---
_id: '14887'
abstract:
- lang: eng
  text: 'Episodic memories are encoded by experience-activated neuronal ensembles
    that remain necessary and sufficient for recall. However, the temporal evolution
    of memory engrams after initial encoding is unclear. In this study, we employed
    computational and experimental approaches to examine how the neural composition
    and selectivity of engrams change with memory consolidation. Our spiking neural
    network model yielded testable predictions: memories transition from unselective
    to selective as neurons drop out of and drop into engrams; inhibitory activity
    during recall is essential for memory selectivity; and inhibitory synaptic plasticity
    during memory consolidation is critical for engrams to become selective. Using
    activity-dependent labeling, longitudinal calcium imaging and a combination of
    optogenetic and chemogenetic manipulations in mouse dentate gyrus, we conducted
    contextual fear conditioning experiments that supported our model’s predictions.
    Our results reveal that memory engrams are dynamic and that changes in engram
    composition mediated by inhibitory plasticity are crucial for the emergence of
    memory selectivity.'
acknowledgement: We thank S. Erisken from Inscopix for helping us establish in vivo
  one-photon calcium imaging for this work. We thank K. Su at Tsinghua University
  for assistance with this work. This work was funded by the President’s PhD Scholarship
  from Imperial College London (D.F.T.), the Wellcome Trust (225412/Z/22/Z) (S.S.),
  the Biotechnology and Biological Sciences Research Council (BB/N013956/1 and BB/N019008/1)
  (C.C.), the Wellcome Trust (200790/Z/16/Z) (C.C.), the Simons Foundation (564408)
  (C.C.) and the Engineering and Physical Sciences Research Council (EP/R035806/1)
  (CC). The School of Life Sciences and the IDG/McGovern Institute for Brain Research
  supported Y.Z. The Warren Alpert Distinguished Scholar Award and National Institutes
  of Health 1K99NS125131-01 supported D.S.R.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Douglas
  full_name: Feitosa Tomé, Douglas
  id: 0eed2d40-3d48-11ec-8d38-f789cc2e40b2
  last_name: Feitosa Tomé
- first_name: Ying
  full_name: Zhang, Ying
  last_name: Zhang
- first_name: Tomomi
  full_name: Aida, Tomomi
  last_name: Aida
- first_name: Olivia
  full_name: Mosto, Olivia
  last_name: Mosto
- first_name: Yifeng
  full_name: Lu, Yifeng
  last_name: Lu
- first_name: Mandy
  full_name: Chen, Mandy
  last_name: Chen
- first_name: Sadra
  full_name: Sadeh, Sadra
  last_name: Sadeh
- first_name: Dheeraj S.
  full_name: Roy, Dheeraj S.
  last_name: Roy
- first_name: Claudia
  full_name: Clopath, Claudia
  last_name: Clopath
citation:
  ama: Feitosa Tomé D, Zhang Y, Aida T, et al. Dynamic and selective engrams emerge
    with memory consolidation. <i>Nature Neuroscience</i>. 2024;27:561-572. doi:<a
    href="https://doi.org/10.1038/s41593-023-01551-w">10.1038/s41593-023-01551-w</a>
  apa: Feitosa Tomé, D., Zhang, Y., Aida, T., Mosto, O., Lu, Y., Chen, M., … Clopath,
    C. (2024). Dynamic and selective engrams emerge with memory consolidation. <i>Nature
    Neuroscience</i>. Springer Nature. <a href="https://doi.org/10.1038/s41593-023-01551-w">https://doi.org/10.1038/s41593-023-01551-w</a>
  chicago: Feitosa Tomé, Douglas, Ying Zhang, Tomomi Aida, Olivia Mosto, Yifeng Lu,
    Mandy Chen, Sadra Sadeh, Dheeraj S. Roy, and Claudia Clopath. “Dynamic and Selective
    Engrams Emerge with Memory Consolidation.” <i>Nature Neuroscience</i>. Springer
    Nature, 2024. <a href="https://doi.org/10.1038/s41593-023-01551-w">https://doi.org/10.1038/s41593-023-01551-w</a>.
  ieee: D. Feitosa Tomé <i>et al.</i>, “Dynamic and selective engrams emerge with
    memory consolidation,” <i>Nature Neuroscience</i>, vol. 27. Springer Nature, pp.
    561–572, 2024.
  ista: Feitosa Tomé D, Zhang Y, Aida T, Mosto O, Lu Y, Chen M, Sadeh S, Roy DS, Clopath
    C. 2024. Dynamic and selective engrams emerge with memory consolidation. Nature
    Neuroscience. 27, 561–572.
  mla: Feitosa Tomé, Douglas, et al. “Dynamic and Selective Engrams Emerge with Memory
    Consolidation.” <i>Nature Neuroscience</i>, vol. 27, Springer Nature, 2024, pp.
    561–72, doi:<a href="https://doi.org/10.1038/s41593-023-01551-w">10.1038/s41593-023-01551-w</a>.
  short: D. Feitosa Tomé, Y. Zhang, T. Aida, O. Mosto, Y. Lu, M. Chen, S. Sadeh, D.S.
    Roy, C. Clopath, Nature Neuroscience 27 (2024) 561–572.
corr_author: '1'
date_created: 2024-01-28T23:01:43Z
date_published: 2024-03-01T00:00:00Z
date_updated: 2025-04-23T07:40:21Z
day: '01'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1038/s41593-023-01551-w
external_id:
  isi:
  - '001145442300001'
  pmid:
  - '38243089'
file:
- access_level: open_access
  checksum: c509fcad757e4c1c153e857e55c20083
  content_type: application/pdf
  creator: dernst
  date_created: 2024-07-16T12:15:19Z
  date_updated: 2024-07-16T12:15:19Z
  file_id: '17268'
  file_name: 2024_NatureNeuroscience_FeitosaTome.pdf
  file_size: 15830346
  relation: main_file
  success: 1
file_date_updated: 2024-07-16T12:15:19Z
fulldoi: https://doi.org/10.1038/s41593-023-01551-w
has_accepted_license: '1'
intvolume: '        27'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
oa: 1
oa_version: Published Version
page: 561-572
pmid: 1
publication: Nature Neuroscience
publication_identifier:
  eissn:
  - 1546-1726
  issn:
  - 1097-6256
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
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  - id: '14892'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Dynamic and selective engrams emerge with memory consolidation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 27
year: '2024'
...
---
_id: '17092'
abstract:
- lang: eng
  text: Memories are thought to be stored in neural ensembles known as engrams that
    are specifically reactivated during memory recall. Recent studies have found that
    memory engrams of two events that happened close in time tend to overlap in the
    hippocampus and the amygdala, and these overlaps have been shown to support memory
    linking. It has been hypothesized that engram overlaps arise from the mechanisms
    that regulate memory allocation itself, involving neural excitability, but the
    exact process remains unclear. Indeed, most theoretical studies focus on synaptic
    plasticity and little is known about the role of intrinsic plasticity, which could
    be mediated by neural excitability and serve as a complementary mechanism for
    forming memory engrams. Here, we developed a rate-based recurrent neural network
    that includes both synaptic plasticity and neural excitability. We obtained structural
    and functional overlap of memory engrams for contexts that are presented close
    in time, consistent with experimental and computational studies. We then investigated
    the role of excitability in memory allocation at the network level and unveiled
    competitive mechanisms driven by inhibition. This work suggests mechanisms underlying
    the role of intrinsic excitability in memory allocation and linking, and yields
    predictions regarding the formation and the overlap of memory engrams.
acknowledgement: We thank Sadra Sadeh and Inês Completo Guerreiro for helpful comments
  on the manuscript, Yosif Zaki and Denise J. Cai for useful feedback and members
  of the Clopath lab for discussion and support. This work was supported by Biotechnology
  and Biological Sciences Research Council (BB/N013956/1 awarded to C.C.), Wellcome
  Trust (200790/Z/16/Z awarded to C.C.), the Simons Foundation (564408 awarded to
  C.C.), and Engineering and Physical Sciences Research Council (EP/R035806/1 awarded
  to C.C.).
article_number: e0846232024
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Geoffroy
  full_name: Delamare, Geoffroy
  last_name: Delamare
- first_name: Douglas
  full_name: Feitosa Tomé, Douglas
  id: 0eed2d40-3d48-11ec-8d38-f789cc2e40b2
  last_name: Feitosa Tomé
- first_name: Claudia
  full_name: Clopath, Claudia
  last_name: Clopath
citation:
  ama: Delamare G, Feitosa Tomé D, Clopath C. Intrinsic neural excitability biases
    allocation and overlap of memory engrams. <i>Journal of Neuroscience</i>. 2024;44(21).
    doi:<a href="https://doi.org/10.1523/JNEUROSCI.0846-23.2024">10.1523/JNEUROSCI.0846-23.2024</a>
  apa: Delamare, G., Feitosa Tomé, D., &#38; Clopath, C. (2024). Intrinsic neural
    excitability biases allocation and overlap of memory engrams. <i>Journal of Neuroscience</i>.
    Society for Neuroscience. <a href="https://doi.org/10.1523/JNEUROSCI.0846-23.2024">https://doi.org/10.1523/JNEUROSCI.0846-23.2024</a>
  chicago: Delamare, Geoffroy, Douglas Feitosa Tomé, and Claudia Clopath. “Intrinsic
    Neural Excitability Biases Allocation and Overlap of Memory Engrams.” <i>Journal
    of Neuroscience</i>. Society for Neuroscience, 2024. <a href="https://doi.org/10.1523/JNEUROSCI.0846-23.2024">https://doi.org/10.1523/JNEUROSCI.0846-23.2024</a>.
  ieee: G. Delamare, D. Feitosa Tomé, and C. Clopath, “Intrinsic neural excitability
    biases allocation and overlap of memory engrams,” <i>Journal of Neuroscience</i>,
    vol. 44, no. 21. Society for Neuroscience, 2024.
  ista: Delamare G, Feitosa Tomé D, Clopath C. 2024. Intrinsic neural excitability
    biases allocation and overlap of memory engrams. Journal of Neuroscience. 44(21),
    e0846232024.
  mla: Delamare, Geoffroy, et al. “Intrinsic Neural Excitability Biases Allocation
    and Overlap of Memory Engrams.” <i>Journal of Neuroscience</i>, vol. 44, no. 21,
    e0846232024, Society for Neuroscience, 2024, doi:<a href="https://doi.org/10.1523/JNEUROSCI.0846-23.2024">10.1523/JNEUROSCI.0846-23.2024</a>.
  short: G. Delamare, D. Feitosa Tomé, C. Clopath, Journal of Neuroscience 44 (2024).
date_created: 2024-06-02T22:00:57Z
date_published: 2024-05-22T00:00:00Z
date_updated: 2025-09-08T07:40:58Z
day: '22'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1523/JNEUROSCI.0846-23.2024
external_id:
  isi:
  - '001249681000008'
  pmid:
  - '38561228'
file:
- access_level: open_access
  checksum: 4e19159800db605b802c721e4d4b1ffe
  content_type: application/pdf
  creator: dernst
  date_created: 2024-06-03T06:34:21Z
  date_updated: 2024-06-03T06:34:21Z
  file_id: '17095'
  file_name: 2024_JourNeuroscience_Delamare.pdf
  file_size: 920354
  relation: main_file
  success: 1
file_date_updated: 2024-06-03T06:34:21Z
fulldoi: https://doi.org/10.1523/JNEUROSCI.0846-23.2024
has_accepted_license: '1'
intvolume: '        44'
isi: 1
issue: '21'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
  eissn:
  - 1529-2401
  issn:
  - 0270-6474
publication_status: published
publisher: Society for Neuroscience
quality_controlled: '1'
scopus_import: '1'
status: public
title: Intrinsic neural excitability biases allocation and overlap of memory engrams
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 44
year: '2024'
...
---
_id: '14892'
abstract:
- lang: eng
  text: 'Code and data necessary to reproduce the simulations and data analyses reported
    in our manuscript: Tomé, D.F., Zhang, Y., Aida, T., Mosto, O., Lu, Y., Chen, M.,
    Sadeh, S., Roy, D. S., Clopath, C. Dynamic and selective engrams emerge with memory
    consolidation. 2023.'
article_processing_charge: No
author:
- first_name: Douglas
  full_name: Feitosa Tomé, Douglas
  id: 0eed2d40-3d48-11ec-8d38-f789cc2e40b2
  last_name: Feitosa Tomé
citation:
  ama: 'Feitosa Tomé D. douglastome/dynamic-engrams: Dynamic and selective engrams
    emerge with memory consolidation. 2023. doi:<a href="https://doi.org/10.5281/ZENODO.10251087">10.5281/ZENODO.10251087</a>'
  apa: 'Feitosa Tomé, D. (2023). douglastome/dynamic-engrams: Dynamic and selective
    engrams emerge with memory consolidation. Zenodo. <a href="https://doi.org/10.5281/ZENODO.10251087">https://doi.org/10.5281/ZENODO.10251087</a>'
  chicago: 'Feitosa Tomé, Douglas. “Douglastome/Dynamic-Engrams: Dynamic and Selective
    Engrams Emerge with Memory Consolidation.” Zenodo, 2023. <a href="https://doi.org/10.5281/ZENODO.10251087">https://doi.org/10.5281/ZENODO.10251087</a>.'
  ieee: 'D. Feitosa Tomé, “douglastome/dynamic-engrams: Dynamic and selective engrams
    emerge with memory consolidation.” Zenodo, 2023.'
  ista: 'Feitosa Tomé D. 2023. douglastome/dynamic-engrams: Dynamic and selective
    engrams emerge with memory consolidation, Zenodo, <a href="https://doi.org/10.5281/ZENODO.10251087">10.5281/ZENODO.10251087</a>.'
  mla: 'Feitosa Tomé, Douglas. <i>Douglastome/Dynamic-Engrams: Dynamic and Selective
    Engrams Emerge with Memory Consolidation</i>. Zenodo, 2023, doi:<a href="https://doi.org/10.5281/ZENODO.10251087">10.5281/ZENODO.10251087</a>.'
  short: D. Feitosa Tomé, (2023).
corr_author: '1'
date_created: 2024-01-29T09:06:43Z
date_published: 2023-12-02T00:00:00Z
date_updated: 2025-04-23T07:40:21Z
day: '02'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.5281/ZENODO.10251087
fulldoi: https://doi.org/10.5281/ZENODO.10251087
has_accepted_license: '1'
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5281/zenodo.10251087
month: '12'
oa: 1
oa_version: None
publisher: Zenodo
related_material:
  record:
  - id: '14887'
    relation: used_in_publication
    status: public
status: public
title: 'douglastome/dynamic-engrams: Dynamic and selective engrams emerge with memory
  consolidation'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...