[{"year":"2025","date_created":"2025-10-26T23:01:34Z","publication_status":"published","article_type":"original","doi":"10.1093/evolut/qpaf143","fulldoi":"https://doi.org/10.1093/evolut/qpaf143","scopus_import":"1","article_processing_charge":"No","pmid":1,"publication":"Evolution","date_published":"2025-10-17T00:00:00Z","intvolume":"        79","quality_controlled":"1","date_updated":"2025-12-01T15:03:54Z","external_id":{"isi":["001547542300001"],"pmid":["40668071"]},"department":[{"_id":"NiBa"}],"project":[{"_id":"9B861AAC-BA93-11EA-9121-9846C619BF3A","name":"NOMIS Fellowship Program"}],"oa_version":"Preprint","abstract":[{"lang":"eng","text":"Genetic drift is potentially an important component of selection for sex, as it is a source of statistical associations between alleles at selected loci. By increasing local drift, population structure may thus amplify the evolutionary advantage of sex. However, most previous models have focused either on haploid populations or on diploid populations without spatial structure. In this article, we use two- and three-locus analytical models and multilocus simulations to explore selection for sex in a diploid population structured according to the island model, in the presence of recurrent deleterious mutations. Our results show that selection generally favors an intermediate rate of sex that decreases as the direct cost of sex increases and increases moderately as the degree of population structure increases. Selection for sex is generated by multiple effects involving genetic associations within and between loci. When selection occurs at many loci, it is generally dominated by interference effects involving deleterious alleles at different loci, captured by our three-locus model. In our multilocus simulations, we observed an irreversible spread of asexual mutants under strong costs of sex, and when deleterious mutations are partially recessive. However, population structure may prevent this spread of asexual mutants when dispersal rates are sufficiently small."}],"_id":"20531","status":"public","isi":1,"month":"10","day":"17","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Deleterious mutations and selection for sex in spatially structured, diploid populations","OA_place":"repository","OA_type":"green","acknowledgement":"L.F. is funded by the NOMIS-ISTA Fellowship Program. We thank Colin Olito and two anonymous reviewers for helpful comments, and the bioinformatics and computing services at Roscoff’s Biological Station (Abims platform) and at Institute of Science and Technology Austria for computing time.","publication_identifier":{"eissn":["1558-5646"]},"volume":79,"language":[{"iso":"eng"}],"oa":1,"page":"2167-2180","publisher":"Oxford University Press","citation":{"ista":"Fouqueau L, Roze D. 2025. Deleterious mutations and selection for sex in spatially structured, diploid populations. Evolution. 79(10), 2167–2180.","mla":"Fouqueau, Louise, and Denis Roze. “Deleterious Mutations and Selection for Sex in Spatially Structured, Diploid Populations.” <i>Evolution</i>, vol. 79, no. 10, Oxford University Press, 2025, pp. 2167–80, doi:<a href=\"https://doi.org/10.1093/evolut/qpaf143\">10.1093/evolut/qpaf143</a>.","apa":"Fouqueau, L., &#38; Roze, D. (2025). Deleterious mutations and selection for sex in spatially structured, diploid populations. <i>Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/evolut/qpaf143\">https://doi.org/10.1093/evolut/qpaf143</a>","chicago":"Fouqueau, Louise, and Denis Roze. “Deleterious Mutations and Selection for Sex in Spatially Structured, Diploid Populations.” <i>Evolution</i>. Oxford University Press, 2025. <a href=\"https://doi.org/10.1093/evolut/qpaf143\">https://doi.org/10.1093/evolut/qpaf143</a>.","ieee":"L. Fouqueau and D. Roze, “Deleterious mutations and selection for sex in spatially structured, diploid populations,” <i>Evolution</i>, vol. 79, no. 10. Oxford University Press, pp. 2167–2180, 2025.","ama":"Fouqueau L, Roze D. Deleterious mutations and selection for sex in spatially structured, diploid populations. <i>Evolution</i>. 2025;79(10):2167-2180. doi:<a href=\"https://doi.org/10.1093/evolut/qpaf143\">10.1093/evolut/qpaf143</a>","short":"L. Fouqueau, D. Roze, Evolution 79 (2025) 2167–2180."},"author":[{"last_name":"Fouqueau","id":"1676e173-8143-11ed-8927-fe165216a93f","orcid":"0000-0003-0371-9339","full_name":"Fouqueau, Louise","first_name":"Louise"},{"last_name":"Roze","first_name":"Denis","full_name":"Roze, Denis"}],"issue":"10","type":"journal_article","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2025.01.22.634382"}]},{"author":[{"id":"1676e173-8143-11ed-8927-fe165216a93f","orcid":"0000-0003-0371-9339","full_name":"Fouqueau, Louise","first_name":"Louise","last_name":"Fouqueau"},{"full_name":"Reynes, L","first_name":"L","last_name":"Reynes"},{"last_name":"Tempera","first_name":"F","full_name":"Tempera, F"},{"full_name":"Bajjouk, T","first_name":"T","last_name":"Bajjouk"},{"first_name":"A","full_name":"Blanfuné, A","last_name":"Blanfuné"},{"last_name":"Chevalier","full_name":"Chevalier, C","first_name":"C"},{"last_name":"Laurans","full_name":"Laurans, M","first_name":"M"},{"full_name":"Mauger, S","first_name":"S","last_name":"Mauger"},{"last_name":"Sourisseau","full_name":"Sourisseau, M","first_name":"M"},{"last_name":"Assis","full_name":"Assis, J","first_name":"J"},{"last_name":"Lévêque","first_name":"L","full_name":"Lévêque, L"},{"full_name":"Valero, M","first_name":"M","last_name":"Valero"}],"citation":{"apa":"Fouqueau, L., Reynes, L., Tempera, F., Bajjouk, T., Blanfuné, A., Chevalier, C., … Valero, M. (2024). Seascape genetic study on Laminaria digitata underscores the critical role of sampling schemes. <i>Marine Ecology Progress Series</i>. Inter-Research Science Center. <a href=\"https://doi.org/10.3354/meps14640\">https://doi.org/10.3354/meps14640</a>","mla":"Fouqueau, Louise, et al. “Seascape Genetic Study on Laminaria Digitata Underscores the Critical Role of Sampling Schemes.” <i>Marine Ecology Progress Series</i>, vol. 740, Inter-Research Science Center, 2024, pp. 23–42, doi:<a href=\"https://doi.org/10.3354/meps14640\">10.3354/meps14640</a>.","ista":"Fouqueau L, Reynes L, Tempera F, Bajjouk T, Blanfuné A, Chevalier C, Laurans M, Mauger S, Sourisseau M, Assis J, Lévêque L, Valero M. 2024. Seascape genetic study on Laminaria digitata underscores the critical role of sampling schemes. Marine Ecology Progress Series. 740, 23–42.","chicago":"Fouqueau, Louise, L Reynes, F Tempera, T Bajjouk, A Blanfuné, C Chevalier, M Laurans, et al. “Seascape Genetic Study on Laminaria Digitata Underscores the Critical Role of Sampling Schemes.” <i>Marine Ecology Progress Series</i>. Inter-Research Science Center, 2024. <a href=\"https://doi.org/10.3354/meps14640\">https://doi.org/10.3354/meps14640</a>.","ieee":"L. Fouqueau <i>et al.</i>, “Seascape genetic study on Laminaria digitata underscores the critical role of sampling schemes,” <i>Marine Ecology Progress Series</i>, vol. 740. Inter-Research Science Center, pp. 23–42, 2024.","ama":"Fouqueau L, Reynes L, Tempera F, et al. Seascape genetic study on Laminaria digitata underscores the critical role of sampling schemes. <i>Marine Ecology Progress Series</i>. 2024;740:23-42. doi:<a href=\"https://doi.org/10.3354/meps14640\">10.3354/meps14640</a>","short":"L. Fouqueau, L. Reynes, F. Tempera, T. Bajjouk, A. Blanfuné, C. Chevalier, M. Laurans, S. Mauger, M. Sourisseau, J. Assis, L. Lévêque, M. Valero, Marine Ecology Progress Series 740 (2024) 23–42."},"main_file_link":[{"url":"https://inria.hal.science/hal-04624490/","open_access":"1"}],"type":"journal_article","volume":740,"publication_identifier":{"issn":["0171-8630"],"eissn":["1616-1599"]},"publisher":"Inter-Research Science Center","page":"23-42","language":[{"iso":"eng"}],"oa":1,"_id":"18944","abstract":[{"lang":"eng","text":"Understanding connectivity patterns exhibited by endangered species living in fragmented habitats is fundamental to improving management and conservation actions. Such improvements can be particularly pressing at the trailing edges of these habitats, where populations are facing the greatest challenges from climate change, and appear even more crucial if the species is commercially harvested. Seascape genetics have been increasingly used to meet these needs. In this study, we examined connectivity patterns among 32 populations of the oarweed kelp <jats:italic>Lam</jats:italic><jats:italic>inaria digitata</jats:italic> located at the species’ southern range limit. The distance (or sampling gap) between neighboring populations ranged from a few km to a few 100s of km. By genotyping 11 microsatellite markers, we aimed to (1) refine analyses of population structure; (2) test whether on-shelf islands are genetically more differentiated than mainland populations; (3) evaluate the relative importance of various abiotic conditions in shaping the genetic structure; and (4) evaluate if the relative importance of each environmental factor varied according to sampling schemes. Our analyses revealed a positive relationship between connectivity links and genetic diversity: populations with high levels of connectivity were genetically enriched while isolated populations showed signs of genetic erosion. The genetically impoverished populations corresponded to the southernmost populations as well as populations along the northern coast of Brittany (Locquirec, Saint-Malo Bay) and the northernmost population in Pas-de-Calais. By performing distance-based redundancy analysis on various sampling schemes, geographic distance appeared as the dominant factor influencing connectivity between populations separated by great distances, while hydrodynamic processes were the main factor when analyzing at a final spatial resolution."}],"oa_version":"Submitted Version","department":[{"_id":"NiBa"}],"OA_type":"green","OA_place":"repository","title":"Seascape genetic study on Laminaria digitata underscores the critical role of sampling schemes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","corr_author":"1","day":"25","month":"07","status":"public","article_processing_charge":"No","scopus_import":"1","fulldoi":"https://doi.org/10.3354/meps14640","doi":"10.3354/meps14640","article_type":"original","publication_status":"published","date_created":"2025-01-29T09:09:10Z","year":"2024","date_updated":"2025-01-29T09:12:34Z","quality_controlled":"1","intvolume":"       740","date_published":"2024-07-25T00:00:00Z","publication":"Marine Ecology Progress Series"},{"_id":"17207","oa_version":"Published Version","project":[{"name":"Causes and consequences of population fragmentation","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8","grant_number":"P32896"},{"_id":"9B861AAC-BA93-11EA-9121-9846C619BF3A","name":"NOMIS Fellowship Program"}],"department":[{"_id":"NiBa"}],"external_id":{"isi":["001258359900001"],"pmid":["38941551"]},"title":"Eco-evolutionary dynamics in changing environments: Integrating theory with data","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"28","month":"06","isi":1,"status":"public","article_processing_charge":"No","scopus_import":"1","fulldoi":"https://doi.org/10.1093/jeb/voae067","doi":"10.1093/jeb/voae067","article_type":"letter_note","publication_status":"published","date_created":"2024-07-07T22:01:04Z","year":"2024","quality_controlled":"1","date_updated":"2026-06-18T17:53:35Z","intvolume":"        37","date_published":"2024-06-28T00:00:00Z","publication":"Journal of evolutionary biology","pmid":1,"author":[{"last_name":"Fouqueau","full_name":"Fouqueau, Louise","orcid":"0000-0003-0371-9339","id":"1676e173-8143-11ed-8927-fe165216a93f","first_name":"Louise"},{"last_name":"Polechova","orcid":"0000-0003-0951-3112","full_name":"Polechova, Jitka","id":"3BBFB084-F248-11E8-B48F-1D18A9856A87","first_name":"Jitka"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"citation":{"ista":"Fouqueau L, Polechova J. 2024. Eco-evolutionary dynamics in changing environments: Integrating theory with data. Journal of evolutionary biology. 37(6), 579–587.","mla":"Fouqueau, Louise, and Jitka Polechova. “Eco-Evolutionary Dynamics in Changing Environments: Integrating Theory with Data.” <i>Journal of Evolutionary Biology</i>, vol. 37, no. 6, Oxford University Press, 2024, pp. 579–87, doi:<a href=\"https://doi.org/10.1093/jeb/voae067\">10.1093/jeb/voae067</a>.","apa":"Fouqueau, L., &#38; Polechova, J. (2024). Eco-evolutionary dynamics in changing environments: Integrating theory with data. <i>Journal of Evolutionary Biology</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/jeb/voae067\">https://doi.org/10.1093/jeb/voae067</a>","chicago":"Fouqueau, Louise, and Jitka Polechova. “Eco-Evolutionary Dynamics in Changing Environments: Integrating Theory with Data.” <i>Journal of Evolutionary Biology</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/jeb/voae067\">https://doi.org/10.1093/jeb/voae067</a>.","ama":"Fouqueau L, Polechova J. Eco-evolutionary dynamics in changing environments: Integrating theory with data. <i>Journal of evolutionary biology</i>. 2024;37(6):579-587. doi:<a href=\"https://doi.org/10.1093/jeb/voae067\">10.1093/jeb/voae067</a>","ieee":"L. Fouqueau and J. Polechova, “Eco-evolutionary dynamics in changing environments: Integrating theory with data,” <i>Journal of evolutionary biology</i>, vol. 37, no. 6. Oxford University Press, pp. 579–587, 2024.","short":"L. Fouqueau, J. Polechova, Journal of Evolutionary Biology 37 (2024) 579–587."},"license":"https://creativecommons.org/licenses/by/4.0/","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1093/jeb/voae067"}],"issue":"6","type":"journal_article","volume":37,"publication_identifier":{"eissn":["1420-9101"]},"acknowledgement":"This research was funded by the Austrian Science Fund (FWF), project doi: 10.55776/P32896, Institutional Identifier: 501100002428, grant number: P32896 and L.F. acknowledges the support of the NOMIS-ISTA Fellowship Program.\r\nWe would like to thank Nick Barton, Roger Butlin, Stuart Baird, Patrik Nosil, and Jason Sexton for their insightful comments on the earlier drafts, and to John Carchrae for his valuable contribution in refining phrasing and enhancing clarity. For open access purposes, the author has applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission.","ddc":["570"],"publisher":"Oxford University Press","page":"579-587","oa":1,"language":[{"iso":"eng"}]},{"title":"Temporal genomics help in deciphering neutral and adaptive patterns in the contemporary evolution of kelp populations","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"status":"public","relation":"research_data","id":"22867"}]},"day":"01","month":"06","status":"public","abstract":[{"lang":"eng","text":"The impact of climate change on populations will be contingent upon their contemporary adaptive evolution. In this study, we investigated the contemporary evolution of 4 populations of the cold-water kelp Laminaria digitata by analyzing their spatial and temporal genomic variations using ddRAD-sequencing. These populations were sampled from the center to the southern margin of its north-eastern Atlantic distribution at 2 time points, spanning at least 2 generations. Through genome scans for local adaptation at a single time point, we identified candidate loci that showed clinal variation correlated with changes in sea surface temperature (SST) along latitudinal gradients. This finding suggests that SST may drive the adaptive response of these kelp populations, although factors such as species’ demographic history should also be considered. Additionally, we performed a simulation approach to distinguish the effect of selection from genetic drift in allele frequency changes over time. This enabled the detection of loci in the southernmost population that exhibited temporal differentiation beyond what would be expected from genetic drift alone: these are candidate loci which could have evolved under selection over time. In contrast, we did not detect any outlier locus based on temporal differentiation in the population from the North Sea, which also displayed low and decreasing levels of genetic diversity. The diverse evolutionary scenarios observed among populations can be attributed to variations in the prevalence of selection relative to genetic drift across different environments. Therefore, our study highlights the potential of temporal genomics to offer valuable insights into the contemporary evolution of marine foundation species facing climate change."}],"_id":"17237","oa_version":"Preprint","department":[{"_id":"NiBa"}],"external_id":{"arxiv":["2404.14003"],"pmid":["38629140"]},"quality_controlled":"1","date_updated":"2026-09-09T09:33:37Z","intvolume":"        37","date_published":"2024-06-01T00:00:00Z","publication":"Journal of Evolutionary Biology","pmid":1,"article_processing_charge":"No","scopus_import":"1","fulldoi":"https://doi.org/10.1093/jeb/voae048","doi":"10.1093/jeb/voae048","date_created":"2024-07-14T22:01:12Z","article_type":"original","publication_status":"published","year":"2024","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2404.14003","open_access":"1"}],"issue":"6","type":"journal_article","author":[{"full_name":"Reynes, Lauric","first_name":"Lauric","last_name":"Reynes"},{"last_name":"Fouqueau","full_name":"Fouqueau, Louise","orcid":"0000-0003-0371-9339","id":"1676e173-8143-11ed-8927-fe165216a93f","first_name":"Louise"},{"last_name":"Aurelle","first_name":"Didier","full_name":"Aurelle, Didier"},{"first_name":"Stephane","full_name":"Mauger, Stephane","last_name":"Mauger"},{"last_name":"Destombe","first_name":"Christophe","full_name":"Destombe, Christophe"},{"full_name":"Valero, Myriam","first_name":"Myriam","last_name":"Valero"}],"citation":{"chicago":"Reynes, Lauric, Louise Fouqueau, Didier Aurelle, Stephane Mauger, Christophe Destombe, and Myriam Valero. “Temporal Genomics Help in Deciphering Neutral and Adaptive Patterns in the Contemporary Evolution of Kelp Populations.” <i>Journal of Evolutionary Biology</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/jeb/voae048\">https://doi.org/10.1093/jeb/voae048</a>.","apa":"Reynes, L., Fouqueau, L., Aurelle, D., Mauger, S., Destombe, C., &#38; Valero, M. (2024). Temporal genomics help in deciphering neutral and adaptive patterns in the contemporary evolution of kelp populations. <i>Journal of Evolutionary Biology</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/jeb/voae048\">https://doi.org/10.1093/jeb/voae048</a>","mla":"Reynes, Lauric, et al. “Temporal Genomics Help in Deciphering Neutral and Adaptive Patterns in the Contemporary Evolution of Kelp Populations.” <i>Journal of Evolutionary Biology</i>, vol. 37, no. 6, Oxford University Press, 2024, pp. 677–92, doi:<a href=\"https://doi.org/10.1093/jeb/voae048\">10.1093/jeb/voae048</a>.","ista":"Reynes L, Fouqueau L, Aurelle D, Mauger S, Destombe C, Valero M. 2024. Temporal genomics help in deciphering neutral and adaptive patterns in the contemporary evolution of kelp populations. Journal of Evolutionary Biology. 37(6), 677–692.","short":"L. Reynes, L. Fouqueau, D. Aurelle, S. Mauger, C. Destombe, M. Valero, Journal of Evolutionary Biology 37 (2024) 677–692.","ieee":"L. Reynes, L. Fouqueau, D. Aurelle, S. Mauger, C. Destombe, and M. Valero, “Temporal genomics help in deciphering neutral and adaptive patterns in the contemporary evolution of kelp populations,” <i>Journal of Evolutionary Biology</i>, vol. 37, no. 6. Oxford University Press, pp. 677–692, 2024.","ama":"Reynes L, Fouqueau L, Aurelle D, Mauger S, Destombe C, Valero M. Temporal genomics help in deciphering neutral and adaptive patterns in the contemporary evolution of kelp populations. <i>Journal of Evolutionary Biology</i>. 2024;37(6):677-692. doi:<a href=\"https://doi.org/10.1093/jeb/voae048\">10.1093/jeb/voae048</a>"},"publisher":"Oxford University Press","page":"677-692","arxiv":1,"language":[{"iso":"eng"}],"oa":1,"volume":37,"publication_identifier":{"issn":["1010-061X"],"eissn":["1420-9101"]},"acknowledgement":"This work was funded by the EU project MARFOR Biodiversa/004/2015. L.F. was additionally funded by the Region Bretagne (ARED 2017 REEALG) and the NOMIS Foundation. The project leading to this publication has received funding from the EC2CO (CNRS) fund and from the European FEDER Fund under project 1166-39417.\r\nThis work is especially dedicated to the memory of Gernot Glöckner who contributed to the sequencing of Laminaria digitata genome and passed away in very recent time. The authors thank the ABiMS platform of the Roscoff biological station (http://abims.sb-roscoff.fr) for providing the HPC resources that contributed to the search results reported in this document. We also acknowledge the staff of the “Cluster de calcul intensif HPC” Platform of the OSU Institut Pythéas (Aix-Marseille Université, INSU-CNRS) for providing the computing facilities."}]