[{"publication_status":"published","pmid":1,"citation":{"ieee":"D. Feitosa Tomé <i>et al.</i>, “Dynamic and selective engrams emerge with memory consolidation,” <i>Nature Neuroscience</i>, vol. 27. Springer Nature, pp. 561–572, 2024.","apa":"Feitosa Tomé, D., Zhang, Y., Aida, T., Mosto, O., Lu, Y., Chen, M., … Clopath, C. (2024). Dynamic and selective engrams emerge with memory consolidation. <i>Nature Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41593-023-01551-w\">https://doi.org/10.1038/s41593-023-01551-w</a>","ista":"Feitosa Tomé D, Zhang Y, Aida T, Mosto O, Lu Y, Chen M, Sadeh S, Roy DS, Clopath C. 2024. Dynamic and selective engrams emerge with memory consolidation. Nature Neuroscience. 27, 561–572.","mla":"Feitosa Tomé, Douglas, et al. “Dynamic and Selective Engrams Emerge with Memory Consolidation.” <i>Nature Neuroscience</i>, vol. 27, Springer Nature, 2024, pp. 561–72, doi:<a href=\"https://doi.org/10.1038/s41593-023-01551-w\">10.1038/s41593-023-01551-w</a>.","ama":"Feitosa Tomé D, Zhang Y, Aida T, et al. Dynamic and selective engrams emerge with memory consolidation. <i>Nature Neuroscience</i>. 2024;27:561-572. doi:<a href=\"https://doi.org/10.1038/s41593-023-01551-w\">10.1038/s41593-023-01551-w</a>","short":"D. Feitosa Tomé, Y. Zhang, T. Aida, O. Mosto, Y. Lu, M. Chen, S. Sadeh, D.S. Roy, C. Clopath, Nature Neuroscience 27 (2024) 561–572.","chicago":"Feitosa Tomé, Douglas, Ying Zhang, Tomomi Aida, Olivia Mosto, Yifeng Lu, Mandy Chen, Sadra Sadeh, Dheeraj S. Roy, and Claudia Clopath. “Dynamic and Selective Engrams Emerge with Memory Consolidation.” <i>Nature Neuroscience</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41593-023-01551-w\">https://doi.org/10.1038/s41593-023-01551-w</a>."},"acknowledgement":"We thank S. Erisken from Inscopix for helping us establish in vivo one-photon calcium imaging for this work. We thank K. Su at Tsinghua University for assistance with this work. This work was funded by the President’s PhD Scholarship from Imperial College London (D.F.T.), the Wellcome Trust (225412/Z/22/Z) (S.S.), the Biotechnology and Biological Sciences Research Council (BB/N013956/1 and BB/N019008/1) (C.C.), the Wellcome Trust (200790/Z/16/Z) (C.C.), the Simons Foundation (564408) (C.C.) and the Engineering and Physical Sciences Research Council (EP/R035806/1) (CC). The School of Life Sciences and the IDG/McGovern Institute for Brain Research supported Y.Z. The Warren Alpert Distinguished Scholar Award and National Institutes of Health 1K99NS125131-01 supported D.S.R.","oa":1,"fulldoi":"https://doi.org/10.1038/s41593-023-01551-w","intvolume":"        27","type":"journal_article","oa_version":"Published Version","date_created":"2024-01-28T23:01:43Z","file":[{"file_size":15830346,"file_name":"2024_NatureNeuroscience_FeitosaTome.pdf","content_type":"application/pdf","date_created":"2024-07-16T12:15:19Z","date_updated":"2024-07-16T12:15:19Z","relation":"main_file","access_level":"open_access","creator":"dernst","file_id":"17268","checksum":"c509fcad757e4c1c153e857e55c20083","success":1}],"day":"01","year":"2024","corr_author":"1","publication_identifier":{"eissn":["1546-1726"],"issn":["1097-6256"]},"publisher":"Springer Nature","page":"561-572","language":[{"iso":"eng"}],"abstract":[{"text":"Episodic memories are encoded by experience-activated neuronal ensembles that remain necessary and sufficient for recall. However, the temporal evolution of memory engrams after initial encoding is unclear. In this study, we employed computational and experimental approaches to examine how the neural composition and selectivity of engrams change with memory consolidation. Our spiking neural network model yielded testable predictions: memories transition from unselective to selective as neurons drop out of and drop into engrams; inhibitory activity during recall is essential for memory selectivity; and inhibitory synaptic plasticity during memory consolidation is critical for engrams to become selective. Using activity-dependent labeling, longitudinal calcium imaging and a combination of optogenetic and chemogenetic manipulations in mouse dentate gyrus, we conducted contextual fear conditioning experiments that supported our model’s predictions. Our results reveal that memory engrams are dynamic and that changes in engram composition mediated by inhibitory plasticity are crucial for the emergence of memory selectivity.","lang":"eng"}],"isi":1,"author":[{"first_name":"Douglas","last_name":"Feitosa Tomé","full_name":"Feitosa Tomé, Douglas","id":"0eed2d40-3d48-11ec-8d38-f789cc2e40b2"},{"first_name":"Ying","last_name":"Zhang","full_name":"Zhang, Ying"},{"first_name":"Tomomi","last_name":"Aida","full_name":"Aida, Tomomi"},{"full_name":"Mosto, Olivia","last_name":"Mosto","first_name":"Olivia"},{"full_name":"Lu, Yifeng","last_name":"Lu","first_name":"Yifeng"},{"last_name":"Chen","first_name":"Mandy","full_name":"Chen, Mandy"},{"first_name":"Sadra","last_name":"Sadeh","full_name":"Sadeh, Sadra"},{"last_name":"Roy","first_name":"Dheeraj S.","full_name":"Roy, Dheeraj S."},{"last_name":"Clopath","first_name":"Claudia","full_name":"Clopath, Claudia"}],"ddc":["570"],"volume":27,"_id":"14887","scopus_import":"1","external_id":{"isi":["001145442300001"],"pmid":["38243089"]},"file_date_updated":"2024-07-16T12:15:19Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"relation":"research_data","id":"14892","status":"public"}]},"article_processing_charge":"Yes (in subscription journal)","title":"Dynamic and selective engrams emerge with memory consolidation","date_updated":"2025-04-23T07:40:21Z","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"quality_controlled":"1","status":"public","doi":"10.1038/s41593-023-01551-w","publication":"Nature Neuroscience","month":"03","department":[{"_id":"TiVo"}],"article_type":"original","date_published":"2024-03-01T00:00:00Z"},{"publisher":"Society for Neuroscience","language":[{"iso":"eng"}],"article_number":"e0846232024","abstract":[{"text":"Memories are thought to be stored in neural ensembles known as engrams that are specifically reactivated during memory recall. Recent studies have found that memory engrams of two events that happened close in time tend to overlap in the hippocampus and the amygdala, and these overlaps have been shown to support memory linking. It has been hypothesized that engram overlaps arise from the mechanisms that regulate memory allocation itself, involving neural excitability, but the exact process remains unclear. Indeed, most theoretical studies focus on synaptic plasticity and little is known about the role of intrinsic plasticity, which could be mediated by neural excitability and serve as a complementary mechanism for forming memory engrams. Here, we developed a rate-based recurrent neural network that includes both synaptic plasticity and neural excitability. We obtained structural and functional overlap of memory engrams for contexts that are presented close in time, consistent with experimental and computational studies. We then investigated the role of excitability in memory allocation at the network level and unveiled competitive mechanisms driven by inhibition. This work suggests mechanisms underlying the role of intrinsic excitability in memory allocation and linking, and yields predictions regarding the formation and the overlap of memory engrams.","lang":"eng"}],"file":[{"creator":"dernst","file_id":"17095","checksum":"4e19159800db605b802c721e4d4b1ffe","success":1,"relation":"main_file","date_updated":"2024-06-03T06:34:21Z","date_created":"2024-06-03T06:34:21Z","access_level":"open_access","file_size":920354,"content_type":"application/pdf","file_name":"2024_JourNeuroscience_Delamare.pdf"}],"day":"22","year":"2024","publication_identifier":{"eissn":["1529-2401"],"issn":["0270-6474"]},"oa":1,"intvolume":"        44","fulldoi":"https://doi.org/10.1523/JNEUROSCI.0846-23.2024","type":"journal_article","oa_version":"Published Version","date_created":"2024-06-02T22:00:57Z","issue":"21","pmid":1,"publication_status":"published","citation":{"ieee":"G. Delamare, D. Feitosa Tomé, and C. Clopath, “Intrinsic neural excitability biases allocation and overlap of memory engrams,” <i>Journal of Neuroscience</i>, vol. 44, no. 21. Society for Neuroscience, 2024.","apa":"Delamare, G., Feitosa Tomé, D., &#38; Clopath, C. (2024). Intrinsic neural excitability biases allocation and overlap of memory engrams. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.0846-23.2024\">https://doi.org/10.1523/JNEUROSCI.0846-23.2024</a>","ista":"Delamare G, Feitosa Tomé D, Clopath C. 2024. Intrinsic neural excitability biases allocation and overlap of memory engrams. Journal of Neuroscience. 44(21), e0846232024.","ama":"Delamare G, Feitosa Tomé D, Clopath C. Intrinsic neural excitability biases allocation and overlap of memory engrams. <i>Journal of Neuroscience</i>. 2024;44(21). doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.0846-23.2024\">10.1523/JNEUROSCI.0846-23.2024</a>","mla":"Delamare, Geoffroy, et al. “Intrinsic Neural Excitability Biases Allocation and Overlap of Memory Engrams.” <i>Journal of Neuroscience</i>, vol. 44, no. 21, e0846232024, Society for Neuroscience, 2024, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.0846-23.2024\">10.1523/JNEUROSCI.0846-23.2024</a>.","short":"G. Delamare, D. Feitosa Tomé, C. Clopath, Journal of Neuroscience 44 (2024).","chicago":"Delamare, Geoffroy, Douglas Feitosa Tomé, and Claudia Clopath. “Intrinsic Neural Excitability Biases Allocation and Overlap of Memory Engrams.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2024. <a href=\"https://doi.org/10.1523/JNEUROSCI.0846-23.2024\">https://doi.org/10.1523/JNEUROSCI.0846-23.2024</a>."},"acknowledgement":"We thank Sadra Sadeh and Inês Completo Guerreiro for helpful comments on the manuscript, Yosif Zaki and Denise J. Cai for useful feedback and members of the Clopath lab for discussion and support. This work was supported by Biotechnology and Biological Sciences Research Council (BB/N013956/1 awarded to C.C.), Wellcome Trust (200790/Z/16/Z awarded to C.C.), the Simons Foundation (564408 awarded to C.C.), and Engineering and Physical Sciences Research Council (EP/R035806/1 awarded to C.C.).","department":[{"_id":"TiVo"}],"date_published":"2024-05-22T00:00:00Z","article_type":"original","quality_controlled":"1","status":"public","doi":"10.1523/JNEUROSCI.0846-23.2024","publication":"Journal of Neuroscience","month":"05","external_id":{"pmid":["38561228"],"isi":["001249681000008"]},"file_date_updated":"2024-06-03T06:34:21Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","article_processing_charge":"Yes (in subscription journal)","title":"Intrinsic neural excitability biases allocation and overlap of memory engrams","date_updated":"2025-09-08T07:40:58Z","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"isi":1,"author":[{"full_name":"Delamare, Geoffroy","first_name":"Geoffroy","last_name":"Delamare"},{"first_name":"Douglas","last_name":"Feitosa Tomé","full_name":"Feitosa Tomé, Douglas","id":"0eed2d40-3d48-11ec-8d38-f789cc2e40b2"},{"last_name":"Clopath","first_name":"Claudia","full_name":"Clopath, Claudia"}],"ddc":["570"],"volume":44,"_id":"17092","scopus_import":"1"},{"month":"12","doi":"10.5281/ZENODO.10251087","year":"2023","corr_author":"1","day":"02","status":"public","abstract":[{"text":"Code and data necessary to reproduce the simulations and data analyses reported in our manuscript: Tomé, D.F., Zhang, Y., Aida, T., Mosto, O., Lu, Y., Chen, M., Sadeh, S., Roy, D. S., Clopath, C. Dynamic and selective engrams emerge with memory consolidation. 2023.","lang":"eng"}],"department":[{"_id":"TiVo"}],"publisher":"Zenodo","date_published":"2023-12-02T00:00:00Z","_id":"14892","citation":{"short":"D. Feitosa Tomé, (2023).","chicago":"Feitosa Tomé, Douglas. “Douglastome/Dynamic-Engrams: Dynamic and Selective Engrams Emerge with Memory Consolidation.” Zenodo, 2023. <a href=\"https://doi.org/10.5281/ZENODO.10251087\">https://doi.org/10.5281/ZENODO.10251087</a>.","mla":"Feitosa Tomé, Douglas. <i>Douglastome/Dynamic-Engrams: Dynamic and Selective Engrams Emerge with Memory Consolidation</i>. Zenodo, 2023, doi:<a href=\"https://doi.org/10.5281/ZENODO.10251087\">10.5281/ZENODO.10251087</a>.","ama":"Feitosa Tomé D. douglastome/dynamic-engrams: Dynamic and selective engrams emerge with memory consolidation. 2023. doi:<a href=\"https://doi.org/10.5281/ZENODO.10251087\">10.5281/ZENODO.10251087</a>","ieee":"D. Feitosa Tomé, “douglastome/dynamic-engrams: Dynamic and selective engrams emerge with memory consolidation.” Zenodo, 2023.","apa":"Feitosa Tomé, D. (2023). douglastome/dynamic-engrams: Dynamic and selective engrams emerge with memory consolidation. Zenodo. <a href=\"https://doi.org/10.5281/ZENODO.10251087\">https://doi.org/10.5281/ZENODO.10251087</a>","ista":"Feitosa Tomé D. 2023. douglastome/dynamic-engrams: Dynamic and selective engrams emerge with memory consolidation, Zenodo, <a href=\"https://doi.org/10.5281/ZENODO.10251087\">10.5281/ZENODO.10251087</a>."},"main_file_link":[{"url":"https://doi.org/10.5281/zenodo.10251087","open_access":"1"}],"author":[{"full_name":"Feitosa Tomé, Douglas","id":"0eed2d40-3d48-11ec-8d38-f789cc2e40b2","first_name":"Douglas","last_name":"Feitosa Tomé"}],"ddc":["570"],"date_updated":"2025-04-23T07:40:21Z","article_processing_charge":"No","title":"douglastome/dynamic-engrams: Dynamic and selective engrams emerge with memory consolidation","date_created":"2024-01-29T09:06:43Z","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"has_accepted_license":"1","fulldoi":"https://doi.org/10.5281/ZENODO.10251087","oa":1,"oa_version":"None","type":"research_data_reference","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"14887"}]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"}]