---
OA_place: publisher
OA_type: hybrid
_id: '15381'
abstract:
- lang: eng
text: 'Cholecystokinin-expressing interneurons (CCKIs) are hypothesized to shape
pyramidal cell-firing patterns and regulate network oscillations and related network
state transitions. To directly probe their role in the CA1 region, we silenced
their activity using optogenetic and chemogenetic tools in mice. Opto-tagged CCKIs
revealed a heterogeneous population, and their optogenetic silencing triggered
wide disinhibitory network changes affecting both pyramidal cells and other interneurons.
CCKI silencing enhanced pyramidal cell burst firing and altered the temporal coding
of place cells: theta phase precession was disrupted, whereas sequence reactivation
was enhanced. Chemogenetic CCKI silencing did not alter the acquisition of spatial
reference memories on the Morris water maze but enhanced the recall of contextual
fear memories and enabled selective recall when similar environments were tested.
This work suggests the key involvement of CCKIs in the control of place-cell temporal
coding and the formation of contextual memories.'
acknowledged_ssus:
- _id: M-Shop
- _id: Bio
- _id: LifeSc
- _id: PreCl
acknowledgement: We thank the kind donations from Andrea Varro, Brian Sauer, Edward
Boyden, and Peter Jonas. We thank Jago Wallenschus, Kerstin Kronenbitter, and Didier
Gremelle for outstanding technical support; Laura Bollepalli for initial viral targeting
experiments; Cihan Önal for initial electrophysiology experiments; Yoav Ben-Simon
for histological advice; and Anton Nikitenko for contributing to the analysis. We
acknowledge support from the Miba Machine Shop, Bioimaging-, Life Science- and Pre-Clinical
Facilities at ISTA. This work was supported by the Austrian Science Fund (FWF I3713
to J.C. as part of the FOR 2143 research consortium), the Deutsche Forschungsgemeinschaft
(DFG) (WU 503/2-2 to P.W.), and the Medical Research Council, United Kingdom (grant
G1100546/2 to P.W.).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Dámaris K
full_name: Rangel Guerrero, Dámaris K
id: 4871BCE6-F248-11E8-B48F-1D18A9856A87
last_name: Rangel Guerrero
orcid: 0000-0002-8602-4374
- first_name: Kira
full_name: Balueva, Kira
last_name: Balueva
- first_name: Uladzislau
full_name: Barayeu, Uladzislau
id: b515be12-ec90-11ea-b966-d0b5e15613d2
last_name: Barayeu
- first_name: Peter
full_name: Baracskay, Peter
id: 361CC00E-F248-11E8-B48F-1D18A9856A87
last_name: Baracskay
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Chiara N
full_name: Roth, Chiara N
id: 37BB4FB6-F248-11E8-B48F-1D18A9856A87
last_name: Roth
- first_name: Peer
full_name: Wulff, Peer
last_name: Wulff
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Rangel Guerrero DK, Balueva K, Barayeu U, et al. Hippocampal cholecystokinin-expressing
interneurons regulate temporal coding and contextual learning. Neuron.
2024;112(12):2045-2061.e10. doi:10.1016/j.neuron.2024.03.019
apa: Rangel Guerrero, D. K., Balueva, K., Barayeu, U., Baracskay, P., Gridchyn,
I., Nardin, M., … Csicsvari, J. L. (2024). Hippocampal cholecystokinin-expressing
interneurons regulate temporal coding and contextual learning. Neuron.
Cell Press. https://doi.org/10.1016/j.neuron.2024.03.019
chicago: Rangel Guerrero, Dámaris K, Kira Balueva, Uladzislau Barayeu, Peter Baracskay,
Igor Gridchyn, Michele Nardin, Chiara N Roth, Peer Wulff, and Jozsef L Csicsvari.
“Hippocampal Cholecystokinin-Expressing Interneurons Regulate Temporal Coding
and Contextual Learning.” Neuron. Cell Press, 2024. https://doi.org/10.1016/j.neuron.2024.03.019.
ieee: D. K. Rangel Guerrero et al., “Hippocampal cholecystokinin-expressing
interneurons regulate temporal coding and contextual learning,” Neuron,
vol. 112, no. 12. Cell Press, p. 2045–2061.e10, 2024.
ista: Rangel Guerrero DK, Balueva K, Barayeu U, Baracskay P, Gridchyn I, Nardin
M, Roth CN, Wulff P, Csicsvari JL. 2024. Hippocampal cholecystokinin-expressing
interneurons regulate temporal coding and contextual learning. Neuron. 112(12),
2045–2061.e10.
mla: Rangel Guerrero, Dámaris K., et al. “Hippocampal Cholecystokinin-Expressing
Interneurons Regulate Temporal Coding and Contextual Learning.” Neuron,
vol. 112, no. 12, Cell Press, 2024, p. 2045–2061.e10, doi:10.1016/j.neuron.2024.03.019.
short: D.K. Rangel Guerrero, K. Balueva, U. Barayeu, P. Baracskay, I. Gridchyn,
M. Nardin, C.N. Roth, P. Wulff, J.L. Csicsvari, Neuron 112 (2024) 2045–2061.e10.
corr_author: '1'
date_created: 2024-05-12T22:01:03Z
date_published: 2024-06-19T00:00:00Z
date_updated: 2025-09-08T07:26:42Z
day: '19'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2024.03.019
external_id:
isi:
- '001300571400001'
pmid:
- '38636524'
file:
- access_level: open_access
checksum: de5b18ff293d42bd90e83a193e889844
content_type: application/pdf
creator: dernst
date_created: 2025-01-09T09:15:31Z
date_updated: 2025-01-09T09:15:31Z
file_id: '18798'
file_name: 2024_Neuron_RangelGuerrero.pdf
file_size: 9149079
relation: main_file
success: 1
file_date_updated: 2025-01-09T09:15:31Z
has_accepted_license: '1'
intvolume: ' 112'
isi: 1
issue: '12'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 2045-2061.e10
pmid: 1
project:
- _id: 2654F984-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I 3713-B27
name: Interneuro plasticity during spatial learning
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
issn:
- 0896-6273
publication_status: published
publisher: Cell Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hippocampal cholecystokinin-expressing interneurons regulate temporal coding
and contextual learning
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 112
year: '2024'
...