---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19544'
abstract:
- lang: eng
  text: Medicinal bioinorganic chemistry is a thriving field of drug research for
    cancer treatment. Transition metal complexes coordinated to essential biological
    scaffolds represent a highly promising class of compounds for design of novel
    target-specific therapeutics. We report here the biological evaluation of a novel
    Isatin-Schiff base derivative and its Cu(II) complex in several tumor cell lines
    by assessing their effects on cellular metabolism, real-time cell proliferation
    and induction of apoptosis. Further, the impact of compounds on the p53 protein
    and expression of its target genes, including MDM2, p21/CDKN1A, and PUMA was evaluated.
    Results obtained in this study provide further evidence in support of our prior
    data suggesting the p53-mediated mechanism of action for Isatin-Schiff base derivatives
    and their complexes and also shed light on potential use of these compounds for
    stimulation of apoptosis in breast cancer cells via activation of the pro-apoptotic
    PUMA gene.
article_number: '103'
article_processing_charge: Yes
article_type: original
author:
- first_name: Emil
  full_name: Bulatov, Emil
  last_name: Bulatov
- first_name: Regina
  full_name: Sayarova, Regina
  last_name: Sayarova
- first_name: Rimma
  full_name: Mingaleeva, Rimma
  last_name: Mingaleeva
- first_name: Regina
  full_name: Miftakhova, Regina
  last_name: Miftakhova
- first_name: Marina
  full_name: Gomzikova, Marina
  last_name: Gomzikova
- first_name: Iurii
  full_name: Ignatev, Iurii
  id: 2ac71786-dc7d-11ea-9b2f-c5ad4b9faff6
  last_name: Ignatev
- first_name: Alexey
  full_name: Petukhov, Alexey
  last_name: Petukhov
- first_name: Pavel
  full_name: Davidovich, Pavel
  last_name: Davidovich
- first_name: Albert
  full_name: Rizvanov, Albert
  last_name: Rizvanov
- first_name: Nickolai A.
  full_name: Barlev, Nickolai A.
  last_name: Barlev
citation:
  ama: Bulatov E, Sayarova R, Mingaleeva R, et al. Isatin-Schiff base-copper (II)
    complex induces cell death in p53-positive tumors. <i>Cell Death Discovery</i>.
    2018;4. doi:<a href="https://doi.org/10.1038/s41420-018-0120-z">10.1038/s41420-018-0120-z</a>
  apa: Bulatov, E., Sayarova, R., Mingaleeva, R., Miftakhova, R., Gomzikova, M., Ignatev,
    I., … Barlev, N. A. (2018). Isatin-Schiff base-copper (II) complex induces cell
    death in p53-positive tumors. <i>Cell Death Discovery</i>. Springer Nature. <a
    href="https://doi.org/10.1038/s41420-018-0120-z">https://doi.org/10.1038/s41420-018-0120-z</a>
  chicago: Bulatov, Emil, Regina Sayarova, Rimma Mingaleeva, Regina Miftakhova, Marina
    Gomzikova, Iurii Ignatev, Alexey Petukhov, Pavel Davidovich, Albert Rizvanov,
    and Nickolai A. Barlev. “Isatin-Schiff Base-Copper (II) Complex Induces Cell Death
    in P53-Positive Tumors.” <i>Cell Death Discovery</i>. Springer Nature, 2018. <a
    href="https://doi.org/10.1038/s41420-018-0120-z">https://doi.org/10.1038/s41420-018-0120-z</a>.
  ieee: E. Bulatov <i>et al.</i>, “Isatin-Schiff base-copper (II) complex induces
    cell death in p53-positive tumors,” <i>Cell Death Discovery</i>, vol. 4. Springer
    Nature, 2018.
  ista: Bulatov E, Sayarova R, Mingaleeva R, Miftakhova R, Gomzikova M, Ignatev I,
    Petukhov A, Davidovich P, Rizvanov A, Barlev NA. 2018. Isatin-Schiff base-copper
    (II) complex induces cell death in p53-positive tumors. Cell Death Discovery.
    4, 103.
  mla: Bulatov, Emil, et al. “Isatin-Schiff Base-Copper (II) Complex Induces Cell
    Death in P53-Positive Tumors.” <i>Cell Death Discovery</i>, vol. 4, 103, Springer
    Nature, 2018, doi:<a href="https://doi.org/10.1038/s41420-018-0120-z">10.1038/s41420-018-0120-z</a>.
  short: E. Bulatov, R. Sayarova, R. Mingaleeva, R. Miftakhova, M. Gomzikova, I. Ignatev,
    A. Petukhov, P. Davidovich, A. Rizvanov, N.A. Barlev, Cell Death Discovery 4 (2018).
date_created: 2025-04-11T01:31:42Z
date_published: 2018-11-13T00:00:00Z
date_updated: 2025-07-10T11:51:52Z
day: '13'
ddc:
- '570'
department:
- _id: GradSch
- _id: LoSw
doi: 10.1038/s41420-018-0120-z
extern: '1'
external_id:
  pmid:
  - '30455989 '
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41420-018-0120-z
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cell Death Discovery
publication_identifier:
  issn:
  - 2058-7716
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2018'
...