TY - JOUR AB - Novelty facilitates formation of memories. The detection of novelty and storage of contextual memories are both mediated by the hippocampus, yet the mechanisms that link these two functions remain to be defined. Dentate granule cells (GCs) of the dorsal hippocampus fire upon novelty exposure forming engrams of contextual memory. However, their key excitatory inputs from the entorhinal cortex are not responsive to novelty and are insufficient to make dorsal GCs fire reliably. Here we uncover a powerful glutamatergic pathway to dorsal GCs from ventral hippocampal mossy cells (MCs) that relays novelty, and is necessary and sufficient for driving dorsal GCs activation. Furthermore, manipulation of ventral MCs activity bidirectionally regulates novelty-induced contextual memory acquisition. Our results show that ventral MCs activity controls memory formation through an intra-hippocampal interaction mechanism gated by novelty. AU - Fredes Tolorza, Felipe A AU - Silva Sifuentes, Maria A AU - Koppensteiner, Peter AU - Kobayashi, Kenta AU - Jösch, Maximilian A AU - Shigemoto, Ryuichi ID - 7551 IS - 1 JF - Current Biology TI - Ventro-dorsal hippocampal pathway gates novelty-induced contextual memory formation VL - 31 ER -