[{"publication_status":"published","day":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"19076","quality_controlled":"1","doi":"10.1038/s41593-025-01874-w","publisher":"Springer Nature","oa_version":"Published Version","intvolume":"        28","article_number":"7278","pmid":1,"date_created":"2025-02-23T23:01:58Z","date_updated":"2026-06-18T18:12:08Z","related_material":{"link":[{"description":"News on ISTA Website","url":"https://ista.ac.at/en/news/high-tech-video-optimization-in-our-brain/","relation":"press_release"}],"record":[{"relation":"research_data","id":"18579","status":"public"}]},"project":[{"name":"Circuits of Visual Attention","_id":"2634E9D2-B435-11E9-9278-68D0E5697425","grant_number":"756502","call_identifier":"H2020"},{"grant_number":"101086580","_id":"bdaf81a8-d553-11ed-ba76-c95961984540","name":"Action Selection in the Midbrain: Neuromodulation of Visuomotor Senses"},{"grant_number":"ALTF 1098-2017","_id":"264FEA02-B435-11E9-9278-68D0E5697425","name":"Connecting sensory with motor processing in the superior colliculus"},{"grant_number":"LT000256","name":"Neuronal networks of salience and spatial detection in the murine superior colliculus","_id":"266D407A-B435-11E9-9278-68D0E5697425"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41593-025-01874-w"}],"scopus_import":"1","has_accepted_license":"1","abstract":[{"text":"For accurate perception and motor control, an animal must distinguish between sensory experiences elicited by external stimuli and those elicited by its own actions. The diversity of behaviors and their complex influences on the senses make this distinction challenging. Here, we uncover an action–cue hub that coordinates motor commands with visual processing in the brain’s first visual relay. We show that the ventral lateral geniculate nucleus (vLGN) acts as a corollary discharge center, integrating visual translational optic flow signals with motor copies from saccades, locomotion and pupil dynamics. The vLGN relays these signals to correct action-specific visual distortions and to refine perception, as shown for the superior colliculus and in a depth-estimation task. Simultaneously, brain-wide vLGN projections drive corrective actions necessary for accurate visuomotor control. Our results reveal an extended corollary discharge architecture that refines early visual transformations and coordinates actions via a distributed hub-and-spoke network to enable visual perception during action.","lang":"eng"}],"year":"2025","article_processing_charge":"Yes (via OA deal)","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"publication_identifier":{"eissn":["1546-1726"],"issn":["1097-6256"]},"isi":1,"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"PreCl"},{"_id":"LifeSc"},{"_id":"Bio"}],"article_type":"original","department":[{"_id":"MaJö"},{"_id":"PreCl"}],"oa":1,"publication":"Nature Neuroscience","date_published":"2025-03-01T00:00:00Z","external_id":{"isi":["001416866800001"],"pmid":["39930095"]},"language":[{"iso":"eng"}],"volume":28,"title":"A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics","ddc":["570"],"OA_place":"publisher","type":"journal_article","acknowledgement":"We thank Y. Ben-Simon for generously making viral vectors for retrograde tracing available, as well as J. Watson and F. Marr for reagents. We also thank R. Shigemoto, W. Młynarski and members of the Neuroethology group for their comments on the manuscript and L. Burnett for her schematic drawings. This research was supported by the Scientific Service Units of ISTA through resources provided by Scientific Computing, the Preclinical Facility, the Lab Support Facility and the Imaging and Optics Facility, in particular F. Lange, M. Schunn and T. Asenov. This work was supported by European Research Council Starting Grant no. 756502 (M.J.) and European Research Council Consolidator Grant no. 101086580 (M.J.); and EMBO ALTF grant no. 1098-2017 (A.S.) and Human Frontiers Science Program grant no. LT000256/2018-L (A.S.). Open access funding provided by Institute of Science and Technology (IST Austria).","status":"public","author":[{"full_name":"Vega Zuniga, Tomas A","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87","last_name":"Vega Zuniga","first_name":"Tomas A"},{"full_name":"Sumser, Anton L","orcid":"0000-0002-4792-1881","id":"3320A096-F248-11E8-B48F-1D18A9856A87","first_name":"Anton L","last_name":"Sumser"},{"full_name":"Symonova, Olga","orcid":"0000-0003-2012-9947","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87","last_name":"Symonova","first_name":"Olga"},{"orcid":"0000-0002-3509-1948","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","full_name":"Koppensteiner, Peter","first_name":"Peter","last_name":"Koppensteiner"},{"id":"A2EF226A-AF19-11E9-924C-0525E6697425","full_name":"Schmidt, Florian","last_name":"Schmidt","first_name":"Florian"},{"full_name":"Jösch, Maximilian A","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3937-1330","first_name":"Maximilian A","last_name":"Jösch"}],"corr_author":"1","OA_type":"hybrid","month":"03","citation":{"ama":"Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. <i>Nature Neuroscience</i>. 2025;28. doi:<a href=\"https://doi.org/10.1038/s41593-025-01874-w\">10.1038/s41593-025-01874-w</a>","chicago":"Vega Zuniga, Tomas A, Anton L Sumser, Olga Symonova, Peter Koppensteiner, Florian Schmidt, and Maximilian A Jösch. “A Thalamic Hub-and-Spoke Network Enables Visual Perception during Action by Coordinating Visuomotor Dynamics.” <i>Nature Neuroscience</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41593-025-01874-w\">https://doi.org/10.1038/s41593-025-01874-w</a>.","short":"T.A. Vega Zuniga, A.L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt, M.A. Jösch, Nature Neuroscience 28 (2025).","mla":"Vega Zuniga, Tomas A., et al. “A Thalamic Hub-and-Spoke Network Enables Visual Perception during Action by Coordinating Visuomotor Dynamics.” <i>Nature Neuroscience</i>, vol. 28, 7278, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41593-025-01874-w\">10.1038/s41593-025-01874-w</a>.","ieee":"T. A. Vega Zuniga, A. L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt, and M. A. Jösch, “A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics,” <i>Nature Neuroscience</i>, vol. 28. Springer Nature, 2025.","apa":"Vega Zuniga, T. A., Sumser, A. L., Symonova, O., Koppensteiner, P., Schmidt, F., &#38; Jösch, M. A. (2025). A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. <i>Nature Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41593-025-01874-w\">https://doi.org/10.1038/s41593-025-01874-w</a>","ista":"Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. 2025. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. Nature Neuroscience. 28, 7278."},"ec_funded":1},{"related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"17142"}]},"has_accepted_license":"1","file_date_updated":"2024-05-16T09:08:20Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","_id":"15385","doi":"10.15479/AT:ISTA:15385","publisher":"Institute of Science and Technology Austria","day":"15","date_created":"2024-05-13T15:04:04Z","date_updated":"2025-09-08T07:57:11Z","oa_version":"Published Version","acknowledgement":"We thank Armel Nicolas, Bella Bruszel and Ewelina Dutkiewicz from the ISTA Mass Spectrometry Service (Lab Services Facilities) for all Proteomics work, including samples preparation, LC/MS data acquisition, searches and data evaluation. We thank Prof. Peter Jonas for his suggestion on the involvement of potassium channels and members of the Neuroethology group for their comments on the manuscript. Katalin Szigeti and Julie Murmann for experimental help. This research was supported by the Scientific Service Units of ISTA through resources provided by the Lab Support Facility, the Imaging and Optics Facility, the Machine Shop Unit and the Preclinical Facility, especially Freyja Langer and Michael Schunn. ","status":"public","author":[{"orcid":"0000-0002-8937-410X","id":"3B717F68-F248-11E8-B48F-1D18A9856A87","full_name":"Burnett, Laura","last_name":"Burnett","first_name":"Laura"},{"full_name":"Koppensteiner, Peter","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3509-1948","last_name":"Koppensteiner","first_name":"Peter"},{"orcid":"0000-0003-2012-9947","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87","full_name":"Symonova, Olga","last_name":"Symonova","first_name":"Olga"},{"full_name":"Masson, Tomas","id":"93ac43e8-8599-11eb-9b86-f6efb0a4c207","orcid":"0000-0002-2634-6283","last_name":"Masson","first_name":"Tomas"},{"last_name":"Vega Zuniga","first_name":"Tomas A","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87","full_name":"Vega Zuniga, Tomas A"},{"full_name":"Contreras, Ximena","id":"475990FE-F248-11E8-B48F-1D18A9856A87","last_name":"Contreras","first_name":"Ximena"},{"last_name":"Rülicke","first_name":"Thomas","full_name":"Rülicke, Thomas"},{"first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","first_name":"Gaia"},{"full_name":"Jösch, Maximilian A","orcid":"0000-0002-3937-1330","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","last_name":"Jösch","first_name":"Maximilian A"}],"title":"Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice","ddc":["570"],"type":"research_data","keyword":["ASD","periaqueductal gray","perception","behavior","potassium channels"],"month":"05","license":"https://creativecommons.org/licenses/by-nc/4.0/","citation":{"apa":"Burnett, L., Koppensteiner, P., Symonova, O., Masson, T., Vega Zuniga, T. A., Contreras, X., … Jösch, M. A. (2024). Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:15385\">https://doi.org/10.15479/AT:ISTA:15385</a>","chicago":"Burnett, Laura, Peter Koppensteiner, Olga Symonova, Tomas Masson, Tomas A Vega Zuniga, Ximena Contreras, Thomas Rülicke, Ryuichi Shigemoto, Gaia Novarino, and Maximilian A Jösch. “Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:15385\">https://doi.org/10.15479/AT:ISTA:15385</a>.","short":"L. Burnett, P. Koppensteiner, O. Symonova, T. Masson, T.A. Vega Zuniga, X. Contreras, T. Rülicke, R. Shigemoto, G. Novarino, M.A. Jösch, (2024).","mla":"Burnett, Laura, et al. <i>Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:15385\">10.15479/AT:ISTA:15385</a>.","ieee":"L. Burnett <i>et al.</i>, “Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice.” Institute of Science and Technology Austria, 2024.","ama":"Burnett L, Koppensteiner P, Symonova O, et al. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:15385\">10.15479/AT:ISTA:15385</a>","ista":"Burnett L, Koppensteiner P, Symonova O, Masson T, Vega Zuniga TA, Contreras X, Rülicke T, Shigemoto R, Novarino G, Jösch MA. 2024. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:15385\">10.15479/AT:ISTA:15385</a>."},"corr_author":"1","file":[{"creator":"mjoesch","date_updated":"2024-05-15T06:09:17Z","success":1,"date_created":"2024-05-15T06:09:17Z","checksum":"9205eb0876f0f08552dbad80d6884b4b","file_id":"15396","relation":"main_file","content_type":"application/zip","file_name":"PatchClamp.zip","file_size":"1149617663","access_level":"open_access"},{"date_created":"2024-05-15T06:09:12Z","creator":"mjoesch","date_updated":"2024-05-15T06:09:12Z","success":1,"content_type":"application/zip","relation":"main_file","file_name":"SiliconProbe.zip","file_id":"15397","file_size":"564903112","access_level":"open_access"},{"date_created":"2024-05-15T06:09:14Z","checksum":"49a807bbab06b5fada38f532e2176e2e","date_updated":"2024-05-15T06:09:14Z","creator":"mjoesch","success":1,"relation":"main_file","content_type":"application/zip","file_name":"WesternBlot.zip","file_id":"15398","file_size":"11685703","access_level":"open_access"},{"content_type":"application/zip","relation":"main_file","file_name":"Behaviour.zip","file_id":"15399","date_created":"2024-05-15T06:09:38Z","checksum":"beeeeaa43770090f3b291209ed6b0623","date_updated":"2024-05-15T06:09:38Z","creator":"mjoesch","success":1,"access_level":"open_access","file_size":"1335626779"},{"file_id":"15400","file_name":"Readme_Data.txt","content_type":"text/plain","relation":"main_file","success":1,"creator":"mjoesch","date_updated":"2024-05-16T09:08:20Z","date_created":"2024-05-16T09:08:20Z","checksum":"8862ad7719388304d1d19f8e7db8bb00","access_level":"open_access","file_size":18841}],"tmp":{"image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"acknowledged_ssus":[{"_id":"PreCl"},{"_id":"M-Shop"},{"_id":"LifeSc"},{"_id":"Bio"}],"abstract":[{"lang":"eng","text":"Relevant information about the data can be found in the 'Readme_Data.txt' file. \r\nA previous version of the publication can be found on BioRxiv: https://www.biorxiv.org/content/10.1101/2022.10.11.511691v4\r\nand published in Plos Biology (2024)"}],"year":"2024","article_processing_charge":"No","department":[{"_id":"MaJö"},{"_id":"PreCl"},{"_id":"SiHi"},{"_id":"RySh"},{"_id":"GaNo"}],"oa":1,"date_published":"2024-05-15T00:00:00Z"},{"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11090467"}],"issue":"5","scopus_import":"1","oa_version":"Submitted Version","intvolume":"       532","article_number":"e25620","pmid":1,"date_created":"2024-05-19T22:01:12Z","date_updated":"2025-09-08T07:29:27Z","publication_status":"published","day":"01","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"15404","quality_controlled":"1","doi":"10.1002/cne.25620","publisher":"Wiley","OA_type":"green","month":"05","citation":{"ista":"Reiner A, Medina L, Abellan A, Deng Y, Toledo CAB, Luksch H, Vega Zuniga TA, Riley NB, Hodos W, Karten HJ. 2024. Neurochemistry and circuit organization of the lateral spiriform nucleus of birds: A uniquely nonmammalian direct pathway component of the basal ganglia. Journal of Comparative Neurology. 532(5), e25620.","short":"A. Reiner, L. Medina, A. Abellan, Y. Deng, C.A.B. Toledo, H. Luksch, T.A. Vega Zuniga, N.B. Riley, W. Hodos, H.J. Karten, Journal of Comparative Neurology 532 (2024).","ieee":"A. Reiner <i>et al.</i>, “Neurochemistry and circuit organization of the lateral spiriform nucleus of birds: A uniquely nonmammalian direct pathway component of the basal ganglia,” <i>Journal of Comparative Neurology</i>, vol. 532, no. 5. Wiley, 2024.","mla":"Reiner, Anton, et al. “Neurochemistry and Circuit Organization of the Lateral Spiriform Nucleus of Birds: A Uniquely Nonmammalian Direct Pathway Component of the Basal Ganglia.” <i>Journal of Comparative Neurology</i>, vol. 532, no. 5, e25620, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/cne.25620\">10.1002/cne.25620</a>.","apa":"Reiner, A., Medina, L., Abellan, A., Deng, Y., Toledo, C. A. B., Luksch, H., … Karten, H. J. (2024). Neurochemistry and circuit organization of the lateral spiriform nucleus of birds: A uniquely nonmammalian direct pathway component of the basal ganglia. <i>Journal of Comparative Neurology</i>. Wiley. <a href=\"https://doi.org/10.1002/cne.25620\">https://doi.org/10.1002/cne.25620</a>","chicago":"Reiner, Anton, Loreta Medina, Antonio Abellan, Yunping Deng, Claudio A.B. Toledo, Harald Luksch, Tomas A Vega Zuniga, Nell B. Riley, William Hodos, and Harvey J. Karten. “Neurochemistry and Circuit Organization of the Lateral Spiriform Nucleus of Birds: A Uniquely Nonmammalian Direct Pathway Component of the Basal Ganglia.” <i>Journal of Comparative Neurology</i>. Wiley, 2024. <a href=\"https://doi.org/10.1002/cne.25620\">https://doi.org/10.1002/cne.25620</a>.","ama":"Reiner A, Medina L, Abellan A, et al. Neurochemistry and circuit organization of the lateral spiriform nucleus of birds: A uniquely nonmammalian direct pathway component of the basal ganglia. <i>Journal of Comparative Neurology</i>. 2024;532(5). doi:<a href=\"https://doi.org/10.1002/cne.25620\">10.1002/cne.25620</a>"},"title":"Neurochemistry and circuit organization of the lateral spiriform nucleus of birds: A uniquely nonmammalian direct pathway component of the basal ganglia","OA_place":"repository","type":"journal_article","acknowledgement":"We gratefully thank Marion Joni, Tony Laverghetta, Sherry Cuthbertson, Gary Henderson, and Patricia Lindaman for technical assistance. The research presented here has been supported by NIH grants NS-16857, NS-19620, NS-28721, and EY-05298, and The Methodist Hospitals Endowed Professorship in Neuroscience (A. R.), by grant number 09/50623-9 from the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (C. A. B. T.), by NIH grant EY-00735 (W. H.), and by NIH grants NS-12078 and EY-02145 (H. J. K.).","author":[{"first_name":"Anton","last_name":"Reiner","full_name":"Reiner, Anton"},{"last_name":"Medina","first_name":"Loreta","full_name":"Medina, Loreta"},{"first_name":"Antonio","last_name":"Abellan","full_name":"Abellan, Antonio"},{"last_name":"Deng","first_name":"Yunping","full_name":"Deng, Yunping"},{"first_name":"Claudio A.B.","last_name":"Toledo","full_name":"Toledo, Claudio A.B."},{"full_name":"Luksch, Harald","last_name":"Luksch","first_name":"Harald"},{"first_name":"Tomas A","last_name":"Vega Zuniga","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87","full_name":"Vega Zuniga, Tomas A"},{"first_name":"Nell B.","last_name":"Riley","full_name":"Riley, Nell B."},{"full_name":"Hodos, William","first_name":"William","last_name":"Hodos"},{"first_name":"Harvey J.","last_name":"Karten","full_name":"Karten, Harvey J."}],"status":"public","article_type":"original","department":[{"_id":"MaJö"}],"publication":"Journal of Comparative Neurology","oa":1,"date_published":"2024-05-01T00:00:00Z","external_id":{"pmid":["38733146"],"isi":["001217825300001"]},"language":[{"iso":"eng"}],"volume":532,"abstract":[{"lang":"eng","text":"We used diverse methods to characterize the role of avian lateral spiriform nucleus (SpL) in basal ganglia motor function. Connectivity analysis showed that SpL receives input from globus pallidus (GP), and the intrapeduncular nucleus (INP) located ventromedial to GP, whose neurons express numerous striatal markers. SpL-projecting GP neurons were large and aspiny, while SpL-projecting INP neurons were medium sized and spiny. Connectivity analysis further showed that SpL receives inputs from subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr), and that the SNr also receives inputs from GP, INP, and STN. Neurochemical analysis showed that SpL neurons express ENK, GAD, and a variety of pallidal neuron markers, and receive GABAergic terminals, some of which also contain DARPP32, consistent with GP pallidal and INP striatal inputs. Connectivity and neurochemical analysis showed that the SpL input to tectum prominently ends on GABAA receptor-enriched tectobulbar neurons. Behavioral studies showed that lesions of SpL impair visuomotor behaviors involving tracking and pecking moving targets. Our results suggest that SpL modulates brainstem-projecting tectobulbar neurons in a manner comparable to the demonstrated influence of GP internus on motor thalamus and of SNr on tectobulbar neurons in mammals. Given published data in amphibians and reptiles, it seems likely the SpL circuit represents a major direct pathway-type circuit by which the basal ganglia exerts its motor influence in nonmammalian tetrapods. The present studies also show that avian striatum is divided into three spatially segregated territories with differing connectivity, a medial striato-nigral territory, a dorsolateral striato-GP territory, and the ventrolateral INP motor territory."}],"year":"2024","article_processing_charge":"No","isi":1,"publication_identifier":{"issn":["0021-9967"],"eissn":["1096-9861"]}},{"related_material":{"link":[{"relation":"software","url":"https://doi.org/10.5281/zenodo.11130587"}],"record":[{"relation":"research_data","id":"15385","status":"public"}]},"project":[{"call_identifier":"H2020","_id":"2634E9D2-B435-11E9-9278-68D0E5697425","name":"Circuits of Visual Attention","grant_number":"756502"}],"DOAJ_listed":"1","file_date_updated":"2025-01-09T10:39:41Z","scopus_import":"1","has_accepted_license":"1","day":"10","publication_status":"published","publisher":"Public Library of Science","doi":"10.1371/journal.pbio.3002668","quality_controlled":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","_id":"17142","article_number":"e3002668","pmid":1,"intvolume":"        22","oa_version":"Published Version","date_updated":"2025-09-08T07:57:11Z","APC_amount":"6081,83 EUR","date_created":"2024-06-16T22:01:05Z","type":"journal_article","OA_place":"publisher","ddc":["570"],"title":"Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice","author":[{"first_name":"Laura","last_name":"Burnett","id":"3B717F68-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8937-410X","full_name":"Burnett, Laura"},{"full_name":"Koppensteiner, Peter","orcid":"0000-0002-3509-1948","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","first_name":"Peter","last_name":"Koppensteiner"},{"full_name":"Symonova, Olga","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2012-9947","first_name":"Olga","last_name":"Symonova"},{"orcid":"0000-0002-2634-6283","id":"93ac43e8-8599-11eb-9b86-f6efb0a4c207","full_name":"Masson, Tomas","last_name":"Masson","first_name":"Tomas"},{"full_name":"Vega Zuniga, Tomas A","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87","last_name":"Vega Zuniga","first_name":"Tomas A"},{"id":"475990FE-F248-11E8-B48F-1D18A9856A87","full_name":"Contreras, Ximena","first_name":"Ximena","last_name":"Contreras"},{"full_name":"Rülicke, Thomas","last_name":"Rülicke","first_name":"Thomas"},{"last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Gaia","last_name":"Novarino","full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178"},{"full_name":"Jösch, Maximilian A","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3937-1330","first_name":"Maximilian A","last_name":"Jösch"}],"status":"public","acknowledgement":"This work was supported by a European Research Council Starting Grant 756502 (MJ). ","OA_type":"gold","file":[{"relation":"main_file","content_type":"application/pdf","file_name":"2024_PloS_Burnett.pdf","file_id":"18805","checksum":"496e1aa4fd5b92b7e4087ecc2c964133","date_created":"2025-01-09T10:39:41Z","creator":"dernst","date_updated":"2025-01-09T10:39:41Z","success":1,"access_level":"open_access","file_size":4016568}],"corr_author":"1","ec_funded":1,"citation":{"short":"L. Burnett, P. Koppensteiner, O. Symonova, T. Masson, T.A. Vega Zuniga, X. Contreras, T. Rülicke, R. Shigemoto, G. Novarino, M.A. Jösch, PLoS Biology 22 (2024).","ieee":"L. Burnett <i>et al.</i>, “Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice,” <i>PLoS Biology</i>, vol. 22. Public Library of Science, 2024.","mla":"Burnett, Laura, et al. “Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice.” <i>PLoS Biology</i>, vol. 22, e3002668, Public Library of Science, 2024, doi:<a href=\"https://doi.org/10.1371/journal.pbio.3002668\">10.1371/journal.pbio.3002668</a>.","apa":"Burnett, L., Koppensteiner, P., Symonova, O., Masson, T., Vega Zuniga, T. A., Contreras, X., … Jösch, M. A. (2024). Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. <i>PLoS Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pbio.3002668\">https://doi.org/10.1371/journal.pbio.3002668</a>","chicago":"Burnett, Laura, Peter Koppensteiner, Olga Symonova, Tomas Masson, Tomas A Vega Zuniga, Ximena Contreras, Thomas Rülicke, Ryuichi Shigemoto, Gaia Novarino, and Maximilian A Jösch. “Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice.” <i>PLoS Biology</i>. Public Library of Science, 2024. <a href=\"https://doi.org/10.1371/journal.pbio.3002668\">https://doi.org/10.1371/journal.pbio.3002668</a>.","ama":"Burnett L, Koppensteiner P, Symonova O, et al. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. <i>PLoS Biology</i>. 2024;22. doi:<a href=\"https://doi.org/10.1371/journal.pbio.3002668\">10.1371/journal.pbio.3002668</a>","ista":"Burnett L, Koppensteiner P, Symonova O, Masson T, Vega Zuniga TA, Contreras X, Rülicke T, Shigemoto R, Novarino G, Jösch MA. 2024. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. PLoS Biology. 22, e3002668."},"month":"06","article_processing_charge":"Yes","year":"2024","abstract":[{"text":"Despite the diverse genetic origins of autism spectrum disorders (ASDs), affected individuals share strikingly similar and correlated behavioural traits that include perceptual and sensory processing challenges. Notably, the severity of these sensory symptoms is often predictive of the expression of other autistic traits. However, the origin of these perceptual deficits remains largely elusive. Here, we show a recurrent impairment in visual threat perception that is similarly impaired in 3 independent mouse models of ASD with different molecular aetiologies. Interestingly, this deficit is associated with reduced avoidance of threatening environments—a nonperceptual trait. Focusing on a common cause of ASDs, the Setd5 gene mutation, we define the molecular mechanism. We show that the perceptual impairment is caused by a potassium channel (Kv1)-mediated hypoexcitability in a subcortical node essential for the initiation of escape responses, the dorsal periaqueductal grey (dPAG). Targeted pharmacological Kv1 blockade rescued both perceptual and place avoidance deficits, causally linking seemingly unrelated trait deficits to the dPAG. Furthermore, we show that different molecular mechanisms converge on similar behavioural phenotypes by demonstrating that the autism models Cul3 and Ptchd1, despite having similar behavioural phenotypes, differ in their functional and molecular alteration. Our findings reveal a link between rapid perception controlled by subcortical pathways and appropriate learned interactions with the environment and define a nondevelopmental source of such deficits in ASD.","lang":"eng"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"publication_identifier":{"issn":["1544-9173"],"eissn":["1545-7885"]},"isi":1,"date_published":"2024-06-10T00:00:00Z","oa":1,"department":[{"_id":"RySh"},{"_id":"GaNo"},{"_id":"MaJö"}],"publication":"PLoS Biology","article_type":"original","volume":22,"external_id":{"isi":["001246176800003"],"pmid":["38857283"]},"language":[{"iso":"eng"}]},{"file_date_updated":"2024-12-09T12:54:55Z","has_accepted_license":"1","related_material":{"record":[{"relation":"used_in_publication","id":"19076","status":"public"}]},"project":[{"name":"Connecting sensory with motor processing in the superior colliculus","_id":"264FEA02-B435-11E9-9278-68D0E5697425","grant_number":"ALTF 1098-2017"},{"grant_number":"LT000256","_id":"266D407A-B435-11E9-9278-68D0E5697425","name":"Neuronal networks of salience and spatial detection in the murine superior colliculus"},{"call_identifier":"H2020","grant_number":"756502","name":"Circuits of Visual Attention","_id":"2634E9D2-B435-11E9-9278-68D0E5697425"},{"name":"Action Selection in the Midbrain: Neuromodulation of Visuomotor Senses","_id":"bdaf81a8-d553-11ed-ba76-c95961984540","grant_number":"101086580"}],"oa_version":"Published Version","date_created":"2024-11-22T13:48:12Z","date_updated":"2026-06-18T18:12:08Z","day":"09","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"18579","doi":"10.15479/AT:ISTA:18579","publisher":"Institute of Science and Technology Austria","corr_author":"1","file":[{"file_id":"18625","relation":"main_file","content_type":"application/x-zip-compressed","file_name":"electro_physiology_data.zip","date_updated":"2024-12-09T10:24:25Z","creator":"symonova","checksum":"8b13990ca1a458ae3f3ae54c2e888564","date_created":"2024-12-06T13:28:18Z","access_level":"open_access","file_size":800647957},{"file_id":"18636","relation":"main_file","content_type":"application/x-zip-compressed","file_name":"NN_vLGN_Ca_data.zip","date_updated":"2024-12-09T10:21:10Z","creator":"symonova","success":1,"date_created":"2024-12-09T10:21:10Z","checksum":"c5a4d71c5f29c009c3d96a3244532afa","access_level":"open_access","file_size":828410832},{"checksum":"63651df0186196969553dc48b467f6ab","date_created":"2024-12-09T12:54:55Z","success":1,"creator":"symonova","date_updated":"2024-12-09T12:54:55Z","file_name":"readme.txt","content_type":"text/plain","relation":"main_file","file_id":"18637","file_size":505,"access_level":"open_access"}],"month":"12","citation":{"ama":"Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18579\">10.15479/AT:ISTA:18579</a>","mla":"Vega Zuniga, Tomas A., et al. <i>A Thalamic Hub-and-Spoke Network Enables Visual Perception during Action by Coordinating Visuomotor Dynamics</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18579\">10.15479/AT:ISTA:18579</a>.","ieee":"T. A. Vega Zuniga, A. L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt, and M. A. Jösch, “A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics.” Institute of Science and Technology Austria, 2024.","short":"T.A. Vega Zuniga, A.L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt, M.A. Jösch, (2024).","apa":"Vega Zuniga, T. A., Sumser, A. L., Symonova, O., Koppensteiner, P., Schmidt, F., &#38; Jösch, M. A. (2024). A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:18579\">https://doi.org/10.15479/AT:ISTA:18579</a>","chicago":"Vega Zuniga, Tomas A, Anton L Sumser, Olga Symonova, Peter Koppensteiner, Florian Schmidt, and Maximilian A Jösch. “A Thalamic Hub-and-Spoke Network Enables Visual Perception during Action by Coordinating Visuomotor Dynamics.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:18579\">https://doi.org/10.15479/AT:ISTA:18579</a>.","ista":"Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. 2024. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:18579\">10.15479/AT:ISTA:18579</a>."},"ec_funded":1,"title":"A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics","OA_place":"publisher","ddc":["570"],"type":"research_data","acknowledgement":"Freyja Lange, Michael Schunn, and Todor Asenov","author":[{"last_name":"Vega Zuniga","first_name":"Tomas A","full_name":"Vega Zuniga, Tomas A","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-4792-1881","id":"3320A096-F248-11E8-B48F-1D18A9856A87","full_name":"Sumser, Anton L","last_name":"Sumser","first_name":"Anton L"},{"last_name":"Symonova","first_name":"Olga","orcid":"0000-0003-2012-9947","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87","full_name":"Symonova, Olga"},{"first_name":"Peter","last_name":"Koppensteiner","full_name":"Koppensteiner, Peter","orcid":"0000-0002-3509-1948","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87"},{"id":"A2EF226A-AF19-11E9-924C-0525E6697425","full_name":"Schmidt, Florian","first_name":"Florian","last_name":"Schmidt"},{"first_name":"Maximilian A","last_name":"Jösch","full_name":"Jösch, Maximilian A","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3937-1330"}],"status":"public","oa":1,"department":[{"_id":"MaJö"}],"date_published":"2024-12-09T00:00:00Z","abstract":[{"text":"Electrophysiological, calcium two-photon recordings and behavioral data for Vega-Zuniga et al.  Relevant information can be found in the 'README.txt' files. ","lang":"eng"}],"year":"2024","article_processing_charge":"No","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"PreCl"},{"_id":"M-Shop"},{"_id":"Bio"},{"_id":"LifeSc"}]},{"publication_identifier":{"issn":["0021-9967"],"eissn":["1096-9861"]},"isi":1,"year":"2022","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Neurons can change their classical neurotransmitters during ontogeny, sometimes going through stages of dual release. Here, we explored the development of the neurotransmitter identity of neurons of the avian nucleus isthmi parvocellularis (Ipc), whose axon terminals are retinotopically arranged in the optic tectum (TeO) and exert a focal gating effect upon the ascending transmission of retinal inputs. Although cholinergic and glutamatergic markers are both found in Ipc neurons and terminals of adult pigeons and chicks, the mRNA expression of the vesicular acetylcholine transporter, VAChT, is weak or absent. To explore how the Ipc neurotransmitter identity is established during ontogeny, we analyzed the expression of mRNAs coding for cholinergic (ChAT, VAChT, and CHT) and glutamatergic (VGluT2 and VGluT3) markers in chick embryos at different developmental stages. We found that between E12 and E18, Ipc neurons expressed all cholinergic mRNAs and also VGluT2 mRNA; however, from E16 through posthatch stages, VAChT mRNA expression was specifically diminished. Our ex vivo deposits of tracer crystals and intracellular filling experiments revealed that Ipc axons exhibit a mature paintbrush morphology late in development, experiencing marked morphological transformations during the period of presumptive dual vesicular transmitter release. Additionally, although ChAT protein immunoassays increasingly label the growing Ipc axon, this labeling was consistently restricted to sparse portions of the terminal branches. Combined, these results suggest that the synthesis of glutamate and acetylcholine, and their vesicular release, is complexly linked to the developmental processes of branching, growing and remodeling of these unique axons."}],"volume":530,"language":[{"iso":"eng"}],"external_id":{"isi":["000686420000001"],"pmid":["34363623"]},"date_published":"2022-02-01T00:00:00Z","article_type":"original","department":[{"_id":"MaJö"}],"publication":"Journal of Comparative Neurology","status":"public","author":[{"full_name":"Reyes‐Pinto, Rosana","first_name":"Rosana","last_name":"Reyes‐Pinto"},{"first_name":"José L.","last_name":"Ferrán","full_name":"Ferrán, José L."},{"last_name":"Vega Zuniga","first_name":"Tomas A","full_name":"Vega Zuniga, Tomas A","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87"},{"full_name":"González‐Cabrera, Cristian","first_name":"Cristian","last_name":"González‐Cabrera"},{"last_name":"Luksch","first_name":"Harald","full_name":"Luksch, Harald"},{"full_name":"Mpodozis, Jorge","last_name":"Mpodozis","first_name":"Jorge"},{"full_name":"Puelles, Luis","first_name":"Luis","last_name":"Puelles"},{"first_name":"Gonzalo J.","last_name":"Marín","full_name":"Marín, Gonzalo J."}],"acknowledgement":"This work was supported by FONDECYT grants 1151432 and 1210169 to Gonzalo J. Marín. FONDECYT grant 1210069 to Jorge Mpodozis. Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI) and European Regional Development Fund (FEDER), PGC2018-098229-B-100 to José L Ferrán. Spanish Ministry of Economy and Competitiveness Excellency Grant BFU2014-57516P (with European Community FEDER support), and a Seneca Foundation (Autonomous Community of Murcia) Excellency Research contract, ref: 19904/ GERM/15; project name: Genoarchitectonic Brain Development and Applications to Neurodegenerative Diseases and Cancer (5672 Fundación Séneca) to Luis Puelles. The authors gratefully acknowledge the valuable editorial help provided by Sara Fernández-Collemann. The authors also thank Elisa Sentis and Solano Henríquez for expert technical help.","type":"journal_article","title":"Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum","month":"02","citation":{"ista":"Reyes‐Pinto R, Ferrán JL, Vega Zuniga TA, González‐Cabrera C, Luksch H, Mpodozis J, Puelles L, Marín GJ. 2022. Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum. Journal of Comparative Neurology. 530(2), 553–573.","ieee":"R. Reyes‐Pinto <i>et al.</i>, “Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum,” <i>Journal of Comparative Neurology</i>, vol. 530, no. 2. Wiley, pp. 553–573, 2022.","chicago":"Reyes‐Pinto, Rosana, José L. Ferrán, Tomas A Vega Zuniga, Cristian González‐Cabrera, Harald Luksch, Jorge Mpodozis, Luis Puelles, and Gonzalo J. Marín. “Change in the Neurochemical Signature and Morphological Development of the Parvocellular Isthmic Projection to the Avian Tectum.” <i>Journal of Comparative Neurology</i>. Wiley, 2022. <a href=\"https://doi.org/10.1002/cne.25229\">https://doi.org/10.1002/cne.25229</a>.","short":"R. Reyes‐Pinto, J.L. Ferrán, T.A. Vega Zuniga, C. González‐Cabrera, H. Luksch, J. Mpodozis, L. Puelles, G.J. Marín, Journal of Comparative Neurology 530 (2022) 553–573.","apa":"Reyes‐Pinto, R., Ferrán, J. L., Vega Zuniga, T. A., González‐Cabrera, C., Luksch, H., Mpodozis, J., … Marín, G. J. (2022). Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum. <i>Journal of Comparative Neurology</i>. Wiley. <a href=\"https://doi.org/10.1002/cne.25229\">https://doi.org/10.1002/cne.25229</a>","mla":"Reyes‐Pinto, Rosana, et al. “Change in the Neurochemical Signature and Morphological Development of the Parvocellular Isthmic Projection to the Avian Tectum.” <i>Journal of Comparative Neurology</i>, vol. 530, no. 2, Wiley, 2022, pp. 553–73, doi:<a href=\"https://doi.org/10.1002/cne.25229\">10.1002/cne.25229</a>.","ama":"Reyes‐Pinto R, Ferrán JL, Vega Zuniga TA, et al. Change in the neurochemical signature and morphological development of the parvocellular isthmic projection to the avian tectum. <i>Journal of Comparative Neurology</i>. 2022;530(2):553-573. doi:<a href=\"https://doi.org/10.1002/cne.25229\">10.1002/cne.25229</a>"},"doi":"10.1002/cne.25229","publisher":"Wiley","_id":"9955","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","quality_controlled":"1","day":"01","publication_status":"published","page":"553-573","date_updated":"2023-08-11T10:58:17Z","date_created":"2021-08-23T08:40:59Z","pmid":1,"oa_version":"None","intvolume":"       530","scopus_import":"1","issue":"2"},{"article_type":"original","publication":"Scientific Reports","department":[{"_id":"MaJö"}],"oa":1,"date_published":"2020-10-01T00:00:00Z","language":[{"iso":"eng"}],"external_id":{"pmid":["33004866"],"isi":["000577142600032"]},"volume":10,"abstract":[{"text":"The parabigeminal nucleus (PBG) is the mammalian homologue to the isthmic complex of other vertebrates. Optogenetic stimulation of the PBG induces freezing and escape in mice, a result thought to be caused by a PBG projection to the central nucleus of the amygdala. However, the isthmic complex, including the PBG, has been classically considered satellite nuclei of the Superior Colliculus (SC), which upon stimulation of its medial part also triggers fear and avoidance reactions. As the PBG-SC connectivity is not well characterized, we investigated whether the topology of the PBG projection to the SC could be related to the behavioral consequences of PBG stimulation. To that end, we performed immunohistochemistry, in situ hybridization and neural tracer injections in the SC and PBG in a diurnal rodent, the Octodon degus. We found that all PBG neurons expressed both glutamatergic and cholinergic markers and were distributed in clearly defined anterior (aPBG) and posterior (pPBG) subdivisions. The pPBG is connected reciprocally and topographically to the ipsilateral SC, whereas the aPBG receives afferent axons from the ipsilateral SC and projected exclusively to the contralateral SC. This contralateral projection forms a dense field of terminals that is restricted to the medial SC, in correspondence with the SC representation of the aerial binocular field which, we also found, in O. degus prompted escape reactions upon looming stimulation. Therefore, this specialized topography allows binocular interactions in the SC region controlling responses to aerial predators, suggesting a link between the mechanisms by which the SC and PBG produce defensive behaviors.","lang":"eng"}],"year":"2020","article_processing_charge":"No","isi":1,"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"publication_identifier":{"eissn":["2045-2322"]},"file":[{"file_name":"2020_ScientificReport_Deichler.pdf","content_type":"application/pdf","relation":"main_file","file_id":"8651","checksum":"f6dd99954f1c0ffb4da5a1d2d739bf31","date_created":"2020-10-12T12:39:10Z","success":1,"date_updated":"2020-10-12T12:39:10Z","creator":"dernst","access_level":"open_access","file_size":3906744}],"month":"10","citation":{"ama":"Deichler A, Carrasco D, Lopez-Jury L, et al. A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents. <i>Scientific Reports</i>. 2020;10. doi:<a href=\"https://doi.org/10.1038/s41598-020-72848-0\">10.1038/s41598-020-72848-0</a>","apa":"Deichler, A., Carrasco, D., Lopez-Jury, L., Vega Zuniga, T. A., Marquez, N., Mpodozis, J., &#38; Marin, G. (2020). A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-020-72848-0\">https://doi.org/10.1038/s41598-020-72848-0</a>","mla":"Deichler, Alfonso, et al. “A Specialized Reciprocal Connectivity Suggests a Link between the Mechanisms by Which the Superior Colliculus and Parabigeminal Nucleus Produce Defensive Behaviors in Rodents.” <i>Scientific Reports</i>, vol. 10, 16220, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41598-020-72848-0\">10.1038/s41598-020-72848-0</a>.","ieee":"A. Deichler <i>et al.</i>, “A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents,” <i>Scientific Reports</i>, vol. 10. Springer Nature, 2020.","chicago":"Deichler, Alfonso, Denisse Carrasco, Luciana Lopez-Jury, Tomas A Vega Zuniga, Natalia Marquez, Jorge Mpodozis, and Gonzalo Marin. “A Specialized Reciprocal Connectivity Suggests a Link between the Mechanisms by Which the Superior Colliculus and Parabigeminal Nucleus Produce Defensive Behaviors in Rodents.” <i>Scientific Reports</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41598-020-72848-0\">https://doi.org/10.1038/s41598-020-72848-0</a>.","short":"A. Deichler, D. Carrasco, L. Lopez-Jury, T.A. Vega Zuniga, N. Marquez, J. Mpodozis, G. Marin, Scientific Reports 10 (2020).","ista":"Deichler A, Carrasco D, Lopez-Jury L, Vega Zuniga TA, Marquez N, Mpodozis J, Marin G. 2020. A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents. Scientific Reports. 10, 16220."},"title":"A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents","ddc":["570"],"type":"journal_article","acknowledgement":"We thank Elisa Sentis and Solano Henriquez for their expert technical assistance. Dr. David Sterratt for his helpful advice in using the Retistruct package. Dr. Joao Botelho for his valuable assistance in scanning the retinas. To Mrs. Diane Greenstein for kindly reading and correcting our manuscript. Macarena Ruiz for her helpful comments during figures elaboration. Dr. Alexia Nunez-Parra for kindly providing us with the transgenic mouse line. Dr. Harald Luksch for granting us access to the confocal microscope at his lab. This study was supported by: FONDECYT 1151432 (to G.M.), FONDECYT 1170027 (to J.M.) and Doctoral fellowship CONICYT 21161599 (to A.D.).","status":"public","author":[{"full_name":"Deichler, Alfonso","first_name":"Alfonso","last_name":"Deichler"},{"full_name":"Carrasco, Denisse","first_name":"Denisse","last_name":"Carrasco"},{"last_name":"Lopez-Jury","first_name":"Luciana","full_name":"Lopez-Jury, Luciana"},{"id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87","full_name":"Vega Zuniga, Tomas A","first_name":"Tomas A","last_name":"Vega Zuniga"},{"last_name":"Marquez","first_name":"Natalia","full_name":"Marquez, Natalia"},{"full_name":"Mpodozis, Jorge","first_name":"Jorge","last_name":"Mpodozis"},{"last_name":"Marin","first_name":"Gonzalo","full_name":"Marin, Gonzalo"}],"oa_version":"Published Version","intvolume":"        10","pmid":1,"article_number":"16220","date_created":"2020-10-11T22:01:14Z","date_updated":"2026-04-03T09:26:41Z","day":"01","publication_status":"published","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","_id":"8643","quality_controlled":"1","doi":"10.1038/s41598-020-72848-0","publisher":"Springer Nature","scopus_import":"1","file_date_updated":"2020-10-12T12:39:10Z","has_accepted_license":"1"},{"volume":94,"language":[{"iso":"eng"}],"external_id":{"isi":["000522856600004"],"pmid":["31751995"]},"date_published":"2020-01-01T00:00:00Z","publication":"Brain, Behavior and Evolution","department":[{"_id":"MaJö"}],"article_type":"original","publication_identifier":{"issn":["0006-8977"],"eissn":["1421-9743"]},"isi":1,"article_processing_charge":"No","year":"2020","abstract":[{"lang":"eng","text":"Nocturnal animals that rely on their visual system for foraging, mating, and navigation usually exhibit specific traits associated with living in scotopic conditions. Most nocturnal birds have several visual specializations, such as enlarged eyes and an increased orbital convergence. However, the actual role of binocular vision in nocturnal foraging is still debated. Nightjars (Aves: Caprimulgidae) are predators that actively pursue and capture flying insects in crepuscular and nocturnal environments, mainly using a conspicuous “sit-and-wait” tactic on which pursuit begins with an insect flying over the bird that sits on the ground. In this study, we describe the visual system of the band-winged nightjar (Systellura longirostris), with emphasis on anatomical features previously described as relevant for nocturnal birds. Orbit convergence, determined by 3D scanning of the skull, was 73.28°. The visual field, determined by ophthalmoscopic reflex, exhibits an area of maximum binocular overlap of 42°, and it is dorsally oriented. The eyes showed a nocturnal-like normalized corneal aperture/axial length index. Retinal ganglion cells (RGCs) were relatively scant, and distributed in an unusual oblique-band pattern, with higher concentrations in the ventrotemporal quadrant. Together, these results indicate that the band-winged nightjar exhibits a retinal specialization associated with the binocular area of their dorsal visual field, a relevant area for pursuit triggering and prey attacks. The RGC distribution observed is unusual among birds, but similar to that of some visually dependent insectivorous bats, suggesting that those features might be convergent in relation to feeding strategies."}],"citation":{"ista":"Salazar JE, Severin D, Vega Zuniga TA, Fernández-Aburto P, Deichler A, Sallaberry A. M, Mpodozis J. 2020. Anatomical specializations related to foraging in the visual system of a nocturnal insectivorous bird, the band-winged nightjar (Aves: Caprimulgiformes). Brain, Behavior and Evolution. 94(1–4), 27–36.","ama":"Salazar JE, Severin D, Vega Zuniga TA, et al. Anatomical specializations related to foraging in the visual system of a nocturnal insectivorous bird, the band-winged nightjar (Aves: Caprimulgiformes). <i>Brain, Behavior and Evolution</i>. 2020;94(1-4):27-36. doi:<a href=\"https://doi.org/10.1159/000504162\">10.1159/000504162</a>","mla":"Salazar, Juan Esteban, et al. “Anatomical Specializations Related to Foraging in the Visual System of a Nocturnal Insectivorous Bird, the Band-Winged Nightjar (Aves: Caprimulgiformes).” <i>Brain, Behavior and Evolution</i>, vol. 94, no. 1–4, Karger Publishers, 2020, pp. 27–36, doi:<a href=\"https://doi.org/10.1159/000504162\">10.1159/000504162</a>.","ieee":"J. E. Salazar <i>et al.</i>, “Anatomical specializations related to foraging in the visual system of a nocturnal insectivorous bird, the band-winged nightjar (Aves: Caprimulgiformes),” <i>Brain, Behavior and Evolution</i>, vol. 94, no. 1–4. Karger Publishers, pp. 27–36, 2020.","apa":"Salazar, J. E., Severin, D., Vega Zuniga, T. A., Fernández-Aburto, P., Deichler, A., Sallaberry A., M., &#38; Mpodozis, J. (2020). Anatomical specializations related to foraging in the visual system of a nocturnal insectivorous bird, the band-winged nightjar (Aves: Caprimulgiformes). <i>Brain, Behavior and Evolution</i>. Karger Publishers. <a href=\"https://doi.org/10.1159/000504162\">https://doi.org/10.1159/000504162</a>","chicago":"Salazar, Juan Esteban, Daniel Severin, Tomas A Vega Zuniga, Pedro Fernández-Aburto, Alfonso Deichler, Michel Sallaberry A., and Jorge Mpodozis. “Anatomical Specializations Related to Foraging in the Visual System of a Nocturnal Insectivorous Bird, the Band-Winged Nightjar (Aves: Caprimulgiformes).” <i>Brain, Behavior and Evolution</i>. Karger Publishers, 2020. <a href=\"https://doi.org/10.1159/000504162\">https://doi.org/10.1159/000504162</a>.","short":"J.E. Salazar, D. Severin, T.A. Vega Zuniga, P. Fernández-Aburto, A. Deichler, M. Sallaberry A., J. Mpodozis, Brain, Behavior and Evolution 94 (2020) 27–36."},"month":"01","status":"public","author":[{"full_name":"Salazar, Juan Esteban","last_name":"Salazar","first_name":"Juan Esteban"},{"last_name":"Severin","first_name":"Daniel","full_name":"Severin, Daniel"},{"id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87","full_name":"Vega Zuniga, Tomas A","last_name":"Vega Zuniga","first_name":"Tomas A"},{"first_name":"Pedro","last_name":"Fernández-Aburto","full_name":"Fernández-Aburto, Pedro"},{"first_name":"Alfonso","last_name":"Deichler","full_name":"Deichler, Alfonso"},{"full_name":"Sallaberry A., Michel","first_name":"Michel","last_name":"Sallaberry A."},{"last_name":"Mpodozis","first_name":"Jorge","full_name":"Mpodozis, Jorge"}],"type":"journal_article","title":"Anatomical specializations related to foraging in the visual system of a nocturnal insectivorous bird, the band-winged nightjar (Aves: Caprimulgiformes)","page":"27-36","date_updated":"2024-02-22T15:18:34Z","date_created":"2019-12-09T09:04:13Z","pmid":1,"intvolume":"        94","oa_version":"None","publisher":"Karger Publishers","doi":"10.1159/000504162","quality_controlled":"1","_id":"7160","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","day":"01","publication_status":"published","scopus_import":"1","issue":"1-4"},{"scopus_import":"1","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pubmed/30026198","open_access":"1"}],"issue":"32","page":"E7615-E7623","date_updated":"2023-09-19T14:35:36Z","date_created":"2019-02-14T14:33:34Z","pmid":1,"intvolume":"       115","oa_version":"Submitted Version","publisher":"National Academy of Sciences","doi":"10.1073/pnas.1804517115","quality_controlled":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","_id":"6010","day":"07","publication_status":"published","citation":{"ama":"Garrido-Charad F, Vega Zuniga TA, Gutiérrez-Ibáñez C, et al. “Shepherd’s crook” neurons drive and synchronize the enhancing and suppressive mechanisms of the midbrain stimulus selection network. <i>Proceedings of the National Academy of Sciences</i>. 2018;115(32):E7615-E7623. doi:<a href=\"https://doi.org/10.1073/pnas.1804517115\">10.1073/pnas.1804517115</a>","mla":"Garrido-Charad, Florencia, et al. ““Shepherd’s Crook” Neurons Drive and Synchronize the Enhancing and Suppressive Mechanisms of the Midbrain Stimulus Selection Network.” <i>Proceedings of the National Academy of Sciences</i>, vol. 115, no. 32, National Academy of Sciences, 2018, pp. E7615–23, doi:<a href=\"https://doi.org/10.1073/pnas.1804517115\">10.1073/pnas.1804517115</a>.","chicago":"Garrido-Charad, Florencia, Tomas A Vega Zuniga, Cristián Gutiérrez-Ibáñez, Pedro Fernandez, Luciana López-Jury, Cristian González-Cabrera, Harvey J. Karten, Harald Luksch, and Gonzalo J. Marín. ““Shepherd’s Crook” Neurons Drive and Synchronize the Enhancing and Suppressive Mechanisms of the Midbrain Stimulus Selection Network.” <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences, 2018. <a href=\"https://doi.org/10.1073/pnas.1804517115\">https://doi.org/10.1073/pnas.1804517115</a>.","apa":"Garrido-Charad, F., Vega Zuniga, T. A., Gutiérrez-Ibáñez, C., Fernandez, P., López-Jury, L., González-Cabrera, C., … Marín, G. J. (2018). “Shepherd’s crook” neurons drive and synchronize the enhancing and suppressive mechanisms of the midbrain stimulus selection network. <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1804517115\">https://doi.org/10.1073/pnas.1804517115</a>","ieee":"F. Garrido-Charad <i>et al.</i>, ““Shepherd’s crook” neurons drive and synchronize the enhancing and suppressive mechanisms of the midbrain stimulus selection network,” <i>Proceedings of the National Academy of Sciences</i>, vol. 115, no. 32. National Academy of Sciences, pp. E7615–E7623, 2018.","short":"F. Garrido-Charad, T.A. Vega Zuniga, C. Gutiérrez-Ibáñez, P. Fernandez, L. López-Jury, C. González-Cabrera, H.J. Karten, H. Luksch, G.J. Marín, Proceedings of the National Academy of Sciences 115 (2018) E7615–E7623.","ista":"Garrido-Charad F, Vega Zuniga TA, Gutiérrez-Ibáñez C, Fernandez P, López-Jury L, González-Cabrera C, Karten HJ, Luksch H, Marín GJ. 2018. “Shepherd’s crook” neurons drive and synchronize the enhancing and suppressive mechanisms of the midbrain stimulus selection network. Proceedings of the National Academy of Sciences. 115(32), E7615–E7623."},"month":"08","status":"public","author":[{"first_name":"Florencia","last_name":"Garrido-Charad","full_name":"Garrido-Charad, Florencia"},{"full_name":"Vega Zuniga, Tomas A","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87","last_name":"Vega Zuniga","first_name":"Tomas A"},{"last_name":"Gutiérrez-Ibáñez","first_name":"Cristián","full_name":"Gutiérrez-Ibáñez, Cristián"},{"full_name":"Fernandez, Pedro","last_name":"Fernandez","first_name":"Pedro"},{"last_name":"López-Jury","first_name":"Luciana","full_name":"López-Jury, Luciana"},{"last_name":"González-Cabrera","first_name":"Cristian","full_name":"González-Cabrera, Cristian"},{"full_name":"Karten, Harvey J.","first_name":"Harvey J.","last_name":"Karten"},{"full_name":"Luksch, Harald","last_name":"Luksch","first_name":"Harald"},{"last_name":"Marín","first_name":"Gonzalo J.","full_name":"Marín, Gonzalo J."}],"type":"journal_article","title":"“Shepherd’s crook” neurons drive and synchronize the enhancing and suppressive mechanisms of the midbrain stimulus selection network","volume":115,"external_id":{"isi":["000440982000020"],"pmid":["30026198"]},"language":[{"iso":"eng"}],"date_published":"2018-08-07T00:00:00Z","oa":1,"department":[{"_id":"MaJö"}],"publication":"Proceedings of the National Academy of Sciences","isi":1,"publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"article_processing_charge":"No","year":"2018","abstract":[{"text":"The optic tectum (TeO), or superior colliculus, is a multisensory midbrain center that organizes spatially orienting responses to relevant stimuli. To define the stimulus with the highest priority at each moment, a network of reciprocal connections between the TeO and the isthmi promotes competition between concurrent tectal inputs. In the avian midbrain, the neurons mediating enhancement and suppression of tectal inputs are located in separate isthmic nuclei, facilitating the analysis of the neural processes that mediate competition. A specific subset of radial neurons in the intermediate tectal layers relay retinal inputs to the isthmi, but at present it is unclear whether separate neurons innervate individual nuclei or a single neural type sends a common input to several of them. In this study, we used in vitro neural tracing and cell-filling experiments in chickens to show that single neurons innervate, via axon collaterals, the three nuclei that comprise the isthmotectal network. This demonstrates that the input signals representing the strength of the incoming stimuli are simultaneously relayed to the mechanisms promoting both enhancement and suppression of the input signals. By performing in vivo recordings in anesthetized chicks, we also show that this common input generates synchrony between both antagonistic mechanisms, demonstrating that activity enhancement and suppression are closely coordinated. From a computational point of view, these results suggest that these tectal neurons constitute integrative nodes that combine inputs from different sources to drive in parallel several concurrent neural processes, each performing complementary functions within the network through different firing patterns and connectivity.","lang":"eng"}]}]