---
_id: '1167'
abstract:
- lang: eng
  text: Evolutionary pathways describe trajectories of biological evolution in the
    space of different variants of organisms (genotypes). The probability of existence
    and the number of evolutionary pathways that lead from a given genotype to a better-adapted
    genotype are important measures of accessibility of local fitness optima and the
    reproducibility of evolution. Both quantities have been studied in simple mathematical
    models where genotypes are represented as binary sequences of two types of basic
    units, and the network of permitted mutations between the genotypes is a hypercube
    graph. However, it is unclear how these results translate to the biologically
    relevant case in which genotypes are represented by sequences of more than two
    units, for example four nucleotides (DNA) or 20 amino acids (proteins), and the
    mutational graph is not the hypercube. Here we investigate accessibility of the
    best-adapted genotype in the general case of K &gt; 2 units. Using computer generated
    and experimental fitness landscapes we show that accessibility of the global fitness
    maximum increases with K and can be much higher than for binary sequences. The
    increase in accessibility comes from the increase in the number of indirect trajectories
    exploited by evolution for higher K. As one of the consequences, the fraction
    of genotypes that are accessible increases by three orders of magnitude when the
    number of units K increases from 2 to 16 for landscapes of size N ∼ 106genotypes.
    This suggests that evolution can follow many different trajectories on such landscapes
    and the reconstruction of evolutionary pathways from experimental data might be
    an extremely difficult task.
acknowledgement: MZ acknowledges the Polish National Science Centre grant no. DEC-2012/07/N/NZ2/00107.
  BW was supported by the Scottish Government/Royal Society of Edinburgh Personal
  Research Fellowship. We thank Marjon de Vos and Oliver Martin for critically reading
  the manuscript.
article_number: e1005218
article_processing_charge: No
author:
- first_name: Marcin P
  full_name: Zagórski, Marcin P
  id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
  last_name: Zagórski
  orcid: 0000-0001-7896-7762
- first_name: Zdzisław
  full_name: Burda, Zdzisław
  last_name: Burda
- first_name: Bartłomiej
  full_name: Wacław, Bartłomiej
  last_name: Wacław
citation:
  ama: Zagórski MP, Burda Z, Wacław B. Beyond the hypercube evolutionary accessibility
    of fitness landscapes with realistic mutational networks. <i>PLoS Computational
    Biology</i>. 2016;12(12). doi:<a href="https://doi.org/10.1371/journal.pcbi.1005218">10.1371/journal.pcbi.1005218</a>
  apa: Zagórski, M. P., Burda, Z., &#38; Wacław, B. (2016). Beyond the hypercube evolutionary
    accessibility of fitness landscapes with realistic mutational networks. <i>PLoS
    Computational Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pcbi.1005218">https://doi.org/10.1371/journal.pcbi.1005218</a>
  chicago: Zagórski, Marcin P, Zdzisław Burda, and Bartłomiej Wacław. “Beyond the
    Hypercube Evolutionary Accessibility of Fitness Landscapes with Realistic Mutational
    Networks.” <i>PLoS Computational Biology</i>. Public Library of Science, 2016.
    <a href="https://doi.org/10.1371/journal.pcbi.1005218">https://doi.org/10.1371/journal.pcbi.1005218</a>.
  ieee: M. P. Zagórski, Z. Burda, and B. Wacław, “Beyond the hypercube evolutionary
    accessibility of fitness landscapes with realistic mutational networks,” <i>PLoS
    Computational Biology</i>, vol. 12, no. 12. Public Library of Science, 2016.
  ista: Zagórski MP, Burda Z, Wacław B. 2016. Beyond the hypercube evolutionary accessibility
    of fitness landscapes with realistic mutational networks. PLoS Computational Biology.
    12(12), e1005218.
  mla: Zagórski, Marcin P., et al. “Beyond the Hypercube Evolutionary Accessibility
    of Fitness Landscapes with Realistic Mutational Networks.” <i>PLoS Computational
    Biology</i>, vol. 12, no. 12, e1005218, Public Library of Science, 2016, doi:<a
    href="https://doi.org/10.1371/journal.pcbi.1005218">10.1371/journal.pcbi.1005218</a>.
  short: M.P. Zagórski, Z. Burda, B. Wacław, PLoS Computational Biology 12 (2016).
date_created: 2018-12-11T11:50:30Z
date_published: 2016-12-09T00:00:00Z
date_updated: 2025-09-22T09:53:16Z
day: '09'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1371/journal.pcbi.1005218
external_id:
  isi:
  - '000392126000015'
file:
- access_level: open_access
  checksum: 84f44ae92866c52ff1ca8a574558dca7
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:08Z
  date_updated: 2020-07-14T12:44:37Z
  file_id: '4926'
  file_name: IST-2017-740-v1+1_journal.pcbi.1005218.pdf
  file_size: 3822299
  relation: main_file
file_date_updated: 2020-07-14T12:44:37Z
fulldoi: https://doi.org/10.1371/journal.pcbi.1005218
has_accepted_license: '1'
intvolume: '        12'
isi: 1
issue: '12'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '12'
oa: 1
oa_version: Published Version
publication: PLoS Computational Biology
publication_status: published
publisher: Public Library of Science
publist_id: '6190'
pubrep_id: '740'
quality_controlled: '1'
related_material:
  record:
  - id: '9866'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Beyond the hypercube evolutionary accessibility of fitness landscapes with
  realistic mutational networks
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 12
year: '2016'
...
---
_id: '1172'
abstract:
- lang: eng
  text: A central issue in cell biology is the physico-chemical basis of organelle
    biogenesis in intracellular trafficking pathways, its most impressive manifestation
    being the biogenesis of Golgi cisternae. At a basic level, such morphologically
    and chemically distinct compartments should arise from an interplay between the
    molecular transport and chemical maturation. Here, we formulate analytically tractable,
    minimalist models, that incorporate this interplay between transport and chemical
    progression in physical space, and explore the conditions for de novo biogenesis
    of distinct cisternae. We propose new quantitative measures that can discriminate
    between the various models of transport in a qualitative manner-this includes
    measures of the dynamics in steady state and the dynamical response to perturbations
    of the kind amenable to live-cell imaging.
acknowledgement: H.S. thanks NCBS for hospitality. We thank Vivek Malhotra and Mukund
  Thattai for critical discussions and suggestions.
article_number: '38840'
article_processing_charge: No
author:
- first_name: Himani
  full_name: Sachdeva, Himani
  id: 42377A0A-F248-11E8-B48F-1D18A9856A87
  last_name: Sachdeva
- first_name: Mustansir
  full_name: Barma, Mustansir
  last_name: Barma
- first_name: Madan
  full_name: Rao, Madan
  last_name: Rao
citation:
  ama: Sachdeva H, Barma M, Rao M. Nonequilibrium description of de novo biogenesis
    and transport through Golgi-like cisternae. <i>Scientific Reports</i>. 2016;6.
    doi:<a href="https://doi.org/10.1038/srep38840">10.1038/srep38840</a>
  apa: Sachdeva, H., Barma, M., &#38; Rao, M. (2016). Nonequilibrium description of
    de novo biogenesis and transport through Golgi-like cisternae. <i>Scientific Reports</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/srep38840">https://doi.org/10.1038/srep38840</a>
  chicago: Sachdeva, Himani, Mustansir Barma, and Madan Rao. “Nonequilibrium Description
    of de Novo Biogenesis and Transport through Golgi-like Cisternae.” <i>Scientific
    Reports</i>. Nature Publishing Group, 2016. <a href="https://doi.org/10.1038/srep38840">https://doi.org/10.1038/srep38840</a>.
  ieee: H. Sachdeva, M. Barma, and M. Rao, “Nonequilibrium description of de novo
    biogenesis and transport through Golgi-like cisternae,” <i>Scientific Reports</i>,
    vol. 6. Nature Publishing Group, 2016.
  ista: Sachdeva H, Barma M, Rao M. 2016. Nonequilibrium description of de novo biogenesis
    and transport through Golgi-like cisternae. Scientific Reports. 6, 38840.
  mla: Sachdeva, Himani, et al. “Nonequilibrium Description of de Novo Biogenesis
    and Transport through Golgi-like Cisternae.” <i>Scientific Reports</i>, vol. 6,
    38840, Nature Publishing Group, 2016, doi:<a href="https://doi.org/10.1038/srep38840">10.1038/srep38840</a>.
  short: H. Sachdeva, M. Barma, M. Rao, Scientific Reports 6 (2016).
date_created: 2018-12-11T11:50:32Z
date_published: 2016-12-19T00:00:00Z
date_updated: 2025-09-22T09:49:53Z
day: '19'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1038/srep38840
external_id:
  isi:
  - '000389885900001'
file:
- access_level: open_access
  checksum: cb378732da885ea4959ec5b845fb6e52
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:56Z
  date_updated: 2020-07-14T12:44:37Z
  file_id: '4977'
  file_name: IST-2017-737-v1+1_srep38840.pdf
  file_size: 760967
  relation: main_file
file_date_updated: 2020-07-14T12:44:37Z
fulldoi: https://doi.org/10.1038/srep38840
has_accepted_license: '1'
intvolume: '         6'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Scientific Reports
publication_status: published
publisher: Nature Publishing Group
publist_id: '6183'
pubrep_id: '737'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nonequilibrium description of de novo biogenesis and transport through Golgi-like
  cisternae
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 6
year: '2016'
...
---
_id: '1177'
abstract:
- lang: eng
  text: Boldyreva, Palacio and Warinschi introduced a multiple forking game as an
    extension of general forking. The notion of (multiple) forking is a useful abstraction
    from the actual simulation of cryptographic scheme to the adversary in a security
    reduction, and is achieved through the intermediary of a so-called wrapper algorithm.
    Multiple forking has turned out to be a useful tool in the security argument of
    several cryptographic protocols. However, a reduction employing multiple forking
    incurs a significant degradation of (Formula presented.) , where (Formula presented.)
    denotes the upper bound on the underlying random oracle calls and (Formula presented.)
    , the number of forkings. In this work we take a closer look at the reasons for
    the degradation with a tighter security bound in mind. We nail down the exact
    set of conditions for success in the multiple forking game. A careful analysis
    of the cryptographic schemes and corresponding security reduction employing multiple
    forking leads to the formulation of ‘dependence’ and ‘independence’ conditions
    pertaining to the output of the wrapper in different rounds. Based on the (in)dependence
    conditions we propose a general framework of multiple forking and a General Multiple
    Forking Lemma. Leveraging (in)dependence to the full allows us to improve the
    degradation factor in the multiple forking game by a factor of (Formula presented.).
    By implication, the cost of a single forking involving two random oracles (augmented
    forking) matches that involving a single random oracle (elementary forking). Finally,
    we study the effect of these observations on the concrete security of existing
    schemes employing multiple forking. We conclude that by careful design of the
    protocol (and the wrapper in the security reduction) it is possible to harness
    our observations to the full extent.
acknowledgement: "We are grateful to the anonymous reviewers for their insightful
  comments. The\r\ndetailed reports helped us a lot to address the technical mistakes
  as well as to improve the overall presentation of the paper."
article_processing_charge: No
author:
- first_name: Chethan
  full_name: Kamath Hosdurg, Chethan
  id: 4BD3F30E-F248-11E8-B48F-1D18A9856A87
  last_name: Kamath Hosdurg
  orcid: 0009-0006-6812-7317
- first_name: Sanjit
  full_name: Chatterjee, Sanjit
  last_name: Chatterjee
citation:
  ama: 'Kamath Hosdurg C, Chatterjee S. A closer look at multiple-forking: Leveraging
    (in)dependence for a tighter bound. <i>Algorithmica</i>. 2016;74(4):1321-1362.
    doi:<a href="https://doi.org/10.1007/s00453-015-9997-6">10.1007/s00453-015-9997-6</a>'
  apa: 'Kamath Hosdurg, C., &#38; Chatterjee, S. (2016). A closer look at multiple-forking:
    Leveraging (in)dependence for a tighter bound. <i>Algorithmica</i>. Springer.
    <a href="https://doi.org/10.1007/s00453-015-9997-6">https://doi.org/10.1007/s00453-015-9997-6</a>'
  chicago: 'Kamath Hosdurg, Chethan, and Sanjit Chatterjee. “A Closer Look at Multiple-Forking:
    Leveraging (in)Dependence for a Tighter Bound.” <i>Algorithmica</i>. Springer,
    2016. <a href="https://doi.org/10.1007/s00453-015-9997-6">https://doi.org/10.1007/s00453-015-9997-6</a>.'
  ieee: 'C. Kamath Hosdurg and S. Chatterjee, “A closer look at multiple-forking:
    Leveraging (in)dependence for a tighter bound,” <i>Algorithmica</i>, vol. 74,
    no. 4. Springer, pp. 1321–1362, 2016.'
  ista: 'Kamath Hosdurg C, Chatterjee S. 2016. A closer look at multiple-forking:
    Leveraging (in)dependence for a tighter bound. Algorithmica. 74(4), 1321–1362.'
  mla: 'Kamath Hosdurg, Chethan, and Sanjit Chatterjee. “A Closer Look at Multiple-Forking:
    Leveraging (in)Dependence for a Tighter Bound.” <i>Algorithmica</i>, vol. 74,
    no. 4, Springer, 2016, pp. 1321–62, doi:<a href="https://doi.org/10.1007/s00453-015-9997-6">10.1007/s00453-015-9997-6</a>.'
  short: C. Kamath Hosdurg, S. Chatterjee, Algorithmica 74 (2016) 1321–1362.
cryptoeprintid: 1
das_tickbox: '1'
date_created: 2018-12-11T11:50:33Z
date_published: 2016-04-01T00:00:00Z
date_updated: 2026-06-22T14:07:33Z
day: '01'
department:
- _id: KrPi
doi: 10.1007/s00453-015-9997-6
external_id:
  cryptoeprintid:
  - 2013/651
  isi:
  - '000373640000005'
fulldoi: https://doi.org/10.1007/s00453-015-9997-6
intvolume: '        74'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://eprint.iacr.org/2013/651
month: '04'
oa: 1
oa_version: Submitted Version
page: 1321 - 1362
publication: Algorithmica
publication_status: published
publisher: Springer
publist_id: '6177'
quality_controlled: '1'
status: public
title: 'A closer look at multiple-forking: Leveraging (in)dependence for a tighter
  bound'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 74
year: '2016'
...
---
_id: '1179'
abstract:
- lang: eng
  text: "Computational notions of entropy have recently found many applications, including
    leakage-resilient cryptography, deterministic encryption or memory delegation.
    The two main types of results which make computational notions so useful are (1)
    Chain rules, which quantify by how much the computational entropy of a variable
    decreases if conditioned on some other variable (2) Transformations, which quantify
    to which extend one type of entropy implies another.\r\n\r\nSuch chain rules and
    transformations typically lose a significant amount in quality of the entropy,
    and are the reason why applying these results one gets rather weak quantitative
    security bounds. In this paper we for the first time prove lower bounds in this
    context, showing that existing results for transformations are, unfortunately,
    basically optimal for non-adaptive black-box reductions (and it’s hard to imagine
    how non black-box reductions or adaptivity could be useful here.)\r\n\r\nA variable
    X has k bits of HILL entropy of quality (ϵ,s)\r\nif there exists a variable Y
    with k bits min-entropy which cannot be distinguished from X with advantage ϵ\r\n\r\nby
    distinguishing circuits of size s. A weaker notion is Metric entropy, where we
    switch quantifiers, and only require that for every distinguisher of size s, such
    a Y exists.\r\n\r\nWe first describe our result concerning transformations. By
    definition, HILL implies Metric without any loss in quality. Metric entropy often
    comes up in applications, but must be transformed to HILL for meaningful security
    guarantees. The best known result states that if a variable X has k bits of Metric
    entropy of quality (ϵ,s)\r\n, then it has k bits of HILL with quality (2ϵ,s⋅ϵ2).
    We show that this loss of a factor Ω(ϵ−2)\r\n\r\nin circuit size is necessary.
    In fact, we show the stronger result that this loss is already necessary when
    transforming so called deterministic real valued Metric entropy to randomised
    boolean Metric (both these variants of Metric entropy are implied by HILL without
    loss in quality).\r\n\r\nThe chain rule for HILL entropy states that if X has
    k bits of HILL entropy of quality (ϵ,s)\r\n, then for any variable Z of length
    m, X conditioned on Z has k−m bits of HILL entropy with quality (ϵ,s⋅ϵ2/2m). We
    show that a loss of Ω(2m/ϵ) in circuit size necessary here. Note that this still
    leaves a gap of ϵ between the known bound and our lower bound."
acknowledgement: "K. Pietrzak—Supported by the European Research Council consolidator
  grant (682815-TOCNeT).\r\nM. Skórski—Supported by the National Science Center, Poland
  (2015/17/N/ST6/03564)."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Krzysztof Z
  full_name: Pietrzak, Krzysztof Z
  id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
  last_name: Pietrzak
  orcid: 0000-0002-9139-1654
- first_name: Skorski
  full_name: Maciej, Skorski
  last_name: Maciej
citation:
  ama: 'Pietrzak KZ, Maciej S. Pseudoentropy: Lower-bounds for chain rules and transformations.
    In: Vol 9985. Springer; 2016:183-203. doi:<a href="https://doi.org/10.1007/978-3-662-53641-4_8">10.1007/978-3-662-53641-4_8</a>'
  apa: 'Pietrzak, K. Z., &#38; Maciej, S. (2016). Pseudoentropy: Lower-bounds for
    chain rules and transformations (Vol. 9985, pp. 183–203). Presented at the TCC:
    Theory of Cryptography Conference, Beijing, China: Springer. <a href="https://doi.org/10.1007/978-3-662-53641-4_8">https://doi.org/10.1007/978-3-662-53641-4_8</a>'
  chicago: 'Pietrzak, Krzysztof Z, and Skorski Maciej. “Pseudoentropy: Lower-Bounds
    for Chain Rules and Transformations,” 9985:183–203. Springer, 2016. <a href="https://doi.org/10.1007/978-3-662-53641-4_8">https://doi.org/10.1007/978-3-662-53641-4_8</a>.'
  ieee: 'K. Z. Pietrzak and S. Maciej, “Pseudoentropy: Lower-bounds for chain rules
    and transformations,” presented at the TCC: Theory of Cryptography Conference,
    Beijing, China, 2016, vol. 9985, pp. 183–203.'
  ista: 'Pietrzak KZ, Maciej S. 2016. Pseudoentropy: Lower-bounds for chain rules
    and transformations. TCC: Theory of Cryptography Conference, LNCS, vol. 9985,
    183–203.'
  mla: 'Pietrzak, Krzysztof Z., and Skorski Maciej. <i>Pseudoentropy: Lower-Bounds
    for Chain Rules and Transformations</i>. Vol. 9985, Springer, 2016, pp. 183–203,
    doi:<a href="https://doi.org/10.1007/978-3-662-53641-4_8">10.1007/978-3-662-53641-4_8</a>.'
  short: K.Z. Pietrzak, S. Maciej, in:, Springer, 2016, pp. 183–203.
conference:
  end_date: 2016-11-03
  location: Beijing, China
  name: 'TCC: Theory of Cryptography Conference'
  start_date: 2016-10-31
date_created: 2018-12-11T11:50:34Z
date_published: 2016-10-22T00:00:00Z
date_updated: 2025-09-22T09:48:49Z
day: '22'
department:
- _id: KrPi
doi: 10.1007/978-3-662-53641-4_8
ec_funded: 1
external_id:
  isi:
  - '000390176000008'
fulldoi: https://doi.org/10.1007/978-3-662-53641-4_8
intvolume: '      9985'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://eprint.iacr.org/2016/159
month: '10'
oa: 1
oa_version: Preprint
page: 183 - 203
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '682815'
  name: Teaching Old Crypto New Tricks
publication_status: published
publisher: Springer
publist_id: '6175'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Pseudoentropy: Lower-bounds for chain rules and transformations'
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 9985
year: '2016'
...
---
_id: '1182'
abstract:
- lang: eng
  text: 'Balanced knockout tournaments are ubiquitous in sports competitions and are
    also used in decisionmaking and elections. The traditional computational question,
    that asks to compute a draw (optimal draw) that maximizes the winning probability
    for a distinguished player, has received a lot of attention. Previous works consider
    the problem where the pairwise winning probabilities are known precisely, while
    we study how robust is the winning probability with respect to small errors in
    the pairwise winning probabilities. First, we present several illuminating examples
    to establish: (a) there exist deterministic tournaments (where the pairwise winning
    probabilities are 0 or 1) where one optimal draw is much more robust than the
    other; and (b) in general, there exist tournaments with slightly suboptimal draws
    that are more robust than all the optimal draws. The above examples motivate the
    study of the computational problem of robust draws that guarantee a specified
    winning probability. Second, we present a polynomial-time algorithm for approximating
    the robustness of a draw for sufficiently small errors in pairwise winning probabilities,
    and obtain that the stated computational problem is NP-complete. We also show
    that two natural cases of deterministic tournaments where the optimal draw could
    be computed in polynomial time also admit polynomial-time algorithms to compute
    robust optimal draws.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Rasmus
  full_name: Ibsen-Jensen, Rasmus
  id: 3B699956-F248-11E8-B48F-1D18A9856A87
  last_name: Ibsen-Jensen
  orcid: 0000-0003-4783-0389
- first_name: Josef
  full_name: Tkadlec, Josef
  id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
  last_name: Tkadlec
  orcid: 0000-0002-1097-9684
citation:
  ama: 'Chatterjee K, Ibsen-Jensen R, Tkadlec J. Robust draws in balanced knockout
    tournaments. In: Vol 2016-January. AAAI Press; 2016:172-179.'
  apa: 'Chatterjee, K., Ibsen-Jensen, R., &#38; Tkadlec, J. (2016). Robust draws in
    balanced knockout tournaments (Vol. 2016–January, pp. 172–179). Presented at the
    IJCAI: International Joint Conference on Artificial Intelligence, New York, NY,
    USA: AAAI Press.'
  chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, and Josef Tkadlec. “Robust
    Draws in Balanced Knockout Tournaments,” 2016–January:172–79. AAAI Press, 2016.
  ieee: 'K. Chatterjee, R. Ibsen-Jensen, and J. Tkadlec, “Robust draws in balanced
    knockout tournaments,” presented at the IJCAI: International Joint Conference
    on Artificial Intelligence, New York, NY, USA, 2016, vol. 2016–January, pp. 172–179.'
  ista: 'Chatterjee K, Ibsen-Jensen R, Tkadlec J. 2016. Robust draws in balanced knockout
    tournaments. IJCAI: International Joint Conference on Artificial Intelligence
    vol. 2016–January, 172–179.'
  mla: Chatterjee, Krishnendu, et al. <i>Robust Draws in Balanced Knockout Tournaments</i>.
    Vol. 2016–January, AAAI Press, 2016, pp. 172–79.
  short: K. Chatterjee, R. Ibsen-Jensen, J. Tkadlec, in:, AAAI Press, 2016, pp. 172–179.
conference:
  end_date: 2016-07-15
  location: New York, NY, USA
  name: 'IJCAI: International Joint Conference on Artificial Intelligence'
  start_date: 2016-07-09
corr_author: '1'
date_created: 2018-12-11T11:50:35Z
date_published: 2016-01-01T00:00:00Z
date_updated: 2025-04-22T13:42:22Z
day: '01'
department:
- _id: KrCh
ec_funded: 1
external_id:
  arxiv:
  - '1604.05090'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1604.05090
month: '01'
oa: 1
oa_version: Preprint
page: 172 - 179
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
  grant_number: ICT15-003
  name: Efficient Algorithms for Computer Aided Verification
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '267989'
  name: Quantitative Reactive Modeling
publication_status: published
publisher: AAAI Press
publist_id: '6171'
quality_controlled: '1'
related_material:
  link:
  - relation: table_of_contents
    url: https://www.ijcai.org/proceedings/2016
scopus_import: '1'
status: public
title: Robust draws in balanced knockout tournaments
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2016-January
year: '2016'
...
---
_id: '11834'
abstract:
- lang: eng
  text: "We present a deterministic incremental algorithm for exactly maintaining
    the size of a minimum cut with ~O(1) amortized time per edge insertion and O(1)
    query time. This result partially answers an open question posed by Thorup [Combinatorica
    2007]. It also stays in sharp contrast to a polynomial conditional lower-bound
    for the fully-dynamic weighted minimum cut problem. Our algorithm is obtained
    by combining a recent sparsification technique of Kawarabayashi and Thorup [STOC
    2015] and an exact incremental algorithm of Henzinger [J. of Algorithm 1997].\r\n\r\nWe
    also study space-efficient incremental algorithms for the minimum cut problem.
    Concretely, we show that there exists an O(n log n/epsilon^2) space Monte-Carlo
    algorithm that can process a stream of edge insertions starting from an empty
    graph, and with high probability, the algorithm maintains a (1+epsilon)-approximation
    to the minimum cut. The algorithm has ~O(1) amortized update-time and constant
    query-time."
alternative_title:
- LIPIcs
article_number: '46'
article_processing_charge: No
arxiv: 1
author:
- first_name: Gramoz
  full_name: Goranci, Gramoz
  last_name: Goranci
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Mikkel
  full_name: Thorup, Mikkel
  last_name: Thorup
citation:
  ama: 'Goranci G, Henzinger M, Thorup M. Incremental exact min-cut in poly-logarithmic
    amortized update time. In: <i>24th Annual European Symposium on Algorithms</i>.
    Vol 57. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2016. doi:<a href="https://doi.org/10.4230/LIPICS.ESA.2016.46">10.4230/LIPICS.ESA.2016.46</a>'
  apa: 'Goranci, G., Henzinger, M., &#38; Thorup, M. (2016). Incremental exact min-cut
    in poly-logarithmic amortized update time. In <i>24th Annual European Symposium
    on Algorithms</i> (Vol. 57). Aarhus, Denmark: Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik. <a href="https://doi.org/10.4230/LIPICS.ESA.2016.46">https://doi.org/10.4230/LIPICS.ESA.2016.46</a>'
  chicago: Goranci, Gramoz, Monika Henzinger, and Mikkel Thorup. “Incremental Exact
    Min-Cut in Poly-Logarithmic Amortized Update Time.” In <i>24th Annual European
    Symposium on Algorithms</i>, Vol. 57. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2016. <a href="https://doi.org/10.4230/LIPICS.ESA.2016.46">https://doi.org/10.4230/LIPICS.ESA.2016.46</a>.
  ieee: G. Goranci, M. Henzinger, and M. Thorup, “Incremental exact min-cut in poly-logarithmic
    amortized update time,” in <i>24th Annual European Symposium on Algorithms</i>,
    Aarhus, Denmark, 2016, vol. 57.
  ista: 'Goranci G, Henzinger M, Thorup M. 2016. Incremental exact min-cut in poly-logarithmic
    amortized update time. 24th Annual European Symposium on Algorithms. ESA: Annual
    European Symposium on Algorithms, LIPIcs, vol. 57, 46.'
  mla: Goranci, Gramoz, et al. “Incremental Exact Min-Cut in Poly-Logarithmic Amortized
    Update Time.” <i>24th Annual European Symposium on Algorithms</i>, vol. 57, 46,
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016, doi:<a href="https://doi.org/10.4230/LIPICS.ESA.2016.46">10.4230/LIPICS.ESA.2016.46</a>.
  short: G. Goranci, M. Henzinger, M. Thorup, in:, 24th Annual European Symposium
    on Algorithms, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016.
conference:
  end_date: 2016-08-24
  location: Aarhus, Denmark
  name: 'ESA: Annual European Symposium on Algorithms'
  start_date: 2016-08-22
date_created: 2022-08-12T10:58:32Z
date_published: 2016-08-18T00:00:00Z
date_updated: 2024-11-06T11:58:55Z
day: '18'
doi: 10.4230/LIPICS.ESA.2016.46
extern: '1'
external_id:
  arxiv:
  - '1611.06500'
fulldoi: https://doi.org/10.4230/LIPICS.ESA.2016.46
intvolume: '        57'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.4230/LIPIcs.ESA.2016.46
month: '08'
oa: 1
oa_version: Published Version
publication: 24th Annual European Symposium on Algorithms
publication_identifier:
  isbn:
  - 978-3-95977-015-6
  issn:
  - 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Incremental exact min-cut in poly-logarithmic amortized update time
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2016'
...
---
_id: '11835'
abstract:
- lang: eng
  text: "During the last 10 years it has become popular to study dynamic graph problems
    in a emergency planning or sensitivity setting: Instead of considering the general
    fully dynamic problem, we only have to process a single batch update of size d;
    after the update we have to answer queries.\r\n\r\nIn this paper, we consider
    the dynamic subgraph connectivity problem with sensitivity d: We are given a graph
    of which some vertices are activated and some are deactivated. After that we get
    a single update in which the states of up to $d$ vertices are changed. Then we
    get a sequence of connectivity queries in the subgraph of activated vertices.\r\n\r\nWe
    present the first fully dynamic algorithm for this problem which has an update
    and query time only slightly worse than the best decremental algorithm. In addition,
    we present the first incremental algorithm which is tight with respect to the
    best known conditional lower bound; moreover, the algorithm is simple and we believe
    it is implementable and efficient in practice."
alternative_title:
- LIPIcs
article_number: '48'
article_processing_charge: No
arxiv: 1
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Stefan
  full_name: Neumann, Stefan
  last_name: Neumann
citation:
  ama: 'Henzinger M, Neumann S. Incremental and fully dynamic subgraph connectivity
    for emergency planning. In: <i>24th Annual European Symposium on Algorithms</i>.
    Vol 57. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2016. doi:<a href="https://doi.org/10.4230/LIPICS.ESA.2016.48">10.4230/LIPICS.ESA.2016.48</a>'
  apa: 'Henzinger, M., &#38; Neumann, S. (2016). Incremental and fully dynamic subgraph
    connectivity for emergency planning. In <i>24th Annual European Symposium on Algorithms</i>
    (Vol. 57). Aarhus, Denmark: Schloss Dagstuhl - Leibniz-Zentrum für Informatik.
    <a href="https://doi.org/10.4230/LIPICS.ESA.2016.48">https://doi.org/10.4230/LIPICS.ESA.2016.48</a>'
  chicago: Henzinger, Monika, and Stefan Neumann. “Incremental and Fully Dynamic Subgraph
    Connectivity for Emergency Planning.” In <i>24th Annual European Symposium on
    Algorithms</i>, Vol. 57. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016.
    <a href="https://doi.org/10.4230/LIPICS.ESA.2016.48">https://doi.org/10.4230/LIPICS.ESA.2016.48</a>.
  ieee: M. Henzinger and S. Neumann, “Incremental and fully dynamic subgraph connectivity
    for emergency planning,” in <i>24th Annual European Symposium on Algorithms</i>,
    Aarhus, Denmark, 2016, vol. 57.
  ista: 'Henzinger M, Neumann S. 2016. Incremental and fully dynamic subgraph connectivity
    for emergency planning. 24th Annual European Symposium on Algorithms. ESA: Annual
    European Symposium on Algorithms, LIPIcs, vol. 57, 48.'
  mla: Henzinger, Monika, and Stefan Neumann. “Incremental and Fully Dynamic Subgraph
    Connectivity for Emergency Planning.” <i>24th Annual European Symposium on Algorithms</i>,
    vol. 57, 48, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016, doi:<a href="https://doi.org/10.4230/LIPICS.ESA.2016.48">10.4230/LIPICS.ESA.2016.48</a>.
  short: M. Henzinger, S. Neumann, in:, 24th Annual European Symposium on Algorithms,
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016.
conference:
  end_date: 2016-08-24
  location: Aarhus, Denmark
  name: 'ESA: Annual European Symposium on Algorithms'
  start_date: 2016-08-22
date_created: 2022-08-12T11:05:41Z
date_published: 2016-08-18T00:00:00Z
date_updated: 2024-11-06T11:59:06Z
day: '18'
doi: 10.4230/LIPICS.ESA.2016.48
extern: '1'
external_id:
  arxiv:
  - '1611.05248'
fulldoi: https://doi.org/10.4230/LIPICS.ESA.2016.48
intvolume: '        57'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.4230/LIPIcs.ESA.2016.48
month: '08'
oa: 1
oa_version: Published Version
publication: 24th Annual European Symposium on Algorithms
publication_identifier:
  isbn:
  - 978-3-95977-015-6
  issn:
  - 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Incremental and fully dynamic subgraph connectivity for emergency planning
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2016'
...
---
_id: '11836'
abstract:
- lang: eng
  text: "Given a graph where vertices are partitioned into k terminals and non-terminals,
    the goal is to compress the graph (i.e., reduce the number of non-terminals) using
    minor operations while preserving terminal distances approximately. The distortion
    of a compressed graph is the maximum multiplicative blow-up of distances between
    all pairs of terminals. We study the trade-off between the number of non-terminals
    and the distortion. This problem generalizes the Steiner Point Removal (SPR) problem,
    in which all non-terminals must be removed.\r\n\r\nWe introduce a novel black-box
    reduction to convert any lower bound on distortion for the SPR problem into a
    super-linear lower bound on the number of non-terminals, with the same distortion,
    for our problem. This allows us to show that there exist graphs such that every
    minor with distortion less than 2 / 2.5 / 3 must have Omega(k^2) / Omega(k^{5/4})
    / Omega(k^{6/5}) non-terminals, plus more trade-offs in between. The black-box
    reduction has an interesting consequence: if the tight lower bound on distortion
    for the SPR problem is super-constant, then allowing any O(k) non-terminals will
    not help improving the lower bound to a constant.\r\n\r\nWe also build on the
    existing results on spanners, distance oracles and connected 0-extensions to show
    a number of upper bounds for general graphs, planar graphs, graphs that exclude
    a fixed minor and bounded treewidth graphs. Among others, we show that any graph
    admits a minor with O(log k) distortion and O(k^2) non-terminals, and any planar
    graph admits a minor with\r\n1 + epsilon distortion and ~O((k/epsilon)^2) non-terminals."
alternative_title:
- LIPIcs
article_number: '131'
article_processing_charge: No
arxiv: 1
author:
- first_name: Yun Kuen
  full_name: Cheung, Yun Kuen
  last_name: Cheung
- first_name: Gramoz
  full_name: Goranci, Gramoz
  last_name: Goranci
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
citation:
  ama: 'Cheung YK, Goranci G, Henzinger M. Graph minors for preserving terminal distances
    approximately - lower and upper bounds. In: <i>43rd International Colloquium on
    Automata, Languages, and Programming</i>. Vol 55. Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik; 2016. doi:<a href="https://doi.org/10.4230/LIPICS.ICALP.2016.131">10.4230/LIPICS.ICALP.2016.131</a>'
  apa: 'Cheung, Y. K., Goranci, G., &#38; Henzinger, M. (2016). Graph minors for preserving
    terminal distances approximately - lower and upper bounds. In <i>43rd International
    Colloquium on Automata, Languages, and Programming</i> (Vol. 55). Rome, Italy:
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPICS.ICALP.2016.131">https://doi.org/10.4230/LIPICS.ICALP.2016.131</a>'
  chicago: Cheung, Yun Kuen, Gramoz Goranci, and Monika Henzinger. “Graph Minors for
    Preserving Terminal Distances Approximately - Lower and Upper Bounds.” In <i>43rd
    International Colloquium on Automata, Languages, and Programming</i>, Vol. 55.
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016. <a href="https://doi.org/10.4230/LIPICS.ICALP.2016.131">https://doi.org/10.4230/LIPICS.ICALP.2016.131</a>.
  ieee: Y. K. Cheung, G. Goranci, and M. Henzinger, “Graph minors for preserving terminal
    distances approximately - lower and upper bounds,” in <i>43rd International Colloquium
    on Automata, Languages, and Programming</i>, Rome, Italy, 2016, vol. 55.
  ista: 'Cheung YK, Goranci G, Henzinger M. 2016. Graph minors for preserving terminal
    distances approximately - lower and upper bounds. 43rd International Colloquium
    on Automata, Languages, and Programming. ICALP: International Colloquium on Automata,
    Languages, and Programming, LIPIcs, vol. 55, 131.'
  mla: Cheung, Yun Kuen, et al. “Graph Minors for Preserving Terminal Distances Approximately
    - Lower and Upper Bounds.” <i>43rd International Colloquium on Automata, Languages,
    and Programming</i>, vol. 55, 131, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2016, doi:<a href="https://doi.org/10.4230/LIPICS.ICALP.2016.131">10.4230/LIPICS.ICALP.2016.131</a>.
  short: Y.K. Cheung, G. Goranci, M. Henzinger, in:, 43rd International Colloquium
    on Automata, Languages, and Programming, Schloss Dagstuhl - Leibniz-Zentrum für
    Informatik, 2016.
conference:
  end_date: 2016-07-15
  location: Rome, Italy
  name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
  start_date: 2016-07-12
date_created: 2022-08-12T11:16:01Z
date_published: 2016-08-23T00:00:00Z
date_updated: 2024-11-06T11:58:15Z
day: '23'
doi: 10.4230/LIPICS.ICALP.2016.131
extern: '1'
external_id:
  arxiv:
  - '1604.08342'
fulldoi: https://doi.org/10.4230/LIPICS.ICALP.2016.131
intvolume: '        55'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.4230/LIPICS.ICALP.2016.131
month: '08'
oa: 1
oa_version: Published Version
publication: 43rd International Colloquium on Automata, Languages, and Programming
publication_identifier:
  isbn:
  - 978-3-95977-013-2
  issn:
  - 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Graph minors for preserving terminal distances approximately - lower and upper
  bounds
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '2016'
...
---
_id: '1184'
abstract:
- lang: eng
  text: Across multicellular organisms, the costs of reproduction and self-maintenance
    result in a life history trade-off between fecundity and longevity. Queens of
    perennial social Hymenoptera are both highly fertile and long-lived, and thus,
    this fundamental trade-off is lacking. Whether social insect males similarly evade
    the fecundity/longevity trade-off remains largely unstudied. Wingless males of
    the ant genus Cardiocondyla stay in their natal colonies throughout their relatively
    long lives and mate with multiple female sexuals. Here, we show that Cardiocondyla
    obscurior males that were allowed to mate with large numbers of female sexuals
    had a shortened life span compared to males that mated at a low frequency or virgin
    males. Although frequent mating negatively affects longevity, males clearly benefit
    from a “live fast, die young strategy” by inseminating as many female sexuals
    as possible at a cost to their own survival.
acknowledgement: 'German Science Foundation. Grant Number: SCHR 1135/2-1. We thank
  M. Adam for handling part of the setups and J. Zoellner for behavioral observations.'
article_processing_charge: No
author:
- first_name: Sina
  full_name: Metzler, Sina
  id: 48204546-F248-11E8-B48F-1D18A9856A87
  last_name: Metzler
  orcid: 0000-0002-9547-2494
- first_name: Jürgen
  full_name: Heinze, Jürgen
  last_name: Heinze
- first_name: Alexandra
  full_name: Schrempf, Alexandra
  last_name: Schrempf
citation:
  ama: Metzler S, Heinze J, Schrempf A. Mating and longevity in ant males. <i>Ecology
    and Evolution</i>. 2016;6(24):8903-8906. doi:<a href="https://doi.org/10.1002/ece3.2474">10.1002/ece3.2474</a>
  apa: Metzler, S., Heinze, J., &#38; Schrempf, A. (2016). Mating and longevity in
    ant males. <i>Ecology and Evolution</i>. Wiley-Blackwell. <a href="https://doi.org/10.1002/ece3.2474">https://doi.org/10.1002/ece3.2474</a>
  chicago: Metzler, Sina, Jürgen Heinze, and Alexandra Schrempf. “Mating and Longevity
    in Ant Males.” <i>Ecology and Evolution</i>. Wiley-Blackwell, 2016. <a href="https://doi.org/10.1002/ece3.2474">https://doi.org/10.1002/ece3.2474</a>.
  ieee: S. Metzler, J. Heinze, and A. Schrempf, “Mating and longevity in ant males,”
    <i>Ecology and Evolution</i>, vol. 6, no. 24. Wiley-Blackwell, pp. 8903–8906,
    2016.
  ista: Metzler S, Heinze J, Schrempf A. 2016. Mating and longevity in ant males.
    Ecology and Evolution. 6(24), 8903–8906.
  mla: Metzler, Sina, et al. “Mating and Longevity in Ant Males.” <i>Ecology and Evolution</i>,
    vol. 6, no. 24, Wiley-Blackwell, 2016, pp. 8903–06, doi:<a href="https://doi.org/10.1002/ece3.2474">10.1002/ece3.2474</a>.
  short: S. Metzler, J. Heinze, A. Schrempf, Ecology and Evolution 6 (2016) 8903–8906.
date_created: 2018-12-11T11:50:36Z
date_published: 2016-12-01T00:00:00Z
date_updated: 2025-09-22T09:47:16Z
day: '01'
ddc:
- '576'
- '592'
department:
- _id: SyCr
doi: 10.1002/ece3.2474
external_id:
  isi:
  - '000392063300022'
file:
- access_level: open_access
  checksum: 789026eb9e1be2a0da08376f29f569cf
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:12Z
  date_updated: 2020-07-14T12:44:37Z
  file_id: '5062'
  file_name: IST-2017-736-v1+1_Metzler_et_al-2016-Ecology_and_Evolution.pdf
  file_size: 328414
  relation: main_file
file_date_updated: 2020-07-14T12:44:37Z
fulldoi: https://doi.org/10.1002/ece3.2474
has_accepted_license: '1'
intvolume: '         6'
isi: 1
issue: '24'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 8903 - 8906
publication: Ecology and Evolution
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6169'
pubrep_id: '736'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mating and longevity in ant males
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 6
year: '2016'
...
---
_id: '1186'
abstract:
- lang: eng
  text: The human pathogen Streptococcus pneumoniae is decorated with a special class
    of surface-proteins known as choline-binding proteins (CBPs) attached to phosphorylcholine
    (PCho) moieties from cell-wall teichoic acids. By a combination of X-ray crystallography,
    NMR, molecular dynamics techniques and in vivo virulence and phagocytosis studies,
    we provide structural information of choline-binding protein L (CbpL) and demonstrate
    its impact on pneumococcal pathogenesis and immune evasion. CbpL is a very elongated
    three-module protein composed of (i) an Excalibur Ca 2+ -binding domain -reported
    in this work for the very first time-, (ii) an unprecedented anchorage module
    showing alternate disposition of canonical and non-canonical choline-binding sites
    that allows vine-like binding of fully-PCho-substituted teichoic acids (with two
    choline moieties per unit), and (iii) a Ltp-Lipoprotein domain. Our structural
    and infection assays indicate an important role of the whole multimodular protein
    allowing both to locate CbpL at specific places on the cell wall and to interact
    with host components in order to facilitate pneumococcal lung infection and transmigration
    from nasopharynx to the lungs and blood. CbpL implication in both resistance against
    killing by phagocytes and pneumococcal pathogenesis further postulate this surface-protein
    as relevant among the pathogenic arsenal of the pneumococcus.
acknowledgement: We gratefully acknowledge Karsta Barnekow and Kristine Sievert-Giermann,
  for technical assistance and Lothar Petruschka for in silico analysis (all Dept.
  of Genetics, University of Greifswald). We are further grateful to the staff from
  SLS synchrotron beamline for help in data collection. This work was supported by
  grants from the Deutsche Forschungsgemeinschaft DFG GRK 1870 (to SH) and the Spanish
  Ministry of Economy and Competitiveness (BFU2014-59389-P to JAH, CTQ2014-52633-P
  to MB and SAF2012-39760-C02-02 to FG) and S2010/BMD-2457 (Community of Madrid to
  JAH and FG).
article_number: '38094'
article_processing_charge: No
author:
- first_name: Javier
  full_name: Gutierrez-Fernandez, Javier
  id: 3D9511BA-F248-11E8-B48F-1D18A9856A87
  last_name: Gutierrez-Fernandez
- first_name: Malek
  full_name: Saleh, Malek
  last_name: Saleh
- first_name: Martín
  full_name: Alcorlo, Martín
  last_name: Alcorlo
- first_name: Alejandro
  full_name: Gómez Mejóa, Alejandro
  last_name: Gómez Mejóa
- first_name: David
  full_name: Pantoja Uceda, David
  last_name: Pantoja Uceda
- first_name: Miguel
  full_name: Treviño, Miguel
  last_name: Treviño
- first_name: Franziska
  full_name: Vob, Franziska
  last_name: Vob
- first_name: Mohammed
  full_name: Abdullah, Mohammed
  last_name: Abdullah
- first_name: Sergio
  full_name: Galán Bartual, Sergio
  last_name: Galán Bartual
- first_name: Jolien
  full_name: Seinen, Jolien
  last_name: Seinen
- first_name: Pedro
  full_name: Sánchez Murcia, Pedro
  last_name: Sánchez Murcia
- first_name: Federico
  full_name: Gago, Federico
  last_name: Gago
- first_name: Marta
  full_name: Bruix, Marta
  last_name: Bruix
- first_name: Sven
  full_name: Hammerschmidt, Sven
  last_name: Hammerschmidt
- first_name: Juan
  full_name: Hermoso, Juan
  last_name: Hermoso
citation:
  ama: Gutierrez-Fernandez J, Saleh M, Alcorlo M, et al. Modular architecture and
    unique teichoic acid recognition features of choline-binding protein L CbpL contributing
    to pneumococcal pathogenesis. <i>Scientific Reports</i>. 2016;6. doi:<a href="https://doi.org/10.1038/srep38094">10.1038/srep38094</a>
  apa: Gutierrez-Fernandez, J., Saleh, M., Alcorlo, M., Gómez Mejóa, A., Pantoja Uceda,
    D., Treviño, M., … Hermoso, J. (2016). Modular architecture and unique teichoic
    acid recognition features of choline-binding protein L CbpL contributing to pneumococcal
    pathogenesis. <i>Scientific Reports</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/srep38094">https://doi.org/10.1038/srep38094</a>
  chicago: Gutierrez-Fernandez, Javier, Malek Saleh, Martín Alcorlo, Alejandro Gómez
    Mejóa, David Pantoja Uceda, Miguel Treviño, Franziska Vob, et al. “Modular Architecture
    and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L CbpL
    Contributing to Pneumococcal Pathogenesis.” <i>Scientific Reports</i>. Nature
    Publishing Group, 2016. <a href="https://doi.org/10.1038/srep38094">https://doi.org/10.1038/srep38094</a>.
  ieee: J. Gutierrez-Fernandez <i>et al.</i>, “Modular architecture and unique teichoic
    acid recognition features of choline-binding protein L CbpL contributing to pneumococcal
    pathogenesis,” <i>Scientific Reports</i>, vol. 6. Nature Publishing Group, 2016.
  ista: Gutierrez-Fernandez J, Saleh M, Alcorlo M, Gómez Mejóa A, Pantoja Uceda D,
    Treviño M, Vob F, Abdullah M, Galán Bartual S, Seinen J, Sánchez Murcia P, Gago
    F, Bruix M, Hammerschmidt S, Hermoso J. 2016. Modular architecture and unique
    teichoic acid recognition features of choline-binding protein L CbpL contributing
    to pneumococcal pathogenesis. Scientific Reports. 6, 38094.
  mla: Gutierrez-Fernandez, Javier, et al. “Modular Architecture and Unique Teichoic
    Acid Recognition Features of Choline-Binding Protein L CbpL Contributing to Pneumococcal
    Pathogenesis.” <i>Scientific Reports</i>, vol. 6, 38094, Nature Publishing Group,
    2016, doi:<a href="https://doi.org/10.1038/srep38094">10.1038/srep38094</a>.
  short: J. Gutierrez-Fernandez, M. Saleh, M. Alcorlo, A. Gómez Mejóa, D. Pantoja
    Uceda, M. Treviño, F. Vob, M. Abdullah, S. Galán Bartual, J. Seinen, P. Sánchez
    Murcia, F. Gago, M. Bruix, S. Hammerschmidt, J. Hermoso, Scientific Reports 6
    (2016).
date_created: 2018-12-11T11:50:36Z
date_published: 2016-12-05T00:00:00Z
date_updated: 2025-09-22T09:46:12Z
day: '05'
ddc:
- '576'
- '610'
department:
- _id: LeSa
doi: 10.1038/srep38094
external_id:
  isi:
  - '000389129100001'
file:
- access_level: open_access
  checksum: e007d78b483bc59bf5ab98e9d42a6ec1
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:18Z
  date_updated: 2020-07-14T12:44:37Z
  file_id: '4804'
  file_name: IST-2017-735-v1+1_srep38094.pdf
  file_size: 2716045
  relation: main_file
file_date_updated: 2020-07-14T12:44:37Z
fulldoi: https://doi.org/10.1038/srep38094
has_accepted_license: '1'
intvolume: '         6'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Scientific Reports
publication_status: published
publisher: Nature Publishing Group
publist_id: '6167'
pubrep_id: '735'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modular architecture and unique teichoic acid recognition features of choline-binding
  protein L CbpL contributing to pneumococcal pathogenesis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 6
year: '2016'
...
---
_id: '11866'
abstract:
- lang: eng
  text: "We present a deterministic (1+o(1))-approximation O(n1/2+o(1)+D1+o(1))-time
    algorithm for solving the single-source shortest paths problem on distributed
    weighted networks (the CONGEST model); here n is the number of nodes in the network
    and D is its (hop) diameter. This is the first non-trivial deterministic algorithm
    for this problem. It also improves (i) the running time of the randomized (1+o(1))-approximation
    Õ(n1/2D1/4+D)-time algorithm of Nanongkai [STOC 2014] by a factor of as large
    as n1/8, and (ii) the O(є−1logє−1)-approximation factor of Lenzen and Patt-Shamir’s
    Õ(n1/2+є+D)-time algorithm [STOC 2013] within the same running time. Our running
    time matches the known time lower bound of Ω(n1/2/logn + D) [Das Sarma et al.
    STOC 2011] modulo some lower-order terms, thus essentially settling the status
    of this problem which was raised at least a decade ago [Elkin SIGACT News 2004].
    It also implies a (2+o(1))-approximation O(n1/2+o(1)+D1+o(1))-time algorithm for
    approximating a network’s weighted diameter which almost matches the lower bound
    by Holzer et al. [PODC 2012].\r\n\r\nIn achieving this result, we develop two
    techniques which might be of independent interest and useful in other settings:
    (i) a deterministic process that replaces the “hitting set argument” commonly
    used for shortest paths computation in various settings, and (ii) a simple, deterministic,
    construction of an (no(1), o(1))-hop set of size O(n1+o(1)). We combine these
    techniques with many distributed algorithmic techniques, some of which from problems
    that are not directly related to shortest paths, e.g. ruling sets [Goldberg et
    al. STOC 1987], source detection [Lenzen, Peleg PODC 2013], and partial distance
    estimation [Lenzen, Patt-Shamir PODC 2015]. Our hop set construction also leads
    to single-source shortest paths algorithms in two other settings: (i) a (1+o(1))-approximation
    O(no(1))-time algorithm on congested cliques, and (ii) a (1+o(1))-approximation
    O(no(1)logW)-pass O(n1+o(1)logW)-space streaming algorithm, when edge weights
    are in {1, 2, …, W}. The first result answers an open problem in [Nanongkai, STOC
    2014]. The second result partially answers an open problem raised by McGregor
    in 2006 [<pre>sublinear.info</pre>, Problem 14]."
article_processing_charge: No
arxiv: 1
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Sebastian
  full_name: Krinninger, Sebastian
  last_name: Krinninger
- first_name: Danupon
  full_name: Nanongkai, Danupon
  last_name: Nanongkai
citation:
  ama: 'Henzinger M, Krinninger S, Nanongkai D. A deterministic almost-tight distributed
    algorithm for approximating single-source shortest paths. In: <i>48th Annual ACM
    SIGACT Symposium on Theory of Computing</i>. Association for Computing Machinery;
    2016:489-498. doi:<a href="https://doi.org/10.1145/2897518.2897638">10.1145/2897518.2897638</a>'
  apa: 'Henzinger, M., Krinninger, S., &#38; Nanongkai, D. (2016). A deterministic
    almost-tight distributed algorithm for approximating single-source shortest paths.
    In <i>48th Annual ACM SIGACT Symposium on Theory of Computing</i> (pp. 489–498).
    Cambridge, MA, United States: Association for Computing Machinery. <a href="https://doi.org/10.1145/2897518.2897638">https://doi.org/10.1145/2897518.2897638</a>'
  chicago: Henzinger, Monika, Sebastian Krinninger, and Danupon Nanongkai. “A Deterministic
    Almost-Tight Distributed Algorithm for Approximating Single-Source Shortest Paths.”
    In <i>48th Annual ACM SIGACT Symposium on Theory of Computing</i>, 489–98. Association
    for Computing Machinery, 2016. <a href="https://doi.org/10.1145/2897518.2897638">https://doi.org/10.1145/2897518.2897638</a>.
  ieee: M. Henzinger, S. Krinninger, and D. Nanongkai, “A deterministic almost-tight
    distributed algorithm for approximating single-source shortest paths,” in <i>48th
    Annual ACM SIGACT Symposium on Theory of Computing</i>, Cambridge, MA, United
    States, 2016, pp. 489–498.
  ista: 'Henzinger M, Krinninger S, Nanongkai D. 2016. A deterministic almost-tight
    distributed algorithm for approximating single-source shortest paths. 48th Annual
    ACM SIGACT Symposium on Theory of Computing. STOC: Symposium on Theory of Computing,
    489–498.'
  mla: Henzinger, Monika, et al. “A Deterministic Almost-Tight Distributed Algorithm
    for Approximating Single-Source Shortest Paths.” <i>48th Annual ACM SIGACT Symposium
    on Theory of Computing</i>, Association for Computing Machinery, 2016, pp. 489–98,
    doi:<a href="https://doi.org/10.1145/2897518.2897638">10.1145/2897518.2897638</a>.
  short: M. Henzinger, S. Krinninger, D. Nanongkai, in:, 48th Annual ACM SIGACT Symposium
    on Theory of Computing, Association for Computing Machinery, 2016, pp. 489–498.
conference:
  end_date: 2016-06-21
  location: Cambridge, MA, United States
  name: 'STOC: Symposium on Theory of Computing'
  start_date: 2016-06-19
date_created: 2022-08-16T09:19:31Z
date_published: 2016-06-01T00:00:00Z
date_updated: 2024-11-06T12:19:26Z
day: '01'
doi: 10.1145/2897518.2897638
extern: '1'
external_id:
  arxiv:
  - '1504.07056'
fulldoi: https://doi.org/10.1145/2897518.2897638
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1504.07056
month: '06'
oa: 1
oa_version: Preprint
page: 489 - 498
publication: 48th Annual ACM SIGACT Symposium on Theory of Computing
publication_identifier:
  isbn:
  - 978-145034132-5
  issn:
  - 0737-8017
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: A deterministic almost-tight distributed algorithm for approximating single-source
  shortest paths
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2016'
...
---
_id: '11867'
abstract:
- lang: eng
  text: We present two deterministic dynamic algorithms for the maximum matching problem.
    (1) An algorithm that maintains a (2+є)-approximate maximum matching in general
    graphs with O(poly(logn, 1/є)) update time. (2) An algorithm that maintains an
    αK approximation of the value of the maximum matching with O(n2/K) update time
    in bipartite graphs, for every sufficiently large constant positive integer K.
    Here, 1≤ αK < 2 is a constant determined by the value of K. Result (1) is the
    first deterministic algorithm that can maintain an o(logn)-approximate maximum
    matching with polylogarithmic update time, improving the seminal result of Onak
    et al. [STOC 2010]. Its approximation guarantee almost matches the guarantee of
    the best randomized polylogarithmic update time algorithm [Baswana et al. FOCS
    2011]. Result (2) achieves a better-than-two approximation with arbitrarily small
    polynomial update time on bipartite graphs. Previously the best update time for
    this problem was O(m1/4) [Bernstein et al. ICALP 2015], where m is the current
    number of edges in the graph.
article_processing_charge: No
arxiv: 1
author:
- first_name: Sayan
  full_name: Bhattacharya, Sayan
  last_name: Bhattacharya
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Danupon
  full_name: Nanongkai, Danupon
  last_name: Nanongkai
citation:
  ama: 'Bhattacharya S, Henzinger M, Nanongkai D. New deterministic approximation
    algorithms for fully dynamic matching. In: <i>48th Annual ACM SIGACT Symposium
    on Theory of Computing</i>. Association for Computing Machinery; 2016:398-411.
    doi:<a href="https://doi.org/10.1145/2897518.2897568">10.1145/2897518.2897568</a>'
  apa: 'Bhattacharya, S., Henzinger, M., &#38; Nanongkai, D. (2016). New deterministic
    approximation algorithms for fully dynamic matching. In <i>48th Annual ACM SIGACT
    Symposium on Theory of Computing</i> (pp. 398–411). Cambridge, MA, United States:
    Association for Computing Machinery. <a href="https://doi.org/10.1145/2897518.2897568">https://doi.org/10.1145/2897518.2897568</a>'
  chicago: Bhattacharya, Sayan, Monika Henzinger, and Danupon Nanongkai. “New Deterministic
    Approximation Algorithms for Fully Dynamic Matching.” In <i>48th Annual ACM SIGACT
    Symposium on Theory of Computing</i>, 398–411. Association for Computing Machinery,
    2016. <a href="https://doi.org/10.1145/2897518.2897568">https://doi.org/10.1145/2897518.2897568</a>.
  ieee: S. Bhattacharya, M. Henzinger, and D. Nanongkai, “New deterministic approximation
    algorithms for fully dynamic matching,” in <i>48th Annual ACM SIGACT Symposium
    on Theory of Computing</i>, Cambridge, MA, United States, 2016, pp. 398–411.
  ista: 'Bhattacharya S, Henzinger M, Nanongkai D. 2016. New deterministic approximation
    algorithms for fully dynamic matching. 48th Annual ACM SIGACT Symposium on Theory
    of Computing. STOC: Symposium on Theory of Computing, 398–411.'
  mla: Bhattacharya, Sayan, et al. “New Deterministic Approximation Algorithms for
    Fully Dynamic Matching.” <i>48th Annual ACM SIGACT Symposium on Theory of Computing</i>,
    Association for Computing Machinery, 2016, pp. 398–411, doi:<a href="https://doi.org/10.1145/2897518.2897568">10.1145/2897518.2897568</a>.
  short: S. Bhattacharya, M. Henzinger, D. Nanongkai, in:, 48th Annual ACM SIGACT
    Symposium on Theory of Computing, Association for Computing Machinery, 2016, pp.
    398–411.
conference:
  end_date: 2016-06-21
  location: Cambridge, MA, United States
  name: 'STOC: Symposium on Theory of Computing'
  start_date: 2016-06-19
date_created: 2022-08-16T09:27:35Z
date_published: 2016-06-01T00:00:00Z
date_updated: 2024-11-06T12:19:37Z
day: '01'
doi: 10.1145/2897518.2897568
extern: '1'
external_id:
  arxiv:
  - '1604.05765'
fulldoi: https://doi.org/10.1145/2897518.2897568
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1604.05765
month: '06'
oa: 1
oa_version: Preprint
page: 398 - 411
publication: 48th Annual ACM SIGACT Symposium on Theory of Computing
publication_identifier:
  isbn:
  - 978-145034132-5
  issn:
  - 0737-8017
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: New deterministic approximation algorithms for fully dynamic matching
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2016'
...
---
_id: '1189'
abstract:
- lang: eng
  text: "Within the scope of this thesis,  we show that a driven-dissipative system
    with\r\nfew ultracold atoms can exhibit dissipatively bound states, even if the
    atom-atom\r\ninteraction is purely repulsive.  This bond arises due to the dipole-dipole
    inter-\r\naction, which is restricted to one of the lower electronic energy states,
    resulting\r\nin the distance-dependent coherent population trapping.  The quality
    of this al-\r\nready established method of dissipative binding is improved and
    the application\r\nis extended to higher dimensions and a larger number of atoms.
    \ Here, we simu-\r\nlate two- and three-atom systems using an adapted approach
    to the Monte Carlo\r\nwave-function  method  and  analyse  the  results.   Finally,
    \ we  examine  the  possi-\r\nbility  of  finding  a  setting  allowing  trimer
    \ states  but  prohibiting  dimer  states.\r\nIn the context of open quantum systems,
    such a three-body bound states corre-\r\nsponds to the driven-dissipative analogue
    of a Borromean state.  These states can\r\nbe detected in modern experiments with
    dipolar and Rydberg-dressed ultracold\r\natomic gases.\r\n"
article_processing_charge: No
author:
- first_name: Clemens
  full_name: Jochum, Clemens
  last_name: Jochum
citation:
  ama: Jochum C. Dissipative Few-Body Quantum Systems. 2016.
  apa: Jochum, C. (2016). <i>Dissipative Few-Body Quantum Systems</i>. Technical University
    Vienna.
  chicago: Jochum, Clemens. “Dissipative Few-Body Quantum Systems.” Technical University
    Vienna, 2016.
  ieee: C. Jochum, “Dissipative Few-Body Quantum Systems,” Technical University Vienna,
    2016.
  ista: Jochum C. 2016. Dissipative Few-Body Quantum Systems. Technical University
    Vienna.
  mla: Jochum, Clemens. <i>Dissipative Few-Body Quantum Systems</i>. Technical University
    Vienna, 2016.
  short: C. Jochum, Dissipative Few-Body Quantum Systems, Technical University Vienna,
    2016.
date_created: 2018-12-11T11:50:37Z
date_published: 2016-11-28T00:00:00Z
date_updated: 2021-01-12T06:48:57Z
day: '28'
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://repositum.tuwien.ac.at/obvutwhs/content/titleinfo/1517088
month: '11'
oa: 1
oa_version: Published Version
page: '94'
publication_status: published
publisher: Technical University Vienna
publist_id: '6164'
status: public
supervisor:
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
- first_name: Peter
  full_name: Rabl, Peter
  last_name: Rabl
title: Dissipative Few-Body Quantum Systems
type: dissertation
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2016'
...
---
_id: '11891'
abstract:
- lang: eng
  text: "We study dynamic (1+\U0001D716)-approximation algorithms for the all-pairs
    shortest paths problem in unweighted undirected \U0001D45B-node \U0001D45A-edge
    graphs under edge deletions. The fastest algorithm for this problem is a randomized
    algorithm with a total update time of \U0001D442̃ (\U0001D45A\U0001D45B/\U0001D716)
    and constant query time by Roditty and Zwick [SIAM J. Comput., 41 (2012), pp.
    670--683]. The fastest deterministic algorithm is from a 1981 paper by Even and
    Shiloach [J. ACM, 28 (1981), pp. 1--4]; it has a total update time of \U0001D442(\U0001D45A\U0001D45B2)
    and constant query time. We improve these results as follows: (1) We present an
    algorithm with a total update time of \U0001D442̃ (\U0001D45B5/2/\U0001D716) and
    constant query time that has an additive error of 2 in addition to the 1+\U0001D716
    multiplicative error. This beats the previous \U0001D442̃ (\U0001D45A\U0001D45B/\U0001D716)
    time when \U0001D45A=Ω(\U0001D45B3/2). Note that the additive error is unavoidable
    since, even in the static case, an \U0001D442(\U0001D45B3−\U0001D6FF)-time (a
    so-called truly subcubic) combinatorial algorithm with 1+\U0001D716 multiplicative
    error cannot have an additive error less than 2−\U0001D716, unless we make a major
    breakthrough for Boolean matrix multiplication [D. Dor, S. Halrepin, and U. Zwick,
    SIAM J. Comput., 29 (2000), pp. 1740--1759] and many other long-standing problems
    [V. Vassilevska Williams and R. Williams, Proceedings of the 2010 IEEE 51st Annual
    Symposium on Foundations of Computer Science, 2010, pp. 645--654]. The algorithm
    can also be turned into a (2+\U0001D716)-approximation algorithm (without an additive
    error) with the same time guarantees, improving the recent (3+\U0001D716)-approximation
    algorithm with \U0001D442̃ (\U0001D45B5/2+\U0001D442(log(1/\U0001D716)/log\U0001D45B√))
    running time of Bernstein and Roditty [Proceedings of the Twenty-Second Annual
    ACM-SIAM Symposium on Discrete Algorithms, 2011, pp. 1355--1365] in terms of both
    approximation and time guarantees. (2) We present a deterministic algorithm with
    a total update time of \U0001D442̃ (\U0001D45A\U0001D45B/\U0001D716) and a query
    time of \U0001D442(loglog\U0001D45B). The algorithm has a multiplicative error
    of 1+\U0001D716 and gives the first improved deterministic algorithm since 1981.
    It also answers an open question raised by Bernstein in [Proceedings of the Forty-Fifth
    Annual ACM Symposium on Theory of Computing, 2013, pp. 725--734]. The deterministic
    algorithm can be turned into a deterministic fully dynamic (1+\U0001D716)-approximation
    with an amortized update time of \U0001D442̃ (\U0001D45A\U0001D45B/(\U0001D716\U0001D461))
    and a query time of \U0001D442̃ (\U0001D461) for every \U0001D461≤\U0001D45B√.
    In order to achieve our results, we introduce two new techniques: (i) A monotone
    Even--Shiloach tree algorithm which maintains a bounded-distance shortest-paths
    tree on a certain type of emulator called a locally persevering emulator. (ii)
    A derandomization technique based on moving Even--Shiloach trees as a way to derandomize
    the standard random set argument. These techniques might be of independent interest."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Sebastian
  full_name: Krinninger, Sebastian
  last_name: Krinninger
- first_name: Danupon
  full_name: Nanongkai, Danupon
  last_name: Nanongkai
citation:
  ama: 'Henzinger M, Krinninger S, Nanongkai D. Dynamic approximate all-pairs shortest
    paths: Breaking the O(mn) barrier and derandomization. <i>SIAM Journal on Computing</i>.
    2016;45(3):947-1006. doi:<a href="https://doi.org/10.1137/140957299">10.1137/140957299</a>'
  apa: 'Henzinger, M., Krinninger, S., &#38; Nanongkai, D. (2016). Dynamic approximate
    all-pairs shortest paths: Breaking the O(mn) barrier and derandomization. <i>SIAM
    Journal on Computing</i>. Society for Industrial &#38; Applied Mathematics. <a
    href="https://doi.org/10.1137/140957299">https://doi.org/10.1137/140957299</a>'
  chicago: 'Henzinger, Monika, Sebastian Krinninger, and Danupon Nanongkai. “Dynamic
    Approximate All-Pairs Shortest Paths: Breaking the O(Mn) Barrier and Derandomization.”
    <i>SIAM Journal on Computing</i>. Society for Industrial &#38; Applied Mathematics,
    2016. <a href="https://doi.org/10.1137/140957299">https://doi.org/10.1137/140957299</a>.'
  ieee: 'M. Henzinger, S. Krinninger, and D. Nanongkai, “Dynamic approximate all-pairs
    shortest paths: Breaking the O(mn) barrier and derandomization,” <i>SIAM Journal
    on Computing</i>, vol. 45, no. 3. Society for Industrial &#38; Applied Mathematics,
    pp. 947–1006, 2016.'
  ista: 'Henzinger M, Krinninger S, Nanongkai D. 2016. Dynamic approximate all-pairs
    shortest paths: Breaking the O(mn) barrier and derandomization. SIAM Journal on
    Computing. 45(3), 947–1006.'
  mla: 'Henzinger, Monika, et al. “Dynamic Approximate All-Pairs Shortest Paths: Breaking
    the O(Mn) Barrier and Derandomization.” <i>SIAM Journal on Computing</i>, vol.
    45, no. 3, Society for Industrial &#38; Applied Mathematics, 2016, pp. 947–1006,
    doi:<a href="https://doi.org/10.1137/140957299">10.1137/140957299</a>.'
  short: M. Henzinger, S. Krinninger, D. Nanongkai, SIAM Journal on Computing 45 (2016)
    947–1006.
date_created: 2022-08-17T08:37:00Z
date_published: 2016-05-01T00:00:00Z
date_updated: 2024-11-06T12:23:06Z
day: '01'
doi: 10.1137/140957299
extern: '1'
external_id:
  arxiv:
  - '1308.0776'
fulldoi: https://doi.org/10.1137/140957299
intvolume: '        45'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1308.0776
month: '05'
oa: 1
oa_version: Preprint
page: 947-1006
publication: SIAM Journal on Computing
publication_identifier:
  eissn:
  - 1095-7111
  issn:
  - 0097-5397
publication_status: published
publisher: Society for Industrial & Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Dynamic approximate all-pairs shortest paths: Breaking the O(mn) barrier and
  derandomization'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 45
year: '2016'
...
---
_id: '1193'
abstract:
- lang: eng
  text: We consider the recent formulation of the Algorithmic Lovász Local Lemma [1],
    [2] for finding objects that avoid &quot;bad features&quot;, or &quot;flaws&quot;.
    It extends the Moser-Tardos resampling algorithm [3] to more general discrete
    spaces. At each step the method picks a flaw present in the current state and
    &quot;resamples&quot; it using a &quot;resampling oracle&quot; provided by the
    user. However, it is less flexible than the Moser-Tardos method since [1], [2]
    require a specific flaw selection rule, whereas [3] allows an arbitrary rule (and
    thus can potentially be implemented more efficiently). We formulate a new &quot;commutativity&quot;
    condition, and prove that it is sufficient for an arbitrary rule to work. It also
    enables an efficient parallelization under an additional assumption. We then show
    that existing resampling oracles for perfect matchings and permutations do satisfy
    this condition. Finally, we generalize the precondition in [2] (in the case of
    symmetric potential causality graphs). This unifies special cases that previously
    were treated separately.
acknowledgement: European Unions Seventh Framework Programme (FP7/2007-2013)/ERC grant
  agreement no 616160
article_number: '7782993'
article_processing_charge: No
arxiv: 1
author:
- first_name: Vladimir
  full_name: Kolmogorov, Vladimir
  id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
  last_name: Kolmogorov
citation:
  ama: 'Kolmogorov V. Commutativity in the algorithmic Lovasz local lemma. In: <i>Proceedings
    - Annual IEEE Symposium on Foundations of Computer Science</i>. Vol 2016-December.
    IEEE; 2016. doi:<a href="https://doi.org/10.1109/FOCS.2016.88">10.1109/FOCS.2016.88</a>'
  apa: 'Kolmogorov, V. (2016). Commutativity in the algorithmic Lovasz local lemma.
    In <i>Proceedings - Annual IEEE Symposium on Foundations of Computer Science</i>
    (Vol. 2016–December). New Brunswick, NJ, USA : IEEE. <a href="https://doi.org/10.1109/FOCS.2016.88">https://doi.org/10.1109/FOCS.2016.88</a>'
  chicago: Kolmogorov, Vladimir. “Commutativity in the Algorithmic Lovasz Local Lemma.”
    In <i>Proceedings - Annual IEEE Symposium on Foundations of Computer Science</i>,
    Vol. 2016–December. IEEE, 2016. <a href="https://doi.org/10.1109/FOCS.2016.88">https://doi.org/10.1109/FOCS.2016.88</a>.
  ieee: V. Kolmogorov, “Commutativity in the algorithmic Lovasz local lemma,” in <i>Proceedings
    - Annual IEEE Symposium on Foundations of Computer Science</i>, New Brunswick,
    NJ, USA , 2016, vol. 2016–December.
  ista: 'Kolmogorov V. 2016. Commutativity in the algorithmic Lovasz local lemma.
    Proceedings - Annual IEEE Symposium on Foundations of Computer Science. FOCS:
    Foundations of Computer Science vol. 2016–December, 7782993.'
  mla: Kolmogorov, Vladimir. “Commutativity in the Algorithmic Lovasz Local Lemma.”
    <i>Proceedings - Annual IEEE Symposium on Foundations of Computer Science</i>,
    vol. 2016–December, 7782993, IEEE, 2016, doi:<a href="https://doi.org/10.1109/FOCS.2016.88">10.1109/FOCS.2016.88</a>.
  short: V. Kolmogorov, in:, Proceedings - Annual IEEE Symposium on Foundations of
    Computer Science, IEEE, 2016.
conference:
  end_date: 2016-09-11
  location: 'New Brunswick, NJ, USA '
  name: 'FOCS: Foundations of Computer Science'
  start_date: 2016-09-09
date_created: 2018-12-11T11:50:38Z
date_published: 2016-12-15T00:00:00Z
date_updated: 2025-09-22T09:44:20Z
day: '15'
department:
- _id: VlKo
doi: 10.1109/FOCS.2016.88
ec_funded: 1
external_id:
  arxiv:
  - '1506.08547'
  isi:
  - '000391198500082'
fulldoi: https://doi.org/10.1109/FOCS.2016.88
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1506.08547v7
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 25FBA906-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '616160'
  name: 'Discrete Optimization in Computer Vision: Theory and Practice'
publication: Proceedings - Annual IEEE Symposium on Foundations of Computer Science
publication_status: published
publisher: IEEE
publist_id: '6158'
quality_controlled: '1'
related_material:
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title: Commutativity in the algorithmic Lovasz local lemma
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 2016-December
year: '2016'
...
---
_id: '1195'
abstract:
- lang: eng
  text: 'The genetic analysis of experimentally evolving populations typically relies
    on short reads from pooled individuals (Pool-Seq). While this method provides
    reliable allele frequency estimates, the underlying haplotype structure remains
    poorly characterized. With small population sizes and adaptive variants that start
    from low frequencies, the interpretation of selection signatures in most Evolve
    and Resequencing studies remains challenging. To facilitate the characterization
    of selection targets, we propose a new approach that reconstructs selected haplotypes
    from replicated time series, using Pool-Seq data. We identify selected haplotypes
    through the correlated frequencies of alleles carried by them. Computer simulations
    indicate that selected haplotype-blocks of several Mb can be reconstructed with
    high confidence and low error rates, even when allele frequencies change only
    by 20% across three replicates. Applying this method to real data from D. melanogaster
    populations adapting to a hot environment, we identify a selected haplotype-block
    of 6.93 Mb. We confirm the presence of this haplotype-block in evolved populations
    by experimental haplotyping, demonstrating the power and accuracy of our haplotype
    reconstruction from Pool-Seq data. We propose that the combination of allele frequency
    estimates with haplotype information will provide the key to understanding the
    dynamics of adaptive alleles. '
acknowledgement: "The authors thank all members of the Institute of Population\r\nGenetics
  for discussion and support on the project and par-\r\nticularly N. Barghi for helpful
  comments on earlier versions of\r\nthe  manuscript.  This  work  was  supported
  \ by  the  European\r\nResearch Council (ERC) grants “ArchAdapt” and “250152”."
article_processing_charge: No
author:
- first_name: Susan
  full_name: Franssen, Susan
  last_name: Franssen
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Christian
  full_name: Schlötterer, Christian
  last_name: Schlötterer
citation:
  ama: Franssen S, Barton NH, Schlötterer C. Reconstruction of haplotype-blocks selected
    during experimental evolution. <i>Molecular Biology and Evolution</i>. 2016;34(1):174-184.
    doi:<a href="https://doi.org/10.1093/molbev/msw210">10.1093/molbev/msw210</a>
  apa: Franssen, S., Barton, N. H., &#38; Schlötterer, C. (2016). Reconstruction of
    haplotype-blocks selected during experimental evolution. <i>Molecular Biology
    and Evolution</i>. Oxford University Press. <a href="https://doi.org/10.1093/molbev/msw210">https://doi.org/10.1093/molbev/msw210</a>
  chicago: Franssen, Susan, Nicholas H Barton, and Christian Schlötterer. “Reconstruction
    of Haplotype-Blocks Selected during Experimental Evolution.” <i>Molecular Biology
    and Evolution</i>. Oxford University Press, 2016. <a href="https://doi.org/10.1093/molbev/msw210">https://doi.org/10.1093/molbev/msw210</a>.
  ieee: S. Franssen, N. H. Barton, and C. Schlötterer, “Reconstruction of haplotype-blocks
    selected during experimental evolution.,” <i>Molecular Biology and Evolution</i>,
    vol. 34, no. 1. Oxford University Press, pp. 174–184, 2016.
  ista: Franssen S, Barton NH, Schlötterer C. 2016. Reconstruction of haplotype-blocks
    selected during experimental evolution. Molecular Biology and Evolution. 34(1),
    174–184.
  mla: Franssen, Susan, et al. “Reconstruction of Haplotype-Blocks Selected during
    Experimental Evolution.” <i>Molecular Biology and Evolution</i>, vol. 34, no.
    1, Oxford University Press, 2016, pp. 174–84, doi:<a href="https://doi.org/10.1093/molbev/msw210">10.1093/molbev/msw210</a>.
  short: S. Franssen, N.H. Barton, C. Schlötterer, Molecular Biology and Evolution
    34 (2016) 174–184.
date_created: 2018-12-11T11:50:39Z
date_published: 2016-10-03T00:00:00Z
date_updated: 2025-09-22T09:43:41Z
day: '03'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1093/molbev/msw210
ec_funded: 1
external_id:
  isi:
  - '000396772000009'
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has_accepted_license: '1'
intvolume: '        34'
isi: 1
issue: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
page: 174 - 184
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '250152'
  name: Limits to selection in biology and in evolutionary computation
publication: Molecular Biology and Evolution
publication_status: published
publisher: Oxford University Press
publist_id: '6155'
pubrep_id: '770'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reconstruction of haplotype-blocks selected during experimental evolution.
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 34
year: '2016'
...
---
_id: '1197'
abstract:
- lang: eng
  text: Across the nervous system, certain population spiking patterns are observed
    far more frequently than others. A hypothesis about this structure is that these
    collective activity patterns function as population codewords–collective modes–carrying
    information distinct from that of any single cell. We investigate this phenomenon
    in recordings of ∼150 retinal ganglion cells, the retina’s output. We develop
    a novel statistical model that decomposes the population response into modes;
    it predicts the distribution of spiking activity in the ganglion cell population
    with high accuracy. We found that the modes represent localized features of the
    visual stimulus that are distinct from the features represented by single neurons.
    Modes form clusters of activity states that are readily discriminated from one
    another. When we repeated the same visual stimulus, we found that the same mode
    was robustly elicited. These results suggest that retinal ganglion cells’ collective
    signaling is endowed with a form of error-correcting code–a principle that may
    hold in brain areas beyond retina.
acknowledgement: JSP was supported by a C.V. Starr Fellowship from the Starr Foundation
  (http://www.starrfoundation.org/). GT was supported by Austrian Research Foundation
  (https://www.fwf.ac.at/en/) grant FWF P25651. MJB received support from National
  Eye Institute (https://nei.nih.gov/) grant EY 14196 and from the National Science
  Foundation grant 1504977. The authors thank Cristina Savin and Vicent Botella-Soler
  for helpful comments on the manuscript.
article_number: e1005855
article_processing_charge: No
author:
- first_name: Jason
  full_name: Prentice, Jason
  last_name: Prentice
- first_name: Olivier
  full_name: Marre, Olivier
  last_name: Marre
- first_name: Mark
  full_name: Ioffe, Mark
  last_name: Ioffe
- first_name: Adrianna
  full_name: Loback, Adrianna
  last_name: Loback
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: Michael
  full_name: Berry, Michael
  last_name: Berry
citation:
  ama: Prentice J, Marre O, Ioffe M, Loback A, Tkačik G, Berry M. Error-robust modes
    of the retinal population code. <i>PLoS Computational Biology</i>. 2016;12(11).
    doi:<a href="https://doi.org/10.1371/journal.pcbi.1005148">10.1371/journal.pcbi.1005148</a>
  apa: Prentice, J., Marre, O., Ioffe, M., Loback, A., Tkačik, G., &#38; Berry, M.
    (2016). Error-robust modes of the retinal population code. <i>PLoS Computational
    Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pcbi.1005148">https://doi.org/10.1371/journal.pcbi.1005148</a>
  chicago: Prentice, Jason, Olivier Marre, Mark Ioffe, Adrianna Loback, Gašper Tkačik,
    and Michael Berry. “Error-Robust Modes of the Retinal Population Code.” <i>PLoS
    Computational Biology</i>. Public Library of Science, 2016. <a href="https://doi.org/10.1371/journal.pcbi.1005148">https://doi.org/10.1371/journal.pcbi.1005148</a>.
  ieee: J. Prentice, O. Marre, M. Ioffe, A. Loback, G. Tkačik, and M. Berry, “Error-robust
    modes of the retinal population code,” <i>PLoS Computational Biology</i>, vol.
    12, no. 11. Public Library of Science, 2016.
  ista: Prentice J, Marre O, Ioffe M, Loback A, Tkačik G, Berry M. 2016. Error-robust
    modes of the retinal population code. PLoS Computational Biology. 12(11), e1005855.
  mla: Prentice, Jason, et al. “Error-Robust Modes of the Retinal Population Code.”
    <i>PLoS Computational Biology</i>, vol. 12, no. 11, e1005855, Public Library of
    Science, 2016, doi:<a href="https://doi.org/10.1371/journal.pcbi.1005148">10.1371/journal.pcbi.1005148</a>.
  short: J. Prentice, O. Marre, M. Ioffe, A. Loback, G. Tkačik, M. Berry, PLoS Computational
    Biology 12 (2016).
date_created: 2018-12-11T11:50:40Z
date_published: 2016-11-17T00:00:00Z
date_updated: 2025-09-22T09:43:12Z
day: '17'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1371/journal.pcbi.1005148
external_id:
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  - '000391230900008'
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  file_id: '5884'
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  file_size: 4492021
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file_date_updated: 2020-07-14T12:44:38Z
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isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 254D1A94-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 25651-N26
  name: Sensitivity to higher-order statistics in natural scenes
publication: PLoS Computational Biology
publication_status: published
publisher: Public Library of Science
publist_id: '6153'
quality_controlled: '1'
related_material:
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  - id: '9709'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Error-robust modes of the retinal population code
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 12
year: '2016'
...
---
_id: '1200'
acknowledgement: C.H. acknowledges generous support from the ISTFELLOW program.
article_processing_charge: No
author:
- first_name: Christian
  full_name: Hilbe, Christian
  id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
  last_name: Hilbe
  orcid: 0000-0001-5116-955X
- first_name: Arne
  full_name: Traulsen, Arne
  last_name: Traulsen
citation:
  ama: 'Hilbe C, Traulsen A. Only the combination of mathematics and agent based simulations
    can leverage the full potential of evolutionary modeling: Comment on “Evolutionary
    game theory using agent-based methods” by C. Adami, J. Schossau and A. Hintze.
    <i>Physics of Life Reviews</i>. 2016;19:29-31. doi:<a href="https://doi.org/10.1016/j.plrev.2016.10.004">10.1016/j.plrev.2016.10.004</a>'
  apa: 'Hilbe, C., &#38; Traulsen, A. (2016). Only the combination of mathematics
    and agent based simulations can leverage the full potential of evolutionary modeling:
    Comment on “Evolutionary game theory using agent-based methods” by C. Adami, J.
    Schossau and A. Hintze. <i>Physics of Life Reviews</i>. Elsevier. <a href="https://doi.org/10.1016/j.plrev.2016.10.004">https://doi.org/10.1016/j.plrev.2016.10.004</a>'
  chicago: 'Hilbe, Christian, and Arne Traulsen. “Only the Combination of Mathematics
    and Agent Based Simulations Can Leverage the Full Potential of Evolutionary Modeling:
    Comment on ‘Evolutionary Game Theory Using Agent-Based Methods’ by C. Adami, J.
    Schossau and A. Hintze.” <i>Physics of Life Reviews</i>. Elsevier, 2016. <a href="https://doi.org/10.1016/j.plrev.2016.10.004">https://doi.org/10.1016/j.plrev.2016.10.004</a>.'
  ieee: 'C. Hilbe and A. Traulsen, “Only the combination of mathematics and agent
    based simulations can leverage the full potential of evolutionary modeling: Comment
    on ‘Evolutionary game theory using agent-based methods’ by C. Adami, J. Schossau
    and A. Hintze,” <i>Physics of Life Reviews</i>, vol. 19. Elsevier, pp. 29–31,
    2016.'
  ista: 'Hilbe C, Traulsen A. 2016. Only the combination of mathematics and agent
    based simulations can leverage the full potential of evolutionary modeling: Comment
    on “Evolutionary game theory using agent-based methods” by C. Adami, J. Schossau
    and A. Hintze. Physics of Life Reviews. 19, 29–31.'
  mla: 'Hilbe, Christian, and Arne Traulsen. “Only the Combination of Mathematics
    and Agent Based Simulations Can Leverage the Full Potential of Evolutionary Modeling:
    Comment on ‘Evolutionary Game Theory Using Agent-Based Methods’ by C. Adami, J.
    Schossau and A. Hintze.” <i>Physics of Life Reviews</i>, vol. 19, Elsevier, 2016,
    pp. 29–31, doi:<a href="https://doi.org/10.1016/j.plrev.2016.10.004">10.1016/j.plrev.2016.10.004</a>.'
  short: C. Hilbe, A. Traulsen, Physics of Life Reviews 19 (2016) 29–31.
date_created: 2018-12-11T11:50:40Z
date_published: 2016-12-01T00:00:00Z
date_updated: 2025-09-22T09:42:11Z
day: '01'
ddc:
- '530'
department:
- _id: KrCh
doi: 10.1016/j.plrev.2016.10.004
ec_funded: 1
external_id:
  isi:
  - '000390640200003'
file:
- access_level: open_access
  checksum: 95e6dc78278334b99dacbf8822509364
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:11:02Z
  date_updated: 2020-07-14T12:44:39Z
  file_id: '4855'
  file_name: IST-2017-798-v1+1_comment_adami.pdf
  file_size: 171352
  relation: main_file
file_date_updated: 2020-07-14T12:44:39Z
fulldoi: https://doi.org/10.1016/j.plrev.2016.10.004
has_accepted_license: '1'
intvolume: '        19'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Submitted Version
page: 29 - 31
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Physics of Life Reviews
publication_status: published
publisher: Elsevier
publist_id: '6150'
pubrep_id: '798'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Only the combination of mathematics and agent based simulations can leverage
  the full potential of evolutionary modeling: Comment on “Evolutionary game theory
  using agent-based methods” by C. Adami, J. Schossau and A. Hintze'
tmp:
  image: /images/cc_by_nc_nd.png
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  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 19
year: '2016'
...
---
_id: '1202'
acknowledgement: The authors thank Sophie A.O. Armitage and Jan N. Offenborn for helpful
  comments on the figures, and two anonymous reviewers for their helpful comments.
  The project was funded by the Deutsche Forschungsgemeinschaft (DFG, KU 1929/4-2)
  within the priority programme SPP 1399 “Host–Parasite Coevolution”.
article_processing_charge: No
author:
- first_name: Barbara
  full_name: Milutinovic, Barbara
  id: 2CDC32B8-F248-11E8-B48F-1D18A9856A87
  last_name: Milutinovic
  orcid: 0000-0002-8214-4758
- first_name: Robert
  full_name: Peuß, Robert
  last_name: Peuß
- first_name: Kevin
  full_name: Ferro, Kevin
  last_name: Ferro
- first_name: Joachim
  full_name: Kurtz, Joachim
  last_name: Kurtz
citation:
  ama: 'Milutinovic B, Peuß R, Ferro K, Kurtz J. Immune priming in arthropods: an
    update focusing on the red flour beetle. <i>Zoology </i>. 2016;119(4):254-261.
    doi:<a href="https://doi.org/10.1016/j.zool.2016.03.006">10.1016/j.zool.2016.03.006</a>'
  apa: 'Milutinovic, B., Peuß, R., Ferro, K., &#38; Kurtz, J. (2016). Immune priming
    in arthropods: an update focusing on the red flour beetle. <i>Zoology </i>. Elsevier.
    <a href="https://doi.org/10.1016/j.zool.2016.03.006">https://doi.org/10.1016/j.zool.2016.03.006</a>'
  chicago: 'Milutinovic, Barbara, Robert Peuß, Kevin Ferro, and Joachim Kurtz. “Immune
    Priming in Arthropods: An Update Focusing on the Red Flour Beetle.” <i>Zoology
    </i>. Elsevier, 2016. <a href="https://doi.org/10.1016/j.zool.2016.03.006">https://doi.org/10.1016/j.zool.2016.03.006</a>.'
  ieee: 'B. Milutinovic, R. Peuß, K. Ferro, and J. Kurtz, “Immune priming in arthropods:
    an update focusing on the red flour beetle,” <i>Zoology </i>, vol. 119, no. 4.
    Elsevier, pp. 254–261, 2016.'
  ista: 'Milutinovic B, Peuß R, Ferro K, Kurtz J. 2016. Immune priming in arthropods:
    an update focusing on the red flour beetle. Zoology . 119(4), 254–261.'
  mla: 'Milutinovic, Barbara, et al. “Immune Priming in Arthropods: An Update Focusing
    on the Red Flour Beetle.” <i>Zoology </i>, vol. 119, no. 4, Elsevier, 2016, pp.
    254–61, doi:<a href="https://doi.org/10.1016/j.zool.2016.03.006">10.1016/j.zool.2016.03.006</a>.'
  short: B. Milutinovic, R. Peuß, K. Ferro, J. Kurtz, Zoology  119 (2016) 254–261.
date_created: 2018-12-11T11:50:41Z
date_published: 2016-08-01T00:00:00Z
date_updated: 2025-09-22T09:41:02Z
day: '01'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1016/j.zool.2016.03.006
external_id:
  isi:
  - '000384958500003'
file:
- access_level: open_access
  checksum: 8396d5bd95f9c4295857162f902afabf
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-01-25T13:00:20Z
  date_updated: 2020-07-14T12:44:39Z
  file_id: '5885'
  file_name: 2016_Elsevier_Milutinovic.pdf
  file_size: 1473211
  relation: main_file
file_date_updated: 2020-07-14T12:44:39Z
fulldoi: https://doi.org/10.1016/j.zool.2016.03.006
has_accepted_license: '1'
intvolume: '       119'
isi: 1
issue: '4'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 254 - 261
project:
- _id: 25DAF0B2-B435-11E9-9278-68D0E5697425
  grant_number: CR-118/3-1
  name: Host-Parasite Coevolution
publication: 'Zoology '
publication_status: published
publisher: Elsevier
publist_id: '6147'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Immune priming in arthropods: an update focusing on the red flour beetle'
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 119
year: '2016'
...
---
_id: '1203'
abstract:
- lang: eng
  text: Haemophilus haemolyticus has been recently discovered to have the potential
    to cause invasive disease. It is closely related to nontypeable Haemophilus influenzae
    (NT H. influenzae). NT H. influenzae and H. haemolyticus are often misidentified
    because none of the existing tests targeting the known phenotypes of H. haemolyticus
    are able to specifically identify H. haemolyticus. Through comparative genomic
    analysis of H. haemolyticus and NT H. influenzae, we identified genes unique to
    H. haemolyticus that can be used as targets for the identification of H. haemolyticus.
    A real-time PCR targeting purT (encoding phosphoribosylglycinamide formyltransferase
    2 in the purine synthesis pathway) was developed and evaluated. The lower limit
    of detection was 40 genomes/PCR; the sensitivity and specificity in detecting
    H. haemolyticus were 98.9% and 97%, respectively. To improve the discrimination
    of H. haemolyticus and NT H. influenzae, a testing scheme combining two targets
    (H. haemolyticus purT and H. influenzae hpd, encoding protein D lipoprotein) was
    also evaluated and showed 96.7% sensitivity and 98.2% specificity for the identification
    of H. haemolyticus and 92.8% sensitivity and 100% specificity for the identification
    of H. influenzae, respectively. The dual-target testing scheme can be used for
    the diagnosis and surveillance of infection and disease caused by H. haemolyticus
    and NT H. influenzae.
acknowledgement: We are grateful to ABCs for providing strains and the Bacterial Meningitis
  Laboratory for technical support.
article_processing_charge: No
author:
- first_name: Fang
  full_name: Hu, Fang
  last_name: Hu
- first_name: Lavanya
  full_name: Rishishwar, Lavanya
  last_name: Rishishwar
- first_name: Ambily
  full_name: Sivadas, Ambily
  last_name: Sivadas
- first_name: Gabriel
  full_name: Mitchell, Gabriel
  id: 315BCD80-F248-11E8-B48F-1D18A9856A87
  last_name: Mitchell
- first_name: Jordan
  full_name: King, Jordan
  last_name: King
- first_name: Timothy
  full_name: Murphy, Timothy
  last_name: Murphy
- first_name: Janet
  full_name: Gilsdorf, Janet
  last_name: Gilsdorf
- first_name: Leonard
  full_name: Mayer, Leonard
  last_name: Mayer
- first_name: Xin
  full_name: Wang, Xin
  last_name: Wang
citation:
  ama: Hu F, Rishishwar L, Sivadas A, et al. Comparative genomic analysis of Haemophilus
    haemolyticus and nontypeable Haemophilus influenzae and a new testing scheme for
    their discrimination. <i>Journal of Clinical Microbiology</i>. 2016;54(12):3010-3017.
    doi:<a href="https://doi.org/10.1128/JCM.01511-16">10.1128/JCM.01511-16</a>
  apa: Hu, F., Rishishwar, L., Sivadas, A., Mitchell, G., King, J., Murphy, T., …
    Wang, X. (2016). Comparative genomic analysis of Haemophilus haemolyticus and
    nontypeable Haemophilus influenzae and a new testing scheme for their discrimination.
    <i>Journal of Clinical Microbiology</i>. American Society for Microbiology. <a
    href="https://doi.org/10.1128/JCM.01511-16">https://doi.org/10.1128/JCM.01511-16</a>
  chicago: Hu, Fang, Lavanya Rishishwar, Ambily Sivadas, Gabriel Mitchell, Jordan
    King, Timothy Murphy, Janet Gilsdorf, Leonard Mayer, and Xin Wang. “Comparative
    Genomic Analysis of Haemophilus Haemolyticus and Nontypeable Haemophilus Influenzae
    and a New Testing Scheme for Their Discrimination.” <i>Journal of Clinical Microbiology</i>.
    American Society for Microbiology, 2016. <a href="https://doi.org/10.1128/JCM.01511-16">https://doi.org/10.1128/JCM.01511-16</a>.
  ieee: F. Hu <i>et al.</i>, “Comparative genomic analysis of Haemophilus haemolyticus
    and nontypeable Haemophilus influenzae and a new testing scheme for their discrimination,”
    <i>Journal of Clinical Microbiology</i>, vol. 54, no. 12. American Society for
    Microbiology, pp. 3010–3017, 2016.
  ista: Hu F, Rishishwar L, Sivadas A, Mitchell G, King J, Murphy T, Gilsdorf J, Mayer
    L, Wang X. 2016. Comparative genomic analysis of Haemophilus haemolyticus and
    nontypeable Haemophilus influenzae and a new testing scheme for their discrimination.
    Journal of Clinical Microbiology. 54(12), 3010–3017.
  mla: Hu, Fang, et al. “Comparative Genomic Analysis of Haemophilus Haemolyticus
    and Nontypeable Haemophilus Influenzae and a New Testing Scheme for Their Discrimination.”
    <i>Journal of Clinical Microbiology</i>, vol. 54, no. 12, American Society for
    Microbiology, 2016, pp. 3010–17, doi:<a href="https://doi.org/10.1128/JCM.01511-16">10.1128/JCM.01511-16</a>.
  short: F. Hu, L. Rishishwar, A. Sivadas, G. Mitchell, J. King, T. Murphy, J. Gilsdorf,
    L. Mayer, X. Wang, Journal of Clinical Microbiology 54 (2016) 3010–3017.
date_created: 2018-12-11T11:50:41Z
date_published: 2016-12-01T00:00:00Z
date_updated: 2025-09-22T09:40:28Z
day: '01'
department:
- _id: GaTk
doi: 10.1128/JCM.01511-16
external_id:
  isi:
  - '000389209600026'
fulldoi: https://doi.org/10.1128/JCM.01511-16
intvolume: '        54'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121393/
month: '12'
oa: 1
oa_version: Submitted Version
page: 3010 - 3017
publication: Journal of Clinical Microbiology
publication_status: published
publisher: American Society for Microbiology
publist_id: '6146'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Comparative genomic analysis of Haemophilus haemolyticus and nontypeable Haemophilus
  influenzae and a new testing scheme for their discrimination
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 54
year: '2016'
...
