---
OA_place: publisher
OA_type: hybrid
_id: '18621'
abstract:
- lang: eng
text: During neural development, cellular adhesion is crucial for interactions among
and between neurons and surrounding tissues. This function is mediated by conserved
cell adhesion molecules, which are tightly regulated to allow for coordinated
neuronal outgrowth. Here, we show that the proprotein convertase KPC-1 (homolog
of mammalian furin) regulates the Menorin adhesion complex during development
of PVD dendritic arbors in Caenorhabditis elegans. We found a finely regulated
antagonistic balance between PVD-expressed KPC-1 and the epidermally expressed
putative cell adhesion molecule MNR-1 (Menorin). Genetically, partial loss of
mnr-1 suppressed partial loss of kpc-1, and both loss of kpc-1 and transgenic
overexpression of mnr-1 resulted in indistinguishable phenotypes in PVD dendrites.
This balance regulated cell-surface localization of the DMA-1 leucine-rich transmembrane
receptor in PVD neurons. Lastly, kpc-1 mutants showed increased amounts of MNR-1
and decreased amounts of muscle-derived LECT-2 (Chondromodulin II), which is also
part of the Menorin adhesion complex. These observations suggest that KPC-1 in
PVD neurons directly or indirectly controls the abundance of proteins of the Menorin
adhesion complex from adjacent tissues, thereby providing negative feedback from
the dendrite to the instructive cues of surrounding tissues.
acknowledgement: "We thank members of the Bülow laboratory for comments on the manuscript
and discussions throughout the course of this work; and Ryan Peer and William Corman
for their initial help with the modifier genetic screen. We acknowledge the Genomics
Core facility and the Advanced Imaging Facility at Albert Einstein College of Medicine
for help during these studies. We are grateful to Kang Shen, David Miller and the
Caenorhabditis Genetics Center (which is funded by National Institutes of Health
Office of Research Infrastructure Programs P40OD0104400) for some of the strains
used in this study, and Lhisia Chen for the anti-SAX-7 antibody.\r\nThis work was
supported by grants from the National Institutes of Health (F31NS100370 to M.R.;
T32GM007288 and F31NS111939 to M.T.; R01NS096672, R21NS081505 and R01NS129992 to
H.E.B.; and P30HD071593 to Albert Einstein College of Medicine). N.J.R.-S. was the
recipient of a Colciencias-Fulbright Fellowship [funded by Departamento Administrativo
de Ciencia, Tecnología e Innovación (COLCIENCIAS) and Fulbright Colombia], L.T.H.T.
of a Croucher Foundation Fellowship, and H.E.B. of an Irma T. Hirschl Trust/Monique
Weill-Caulier Trust research fellowship. Open Access funding provided by Albert
Einstein College of Medicine, Yeshiva University. Deposited in PMC for immediate
release."
article_processing_charge: No
article_type: original
author:
- first_name: Nelson
full_name: Ramirez, Nelson
id: 39831956-E4FE-11E9-85DE-0DC7E5697425
last_name: Ramirez
- first_name: Helen M.
full_name: Belalcazar, Helen M.
last_name: Belalcazar
- first_name: Maisha
full_name: Rahman, Maisha
last_name: Rahman
- first_name: Meera
full_name: Trivedi, Meera
last_name: Trivedi
- first_name: Leo T. H.
full_name: Tang, Leo T. H.
last_name: Tang
- first_name: Hannes E.
full_name: Bülow, Hannes E.
last_name: Bülow
citation:
ama: Ramirez N, Belalcazar HM, Rahman M, Trivedi M, Tang LTH, Bülow HE. Convertase-dependent
regulation of membrane-tethered and secreted ligands tunes dendrite adhesion.
Development. 2023;150(18). doi:10.1242/dev.201208
apa: Ramirez, N., Belalcazar, H. M., Rahman, M., Trivedi, M., Tang, L. T. H., &
Bülow, H. E. (2023). Convertase-dependent regulation of membrane-tethered and
secreted ligands tunes dendrite adhesion. Development. The Company of Biologists.
https://doi.org/10.1242/dev.201208
chicago: Ramirez, Nelson, Helen M. Belalcazar, Maisha Rahman, Meera Trivedi, Leo
T. H. Tang, and Hannes E. Bülow. “Convertase-Dependent Regulation of Membrane-Tethered
and Secreted Ligands Tunes Dendrite Adhesion.” Development. The Company
of Biologists, 2023. https://doi.org/10.1242/dev.201208.
ieee: N. Ramirez, H. M. Belalcazar, M. Rahman, M. Trivedi, L. T. H. Tang, and H.
E. Bülow, “Convertase-dependent regulation of membrane-tethered and secreted ligands
tunes dendrite adhesion,” Development, vol. 150, no. 18. The Company of
Biologists, 2023.
ista: Ramirez N, Belalcazar HM, Rahman M, Trivedi M, Tang LTH, Bülow HE. 2023. Convertase-dependent
regulation of membrane-tethered and secreted ligands tunes dendrite adhesion.
Development. 150(18).
mla: Ramirez, Nelson, et al. “Convertase-Dependent Regulation of Membrane-Tethered
and Secreted Ligands Tunes Dendrite Adhesion.” Development, vol. 150, no.
18, The Company of Biologists, 2023, doi:10.1242/dev.201208.
short: N. Ramirez, H.M. Belalcazar, M. Rahman, M. Trivedi, L.T.H. Tang, H.E. Bülow,
Development 150 (2023).
date_created: 2024-12-04T22:02:52Z
date_published: 2023-09-18T00:00:00Z
date_updated: 2024-12-09T11:43:40Z
day: '18'
ddc:
- '570'
doi: 10.1242/dev.201208
extern: '1'
external_id:
pmid:
- '37721334'
file:
- access_level: open_access
checksum: d2158dc56db50457e6404c4afec4401c
content_type: application/pdf
creator: nramirez
date_created: 2024-12-04T22:12:04Z
date_updated: 2024-12-04T22:12:04Z
file_id: '18624'
file_name: dev201208.pdf
file_size: 9559527
relation: main_file
success: 1
file_date_updated: 2024-12-04T22:12:04Z
fulldoi: https://doi.org/10.1242/dev.201208
has_accepted_license: '1'
intvolume: ' 150'
issue: '18'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
publication: Development
publication_identifier:
eissn:
- 1477-9129
issn:
- 0950-1991
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Convertase-dependent regulation of membrane-tethered and secreted ligands tunes
dendrite adhesion
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 150
year: '2023'
...
---
_id: '11637'
abstract:
- lang: eng
text: The ability to detect and respond to acute oxygen (O2) shortages is indispensable
to aerobic life. The molecular mechanisms and circuits underlying this capacity
are poorly understood. Here, we characterize the behavioral responses of feeding
Caenorhabditis elegans to approximately 1% O2. Acute hypoxia triggers a bout of
turning maneuvers followed by a persistent switch to rapid forward movement as
animals seek to avoid and escape hypoxia. While the behavioral responses to 1%
O2 closely resemble those evoked by 21% O2, they have distinct molecular and circuit
underpinnings. Disrupting phosphodiesterases (PDEs), specific G proteins, or BBSome
function inhibits escape from 1% O2 due to increased cGMP signaling. A primary
source of cGMP is GCY-28, the ortholog of the atrial natriuretic peptide (ANP)
receptor. cGMP activates the protein kinase G EGL-4 and enhances neuroendocrine
secretion to inhibit acute responses to 1% O2. Triggering a rise in cGMP optogenetically
in multiple neurons, including AIA interneurons, rapidly and reversibly inhibits
escape from 1% O2. Ca2+ imaging reveals that a 7% to 1% O2 stimulus evokes a Ca2+
decrease in several neurons. Defects in mitochondrial complex I (MCI) and mitochondrial
complex I (MCIII), which lead to persistently high reactive oxygen species (ROS),
abrogate acute hypoxia responses. In particular, repressing the expression of
isp-1, which encodes the iron sulfur protein of MCIII, inhibits escape from 1%
O2 without affecting responses to 21% O2. Both genetic and pharmacological up-regulation
of mitochondrial ROS increase cGMP levels, which contribute to the reduced hypoxia
responses. Our results implicate ROS and precise regulation of intracellular cGMP
in the modulation of acute responses to hypoxia by C. elegans.
acknowledgement: ' This work was funded by H2020 European Research Council (ERC Advanced
grant, 269058 ACMO, https://erc.europa.eu/funding/advanced-grants) and Wellcome
Trust UK (Wellcome Investigator Award, 209504/Z/17/Z, https://wellcome.org/grant-funding/people-and-projects/grants-awarded/molecular-mechanisms-neural-circuit-function-0)
to M.d.B, and by H2020 European Research Council (ERC starting grant, 802653 OXYGEN
SENSING, https://erc.europa.eu/funding/starting-grants) and Vetenskapsrådet (VR
starting grant, 2018-02216, https://www.vr.se/english.html) to C.C. The funders
had no role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.'
article_number: e3001684
article_processing_charge: No
article_type: original
author:
- first_name: Lina
full_name: Zhao, Lina
last_name: Zhao
- first_name: Lorenz A.
full_name: Fenk, Lorenz A.
last_name: Fenk
- first_name: Lars
full_name: Nilsson, Lars
last_name: Nilsson
- first_name: Niko Paresh
full_name: Amin-Wetzel, Niko Paresh
id: E95D3014-9D8C-11E9-9C80-D2F8E5697425
last_name: Amin-Wetzel
- first_name: Nelson
full_name: Ramirez, Nelson
id: 39831956-E4FE-11E9-85DE-0DC7E5697425
last_name: Ramirez
- first_name: Mario
full_name: De Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: De Bono
orcid: 0000-0001-8347-0443
- first_name: Changchun
full_name: Chen, Changchun
last_name: Chen
citation:
ama: Zhao L, Fenk LA, Nilsson L, et al. ROS and cGMP signaling modulate persistent
escape from hypoxia in Caenorhabditis elegans. PLoS Biology. 2022;20(6).
doi:10.1371/journal.pbio.3001684
apa: Zhao, L., Fenk, L. A., Nilsson, L., Amin-Wetzel, N. P., Ramirez, N., de Bono,
M., & Chen, C. (2022). ROS and cGMP signaling modulate persistent escape from
hypoxia in Caenorhabditis elegans. PLoS Biology. Public Library of Science.
https://doi.org/10.1371/journal.pbio.3001684
chicago: Zhao, Lina, Lorenz A. Fenk, Lars Nilsson, Niko Paresh Amin-Wetzel, Nelson
Ramirez, Mario de Bono, and Changchun Chen. “ROS and CGMP Signaling Modulate Persistent
Escape from Hypoxia in Caenorhabditis Elegans.” PLoS Biology. Public Library
of Science, 2022. https://doi.org/10.1371/journal.pbio.3001684.
ieee: L. Zhao et al., “ROS and cGMP signaling modulate persistent escape
from hypoxia in Caenorhabditis elegans,” PLoS Biology, vol. 20, no. 6.
Public Library of Science, 2022.
ista: Zhao L, Fenk LA, Nilsson L, Amin-Wetzel NP, Ramirez N, de Bono M, Chen C.
2022. ROS and cGMP signaling modulate persistent escape from hypoxia in Caenorhabditis
elegans. PLoS Biology. 20(6), e3001684.
mla: Zhao, Lina, et al. “ROS and CGMP Signaling Modulate Persistent Escape from
Hypoxia in Caenorhabditis Elegans.” PLoS Biology, vol. 20, no. 6, e3001684,
Public Library of Science, 2022, doi:10.1371/journal.pbio.3001684.
short: L. Zhao, L.A. Fenk, L. Nilsson, N.P. Amin-Wetzel, N. Ramirez, M. de Bono,
C. Chen, PLoS Biology 20 (2022).
corr_author: '1'
date_created: 2022-07-24T22:01:42Z
date_published: 2022-06-21T00:00:00Z
date_updated: 2025-04-15T07:32:21Z
day: '21'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1371/journal.pbio.3001684
external_id:
isi:
- '000828679600001'
pmid:
- '35727855'
file:
- access_level: open_access
checksum: df4902f854ad76769d3203bfdc69f16c
content_type: application/pdf
creator: dernst
date_created: 2022-07-25T07:38:49Z
date_updated: 2022-07-25T07:38:49Z
file_id: '11643'
file_name: 2022_PLoSBiology_Zhao.pdf
file_size: 3721585
relation: main_file
success: 1
file_date_updated: 2022-07-25T07:38:49Z
fulldoi: https://doi.org/10.1371/journal.pbio.3001684
has_accepted_license: '1'
intvolume: ' 20'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 23870BE8-32DE-11EA-91FC-C7463DDC885E
grant_number: 209504/A/17/Z
name: Molecular mechanisms of neural circuit function
publication: PLoS Biology
publication_identifier:
eissn:
- 1545-7885
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: ROS and cGMP signaling modulate persistent escape from hypoxia in Caenorhabditis
elegans
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 20
year: '2022'
...
---
_id: '12275'
abstract:
- lang: eng
text: N-glycans are molecularly diverse sugars borne by over 70% of proteins transiting
the secretory pathway and have been implicated in protein folding, stability,
and localization. Mutations in genes important for N-glycosylation result in congenital
disorders of glycosylation that are often associated with intellectual disability.
Here, we show that structurally distinct N-glycans regulate an extracellular protein
complex involved in the patterning of somatosensory dendrites in Caenorhabditis
elegans. Specifically, aman-2/Golgi alpha-mannosidase II, a conserved key enzyme
in the biosynthesis of specific N-glycans, regulates the activity of the Menorin
adhesion complex without obviously affecting the protein stability and localization
of its components. AMAN-2 functions cell-autonomously to allow for decoration
of the neuronal transmembrane receptor DMA-1/LRR-TM with the correct set of high-mannose/hybrid/paucimannose
N-glycans. Moreover, distinct types of N-glycans on specific N-glycosylation sites
regulate DMA-1/LRR-TM receptor function, which, together with three other extracellular
proteins, forms the Menorin adhesion complex. In summary, specific N-glycan structures
regulate dendrite patterning by coordinating the activity of an extracellular
adhesion complex, suggesting that the molecular diversity of N-glycans can contribute
to developmental specificity in the nervous system.
acknowledgement: 'We thank Scott Garforth, Sarah Garrett, Peri Kurshan, Yehuda Salzberg,
PamelaStanley, Robert Townley, and members of the B€ulow laboratory for commentson
the manuscript or helpful discussions during the course of this work. Wethank David
Miller, Shohei Mitani, Kang Shen, and Iain Wilson for reagents,and Yuji Kohara for
theyk11g705cDNA clone. We are grateful to MeeraTrivedi for sharing thedzIs117strain
prior to publication. Some strains wereprovided by the Caenorhabditis Genome Center
(funded by the NIH Office ofResearch Infrastructure Programs P40OD010440). This
work was supportedby grants from the National Institute of Health (NIH): R01NS096672andR21NS111145to
HEB; F31NS100370to MR; T32GM007288and F31HD066967to CADB; P30HD071593to Albert Einstein
College of Medicine. We acknowl-edge support to MR by the Department of Neuroscience.
NJRS was the recipi-ent of a Colciencias-Fulbright Fellowship and HEB of an Irma
T. Hirschl/Monique Weill-Caulier research fellowship'
article_number: e54163
article_processing_charge: No
article_type: original
author:
- first_name: Maisha
full_name: Rahman, Maisha
last_name: Rahman
- first_name: Nelson
full_name: Ramirez, Nelson
id: 39831956-E4FE-11E9-85DE-0DC7E5697425
last_name: Ramirez
- first_name: Carlos A
full_name: Diaz‐Balzac, Carlos A
last_name: Diaz‐Balzac
- first_name: Hannes E
full_name: Bülow, Hannes E
last_name: Bülow
citation:
ama: Rahman M, Ramirez N, Diaz‐Balzac CA, Bülow HE. Specific N-glycans regulate
an extracellular adhesion complex during somatosensory dendrite patterning. EMBO
Reports. 2022;23(7). doi:10.15252/embr.202154163
apa: Rahman, M., Ramirez, N., Diaz‐Balzac, C. A., & Bülow, H. E. (2022). Specific
N-glycans regulate an extracellular adhesion complex during somatosensory dendrite
patterning. EMBO Reports. Embo Press. https://doi.org/10.15252/embr.202154163
chicago: Rahman, Maisha, Nelson Ramirez, Carlos A Diaz‐Balzac, and Hannes E Bülow.
“Specific N-Glycans Regulate an Extracellular Adhesion Complex during Somatosensory
Dendrite Patterning.” EMBO Reports. Embo Press, 2022. https://doi.org/10.15252/embr.202154163.
ieee: M. Rahman, N. Ramirez, C. A. Diaz‐Balzac, and H. E. Bülow, “Specific N-glycans
regulate an extracellular adhesion complex during somatosensory dendrite patterning,”
EMBO Reports, vol. 23, no. 7. Embo Press, 2022.
ista: Rahman M, Ramirez N, Diaz‐Balzac CA, Bülow HE. 2022. Specific N-glycans regulate
an extracellular adhesion complex during somatosensory dendrite patterning. EMBO
Reports. 23(7), e54163.
mla: Rahman, Maisha, et al. “Specific N-Glycans Regulate an Extracellular Adhesion
Complex during Somatosensory Dendrite Patterning.” EMBO Reports, vol. 23,
no. 7, e54163, Embo Press, 2022, doi:10.15252/embr.202154163.
short: M. Rahman, N. Ramirez, C.A. Diaz‐Balzac, H.E. Bülow, EMBO Reports 23 (2022).
date_created: 2023-01-16T10:01:44Z
date_published: 2022-07-05T00:00:00Z
date_updated: 2026-06-18T17:26:25Z
day: '05'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.15252/embr.202154163
external_id:
isi:
- '000797302700001'
pmid:
- '35586945'
fulldoi: https://doi.org/10.15252/embr.202154163
has_accepted_license: '1'
intvolume: ' 23'
isi: 1
issue: '7'
keyword:
- Genetics
- Molecular Biology
- Biochemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.15252/embr.202154163
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: EMBO Reports
publication_identifier:
eissn:
- 1469-3178
issn:
- 1469-221X
publication_status: published
publisher: Embo Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Specific N-glycans regulate an extracellular adhesion complex during somatosensory
dendrite patterning
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2022'
...
---
_id: '15272'
abstract:
- lang: eng
text: The assembly of neuronal circuits involves the migrations of neurons from
their place of birth to their final location in the nervous system, as well as
the coordinated growth and patterning of axons and dendrites. In screens for genes
required for patterning of the nervous system, we identified the catp-8/P5A-ATPase
as an important regulator of neural patterning. P5A-ATPases are part of the P-type
ATPases, a family of proteins known to serve a conserved function as transporters
of ions, lipids and polyamines in unicellular eukaryotes, plants, and humans.
While the function of many P-type ATPases is relatively well understood, the function
of P5A-ATPases in metazoans remained elusive. We show here, that the Caenorhabditis
elegans ortholog catp-8/P5A-ATPase is
required for defined aspects of nervous system development. Specifically, the
catp-8/P5A-ATPase serves functions in shaping the elaborately
sculpted dendritic trees of somatosensory PVD neurons. Moreover, catp-8/P5A-ATPase
is required for axonal guidance and repulsion at the midline, as well as embryonic
and postembryonic neuronal migrations. Interestingly, not all axons at the midline
require catp-8/P5A-ATPase, although the axons run in
the same fascicles and navigate the same space. Similarly, not all neuronal migrations
require catp-8/P5A-ATPase. A CATP-8/P5A-ATPase reporter
is localized to the ER in most, if not all, tissues and catp-8/P5A-ATPase
can function both cell-autonomously and non-autonomously to regulate neuronal
development. Genetic analyses establish that catp-8/P5A-ATPase
can function in multiple pathways, including the Menorin pathway, previously shown
to control dendritic patterning in PVD, and Wnt signaling, which functions to
control neuronal migrations. Lastly, we show that catp-8/P5A-ATPase
is required for localizing select transmembrane proteins necessary for dendrite
morphogenesis. Collectively, our studies suggest that catp-8/P5A-ATPase
serves diverse, yet specific, roles in different genetic pathways and may be involved
in the regulation or localization of transmembrane and secreted proteins to specific
subcellular compartments.
article_number: e1009475
article_processing_charge: No
article_type: original
author:
- first_name: Leo T. H.
full_name: Tang, Leo T. H.
last_name: Tang
- first_name: Meera
full_name: Trivedi, Meera
last_name: Trivedi
- first_name: Jenna
full_name: Freund, Jenna
last_name: Freund
- first_name: Christopher J.
full_name: Salazar, Christopher J.
last_name: Salazar
- first_name: Maisha
full_name: Rahman, Maisha
last_name: Rahman
- first_name: Nelson
full_name: Ramirez, Nelson
id: 39831956-E4FE-11E9-85DE-0DC7E5697425
last_name: Ramirez
- first_name: Garrett
full_name: Lee, Garrett
last_name: Lee
- first_name: Yu
full_name: Wang, Yu
last_name: Wang
- first_name: Barth D.
full_name: Grant, Barth D.
last_name: Grant
- first_name: Hannes E.
full_name: Bülow, Hannes E.
last_name: Bülow
citation:
ama: Tang LTH, Trivedi M, Freund J, et al. The CATP-8/P5A-type ATPase functions
in multiple pathways during neuronal patterning. PLOS Genetics. 2021;17(7).
doi:10.1371/journal.pgen.1009475
apa: Tang, L. T. H., Trivedi, M., Freund, J., Salazar, C. J., Rahman, M., Ramirez,
N., … Bülow, H. E. (2021). The CATP-8/P5A-type ATPase functions in multiple pathways
during neuronal patterning. PLOS Genetics. Public Library of Science. https://doi.org/10.1371/journal.pgen.1009475
chicago: Tang, Leo T. H., Meera Trivedi, Jenna Freund, Christopher J. Salazar, Maisha
Rahman, Nelson Ramirez, Garrett Lee, Yu Wang, Barth D. Grant, and Hannes E. Bülow.
“The CATP-8/P5A-Type ATPase Functions in Multiple Pathways during Neuronal Patterning.”
PLOS Genetics. Public Library of Science, 2021. https://doi.org/10.1371/journal.pgen.1009475.
ieee: L. T. H. Tang et al., “The CATP-8/P5A-type ATPase functions in multiple
pathways during neuronal patterning,” PLOS Genetics, vol. 17, no. 7. Public
Library of Science, 2021.
ista: Tang LTH, Trivedi M, Freund J, Salazar CJ, Rahman M, Ramirez N, Lee G, Wang
Y, Grant BD, Bülow HE. 2021. The CATP-8/P5A-type ATPase functions in multiple
pathways during neuronal patterning. PLOS Genetics. 17(7), e1009475.
mla: Tang, Leo T. H., et al. “The CATP-8/P5A-Type ATPase Functions in Multiple Pathways
during Neuronal Patterning.” PLOS Genetics, vol. 17, no. 7, e1009475, Public
Library of Science, 2021, doi:10.1371/journal.pgen.1009475.
short: L.T.H. Tang, M. Trivedi, J. Freund, C.J. Salazar, M. Rahman, N. Ramirez,
G. Lee, Y. Wang, B.D. Grant, H.E. Bülow, PLOS Genetics 17 (2021).
date_created: 2024-04-03T07:57:12Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2024-04-10T08:57:16Z
day: '01'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1371/journal.pgen.1009475
external_id:
pmid:
- '34197450'
file:
- access_level: open_access
checksum: 7352b195e4db6d404f702fe6ad8b55ad
content_type: application/pdf
creator: dernst
date_created: 2024-04-10T08:53:43Z
date_updated: 2024-04-10T08:53:43Z
file_id: '15308'
file_name: 2021_PlosGenetics_Tang.pdf
file_size: 4224934
relation: main_file
success: 1
file_date_updated: 2024-04-10T08:53:43Z
fulldoi: https://doi.org/10.1371/journal.pgen.1009475
has_accepted_license: '1'
intvolume: ' 17'
issue: '7'
keyword:
- Cancer Research
- Genetics (clinical)
- Genetics
- Molecular Biology
- Ecology
- Evolution
- Behavior and Systematics
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLOS Genetics
publication_identifier:
issn:
- 1553-7404
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
status: public
title: The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2021'
...