---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21453'
abstract:
- lang: eng
text: "1. Collective behaviours are a fascinating study area due to the emergent
properties that can only arise in groups of interacting individuals. However,
their quantitative study is often impaired by technical difficulties, creating
either low-quality and sparse data or impractical data amounts, particularly when
capturing large groups over long periods of time. Common challenges arise from
recording group members with as little obscuring of each other as possible, as
well as in generating manageable data amounts with as high as possible information
content.\r\n2. We here provide a multicomponent system that allows to record,
analyse and simulate the long-term spatiotemporal activity patterns of insect
collectives, especially ant colonies. Our Ant Observing System, ALTAA, comprises
a flat-nest design to prevent occlusion of individuals, a recording system running
on a low-power single-board-computer, and a set of computer programmes performing
quantitative analyses to guide the formation and validation of rules underlying
the observed collective patterns. Our system is scalable in that it allows parallel,
continuous observation of a high number of colonies using low memory space, with
colony maintenance requirements (e.g. feeding, nest humidity) being achieved at
lowest possible disturbance by the experimenter.\r\n3. We showcase the potential
of the system in a study using the black garden ant, Lasius niger, where we analyse
the spatiotemporal effects of different group sizes (1, 6, 10 ants), brood (larvae)
presence or absence, as well as of different nest geometries, over a period of
1 week. We show that the ants' motion activity has a weak periodicity in the range
of 20 to 120 min promoted by larval presence, and that ants are spatially attracted
to their larvae, the water source and the walls. We also find that the presence
of nestmates lowers an individual ant's motion activity. Observed data are compared
to simulations of the temporal activity of the ants.\r\n4. ALTAA provides a powerful
toolkit to quantify and interpret spatial and temporal collective activity patterns
in (social) insects over extended periods."
acknowledgement: We thank Harikrishnan Rajendran for discussion. This project has
received funding from the European Research Council (ERC) under the European Union's
Horizon 2020 Research and Innovation Programme (grant agreement No. 771402; EPIDEMICSonCHIP
to S.C.). Open Access funding provided by Institute of Science and Technology Austria/KEMÖ.
article_processing_charge: Yes
article_type: original
author:
- first_name: Jinook
full_name: Oh, Jinook
id: 403169A4-080F-11EA-9993-BF3F3DDC885E
last_name: Oh
orcid: 0000-0001-7425-2372
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: 'Oh J, Cremer S. ALTAA: Analysis of long-term activity patterns in ant colonies.
Methods in Ecology and Evolution. 2026. doi:10.1111/2041-210x.70277'
apa: 'Oh, J., & Cremer, S. (2026). ALTAA: Analysis of long-term activity patterns
in ant colonies. Methods in Ecology and Evolution. Wiley. https://doi.org/10.1111/2041-210x.70277'
chicago: 'Oh, Jinook, and Sylvia Cremer. “ALTAA: Analysis of Long-Term Activity
Patterns in Ant Colonies.” Methods in Ecology and Evolution. Wiley, 2026.
https://doi.org/10.1111/2041-210x.70277.'
ieee: 'J. Oh and S. Cremer, “ALTAA: Analysis of long-term activity patterns in ant
colonies,” Methods in Ecology and Evolution. Wiley, 2026.'
ista: 'Oh J, Cremer S. 2026. ALTAA: Analysis of long-term activity patterns in ant
colonies. Methods in Ecology and Evolution.'
mla: 'Oh, Jinook, and Sylvia Cremer. “ALTAA: Analysis of Long-Term Activity Patterns
in Ant Colonies.” Methods in Ecology and Evolution, Wiley, 2026, doi:10.1111/2041-210x.70277.'
short: J. Oh, S. Cremer, Methods in Ecology and Evolution (2026).
corr_author: '1'
date_created: 2026-03-15T23:01:36Z
date_published: 2026-03-06T00:00:00Z
date_updated: 2026-03-16T10:31:02Z
day: '06'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1111/2041-210x.70277
ec_funded: 1
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
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url: https://doi.org/10.1111/2041-210x.70277
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publication: Methods in Ecology and Evolution
publication_identifier:
eissn:
- 2041-210X
publication_status: epub_ahead
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'ALTAA: Analysis of long-term activity patterns in ant colonies'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
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...
---
OA_place: publisher
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_id: '21076'
abstract:
- lang: eng
text: In many scientific experiments, the data annotating cost constraints the pace
for testing novel hypotheses. Yet, modern machine learning pipelines offer a promising
solution—provided their predictions yield correct conclusions. We focus on Prediction-Powered
Causal Inferences (PPCI), i.e., estimating the treatment effect in an unlabeled
target experiment, relying on training data with the same outcome annotated but
potentially different treatment or effect modifiers. We first show that conditional
calibration guarantees valid PPCI at population level. Then, we introduce a sufficient
representation constraint transferring validity across experiments, which we propose
to enforce in practice in Deconfounded Empirical Risk Minimization, our new model-agnostic
training objective. We validate our method on synthetic and real-world scientific
data, solving impossible problem instances for Empirical Risk Minimization even
with standard invariance constraints. In particular, for the first time, we achieve
valid causal inference on a scientific experiment with complex recording and no
human annotations, fine-tuning a foundational model on our similar annotated experiment.
acknowledgement: We thank the Causal Learning and Artificial Intelligence group at
ISTA for the continuous feedback on the project and valuable discussions. We thank
the Social Immunity group at ISTA, particularly Jinook Oh, for the annotation program
and Michaela Hoenigsberger for supporting our ecological experiment. Riccardo Cadei
is supported by a Google Research Scholar Award and a Google Initiated Gift to Francesco
Locatello. This research was funded in part by the Austrian Science Fund (FWF) 10.55776/COE12).
It was further partially supported by the ISTA Interdisciplinary Project Committee
for the collaborative project “ALED” between Francesco Locatello and Sylvia Cremer.
For open access purposes, the author has applied a CC BY public copyright license
to any author accepted manuscript version arising from this submission.
alternative_title:
- Advances in Neural Information Processing Systems
article_processing_charge: No
author:
- first_name: Riccardo
full_name: Cadei, Riccardo
id: 0fa8b76f-72f0-11ef-b75a-a5da96e5ad6b
last_name: Cadei
- first_name: Ilker
full_name: Demirel, Ilker
last_name: Demirel
- first_name: Piersilvio
full_name: De Bartolomeis, Piersilvio
last_name: De Bartolomeis
- first_name: Lukas
full_name: Lindorfer, Lukas
id: 85f0e6d3-06b3-11ec-8982-8c5049fa4455
last_name: Lindorfer
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Cordelia
full_name: Schmid, Cordelia
last_name: Schmid
- first_name: Francesco
full_name: Locatello, Francesco
id: 26cfd52f-2483-11ee-8040-88983bcc06d4
last_name: Locatello
orcid: 0000-0002-4850-0683
citation:
ama: 'Cadei R, Demirel I, De Bartolomeis P, et al. Prediction-powered causal inferences.
In: 39th Annual Conference on Neural Information Processing Systems. Vol
38. Neural Information Processing Systems Foundation; 2025.'
apa: 'Cadei, R., Demirel, I., De Bartolomeis, P., Lindorfer, L., Cremer, S., Schmid,
C., & Locatello, F. (2025). Prediction-powered causal inferences. In 39th
Annual Conference on Neural Information Processing Systems (Vol. 38). San
Diego, CA, United States: Neural Information Processing Systems Foundation.'
chicago: Cadei, Riccardo, Ilker Demirel, Piersilvio De Bartolomeis, Lukas Lindorfer,
Sylvia Cremer, Cordelia Schmid, and Francesco Locatello. “Prediction-Powered Causal
Inferences.” In 39th Annual Conference on Neural Information Processing Systems,
Vol. 38. Neural Information Processing Systems Foundation, 2025.
ieee: R. Cadei et al., “Prediction-powered causal inferences,” in 39th
Annual Conference on Neural Information Processing Systems, San Diego, CA,
United States, 2025, vol. 38.
ista: 'Cadei R, Demirel I, De Bartolomeis P, Lindorfer L, Cremer S, Schmid C, Locatello
F. 2025. Prediction-powered causal inferences. 39th Annual Conference on Neural
Information Processing Systems. NeurIPS: Neural Information Processing Systems,
Advances in Neural Information Processing Systems, vol. 38.'
mla: Cadei, Riccardo, et al. “Prediction-Powered Causal Inferences.” 39th Annual
Conference on Neural Information Processing Systems, vol. 38, Neural Information
Processing Systems Foundation, 2025.
short: R. Cadei, I. Demirel, P. De Bartolomeis, L. Lindorfer, S. Cremer, C. Schmid,
F. Locatello, in:, 39th Annual Conference on Neural Information Processing Systems,
Neural Information Processing Systems Foundation, 2025.
conference:
end_date: 2025-12-07
location: San Diego, CA, United States
name: 'NeurIPS: Neural Information Processing Systems'
start_date: 2025-12-02
date_created: 2026-01-29T14:35:11Z
date_published: 2025-12-15T00:00:00Z
date_updated: 2026-02-16T11:39:33Z
day: '15'
ddc:
- '000'
department:
- _id: FrLo
- _id: SyCr
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oa: 1
oa_version: Published Version
publication: 39th Annual Conference on Neural Information Processing Systems
publication_identifier:
issn:
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publication_status: epub_ahead
publisher: Neural Information Processing Systems Foundation
quality_controlled: '1'
status: public
title: Prediction-powered causal inferences
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 38
year: '2025'
...
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APC_amount: 7068 EUR
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OA_place: publisher
OA_type: gold
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_id: '18892'
abstract:
- lang: eng
text: Sick individuals often conceal their disease status to group members, thereby
preventing social exclusion or aggression. Here we show by behavioural, chemical,
immunological and infection load analyses that sick ant pupae instead actively
emit a chemical signal that in itself is sufficient to trigger their own destruction
by colony members. In our experiments, this altruistic disease-signalling was
performed only by worker but not queen pupae. The lack of signalling by queen
pupae did not constitute cheating behaviour, but reflected their superior immune
capabilities. Worker pupae suffered from extensive pathogen replication whereas
queen pupae were able to restrain their infection. Our data suggest the evolution
of a finely-tuned signalling system in which it is not the induction of an individual’s
immune response, but rather its failure to overcome the infection, that triggers
pupal signalling for sacrifice. This demonstrates a balanced interplay between
individual and social immunity that efficiently achieves whole-colony health.
acknowledged_ssus:
- _id: LifeSc
- _id: MassSpec
acknowledgement: We thank Joergen Eilenberg and Nicolai V. Meyling for the fungal
strain, and the ISTA Social Immunity team, Jonghyun Park and Yuko Ulrich for ant
collection. We also thank the Social Immunity team, in particular David Moreno Martínez,
Tanvi Madaan, Wilfrid Jean Louis and Jessica Kirchner, for experimental and molecular
support, as well as Friedrich Fochler for technical support with the chemical analysis,
and the ISTA Lab Support Facility, including the mass spectrometry unit, for general
and chemical laboratory support. We further thank Marco Ribezzi for advice on 13C
calculations and Ernst Pittenauer for discussion of the chemical data, Chris Pull
and Michael Sixt for project discussion, and the Social Immunity team for comments
on the manuscript. The study was funded by the European Research Council (ERC) under
the European Union’s Horizon 2020 research and innovation Programme (No. 771402;
EPIDEMICSonCHIP) to SC.
article_number: '10511'
article_processing_charge: Yes
article_type: original
author:
- first_name: Erika
full_name: Dawson, Erika
id: 31B4E2D0-F248-11E8-B48F-1D18A9856A87
last_name: Dawson
- first_name: Michaela
full_name: Hönigsberger, Michaela
id: 953894f3-25bd-11ec-8556-f70a9d38ef60
last_name: Hönigsberger
- first_name: Niklas
full_name: Kampleitner, Niklas
id: 2AC57FAC-F248-11E8-B48F-1D18A9856A87
last_name: Kampleitner
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Lukas
full_name: Lindorfer, Lukas
id: 85f0e6d3-06b3-11ec-8982-8c5049fa4455
last_name: Lindorfer
- first_name: Jennifer
full_name: Robb, Jennifer
id: 7bc2734a-e2c6-11ea-9824-a2ed5f0662a8
last_name: Robb
- first_name: Farnaz
full_name: Beikzadeh Abbasi, Farnaz
id: 0344bfb9-3feb-11ee-87e9-c27edc800bcd
last_name: Beikzadeh Abbasi
- first_name: Florian
full_name: Strahodinsky, Florian
id: 979E35EE-C996-11E9-8C7C-CF13E6697425
last_name: Strahodinsky
- first_name: Hanna
full_name: Leitner, Hanna
id: 8fc5c6f6-5903-11ec-abad-c83f046253e7
last_name: Leitner
- first_name: Harikrishnan
full_name: Rajendran, Harikrishnan
id: 876b6b34-8ff4-11ec-97c9-8d95a7aae416
last_name: Rajendran
- first_name: Thomas
full_name: Schmitt, Thomas
last_name: Schmitt
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Dawson E, Hönigsberger M, Kampleitner N, et al. Altruistic disease signalling
in ant colonies. Nature Communications. 2025;16. doi:10.1038/s41467-025-66175-z
apa: Dawson, E., Hönigsberger, M., Kampleitner, N., Grasse, A. V., Lindorfer, L.,
Robb, J., … Cremer, S. (2025). Altruistic disease signalling in ant colonies.
Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-025-66175-z
chicago: Dawson, Erika, Michaela Hönigsberger, Niklas Kampleitner, Anna V Grasse,
Lukas Lindorfer, Jennifer Robb, Farnaz Beikzadeh, et al. “Altruistic Disease Signalling
in Ant Colonies.” Nature Communications. Springer Nature, 2025. https://doi.org/10.1038/s41467-025-66175-z.
ieee: E. Dawson et al., “Altruistic disease signalling in ant colonies,”
Nature Communications, vol. 16. Springer Nature, 2025.
ista: Dawson E, Hönigsberger M, Kampleitner N, Grasse AV, Lindorfer L, Robb J, Beikzadeh
F, Strahodinsky F, Leitner H, Rajendran H, Schmitt T, Cremer S. 2025. Altruistic
disease signalling in ant colonies. Nature Communications. 16, 10511.
mla: Dawson, Erika, et al. “Altruistic Disease Signalling in Ant Colonies.” Nature
Communications, vol. 16, 10511, Springer Nature, 2025, doi:10.1038/s41467-025-66175-z.
short: E. Dawson, M. Hönigsberger, N. Kampleitner, A.V. Grasse, L. Lindorfer, J.
Robb, F. Beikzadeh, F. Strahodinsky, H. Leitner, H. Rajendran, T. Schmitt, S.
Cremer, Nature Communications 16 (2025).
corr_author: '1'
date_created: 2025-01-27T11:28:05Z
date_published: 2025-12-01T00:00:00Z
date_updated: 2026-06-10T08:50:53Z
day: '01'
ddc:
- '570'
department:
- _id: SyCr
- _id: LifeSc
doi: 10.1038/s41467-025-66175-z
ec_funded: 1
external_id:
pmid:
- '41330896'
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call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
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title: Altruistic disease signalling in ant colonies
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
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type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
_id: '20471'
abstract:
- lang: eng
text: 'Sick individuals often conceal their disease status to group members, thereby
preventing social exclusion or aggression. Here we show by behavioural, chemical,
immunological and infection load analyses that sick ant pupae instead actively
emit a chemical signal that in itself is sufficient to trigger their own destruction
by colony members. In our experiments, this altruistic disease-signalling was
performed only by worker but not queen pupae. The lack of signalling by queen
pupae did not constitute cheating behaviour, but reflected their superior immune
capabilities. Worker pupae suffered from extensive pathogen replication whereas
queen pupae were able to restrain their infection. Our data suggest the evolution
of a finely-tuned signalling system in which it is not the induction of an individual’s
immune response, but rather its failure to overcome the infection, that triggers
pupal signalling for sacrifice. This demonstrates a balanced interplay between
individual and social immunity that efficiently achieves whole-colony health. '
acknowledgement: 'We thank Joergen Eilenberg and Nicolai V. Meyling for the fungal
strain, and the ISTA Social Immunity team, Jonghyun Park and Yuko Ulrich for ant
collection. We also thank the Social Immunity team, in particular David Moreno Martínez,
Tanvi Madaan, Wilfrid Jean Louis and Jessica Kirchner, for experimental and molecular
support, as well as Friedrich Fochler for technical support with the chemical analysis,
and the ISTA Lab Support Facility, including the mass spectrometry unit, for general
and chemical laboratory support. We further thank Marco Ribezzi for advice on 13C
calculations and Ernst Pittenauer for discussion of the chemical data, Chris Pull
and Michael Sixt for project discussion and the Social Immunity team for comments
on the manuscript. The study was funded by the European Research Council (ERC) under
the European Union’s Horizon 2020 research and innovation Programme (No. 771402;
EPIDEMICSonCHIP) to SC. '
article_processing_charge: No
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Cremer S. Altruistic disease signalling in ant colonies. 2025. doi:10.15479/AT-ISTA-20471
apa: Cremer, S. (2025). Altruistic disease signalling in ant colonies. Institute
of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20471
chicago: Cremer, Sylvia. “Altruistic Disease Signalling in Ant Colonies.” Institute
of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20471.
ieee: S. Cremer, “Altruistic disease signalling in ant colonies.” Institute of Science
and Technology Austria, 2025.
ista: Cremer S. 2025. Altruistic disease signalling in ant colonies, Institute of
Science and Technology Austria, 10.15479/AT-ISTA-20471.
mla: Cremer, Sylvia. Altruistic Disease Signalling in Ant Colonies. Institute
of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20471.
short: S. Cremer, (2025).
contributor:
- first_name: Erika
id: 31B4E2D0-F248-11E8-B48F-1D18A9856A87
last_name: Dawson
- first_name: Michaela
id: 953894f3-25bd-11ec-8556-f70a9d38ef60
last_name: Hönigsberger
- first_name: Niklas
id: 2AC57FAC-F248-11E8-B48F-1D18A9856A87
last_name: Kampleitner
- first_name: Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Lukas
id: 85f0e6d3-06b3-11ec-8982-8c5049fa4455
last_name: Lindorfer
- first_name: Jennifer
id: 7bc2734a-e2c6-11ea-9824-a2ed5f0662a8
last_name: Robb
- first_name: Farnaz
id: 0344bfb9-3feb-11ee-87e9-c27edc800bcd
last_name: Beikzadeh Abbasi
- first_name: Florian
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last_name: Strahodinsky
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last_name: Leitner
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id: 876b6b34-8ff4-11ec-97c9-8d95a7aae416
last_name: Rajendran
- first_name: Thomas
last_name: Schmitt
- first_name: Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
corr_author: '1'
date_created: 2025-10-16T09:02:16Z
date_published: 2025-10-16T00:00:00Z
date_updated: 2026-06-10T08:50:53Z
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ddc:
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keyword:
- host-parasite interactions
- social insects
- social immunity
- chemical communication
- cooperation
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '18892'
relation: used_in_publication
status: public
status: public
title: Altruistic disease signalling in ant colonies
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2025'
...
---
APC_amount: 3040,36 EUR
OA_place: publisher
OA_type: hybrid
_id: '14478'
abstract:
- lang: eng
text: Entire chromosomes are typically only transmitted vertically from one generation
to the next. The horizontal transfer of such chromosomes has long been considered
improbable, yet gained recent support in several pathogenic fungi where it may
affect the fitness or host specificity. To date, it is unknown how these transfers
occur, how common they are and whether they can occur between different species.
In this study, we show multiple independent instances of horizontal transfers
of the same accessory chromosome between two distinct strains of the asexual entomopathogenic
fungusMetarhizium robertsiiduring experimental co-infection
of its insect host, the Argentine ant. Notably, only the one chromosome – but
no other – was transferred from the donor to the recipient strain. The recipient
strain, now harboring the accessory chromosome, exhibited a competitive advantage
under certain host conditions. By phylogenetic analysis we further demonstrate
that the same accessory chromosome was horizontally transferred in a natural environment
betweenM. robertsiiand another congeneric insect pathogen,M.
guizhouense. Hence horizontal chromosome transfer is not limited
to the observed frequent events within species during experimental infections
but also occurs naturally across species. The transferred accessory chromosome
contains genes that might be involved in its preferential horizontal transfer,
encoding putative histones and histone-modifying enzymes, but also putative virulence
factors that may support its establishment. Our study reveals that both intra-
and interspecies horizontal transfer of entire chromosomes is more frequent than
previously assumed, likely representing a not uncommon mechanism for gene exchange.Significance
StatementThe enormous success of bacterial pathogens has
been attributed to their ability to exchange genetic material between one another.
Similarly, in eukaryotes, horizontal transfer of genetic material allowed the
spread of virulence factors across species. The horizontal transfer of whole chromosomes
could be an important pathway for such exchange of genetic material, but little
is known about the origin of transferable chromosomes and how frequently they
are exchanged. Here, we show that the transfer of accessory chromosomes - chromosomes
that are non-essential but may provide fitness benefits - is common during fungal
co-infections and is even possible between distant pathogenic species, highlighting
the importance of horizontal gene transfer via chromosome transfer also for the
evolution and function of eukaryotic pathogens.
acknowledgement: We thank Bernhardt Steinwender, Jorgen Eilenberg, and Nicolai V.
Meyling for the fungal strains. We further thank Chengshu Wang for providing the
short sequencing reads for M. guizhouense ARESF977 he used for his published genome
assembly, and Kristian Ullrich for help in the bioinformatics analysis for methylation
pattern in Nanopore reads, and the VBC and the Max Planck Society for the use of
their sequencing centers. We thank Barbara Milutinović and Hinrich Schulenburg for
discussion, and Tal Dagan and Jens Rolff for comments on a previous version of the
manuscript. Fig. 1A was created with BioRender.com. This study received funding
by the European Research Council under the European Union’s Horizon 2020 Research
and Innovation Programme (No. 771402; EPIDEMICSonCHIP) to S.C. and by the German
Research Foundation (DFG grant HA9263/1-1) to M.H.
article_number: e2316284121
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Michael
full_name: Habig, Michael
last_name: Habig
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Judith
full_name: Müller, Judith
last_name: Müller
- first_name: Eva H.
full_name: Stukenbrock, Eva H.
last_name: Stukenbrock
- first_name: Hanna
full_name: Leitner, Hanna
id: 8fc5c6f6-5903-11ec-abad-c83f046253e7
last_name: Leitner
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. Frequent
horizontal chromosome transfer between asexual fungal insect pathogens. Proceedings
of the National Academy of Sciences of the United States of America. 2024;121(11).
doi:10.1073/pnas.2316284121
apa: Habig, M., Grasse, A. V., Müller, J., Stukenbrock, E. H., Leitner, H., &
Cremer, S. (2024). Frequent horizontal chromosome transfer between asexual fungal
insect pathogens. Proceedings of the National Academy of Sciences of the United
States of America. National Academy of Sciences. https://doi.org/10.1073/pnas.2316284121
chicago: Habig, Michael, Anna V Grasse, Judith Müller, Eva H. Stukenbrock, Hanna
Leitner, and Sylvia Cremer. “Frequent Horizontal Chromosome Transfer between Asexual
Fungal Insect Pathogens.” Proceedings of the National Academy of Sciences of
the United States of America. National Academy of Sciences, 2024. https://doi.org/10.1073/pnas.2316284121.
ieee: M. Habig, A. V. Grasse, J. Müller, E. H. Stukenbrock, H. Leitner, and S. Cremer,
“Frequent horizontal chromosome transfer between asexual fungal insect pathogens,”
Proceedings of the National Academy of Sciences of the United States of America,
vol. 121, no. 11. National Academy of Sciences, 2024.
ista: Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. 2024. Frequent
horizontal chromosome transfer between asexual fungal insect pathogens. Proceedings
of the National Academy of Sciences of the United States of America. 121(11),
e2316284121.
mla: Habig, Michael, et al. “Frequent Horizontal Chromosome Transfer between Asexual
Fungal Insect Pathogens.” Proceedings of the National Academy of Sciences of
the United States of America, vol. 121, no. 11, e2316284121, National Academy
of Sciences, 2024, doi:10.1073/pnas.2316284121.
short: M. Habig, A.V. Grasse, J. Müller, E.H. Stukenbrock, H. Leitner, S. Cremer,
Proceedings of the National Academy of Sciences of the United States of America
121 (2024).
corr_author: '1'
date_created: 2023-10-31T13:30:00Z
date_published: 2024-03-12T00:00:00Z
date_updated: 2025-08-05T13:30:51Z
day: '12'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1073/pnas.2316284121
ec_funded: 1
external_id:
isi:
- '001207630200005'
pmid:
- '38442176'
file:
- access_level: open_access
checksum: f5e871db617b682edc71fcd08670dc81
content_type: application/pdf
creator: dernst
date_created: 2024-03-19T09:02:57Z
date_updated: 2024-03-19T09:02:57Z
file_id: '15124'
file_name: 2024_PNAS_Habig.pdf
file_size: 5750361
relation: main_file
success: 1
file_date_updated: 2024-03-19T09:02:57Z
has_accepted_license: '1'
intvolume: ' 121'
isi: 1
issue: '11'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Frequent horizontal chromosome transfer between asexual fungal insect pathogens
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 121
year: '2024'
...
---
_id: '14479'
abstract:
- lang: eng
text: 'In animals, parasitic infections impose significant fitness costs.1,2,3,4,5,6
Infected animals can alter their feeding behavior to resist infection,7,8,9,10,11,12
but parasites can manipulate animal foraging behavior to their own benefits.13,14,15,16
How nutrition influences host-parasite interactions is not well understood, as
studies have mainly focused on the host and less on the parasite.9,12,17,18,19,20,21,22,23
We used the nutritional geometry framework24 to investigate the role of amino
acids (AA) and carbohydrates (C) in a host-parasite system: the Argentine ant,
Linepithema humile, and the entomopathogenic fungus, Metarhizium brunneum. First,
using 18 diets varying in AA:C composition, we established that the fungus performed
best on the high-amino-acid diet 1:4. Second, we found that the fungus reached
this optimal diet when given various diet pairings, revealing its ability to cope
with nutritional challenges. Third, we showed that the optimal fungal diet reduced
the lifespan of healthy ants when compared with a high-carbohydrate diet but had
no effect on infected ants. Fourth, we revealed that infected ant colonies, given
a choice between the optimal fungal diet and a high-carbohydrate diet, chose the
optimal fungal diet, whereas healthy colonies avoided it. Lastly, by disentangling
fungal infection from host immune response, we demonstrated that infected ants
foraged on the optimal fungal diet in response to immune activation and not as
a result of parasite manipulation. Therefore, we revealed that infected ant colonies
chose a diet that is costly for survival in the long term but beneficial in the
short term—a form of collective self-medication.'
acknowledgement: We are sincerely grateful to the referees for their valuable comments
and suggestions, which helped us to improve the paper. We are thankful to Jorgen
Eilenberg and Nicolai V. Meyling for the fungal strain, to Simon Tragust, Abel Bernadou,
and Brian Lazarro for insightful discussions, to Iago Sanmartín-Villar, Léa Briard,
Céline Maitrel, and Nolwenn Rissen for their help with the experiments. Furthermore,
we thank Anna V. Grasse for help with the immune gene expression analyses. We thank
Sergio Ibarra for creating the graphical abstract. E.C. was supported by a Fyssen
Foundation grant and the Alexander von Humboldt Foundation. A.D. was supported by
the CNRS.
article_processing_charge: No
article_type: original
author:
- first_name: Eniko
full_name: Csata, Eniko
last_name: Csata
- first_name: Alfonso
full_name: Perez-Escudero, Alfonso
last_name: Perez-Escudero
- first_name: Emmanuel
full_name: Laury, Emmanuel
last_name: Laury
- first_name: Hanna
full_name: Leitner, Hanna
id: 8fc5c6f6-5903-11ec-abad-c83f046253e7
last_name: Leitner
- first_name: Gerard
full_name: Latil, Gerard
last_name: Latil
- first_name: Juerge
full_name: Heinze, Juerge
last_name: Heinze
- first_name: Stephen
full_name: Simpson, Stephen
last_name: Simpson
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Audrey
full_name: Dussutour, Audrey
last_name: Dussutour
citation:
ama: Csata E, Perez-Escudero A, Laury E, et al. Fungal infection alters collective
nutritional intake of ant colonies. Current Biology. 2024;34(4):902-909.e6.
doi:10.1016/j.cub.2024.01.017
apa: Csata, E., Perez-Escudero, A., Laury, E., Leitner, H., Latil, G., Heinze, J.,
… Dussutour, A. (2024). Fungal infection alters collective nutritional intake
of ant colonies. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2024.01.017
chicago: Csata, Eniko, Alfonso Perez-Escudero, Emmanuel Laury, Hanna Leitner, Gerard
Latil, Juerge Heinze, Stephen Simpson, Sylvia Cremer, and Audrey Dussutour. “Fungal
Infection Alters Collective Nutritional Intake of Ant Colonies.” Current Biology.
Elsevier, 2024. https://doi.org/10.1016/j.cub.2024.01.017.
ieee: E. Csata et al., “Fungal infection alters collective nutritional intake
of ant colonies,” Current Biology, vol. 34, no. 4. Elsevier, p. 902–909.e6,
2024.
ista: Csata E, Perez-Escudero A, Laury E, Leitner H, Latil G, Heinze J, Simpson
S, Cremer S, Dussutour A. 2024. Fungal infection alters collective nutritional
intake of ant colonies. Current Biology. 34(4), 902–909.e6.
mla: Csata, Eniko, et al. “Fungal Infection Alters Collective Nutritional Intake
of Ant Colonies.” Current Biology, vol. 34, no. 4, Elsevier, 2024, p. 902–909.e6,
doi:10.1016/j.cub.2024.01.017.
short: E. Csata, A. Perez-Escudero, E. Laury, H. Leitner, G. Latil, J. Heinze, S.
Simpson, S. Cremer, A. Dussutour, Current Biology 34 (2024) 902–909.e6.
date_created: 2023-10-31T13:30:20Z
date_published: 2024-02-26T00:00:00Z
date_updated: 2025-08-05T13:29:38Z
day: '26'
department:
- _id: SyCr
doi: 10.1016/j.cub.2024.01.017
external_id:
isi:
- '001195884300001'
pmid:
- '38307022'
intvolume: ' 34'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2023.10.26.564092
month: '02'
oa: 1
oa_version: Preprint
page: 902-909.e6
pmid: 1
publication: Current Biology
publication_identifier:
eissn:
- 1879-0445
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fungal infection alters collective nutritional intake of ant colonies
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2024'
...
---
OA_place: publisher
OA_type: gold
_id: '18847'
abstract:
- lang: eng
text: "Machine Learning and AI have the potential to transform data-driven\r\nscientific
discovery, enabling accurate predictions for several scientific\r\nphenomena.
As many scientific questions are inherently causal, this paper looks\r\nat the
causal inference task of treatment effect estimation, where the outcome\r\nof
interest is recorded in high-dimensional observations in a Randomized\r\nControlled
Trial (RCT). Despite being the simplest possible causal setting and\r\na perfect
fit for deep learning, we theoretically find that many common choices\r\nin the
literature may lead to biased estimates. To test the practical impact of\r\nthese
considerations, we recorded ISTAnt, the first real-world benchmark for\r\ncausal
inference downstream tasks on high-dimensional observations as an RCT\r\nstudying
how garden ants (Lasius neglectus) respond to microparticles applied\r\nonto their
colony members by hygienic grooming. Comparing 6 480 models\r\nfine-tuned from
state-of-the-art visual backbones, we find that the sampling\r\nand modeling choices
significantly affect the accuracy of the causal estimate,\r\nand that classification
accuracy is not a proxy thereof. We further validated\r\nthe analysis, repeating
it on a synthetically generated visual data set\r\ncontrolling the causal model.
Our results suggest that future benchmarks should\r\ncarefully consider real downstream
scientific questions, especially causal\r\nones. Further, we highlight guidelines
for representation learning methods to\r\nhelp answer causal questions in the
sciences."
acknowledgement: We thank Piersilvio De Bartolomeis, and the full Causal Learning
and Artificial Intelligence (CLAI) group at ISTA for the extremely helpful discussions.
Riccardo Cadei was supported by a Google Research Scholar Award and a Google Initiated
Gift to Francesco Locatello. We thank the Social Immunity team at ISTA particularly
Michaela Hönigsberger and Wilfrid Jean Louis, for supporting the ecological experiment
and Farnaz Beikzadeh Abbasi, Luisa Fiebig and Martin Estermann for annotating ant
behavior in ISTAnt.
article_processing_charge: No
arxiv: 1
author:
- first_name: Riccardo
full_name: Cadei, Riccardo
id: 0fa8b76f-72f0-11ef-b75a-a5da96e5ad6b
last_name: Cadei
- first_name: Lukas
full_name: Lindorfer, Lukas
id: 85f0e6d3-06b3-11ec-8982-8c5049fa4455
last_name: Lindorfer
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Cordelia
full_name: Schmid, Cordelia
last_name: Schmid
- first_name: Francesco
full_name: Locatello, Francesco
id: 26cfd52f-2483-11ee-8040-88983bcc06d4
last_name: Locatello
orcid: 0000-0002-4850-0683
citation:
ama: 'Cadei R, Lindorfer L, Cremer S, Schmid C, Locatello F. Smoke and mirrors in
causal downstream tasks. In: ICML 2024 Workshop AI4Science. Vol 38. Curran
Associates; 2024.'
apa: Cadei, R., Lindorfer, L., Cremer, S., Schmid, C., & Locatello, F. (2024).
Smoke and mirrors in causal downstream tasks. In ICML 2024 Workshop AI4Science
(Vol. 38). Curran Associates.
chicago: Cadei, Riccardo, Lukas Lindorfer, Sylvia Cremer, Cordelia Schmid, and Francesco
Locatello. “Smoke and Mirrors in Causal Downstream Tasks.” In ICML 2024 Workshop
AI4Science, Vol. 38. Curran Associates, 2024.
ieee: R. Cadei, L. Lindorfer, S. Cremer, C. Schmid, and F. Locatello, “Smoke and
mirrors in causal downstream tasks,” in ICML 2024 Workshop AI4Science,
2024, vol. 38.
ista: 'Cadei R, Lindorfer L, Cremer S, Schmid C, Locatello F. 2024. Smoke and mirrors
in causal downstream tasks. ICML 2024 Workshop AI4Science. ICML: International
Conference on Machine Learning vol. 38.'
mla: Cadei, Riccardo, et al. “Smoke and Mirrors in Causal Downstream Tasks.” ICML
2024 Workshop AI4Science, vol. 38, Curran Associates, 2024.
short: R. Cadei, L. Lindorfer, S. Cremer, C. Schmid, F. Locatello, in:, ICML 2024
Workshop AI4Science, Curran Associates, 2024.
conference:
end_date: 2024-07-26
name: 'ICML: International Conference on Machine Learning'
start_date: 2024-07-26
corr_author: '1'
date_created: 2025-01-14T07:27:26Z
date_published: 2024-09-25T00:00:00Z
date_updated: 2025-07-10T11:51:50Z
day: '25'
ddc:
- '000'
- '570'
department:
- _id: SyCr
- _id: FrLo
- _id: GradSch
external_id:
arxiv:
- '2405.17151'
file:
- access_level: open_access
checksum: beedf05388bbdb7ddda81ec3d5ec7026
content_type: application/pdf
creator: dernst
date_created: 2025-01-27T11:42:24Z
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month: '09'
oa: 1
oa_version: Published Version
publication: ICML 2024 Workshop AI4Science
publication_status: published
publisher: Curran Associates
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/CausalLearningAI/ISTAnt
record:
- id: '18895'
relation: research_data
status: public
- id: '19509'
relation: is_continued_by
status: for_moderation
scopus_import: '1'
status: public
title: Smoke and mirrors in causal downstream tasks
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 38
year: '2024'
...
---
OA_place: repository
OA_type: gold
_id: '18895'
abstract:
- lang: eng
text: 'ISTAnt is a new ecological dataset for social immunity and represents the
first real-world benchmark for causal inference downstream tasks on high-dimensional
observations. It analyzes grooming behavior in the ant Lasius neglectus in groups
of three worker ants. The workers for the experiment were obtained from their
laboratory stock colony, which had been collected from the field in 2022 in the
Botanical Garden Jena, Germany. Ant collection and all experimental work were
performed in compliance with international, national and institutional regulations
and ethical guidelines. For the experiment, the body surface of one of the three
ants was treated with a suspension of either of two microparticle types (diameter
~5 µm) to induce grooming by the two nestmates, which were individually color-coded
by application of a dot of blue or orange paint, respectively. The three ants
were housed in small plastic containers (diameter 28mm, height 30mm) with moistened,
plastered ground and the interior walls covered with PTFE (polytetrafluoroethane)
to hamper climbing by the ants. Filming occurred in a temperature- and humidity-controlled
room at 23°C within a custom-made filming box with controlled lighting and ventilation
conditions. We set up nine ant groups at a time (always containing both treatments)
and placed them randomly on positions 1-9 marked on the floor in a 3x3 grid, about
3mm from each other. The experiment was performed on two consecutive days. Videos
were acquired using a USB camera (FLIR blackfly S BFS-U3-120S4C, Teledyne FLIR)
with a high-performance lens (HP Series 25mm Focal Length, Edmund optics 86-572)
in OBS studio 29.0.0 \citep{bailey2017obs} at a framerate of 30 FPS and a resolution
of 2500x2500 pixels. From each original video (105x105 mm), we generated nine
individual videos .mkv (each ~32x32 mm, 770x770 pixels) by determining exact coordinates
per container from one frame in GIMP 2.10.36 and cropping of the videos with FFmpeg
6.1.1. Annotation was performed over two consecutive days by three observers who
had not been involved in the experimental setup or recording and were unaware
of the treatment assignments to ensure bias-free behavioral annotation. They annotated
the behavior of the ants during video observations, using custom-made software
that saves the start and end frames of behaviors marked in a .csv file (see ''annotations''
folder). In one of the videos, one of the nestmates'' legs got inadvertently stuck
to its body surface during the color-coding, interfering with its behavior, so
the video was discarded. This left 44 videos from 5 independent setups (n=24 of
treatment 1 and n=20 of treatment 2) of 10 minutes each for a total of 792 000
annotated frames (see ''video'' folder). For each video, we provide the following
information: the number of the set to which it belongs (1-5); the number of the
position within the set reflecting the position of the ant group under the camera
(1-9), for which we also provide ‘coordinates’ in the 3x3 grid (taking values
-1/0/1 for both X and Y axis); treatment (1 or 2); the hour of the day when the
recording was started (in 24h CEST); experimental day (A or B); the top left coordinate
of the cropping square from the original video (CropX/CropY); the person annotating
the video (given as A, B, C); the date of annotation (1: first day, 2: second
day) and in which order the videos were annotated by each person, both reflecting
a possible training effect of the person (see ''experiments_settings.csv'' file).'
article_processing_charge: No
author:
- first_name: Riccardo
full_name: Cadei, Riccardo
id: 0fa8b76f-72f0-11ef-b75a-a5da96e5ad6b
last_name: Cadei
- first_name: Francesco
full_name: Locatello, Francesco
id: 26cfd52f-2483-11ee-8040-88983bcc06d4
last_name: Locatello
orcid: 0000-0002-4850-0683
- first_name: Sylvia M
full_name: Cremer, Sylvia M
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Lukas
full_name: Lindorfer, Lukas
id: 85f0e6d3-06b3-11ec-8982-8c5049fa4455
last_name: Lindorfer
- first_name: Cordelia
full_name: Schmid, Cordelia
last_name: Schmid
citation:
ama: Cadei R, Locatello F, Cremer S, Lindorfer L, Schmid C. ISTAnt. 2024. doi:10.6084/M9.FIGSHARE.26484934.V2
apa: Cadei, R., Locatello, F., Cremer, S., Lindorfer, L., & Schmid, C. (2024).
ISTAnt. Institute of Science and Technology Austria. https://doi.org/10.6084/M9.FIGSHARE.26484934.V2
chicago: Cadei, Riccardo, Francesco Locatello, Sylvia Cremer, Lukas Lindorfer, and
Cordelia Schmid. “ISTAnt.” Institute of Science and Technology Austria, 2024.
https://doi.org/10.6084/M9.FIGSHARE.26484934.V2.
ieee: R. Cadei, F. Locatello, S. Cremer, L. Lindorfer, and C. Schmid, “ISTAnt.”
Institute of Science and Technology Austria, 2024.
ista: Cadei R, Locatello F, Cremer S, Lindorfer L, Schmid C. 2024. ISTAnt, Institute
of Science and Technology Austria, 10.6084/M9.FIGSHARE.26484934.V2.
mla: Cadei, Riccardo, et al. ISTAnt. Institute of Science and Technology
Austria, 2024, doi:10.6084/M9.FIGSHARE.26484934.V2.
short: R. Cadei, F. Locatello, S. Cremer, L. Lindorfer, C. Schmid, (2024).
corr_author: '1'
date_created: 2025-01-27T11:45:43Z
date_published: 2024-10-23T00:00:00Z
date_updated: 2025-01-27T11:58:38Z
day: '23'
ddc:
- '570'
department:
- _id: SyCr
- _id: FrLo
- _id: GradSch
doi: 10.6084/M9.FIGSHARE.26484934.V2
main_file_link:
- open_access: '1'
url: https://10.6084/M9.FIGSHARE.26484934.V2
month: '10'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '18847'
relation: used_in_publication
status: public
status: public
title: ISTAnt
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...
---
OA_place: publisher
OA_type: hybrid
_id: '17461'
abstract:
- lang: eng
text: Socially living animals can counteract disease through cooperative defences,
leading to social immunity that collectively exceeds the sum of individual defences.
In superorganismal colonies of social insects with permanent caste separation
between reproductive queen(s) and nonreproducing workers, workers are obligate
altruists and thus engage in unconditional social immunity, including highly specialised
and self-sacrificial hygiene behaviours. Contrastingly, cooperation is facultative
in cooperatively breeding families, where all members are reproductively totipotent
but offspring transiently forgo reproduction to help their parents rear more siblings.
Here, helpers should either express condition-dependent social immunity or disperse
to pursue independent reproduction. We advocate inclusive fitness theory as a
framework to predict when and how indirect fitness gains may outweigh direct fitness
costs, thus favouring conditional social immunity.
acknowledgement: We thank Koos Boomsma and two anonymous reviewers for their constructive
comments on the manuscript.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Christopher
full_name: Pull, Christopher
id: 3C7F4840-F248-11E8-B48F-1D18A9856A87
last_name: Pull
orcid: 0000-0003-1122-3982
citation:
ama: Cremer S, Pull C. Unconditional versus condition-dependent social immunity.
Trends in Parasitology. 2024;40(9):780-787. doi:10.1016/j.pt.2024.07.014
apa: Cremer, S., & Pull, C. (2024). Unconditional versus condition-dependent
social immunity. Trends in Parasitology. Elsevier. https://doi.org/10.1016/j.pt.2024.07.014
chicago: Cremer, Sylvia, and Christopher Pull. “Unconditional versus Condition-Dependent
Social Immunity.” Trends in Parasitology. Elsevier, 2024. https://doi.org/10.1016/j.pt.2024.07.014.
ieee: S. Cremer and C. Pull, “Unconditional versus condition-dependent social immunity,”
Trends in Parasitology, vol. 40, no. 9. Elsevier, pp. 780–787, 2024.
ista: Cremer S, Pull C. 2024. Unconditional versus condition-dependent social immunity.
Trends in Parasitology. 40(9), 780–787.
mla: Cremer, Sylvia, and Christopher Pull. “Unconditional versus Condition-Dependent
Social Immunity.” Trends in Parasitology, vol. 40, no. 9, Elsevier, 2024,
pp. 780–87, doi:10.1016/j.pt.2024.07.014.
short: S. Cremer, C. Pull, Trends in Parasitology 40 (2024) 780–787.
corr_author: '1'
date_created: 2024-08-25T22:01:08Z
date_published: 2024-09-01T00:00:00Z
date_updated: 2025-09-08T09:01:42Z
day: '01'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1016/j.pt.2024.07.014
external_id:
isi:
- '001307815700001'
pmid:
- '39152078'
file:
- access_level: open_access
checksum: 362fc994e5df66caf3025b7dc437b647
content_type: application/pdf
creator: dernst
date_created: 2025-01-09T13:46:05Z
date_updated: 2025-01-09T13:46:05Z
file_id: '18816'
file_name: 2024_TrendsParasitology_Cremer.pdf
file_size: 1068464
relation: main_file
success: 1
file_date_updated: 2025-01-09T13:46:05Z
has_accepted_license: '1'
intvolume: ' 40'
isi: 1
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 780-787
pmid: 1
publication: Trends in Parasitology
publication_identifier:
eissn:
- 1471-5007
issn:
- 1471-4922
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unconditional versus condition-dependent social immunity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 40
year: '2024'
...
---
_id: '12469'
abstract:
- lang: eng
text: 'Hosts can carry many viruses in their bodies, but not all of them cause disease.
We studied ants as a social host to determine both their overall viral repertoire
and the subset of actively infecting viruses across natural populations of three
subfamilies: the Argentine ant (Linepithema humile, Dolichoderinae), the invasive
garden ant (Lasius neglectus, Formicinae) and the red ant (Myrmica rubra, Myrmicinae).
We used a dual sequencing strategy to reconstruct complete virus genomes by RNA-seq
and to simultaneously determine the small interfering RNAs (siRNAs) by small RNA
sequencing (sRNA-seq), which constitute the host antiviral RNAi immune response.
This approach led to the discovery of 41 novel viruses in ants and revealed a
host ant-specific RNAi response (21 vs. 22 nt siRNAs) in the different ant species.
The efficiency of the RNAi response (sRNA/RNA read count ratio) depended on the
virus and the respective ant species, but not its population. Overall, we found
the highest virus abundance and diversity per population in Li. humile, followed
by La. neglectus and M. rubra. Argentine ants also shared a high proportion of
viruses between populations, whilst overlap was nearly absent in M. rubra. Only
one of the 59 viruses was found to infect two of the ant species as hosts, revealing
high host-specificity in active infections. In contrast, six viruses actively
infected one ant species, but were found as contaminants only in the others. Disentangling
spillover of disease-causing infection from non-infecting contamination across
species is providing relevant information for disease ecology and ecosystem management.'
acknowledgement: "We thank D.J. Obbard for sharing the details of the dual RNA-seq/sRNA-seq
approach, S.\r\nMetzler and R. Ferrigato for the photographs (Figure 1), M. Konrad,
B. Casillas-Perez, C.D.\r\nPull and X. Espadaler for help with ant collection, and
the Social Immunity Team at IST\r\nAustria, in particular J. Robb, A. Franschitz,
E. Naderlinger, E. Dawson and B. Casillas-Perez\r\nfor support and comments on the
manuscript. The study was funded by the Austrian Science\r\nFund (FWF; M02076-B25
to MAF) and the Academy of Finland (343022 to LV). "
article_number: '1119002'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Lumi
full_name: Viljakainen, Lumi
last_name: Viljakainen
- first_name: Matthias
full_name: Fürst, Matthias
id: 393B1196-F248-11E8-B48F-1D18A9856A87
last_name: Fürst
orcid: 0000-0002-3712-925X
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Jaana
full_name: Jurvansuu, Jaana
last_name: Jurvansuu
- first_name: Jinook
full_name: Oh, Jinook
id: 403169A4-080F-11EA-9993-BF3F3DDC885E
last_name: Oh
orcid: 0000-0001-7425-2372
- first_name: Lassi
full_name: Tolonen, Lassi
last_name: Tolonen
- first_name: Thomas
full_name: Eder, Thomas
last_name: Eder
- first_name: Thomas
full_name: Rattei, Thomas
last_name: Rattei
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Viljakainen L, Fürst M, Grasse AV, et al. Antiviral immune response reveals
host-specific virus infections in natural ant populations. Frontiers in Microbiology.
2023;14. doi:10.3389/fmicb.2023.1119002
apa: Viljakainen, L., Fürst, M., Grasse, A. V., Jurvansuu, J., Oh, J., Tolonen,
L., … Cremer, S. (2023). Antiviral immune response reveals host-specific virus
infections in natural ant populations. Frontiers in Microbiology. Frontiers.
https://doi.org/10.3389/fmicb.2023.1119002
chicago: Viljakainen, Lumi, Matthias Fürst, Anna V Grasse, Jaana Jurvansuu, Jinook
Oh, Lassi Tolonen, Thomas Eder, Thomas Rattei, and Sylvia Cremer. “Antiviral Immune
Response Reveals Host-Specific Virus Infections in Natural Ant Populations.” Frontiers
in Microbiology. Frontiers, 2023. https://doi.org/10.3389/fmicb.2023.1119002.
ieee: L. Viljakainen et al., “Antiviral immune response reveals host-specific
virus infections in natural ant populations,” Frontiers in Microbiology,
vol. 14. Frontiers, 2023.
ista: Viljakainen L, Fürst M, Grasse AV, Jurvansuu J, Oh J, Tolonen L, Eder T, Rattei
T, Cremer S. 2023. Antiviral immune response reveals host-specific virus infections
in natural ant populations. Frontiers in Microbiology. 14, 1119002.
mla: Viljakainen, Lumi, et al. “Antiviral Immune Response Reveals Host-Specific
Virus Infections in Natural Ant Populations.” Frontiers in Microbiology,
vol. 14, 1119002, Frontiers, 2023, doi:10.3389/fmicb.2023.1119002.
short: L. Viljakainen, M. Fürst, A.V. Grasse, J. Jurvansuu, J. Oh, L. Tolonen, T.
Eder, T. Rattei, S. Cremer, Frontiers in Microbiology 14 (2023).
corr_author: '1'
date_created: 2023-01-31T08:13:40Z
date_published: 2023-03-16T00:00:00Z
date_updated: 2025-04-23T08:54:27Z
day: '16'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.3389/fmicb.2023.1119002
external_id:
isi:
- '000961542100001'
pmid:
- '37007485'
file:
- access_level: open_access
checksum: cd52292963acce1111634d9fac08c699
content_type: application/pdf
creator: dernst
date_created: 2023-04-17T07:49:09Z
date_updated: 2023-04-17T07:49:09Z
file_id: '12843'
file_name: 2023_FrontMicrobiology_Viljakainen.pdf
file_size: 4866332
relation: main_file
success: 1
file_date_updated: 2023-04-17T07:49:09Z
has_accepted_license: '1'
intvolume: ' 14'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25DF61D8-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02076
name: Viral pathogens and social immunity in ants
publication: Frontiers in Microbiology
publication_identifier:
eissn:
- 1664-302X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Antiviral immune response reveals host-specific virus infections in natural
ant populations
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2023'
...
---
_id: '12543'
abstract:
- lang: eng
text: Treating sick group members is a hallmark of collective disease defence in
vertebrates and invertebrates alike. Despite substantial effects on pathogen fitness
and epidemiology, it is still largely unknown how pathogens react to the selection
pressure imposed by care intervention. Using social insects and pathogenic fungi,
we here performed a serial passage experiment in the presence or absence of colony
members, which provide social immunity by grooming off infectious spores from
exposed individuals. We found specific effects on pathogen diversity, virulence
and transmission. Under selection of social immunity, pathogens invested into
higher spore production, but spores were less virulent. Notably, they also elicited
a lower grooming response in colony members, compared with spores from the individual
host selection lines. Chemical spore analysis suggested that the spores from social
selection lines escaped the caregivers’ detection by containing lower levels of
ergosterol, a key fungal membrane component. Experimental application of chemically
pure ergosterol indeed induced sanitary grooming, supporting its role as a microbe-associated
cue triggering host social immunity against fungal pathogens. By reducing this
detection cue, pathogens were able to evade the otherwise very effective collective
disease defences of their social hosts.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: We thank B. M. Steinwender, N. V. Meyling and J. Eilenberg for the
fungal strains; J. Anaya-Rojas for statistical advice; the Social Immunity team
at ISTA for ant collection and experimental help, in particular H. Leitner, and
the ISTA Lab Support Facility for general laboratory support; D. Ebert, H. Schulenburg
and J. Heinze for continued project discussion; and M. Sixt, R. Roemhild and the
Social Immunity team for comments on the manuscript. The study was funded by the
German Research Foundation (CR118/3-1) within the Framework of the Priority Program
SPP 1399, and the European Research Council (ERC) under the European Union’s Horizon
2020 Research and Innovation Programme (No. 771402; EPIDEMICSonCHIP), both to S.C.
article_processing_charge: No
article_type: original
author:
- first_name: Miriam
full_name: Stock, Miriam
id: 42462816-F248-11E8-B48F-1D18A9856A87
last_name: Stock
- first_name: Barbara
full_name: Milutinovic, Barbara
id: 2CDC32B8-F248-11E8-B48F-1D18A9856A87
last_name: Milutinovic
orcid: 0000-0002-8214-4758
- first_name: Michaela
full_name: Hönigsberger, Michaela
id: 953894f3-25bd-11ec-8556-f70a9d38ef60
last_name: Hönigsberger
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Florian
full_name: Wiesenhofer, Florian
id: 39523C54-F248-11E8-B48F-1D18A9856A87
last_name: Wiesenhofer
- first_name: Niklas
full_name: Kampleitner, Niklas
id: 2AC57FAC-F248-11E8-B48F-1D18A9856A87
last_name: Kampleitner
- first_name: Madhumitha
full_name: Narasimhan, Madhumitha
id: 44BF24D0-F248-11E8-B48F-1D18A9856A87
last_name: Narasimhan
orcid: 0000-0002-8600-0671
- first_name: Thomas
full_name: Schmitt, Thomas
last_name: Schmitt
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Stock M, Milutinovic B, Hönigsberger M, et al. Pathogen evasion of social immunity.
Nature Ecology and Evolution. 2023;7:450-460. doi:10.1038/s41559-023-01981-6
apa: Stock, M., Milutinovic, B., Hönigsberger, M., Grasse, A. V., Wiesenhofer, F.,
Kampleitner, N., … Cremer, S. (2023). Pathogen evasion of social immunity. Nature
Ecology and Evolution. Springer Nature. https://doi.org/10.1038/s41559-023-01981-6
chicago: Stock, Miriam, Barbara Milutinovic, Michaela Hönigsberger, Anna V Grasse,
Florian Wiesenhofer, Niklas Kampleitner, Madhumitha Narasimhan, Thomas Schmitt,
and Sylvia Cremer. “Pathogen Evasion of Social Immunity.” Nature Ecology and
Evolution. Springer Nature, 2023. https://doi.org/10.1038/s41559-023-01981-6.
ieee: M. Stock et al., “Pathogen evasion of social immunity,” Nature Ecology
and Evolution, vol. 7. Springer Nature, pp. 450–460, 2023.
ista: Stock M, Milutinovic B, Hönigsberger M, Grasse AV, Wiesenhofer F, Kampleitner
N, Narasimhan M, Schmitt T, Cremer S. 2023. Pathogen evasion of social immunity.
Nature Ecology and Evolution. 7, 450–460.
mla: Stock, Miriam, et al. “Pathogen Evasion of Social Immunity.” Nature Ecology
and Evolution, vol. 7, Springer Nature, 2023, pp. 450–60, doi:10.1038/s41559-023-01981-6.
short: M. Stock, B. Milutinovic, M. Hönigsberger, A.V. Grasse, F. Wiesenhofer, N.
Kampleitner, M. Narasimhan, T. Schmitt, S. Cremer, Nature Ecology and Evolution
7 (2023) 450–460.
corr_author: '1'
date_created: 2023-02-12T23:00:59Z
date_published: 2023-03-01T00:00:00Z
date_updated: 2025-04-14T07:47:53Z
day: '01'
ddc:
- '570'
department:
- _id: SyCr
- _id: LifeSc
- _id: JiFr
doi: 10.1038/s41559-023-01981-6
ec_funded: 1
external_id:
isi:
- '000924572800001'
pmid:
- '36732670'
file:
- access_level: open_access
checksum: 8244f4650a0e7aeea488d1bcd4a31702
content_type: application/pdf
creator: dernst
date_created: 2023-08-16T11:54:59Z
date_updated: 2023-08-16T11:54:59Z
file_id: '14069'
file_name: 2023_NatureEcoEvo_Stock.pdf
file_size: 1600499
relation: main_file
success: 1
file_date_updated: 2023-08-16T11:54:59Z
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 450-460
pmid: 1
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
- _id: 25DAF0B2-B435-11E9-9278-68D0E5697425
grant_number: CR-118/3-1
name: Host-Parasite Coevolution
publication: Nature Ecology and Evolution
publication_identifier:
eissn:
- 2397-334X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/how-sneaky-germs-hide-from-ants/
scopus_import: '1'
status: public
title: Pathogen evasion of social immunity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2023'
...
---
_id: '12693'
abstract:
- lang: eng
text: See Readme File for further information.
article_processing_charge: No
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: 'Cremer S. Source data for Metzler et al, 2023: Trade-offs between immunity
and competitive ability in fighting ant males . 2023. doi:10.15479/AT:ISTA:12693'
apa: 'Cremer, S. (2023). Source data for Metzler et al, 2023: Trade-offs between
immunity and competitive ability in fighting ant males . Institute of Science
and Technology Austria. https://doi.org/10.15479/AT:ISTA:12693'
chicago: 'Cremer, Sylvia. “Source Data for Metzler et Al, 2023: Trade-Offs between
Immunity and Competitive Ability in Fighting Ant Males .” Institute of Science
and Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:12693.'
ieee: 'S. Cremer, “Source data for Metzler et al, 2023: Trade-offs between immunity
and competitive ability in fighting ant males .” Institute of Science and Technology
Austria, 2023.'
ista: 'Cremer S. 2023. Source data for Metzler et al, 2023: Trade-offs between immunity
and competitive ability in fighting ant males , Institute of Science and Technology
Austria, 10.15479/AT:ISTA:12693.'
mla: 'Cremer, Sylvia. Source Data for Metzler et Al, 2023: Trade-Offs between
Immunity and Competitive Ability in Fighting Ant Males . Institute of Science
and Technology Austria, 2023, doi:10.15479/AT:ISTA:12693.'
short: S. Cremer, (2023).
contributor:
- contributor_type: data_collector
first_name: Sina
id: 48204546-F248-11E8-B48F-1D18A9856A87
last_name: Metzler
- contributor_type: data_collector
first_name: Jessica
id: 21516227-15aa-11ec-9fb2-c6e8ffc155d3
last_name: Kirchner
- contributor_type: data_collector
first_name: Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
corr_author: '1'
date_created: 2023-02-28T06:38:37Z
date_published: 2023-02-28T00:00:00Z
date_updated: 2025-04-14T13:55:29Z
day: '28'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.15479/AT:ISTA:12693
file:
- access_level: open_access
checksum: c1565d655ca05601acfd84e0d12b8563
content_type: application/pdf
creator: scremer
date_created: 2023-02-28T06:34:08Z
date_updated: 2023-02-28T06:34:08Z
file_id: '12694'
file_name: Metzler_ReadMe.pdf
file_size: 77070
relation: main_file
success: 1
- access_level: open_access
checksum: 75c4c4948563d6261cb7548f80d909f1
content_type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
creator: scremer
date_created: 2023-02-28T06:34:12Z
date_updated: 2023-02-28T06:34:12Z
file_id: '12695'
file_name: Metzler_RepositoryData.xlsx
file_size: 88001
relation: main_file
success: 1
file_date_updated: 2023-02-28T06:34:12Z
has_accepted_license: '1'
month: '02'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '12696'
relation: used_in_publication
status: public
status: public
title: 'Source data for Metzler et al, 2023: Trade-offs between immunity and competitive
ability in fighting ant males '
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12696'
abstract:
- lang: eng
text: "Background: Fighting disease while fighting rivals exposes males to constraints
and tradeoffs during male-male competition. We here tested how both the stage
and intensity of infection with the fungal pathogen Metarhizium robertsii interfered
with fighting success in Cardiocondyla obscurior ant males. Males of this species
have evolved long lifespans during which they can gain many matings with the young
queens of the colony, if successful in male-male competition. Since male fights
occur inside the colony, the outcome of male-male competition can further be biased
by interference of the colony’s worker force.\r\nResults: We found that severe,
but not yet mild, infection strongly impaired male fighting success. In late-stage
infection, this could be attributed to worker aggression directed towards the
infected rather than the healthy male and an already very high male morbidity
even in the absence of fighting. Shortly after pathogen exposure, however, male
mortality was particularly increased during combat. Since these males mounted
a strong immune response, their reduced fighting success suggests a trade-off
between immune investment and competitive ability already early in the infection.
Even if the males themselves showed no difference in the number of attacks they
raised against their healthy rivals across infection stages and levels, severely
infected males were thus losing in male-male competition from an early stage of
infection on.\r\nConclusions: Males of the ant C. obscurior have evolved high
immune investment, triggering an effective immune response very fast after fungal
exposure. This allows them to cope with mild pathogen exposures without cost to
their success in male-male competition, and hence to gain multiple mating opportunities
with the emerging virgin queens of the colony. Under severe infection, however,
they are weak fighters and rarely survive a combat already at early infection
when raising an immune response, as well as at progressed infection, when they
are morbid and preferentially targeted by worker aggression. Workers thereby remove
males that pose a future disease threat by biasing male-male competition. Our
study thus revealed a novel social immunity mechanism how social insect workers
protect the colony against disease risk."
acknowledged_ssus:
- _id: LifeSc
acknowledgement: "We are thankful to Mike Bidochka for the fungal strain, Lukas Schrader
for sharing the C. obscurior genome data for primer development, the Lab Support
Facility of ISTA for general laboratory support and help with the permit approval
procedures, and the Finca El Quinto for letting us collect ants on their property.
We thank the Social Immunity Team at ISTA for help with ant collection and experimental
help, in particular Elina Hanhimäki and Marta Gorecka for behavioural observation,
and Elisabeth Naderlinger for spore load PCRs. We further thank the Social Immunity
Team and Jürgen Heinze for continued discussion and comments on the manuscript.\r\nOpen
access funding provided by Institute of Science and Technology Austria (ISTA). This
project received funding from the European Research Council (ERC) under the European
Union’s Horizon 2020 research and innovation programme (grant agreement No 771402
to SC). "
article_number: '37'
article_processing_charge: Yes
article_type: original
author:
- first_name: Sina
full_name: Metzler, Sina
id: 48204546-F248-11E8-B48F-1D18A9856A87
last_name: Metzler
orcid: 0000-0002-9547-2494
- first_name: Jessica
full_name: Kirchner, Jessica
id: 21516227-15aa-11ec-9fb2-c6e8ffc155d3
last_name: Kirchner
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Metzler S, Kirchner J, Grasse AV, Cremer S. Trade-offs between immunity and
competitive ability in fighting ant males. BMC Ecology and Evolution. 2023;23.
doi:10.1186/s12862-023-02137-7
apa: Metzler, S., Kirchner, J., Grasse, A. V., & Cremer, S. (2023). Trade-offs
between immunity and competitive ability in fighting ant males. BMC Ecology
and Evolution. Springer Nature. https://doi.org/10.1186/s12862-023-02137-7
chicago: Metzler, Sina, Jessica Kirchner, Anna V Grasse, and Sylvia Cremer. “Trade-Offs
between Immunity and Competitive Ability in Fighting Ant Males.” BMC Ecology
and Evolution. Springer Nature, 2023. https://doi.org/10.1186/s12862-023-02137-7.
ieee: S. Metzler, J. Kirchner, A. V. Grasse, and S. Cremer, “Trade-offs between
immunity and competitive ability in fighting ant males,” BMC Ecology and Evolution,
vol. 23. Springer Nature, 2023.
ista: Metzler S, Kirchner J, Grasse AV, Cremer S. 2023. Trade-offs between immunity
and competitive ability in fighting ant males. BMC Ecology and Evolution. 23,
37.
mla: Metzler, Sina, et al. “Trade-Offs between Immunity and Competitive Ability
in Fighting Ant Males.” BMC Ecology and Evolution, vol. 23, 37, Springer
Nature, 2023, doi:10.1186/s12862-023-02137-7.
short: S. Metzler, J. Kirchner, A.V. Grasse, S. Cremer, BMC Ecology and Evolution
23 (2023).
corr_author: '1'
date_created: 2023-02-28T07:38:17Z
date_published: 2023-08-07T00:00:00Z
date_updated: 2025-04-14T07:47:53Z
day: '07'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1186/s12862-023-02137-7
ec_funded: 1
external_id:
isi:
- '001042643600002'
pmid:
- '37550612'
file:
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checksum: 95966dc7d242d2c85bdd4fe14233dbd8
content_type: application/pdf
creator: dernst
date_created: 2023-08-14T07:51:47Z
date_updated: 2023-08-14T07:51:47Z
file_id: '14048'
file_name: 2023_BMCEcology_Metzler.pdf
file_size: 2004276
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file_date_updated: 2023-08-14T07:51:47Z
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intvolume: ' 23'
isi: 1
language:
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month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
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call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publication: BMC Ecology and Evolution
publication_identifier:
issn:
- 2730-7182
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
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relation: research_data
status: public
scopus_import: '1'
status: public
title: Trade-offs between immunity and competitive ability in fighting ant males
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2023'
...
---
OA_place: repository
OA_type: green
_id: '12765'
abstract:
- lang: eng
text: "Animals exhibit a variety of behavioural defences against socially transmitted
parasites. These defences evolved to increase host fitness by avoiding, resisting
or tolerating infection.\r\nBecause they can occur in both infected individuals
and their uninfected social partners, these defences often have important consequences
for the social group.\r\nHere, we discuss the evolution and ecology of anti-parasite
behavioural defences across a taxonomically wide social spectrum, considering
colonial groups, stable groups, transitional groups and solitary animals.\r\nWe
discuss avoidance, resistance and tolerance behaviours across these social group
structures, identifying how social complexity, group composition and interdependent
social relationships may contribute to the expression and evolution of behavioural
strategies.\r\nFinally, we outline avenues for further investigation such as approaches
to quantify group-level responses, and the connection of the physiological and
behavioural response to parasites in different social contexts."
article_processing_charge: No
article_type: review
author:
- first_name: Sebastian
full_name: Stockmaier, Sebastian
last_name: Stockmaier
- first_name: Yuko
full_name: Ulrich, Yuko
last_name: Ulrich
- first_name: Gregory F.
full_name: Albery, Gregory F.
last_name: Albery
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Patricia C.
full_name: Lopes, Patricia C.
last_name: Lopes
citation:
ama: Stockmaier S, Ulrich Y, Albery GF, Cremer S, Lopes PC. Behavioural defences
against parasites across host social structures. Functional Ecology. 2023;37(4):809-820.
doi:10.1111/1365-2435.14310
apa: Stockmaier, S., Ulrich, Y., Albery, G. F., Cremer, S., & Lopes, P. C. (2023).
Behavioural defences against parasites across host social structures. Functional
Ecology. British Ecological Society. https://doi.org/10.1111/1365-2435.14310
chicago: Stockmaier, Sebastian, Yuko Ulrich, Gregory F. Albery, Sylvia Cremer, and
Patricia C. Lopes. “Behavioural Defences against Parasites across Host Social
Structures.” Functional Ecology. British Ecological Society, 2023. https://doi.org/10.1111/1365-2435.14310.
ieee: S. Stockmaier, Y. Ulrich, G. F. Albery, S. Cremer, and P. C. Lopes, “Behavioural
defences against parasites across host social structures,” Functional Ecology,
vol. 37, no. 4. British Ecological Society, pp. 809–820, 2023.
ista: Stockmaier S, Ulrich Y, Albery GF, Cremer S, Lopes PC. 2023. Behavioural defences
against parasites across host social structures. Functional Ecology. 37(4), 809–820.
mla: Stockmaier, Sebastian, et al. “Behavioural Defences against Parasites across
Host Social Structures.” Functional Ecology, vol. 37, no. 4, British Ecological
Society, 2023, pp. 809–20, doi:10.1111/1365-2435.14310.
short: S. Stockmaier, Y. Ulrich, G.F. Albery, S. Cremer, P.C. Lopes, Functional
Ecology 37 (2023) 809–820.
date_created: 2023-03-26T22:01:09Z
date_published: 2023-04-01T00:00:00Z
date_updated: 2025-07-10T11:50:31Z
day: '01'
department:
- _id: SyCr
doi: 10.1111/1365-2435.14310
external_id:
isi:
- '000948940500001'
intvolume: ' 37'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://digitalcommons.chapman.edu/cgi/viewcontent.cgi?article=1585&context=sees_articles
month: '04'
oa: 1
oa_version: Submitted Version
page: 809-820
publication: Functional Ecology
publication_identifier:
eissn:
- 1365-2435
issn:
- 0269-8463
publication_status: published
publisher: British Ecological Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Behavioural defences against parasites across host social structures
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 37
year: '2023'
...
---
_id: '12945'
abstract:
- lang: eng
text: "basic data for use in code for experimental data analysis for manuscript
under revision: \r\nDynamic pathogen detection and social feedback shape collective
hygiene in ants\r\nCasillas-Pérez B, Boďová K, Grasse AV, Tkačik G, Cremer S"
acknowledged_ssus:
- _id: LifeSc
acknowledgement: This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(Grant No. 771402; EPIDEMICSonCHIP) to SC, from the Scientific Grant Agency of the
Slovak Republic (Grant No. 1/0521/20) to KB, and the Human Frontier Science Program
(Grant No. RGP0065/2012) to GT.
article_processing_charge: No
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: 'Cremer S. Data from: “Dynamic pathogen detection and social feedback shape
collective hygiene in ants” . 2023. doi:10.15479/AT:ISTA:12945'
apa: 'Cremer, S. (2023). Data from: “Dynamic pathogen detection and social feedback
shape collective hygiene in ants” . Institute of Science and Technology Austria.
https://doi.org/10.15479/AT:ISTA:12945'
chicago: 'Cremer, Sylvia. “Data from: ‘Dynamic Pathogen Detection and Social Feedback
Shape Collective Hygiene in Ants’ .” Institute of Science and Technology Austria,
2023. https://doi.org/10.15479/AT:ISTA:12945.'
ieee: 'S. Cremer, “Data from: ‘Dynamic pathogen detection and social feedback shape
collective hygiene in ants’ .” Institute of Science and Technology Austria, 2023.'
ista: 'Cremer S. 2023. Data from: ‘Dynamic pathogen detection and social feedback
shape collective hygiene in ants’ , Institute of Science and Technology Austria,
10.15479/AT:ISTA:12945.'
mla: 'Cremer, Sylvia. Data from: “Dynamic Pathogen Detection and Social Feedback
Shape Collective Hygiene in Ants” . Institute of Science and Technology Austria,
2023, doi:10.15479/AT:ISTA:12945.'
short: S. Cremer, (2023).
contributor:
- contributor_type: data_collector
first_name: Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
- contributor_type: data_collector
first_name: Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- contributor_type: researcher
first_name: Katarina
last_name: Bodova
- contributor_type: supervisor
first_name: Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
corr_author: '1'
date_created: 2023-05-11T21:35:17Z
date_published: 2023-05-12T00:00:00Z
date_updated: 2025-04-15T06:44:30Z
day: '12'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.15479/AT:ISTA:12945
file:
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checksum: 3eadf17fd59ad8c98bf10bf63061863c
content_type: application/zip
creator: scremer
date_created: 2023-05-12T08:04:04Z
date_updated: 2023-05-12T08:04:04Z
file_id: '12947'
file_name: Experimental_data.zip
file_size: 3414674
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date_created: 2023-05-12T08:04:08Z
date_updated: 2023-05-12T08:04:08Z
file_id: '12948'
file_name: README_Experimental_Data.md
file_size: 2113
relation: main_file
success: 1
file_date_updated: 2023-05-12T08:04:08Z
has_accepted_license: '1'
keyword:
- collective behavior
- host-pathogen interactions
- social immunity
- epidemiology
- social insects
- probabilistic modeling
month: '05'
oa: 1
oa_version: None
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '13127'
relation: used_in_publication
status: public
status: public
title: 'Data from: "Dynamic pathogen detection and social feedback shape collective
hygiene in ants" '
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '13127'
abstract:
- lang: eng
text: Cooperative disease defense emerges as group-level collective behavior, yet
how group members make the underlying individual decisions is poorly understood.
Using garden ants and fungal pathogens as an experimental model, we derive the
rules governing individual ant grooming choices and show how they produce colony-level
hygiene. Time-resolved behavioral analysis, pathogen quantification, and probabilistic
modeling reveal that ants increase grooming and preferentially target highly-infectious
individuals when perceiving high pathogen load, but transiently suppress grooming
after having been groomed by nestmates. Ants thus react to both, the infectivity
of others and the social feedback they receive on their own contagiousness. While
inferred solely from momentary ant decisions, these behavioral rules quantitatively
predict hour-long experimental dynamics, and synergistically combine into efficient
colony-wide pathogen removal. Our analyses show that noisy individual decisions
based on only local, incomplete, yet dynamically-updated information on pathogen
threat and social feedback can lead to potent collective disease defense.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: We thank Mike Bidochka for the fungal strains, the ISTA Social Immunity
Team for ant collection, Hanna Leitner for experimental and molecular support, Jennifer
Robb and Lukas Lindorfer for microscopy, and the LabSupport Facility at ISTA for
general laboratory support. We further thank Victor Mireles, Iain Couzin, Fabian
Theis and the Social Immunity Team for continued feedback throughout, and Michael
Sixt, Yuko Ulrich, Koos Boomsma, Erika Dawson, Megan Kutzer and Hinrich Schulenburg
for comments on the manuscript. This project has received funding from the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
program (Grant No. 771402; EPIDEMICSonCHIP) to SC, from the Scientific Grant Agency
of the Slovak Republic (Grant No. 1/0521/20) to KB, and the Human Frontier Science
Program (Grant No. RGP0065/2012) to GT.
article_number: '3232'
article_processing_charge: Yes
article_type: original
author:
- first_name: Barbara E
full_name: Casillas Perez, Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
- first_name: Katarína
full_name: Bod'Ová, Katarína
id: 2BA24EA0-F248-11E8-B48F-1D18A9856A87
last_name: Bod'Ová
orcid: 0000-0002-7214-0171
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Casillas Perez BE, Bodova K, Grasse AV, Tkačik G, Cremer S. Dynamic pathogen
detection and social feedback shape collective hygiene in ants. Nature Communications.
2023;14. doi:10.1038/s41467-023-38947-y
apa: Casillas Perez, B. E., Bodova, K., Grasse, A. V., Tkačik, G., & Cremer,
S. (2023). Dynamic pathogen detection and social feedback shape collective hygiene
in ants. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-023-38947-y
chicago: Casillas Perez, Barbara E, Katarina Bodova, Anna V Grasse, Gašper Tkačik,
and Sylvia Cremer. “Dynamic Pathogen Detection and Social Feedback Shape Collective
Hygiene in Ants.” Nature Communications. Springer Nature, 2023. https://doi.org/10.1038/s41467-023-38947-y.
ieee: B. E. Casillas Perez, K. Bodova, A. V. Grasse, G. Tkačik, and S. Cremer, “Dynamic
pathogen detection and social feedback shape collective hygiene in ants,” Nature
Communications, vol. 14. Springer Nature, 2023.
ista: Casillas Perez BE, Bodova K, Grasse AV, Tkačik G, Cremer S. 2023. Dynamic
pathogen detection and social feedback shape collective hygiene in ants. Nature
Communications. 14, 3232.
mla: Casillas Perez, Barbara E., et al. “Dynamic Pathogen Detection and Social Feedback
Shape Collective Hygiene in Ants.” Nature Communications, vol. 14, 3232,
Springer Nature, 2023, doi:10.1038/s41467-023-38947-y.
short: B.E. Casillas Perez, K. Bodova, A.V. Grasse, G. Tkačik, S. Cremer, Nature
Communications 14 (2023).
corr_author: '1'
date_created: 2023-06-11T22:00:40Z
date_published: 2023-06-03T00:00:00Z
date_updated: 2025-04-14T07:47:53Z
day: '03'
ddc:
- '570'
department:
- _id: SyCr
- _id: GaTk
doi: 10.1038/s41467-023-38947-y
ec_funded: 1
external_id:
isi:
- '001002562700005'
pmid:
- '37270641'
file:
- access_level: open_access
checksum: 4af0393e3ed47b3fc46e68b81c3c1007
content_type: application/pdf
creator: dernst
date_created: 2023-06-13T08:05:46Z
date_updated: 2023-06-13T08:05:46Z
file_id: '13132'
file_name: 2023_NatureComm_CasillasPerez.pdf
file_size: 2358167
relation: main_file
success: 1
file_date_updated: 2023-06-13T08:05:46Z
has_accepted_license: '1'
intvolume: ' 14'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
- _id: 255008E4-B435-11E9-9278-68D0E5697425
grant_number: RGP0065/2012
name: Information processing and computation in fish groups
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '12945'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Dynamic pathogen detection and social feedback shape collective hygiene in
ants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2023'
...
---
_id: '12133'
abstract:
- lang: eng
text: Social distancing is an effective way to prevent the spread of disease in
societies, whereas infection elimination is a key element of organismal immunity.
Here, we discuss how the study of social insects such as ants — which form a superorganism
of unconditionally cooperative individuals and thus represent a level of organization
that is intermediate between a classical society of individuals and an organism
of cells — can help to determine common principles of disease defence across levels
of organization.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Cremer S, Sixt MK. Principles of disease defence in organisms, superorganisms
and societies. Nature Reviews Immunology. 2022;22(12):713-714. doi:10.1038/s41577-022-00797-y
apa: Cremer, S., & Sixt, M. K. (2022). Principles of disease defence in organisms,
superorganisms and societies. Nature Reviews Immunology. Springer Nature.
https://doi.org/10.1038/s41577-022-00797-y
chicago: Cremer, Sylvia, and Michael K Sixt. “Principles of Disease Defence in Organisms,
Superorganisms and Societies.” Nature Reviews Immunology. Springer Nature,
2022. https://doi.org/10.1038/s41577-022-00797-y.
ieee: S. Cremer and M. K. Sixt, “Principles of disease defence in organisms, superorganisms
and societies,” Nature Reviews Immunology, vol. 22, no. 12. Springer Nature,
pp. 713–714, 2022.
ista: Cremer S, Sixt MK. 2022. Principles of disease defence in organisms, superorganisms
and societies. Nature Reviews Immunology. 22(12), 713–714.
mla: Cremer, Sylvia, and Michael K. Sixt. “Principles of Disease Defence in Organisms,
Superorganisms and Societies.” Nature Reviews Immunology, vol. 22, no.
12, Springer Nature, 2022, pp. 713–14, doi:10.1038/s41577-022-00797-y.
short: S. Cremer, M.K. Sixt, Nature Reviews Immunology 22 (2022) 713–714.
corr_author: '1'
date_created: 2023-01-12T12:03:14Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2024-10-09T21:03:33Z
day: '01'
department:
- _id: SyCr
- _id: MiSi
doi: 10.1038/s41577-022-00797-y
external_id:
isi:
- '000871836300001'
pmid:
- '36284178'
intvolume: ' 22'
isi: 1
issue: '12'
keyword:
- Energy Engineering and Power Technology
- Fuel Technology
language:
- iso: eng
month: '12'
oa_version: None
page: 713-714
pmid: 1
publication: Nature Reviews Immunology
publication_identifier:
eissn:
- 1474-1741
issn:
- 1474-1733
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Principles of disease defence in organisms, superorganisms and societies
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 22
year: '2022'
...
---
_id: '10284'
abstract:
- lang: eng
text: Infections early in life can have enduring effects on an organism's development
and immunity. In this study, we show that this equally applies to developing ‘superorganisms’––incipient
social insect colonies. When we exposed newly mated Lasius niger ant queens to
a low pathogen dose, their colonies grew more slowly than controls before winter,
but reached similar sizes afterwards. Independent of exposure, queen hibernation
survival improved when the ratio of pupae to workers was small. Queens that reared
fewer pupae before worker emergence exhibited lower pathogen levels, indicating
that high brood rearing efforts interfere with the ability of the queen's immune
system to suppress pathogen proliferation. Early-life queen pathogen exposure
also improved the immunocompetence of her worker offspring, as demonstrated by
challenging the workers to the same pathogen a year later. Transgenerational transfer
of the queen's pathogen experience to her workforce can hence durably reduce the
disease susceptibility of the whole superorganism.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: The authors are grateful to G. Tkačik and V. Mireles for advice on
data analyses and to A. Schloegl for help using the IST Austria HPC cluster for
data processing. The authors thank J. Eilenberg for providing the fungal strain
and A.V. Grasse for support with the molecular analysis. The authors also thank
the Social Immunity group at IST Austria, in particular B. Milutinović, for discussions
throughout and comments on the manuscript.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Barbara E
full_name: Casillas Perez, Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
- first_name: Christopher
full_name: Pull, Christopher
id: 3C7F4840-F248-11E8-B48F-1D18A9856A87
last_name: Pull
orcid: 0000-0003-1122-3982
- first_name: Filip
full_name: Naiser, Filip
last_name: Naiser
- first_name: Elisabeth
full_name: Naderlinger, Elisabeth
id: 31757262-F248-11E8-B48F-1D18A9856A87
last_name: Naderlinger
- first_name: Jiri
full_name: Matas, Jiri
last_name: Matas
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. Early
queen infection shapes developmental dynamics and induces long-term disease protection
in incipient ant colonies. Ecology Letters. 2022;25(1):89-100. doi:10.1111/ele.13907
apa: Casillas Perez, B. E., Pull, C., Naiser, F., Naderlinger, E., Matas, J., &
Cremer, S. (2022). Early queen infection shapes developmental dynamics and induces
long-term disease protection in incipient ant colonies. Ecology Letters.
Wiley. https://doi.org/10.1111/ele.13907
chicago: Casillas Perez, Barbara E, Christopher Pull, Filip Naiser, Elisabeth Naderlinger,
Jiri Matas, and Sylvia Cremer. “Early Queen Infection Shapes Developmental Dynamics
and Induces Long-Term Disease Protection in Incipient Ant Colonies.” Ecology
Letters. Wiley, 2022. https://doi.org/10.1111/ele.13907.
ieee: B. E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, and S.
Cremer, “Early queen infection shapes developmental dynamics and induces long-term
disease protection in incipient ant colonies,” Ecology Letters, vol. 25,
no. 1. Wiley, pp. 89–100, 2022.
ista: Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. 2022.
Early queen infection shapes developmental dynamics and induces long-term disease
protection in incipient ant colonies. Ecology Letters. 25(1), 89–100.
mla: Casillas Perez, Barbara E., et al. “Early Queen Infection Shapes Developmental
Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies.”
Ecology Letters, vol. 25, no. 1, Wiley, 2022, pp. 89–100, doi:10.1111/ele.13907.
short: B.E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, S. Cremer,
Ecology Letters 25 (2022) 89–100.
corr_author: '1'
date_created: 2021-11-14T23:01:25Z
date_published: 2022-01-01T00:00:00Z
date_updated: 2025-04-14T13:55:31Z
day: '01'
ddc:
- '573'
department:
- _id: SyCr
doi: 10.1111/ele.13907
ec_funded: 1
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title: Early queen infection shapes developmental dynamics and induces long-term disease
protection in incipient ant colonies
tmp:
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legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
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abstract:
- lang: eng
text: Infections early in life can have enduring effects on an organism’s development
and immunity. In this study, we show that this equally applies to developing “superorganisms”
– incipient social insect colonies. When we exposed newly mated Lasius niger ant
queens to a low pathogen dose, their colonies grew more slowly than controls before
winter, but reached similar sizes afterwards. Independent of exposure, queen hibernation
survival improved when the ratio of pupae to workers was small. Queens that reared
fewer pupae before worker emergence exhibited lower pathogen levels, indicating
that high brood rearing efforts interfere with the ability of the queen’s immune
system to suppress pathogen proliferation. Early-life queen pathogen-exposure
also improved the immunocompetence of her worker offspring, as demonstrated by
challenging the workers to the same pathogen a year later. Transgenerational transfer
of the queen’s pathogen experience to her workforce can hence durably reduce the
disease susceptibility of the whole superorganism.
article_processing_charge: No
author:
- first_name: Barbara E
full_name: Casillas Perez, Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
- first_name: Christopher
full_name: Pull, Christopher
id: 3C7F4840-F248-11E8-B48F-1D18A9856A87
last_name: Pull
orcid: 0000-0003-1122-3982
- first_name: Filip
full_name: Naiser, Filip
last_name: Naiser
- first_name: Elisabeth
full_name: Naderlinger, Elisabeth
last_name: Naderlinger
- first_name: Jiri
full_name: Matas, Jiri
last_name: Matas
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. Early
queen infection shapes developmental dynamics and induces long-term disease protection
in incipient ant colonies. 2021. doi:10.5061/DRYAD.7PVMCVDTJ
apa: Casillas Perez, B. E., Pull, C., Naiser, F., Naderlinger, E., Matas, J., &
Cremer, S. (2021). Early queen infection shapes developmental dynamics and induces
long-term disease protection in incipient ant colonies. Dryad. https://doi.org/10.5061/DRYAD.7PVMCVDTJ
chicago: Casillas Perez, Barbara E, Christopher Pull, Filip Naiser, Elisabeth Naderlinger,
Jiri Matas, and Sylvia Cremer. “Early Queen Infection Shapes Developmental Dynamics
and Induces Long-Term Disease Protection in Incipient Ant Colonies.” Dryad, 2021.
https://doi.org/10.5061/DRYAD.7PVMCVDTJ.
ieee: B. E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, and S.
Cremer, “Early queen infection shapes developmental dynamics and induces long-term
disease protection in incipient ant colonies.” Dryad, 2021.
ista: Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. 2021.
Early queen infection shapes developmental dynamics and induces long-term disease
protection in incipient ant colonies, Dryad, 10.5061/DRYAD.7PVMCVDTJ.
mla: Casillas Perez, Barbara E., et al. Early Queen Infection Shapes Developmental
Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies.
Dryad, 2021, doi:10.5061/DRYAD.7PVMCVDTJ.
short: B.E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, S. Cremer,
(2021).
corr_author: '1'
date_created: 2023-05-23T16:14:35Z
date_published: 2021-10-29T00:00:00Z
date_updated: 2025-04-14T13:55:31Z
day: '29'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.5061/DRYAD.7PVMCVDTJ
ec_funded: 1
license: https://creativecommons.org/publicdomain/zero/1.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.7pvmcvdtj
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publisher: Dryad
related_material:
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relation: used_in_publication
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title: Early queen infection shapes developmental dynamics and induces long-term disease
protection in incipient ant colonies
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
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---
_id: '13060'
abstract:
- lang: eng
text: Coinfections with multiple pathogens can result in complex within-host dynamics
affecting virulence and transmission. Whilst multiple infections are intensively
studied in solitary hosts, it is so far unresolved how social host interactions
interfere with pathogen competition, and if this depends on coinfection diversity.
We studied how the collective disease defenses of ants – their social immunity
– influence pathogen competition in coinfections of same or different fungal
pathogen species. Social immunity reduced virulence for all pathogen combinations,
but interfered with spore production only in different-species coinfections. Here,
it decreased overall pathogen sporulation success, whilst simultaneously increasing
co-sporulation on individual cadavers and maintaining a higher pathogen diversity
at the community-level. Mathematical modeling revealed that host sanitary care
alone can modulate competitive outcomes between pathogens, giving advantage to
fast-germinating, thus less grooming-sensitive ones. Host social interactions
can hence modulate infection dynamics in coinfected group members, thereby altering
pathogen communities at the host- and population-level.
article_processing_charge: No
author:
- first_name: Barbara
full_name: Milutinovic, Barbara
id: 2CDC32B8-F248-11E8-B48F-1D18A9856A87
last_name: Milutinovic
orcid: 0000-0002-8214-4758
- first_name: Miriam
full_name: Stock, Miriam
id: 42462816-F248-11E8-B48F-1D18A9856A87
last_name: Stock
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Elisabeth
full_name: Naderlinger, Elisabeth
id: 31757262-F248-11E8-B48F-1D18A9856A87
last_name: Naderlinger
- first_name: Christian
full_name: Hilbe, Christian
id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
last_name: Hilbe
orcid: 0000-0001-5116-955X
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. Social
immunity modulates competition between coinfecting pathogens. 2020. doi:10.5061/DRYAD.CRJDFN318
apa: Milutinovic, B., Stock, M., Grasse, A. V., Naderlinger, E., Hilbe, C., &
Cremer, S. (2020). Social immunity modulates competition between coinfecting pathogens.
Dryad. https://doi.org/10.5061/DRYAD.CRJDFN318
chicago: Milutinovic, Barbara, Miriam Stock, Anna V Grasse, Elisabeth Naderlinger,
Christian Hilbe, and Sylvia Cremer. “Social Immunity Modulates Competition between
Coinfecting Pathogens.” Dryad, 2020. https://doi.org/10.5061/DRYAD.CRJDFN318.
ieee: B. Milutinovic, M. Stock, A. V. Grasse, E. Naderlinger, C. Hilbe, and S. Cremer,
“Social immunity modulates competition between coinfecting pathogens.” Dryad,
2020.
ista: Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. 2020.
Social immunity modulates competition between coinfecting pathogens, Dryad, 10.5061/DRYAD.CRJDFN318.
mla: Milutinovic, Barbara, et al. Social Immunity Modulates Competition between
Coinfecting Pathogens. Dryad, 2020, doi:10.5061/DRYAD.CRJDFN318.
short: B. Milutinovic, M. Stock, A.V. Grasse, E. Naderlinger, C. Hilbe, S. Cremer,
(2020).
corr_author: '1'
date_created: 2023-05-23T16:11:22Z
date_published: 2020-12-19T00:00:00Z
date_updated: 2025-06-12T07:32:35Z
day: '19'
ddc:
- '570'
department:
- _id: SyCr
- _id: KrCh
doi: 10.5061/DRYAD.CRJDFN318
main_file_link:
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url: https://doi.org/10.5061/dryad.crjdfn318
month: '12'
oa: 1
oa_version: Published Version
publisher: Dryad
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status: public
title: Social immunity modulates competition between coinfecting pathogens
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short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...