[{"publisher":"Oxford University Press","OA_type":"hybrid","publication":"Evolution","ddc":["570"],"citation":{"ieee":"B. Wu and C. C. Guet, “Responsive lysogeny under nonproductive phage binding,” <i>Evolution</i>, vol. 80, no. 6. Oxford University Press, pp. 1365–1373, 2026.","ama":"Wu B, Guet CC. Responsive lysogeny under nonproductive phage binding. <i>Evolution</i>. 2026;80(6):1365-1373. doi:<a href=\"https://doi.org/10.1093/evolut/qpag061\">10.1093/evolut/qpag061</a>","ista":"Wu B, Guet CC. 2026. Responsive lysogeny under nonproductive phage binding. Evolution. 80(6), 1365–1373.","apa":"Wu, B., &#38; Guet, C. C. (2026). Responsive lysogeny under nonproductive phage binding. <i>Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/evolut/qpag061\">https://doi.org/10.1093/evolut/qpag061</a>","chicago":"Wu, Bryan, and Calin C Guet. “Responsive Lysogeny under Nonproductive Phage Binding.” <i>Evolution</i>. Oxford University Press, 2026. <a href=\"https://doi.org/10.1093/evolut/qpag061\">https://doi.org/10.1093/evolut/qpag061</a>.","short":"B. Wu, C.C. Guet, Evolution 80 (2026) 1365–1373.","mla":"Wu, Bryan, and Calin C. Guet. “Responsive Lysogeny under Nonproductive Phage Binding.” <i>Evolution</i>, vol. 80, no. 6, Oxford University Press, 2026, pp. 1365–73, doi:<a href=\"https://doi.org/10.1093/evolut/qpag061\">10.1093/evolut/qpag061</a>."},"intvolume":"        80","date_created":"2026-06-10T07:38:12Z","page":"1365-1373","volume":80,"publication_identifier":{"eissn":["1558-5646"],"issn":["0014-3820"]},"article_type":"original","related_material":{"link":[{"url":"https://github.com/theguetlab/responsive-lysogeny","relation":"software"}]},"date_updated":"2026-06-16T12:46:02Z","oa":1,"oa_version":"Published Version","acknowledgement":"We thank Fyodor Kondrashov and Gašper Tkačik for valuable input and guidance in building the model, and Stephen Abedon as well as the two anonymous reviewers for the comments provided on the manuscript.","pmid":1,"status":"public","issue":"6","file_date_updated":"2026-06-16T12:45:09Z","scopus_import":"1","type":"journal_article","_id":"21985","OA_place":"publisher","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Upon infecting a bacterial cell, temperate phages make a decision between lysis and lysogeny. While research has previously explored how phages sense environmental information to make this choice, most studies have focused on modelling known mechanisms that impact the decision. These mechanisms tell us what environmental information the phage does respond to, but not what it should respond to, as the signals sensed by the phage may serve as proxies for other sources of information. Here, using a mechanism-agnostic population dynamics model, we find that irreversible phage binding to lysogens protects sensitive host cells from infection. This results in lysogens being an additional environmental factor that the phage should sense while making its decision to undergo lysis or lysogeny. Using this model, we derive a responsive lysogeny probability for phages that respond to both cell and lysogen densities optimized towards invading phage-occupied systems, and show that it is more capable of invading and resisting invasion than phage with fixed lysogeny probabilities across different environmental conditions."}],"month":"06","language":[{"iso":"eng"}],"external_id":{"pmid":["41968110"]},"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"PlanS_conform":"1","date_published":"2026-06-01T00:00:00Z","day":"01","author":[{"id":"3C521EBA-F248-11E8-B48F-1D18A9856A87","last_name":"Wu","full_name":"Wu, Bryan","first_name":"Bryan"},{"full_name":"Guet, Calin C","first_name":"Calin C","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6220-2052","last_name":"Guet"}],"license":"https://creativecommons.org/licenses/by/4.0/","article_processing_charge":"Yes (via OA deal)","corr_author":"1","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2026","title":"Responsive lysogeny under nonproductive phage binding","department":[{"_id":"CaGu"}],"file":[{"success":1,"file_size":2077781,"date_created":"2026-06-16T12:45:09Z","relation":"main_file","checksum":"6d0f48566a7a36cb0c469e1968c9cb1c","content_type":"application/pdf","access_level":"open_access","file_id":"22015","file_name":"2026_Evolution_Wu.pdf","date_updated":"2026-06-16T12:45:09Z","creator":"dernst"}],"doi":"10.1093/evolut/qpag061","quality_controlled":"1"},{"file_date_updated":"2026-04-30T22:30:02Z","status":"public","language":[{"iso":"eng"}],"month":"10","has_accepted_license":"1","_id":"20470","OA_place":"publisher","abstract":[{"text":"Systems design has classically relied on composable systems, in which individual subsystems\r\nhave defined inputs, outputs, and interactions with each other; however, attempts at\r\ndesigning complex systems in synthetic biology has often run in to issues of crosstalk and\r\ninterference, given that these systems must function within the context of the host. In nature,\r\nmobile genetic elements are systems that have evolved to travel between hosts, and thus\r\nappear to be a good candidate with which to evaluate composability. Selecting temperate\r\nphages as a model system, I used mathematical modelling to identify sources of information\r\nthat temperate phages should respond to. I found that essential proteins of temperate phages\r\ncan interfere with potential hosts, indicating limitations to composability. I also designed a\r\nlysogeny reporter construct and characterize its behavior across various laboratory and\r\nenvironmental strains, finding differences in phage lambda lysogens, and potential\r\ninterference from prophages that already exist within the environmental strains. Although\r\nthe information gathered is not conclusive, it suggests that composability is not a key property\r\nof temperate phages, implying that biological systems may not be composable, and that other\r\nsystem design principles should be considered when designing synthetic systems.","lang":"eng"}],"type":"dissertation","publication_identifier":{"issn":["2663-337X"]},"page":"102","publisher":"Institute of Science and Technology Austria","citation":{"short":"B. Wu, An Examination on Phages as a Naturally Composable System, Institute of Science and Technology Austria, 2025.","mla":"Wu, Bryan. <i>An Examination on Phages as a Naturally Composable System</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20470\">10.15479/AT-ISTA-20470</a>.","ama":"Wu B. An examination on phages as a naturally composable system. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20470\">10.15479/AT-ISTA-20470</a>","ieee":"B. Wu, “An examination on phages as a naturally composable system,” Institute of Science and Technology Austria, 2025.","ista":"Wu B. 2025. An examination on phages as a naturally composable system. Institute of Science and Technology Austria.","chicago":"Wu, Bryan. “An Examination on Phages as a Naturally Composable System.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20470\">https://doi.org/10.15479/AT-ISTA-20470</a>.","apa":"Wu, B. (2025). <i>An examination on phages as a naturally composable system</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20470\">https://doi.org/10.15479/AT-ISTA-20470</a>"},"date_created":"2025-10-15T13:30:21Z","ddc":["579"],"oa_version":"Published Version","alternative_title":["ISTA Thesis"],"date_updated":"2026-05-06T08:01:28Z","oa":1,"file":[{"file_id":"20516","access_level":"closed","file_name":"2025_Wu_Bryan_Thesis.docx","creator":"brwu","date_updated":"2026-04-30T22:30:02Z","file_size":10603235,"checksum":"d32ea83f259f6b0506325cd57b1d44c3","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2025-10-21T17:33:27Z","relation":"source_file","embargo_to":"open_access"},{"file_size":6251936,"date_created":"2025-10-21T17:33:26Z","relation":"main_file","checksum":"53590046fd3244c5550b4022282449d2","content_type":"application/pdf","embargo":"2026-04-30","access_level":"open_access","file_id":"20517","file_name":"2025_Wu_Bryan_Thesis.pdf","date_updated":"2026-04-30T22:30:02Z","creator":"brwu"}],"department":[{"_id":"GradSch"},{"_id":"CaGu"}],"supervisor":[{"first_name":"Calin C","full_name":"Guet, Calin C","last_name":"Guet","orcid":"0000-0001-6220-2052","id":"47F8433E-F248-11E8-B48F-1D18A9856A87"}],"title":"An examination on phages as a naturally composable system","degree_awarded":"PhD","doi":"10.15479/AT-ISTA-20470","article_processing_charge":"No","corr_author":"1","day":"30","author":[{"id":"3C521EBA-F248-11E8-B48F-1D18A9856A87","last_name":"Wu","full_name":"Wu, Bryan","first_name":"Bryan"}],"date_published":"2025-10-30T00:00:00Z","year":"2025","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publication_status":"published"}]