@article{19544,
  abstract     = {Medicinal bioinorganic chemistry is a thriving field of drug research for cancer treatment. Transition metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target-specific therapeutics. We report here the biological evaluation of a novel Isatin-Schiff base derivative and its Cu(II) complex in several tumor cell lines by assessing their effects on cellular metabolism, real-time cell proliferation and induction of apoptosis. Further, the impact of compounds on the p53 protein and expression of its target genes, including MDM2, p21/CDKN1A, and PUMA was evaluated. Results obtained in this study provide further evidence in support of our prior data suggesting the p53-mediated mechanism of action for Isatin-Schiff base derivatives and their complexes and also shed light on potential use of these compounds for stimulation of apoptosis in breast cancer cells via activation of the pro-apoptotic PUMA gene.},
  author       = {Bulatov, Emil and Sayarova, Regina and Mingaleeva, Rimma and Miftakhova, Regina and Gomzikova, Marina and Ignatev, Iurii and Petukhov, Alexey and Davidovich, Pavel and Rizvanov, Albert and Barlev, Nickolai A.},
  issn         = {2058-7716},
  journal      = {Cell Death Discovery},
  publisher    = {Springer Nature},
  title        = {{Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors}},
  doi          = {10.1038/s41420-018-0120-z},
  volume       = {4},
  year         = {2018},
}