer. “Divergence of the Effective Mass of
a Polaron in the Strong Coupling Limit.” Journal of Statistical Physics,
vol. 180, Springer Nature, 2020, pp. 23–33, doi:10.1007/s10955-019-02322-3.
short: E.H. Lieb, R. Seiringer, Journal of Statistical Physics 180 (2020) 23–33.
corr_author: '1'
date_created: 2020-01-07T09:42:03Z
date_published: 2020-09-01T00:00:00Z
date_updated: 2025-04-14T07:27:01Z
day: '01'
ddc:
- '510'
- '530'
department:
- _id: RoSe
doi: 10.1007/s10955-019-02322-3
ec_funded: 1
external_id:
isi:
- '000556199700003'
file:
- access_level: open_access
checksum: 1e67bee6728592f7bdcea2ad2d9366dc
content_type: application/pdf
creator: dernst
date_created: 2020-11-19T11:13:55Z
date_updated: 2020-11-19T11:13:55Z
file_id: '8774'
file_name: 2020_JourStatPhysics_Lieb.pdf
file_size: 279749
relation: main_file
success: 1
file_date_updated: 2020-11-19T11:13:55Z
has_accepted_license: '1'
intvolume: ' 180'
isi: 1
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 23-33
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
publication: Journal of Statistical Physics
publication_identifier:
eissn:
- 1572-9613
issn:
- 0022-4715
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Divergence of the effective mass of a polaron in the strong coupling limit
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 180
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
_id: '7236'
abstract:
- lang: eng
text: The biotic interactions hypothesis posits that biotic interactions are more
important drivers of adaptation closer to the equator, evidenced by “stronger”
contemporary interactions (e.g. greater interaction rates) and/or patterns of
trait evolution consistent with a history of stronger interactions. Support for
the hypothesis is mixed, but few studies span tropical and temperate regions while
experimentally controlling for evolutionary history. Here, we integrate field
observations and common garden experiments to quantify the relative importance
of pollination and herbivory in a pair of tropical‐temperate congeneric perennial
herbs. Phytolacca rivinoides and P. americana are pioneer species native to the
Neotropics and the eastern USA, respectively. We compared plant‐pollinator and
plant‐herbivore interactions between three tropical populations of P. rivinoides
from Costa Rica and three temperate populations of P. americana from its northern
range edge in Michigan and Ohio. For some metrics of interaction importance, we
also included three subtropical populations of P. americana from its southern
range edge in Florida. This approach confounds species and region but allows us,
uniquely, to measure complementary proxies of interaction importance across a
tropical‐temperate range in one system. To test the prediction that lower‐latitude
plants are more reliant on insect pollinators, we quantified floral display and
reward, insect visitation rates, and self‐pollination ability (autogamy). To test
the prediction that lower‐latitude plants experience more herbivore pressure,
we quantified herbivory rates, herbivore abundance, and leaf palatability. We
found evidence supporting the biotic interactions hypothesis for most comparisons
between P. rivinoides and north‐temperate P. americana (floral display, insect
visitation, autogamy, herbivory, herbivore abundance, and young‐leaf palatability).
Results for subtropical P. americana populations, however, were typically not
intermediate between P. rivinoides and north‐temperate P. americana, as would
be predicted by a linear latitudinal gradient in interaction importance. Subtropical
young‐leaf palatability was intermediate, but subtropical mature leaves were the
least palatable, and pollination‐related traits did not differ between temperate
and subtropical regions. These nonlinear patterns of interaction importance suggest
future work to relate interaction importance to climatic or biotic thresholds.
In sum, we found that the biotic interactions hypothesis was more consistently
supported at the larger spatial scale of our study.
article_number: e01397
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Carina
full_name: Baskett, Carina
id: 3B4A7CE2-F248-11E8-B48F-1D18A9856A87
last_name: Baskett
orcid: 0000-0002-7354-8574
- first_name: Lucy
full_name: Schroeder, Lucy
last_name: Schroeder
- first_name: Marjorie G.
full_name: Weber, Marjorie G.
last_name: Weber
- first_name: Douglas W.
full_name: Schemske, Douglas W.
last_name: Schemske
citation:
ama: Baskett C, Schroeder L, Weber MG, Schemske DW. Multiple metrics of latitudinal
patterns in insect pollination and herbivory for a tropical‐temperate congener
pair. Ecological Monographs. 2020;90(1). doi:10.1002/ecm.1397
apa: Baskett, C., Schroeder, L., Weber, M. G., & Schemske, D. W. (2020). Multiple
metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate
congener pair. Ecological Monographs. Wiley. https://doi.org/10.1002/ecm.1397
chicago: Baskett, Carina, Lucy Schroeder, Marjorie G. Weber, and Douglas W. Schemske.
“Multiple Metrics of Latitudinal Patterns in Insect Pollination and Herbivory
for a Tropical‐temperate Congener Pair.” Ecological Monographs. Wiley,
2020. https://doi.org/10.1002/ecm.1397.
ieee: C. Baskett, L. Schroeder, M. G. Weber, and D. W. Schemske, “Multiple metrics
of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate
congener pair,” Ecological Monographs, vol. 90, no. 1. Wiley, 2020.
ista: Baskett C, Schroeder L, Weber MG, Schemske DW. 2020. Multiple metrics of latitudinal
patterns in insect pollination and herbivory for a tropical‐temperate congener
pair. Ecological Monographs. 90(1), e01397.
mla: Baskett, Carina, et al. “Multiple Metrics of Latitudinal Patterns in Insect
Pollination and Herbivory for a Tropical‐temperate Congener Pair.” Ecological
Monographs, vol. 90, no. 1, e01397, Wiley, 2020, doi:10.1002/ecm.1397.
short: C. Baskett, L. Schroeder, M.G. Weber, D.W. Schemske, Ecological Monographs
90 (2020).
date_created: 2020-01-07T12:47:07Z
date_published: 2020-02-01T00:00:00Z
date_updated: 2025-04-14T07:44:07Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1002/ecm.1397
ec_funded: 1
external_id:
isi:
- '000508511600001'
file:
- access_level: open_access
checksum: ab8130c6e68101f5a091d05324c36f08
content_type: application/pdf
creator: dernst
date_created: 2020-02-10T08:18:14Z
date_updated: 2020-07-14T12:47:54Z
file_id: '7469'
file_name: 2020_EcologMono_Baskett.pdf
file_size: 537941
relation: main_file
file_date_updated: 2020-07-14T12:47:54Z
has_accepted_license: '1'
intvolume: ' 90'
isi: 1
issue: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Ecological Monographs
publication_identifier:
eissn:
- 1557-7015
issn:
- 0012-9615
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multiple metrics of latitudinal patterns in insect pollination and herbivory
for a tropical‐temperate congener pair
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
volume: 90
year: '2020'
...
---
_id: '7253'
abstract:
- lang: eng
text: The cyclin-dependent kinase inhibitor p57KIP2 is encoded by the imprinted
Cdkn1c locus, exhibits maternal expression, and is essential for cerebral cortex
development. How Cdkn1c regulates corticogenesis is however not clear. To this
end we employ Mosaic Analysis with Double Markers (MADM) technology to genetically
dissect Cdkn1c gene function in corticogenesis at single cell resolution. We find
that the previously described growth-inhibitory Cdkn1c function is a non-cell-autonomous
one, acting on the whole organism. In contrast we reveal a growth-promoting cell-autonomous
Cdkn1c function which at the mechanistic level mediates radial glial progenitor
cell and nascent projection neuron survival. Strikingly, the growth-promoting
function of Cdkn1c is highly dosage sensitive but not subject to genomic imprinting.
Collectively, our results suggest that the Cdkn1c locus regulates cortical development
through distinct cell-autonomous and non-cell-autonomous mechanisms. More generally,
our study highlights the importance to probe the relative contributions of cell
intrinsic gene function and tissue-wide mechanisms to the overall phenotype.
acknowledged_ssus:
- _id: PreCl
article_number: '195'
article_processing_charge: No
article_type: original
author:
- first_name: Susanne
full_name: Laukoter, Susanne
id: 2D6B7A9A-F248-11E8-B48F-1D18A9856A87
last_name: Laukoter
orcid: 0000-0002-7903-3010
- first_name: Robert J
full_name: Beattie, Robert J
id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
last_name: Beattie
orcid: 0000-0002-8483-8753
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
orcid: 0000-0002-7462-0048
- first_name: Nicole
full_name: Amberg, Nicole
id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
last_name: Amberg
orcid: 0000-0002-3183-8207
- first_name: Keiichi I.
full_name: Nakayama, Keiichi I.
last_name: Nakayama
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Laukoter S, Beattie RJ, Pauler F, Amberg N, Nakayama KI, Hippenmeyer S. Imprinted
Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex
development. Nature Communications. 2020;11. doi:10.1038/s41467-019-14077-2
apa: Laukoter, S., Beattie, R. J., Pauler, F., Amberg, N., Nakayama, K. I., &
Hippenmeyer, S. (2020). Imprinted Cdkn1c genomic locus cell-autonomously promotes
cell survival in cerebral cortex development. Nature Communications. Springer
Nature. https://doi.org/10.1038/s41467-019-14077-2
chicago: Laukoter, Susanne, Robert J Beattie, Florian Pauler, Nicole Amberg, Keiichi
I. Nakayama, and Simon Hippenmeyer. “Imprinted Cdkn1c Genomic Locus Cell-Autonomously
Promotes Cell Survival in Cerebral Cortex Development.” Nature Communications.
Springer Nature, 2020. https://doi.org/10.1038/s41467-019-14077-2.
ieee: S. Laukoter, R. J. Beattie, F. Pauler, N. Amberg, K. I. Nakayama, and S. Hippenmeyer,
“Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral
cortex development,” Nature Communications, vol. 11. Springer Nature, 2020.
ista: Laukoter S, Beattie RJ, Pauler F, Amberg N, Nakayama KI, Hippenmeyer S. 2020.
Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral
cortex development. Nature Communications. 11, 195.
mla: Laukoter, Susanne, et al. “Imprinted Cdkn1c Genomic Locus Cell-Autonomously
Promotes Cell Survival in Cerebral Cortex Development.” Nature Communications,
vol. 11, 195, Springer Nature, 2020, doi:10.1038/s41467-019-14077-2.
short: S. Laukoter, R.J. Beattie, F. Pauler, N. Amberg, K.I. Nakayama, S. Hippenmeyer,
Nature Communications 11 (2020).
corr_author: '1'
date_created: 2020-01-11T10:42:48Z
date_published: 2020-01-10T00:00:00Z
date_updated: 2025-06-12T07:30:49Z
day: '10'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1038/s41467-019-14077-2
ec_funded: 1
external_id:
isi:
- '000551459000005'
pmid:
- '31924768'
file:
- access_level: open_access
checksum: ebf1ed522f4e0be8d94c939c1806a709
content_type: application/pdf
creator: dernst
date_created: 2020-01-13T07:42:31Z
date_updated: 2020-07-14T12:47:54Z
file_id: '7261'
file_name: 2020_NatureComm_Laukoter.pdf
file_size: 8063333
relation: main_file
file_date_updated: 2020-07-14T12:47:54Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 268F8446-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: T01031
name: Role of Eed in neural stem cell lineage progression
- _id: 264E56E2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02416
name: Molecular Mechanisms Regulating Gliogenesis in the Neocortex
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
- _id: 25D92700-B435-11E9-9278-68D0E5697425
grant_number: LS13-002
name: Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/new-function-for-potential-tumour-suppressor-in-brain-development/
scopus_import: '1'
status: public
title: Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in
cerebral cortex development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2020'
...
---
_id: '7262'
abstract:
- lang: eng
text: Advances in shape-morphing materials, such as hydrogels, shape-memory polymers
and light-responsive polymers have enabled prescribing self-directed deformations
of initially flat geometries. However, most proposed solutions evolve towards
a target geometry without considering time-dependent actuation paths. To achieve
more complex geometries and avoid self-collisions, it is critical to encode a
spatial and temporal shape evolution within the initially flat shell. Recent realizations
of time-dependent morphing are limited to the actuation of few, discrete hinges
and cannot form doubly curved surfaces. Here, we demonstrate a method for encoding
temporal shape evolution in architected shells that assume complex shapes and
doubly curved geometries. The shells are non-periodic tessellations of pre-stressed
contractile unit cells that soften in water at rates prescribed locally by mesostructure
geometry. The ensuing midplane contraction is coupled to the formation of encoded
curvatures. We propose an inverse design tool based on a data-driven model for
unit cells’ temporal responses.
article_number: '237'
article_processing_charge: No
article_type: original
author:
- first_name: Ruslan
full_name: Guseinov, Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
- first_name: Connor
full_name: McMahan, Connor
last_name: McMahan
- first_name: Jesus
full_name: Perez Rodriguez, Jesus
id: 2DC83906-F248-11E8-B48F-1D18A9856A87
last_name: Perez Rodriguez
- first_name: Chiara
full_name: Daraio, Chiara
last_name: Daraio
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
citation:
ama: Guseinov R, McMahan C, Perez Rodriguez J, Daraio C, Bickel B. Programming temporal
morphing of self-actuated shells. Nature Communications. 2020;11. doi:10.1038/s41467-019-14015-2
apa: Guseinov, R., McMahan, C., Perez Rodriguez, J., Daraio, C., & Bickel, B.
(2020). Programming temporal morphing of self-actuated shells. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-019-14015-2
chicago: Guseinov, Ruslan, Connor McMahan, Jesus Perez Rodriguez, Chiara Daraio,
and Bernd Bickel. “Programming Temporal Morphing of Self-Actuated Shells.” Nature
Communications. Springer Nature, 2020. https://doi.org/10.1038/s41467-019-14015-2.
ieee: R. Guseinov, C. McMahan, J. Perez Rodriguez, C. Daraio, and B. Bickel, “Programming
temporal morphing of self-actuated shells,” Nature Communications, vol.
11. Springer Nature, 2020.
ista: Guseinov R, McMahan C, Perez Rodriguez J, Daraio C, Bickel B. 2020. Programming
temporal morphing of self-actuated shells. Nature Communications. 11, 237.
mla: Guseinov, Ruslan, et al. “Programming Temporal Morphing of Self-Actuated Shells.”
Nature Communications, vol. 11, 237, Springer Nature, 2020, doi:10.1038/s41467-019-14015-2.
short: R. Guseinov, C. McMahan, J. Perez Rodriguez, C. Daraio, B. Bickel, Nature
Communications 11 (2020).
corr_author: '1'
date_created: 2020-01-13T16:54:26Z
date_published: 2020-01-13T00:00:00Z
date_updated: 2026-04-08T07:25:22Z
day: '13'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.1038/s41467-019-14015-2
ec_funded: 1
external_id:
isi:
- '000511916800015'
pmid:
- '31932589'
file:
- access_level: open_access
checksum: 7db23fef2f4cda712f17f1004116ddff
content_type: application/pdf
creator: rguseino
date_created: 2020-01-15T14:35:34Z
date_updated: 2020-07-14T12:47:55Z
file_id: '7336'
file_name: 2020_NatureComm_Guseinov.pdf
file_size: 1315270
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
keyword:
- Design
- Synthesis and processing
- Mechanical engineering
- Polymers
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/geometry-meets-time/
record:
- id: '7154'
relation: research_data
status: public
- id: '8366'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Programming temporal morphing of self-actuated shells
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2020'
...
---
_id: '7272'
abstract:
- lang: eng
text: "Many systems rely on optimistic concurrent search trees for multi-core scalability.
In principle, optimistic trees have a simple performance story: searches are read-only
and so run in parallel, with writes to shared memory occurring only when modifying
the data structure. However, this paper shows that in practice, obtaining the
full performance benefits of optimistic search trees is not so simple.\r\n\r\nWe
focus on optimistic binary search trees (BSTs) and perform a detailed performance
analysis of 10 state-of-the-art BSTs on large scale x86-64 hardware, using both
microbenchmarks and an in-memory database system. We find and explain significant
unexpected performance differences between BSTs with similar tree structure and
search implementations, which we trace to subtle performance-degrading interactions
of BSTs with systems software and hardware subsystems. We further derive a prescriptive
approach to avoid this performance degradation, as well as algorithmic insights
on optimistic BST design. Our work underlines the gap between the theory and practice
of multi-core performance, and calls for further research to help bridge this
gap."
article_processing_charge: No
author:
- first_name: Maya
full_name: Arbel-Raviv, Maya
last_name: Arbel-Raviv
- first_name: Trevor A
full_name: Brown, Trevor A
id: 3569F0A0-F248-11E8-B48F-1D18A9856A87
last_name: Brown
- first_name: Adam
full_name: Morrison, Adam
last_name: Morrison
citation:
ama: 'Arbel-Raviv M, Brown TA, Morrison A. Getting to the root of concurrent binary
search tree performance. In: Proceedings of the 2018 USENIX Annual Technical
Conference. USENIX Association; 2020:295-306.'
apa: 'Arbel-Raviv, M., Brown, T. A., & Morrison, A. (2020). Getting to the root
of concurrent binary search tree performance. In Proceedings of the 2018 USENIX
Annual Technical Conference (pp. 295–306). Boston, MA, United States: USENIX
Association.'
chicago: Arbel-Raviv, Maya, Trevor A Brown, and Adam Morrison. “Getting to the Root
of Concurrent Binary Search Tree Performance.” In Proceedings of the 2018 USENIX
Annual Technical Conference, 295–306. USENIX Association, 2020.
ieee: M. Arbel-Raviv, T. A. Brown, and A. Morrison, “Getting to the root of concurrent
binary search tree performance,” in Proceedings of the 2018 USENIX Annual Technical
Conference, Boston, MA, United States, 2020, pp. 295–306.
ista: 'Arbel-Raviv M, Brown TA, Morrison A. 2020. Getting to the root of concurrent
binary search tree performance. Proceedings of the 2018 USENIX Annual Technical
Conference. USENIX: Annual Technical Conference, 295–306.'
mla: Arbel-Raviv, Maya, et al. “Getting to the Root of Concurrent Binary Search
Tree Performance.” Proceedings of the 2018 USENIX Annual Technical Conference,
USENIX Association, 2020, pp. 295–306.
short: M. Arbel-Raviv, T.A. Brown, A. Morrison, in:, Proceedings of the 2018 USENIX
Annual Technical Conference, USENIX Association, 2020, pp. 295–306.
conference:
end_date: 2018-07-13
location: Boston, MA, United States
name: 'USENIX: Annual Technical Conference'
start_date: 2018-07-11
date_created: 2020-01-14T07:27:08Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2025-04-15T07:40:57Z
day: '01'
ddc:
- '000'
department:
- _id: DaAl
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.usenix.org/system/files/conference/atc18/atc18-arbel-raviv.pdf
month: '01'
oa: 1
oa_version: Published Version
page: 295-306
project:
- _id: 26450934-B435-11E9-9278-68D0E5697425
name: NSERC Postdoctoral fellowship
publication: Proceedings of the 2018 USENIX Annual Technical Conference
publication_identifier:
isbn:
- '9781939133021'
publication_status: published
publisher: USENIX Association
quality_controlled: '1'
scopus_import: '1'
status: public
title: Getting to the root of concurrent binary search tree performance
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7339'
abstract:
- lang: eng
text: Cytoskeletal filaments such as microtubules (MTs) and filamentous actin (F-actin)
dynamically support cell structure and functions. In central presynaptic terminals,
F-actin is expressed along the release edge and reportedly plays diverse functional
roles, but whether axonal MTs extend deep into terminals and play any physiological
role remains controversial. At the calyx of Held in rats of either sex, confocal
and high-resolution microscopy revealed that MTs enter deep into presynaptic terminal
swellings and partially colocalize with a subset of synaptic vesicles (SVs). Electrophysiological
analysis demonstrated that depolymerization of MTs specifically prolonged the
slow-recovery time component of EPSCs from short-term depression induced by a
train of high-frequency stimulation, whereas depolymerization of F-actin specifically
prolonged the fast-recovery component. In simultaneous presynaptic and postsynaptic
action potential recordings, depolymerization of MTs or F-actin significantly
impaired the fidelity of high-frequency neurotransmission. We conclude that MTs
and F-actin differentially contribute to slow and fast SV replenishment, thereby
maintaining high-frequency neurotransmission.
article_processing_charge: No
article_type: original
author:
- first_name: Lashmi
full_name: Piriya Ananda Babu, Lashmi
last_name: Piriya Ananda Babu
- first_name: Han Ying
full_name: Wang, Han Ying
last_name: Wang
- first_name: Kohgaku
full_name: Eguchi, Kohgaku
id: 2B7846DC-F248-11E8-B48F-1D18A9856A87
last_name: Eguchi
orcid: 0000-0002-6170-2546
- first_name: Laurent
full_name: Guillaud, Laurent
last_name: Guillaud
- first_name: Tomoyuki
full_name: Takahashi, Tomoyuki
last_name: Takahashi
citation:
ama: Piriya Ananda Babu L, Wang HY, Eguchi K, Guillaud L, Takahashi T. Microtubule
and actin differentially regulate synaptic vesicle cycling to maintain high-frequency
neurotransmission. Journal of neuroscience. 2020;40(1):131-142. doi:10.1523/JNEUROSCI.1571-19.2019
apa: Piriya Ananda Babu, L., Wang, H. Y., Eguchi, K., Guillaud, L., & Takahashi,
T. (2020). Microtubule and actin differentially regulate synaptic vesicle cycling
to maintain high-frequency neurotransmission. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.1571-19.2019
chicago: Piriya Ananda Babu, Lashmi, Han Ying Wang, Kohgaku Eguchi, Laurent Guillaud,
and Tomoyuki Takahashi. “Microtubule and Actin Differentially Regulate Synaptic
Vesicle Cycling to Maintain High-Frequency Neurotransmission.” Journal of Neuroscience.
Society for Neuroscience, 2020. https://doi.org/10.1523/JNEUROSCI.1571-19.2019.
ieee: L. Piriya Ananda Babu, H. Y. Wang, K. Eguchi, L. Guillaud, and T. Takahashi,
“Microtubule and actin differentially regulate synaptic vesicle cycling to maintain
high-frequency neurotransmission,” Journal of neuroscience, vol. 40, no.
1. Society for Neuroscience, pp. 131–142, 2020.
ista: Piriya Ananda Babu L, Wang HY, Eguchi K, Guillaud L, Takahashi T. 2020. Microtubule
and actin differentially regulate synaptic vesicle cycling to maintain high-frequency
neurotransmission. Journal of neuroscience. 40(1), 131–142.
mla: Piriya Ananda Babu, Lashmi, et al. “Microtubule and Actin Differentially Regulate
Synaptic Vesicle Cycling to Maintain High-Frequency Neurotransmission.” Journal
of Neuroscience, vol. 40, no. 1, Society for Neuroscience, 2020, pp. 131–42,
doi:10.1523/JNEUROSCI.1571-19.2019.
short: L. Piriya Ananda Babu, H.Y. Wang, K. Eguchi, L. Guillaud, T. Takahashi, Journal
of Neuroscience 40 (2020) 131–142.
date_created: 2020-01-19T23:00:38Z
date_published: 2020-01-02T00:00:00Z
date_updated: 2026-04-16T08:27:29Z
day: '02'
ddc:
- '570'
department:
- _id: RySh
doi: 10.1523/JNEUROSCI.1571-19.2019
external_id:
isi:
- '000505167600013'
pmid:
- '31767677'
file:
- access_level: open_access
checksum: 92f5e8a47f454fc131fb94cd7f106e60
content_type: application/pdf
creator: dernst
date_created: 2020-01-20T14:44:10Z
date_updated: 2020-07-14T12:47:56Z
file_id: '7345'
file_name: 2020_JourNeuroscience_Piriya.pdf
file_size: 4460781
relation: main_file
file_date_updated: 2020-07-14T12:47:56Z
has_accepted_license: '1'
intvolume: ' 40'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 131-142
pmid: 1
publication: Journal of neuroscience
publication_identifier:
eissn:
- 1529-2401
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
quality_controlled: '1'
scopus_import: '1'
status: public
title: Microtubule and actin differentially regulate synaptic vesicle cycling to maintain
high-frequency neurotransmission
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 40
year: '2020'
...