[{"OA_place":"publisher","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"acknowledgement":"We thank F. Freeman, V. Voronin and M. Ladron de Guevara for technical assistance; A. Stichelberger and S. Liegenfeld for the management of our animal colony; M. Schunn, C. Gold and the Preclinical Facility team for technical assistance; C. Jansen and the Scientific Computing Facility for bioinformatics support and technical assistance; the Biomedical Sequencing Facility at CeMM for assistance with next-generation sequencing; and J. Lin and T. Krausgruber in the laboratory of C. Bock for support with flow cytometry; J. Kirchner for illustrating the multi-omics approach depicted in Fig. 1; and all members of the laboratory of G.N. for their support and discussions. This study was supported by the Scientific Service Units of ISTA through resources provided by the Imaging & Optics Facility and the Laboratory Support Facility. Bulk RNA-seq was performed by the Next Generation Sequencing Facility at Vienna BioCenter Core Facilities, member of the Vienna BioCenter. This work was supported by a European Research Council Consolidator Grant (PR1028ERC02), by SFARI (PR1028SIM02) and by the Austrian Science Fund (PE1028W1232 and PR1028FG1803) to G.N. Open access funding provided by Institute of Science and Technology (IST Austria).","external_id":{"pmid":["42310454"]},"date_published":"2026-06-17T00:00:00Z","pmid":1,"supplementarymaterial":"yes","has_accepted_license":"1","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publisher":"Springer Nature","citation":{"apa":"Schwarz, L. A., Dotter, C., Isaev, S., Lisi, M., Malzl, D., Büschl, C., … Novarino, G. (2026). Cortical development dynamics across autism spectrum disorder mouse models. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-026-10679-1\">https://doi.org/10.1038/s41586-026-10679-1</a>","short":"L.A. Schwarz, C. Dotter, S. Isaev, M. Lisi, D. Malzl, C. Büschl, S. Ladstätter, B. Oliveira, M. Barel, B. Basilico, C. Chintaluri, S. Gorkiewicz, M. Goudarzi, T. Belinova, S. Reichl, G. Sendžikaitė, S. Arcot Jayaram, P. Koppensteiner, C.M. Sommer, T.P. Vogels, J. Menche, I. Adameyko, P.V. Kharchenko, C. Bock, G. Novarino, Nature (2026).","chicago":"Schwarz, Lena A, Christoph Dotter, Sergey Isaev, Michela Lisi, Daniel Malzl, Christoph Büschl, Sabrina Ladstätter, et al. “Cortical Development Dynamics across Autism Spectrum Disorder Mouse Models.” <i>Nature</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41586-026-10679-1\">https://doi.org/10.1038/s41586-026-10679-1</a>.","ieee":"L. A. Schwarz <i>et al.</i>, “Cortical development dynamics across autism spectrum disorder mouse models,” <i>Nature</i>. Springer Nature, 2026.","ista":"Schwarz LA, Dotter C, Isaev S, Lisi M, Malzl D, Büschl C, Ladstätter S, Oliveira B, Barel M, Basilico B, Chintaluri C, Gorkiewicz S, Goudarzi M, Belinova T, Reichl S, Sendžikaitė G, Arcot Jayaram S, Koppensteiner P, Sommer CM, Vogels TP, Menche J, Adameyko I, Kharchenko PV, Bock C, Novarino G. 2026. Cortical development dynamics across autism spectrum disorder mouse models. Nature.","mla":"Schwarz, Lena A., et al. “Cortical Development Dynamics across Autism Spectrum Disorder Mouse Models.” <i>Nature</i>, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41586-026-10679-1\">10.1038/s41586-026-10679-1</a>.","ama":"Schwarz LA, Dotter C, Isaev S, et al. Cortical development dynamics across autism spectrum disorder mouse models. <i>Nature</i>. 2026. doi:<a href=\"https://doi.org/10.1038/s41586-026-10679-1\">10.1038/s41586-026-10679-1</a>"},"corr_author":"1","abstract":[{"text":"Despite the functional diversity of over 100 causal genes1,2,3, phenotypic convergence across models may reveal common neurobiological processes in autism spectrum disorder (ASD). Here we profiled 251 samples from 11 monogenic mouse models of ASD using single-nucleus multi-omic sequencing across three developmental stages, both sexes and two brain regions. Despite genetic heterogeneity, ASD-linked mutations converged on perturbations of the radial glial cell lineage. These alterations reflect a transient developmental delay rather than lasting lineage misspecification and resolve by postnatal stages. Molecularly, the largest transcriptional differences emerged in neurons at early postnatal stages. These changes included downregulation of synaptic and ion channel-related genes, consistent with homeostatic adaptation or delayed maturation. Network analysis showed molecular convergence across models within each developmental stage, suggesting that diverse mutations linked to ASD impinge on common, stage-specific processes. Convergence becomes less pronounced by postnatal day 14, highlighting the dynamic nature of ASD-associated changes. Cross-genotype heterogeneity is superimposed on stage-specific effects. Electrophysiology corroborated this pattern: mutants generally showed altered neuronal excitability and synaptic properties with model-specific nuances. Our study also highlighted sex-specific gene expression alterations, with female mice often displaying larger effect sizes than male mice. Together, our findings provide a comprehensive view of developmental cellular and molecular dynamics across models of ASD.","lang":"eng"}],"publication":"Nature","main_file_link":[{"url":"https://doi.org/10.1038/s41586-026-10679-1","open_access":"1"}],"oa":1,"month":"06","author":[{"last_name":"Schwarz","first_name":"Lena A","id":"29A8453C-F248-11E8-B48F-1D18A9856A87","full_name":"Schwarz, Lena A"},{"full_name":"Dotter, Christoph","last_name":"Dotter","first_name":"Christoph","orcid":"0000-0002-9033-9096","id":"4C66542E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Sergey","last_name":"Isaev","full_name":"Isaev, Sergey"},{"first_name":"Michela","last_name":"Lisi","id":"39383c1b-d3eb-11ef-8d6c-c8cdf4e10c8c","full_name":"Lisi, Michela"},{"last_name":"Malzl","first_name":"Daniel","full_name":"Malzl, Daniel"},{"id":"2a8c054c-0913-11ee-9159-f8ef515809ed","last_name":"Büschl","first_name":"Christoph","full_name":"Büschl, Christoph"},{"full_name":"Ladstätter, Sabrina","last_name":"Ladstätter","first_name":"Sabrina"},{"id":"3B03AA1A-F248-11E8-B48F-1D18A9856A87","last_name":"Oliveira","first_name":"Bárbara","full_name":"Oliveira, Bárbara"},{"full_name":"Barel, Matteo","last_name":"Barel","first_name":"Matteo","id":"8959927b-2236-11ed-bd6e-ea83d94ade0e"},{"last_name":"Basilico","first_name":"Bernadette","id":"36035796-5ACA-11E9-A75E-7AF2E5697425","orcid":"0000-0003-1843-3173","full_name":"Basilico, Bernadette"},{"last_name":"Chintaluri","first_name":"Chaitanya","id":"BA06AFEE-A4BA-11EA-AE5C-14673DDC885E","orcid":"0000-0003-4252-1608","full_name":"Chintaluri, Chaitanya"},{"full_name":"Gorkiewicz, Sarah","id":"f141a35d-15a9-11ec-9fb2-fef6becc7b6f","first_name":"Sarah","last_name":"Gorkiewicz"},{"first_name":"Mohammad","last_name":"Goudarzi","id":"3384113A-F248-11E8-B48F-1D18A9856A87","full_name":"Goudarzi, Mohammad"},{"id":"0bf89b6a-d28b-11eb-8bd6-f43768e4d368","first_name":"Tereza","last_name":"Belinova","full_name":"Belinova, Tereza"},{"last_name":"Reichl","first_name":"Stephan","full_name":"Reichl, Stephan"},{"id":"dd6d52f2-c50d-11eb-9548-bcf0ff82b344","first_name":"Gintarė","last_name":"Sendžikaitė","full_name":"Sendžikaitė, Gintarė"},{"full_name":"Arcot Jayaram, Satish","last_name":"Arcot Jayaram","first_name":"Satish","orcid":"0000-0002-2479-2669","id":"b0bbee33-09f7-11eb-909c-8b358058d28a"},{"first_name":"Peter","last_name":"Koppensteiner","orcid":"0000-0002-3509-1948","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","full_name":"Koppensteiner, Peter"},{"full_name":"Sommer, Christoph M","first_name":"Christoph M","last_name":"Sommer","orcid":"0000-0003-1216-9105","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Vogels, Tim P","first_name":"Tim P","last_name":"Vogels","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","orcid":"0000-0003-3295-6181"},{"first_name":"Jörg","last_name":"Menche","full_name":"Menche, Jörg"},{"first_name":"Igor","last_name":"Adameyko","full_name":"Adameyko, Igor"},{"full_name":"Kharchenko, Peter Vasili","last_name":"Kharchenko","first_name":"Peter Vasili","id":"0095641e-7eb7-11f1-8665-aec51a2ab5e0"},{"full_name":"Bock, Christoph","first_name":"Christoph","last_name":"Bock"},{"full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","last_name":"Novarino","first_name":"Gaia"}],"dataavailabilitystatement":"Single-nucleus multiomics data are available from the Gene Expression Omnibus (GSE328363). The mm10 reference genome was used for the alignment (refdata-cellranger-arc-mm10-2020-A-2.0.0, obtained from https://cf.10xgenomics.com/supp/cell-arc/refdata-cellranger-arc-mm10-2020-A-2.0.0.tar.gz). Single-cell data can be accessed and visualized through a CELLxGENE database (https://adameykolab.hifo.meduniwien.ac.at/cellxgene_public/filecrawl/.2026_Nature_Schwarz). Source data are provided with this paper. Scripts and analyses that support the main findings of this study are accessible in a GitHub repository (https://git.ista.ac.at/research-sofware/mouseome).","quality_controlled":"1","date_created":"2026-07-13T09:47:21Z","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"year":"2026","day":"17","language":[{"iso":"eng"}],"OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","_id":"22295","ddc":["570"],"publication_status":"epub_ahead","status":"public","date_updated":"2026-07-13T12:58:19Z","scopus_import":"1","doi":"10.1038/s41586-026-10679-1","project":[{"name":"Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders","grant_number":"101044865","_id":"34ba8964-11ca-11ed-8bc3-e15864e7e9a6"},{"name":"Critical windows and reversibility of ASD associated with mutations in chromatin remodelers","grant_number":"707964","_id":"9B91375C-BA93-11EA-9121-9846C619BF3A"},{"_id":"2548AE96-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"W1232","name":"Molecular Drug Targets"},{"_id":"ebb38b5d-77a9-11ec-83b8-a42e08120a88","name":"Neurobiology of anxiety in autism spectrum disorders","grant_number":"FG1803 49015"}],"researchdata_availability":"yes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Cortical development dynamics across autism spectrum disorder mouse models","department":[{"_id":"AnKi"},{"_id":"GaNo"},{"_id":"TiVo"},{"_id":"ScienComp"},{"_id":"GradSch"},{"_id":"Bio"},{"_id":"PreCl"}],"PlanS_conform":"1","oa_version":"Published Version","type":"journal_article","article_type":"original"},{"OA_place":"publisher","publication_identifier":{"issn":["1433-7851"],"eissn":["1521-3773"]},"external_id":{"pmid":["42429166"]},"acknowledgement":"Funded by the European Union (ERC, C-HANCE, 101142915 to N.M.). Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council. This research was funded in full or in part by the Austrian Science Fund (FWF, 10.55776/P37182 to N.M.). The technical staff of the NMR Centre of the Faculty of Chemistry (University of Vienna) are acknowledged for crucial NMR measurements and expert advice with spectral analysis. The authors thank the Core Facility Crystal Structure Analysis (U. Vienna) for determination of the crystal structures. The authors are also grateful to the University of Vienna for its continued support of our research programs.\r\n\r\nOpen Access funding provided by Universität Wien.","date_published":"2026-07-10T00:00:00Z","pmid":1,"supplementarymaterial":"yes","das_tickbox":"1","has_accepted_license":"1","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publisher":"Wiley","citation":{"short":"A.K. Hofmeister, G. Iannelli, P. Angyal, A. Malandain, D. Kaiser, B. Maryasin, H. Kählig, M. Barel, G. Novarino, N. Maulide, Angewandte Chemie International Edition (2026).","chicago":"Hofmeister, Angela K., Giulia Iannelli, Péter Angyal, Augustin Malandain, Daniel Kaiser, Boris Maryasin, Hanspeter Kählig, Matteo Barel, Gaia Novarino, and Nuno Maulide. “Unified Synthesis of Unconventional α-Polyhalogenated Amines through Hydroaminoalkylation.” <i>Angewandte Chemie International Edition</i>. Wiley, 2026. <a href=\"https://doi.org/10.1002/anie.1233707\">https://doi.org/10.1002/anie.1233707</a>.","apa":"Hofmeister, A. K., Iannelli, G., Angyal, P., Malandain, A., Kaiser, D., Maryasin, B., … Maulide, N. (2026). Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation. <i>Angewandte Chemie International Edition</i>. Wiley. <a href=\"https://doi.org/10.1002/anie.1233707\">https://doi.org/10.1002/anie.1233707</a>","ieee":"A. K. Hofmeister <i>et al.</i>, “Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation,” <i>Angewandte Chemie International Edition</i>. Wiley, 2026.","ista":"Hofmeister AK, Iannelli G, Angyal P, Malandain A, Kaiser D, Maryasin B, Kählig H, Barel M, Novarino G, Maulide N. 2026. Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation. Angewandte Chemie International Edition., e1233707.","ama":"Hofmeister AK, Iannelli G, Angyal P, et al. Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation. <i>Angewandte Chemie International Edition</i>. 2026. doi:<a href=\"https://doi.org/10.1002/anie.1233707\">10.1002/anie.1233707</a>","mla":"Hofmeister, Angela K., et al. “Unified Synthesis of Unconventional α-Polyhalogenated Amines through Hydroaminoalkylation.” <i>Angewandte Chemie International Edition</i>, e1233707, Wiley, 2026, doi:<a href=\"https://doi.org/10.1002/anie.1233707\">10.1002/anie.1233707</a>."},"abstract":[{"text":"We report a unified method for the synthesis of α-polyhalomethyl amines from alkenes and alkynes, enabled by readily available hemiaminal reagents. This operationally simple transformation allows for the introduction of not only well-established CF3 and CF2H groups, but also the synthetically (and medicinally) underexplored CF2Cl and CFClH motifs—thereby broadening access to previously inaccessible chemical space of halogenated amine scaffolds. The method displays broad substrate scope and functional-group tolerance while operating under mild conditions. Late-stage functionalization of drug-like derivatives of Oxaprozin, Erlotinib, and Ibuprofen (among others) is reported.","lang":"eng"}],"publication":"Angewandte Chemie International Edition","month":"07","dataavailabilitystatement":"The data that supports the findings of this study are available in the supplementary material of this article.","author":[{"last_name":"Hofmeister","first_name":"Angela K.","full_name":"Hofmeister, Angela K."},{"last_name":"Iannelli","first_name":"Giulia","full_name":"Iannelli, Giulia"},{"last_name":"Angyal","first_name":"Péter","full_name":"Angyal, Péter"},{"full_name":"Malandain, Augustin","last_name":"Malandain","first_name":"Augustin"},{"full_name":"Kaiser, Daniel","first_name":"Daniel","last_name":"Kaiser"},{"full_name":"Maryasin, Boris","last_name":"Maryasin","first_name":"Boris"},{"full_name":"Kählig, Hanspeter","last_name":"Kählig","first_name":"Hanspeter"},{"full_name":"Barel, Matteo","id":"8959927b-2236-11ed-bd6e-ea83d94ade0e","last_name":"Barel","first_name":"Matteo"},{"orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia","last_name":"Novarino","full_name":"Novarino, Gaia"},{"full_name":"Maulide, Nuno","last_name":"Maulide","first_name":"Nuno"}],"quality_controlled":"1","date_created":"2026-07-19T22:01:48Z","year":"2026","day":"10","article_number":"e1233707","article_processing_charge":"Yes (via OA deal)","OA_type":"hybrid","language":[{"iso":"eng"}],"_id":"22370","ddc":["570","540"],"publication_status":"epub_ahead","status":"public","date_updated":"2026-07-21T07:19:26Z","doi":"10.1002/anie.1233707","scopus_import":"1","researchdata_availability":"no","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Unified synthesis of unconventional α-polyhalogenated amines through hydroaminoalkylation","department":[{"_id":"GaNo"},{"_id":"GradSch"}],"oa_version":"Published Version","type":"journal_article","article_type":"original"},{"abstract":[{"text":"Residents of low-latitude megacities face growing vulnerability to humid-heat stress under urbanization and global warming, yet limited research has assessed the morbidity burden of mental and behavioral disorders (MBDs) linked to humid-heat exposures in these cities. Here we quantify the hospital admissions of MBDs in Shanghai, a megacity of over 25 million inhabitants, attributable to humid heat, and project future burdens under various greenhouse gas (GHG)-emission and population scenarios. Humid heat drives a higher morbidity burden than high temperature alone, especially in humid-heat nights. Without population change, the humid-heat-related morbidity burden of MBDs would increase by 68.2% (95% empirical confidence interval 56.7%–81.6%) under the highest-GHG-emission scenario by the 2090s, while 8,465 (95% empirical confidence interval 6,928–10,053) cases would be avoided by reducing emissions to the lowest pathway. With projected population decline, the attributable hospital admissions will decrease toward century’s end. These findings highlight the benefit of GHG mitigation in reducing the growing MBD risks posed by extreme humid heat.","lang":"eng"}],"citation":{"ista":"Liang C, Yuan J, Zhang R, Tang X, Schumann G, Hitchen E, Polemiti E, Serin E, Kebir H, Lett TA, Vaidya N, Roy J-C, Walter H, Heinz A, Ralser M, Twardziok S, Eils R, Jentsch M, Taron U-H, Schütz T, Schepanski K, Banaschewski T, Neidhart M, Meyer-Lindenberg A, Tost H, Holz N, Schwarz E, Stringaris A, Christmann N, Janson K, Nees F, Neidhart M, Seefried B, Aden R, Andreassen OA, Westlye LT, van der Meer D, Fernández-Cabello S, Kjelkenes R, Ask H, Rapp M, Tschorn M, Böttger SJ, Marquand A, Bernas A, Novarino G, Slater M, Gallego J, Pastor Á, Feixas G, Eiroa-Orosa FJ, Nöthen MM, Forstner AJ, Claus I, Mathey C, Heilmann-Heimbach S, Hoffmann P, Miller A, Sommer P, Schmitt K, Wilbertz J, Patraskaki M, Jirsa V, Petkoski S, Athanasiadis A-P, Spanlang B, Pearmund C, Hese S, Renner P, Jia T, Chang X, Dai Y, Xia Y, Li Y, Zhang Y, Calhoun V, Thompson P, Clinton N, Desrivières S, Agunbiade K, Yu X, Zhang Z, Chen D, Young AH, Schwalber A, Köhler V, Stahl B, Ogoh G, Schikowski T, Brandlistuen R. 2025. Projecting the morbidity burden of mental and behavioral disorders associated with increasing humid heat in Shanghai. Nature Mental Health. 3(12), 1532–1544.","ama":"Liang C, Yuan J, Zhang R, et al. Projecting the morbidity burden of mental and behavioral disorders associated with increasing humid heat in Shanghai. <i>Nature Mental Health</i>. 2025;3(12):1532-1544. doi:<a href=\"https://doi.org/10.1038/s44220-025-00519-y\">10.1038/s44220-025-00519-y</a>","mla":"Liang, Chen, et al. “Projecting the Morbidity Burden of Mental and Behavioral Disorders Associated with Increasing Humid Heat in Shanghai.” <i>Nature Mental Health</i>, vol. 3, no. 12, Springer Nature, 2025, pp. 1532–44, doi:<a href=\"https://doi.org/10.1038/s44220-025-00519-y\">10.1038/s44220-025-00519-y</a>.","chicago":"Liang, Chen, Jiacan Yuan, Renhe Zhang, Xu Tang, Gunter Schumann, Esther Hitchen, Elli Polemiti, et al. “Projecting the Morbidity Burden of Mental and Behavioral Disorders Associated with Increasing Humid Heat in Shanghai.” <i>Nature Mental Health</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s44220-025-00519-y\">https://doi.org/10.1038/s44220-025-00519-y</a>.","short":"C. Liang, J. Yuan, R. Zhang, X. Tang, G. Schumann, E. Hitchen, E. Polemiti, E. Serin, H. Kebir, T.A. Lett, N. Vaidya, J.-C. Roy, H. Walter, A. Heinz, M. Ralser, S. Twardziok, R. Eils, M. Jentsch, U.-H. Taron, T. Schütz, K. Schepanski, T. Banaschewski, M. Neidhart, A. Meyer-Lindenberg, H. Tost, N. Holz, E. Schwarz, A. Stringaris, N. Christmann, K. Janson, F. Nees, M. Neidhart, B. Seefried, R. Aden, O.A. Andreassen, L.T. Westlye, D. van der Meer, S. Fernández-Cabello, R. Kjelkenes, H. Ask, M. Rapp, M. Tschorn, S.J. Böttger, A. Marquand, A. Bernas, G. Novarino, M. Slater, J. Gallego, Á. Pastor, G. Feixas, F.J. Eiroa-Orosa, M.M. Nöthen, A.J. Forstner, I. Claus, C. Mathey, S. Heilmann-Heimbach, P. Hoffmann, A. Miller, P. Sommer, K. Schmitt, J. Wilbertz, M. Patraskaki, V. Jirsa, S. Petkoski, A.-P. Athanasiadis, B. Spanlang, C. Pearmund, S. Hese, P. Renner, T. Jia, X. Chang, Y. Dai, Y. Xia, Y. Li, Y. Zhang, V. Calhoun, P. Thompson, N. Clinton, S. Desrivières, K. Agunbiade, X. Yu, Z. Zhang, D. Chen, A.H. Young, A. Schwalber, V. Köhler, B. Stahl, G. Ogoh, T. Schikowski, R. Brandlistuen, Nature Mental Health 3 (2025) 1532–1544.","apa":"Liang, C., Yuan, J., Zhang, R., Tang, X., Schumann, G., Hitchen, E., … Brandlistuen, R. (2025). Projecting the morbidity burden of mental and behavioral disorders associated with increasing humid heat in Shanghai. <i>Nature Mental Health</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s44220-025-00519-y\">https://doi.org/10.1038/s44220-025-00519-y</a>","ieee":"C. Liang <i>et al.</i>, “Projecting the morbidity burden of mental and behavioral disorders associated with increasing humid heat in Shanghai,” <i>Nature Mental Health</i>, vol. 3, no. 12. Springer Nature, pp. 1532–1544, 2025."},"publication":"Nature Mental Health","acknowledgement":"This research was supported by the National Natural Science Foundation of China (grants 42288101 and 42175066) and Shanghai International Science and Technology Partnership Project (grant 21230780200). G.S. is supported by the China Brain Project (grant 2025ZD0215100), the National Natural Science Foundation of China (grant 82150710554), the Chinese National Key Project (grant 2023YFE0199700), the National Natural Science Foundation of China (grant W2541022) and the EC Horizon Europe: environMENTAL project.","date_published":"2025-12-01T00:00:00Z","publication_identifier":{"issn":["2731-6076"]},"publisher":"Springer Nature","volume":3,"day":"01","year":"2025","date_created":"2025-12-29T12:11:28Z","quality_controlled":"1","author":[{"first_name":"Chen","last_name":"Liang","full_name":"Liang, Chen"},{"full_name":"Yuan, Jiacan","first_name":"Jiacan","last_name":"Yuan"},{"full_name":"Zhang, Renhe","last_name":"Zhang","first_name":"Renhe"},{"full_name":"Tang, Xu","first_name":"Xu","last_name":"Tang"},{"full_name":"Schumann, Gunter","first_name":"Gunter","last_name":"Schumann"},{"last_name":"Hitchen","first_name":"Esther","full_name":"Hitchen, Esther"},{"last_name":"Polemiti","first_name":"Elli","full_name":"Polemiti, Elli"},{"full_name":"Serin, Emin","last_name":"Serin","first_name":"Emin"},{"first_name":"Hedi","last_name":"Kebir","full_name":"Kebir, Hedi"},{"first_name":"Tristram A.","last_name":"Lett","full_name":"Lett, Tristram A."},{"full_name":"Vaidya, Nilakshi","last_name":"Vaidya","first_name":"Nilakshi"},{"full_name":"Roy, Jean-Charles","first_name":"Jean-Charles","last_name":"Roy"},{"last_name":"Walter","first_name":"Henrik","full_name":"Walter, Henrik"},{"full_name":"Heinz, Andreas","last_name":"Heinz","first_name":"Andreas"},{"full_name":"Ralser, Markus","first_name":"Markus","last_name":"Ralser"},{"last_name":"Twardziok","first_name":"Sven","full_name":"Twardziok, Sven"},{"first_name":"Roland","last_name":"Eils","full_name":"Eils, Roland"},{"last_name":"Jentsch","first_name":"Marcel","full_name":"Jentsch, Marcel"},{"full_name":"Taron, Ulrike-Helene","first_name":"Ulrike-Helene","last_name":"Taron"},{"full_name":"Schütz, Tatjana","last_name":"Schütz","first_name":"Tatjana"},{"full_name":"Schepanski, Kerstin","last_name":"Schepanski","first_name":"Kerstin"},{"full_name":"Banaschewski, Tobias","last_name":"Banaschewski","first_name":"Tobias"},{"full_name":"Neidhart, Maja","last_name":"Neidhart","first_name":"Maja"},{"last_name":"Meyer-Lindenberg","first_name":"Andreas","full_name":"Meyer-Lindenberg, Andreas"},{"first_name":"Heike","last_name":"Tost","full_name":"Tost, Heike"},{"last_name":"Holz","first_name":"Nathalie","full_name":"Holz, Nathalie"},{"last_name":"Schwarz","first_name":"Emanuel","full_name":"Schwarz, Emanuel"},{"first_name":"Argyris","last_name":"Stringaris","full_name":"Stringaris, Argyris"},{"last_name":"Christmann","first_name":"Nina","full_name":"Christmann, Nina"},{"full_name":"Janson, Karina","last_name":"Janson","first_name":"Karina"},{"full_name":"Nees, Frauke","last_name":"Nees","first_name":"Frauke"},{"first_name":"Maja","last_name":"Neidhart","full_name":"Neidhart, Maja"},{"full_name":"Seefried, Beke","last_name":"Seefried","first_name":"Beke"},{"full_name":"Aden, Rieke","first_name":"Rieke","last_name":"Aden"},{"last_name":"Andreassen","first_name":"Ole A.","full_name":"Andreassen, Ole A."},{"full_name":"Westlye, Lars T.","last_name":"Westlye","first_name":"Lars T."},{"full_name":"van der Meer, Dennis","first_name":"Dennis","last_name":"van der Meer"},{"full_name":"Fernández-Cabello, Sara","last_name":"Fernández-Cabello","first_name":"Sara"},{"full_name":"Kjelkenes, Rikka","last_name":"Kjelkenes","first_name":"Rikka"},{"last_name":"Ask","first_name":"Helga","full_name":"Ask, Helga"},{"first_name":"Michael","last_name":"Rapp","full_name":"Rapp, Michael"},{"last_name":"Tschorn","first_name":"Mira","full_name":"Tschorn, Mira"},{"full_name":"Böttger, Sarah Jane","first_name":"Sarah Jane","last_name":"Böttger"},{"full_name":"Marquand, Andre","first_name":"Andre","last_name":"Marquand"},{"first_name":"Antoine","last_name":"Bernas","full_name":"Bernas, Antoine"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","last_name":"Novarino","first_name":"Gaia","full_name":"Novarino, Gaia"},{"first_name":"Mel","last_name":"Slater","full_name":"Slater, Mel"},{"last_name":"Gallego","first_name":"Jaime","full_name":"Gallego, Jaime"},{"last_name":"Pastor","first_name":"Álvaro","full_name":"Pastor, Álvaro"},{"full_name":"Feixas, Guillem","last_name":"Feixas","first_name":"Guillem"},{"last_name":"Eiroa-Orosa","first_name":"Francisco José","full_name":"Eiroa-Orosa, Francisco José"},{"first_name":"Markus M.","last_name":"Nöthen","full_name":"Nöthen, Markus M."},{"full_name":"Forstner, Andreas J.","last_name":"Forstner","first_name":"Andreas J."},{"full_name":"Claus, Isabelle","last_name":"Claus","first_name":"Isabelle"},{"full_name":"Mathey, Carina","first_name":"Carina","last_name":"Mathey"},{"last_name":"Heilmann-Heimbach","first_name":"Stefanie","full_name":"Heilmann-Heimbach, Stefanie"},{"first_name":"Per","last_name":"Hoffmann","full_name":"Hoffmann, Per"},{"full_name":"Miller, Abigail","first_name":"Abigail","last_name":"Miller"},{"first_name":"Peter","last_name":"Sommer","full_name":"Sommer, Peter"},{"first_name":"Karen","last_name":"Schmitt","full_name":"Schmitt, Karen"},{"full_name":"Wilbertz, Johannes","last_name":"Wilbertz","first_name":"Johannes"},{"full_name":"Patraskaki, Myrto","first_name":"Myrto","last_name":"Patraskaki"},{"first_name":"Viktor","last_name":"Jirsa","full_name":"Jirsa, Viktor"},{"first_name":"Spase","last_name":"Petkoski","full_name":"Petkoski, Spase"},{"full_name":"Athanasiadis, Anastasios-Polykarpos","last_name":"Athanasiadis","first_name":"Anastasios-Polykarpos"},{"last_name":"Spanlang","first_name":"Bernhard","full_name":"Spanlang, Bernhard"},{"last_name":"Pearmund","first_name":"Charlie","full_name":"Pearmund, Charlie"},{"full_name":"Hese, Sören","first_name":"Sören","last_name":"Hese"},{"last_name":"Renner","first_name":"Paul","full_name":"Renner, Paul"},{"full_name":"Jia, Tianye","first_name":"Tianye","last_name":"Jia"},{"first_name":"Xiao","last_name":"Chang","full_name":"Chang, Xiao"},{"last_name":"Dai","first_name":"Yuxiang","full_name":"Dai, Yuxiang"},{"first_name":"Yunman","last_name":"Xia","full_name":"Xia, Yunman"},{"full_name":"Li, Yuzhu","first_name":"Yuzhu","last_name":"Li"},{"first_name":"Yanqing","last_name":"Zhang","full_name":"Zhang, Yanqing"},{"last_name":"Calhoun","first_name":"Vince","full_name":"Calhoun, Vince"},{"last_name":"Thompson","first_name":"Paul","full_name":"Thompson, Paul"},{"full_name":"Clinton, Nicholas","last_name":"Clinton","first_name":"Nicholas"},{"full_name":"Desrivières, Sylvane","last_name":"Desrivières","first_name":"Sylvane"},{"first_name":"Kofoworola","last_name":"Agunbiade","full_name":"Agunbiade, Kofoworola"},{"full_name":"Yu, Xinyang","first_name":"Xinyang","last_name":"Yu"},{"full_name":"Zhang, Zuo","last_name":"Zhang","first_name":"Zuo"},{"full_name":"Chen, Di","first_name":"Di","last_name":"Chen"},{"full_name":"Young, Allan H.","first_name":"Allan H.","last_name":"Young"},{"last_name":"Schwalber","first_name":"Ameli","full_name":"Schwalber, Ameli"},{"last_name":"Köhler","first_name":"Vanessa","full_name":"Köhler, Vanessa"},{"full_name":"Stahl, Bernd","last_name":"Stahl","first_name":"Bernd"},{"full_name":"Ogoh, George","last_name":"Ogoh","first_name":"George"},{"last_name":"Schikowski","first_name":"Tamara","full_name":"Schikowski, Tamara"},{"full_name":"Brandlistuen, Ragnhild","first_name":"Ragnhild","last_name":"Brandlistuen"}],"month":"12","date_updated":"2026-01-05T12:02:29Z","status":"public","issue":"12","publication_status":"published","doi":"10.1038/s44220-025-00519-y","scopus_import":"1","intvolume":"         3","_id":"20868","OA_type":"closed access","language":[{"iso":"eng"}],"article_processing_charge":"No","department":[{"_id":"GaNo"}],"title":"Projecting the morbidity burden of mental and behavioral disorders associated with increasing humid heat in Shanghai","article_type":"original","type":"journal_article","oa_version":"None","project":[{"name":"Reducing the impact of major environmental challenges on mental health","grant_number":"101057429","_id":"349d1832-11ca-11ed-8bc3-d79b574010e0"}],"page":"1532-1544","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"date_updated":"2025-09-30T11:13:47Z","status":"public","publication_status":"published","issue":"8054","doi":"10.1038/s41586-024-08487-6","scopus_import":"1","intvolume":"       639","_id":"19444","article_processing_charge":"No","OA_type":"closed access","language":[{"iso":"eng"}],"department":[{"_id":"GaNo"}],"title":"A framework for neural organoids, assembloids and transplantation studies","article_type":"original","type":"journal_article","oa_version":"None","page":"315-320","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","abstract":[{"lang":"eng","text":"As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models. In this Perspective, we present a framework for the experimental process that encompasses ensuring the quality and integrity of human pluripotent stem cells, characterizing and manipulating neural cells in vitro, transplantation techniques and considerations for modelling human development, evolution and disease. As with all scientific endeavours, we advocate for rigorous experimental designs tailored to explicit scientific questions as well as transparent methodologies and data sharing to provide useful knowledge for current research practices and for developing regulatory standards."}],"citation":{"ama":"Pașca SP, Arlotta P, Bateup HS, et al. A framework for neural organoids, assembloids and transplantation studies. <i>Nature</i>. 2025;639(8054):315-320. doi:<a href=\"https://doi.org/10.1038/s41586-024-08487-6\">10.1038/s41586-024-08487-6</a>","mla":"Pașca, Sergiu P., et al. “A Framework for Neural Organoids, Assembloids and Transplantation Studies.” <i>Nature</i>, vol. 639, no. 8054, Springer Nature, 2025, pp. 315–20, doi:<a href=\"https://doi.org/10.1038/s41586-024-08487-6\">10.1038/s41586-024-08487-6</a>.","ista":"Pașca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Novarino G, Okano H, Parmar M, Park IH, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino FM, Vanderhaeghen P, Young-Pearse T. 2025. A framework for neural organoids, assembloids and transplantation studies. Nature. 639(8054), 315–320.","ieee":"S. P. Pașca <i>et al.</i>, “A framework for neural organoids, assembloids and transplantation studies,” <i>Nature</i>, vol. 639, no. 8054. Springer Nature, pp. 315–320, 2025.","short":"S.P. Pașca, P. Arlotta, H.S. Bateup, J.G. Camp, S. Cappello, F.H. Gage, J.A. Knoblich, A.R. Kriegstein, M.A. Lancaster, G.L. Ming, G. Novarino, H. Okano, M. Parmar, I.H. Park, O. Reiner, H. Song, L. Studer, J. Takahashi, S. Temple, G. Testa, B. Treutlein, F.M. Vaccarino, P. Vanderhaeghen, T. Young-Pearse, Nature 639 (2025) 315–320.","chicago":"Pașca, Sergiu P., Paola Arlotta, Helen S. Bateup, J. Gray Camp, Silvia Cappello, Fred H. Gage, Jürgen A. Knoblich, et al. “A Framework for Neural Organoids, Assembloids and Transplantation Studies.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-024-08487-6\">https://doi.org/10.1038/s41586-024-08487-6</a>.","apa":"Pașca, S. P., Arlotta, P., Bateup, H. S., Camp, J. G., Cappello, S., Gage, F. H., … Young-Pearse, T. (2025). A framework for neural organoids, assembloids and transplantation studies. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-024-08487-6\">https://doi.org/10.1038/s41586-024-08487-6</a>"},"publication":"Nature","pmid":1,"date_published":"2025-03-13T00:00:00Z","acknowledgement":"The authors thank members of their laboratories who provided feedback on earlier versions of this manuscript, including A. Jourdon, V. Mariano, T. L. Li, N. Caporale, E. Villa and M. Sutcliffe.","external_id":{"pmid":["39653126"],"isi":["001437461900001"]},"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"publisher":"Springer Nature","isi":1,"volume":639,"day":"13","year":"2025","date_created":"2025-03-23T23:01:27Z","quality_controlled":"1","author":[{"first_name":"Sergiu P.","last_name":"Pașca","full_name":"Pașca, Sergiu P."},{"first_name":"Paola","last_name":"Arlotta","full_name":"Arlotta, Paola"},{"last_name":"Bateup","first_name":"Helen S.","full_name":"Bateup, Helen S."},{"last_name":"Camp","first_name":"J. Gray","full_name":"Camp, J. Gray"},{"first_name":"Silvia","last_name":"Cappello","full_name":"Cappello, Silvia"},{"last_name":"Gage","first_name":"Fred H.","full_name":"Gage, Fred H."},{"full_name":"Knoblich, Jürgen A.","last_name":"Knoblich","first_name":"Jürgen A."},{"full_name":"Kriegstein, Arnold R.","last_name":"Kriegstein","first_name":"Arnold R."},{"full_name":"Lancaster, Madeline A.","last_name":"Lancaster","first_name":"Madeline A."},{"last_name":"Ming","first_name":"Guo Li","full_name":"Ming, Guo Li"},{"full_name":"Novarino, Gaia","last_name":"Novarino","first_name":"Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Okano","first_name":"Hideyuki","full_name":"Okano, Hideyuki"},{"first_name":"Malin","last_name":"Parmar","full_name":"Parmar, Malin"},{"full_name":"Park, In Hyun","last_name":"Park","first_name":"In Hyun"},{"full_name":"Reiner, Orly","last_name":"Reiner","first_name":"Orly"},{"first_name":"Hongjun","last_name":"Song","full_name":"Song, Hongjun"},{"last_name":"Studer","first_name":"Lorenz","full_name":"Studer, Lorenz"},{"first_name":"Jun","last_name":"Takahashi","full_name":"Takahashi, Jun"},{"full_name":"Temple, Sally","first_name":"Sally","last_name":"Temple"},{"full_name":"Testa, Giuseppe","first_name":"Giuseppe","last_name":"Testa"},{"last_name":"Treutlein","first_name":"Barbara","full_name":"Treutlein, Barbara"},{"first_name":"Flora M.","last_name":"Vaccarino","full_name":"Vaccarino, Flora M."},{"full_name":"Vanderhaeghen, Pierre","first_name":"Pierre","last_name":"Vanderhaeghen"},{"last_name":"Young-Pearse","first_name":"Tracy","full_name":"Young-Pearse, Tracy"}],"month":"03"},{"oa":1,"related_material":{"link":[{"description":"News on ISTA website","url":"https://ista.ac.at/en/news/piecing-together-the-brain-puzzle/","relation":"press_release"}],"record":[{"relation":"earlier_version","id":"18677","status":"public"},{"status":"public","id":"18697","relation":"research_data"}]},"author":[{"full_name":"Tavakoli, Mojtaba","first_name":"Mojtaba","last_name":"Tavakoli","orcid":"0000-0002-7667-6854","id":"3A0A06F4-F248-11E8-B48F-1D18A9856A87"},{"id":"46E28B80-F248-11E8-B48F-1D18A9856A87","first_name":"Julia","last_name":"Lyudchik","full_name":"Lyudchik, Julia"},{"full_name":"Januszewski, Michał","first_name":"Michał","last_name":"Januszewski"},{"full_name":"Vistunou, Vitali","id":"7e146587-8972-11ed-ae7b-d7a32ea86a81","first_name":"Vitali","last_name":"Vistunou"},{"full_name":"Agudelo Duenas, Nathalie","first_name":"Nathalie","last_name":"Agudelo Duenas","id":"40E7F008-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Vorlaufer, Jakob","first_name":"Jakob","last_name":"Vorlaufer","orcid":"0009-0000-7590-3501","id":"937696FA-C996-11E9-8C7C-CF13E6697425"},{"full_name":"Sommer, Christoph M","last_name":"Sommer","first_name":"Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1216-9105"},{"full_name":"Kreuzinger, Caroline","id":"382077BA-F248-11E8-B48F-1D18A9856A87","last_name":"Kreuzinger","first_name":"Caroline"},{"full_name":"Oliveira, Bárbara","id":"3B03AA1A-F248-11E8-B48F-1D18A9856A87","first_name":"Bárbara","last_name":"Oliveira"},{"full_name":"Cenameri, Alban","last_name":"Cenameri","first_name":"Alban","id":"9ac8f577-2357-11eb-997a-e566c5550886"},{"full_name":"Novarino, Gaia","first_name":"Gaia","last_name":"Novarino","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Viren","last_name":"Jain","full_name":"Jain, Viren"},{"full_name":"Danzl, Johann G","last_name":"Danzl","first_name":"Johann G","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8559-3973"}],"quality_controlled":"1","month":"06","volume":642,"year":"2025","day":"12","date_created":"2025-05-18T22:02:51Z","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"ScienComp"},{"_id":"PreCl"},{"_id":"M-Shop"},{"_id":"E-Lib"}],"pmid":1,"OA_place":"publisher","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"external_id":{"pmid":["40335689"],"isi":["001483477000001"]},"date_published":"2025-06-12T00:00:00Z","acknowledgement":"We thank S. Dorkenwald and P. Li for critical reading of the manuscript, S. Loomba for discussions and E. Miguel for support with data handling. We acknowledge support from ISTA’s scientific service units: Imaging and Optics, Lab Support, Scientific Computing, the preclinical facility, the Miba Machine Shop and the library. We acknowledge funding from the following sources: Austrian Science Fund (FWF) grant DK W1232 (J.G.D. and M.R.T.); Austrian Academy of Sciences DOC fellowship 26137 (M.R.T.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); the European Union’s Horizon 2020 research and innovation programme and Marie Skłodowska-Curie Actions Fellowship 665385 (J.L.); and the European Union’s Horizon 2020 research and innovation programme and European Research Council (ERC) grant 101044865 ‘SecretAutism’ (G.N.).Open access funding provided by Institute of Science and Technology (IST Austria).","file_date_updated":"2025-07-03T06:55:20Z","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"isi":1,"publisher":"Springer Nature","has_accepted_license":"1","corr_author":"1","abstract":[{"lang":"eng","text":"The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric imaging at nanoscale resolution1,2 with dense cellular labelling. Light microscopy is uniquely positioned to visualize specific molecules, but dense, synapse-level circuit reconstruction by light microscopy has been out of reach, owing to limitations in resolution, contrast and volumetric imaging capability. Here we describe light-microscopy-based connectomics (LICONN). We integrated specifically engineered hydrogel embedding and expansion with comprehensive deep-learning-based segmentation and analysis of connectivity, thereby directly incorporating molecular information into synapse-level reconstructions of brain tissue. LICONN will allow synapse-level phenotyping of brain tissue in biological experiments in a readily adoptable manner."}],"citation":{"apa":"Tavakoli, M., Lyudchik, J., Januszewski, M., Vistunou, V., Agudelo Duenas, N., Vorlaufer, J., … Danzl, J. G. (2025). Light-microscopy-based connectomic reconstruction of mammalian brain tissue. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-025-08985-1\">https://doi.org/10.1038/s41586-025-08985-1</a>","short":"M. Tavakoli, J. Lyudchik, M. Januszewski, V. Vistunou, N. Agudelo Duenas, J. Vorlaufer, C.M. Sommer, C. Kreuzinger, B. Oliveira, A. Cenameri, G. Novarino, V. Jain, J.G. Danzl, Nature 642 (2025) 398–410.","chicago":"Tavakoli, Mojtaba, Julia Lyudchik, Michał Januszewski, Vitali Vistunou, Nathalie Agudelo Duenas, Jakob Vorlaufer, Christoph M Sommer, et al. “Light-Microscopy-Based Connectomic Reconstruction of Mammalian Brain Tissue.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-025-08985-1\">https://doi.org/10.1038/s41586-025-08985-1</a>.","ieee":"M. Tavakoli <i>et al.</i>, “Light-microscopy-based connectomic reconstruction of mammalian brain tissue,” <i>Nature</i>, vol. 642. Springer Nature, pp. 398–410, 2025.","ista":"Tavakoli M, Lyudchik J, Januszewski M, Vistunou V, Agudelo Duenas N, Vorlaufer J, Sommer CM, Kreuzinger C, Oliveira B, Cenameri A, Novarino G, Jain V, Danzl JG. 2025. Light-microscopy-based connectomic reconstruction of mammalian brain tissue. Nature. 642, 398–410.","mla":"Tavakoli, Mojtaba, et al. “Light-Microscopy-Based Connectomic Reconstruction of Mammalian Brain Tissue.” <i>Nature</i>, vol. 642, Springer Nature, 2025, pp. 398–410, doi:<a href=\"https://doi.org/10.1038/s41586-025-08985-1\">10.1038/s41586-025-08985-1</a>.","ama":"Tavakoli M, Lyudchik J, Januszewski M, et al. Light-microscopy-based connectomic reconstruction of mammalian brain tissue. <i>Nature</i>. 2025;642:398-410. doi:<a href=\"https://doi.org/10.1038/s41586-025-08985-1\">10.1038/s41586-025-08985-1</a>"},"publication":"Nature","ec_funded":1,"project":[{"name":"Studying Organelle Structure and Function at Nanoscale Resolution with Expansion Microscopy","grant_number":"26137","_id":"6285a163-2b32-11ec-9570-8e204ca2dba5"},{"call_identifier":"H2020","name":"International IST Doctoral Program","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"},{"grant_number":"101044865","name":"Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders","_id":"34ba8964-11ca-11ed-8bc3-e15864e7e9a6"},{"_id":"26AA4EF2-B435-11E9-9278-68D0E5697425","grant_number":"W1232-B24","name":"Molecular Drug Targets","call_identifier":"FWF"}],"page":"398-410","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","department":[{"_id":"JoDa"},{"_id":"GradSch"},{"_id":"Bio"},{"_id":"GaNo"}],"title":"Light-microscopy-based connectomic reconstruction of mammalian brain tissue","article_type":"original","oa_version":"Published Version","PlanS_conform":"1","type":"journal_article","file":[{"file_id":"19959","creator":"dernst","file_size":133201290,"relation":"main_file","access_level":"open_access","date_updated":"2025-07-03T06:55:20Z","file_name":"2025_Nature_Tavakoli.pdf","checksum":"ebc99d7108e728f46db0a009292675ef","success":1,"content_type":"application/pdf","date_created":"2025-07-03T06:55:20Z"}],"_id":"19704","ddc":["570"],"language":[{"iso":"eng"}],"OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","date_updated":"2026-04-28T13:33:34Z","publication_status":"published","status":"public","doi":"10.1038/s41586-025-08985-1","scopus_import":"1","intvolume":"       642"},{"volume":8,"article_number":"1572","day":"01","year":"2025","date_created":"2025-11-23T23:01:38Z","oa":1,"quality_controlled":"1","author":[{"last_name":"Serin","first_name":"Emin","full_name":"Serin, Emin"},{"first_name":"Kerstin","last_name":"Ritter","full_name":"Ritter, Kerstin"},{"full_name":"Schumann, Gunter","first_name":"Gunter","last_name":"Schumann"},{"last_name":"Banaschewski","first_name":"Tobias","full_name":"Banaschewski, Tobias"},{"first_name":"Andre","last_name":"Marquand","full_name":"Marquand, Andre"},{"full_name":"Walter, Henrik","last_name":"Walter","first_name":"Henrik"},{"last_name":"Ogoh","first_name":"George","full_name":"Ogoh, George"},{"full_name":"Stahl, Bernd Carsten","last_name":"Stahl","first_name":"Bernd Carsten"},{"first_name":"Ragnhild","last_name":"Brandlistuen","full_name":"Brandlistuen, Ragnhild"},{"full_name":"Schikowski, Tamara","first_name":"Tamara","last_name":"Schikowski"},{"last_name":"Young","first_name":"Allan H.","full_name":"Young, Allan H."},{"first_name":"Yu","last_name":"Xinyang","full_name":"Xinyang, Yu"},{"last_name":"Zhang","first_name":"Zuo","full_name":"Zhang, Zuo"},{"last_name":"Agunbiade","first_name":"Kofoworola","full_name":"Agunbiade, Kofoworola"},{"full_name":"Chen, Di","last_name":"Chen","first_name":"Di"},{"full_name":"Desrivières, Sylvane","first_name":"Sylvane","last_name":"Desrivières"},{"first_name":"Nicholas","last_name":"Clinton","full_name":"Clinton, Nicholas"},{"full_name":"Thompson, Paul","last_name":"Thompson","first_name":"Paul"},{"last_name":"Köhler","first_name":"Venessa","full_name":"Köhler, Venessa"},{"full_name":"Schwalber, Ameli","last_name":"Schwalber","first_name":"Ameli"},{"first_name":"Vince D.","last_name":"Calhoun","full_name":"Calhoun, Vince D."},{"first_name":"Xiao","last_name":"Chang","full_name":"Chang, Xiao"},{"first_name":"Yanqing","last_name":"Zhang","full_name":"Zhang, Yanqing"},{"full_name":"Li, Yuzhu","last_name":"Li","first_name":"Yuzhu"},{"full_name":"Dai, Yuxiang","last_name":"Dai","first_name":"Yuxiang"},{"first_name":"Jiacan","last_name":"Yuan","full_name":"Yuan, Jiacan"},{"full_name":"Xia, Yunman","last_name":"Xia","first_name":"Yunman"},{"full_name":"Jia, Tianye","last_name":"Jia","first_name":"Tianye"},{"full_name":"Renner, Paul","first_name":"Paul","last_name":"Renner"},{"full_name":"Hese, Sören","last_name":"Hese","first_name":"Sören"},{"full_name":"Spanlang, Bernhard","first_name":"Bernhard","last_name":"Spanlang"},{"first_name":"Charlie","last_name":"Pearmund","full_name":"Pearmund, Charlie"},{"last_name":"Athanasiadis","first_name":"Anastasios Polykarpos","full_name":"Athanasiadis, Anastasios Polykarpos"},{"full_name":"Petkoski, Spase","first_name":"Spase","last_name":"Petkoski"},{"first_name":"Viktor","last_name":"Jirsa","full_name":"Jirsa, Viktor"},{"last_name":"Schmitt","first_name":"Karen","full_name":"Schmitt, Karen"},{"first_name":"Johannes H.","last_name":"Wilbertz","full_name":"Wilbertz, Johannes H."},{"last_name":"Patraskaki","first_name":"Myrto","full_name":"Patraskaki, Myrto"},{"full_name":"Sommer, Peter","last_name":"Sommer","first_name":"Peter"},{"full_name":"Heilmann-Heimbach, Stefanie","first_name":"Stefanie","last_name":"Heilmann-Heimbach"},{"full_name":"Mathey, Carina M.","first_name":"Carina M.","last_name":"Mathey"},{"full_name":"Miller, Abigail J.","last_name":"Miller","first_name":"Abigail J."},{"full_name":"Claus, Isabelle","first_name":"Isabelle","last_name":"Claus"},{"full_name":"Nöthen, Markus M.","last_name":"Nöthen","first_name":"Markus M."},{"first_name":"Per","last_name":"Hoffmann","full_name":"Hoffmann, Per"},{"last_name":"Forstner","first_name":"Andreas J.","full_name":"Forstner, Andreas J."},{"last_name":"Pastor","first_name":"Alvaro","full_name":"Pastor, Alvaro"},{"first_name":"Jaime","last_name":"Gallego","full_name":"Gallego, Jaime"},{"full_name":"Itatani, Reiya","last_name":"Itatani","first_name":"Reiya"},{"full_name":"Eiroa-Orosa, Francisco","last_name":"Eiroa-Orosa","first_name":"Francisco"},{"full_name":"Feixas, Guillem","first_name":"Guillem","last_name":"Feixas"},{"full_name":"Slater, Mel","last_name":"Slater","first_name":"Mel"},{"orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","first_name":"Gaia","full_name":"Novarino, Gaia"},{"last_name":"Böttger","first_name":"Sarah Jane","full_name":"Böttger, Sarah Jane"},{"full_name":"Tschorn, Mira","first_name":"Mira","last_name":"Tschorn"},{"last_name":"Rapp","first_name":"Michael","full_name":"Rapp, Michael"},{"last_name":"Ask","first_name":"Helga","full_name":"Ask, Helga"},{"last_name":"Kjelkenes","first_name":"Rikka","full_name":"Kjelkenes, Rikka"},{"first_name":"Sara","last_name":"Fernandez","full_name":"Fernandez, Sara"},{"first_name":"Dennis","last_name":"Van Der Meer","full_name":"Van Der Meer, Dennis"},{"last_name":"Westlye","first_name":"Lars T.","full_name":"Westlye, Lars T."},{"full_name":"Andreassen, Ole A.","last_name":"Andreassen","first_name":"Ole A."},{"first_name":"Rieke","last_name":"Aden","full_name":"Aden, Rieke"},{"last_name":"Seefried","first_name":"Beke","full_name":"Seefried, Beke"},{"full_name":"Nees, Frauke","first_name":"Frauke","last_name":"Nees"},{"full_name":"Neidhart, Maja","first_name":"Maja","last_name":"Neidhart"},{"last_name":"Stringaris","first_name":"Argyris","full_name":"Stringaris, Argyris"},{"full_name":"Schwarz, Emanuel","last_name":"Schwarz","first_name":"Emanuel"},{"full_name":"Holz, Nathalie","last_name":"Holz","first_name":"Nathalie"},{"first_name":"Heike","last_name":"Tost","full_name":"Tost, Heike"},{"full_name":"Meyer-Lindenberg, Andreas","last_name":"Meyer-Lindenberg","first_name":"Andreas"},{"full_name":"Christmann, Nina","last_name":"Christmann","first_name":"Nina"},{"full_name":"Janson, Karina","last_name":"Janson","first_name":"Karina"},{"full_name":"Schepanski, Kerstin","first_name":"Kerstin","last_name":"Schepanski"},{"first_name":"Tatjana","last_name":"Schütz","full_name":"Schütz, Tatjana"},{"first_name":"Ulrike Helene","last_name":"Taron","full_name":"Taron, Ulrike Helene"},{"full_name":"Eils, Roland","first_name":"Roland","last_name":"Eils"},{"full_name":"Roy, Jean Charles","last_name":"Roy","first_name":"Jean Charles"},{"full_name":"Lett, Tristram A.","first_name":"Tristram A.","last_name":"Lett"},{"last_name":"Kebir","first_name":"Hedi","full_name":"Kebir, Hedi"},{"last_name":"Polemiti","first_name":"Elli","full_name":"Polemiti, Elli"},{"last_name":"Hitchen","first_name":"Esther","full_name":"Hitchen, Esther"},{"last_name":"Jentsch","first_name":"Marcel","full_name":"Jentsch, Marcel"},{"last_name":"Serin","first_name":"Emin","full_name":"Serin, Emin"},{"full_name":"Bernas, Antoine","first_name":"Antoine","last_name":"Bernas"},{"last_name":"Vaidya","first_name":"Nilakshi","full_name":"Vaidya, Nilakshi"},{"full_name":"Twardziok, Sven","last_name":"Twardziok","first_name":"Sven"},{"first_name":"Markus","last_name":"Ralser","full_name":"Ralser, Markus"},{"first_name":"Andreas","last_name":"Heinz","full_name":"Heinz, Andreas"},{"full_name":"Schumann, Gunter","first_name":"Gunter","last_name":"Schumann"}],"month":"12","abstract":[{"text":"Task-based functional magnetic resonance imaging (fMRI) reveals individual differences in neural correlates of cognition but faces scalability challenges due to cognitive demands, protocol variability, and limited task coverage in large datasets. Here, we propose DeepTaskGen, a deep-learning approach that synthesizes non-acquired task-based contrast maps from resting-state (rs-) fMRI. We validate this approach using the Human Connectome Project lifespan data, then generate 47 contrast maps from 7 different cognitive tasks for over 20,000 individuals from UK Biobank. DeepTaskGen outperforms several benchmarks in generating synthetic task-contrast maps, achieving superior reconstruction performance while retaining inter-individual variation essential for biomarker development. We further show comparable or superior predictive performance of synthetic maps relative to actual maps and rs-connectomes across diverse demographic, cognitive, and clinical variables. This approach facilitates the study of individual differences and the generation of task-related biomarkers by enabling the generation of arbitrary functional cognitive tasks from readily available rs-fMRI data.","lang":"eng"}],"citation":{"mla":"Serin, Emin, et al. “Generating Synthetic Task-Based Brain Fingerprints for Population Neuroscience Using Deep Learning.” <i>Communications Biology</i>, vol. 8, 1572, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s42003-025-09158-6\">10.1038/s42003-025-09158-6</a>.","ama":"Serin E, Ritter K, Schumann G, et al. Generating synthetic task-based brain fingerprints for population neuroscience using deep learning. <i>Communications Biology</i>. 2025;8. doi:<a href=\"https://doi.org/10.1038/s42003-025-09158-6\">10.1038/s42003-025-09158-6</a>","ista":"Serin E, Ritter K, Schumann G, Banaschewski T, Marquand A, Walter H, Ogoh G, Stahl BC, Brandlistuen R, Schikowski T, Young AH, Xinyang Y, Zhang Z, Agunbiade K, Chen D, Desrivières S, Clinton N, Thompson P, Köhler V, Schwalber A, Calhoun VD, Chang X, Zhang Y, Li Y, Dai Y, Yuan J, Xia Y, Jia T, Renner P, Hese S, Spanlang B, Pearmund C, Athanasiadis AP, Petkoski S, Jirsa V, Schmitt K, Wilbertz JH, Patraskaki M, Sommer P, Heilmann-Heimbach S, Mathey CM, Miller AJ, Claus I, Nöthen MM, Hoffmann P, Forstner AJ, Pastor A, Gallego J, Itatani R, Eiroa-Orosa F, Feixas G, Slater M, Novarino G, Böttger SJ, Tschorn M, Rapp M, Ask H, Kjelkenes R, Fernandez S, Van Der Meer D, Westlye LT, Andreassen OA, Aden R, Seefried B, Nees F, Neidhart M, Stringaris A, Schwarz E, Holz N, Tost H, Meyer-Lindenberg A, Christmann N, Janson K, Schepanski K, Schütz T, Taron UH, Eils R, Roy JC, Lett TA, Kebir H, Polemiti E, Hitchen E, Jentsch M, Serin E, Bernas A, Vaidya N, Twardziok S, Ralser M, Heinz A, Schumann G. 2025. Generating synthetic task-based brain fingerprints for population neuroscience using deep learning. Communications Biology. 8, 1572.","ieee":"E. Serin <i>et al.</i>, “Generating synthetic task-based brain fingerprints for population neuroscience using deep learning,” <i>Communications Biology</i>, vol. 8. Springer Nature, 2025.","apa":"Serin, E., Ritter, K., Schumann, G., Banaschewski, T., Marquand, A., Walter, H., … Schumann, G. (2025). Generating synthetic task-based brain fingerprints for population neuroscience using deep learning. <i>Communications Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42003-025-09158-6\">https://doi.org/10.1038/s42003-025-09158-6</a>","short":"E. Serin, K. Ritter, G. Schumann, T. Banaschewski, A. Marquand, H. Walter, G. Ogoh, B.C. Stahl, R. Brandlistuen, T. Schikowski, A.H. Young, Y. Xinyang, Z. Zhang, K. Agunbiade, D. Chen, S. Desrivières, N. Clinton, P. Thompson, V. Köhler, A. Schwalber, V.D. Calhoun, X. Chang, Y. Zhang, Y. Li, Y. Dai, J. Yuan, Y. Xia, T. Jia, P. Renner, S. Hese, B. Spanlang, C. Pearmund, A.P. Athanasiadis, S. Petkoski, V. Jirsa, K. Schmitt, J.H. Wilbertz, M. Patraskaki, P. Sommer, S. Heilmann-Heimbach, C.M. Mathey, A.J. Miller, I. Claus, M.M. Nöthen, P. Hoffmann, A.J. Forstner, A. Pastor, J. Gallego, R. Itatani, F. Eiroa-Orosa, G. Feixas, M. Slater, G. Novarino, S.J. Böttger, M. Tschorn, M. Rapp, H. Ask, R. Kjelkenes, S. Fernandez, D. Van Der Meer, L.T. Westlye, O.A. Andreassen, R. Aden, B. Seefried, F. Nees, M. Neidhart, A. Stringaris, E. Schwarz, N. Holz, H. Tost, A. Meyer-Lindenberg, N. Christmann, K. Janson, K. Schepanski, T. Schütz, U.H. Taron, R. Eils, J.C. Roy, T.A. Lett, H. Kebir, E. Polemiti, E. Hitchen, M. Jentsch, E. Serin, A. Bernas, N. Vaidya, S. Twardziok, M. Ralser, A. Heinz, G. Schumann, Communications Biology 8 (2025).","chicago":"Serin, Emin, Kerstin Ritter, Gunter Schumann, Tobias Banaschewski, Andre Marquand, Henrik Walter, George Ogoh, et al. “Generating Synthetic Task-Based Brain Fingerprints for Population Neuroscience Using Deep Learning.” <i>Communications Biology</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s42003-025-09158-6\">https://doi.org/10.1038/s42003-025-09158-6</a>."},"publication":"Communications Biology","pmid":1,"acknowledgement":"Funded by the European Union (Grant agreement No 101057429). Complementary funding was received by UK Research and Innovation (UKRI) under the UK government’s Horizon Europe funding guarantee (10131373 and 10038599) and the National Key R&D Program of Ministry of Science and Technology of China (MOST 2023YFE0199700). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union, the European Health and Digital Executive Agency (HADEA), UKRI or MOST. Neither the European Union nor HADEA nor UKRI nor MOST can be held responsible for them. This work has also been supported by a Grant from the German Research Foundation to the ENIGMA task-based fMRI Working Group (DFG ER 724/4–1, WA 1539/11–1). Data used in this study were provided in part by the Human Connectome Project, WU-Minn Consortium (principal investigators: D. Van Essen and K. Ugurbil; grant number 1U54MH091657), funded by the 16 National Institutes of Health (NIH) institutes and centers supporting the NIH Blueprint for Neuroscience Research, and by the McDonnell Center for Systems Neuroscience at Washington University. Additionally, this research utilized data obtained from UK Biobank, a large-scale biomedical database. Open Access funding enabled and organized by Projekt DEAL.","file_date_updated":"2025-11-24T09:12:19Z","external_id":{"isi":["001614464000001"],"pmid":["41238730"]},"date_published":"2025-12-01T00:00:00Z","OA_place":"publisher","publication_identifier":{"eissn":["2399-3642"]},"isi":1,"publisher":"Springer Nature","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"has_accepted_license":"1","department":[{"_id":"GaNo"}],"title":"Generating synthetic task-based brain fingerprints for population neuroscience using deep learning","article_type":"original","type":"journal_article","oa_version":"Published Version","PlanS_conform":"1","DOAJ_listed":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-12-01T15:24:07Z","status":"public","publication_status":"published","doi":"10.1038/s42003-025-09158-6","scopus_import":"1","intvolume":"         8","ddc":["570"],"file":[{"relation":"main_file","file_size":1588155,"creator":"dernst","file_id":"20675","date_created":"2025-11-24T09:12:19Z","content_type":"application/pdf","success":1,"checksum":"b8b3c1abe7048a09b920082a37e786a5","file_name":"2025_CommunicationsBiology_Serin.pdf","date_updated":"2025-11-24T09:12:19Z","access_level":"open_access"}],"_id":"20662","language":[{"iso":"eng"}],"article_processing_charge":"Yes (via OA deal)","OA_type":"gold"},{"publication":"Annual Review of Genetics","abstract":[{"text":"The adult human brain, under resting conditions, consumes approximately 20% of total body glucose, a demand that is even higher during the first decade of life. The brain metabolic landscape is intricately regulated throughout development, and each cell type exhibits distinct metabolic signatures at each specific stage. This picture becomes even more intricate when considering that metabolism is dynamically modulated to sustain critical biological processes, such as cell proliferation and differentiation and synaptic activity–dependent processes. The orchestration between metabolic regulation and the aforementioned physiological processes often relies on metabolism-dependent changes in the epigenetic landscape, which shape gene expression patterns to trigger selected downstream biological responses. Perturbations of brain metabolic pathways are frequently the cause of severe neurodevelopmental disorders. This review explores the latest insights into the regulation of brain metabolism in health and disease.","lang":"eng"}],"corr_author":"1","citation":{"ista":"Marano D, Mariano V, Novarino G. 2025. Fueling the mind: Brain metabolism in health and neurodevelopmental disorders. Annual Review of Genetics. 59, 415–434.","mla":"Marano, Domenico, et al. “Fueling the Mind: Brain Metabolism in Health and Neurodevelopmental Disorders.” <i>Annual Review of Genetics</i>, vol. 59, Annual Reviews, 2025, pp. 415–34, doi:<a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">10.1146/annurev-genet-111523-102424</a>.","ama":"Marano D, Mariano V, Novarino G. Fueling the mind: Brain metabolism in health and neurodevelopmental disorders. <i>Annual Review of Genetics</i>. 2025;59:415-434. doi:<a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">10.1146/annurev-genet-111523-102424</a>","apa":"Marano, D., Mariano, V., &#38; Novarino, G. (2025). Fueling the mind: Brain metabolism in health and neurodevelopmental disorders. <i>Annual Review of Genetics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">https://doi.org/10.1146/annurev-genet-111523-102424</a>","short":"D. Marano, V. Mariano, G. Novarino, Annual Review of Genetics 59 (2025) 415–434.","chicago":"Marano, Domenico, Vittoria Mariano, and Gaia Novarino. “Fueling the Mind: Brain Metabolism in Health and Neurodevelopmental Disorders.” <i>Annual Review of Genetics</i>. Annual Reviews, 2025. <a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">https://doi.org/10.1146/annurev-genet-111523-102424</a>.","ieee":"D. Marano, V. Mariano, and G. Novarino, “Fueling the mind: Brain metabolism in health and neurodevelopmental disorders,” <i>Annual Review of Genetics</i>, vol. 59. Annual Reviews, pp. 415–434, 2025."},"publisher":"Annual Reviews","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"has_accepted_license":"1","pmid":1,"external_id":{"pmid":["40902207"]},"date_published":"2025-11-03T00:00:00Z","acknowledgement":"Funding provided by the European Union (grant 101057429) to G.N.","file_date_updated":"2025-12-09T12:53:09Z","OA_place":"publisher","publication_identifier":{"eissn":["1545-2948"],"issn":["0066-4197"]},"day":"03","year":"2025","date_created":"2025-12-07T23:02:01Z","volume":59,"quality_controlled":"1","author":[{"full_name":"Marano, Domenico","last_name":"Marano","first_name":"Domenico","id":"3b004c42-803f-11ed-ab7e-ecee8f08bd58"},{"full_name":"Mariano, Vittoria","id":"ee829c33-edb3-11ed-b4fb-c020aaca4b01","first_name":"Vittoria","last_name":"Mariano"},{"full_name":"Novarino, Gaia","last_name":"Novarino","first_name":"Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"}],"month":"11","oa":1,"scopus_import":"1","doi":"10.1146/annurev-genet-111523-102424","intvolume":"        59","date_updated":"2025-12-09T12:55:11Z","status":"public","publication_status":"published","ddc":["570"],"_id":"20731","file":[{"file_size":3629986,"relation":"main_file","creator":"dernst","file_id":"20745","success":1,"date_created":"2025-12-09T12:53:09Z","content_type":"application/pdf","date_updated":"2025-12-09T12:53:09Z","access_level":"open_access","checksum":"1000228dc9aca3d48e92605607a99c41","file_name":"2025_AnnualRevGenetics_Marano.pdf"}],"article_processing_charge":"Yes (in subscription journal)","language":[{"iso":"eng"}],"OA_type":"hybrid","article_type":"review","type":"journal_article","PlanS_conform":"1","oa_version":"Published Version","department":[{"_id":"GaNo"}],"title":"Fueling the mind: Brain metabolism in health and neurodevelopmental disorders","page":"415-434","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"_id":"349d1832-11ca-11ed-8bc3-d79b574010e0","name":"Reducing the impact of major environmental challenges on mental health","grant_number":"101057429"}]},{"OA_type":"hybrid","language":[{"iso":"eng"}],"article_processing_charge":"Yes (in subscription journal)","ddc":["570"],"file":[{"creator":"dernst","file_id":"18784","relation":"main_file","file_size":26065165,"checksum":"57d5fafb16f02dcb9f7dddb1bd7e2a71","file_name":"2024_NatureBiotech_Michalska.pdf","date_updated":"2025-01-09T07:48:01Z","access_level":"open_access","date_created":"2025-01-09T07:48:01Z","content_type":"application/pdf","success":1}],"_id":"14257","status":"public","publication_status":"published","date_updated":"2026-04-14T08:34:35Z","intvolume":"        42","doi":"10.1038/s41587-023-01911-8","scopus_import":"1","project":[{"grant_number":"I03600","name":"Optical control of synaptic function via adhesion molecules","call_identifier":"FWF","_id":"265CB4D0-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","grant_number":"W1232","name":"Molecular Drug Targets","_id":"2548AE96-B435-11E9-9278-68D0E5697425"},{"name":"Synaptic communication in neuronal microcircuits","grant_number":"Z00312","call_identifier":"FWF","_id":"25C5A090-B435-11E9-9278-68D0E5697425"},{"grant_number":"LS18-022","name":"High content imaging to decode human immune cell interactions in health and allergic disease","_id":"23889792-32DE-11EA-91FC-C7463DDC885E"},{"_id":"25444568-B435-11E9-9278-68D0E5697425","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","grant_number":"715508","call_identifier":"H2020"},{"call_identifier":"H2020","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","grant_number":"692692","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425"},{"name":"International IST Doctoral Program","grant_number":"665385","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","name":"Synaptic computations of the hippocampal CA3 circuitry","grant_number":"101026635","_id":"fc2be41b-9c52-11eb-aca3-faa90aa144e9"}],"ec_funded":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"1051-1064","title":"Imaging brain tissue architecture across millimeter to nanometer scales","department":[{"_id":"SaSi"},{"_id":"GaNo"},{"_id":"PeJo"},{"_id":"JoDa"},{"_id":"Bio"},{"_id":"RySh"}],"type":"journal_article","oa_version":"Published Version","article_type":"original","file_date_updated":"2025-01-09T07:48:01Z","acknowledgement":"We thank J. Vorlaufer, N. Agudelo-Dueñas, W. Jahr and A. Wartak for microscope maintenance and troubleshooting; C. Kreuzinger, A. Freeman and I. Erber for technical assistance; and M. Tomschik for support with obtaining human samples. We gratefully acknowledge E. Miguel for setting up webKnossos and M. Šuplata for computational support and hardware control. We are grateful to R. Shigemoto and B. Bickel for generous support and M. Sixt and S. Boyd (Stanford University) for discussions and critical reading of the paper. PSD95-HaloTag mice were kindly provided by S. Grant (University of Edinburgh). We acknowledge expert support by Institute of Science and Technology Austria’s scientific computing, imaging and optics, preclinical and lab support facilities and by the Miba machine shop and library. We gratefully acknowledge funding by the following sources: Austrian Science Fund (FWF) grant I3600-B27 (J.G.D.); Austrian Science Fund (FWF) grant DK W1232 (J.G.D. and J.M.M.); Austrian Science Fund (FWF) grant Z 312-B27, Wittgenstein award (P.J.); Austrian Science Fund (FWF) projects I4685-B, I6565-B (SYNABS) and DOC 33-B27 (R.H.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 715508 – REVERSEAUTISM (G.N.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 692692 – GIANTSYN (P.J.); Marie Skłodowska-Curie Actions Fellowship GA no. 665385 under the EU Horizon 2020 program (J.M.M. and J.L.); and Marie Skłodowska-Curie Actions Individual Fellowship no. 101026635 under the EU Horizon 2020 program (J.F.W.).","date_published":"2024-07-01T00:00:00Z","external_id":{"isi":["001065254200001"],"pmid":["37653226"]},"OA_place":"publisher","publication_identifier":{"issn":["1087-0156"],"eissn":["1546-1696"]},"pmid":1,"has_accepted_license":"1","isi":1,"publisher":"Springer Nature","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"citation":{"ama":"Michalska JM, Lyudchik J, Velicky P, et al. Imaging brain tissue architecture across millimeter to nanometer scales. <i>Nature Biotechnology</i>. 2024;42:1051-1064. doi:<a href=\"https://doi.org/10.1038/s41587-023-01911-8\">10.1038/s41587-023-01911-8</a>","mla":"Michalska, Julia M., et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” <i>Nature Biotechnology</i>, vol. 42, Springer Nature, 2024, pp. 1051–64, doi:<a href=\"https://doi.org/10.1038/s41587-023-01911-8\">10.1038/s41587-023-01911-8</a>.","ista":"Michalska JM, Lyudchik J, Velicky P, Korinkova H, Watson J, Cenameri A, Sommer CM, Amberg N, Venturino A, Roessler K, Czech T, Höftberger R, Siegert S, Novarino G, Jonas PM, Danzl JG. 2024. Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. 42, 1051–1064.","ieee":"J. M. Michalska <i>et al.</i>, “Imaging brain tissue architecture across millimeter to nanometer scales,” <i>Nature Biotechnology</i>, vol. 42. Springer Nature, pp. 1051–1064, 2024.","short":"J.M. Michalska, J. Lyudchik, P. Velicky, H. Korinkova, J. Watson, A. Cenameri, C.M. Sommer, N. Amberg, A. Venturino, K. Roessler, T. Czech, R. Höftberger, S. Siegert, G. Novarino, P.M. Jonas, J.G. Danzl, Nature Biotechnology 42 (2024) 1051–1064.","chicago":"Michalska, Julia M, Julia Lyudchik, Philipp Velicky, Hana Korinkova, Jake Watson, Alban Cenameri, Christoph M Sommer, et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” <i>Nature Biotechnology</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41587-023-01911-8\">https://doi.org/10.1038/s41587-023-01911-8</a>.","apa":"Michalska, J. M., Lyudchik, J., Velicky, P., Korinkova, H., Watson, J., Cenameri, A., … Danzl, J. G. (2024). Imaging brain tissue architecture across millimeter to nanometer scales. <i>Nature Biotechnology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41587-023-01911-8\">https://doi.org/10.1038/s41587-023-01911-8</a>"},"abstract":[{"text":"Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but fails to provide tissue context. Here we developed Comprehensive Analysis of Tissues across Scales (CATS), a technology to densely map brain tissue architecture from millimeter regional to nanometer synaptic scales in diverse chemically fixed brain preparations, including rodent and human. CATS uses fixation-compatible extracellular labeling and optical imaging, including stimulated emission depletion or expansion microscopy, to comprehensively delineate cellular structures. It enables three-dimensional reconstruction of single synapses and mapping of synaptic connectivity by identification and analysis of putative synaptic cleft regions. Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input and output structure of identified neurons. We furthermore demonstrate applicability to clinically derived human tissue samples, including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing the cellular architecture of brain tissue in health and disease.","lang":"eng"}],"corr_author":"1","publication":"Nature Biotechnology","oa":1,"month":"07","quality_controlled":"1","related_material":{"link":[{"relation":"software","url":"https://github.com/danzllab/CATS"}],"record":[{"status":"deleted","id":"18660","relation":"dissertation_contains"},{"relation":"research_data","id":"13126","status":"public"},{"id":"18674","status":"public","relation":"dissertation_contains"}]},"author":[{"full_name":"Michalska, Julia M","first_name":"Julia M","last_name":"Michalska","orcid":"0000-0003-3862-1235","id":"443DB6DE-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Lyudchik, Julia","id":"46E28B80-F248-11E8-B48F-1D18A9856A87","last_name":"Lyudchik","first_name":"Julia"},{"full_name":"Velicky, Philipp","last_name":"Velicky","first_name":"Philipp","orcid":"0000-0002-2340-7431","id":"39BDC62C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Korinkova","first_name":"Hana","id":"ee3cb6ca-ec98-11ea-ae11-ff703e2254ed","full_name":"Korinkova, Hana"},{"full_name":"Watson, Jake","last_name":"Watson","first_name":"Jake","id":"63836096-4690-11EA-BD4E-32803DDC885E","orcid":"0000-0002-8698-3823"},{"full_name":"Cenameri, Alban","id":"9ac8f577-2357-11eb-997a-e566c5550886","first_name":"Alban","last_name":"Cenameri"},{"last_name":"Sommer","first_name":"Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1216-9105","full_name":"Sommer, Christoph M"},{"full_name":"Amberg, Nicole","last_name":"Amberg","first_name":"Nicole","orcid":"0000-0002-3183-8207","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Venturino, Alessandro","last_name":"Venturino","first_name":"Alessandro","orcid":"0000-0003-2356-9403","id":"41CB84B2-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Roessler","first_name":"Karl","full_name":"Roessler, Karl"},{"last_name":"Czech","first_name":"Thomas","full_name":"Czech, Thomas"},{"first_name":"Romana","last_name":"Höftberger","full_name":"Höftberger, Romana"},{"last_name":"Siegert","first_name":"Sandra","orcid":"0000-0001-8635-0877","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","full_name":"Siegert, Sandra"},{"orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","first_name":"Gaia","full_name":"Novarino, Gaia"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","last_name":"Jonas","first_name":"Peter M","full_name":"Jonas, Peter M"},{"first_name":"Johann G","last_name":"Danzl","orcid":"0000-0001-8559-3973","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","full_name":"Danzl, Johann G"}],"volume":42,"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"},{"_id":"PreCl"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"E-Lib"}],"date_created":"2023-09-03T22:01:15Z","day":"01","year":"2024"},{"citation":{"ieee":"L. Burnett <i>et al.</i>, “Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice.” Institute of Science and Technology Austria, 2024.","apa":"Burnett, L., Koppensteiner, P., Symonova, O., Masson, T., Vega Zuniga, T. A., Contreras, X., … Jösch, M. A. (2024). Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:15385\">https://doi.org/10.15479/AT:ISTA:15385</a>","short":"L. Burnett, P. Koppensteiner, O. Symonova, T. Masson, T.A. Vega Zuniga, X. Contreras, T. Rülicke, R. Shigemoto, G. Novarino, M.A. Jösch, (2024).","chicago":"Burnett, Laura, Peter Koppensteiner, Olga Symonova, Tomas Masson, Tomas A Vega Zuniga, Ximena Contreras, Thomas Rülicke, Ryuichi Shigemoto, Gaia Novarino, and Maximilian A Jösch. “Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:15385\">https://doi.org/10.15479/AT:ISTA:15385</a>.","mla":"Burnett, Laura, et al. <i>Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:15385\">10.15479/AT:ISTA:15385</a>.","ama":"Burnett L, Koppensteiner P, Symonova O, et al. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:15385\">10.15479/AT:ISTA:15385</a>","ista":"Burnett L, Koppensteiner P, Symonova O, Masson T, Vega Zuniga TA, Contreras X, Rülicke T, Shigemoto R, Novarino G, Jösch MA. 2024. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:15385\">10.15479/AT:ISTA:15385</a>."},"status":"public","abstract":[{"text":"Relevant information about the data can be found in the 'Readme_Data.txt' file. \r\nA previous version of the publication can be found on BioRxiv: https://www.biorxiv.org/content/10.1101/2022.10.11.511691v4\r\nand published in Plos Biology (2024)","lang":"eng"}],"corr_author":"1","date_updated":"2025-09-08T07:57:11Z","doi":"10.15479/AT:ISTA:15385","date_published":"2024-05-15T00:00:00Z","acknowledgement":"We thank Armel Nicolas, Bella Bruszel and Ewelina Dutkiewicz from the ISTA Mass Spectrometry Service (Lab Services Facilities) for all Proteomics work, including samples preparation, LC/MS data acquisition, searches and data evaluation. We thank Prof. Peter Jonas for his suggestion on the involvement of potassium channels and members of the Neuroethology group for their comments on the manuscript. Katalin Szigeti and Julie Murmann for experimental help. This research was supported by the Scientific Service Units of ISTA through resources provided by the Lab Support Facility, the Imaging and Optics Facility, the Machine Shop Unit and the Preclinical Facility, especially Freyja Langer and Michael Schunn. ","file_date_updated":"2024-05-16T09:08:20Z","article_processing_charge":"No","has_accepted_license":"1","ddc":["570"],"publisher":"Institute of Science and Technology Austria","tmp":{"image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"file":[{"file_id":"15396","creator":"mjoesch","relation":"main_file","file_size":"1149617663","checksum":"9205eb0876f0f08552dbad80d6884b4b","file_name":"PatchClamp.zip","date_updated":"2024-05-15T06:09:17Z","access_level":"open_access","date_created":"2024-05-15T06:09:17Z","content_type":"application/zip","success":1},{"date_created":"2024-05-15T06:09:12Z","content_type":"application/zip","success":1,"file_name":"SiliconProbe.zip","date_updated":"2024-05-15T06:09:12Z","access_level":"open_access","file_size":"564903112","relation":"main_file","creator":"mjoesch","file_id":"15397"},{"file_id":"15398","creator":"mjoesch","relation":"main_file","file_size":"11685703","date_updated":"2024-05-15T06:09:14Z","access_level":"open_access","checksum":"49a807bbab06b5fada38f532e2176e2e","file_name":"WesternBlot.zip","success":1,"date_created":"2024-05-15T06:09:14Z","content_type":"application/zip"},{"creator":"mjoesch","file_id":"15399","relation":"main_file","file_size":"1335626779","checksum":"beeeeaa43770090f3b291209ed6b0623","file_name":"Behaviour.zip","date_updated":"2024-05-15T06:09:38Z","access_level":"open_access","date_created":"2024-05-15T06:09:38Z","content_type":"application/zip","success":1},{"date_updated":"2024-05-16T09:08:20Z","access_level":"open_access","checksum":"8862ad7719388304d1d19f8e7db8bb00","file_name":"Readme_Data.txt","success":1,"date_created":"2024-05-16T09:08:20Z","content_type":"text/plain","creator":"mjoesch","file_id":"15400","relation":"main_file","file_size":18841}],"_id":"15385","title":"Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice","department":[{"_id":"MaJö"},{"_id":"PreCl"},{"_id":"SiHi"},{"_id":"RySh"},{"_id":"GaNo"}],"acknowledged_ssus":[{"_id":"PreCl"},{"_id":"M-Shop"},{"_id":"LifeSc"},{"_id":"Bio"}],"type":"research_data","date_created":"2024-05-13T15:04:04Z","oa_version":"Published Version","day":"15","keyword":["ASD","periaqueductal gray","perception","behavior","potassium channels"],"year":"2024","oa":1,"month":"05","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","author":[{"last_name":"Burnett","first_name":"Laura","id":"3B717F68-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8937-410X","full_name":"Burnett, Laura"},{"orcid":"0000-0002-3509-1948","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","first_name":"Peter","last_name":"Koppensteiner","full_name":"Koppensteiner, Peter"},{"full_name":"Symonova, Olga","orcid":"0000-0003-2012-9947","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87","last_name":"Symonova","first_name":"Olga"},{"full_name":"Masson, Tomas","id":"93ac43e8-8599-11eb-9b86-f6efb0a4c207","orcid":"0000-0002-2634-6283","first_name":"Tomas","last_name":"Masson"},{"full_name":"Vega Zuniga, Tomas A","first_name":"Tomas A","last_name":"Vega Zuniga","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Contreras, Ximena","id":"475990FE-F248-11E8-B48F-1D18A9856A87","first_name":"Ximena","last_name":"Contreras"},{"last_name":"Rülicke","first_name":"Thomas","full_name":"Rülicke, Thomas"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto"},{"full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","last_name":"Novarino","first_name":"Gaia"},{"first_name":"Maximilian A","last_name":"Jösch","orcid":"0000-0002-3937-1330","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","full_name":"Jösch, Maximilian A"}],"related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"17142"}]}},{"corr_author":"1","abstract":[{"lang":"eng","text":"DNA sequences are connected to genes and functions in the developing and adult brain"}],"citation":{"ieee":"G. Novarino and C. Bock, “Mapping the brain’s gene-regulatory maze,” <i>Science</i>, vol. 384, no. 6698. AAAS, pp. 860–861, 2024.","chicago":"Novarino, Gaia, and Christoph Bock. “Mapping the Brain’s Gene-Regulatory Maze.” <i>Science</i>. AAAS, 2024. <a href=\"https://doi.org/10.1126/science.adp4663\">https://doi.org/10.1126/science.adp4663</a>.","short":"G. Novarino, C. Bock, Science 384 (2024) 860–861.","apa":"Novarino, G., &#38; Bock, C. (2024). Mapping the brain’s gene-regulatory maze. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adp4663\">https://doi.org/10.1126/science.adp4663</a>","ama":"Novarino G, Bock C. Mapping the brain’s gene-regulatory maze. <i>Science</i>. 2024;384(6698):860-861. doi:<a href=\"https://doi.org/10.1126/science.adp4663\">10.1126/science.adp4663</a>","mla":"Novarino, Gaia, and Christoph Bock. “Mapping the Brain’s Gene-Regulatory Maze.” <i>Science</i>, vol. 384, no. 6698, AAAS, 2024, pp. 860–61, doi:<a href=\"https://doi.org/10.1126/science.adp4663\">10.1126/science.adp4663</a>.","ista":"Novarino G, Bock C. 2024. Mapping the brain’s gene-regulatory maze. Science. 384(6698), 860–861."},"publication":"Science","pmid":1,"publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"date_published":"2024-05-24T00:00:00Z","external_id":{"isi":["001230076500007"],"pmid":["38781359"]},"publisher":"AAAS","isi":1,"volume":384,"year":"2024","day":"24","date_created":"2024-06-02T22:00:57Z","author":[{"full_name":"Novarino, Gaia","first_name":"Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178"},{"last_name":"Bock","first_name":"Christoph","full_name":"Bock, Christoph"}],"quality_controlled":"1","month":"05","date_updated":"2025-09-08T07:40:10Z","publication_status":"published","issue":"6698","status":"public","doi":"10.1126/science.adp4663","scopus_import":"1","intvolume":"       384","_id":"17091","language":[{"iso":"eng"}],"article_processing_charge":"No","department":[{"_id":"GaNo"}],"title":"Mapping the brain’s gene-regulatory maze","article_type":"letter_note","oa_version":"None","type":"journal_article","page":"860-861","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345"},{"oa_version":"Published Version","type":"journal_article","article_type":"original","title":"Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice","department":[{"_id":"RySh"},{"_id":"GaNo"},{"_id":"MaJö"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","project":[{"_id":"2634E9D2-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Circuits of Visual Attention","grant_number":"756502"}],"DOAJ_listed":"1","ec_funded":1,"intvolume":"        22","scopus_import":"1","doi":"10.1371/journal.pbio.3002668","publication_status":"published","status":"public","date_updated":"2025-09-08T07:57:11Z","language":[{"iso":"eng"}],"article_processing_charge":"Yes","OA_type":"gold","_id":"17142","file":[{"checksum":"496e1aa4fd5b92b7e4087ecc2c964133","file_name":"2024_PloS_Burnett.pdf","date_updated":"2025-01-09T10:39:41Z","access_level":"open_access","date_created":"2025-01-09T10:39:41Z","content_type":"application/pdf","success":1,"creator":"dernst","file_id":"18805","relation":"main_file","file_size":4016568}],"ddc":["570"],"date_created":"2024-06-16T22:01:05Z","year":"2024","day":"10","article_number":"e3002668","volume":22,"month":"06","related_material":{"record":[{"id":"15385","status":"public","relation":"research_data"}],"link":[{"url":"https://doi.org/10.5281/zenodo.11130587","relation":"software"}]},"author":[{"full_name":"Burnett, Laura","first_name":"Laura","last_name":"Burnett","id":"3B717F68-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8937-410X"},{"full_name":"Koppensteiner, Peter","first_name":"Peter","last_name":"Koppensteiner","orcid":"0000-0002-3509-1948","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87"},{"id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2012-9947","last_name":"Symonova","first_name":"Olga","full_name":"Symonova, Olga"},{"full_name":"Masson, Tomas","last_name":"Masson","first_name":"Tomas","orcid":"0000-0002-2634-6283","id":"93ac43e8-8599-11eb-9b86-f6efb0a4c207"},{"full_name":"Vega Zuniga, Tomas A","first_name":"Tomas A","last_name":"Vega Zuniga","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Contreras, Ximena","last_name":"Contreras","first_name":"Ximena","id":"475990FE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Rülicke","first_name":"Thomas","full_name":"Rülicke, Thomas"},{"full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto"},{"first_name":"Gaia","last_name":"Novarino","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia"},{"first_name":"Maximilian A","last_name":"Jösch","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3937-1330","full_name":"Jösch, Maximilian A"}],"quality_controlled":"1","oa":1,"publication":"PLoS Biology","citation":{"mla":"Burnett, Laura, et al. “Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice.” <i>PLoS Biology</i>, vol. 22, e3002668, Public Library of Science, 2024, doi:<a href=\"https://doi.org/10.1371/journal.pbio.3002668\">10.1371/journal.pbio.3002668</a>.","ama":"Burnett L, Koppensteiner P, Symonova O, et al. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. <i>PLoS Biology</i>. 2024;22. doi:<a href=\"https://doi.org/10.1371/journal.pbio.3002668\">10.1371/journal.pbio.3002668</a>","ista":"Burnett L, Koppensteiner P, Symonova O, Masson T, Vega Zuniga TA, Contreras X, Rülicke T, Shigemoto R, Novarino G, Jösch MA. 2024. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. PLoS Biology. 22, e3002668.","ieee":"L. Burnett <i>et al.</i>, “Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice,” <i>PLoS Biology</i>, vol. 22. Public Library of Science, 2024.","apa":"Burnett, L., Koppensteiner, P., Symonova, O., Masson, T., Vega Zuniga, T. A., Contreras, X., … Jösch, M. A. (2024). Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. <i>PLoS Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pbio.3002668\">https://doi.org/10.1371/journal.pbio.3002668</a>","chicago":"Burnett, Laura, Peter Koppensteiner, Olga Symonova, Tomas Masson, Tomas A Vega Zuniga, Ximena Contreras, Thomas Rülicke, Ryuichi Shigemoto, Gaia Novarino, and Maximilian A Jösch. “Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice.” <i>PLoS Biology</i>. Public Library of Science, 2024. <a href=\"https://doi.org/10.1371/journal.pbio.3002668\">https://doi.org/10.1371/journal.pbio.3002668</a>.","short":"L. Burnett, P. Koppensteiner, O. Symonova, T. Masson, T.A. Vega Zuniga, X. Contreras, T. Rülicke, R. Shigemoto, G. Novarino, M.A. Jösch, PLoS Biology 22 (2024)."},"corr_author":"1","abstract":[{"lang":"eng","text":"Despite the diverse genetic origins of autism spectrum disorders (ASDs), affected individuals share strikingly similar and correlated behavioural traits that include perceptual and sensory processing challenges. Notably, the severity of these sensory symptoms is often predictive of the expression of other autistic traits. However, the origin of these perceptual deficits remains largely elusive. Here, we show a recurrent impairment in visual threat perception that is similarly impaired in 3 independent mouse models of ASD with different molecular aetiologies. Interestingly, this deficit is associated with reduced avoidance of threatening environments—a nonperceptual trait. Focusing on a common cause of ASDs, the Setd5 gene mutation, we define the molecular mechanism. We show that the perceptual impairment is caused by a potassium channel (Kv1)-mediated hypoexcitability in a subcortical node essential for the initiation of escape responses, the dorsal periaqueductal grey (dPAG). Targeted pharmacological Kv1 blockade rescued both perceptual and place avoidance deficits, causally linking seemingly unrelated trait deficits to the dPAG. Furthermore, we show that different molecular mechanisms converge on similar behavioural phenotypes by demonstrating that the autism models Cul3 and Ptchd1, despite having similar behavioural phenotypes, differ in their functional and molecular alteration. Our findings reveal a link between rapid perception controlled by subcortical pathways and appropriate learned interactions with the environment and define a nondevelopmental source of such deficits in ASD."}],"has_accepted_license":"1","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"APC_amount":"6081,83 EUR","isi":1,"publisher":"Public Library of Science","publication_identifier":{"issn":["1544-9173"],"eissn":["1545-7885"]},"OA_place":"publisher","date_published":"2024-06-10T00:00:00Z","external_id":{"isi":["001246176800003"],"pmid":["38857283"]},"acknowledgement":"This work was supported by a European Research Council Starting Grant 756502 (MJ). ","file_date_updated":"2025-01-09T10:39:41Z","pmid":1},{"publication_status":"draft","status":"public","date_updated":"2026-04-28T13:33:34Z","doi":"10.1101/2024.03.01.582884","language":[{"iso":"eng"}],"article_processing_charge":"No","_id":"18677","title":"Light-microscopy based dense connectomic reconstruction of mammalian brain tissue","department":[{"_id":"GaNo"},{"_id":"JoDa"}],"oa_version":"Preprint","type":"preprint","project":[{"grant_number":"26137","name":"Studying Organelle Structure and Function at Nanoscale Resolution with Expansion Microscopy","_id":"6285a163-2b32-11ec-9570-8e204ca2dba5"},{"name":"International IST Doctoral Program","grant_number":"665385","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"},{"_id":"34ba8964-11ca-11ed-8bc3-e15864e7e9a6","grant_number":"101044865","name":"Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders"},{"grant_number":"W1232-B24","name":"Molecular Drug Targets","call_identifier":"FWF","_id":"26AA4EF2-B435-11E9-9278-68D0E5697425"}],"ec_funded":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"Tavakoli, Mojtaba, et al. “Light-Microscopy Based Dense Connectomic Reconstruction of Mammalian Brain Tissue.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2024.03.01.582884\">10.1101/2024.03.01.582884</a>.","ama":"Tavakoli M, Lyudchik J, Januszewski M, et al. Light-microscopy based dense connectomic reconstruction of mammalian brain tissue. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2024.03.01.582884\">10.1101/2024.03.01.582884</a>","ista":"Tavakoli M, Lyudchik J, Januszewski M, Vistunou V, Agudelo Duenas N, Vorlaufer J, Sommer CM, Kreuzinger C, Oliveira B, Cenameri A, Novarino G, Jain V, Danzl JG. Light-microscopy based dense connectomic reconstruction of mammalian brain tissue. bioRxiv, <a href=\"https://doi.org/10.1101/2024.03.01.582884\">10.1101/2024.03.01.582884</a>.","ieee":"M. Tavakoli <i>et al.</i>, “Light-microscopy based dense connectomic reconstruction of mammalian brain tissue,” <i>bioRxiv</i>. .","apa":"Tavakoli, M., Lyudchik, J., Januszewski, M., Vistunou, V., Agudelo Duenas, N., Vorlaufer, J., … Danzl, J. G. (n.d.). Light-microscopy based dense connectomic reconstruction of mammalian brain tissue. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2024.03.01.582884\">https://doi.org/10.1101/2024.03.01.582884</a>","chicago":"Tavakoli, Mojtaba, Julia Lyudchik, Michał Januszewski, Vitali Vistunou, Nathalie Agudelo Duenas, Jakob Vorlaufer, Christoph M Sommer, et al. “Light-Microscopy Based Dense Connectomic Reconstruction of Mammalian Brain Tissue.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2024.03.01.582884\">https://doi.org/10.1101/2024.03.01.582884</a>.","short":"M. Tavakoli, J. Lyudchik, M. Januszewski, V. Vistunou, N. Agudelo Duenas, J. Vorlaufer, C.M. Sommer, C. Kreuzinger, B. Oliveira, A. Cenameri, G. Novarino, V. Jain, J.G. Danzl, BioRxiv (n.d.)."},"corr_author":"1","abstract":[{"text":"The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric imaging at nanoscale resolution with dense cellular labeling. Light microscopy is uniquely positioned to visualize specific molecules but dense, synapse-level circuit reconstruction by light microscopy has been out of reach due to limitations in resolution, contrast, and volumetric imaging capability. Here we developed light-microscopy based connectomics (LICONN). We integrated specifically engineered hydrogel embedding and expansion with comprehensive deep-learning based segmentation and analysis of connectivity, thus directly incorporating molecular information in synapse-level brain tissue reconstructions. LICONN will allow synapse-level brain tissue phenotyping in biological experiments in a readily adoptable manner.","lang":"eng"}],"publication":"bioRxiv","main_file_link":[{"url":"https://doi.org/10.1101/2024.03.01.582884","open_access":"1"}],"OA_place":"repository","acknowledgement":"We thank Sven Dorkenwald and Peter Li for critical reading of the\r\nmanuscript. We acknowledge expert support by ISTA’s scientific service units: Imaging and\r\nOptics, Lab Support, Scientific Computing, Preclinical Facility, Miba Machine Shop, and Library.\r\nWe gratefully acknowledge funding by the following sources:\r\nAustrian Science Fund (FWF) grant DK W1232 (JGD, MRT)\r\nAustrian Academy of Sciences DOC fellowship 26137 (MRT)\r\nEU Horizon 2020 program, Marie Skłodowska-Curie Actions Fellowship 665385 (JL)\r\nGesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (JGD)\r\nEuropean Union’s Horizon 2020 research and innovation programme, European Research\r\nCouncil (ERC) grant 101044865 “SecretAutism.”\r\n","date_published":"2024-07-08T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"date_created":"2024-12-18T14:48:24Z","acknowledged_ssus":[{"_id":"E-Lib"},{"_id":"M-Shop"},{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"ScienComp"}],"year":"2024","day":"08","oa":1,"month":"07","author":[{"first_name":"Mojtaba","last_name":"Tavakoli","orcid":"0000-0002-7667-6854","id":"3A0A06F4-F248-11E8-B48F-1D18A9856A87","full_name":"Tavakoli, Mojtaba"},{"full_name":"Lyudchik, Julia","first_name":"Julia","last_name":"Lyudchik","id":"46E28B80-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Januszewski, Michał","last_name":"Januszewski","first_name":"Michał"},{"full_name":"Vistunou, Vitali","last_name":"Vistunou","first_name":"Vitali","id":"7e146587-8972-11ed-ae7b-d7a32ea86a81"},{"id":"40E7F008-F248-11E8-B48F-1D18A9856A87","first_name":"Nathalie","last_name":"Agudelo Duenas","full_name":"Agudelo Duenas, Nathalie"},{"first_name":"Jakob","last_name":"Vorlaufer","orcid":"0009-0000-7590-3501","id":"937696FA-C996-11E9-8C7C-CF13E6697425","full_name":"Vorlaufer, Jakob"},{"full_name":"Sommer, Christoph M","first_name":"Christoph M","last_name":"Sommer","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1216-9105"},{"id":"382077BA-F248-11E8-B48F-1D18A9856A87","last_name":"Kreuzinger","first_name":"Caroline","full_name":"Kreuzinger, Caroline"},{"first_name":"Bárbara","last_name":"Oliveira","id":"3B03AA1A-F248-11E8-B48F-1D18A9856A87","full_name":"Oliveira, Bárbara"},{"last_name":"Cenameri","first_name":"Alban","id":"9ac8f577-2357-11eb-997a-e566c5550886","full_name":"Cenameri, Alban"},{"full_name":"Novarino, Gaia","last_name":"Novarino","first_name":"Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Viren","last_name":"Jain","full_name":"Jain, Viren"},{"last_name":"Danzl","first_name":"Johann G","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8559-3973","full_name":"Danzl, Johann G"}],"related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"18681"},{"relation":"dissertation_contains","id":"18674","status":"public"},{"id":"19704","status":"public","relation":"later_version"}]}},{"year":"2024","day":"01","date_created":"2025-03-23T23:01:28Z","volume":2,"author":[{"full_name":"Nees, Frauke","first_name":"Frauke","last_name":"Nees"},{"full_name":"Renner, Paul","last_name":"Renner","first_name":"Paul"},{"last_name":"Holz","first_name":"Nathalie E.","full_name":"Holz, Nathalie E."},{"full_name":"Polemiti, Elli","first_name":"Elli","last_name":"Polemiti"},{"first_name":"Sebastian","last_name":"Siehl","full_name":"Siehl, Sebastian"},{"full_name":"Hese, Sören","last_name":"Hese","first_name":"Sören"},{"last_name":"Schepanski","first_name":"Kerstin","full_name":"Schepanski, Kerstin"},{"first_name":"Gunter","last_name":"Schumann","full_name":"Schumann, Gunter"},{"first_name":"Henrik","last_name":"Walter","full_name":"Walter, Henrik"},{"last_name":"Heinz","first_name":"Andreas","full_name":"Heinz, Andreas"},{"last_name":"Ralser","first_name":"Markus","full_name":"Ralser, Markus"},{"first_name":"Sven","last_name":"Twardziok","full_name":"Twardziok, Sven"},{"full_name":"Vaidya, Nilakshi","last_name":"Vaidya","first_name":"Nilakshi"},{"first_name":"Antoine","last_name":"Bernas","full_name":"Bernas, Antoine"},{"first_name":"Emin","last_name":"Serin","full_name":"Serin, Emin"},{"first_name":"Marcel","last_name":"Jentsch","full_name":"Jentsch, Marcel"},{"full_name":"Hitchen, Esther","first_name":"Esther","last_name":"Hitchen"},{"last_name":"Kebir","first_name":"Hedi","full_name":"Kebir, Hedi"},{"first_name":"Tristram A.","last_name":"Lett","full_name":"Lett, Tristram A."},{"last_name":"Roy","first_name":"Jean Charles","full_name":"Roy, Jean Charles"},{"last_name":"Eils","first_name":"Roland","full_name":"Eils, Roland"},{"first_name":"Ulrike Helene","last_name":"Taron","full_name":"Taron, Ulrike Helene"},{"full_name":"Schütz, Tatjana","last_name":"Schütz","first_name":"Tatjana"},{"last_name":"Banks","first_name":"Jamie","full_name":"Banks, Jamie"},{"first_name":"Tobias","last_name":"Banaschewski","full_name":"Banaschewski, Tobias"},{"full_name":"Jansone, Karina","last_name":"Jansone","first_name":"Karina"},{"full_name":"Christmann, Nina","last_name":"Christmann","first_name":"Nina"},{"full_name":"Meyer-Lindenberg, Andreas","first_name":"Andreas","last_name":"Meyer-Lindenberg"},{"last_name":"Tost","first_name":"Heike","full_name":"Tost, Heike"},{"first_name":"Nathalie","last_name":"Holz","full_name":"Holz, Nathalie"},{"full_name":"Schwarz, Emanuel","first_name":"Emanuel","last_name":"Schwarz"},{"full_name":"Stringaris, Argyris","first_name":"Argyris","last_name":"Stringaris"},{"full_name":"Neidhart, Maja","last_name":"Neidhart","first_name":"Maja"},{"first_name":"Beke","last_name":"Seefried","full_name":"Seefried, Beke"},{"last_name":"Aden","first_name":"Rieke","full_name":"Aden, Rieke"},{"last_name":"Andreassen","first_name":"Ole A.","full_name":"Andreassen, Ole A."},{"full_name":"Westlye, Lars T.","first_name":"Lars T.","last_name":"Westlye"},{"full_name":"Van Der Meer, Dennis","last_name":"Van Der Meer","first_name":"Dennis"},{"first_name":"Sara","last_name":"Fernandez","full_name":"Fernandez, Sara"},{"full_name":"Kjelkenes, Rikka","last_name":"Kjelkenes","first_name":"Rikka"},{"full_name":"Ask, Helga","last_name":"Ask","first_name":"Helga"},{"full_name":"Rapp, Michael","first_name":"Michael","last_name":"Rapp"},{"full_name":"Tschorn, Mira","first_name":"Mira","last_name":"Tschorn"},{"full_name":"Böttger, Sarah Jane","last_name":"Böttger","first_name":"Sarah Jane"},{"full_name":"Marquand, Andre","last_name":"Marquand","first_name":"Andre"},{"full_name":"Novarino, Gaia","first_name":"Gaia","last_name":"Novarino","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Marr, Lena","id":"4406F586-F248-11E8-B48F-1D18A9856A87","first_name":"Lena","last_name":"Marr"},{"first_name":"Mel","last_name":"Slater","full_name":"Slater, Mel"},{"full_name":"Viapiana, Guillem Feixas","last_name":"Viapiana","first_name":"Guillem Feixas"},{"last_name":"Orosa","first_name":"Francisco Eiroa","full_name":"Orosa, Francisco Eiroa"},{"last_name":"Gallego","first_name":"Jaime","full_name":"Gallego, Jaime"},{"full_name":"Pastor, Alvaro","last_name":"Pastor","first_name":"Alvaro"},{"first_name":"Andreas J.","last_name":"Forstner","full_name":"Forstner, Andreas J."},{"last_name":"Hoffmann","first_name":"Per","full_name":"Hoffmann, Per"},{"full_name":"Nöthen, Markus M.","last_name":"Nöthen","first_name":"Markus M."},{"last_name":"Claus","first_name":"Isabelle","full_name":"Claus, Isabelle"},{"full_name":"Miller, Abigail","first_name":"Abigail","last_name":"Miller"},{"first_name":"Carina M.","last_name":"Mathey","full_name":"Mathey, Carina M."},{"last_name":"Heilmann-Heimbach","first_name":"Stefanie","full_name":"Heilmann-Heimbach, Stefanie"},{"first_name":"Peter","last_name":"Sommer","full_name":"Sommer, Peter"},{"full_name":"Patraskaki, Myrto","first_name":"Myrto","last_name":"Patraskaki"},{"first_name":"Johannes","last_name":"Wilbertz","full_name":"Wilbertz, Johannes"},{"first_name":"Karen","last_name":"Schmitt","full_name":"Schmitt, Karen"},{"first_name":"Viktor","last_name":"Jirsa","full_name":"Jirsa, Viktor"},{"first_name":"Spase","last_name":"Petkoski","full_name":"Petkoski, Spase"},{"full_name":"Pitel, Séverine","last_name":"Pitel","first_name":"Séverine"},{"full_name":"Otten, Lisa","first_name":"Lisa","last_name":"Otten"},{"full_name":"Athanasiadis, Anastasios Polykarpos","last_name":"Athanasiadis","first_name":"Anastasios Polykarpos"},{"full_name":"Pearmund, Charlie","first_name":"Charlie","last_name":"Pearmund"},{"first_name":"Bernhard","last_name":"Spanlang","full_name":"Spanlang, Bernhard"},{"first_name":"Elena","last_name":"Alvarez","full_name":"Alvarez, Elena"},{"full_name":"Sanchez, Mavi","last_name":"Sanchez","first_name":"Mavi"},{"full_name":"Giner, Arantxa","first_name":"Arantxa","last_name":"Giner"},{"last_name":"Jia","first_name":"Tianye","full_name":"Jia, Tianye"},{"first_name":"Yanting","last_name":"Gong","full_name":"Gong, Yanting"},{"first_name":"Yunman","last_name":"Xia","full_name":"Xia, Yunman"},{"first_name":"Xiao","last_name":"Chang","full_name":"Chang, Xiao"},{"first_name":"Vince","last_name":"Calhoun","full_name":"Calhoun, Vince"},{"full_name":"Liu, Jingyu","last_name":"Liu","first_name":"Jingyu"},{"first_name":"Ameli","last_name":"Schwalber","full_name":"Schwalber, Ameli"},{"first_name":"Paul","last_name":"Thompson","full_name":"Thompson, Paul"},{"full_name":"Clinton, Nicholas","last_name":"Clinton","first_name":"Nicholas"},{"first_name":"Sylvane","last_name":"Desrivières","full_name":"Desrivières, Sylvane"},{"full_name":"Young, Allan H.","last_name":"Young","first_name":"Allan H."},{"full_name":"Stahl, Bernd","first_name":"Bernd","last_name":"Stahl"},{"first_name":"George","last_name":"Ogoh","full_name":"Ogoh, George"}],"quality_controlled":"1","month":"10","publication":"Nature Mental Health","abstract":[{"lang":"eng","text":"This Comment explores new approaches to enrich large-scale population data, including incorporating macro-environmental and digital health measures."}],"citation":{"ieee":"F. Nees <i>et al.</i>, “Large-scale population data enrichment in mental health research,” <i>Nature Mental Health</i>, vol. 2, no. 10. Springer Nature, pp. 1124–1127, 2024.","apa":"Nees, F., Renner, P., Holz, N. E., Polemiti, E., Siehl, S., Hese, S., … Ogoh, G. (2024). Large-scale population data enrichment in mental health research. <i>Nature Mental Health</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s44220-024-00316-z\">https://doi.org/10.1038/s44220-024-00316-z</a>","chicago":"Nees, Frauke, Paul Renner, Nathalie E. Holz, Elli Polemiti, Sebastian Siehl, Sören Hese, Kerstin Schepanski, et al. “Large-Scale Population Data Enrichment in Mental Health Research.” <i>Nature Mental Health</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s44220-024-00316-z\">https://doi.org/10.1038/s44220-024-00316-z</a>.","short":"F. Nees, P. Renner, N.E. Holz, E. Polemiti, S. Siehl, S. Hese, K. Schepanski, G. Schumann, H. Walter, A. Heinz, M. Ralser, S. Twardziok, N. Vaidya, A. Bernas, E. Serin, M. Jentsch, E. Hitchen, H. Kebir, T.A. Lett, J.C. Roy, R. Eils, U.H. Taron, T. Schütz, J. Banks, T. Banaschewski, K. Jansone, N. Christmann, A. Meyer-Lindenberg, H. Tost, N. Holz, E. Schwarz, A. Stringaris, M. Neidhart, B. Seefried, R. Aden, O.A. Andreassen, L.T. Westlye, D. Van Der Meer, S. Fernandez, R. Kjelkenes, H. Ask, M. Rapp, M. Tschorn, S.J. Böttger, A. Marquand, G. Novarino, L. Marr, M. Slater, G.F. Viapiana, F.E. Orosa, J. Gallego, A. Pastor, A.J. Forstner, P. Hoffmann, M.M. Nöthen, I. Claus, A. Miller, C.M. Mathey, S. Heilmann-Heimbach, P. Sommer, M. Patraskaki, J. Wilbertz, K. Schmitt, V. Jirsa, S. Petkoski, S. Pitel, L. Otten, A.P. Athanasiadis, C. Pearmund, B. Spanlang, E. Alvarez, M. Sanchez, A. Giner, T. Jia, Y. Gong, Y. Xia, X. Chang, V. Calhoun, J. Liu, A. Schwalber, P. Thompson, N. Clinton, S. Desrivières, A.H. Young, B. Stahl, G. Ogoh, Nature Mental Health 2 (2024) 1124–1127.","mla":"Nees, Frauke, et al. “Large-Scale Population Data Enrichment in Mental Health Research.” <i>Nature Mental Health</i>, vol. 2, no. 10, Springer Nature, 2024, pp. 1124–27, doi:<a href=\"https://doi.org/10.1038/s44220-024-00316-z\">10.1038/s44220-024-00316-z</a>.","ama":"Nees F, Renner P, Holz NE, et al. Large-scale population data enrichment in mental health research. <i>Nature Mental Health</i>. 2024;2(10):1124-1127. doi:<a href=\"https://doi.org/10.1038/s44220-024-00316-z\">10.1038/s44220-024-00316-z</a>","ista":"Nees F, Renner P, Holz NE, Polemiti E, Siehl S, Hese S, Schepanski K, Schumann G, Walter H, Heinz A, Ralser M, Twardziok S, Vaidya N, Bernas A, Serin E, Jentsch M, Hitchen E, Kebir H, Lett TA, Roy JC, Eils R, Taron UH, Schütz T, Banks J, Banaschewski T, Jansone K, Christmann N, Meyer-Lindenberg A, Tost H, Holz N, Schwarz E, Stringaris A, Neidhart M, Seefried B, Aden R, Andreassen OA, Westlye LT, Van Der Meer D, Fernandez S, Kjelkenes R, Ask H, Rapp M, Tschorn M, Böttger SJ, Marquand A, Novarino G, Marr L, Slater M, Viapiana GF, Orosa FE, Gallego J, Pastor A, Forstner AJ, Hoffmann P, Nöthen MM, Claus I, Miller A, Mathey CM, Heilmann-Heimbach S, Sommer P, Patraskaki M, Wilbertz J, Schmitt K, Jirsa V, Petkoski S, Pitel S, Otten L, Athanasiadis AP, Pearmund C, Spanlang B, Alvarez E, Sanchez M, Giner A, Jia T, Gong Y, Xia Y, Chang X, Calhoun V, Liu J, Schwalber A, Thompson P, Clinton N, Desrivières S, Young AH, Stahl B, Ogoh G. 2024. Large-scale population data enrichment in mental health research. Nature Mental Health. 2(10), 1124–1127."},"publisher":"Springer Nature","publication_identifier":{"eissn":["2731-6076"]},"acknowledgement":"Funded by the European Union. Complementary funding was received by the UK Research and Innovation (UKRI) under the UK government’s Horizon Europe funding guarantee (10041392 and 10038599). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union, the European Health and Digital Executive Agency (HADEA) or UKRI. The European Union, HADEA and UKRI cannot be held responsible for them. This work received also support from Chinese Ministry for Science and Technology (MOST), the Horizon 2020-funded European Research Council Advanced Grant ‘STRATIFY’ (695313), the German Research Foundation (COPE; 675346; NE 1383/15-1 (CoviDrug)) and the National Natural Science Foundation of China grant 82150710554.","date_published":"2024-10-01T00:00:00Z","article_type":"letter_note","oa_version":"None","type":"journal_article","department":[{"_id":"GaNo"}],"title":"Large-scale population data enrichment in mental health research","page":"1124-1127","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1038/s44220-024-00316-z","scopus_import":"1","intvolume":"         2","date_updated":"2025-03-25T08:28:39Z","issue":"10","publication_status":"published","status":"public","_id":"19446","language":[{"iso":"eng"}],"article_processing_charge":"No","OA_type":"closed access"},{"type":"journal_article","oa_version":"None","article_type":"comment","title":"A protocol for data harmonization in large cohorts","department":[{"_id":"GaNo"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"1134-1137","intvolume":"         2","doi":"10.1038/s44220-024-00315-0","scopus_import":"1","status":"public","issue":"10","publication_status":"published","date_updated":"2025-07-22T08:59:10Z","language":[{"iso":"eng"}],"OA_type":"closed access","article_processing_charge":"No","_id":"20039","date_created":"2025-07-20T22:02:04Z","day":"01","year":"2024","volume":2,"month":"10","quality_controlled":"1","author":[{"full_name":"Neidhart, Maja","last_name":"Neidhart","first_name":"Maja"},{"first_name":"Rikka","last_name":"Kjelkenes","full_name":"Kjelkenes, Rikka"},{"full_name":"Jansone, Karina","first_name":"Karina","last_name":"Jansone"},{"full_name":"Rehák Bučková, Barbora","last_name":"Rehák Bučková","first_name":"Barbora"},{"last_name":"Holz","first_name":"Nathalie","full_name":"Holz, Nathalie"},{"last_name":"Nees","first_name":"Frauke","full_name":"Nees, Frauke"},{"last_name":"Walter","first_name":"Henrik","full_name":"Walter, Henrik"},{"full_name":"Schumann, Gunter","first_name":"Gunter","last_name":"Schumann"},{"full_name":"Rapp, Michael A.","first_name":"Michael A.","last_name":"Rapp"},{"last_name":"Banaschewski","first_name":"Tobias","full_name":"Banaschewski, Tobias"},{"last_name":"Schwarz","first_name":"Emanuel","full_name":"Schwarz, Emanuel"},{"full_name":"Marquand, Andre","first_name":"Andre","last_name":"Marquand"},{"full_name":"Ogoh, George","first_name":"George","last_name":"Ogoh"},{"full_name":"Stahl, Bernd","first_name":"Bernd","last_name":"Stahl"},{"first_name":"Allan H.","last_name":"Young","full_name":"Young, Allan H."},{"full_name":"Desrivières, Sylvane","first_name":"Sylvane","last_name":"Desrivières"},{"full_name":"Clinton, Nicholas","first_name":"Nicholas","last_name":"Clinton"},{"full_name":"Thompson, Paul","first_name":"Paul","last_name":"Thompson"},{"first_name":"Ameli","last_name":"Schwalber","full_name":"Schwalber, Ameli"},{"last_name":"Liu","first_name":"Jingyu","full_name":"Liu, Jingyu"},{"last_name":"Calhoun","first_name":"Vince","full_name":"Calhoun, Vince"},{"first_name":"Xiao","last_name":"Chang","full_name":"Chang, Xiao"},{"full_name":"Xia, Yunman","last_name":"Xia","first_name":"Yunman"},{"full_name":"Gong, Yanting","first_name":"Yanting","last_name":"Gong"},{"full_name":"Jia, Tianye","first_name":"Tianye","last_name":"Jia"},{"first_name":"Paul","last_name":"Renner","full_name":"Renner, Paul"},{"full_name":"Hese, Sören","last_name":"Hese","first_name":"Sören"},{"full_name":"Giner, Arantxa","first_name":"Arantxa","last_name":"Giner"},{"full_name":"Sanchez, Mavi","first_name":"Mavi","last_name":"Sanchez"},{"full_name":"Alvarez, Elena","last_name":"Alvarez","first_name":"Elena"},{"first_name":"Bernhard","last_name":"Spanlang","full_name":"Spanlang, Bernhard"},{"full_name":"Pearmund, Charlie","last_name":"Pearmund","first_name":"Charlie"},{"first_name":"Anastasios Polykarpos","last_name":"Athanasiadis","full_name":"Athanasiadis, Anastasios Polykarpos"},{"last_name":"Otten","first_name":"Lisa","full_name":"Otten, Lisa"},{"full_name":"Pitel, Séverine","last_name":"Pitel","first_name":"Séverine"},{"full_name":"Petkoski, Spase","first_name":"Spase","last_name":"Petkoski"},{"last_name":"Jirsa","first_name":"Viktor","full_name":"Jirsa, Viktor"},{"first_name":"Karen","last_name":"Schmitt","full_name":"Schmitt, Karen"},{"first_name":"Johannes","last_name":"Wilbertz","full_name":"Wilbertz, Johannes"},{"last_name":"Patraskaki","first_name":"Myrto","full_name":"Patraskaki, Myrto"},{"full_name":"Sommer, Peter","last_name":"Sommer","first_name":"Peter"},{"last_name":"Heilmann-Heimbach","first_name":"Stefanie","full_name":"Heilmann-Heimbach, Stefanie"},{"full_name":"Mathey, Carina M.","last_name":"Mathey","first_name":"Carina M."},{"full_name":"Miller, Abigail","last_name":"Miller","first_name":"Abigail"},{"last_name":"Claus","first_name":"Isabelle","full_name":"Claus, Isabelle"},{"full_name":"Nöthen, Markus M.","last_name":"Nöthen","first_name":"Markus M."},{"full_name":"Hoffmann, Per","first_name":"Per","last_name":"Hoffmann"},{"full_name":"Forstner, Andreas J.","last_name":"Forstner","first_name":"Andreas J."},{"full_name":"Pastor, Alvaro","first_name":"Alvaro","last_name":"Pastor"},{"full_name":"Gallego, Jaime","first_name":"Jaime","last_name":"Gallego"},{"full_name":"Orosa, Francisco Eiroa","last_name":"Orosa","first_name":"Francisco Eiroa"},{"full_name":"Viapiana, Guillem Feixas","last_name":"Viapiana","first_name":"Guillem Feixas"},{"last_name":"Slater","first_name":"Mel","full_name":"Slater, Mel"},{"full_name":"Marr, Lena","id":"4406F586-F248-11E8-B48F-1D18A9856A87","last_name":"Marr","first_name":"Lena"},{"last_name":"Novarino","first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia"},{"last_name":"Böttger","first_name":"Sarah Jane","full_name":"Böttger, Sarah Jane"},{"full_name":"Tschorn, Mira","last_name":"Tschorn","first_name":"Mira"},{"first_name":"Michael","last_name":"Rapp","full_name":"Rapp, Michael"},{"last_name":"Ask","first_name":"Helga","full_name":"Ask, Helga"},{"full_name":"Fernandez, Sara","last_name":"Fernandez","first_name":"Sara"},{"full_name":"Van Der Meer, Dennis","last_name":"Van Der Meer","first_name":"Dennis"},{"last_name":"Westlye","first_name":"Lars T.","full_name":"Westlye, Lars T."},{"full_name":"Andreassen, Ole A.","first_name":"Ole A.","last_name":"Andreassen"},{"first_name":"Rieke","last_name":"Aden","full_name":"Aden, Rieke"},{"full_name":"Seefried, Beke","first_name":"Beke","last_name":"Seefried"},{"last_name":"Siehl","first_name":"Sebastian","full_name":"Siehl, Sebastian"},{"full_name":"Nees, Frauke","last_name":"Nees","first_name":"Frauke"},{"full_name":"Stringaris, Argyris","last_name":"Stringaris","first_name":"Argyris"},{"full_name":"Tost, Heike","first_name":"Heike","last_name":"Tost"},{"last_name":"Meyer-Lindenberg","first_name":"Andreas","full_name":"Meyer-Lindenberg, Andreas"},{"first_name":"Nina","last_name":"Christmann","full_name":"Christmann, Nina"},{"full_name":"Banks, Jamie","last_name":"Banks","first_name":"Jamie"},{"full_name":"Schepanski, Kerstin","last_name":"Schepanski","first_name":"Kerstin"},{"first_name":"Tatjana","last_name":"Schütz","full_name":"Schütz, Tatjana"},{"full_name":"Taron, Ulrike Helene","last_name":"Taron","first_name":"Ulrike Helene"},{"first_name":"Roland","last_name":"Eils","full_name":"Eils, Roland"},{"first_name":"Jean Charles","last_name":"Roy","full_name":"Roy, Jean Charles"},{"full_name":"Lett, Tristram A.","first_name":"Tristram A.","last_name":"Lett"},{"first_name":"Hedi","last_name":"Kebir","full_name":"Kebir, Hedi"},{"first_name":"Elli","last_name":"Polemiti","full_name":"Polemiti, Elli"},{"full_name":"Hitchen, Esther","first_name":"Esther","last_name":"Hitchen"},{"last_name":"Jentsch","first_name":"Marcel","full_name":"Jentsch, Marcel"},{"full_name":"Serin, Emin","last_name":"Serin","first_name":"Emin"},{"last_name":"Bernas","first_name":"Antoine","full_name":"Bernas, Antoine"},{"first_name":"Nilakshi","last_name":"Vaidya","full_name":"Vaidya, Nilakshi"},{"first_name":"Sven","last_name":"Twardziok","full_name":"Twardziok, Sven"},{"full_name":"Ralser, Markus","last_name":"Ralser","first_name":"Markus"},{"last_name":"Heinz","first_name":"Andreas","full_name":"Heinz, Andreas"}],"publication":"Nature Mental Health","citation":{"ama":"Neidhart M, Kjelkenes R, Jansone K, et al. A protocol for data harmonization in large cohorts. <i>Nature Mental Health</i>. 2024;2(10):1134-1137. doi:<a href=\"https://doi.org/10.1038/s44220-024-00315-0\">10.1038/s44220-024-00315-0</a>","mla":"Neidhart, Maja, et al. “A Protocol for Data Harmonization in Large Cohorts.” <i>Nature Mental Health</i>, vol. 2, no. 10, Springer Nature, 2024, pp. 1134–37, doi:<a href=\"https://doi.org/10.1038/s44220-024-00315-0\">10.1038/s44220-024-00315-0</a>.","ista":"Neidhart M, Kjelkenes R, Jansone K, Rehák Bučková B, Holz N, Nees F, Walter H, Schumann G, Rapp MA, Banaschewski T, Schwarz E, Marquand A, Ogoh G, Stahl B, Young AH, Desrivières S, Clinton N, Thompson P, Schwalber A, Liu J, Calhoun V, Chang X, Xia Y, Gong Y, Jia T, Renner P, Hese S, Giner A, Sanchez M, Alvarez E, Spanlang B, Pearmund C, Athanasiadis AP, Otten L, Pitel S, Petkoski S, Jirsa V, Schmitt K, Wilbertz J, Patraskaki M, Sommer P, Heilmann-Heimbach S, Mathey CM, Miller A, Claus I, Nöthen MM, Hoffmann P, Forstner AJ, Pastor A, Gallego J, Orosa FE, Viapiana GF, Slater M, Marr L, Novarino G, Böttger SJ, Tschorn M, Rapp M, Ask H, Fernandez S, Van Der Meer D, Westlye LT, Andreassen OA, Aden R, Seefried B, Siehl S, Nees F, Stringaris A, Tost H, Meyer-Lindenberg A, Christmann N, Banks J, Schepanski K, Schütz T, Taron UH, Eils R, Roy JC, Lett TA, Kebir H, Polemiti E, Hitchen E, Jentsch M, Serin E, Bernas A, Vaidya N, Twardziok S, Ralser M, Heinz A. 2024. A protocol for data harmonization in large cohorts. Nature Mental Health. 2(10), 1134–1137.","ieee":"M. Neidhart <i>et al.</i>, “A protocol for data harmonization in large cohorts,” <i>Nature Mental Health</i>, vol. 2, no. 10. Springer Nature, pp. 1134–1137, 2024.","chicago":"Neidhart, Maja, Rikka Kjelkenes, Karina Jansone, Barbora Rehák Bučková, Nathalie Holz, Frauke Nees, Henrik Walter, et al. “A Protocol for Data Harmonization in Large Cohorts.” <i>Nature Mental Health</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s44220-024-00315-0\">https://doi.org/10.1038/s44220-024-00315-0</a>.","short":"M. Neidhart, R. Kjelkenes, K. Jansone, B. Rehák Bučková, N. Holz, F. Nees, H. Walter, G. Schumann, M.A. Rapp, T. Banaschewski, E. Schwarz, A. Marquand, G. Ogoh, B. Stahl, A.H. Young, S. Desrivières, N. Clinton, P. Thompson, A. Schwalber, J. Liu, V. Calhoun, X. Chang, Y. Xia, Y. Gong, T. Jia, P. Renner, S. Hese, A. Giner, M. Sanchez, E. Alvarez, B. Spanlang, C. Pearmund, A.P. Athanasiadis, L. Otten, S. Pitel, S. Petkoski, V. Jirsa, K. Schmitt, J. Wilbertz, M. Patraskaki, P. Sommer, S. Heilmann-Heimbach, C.M. Mathey, A. Miller, I. Claus, M.M. Nöthen, P. Hoffmann, A.J. Forstner, A. Pastor, J. Gallego, F.E. Orosa, G.F. Viapiana, M. Slater, L. Marr, G. Novarino, S.J. Böttger, M. Tschorn, M. Rapp, H. Ask, S. Fernandez, D. Van Der Meer, L.T. Westlye, O.A. Andreassen, R. Aden, B. Seefried, S. Siehl, F. Nees, A. Stringaris, H. Tost, A. Meyer-Lindenberg, N. Christmann, J. Banks, K. Schepanski, T. Schütz, U.H. Taron, R. Eils, J.C. Roy, T.A. Lett, H. Kebir, E. Polemiti, E. Hitchen, M. Jentsch, E. Serin, A. Bernas, N. Vaidya, S. Twardziok, M. Ralser, A. Heinz, Nature Mental Health 2 (2024) 1134–1137.","apa":"Neidhart, M., Kjelkenes, R., Jansone, K., Rehák Bučková, B., Holz, N., Nees, F., … Heinz, A. (2024). A protocol for data harmonization in large cohorts. <i>Nature Mental Health</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s44220-024-00315-0\">https://doi.org/10.1038/s44220-024-00315-0</a>"},"abstract":[{"lang":"eng","text":"This Comment presents a high-level protocol for data harmonization within large cohorts, in which it postulates four main steps including (1) expert review, (2) pre-statistical harmonization, (3) statistical harmonization, and (4) validation."}],"publisher":"Springer Nature","date_published":"2024-10-01T00:00:00Z","acknowledgement":"Funded by the European Union. Complementary funding was received by UK Research and Innovation (UKRI) under the UK government’s Horizon Europe funding guarantee (10041392 and 10038599). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union, the European Health and Digital Executive Agency (HADEA) or UKRI. The European Union, HADEA or UKRI cannot be held responsible for them. This work received support from the Chinese Ministry for Science and Technology (MOST), the Horizon 2020-funded European Research Council advanced grant ‘STRATIFY’ (695313); the German Research Foundation (COPE; 675346; NE 1383/15-1 and BA 2088/7-1 (CoviDrug)), the National Natural Science Foundation of China grant 82150710554, the Hector II foundation and the German Center for Mental Health (DZPG) (01EE2301A, 01EE2304A, 01EE2301D).","publication_identifier":{"eissn":["2731-6076"]}},{"status":"public","publication_status":"published","issue":"10","date_updated":"2025-08-11T06:44:03Z","intvolume":"         2","doi":"10.1038/s44220-024-00317-y","scopus_import":"1","language":[{"iso":"eng"}],"OA_type":"closed access","article_processing_charge":"No","_id":"20156","title":"Multi-omics analyses of the environMENTAL project provide insights into mental health and disease","department":[{"_id":"GaNo"}],"type":"journal_article","oa_version":"None","article_type":"comment","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"1131-1133","citation":{"chicago":"Desrivières, Sylvane, Abigail Miller, Carina M. Mathey, Xinyang Yu, Di Chen, Kofoworola Agunbiade, Stefanie Heilmann-Heimbach, et al. “Multi-Omics Analyses of the EnvironMENTAL Project Provide Insights into Mental Health and Disease.” <i>Nature Mental Health</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s44220-024-00317-y\">https://doi.org/10.1038/s44220-024-00317-y</a>.","short":"S. Desrivières, A. Miller, C.M. Mathey, X. Yu, D. Chen, K. Agunbiade, S. Heilmann-Heimbach, A.J. Forstner, G. Schumann, P. Hoffmann, M.M. Nöthen, G. Ogoh, B. Stahl, A.H. Young, N. Clinton, P. Thompson, A. Schwalber, J. Liu, V. Calhoun, X. Chang, Y. Xia, Y. Gong, T. Jia, P. Renner, S. Hese, A. Giner, M. Sanchez, E. Alvarez, B. Spanlang, C. Pearmund, A.P. Athanasiadis, L. Otten, S. Pitel, S. Petkoski, V. Jirsa, K. Schmitt, J. Wilbertz, M. Patraskaki, P. Sommer, I. Claus, A. Pastor, J. Gallego, F.E. Orosa, G.F. Viapiana, M. Slater, L. Marr, G. Novarino, A. Marquand, S.J. Böttger, M. Tschorn, M. Rapp, H. Ask, R. Kjelkenes, S. Fernandez, D. Van Der Meer, L.T. Westlye, O.A. Andreassen, R. Aden, B. Seefried, S. Siehl, F. Nees, M. Neidhart, A. Stringaris, E. Schwarz, N. Holz, H. Tost, A. Meyer-Lindenberg, N. Christmann, K. Jansone, T. Banaschewski, J. Banks, K. Schepanski, T. Schütz, U.H. Taron, R. Eils, J.C. Roy, T.A. Lett, H. Kebir, E. Polemiti, E. Hitchen, M. Jentsch, E. Serin, A. Bernas, N. Vaidya, S. Twardziok, M. Ralser, A. Heinz, H. Walter, Nature Mental Health 2 (2024) 1131–1133.","apa":"Desrivières, S., Miller, A., Mathey, C. M., Yu, X., Chen, D., Agunbiade, K., … Walter, H. (2024). Multi-omics analyses of the environMENTAL project provide insights into mental health and disease. <i>Nature Mental Health</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s44220-024-00317-y\">https://doi.org/10.1038/s44220-024-00317-y</a>","ieee":"S. Desrivières <i>et al.</i>, “Multi-omics analyses of the environMENTAL project provide insights into mental health and disease,” <i>Nature Mental Health</i>, vol. 2, no. 10. Springer Nature, pp. 1131–1133, 2024.","ista":"Desrivières S, Miller A, Mathey CM, Yu X, Chen D, Agunbiade K, Heilmann-Heimbach S, Forstner AJ, Schumann G, Hoffmann P, Nöthen MM, Ogoh G, Stahl B, Young AH, Clinton N, Thompson P, Schwalber A, Liu J, Calhoun V, Chang X, Xia Y, Gong Y, Jia T, Renner P, Hese S, Giner A, Sanchez M, Alvarez E, Spanlang B, Pearmund C, Athanasiadis AP, Otten L, Pitel S, Petkoski S, Jirsa V, Schmitt K, Wilbertz J, Patraskaki M, Sommer P, Claus I, Pastor A, Gallego J, Orosa FE, Viapiana GF, Slater M, Marr L, Novarino G, Marquand A, Böttger SJ, Tschorn M, Rapp M, Ask H, Kjelkenes R, Fernandez S, Van Der Meer D, Westlye LT, Andreassen OA, Aden R, Seefried B, Siehl S, Nees F, Neidhart M, Stringaris A, Schwarz E, Holz N, Tost H, Meyer-Lindenberg A, Christmann N, Jansone K, Banaschewski T, Banks J, Schepanski K, Schütz T, Taron UH, Eils R, Roy JC, Lett TA, Kebir H, Polemiti E, Hitchen E, Jentsch M, Serin E, Bernas A, Vaidya N, Twardziok S, Ralser M, Heinz A, Walter H. 2024. Multi-omics analyses of the environMENTAL project provide insights into mental health and disease. Nature Mental Health. 2(10), 1131–1133.","ama":"Desrivières S, Miller A, Mathey CM, et al. Multi-omics analyses of the environMENTAL project provide insights into mental health and disease. <i>Nature Mental Health</i>. 2024;2(10):1131-1133. doi:<a href=\"https://doi.org/10.1038/s44220-024-00317-y\">10.1038/s44220-024-00317-y</a>","mla":"Desrivières, Sylvane, et al. “Multi-Omics Analyses of the EnvironMENTAL Project Provide Insights into Mental Health and Disease.” <i>Nature Mental Health</i>, vol. 2, no. 10, Springer Nature, 2024, pp. 1131–33, doi:<a href=\"https://doi.org/10.1038/s44220-024-00317-y\">10.1038/s44220-024-00317-y</a>."},"abstract":[{"text":"Integrative analyses that incorporate different levels of ‘-omics’ data represent a powerful tool for deciphering the biological mechanisms that underlie environmental influences on mental health and disease. This Comment highlights various aspects of such multi-omics approaches, using the example of the EU-funded environMENTAL project.","lang":"eng"}],"publication":"Nature Mental Health","date_published":"2024-10-01T00:00:00Z","acknowledgement":"This work was supported by the Horizon 2021 (grant 101057429) and UK Research and Innovation (grants 10038599 and 10041392)-funded project environMENTAL. Other funding included the Medical Research Council and Medical Research Foundation (MR/R00465X/, MRF-058-0004-RG-DESRI, ‘ESTRA’- Neurobiological underpinning of eating disorders: integrative biopsychosocial longitudinal analyses in adolescents; and MR/S020306/1, MRF-058-0009-RG-DESR-C0759 ‘ESTRA’-Establishing causal relationships between biopsychosocial predictors and correlates of eating disorders and their mediation by neural pathways), the EU-funded FP6 Integrated Project IMAGEN (reinforcement-related behavior in normal brain function and psychopathology; LSHM-CT- 2007-037286), the Horizon 2020-funded European Research Council advanced grant for STRATIFY (brain network-based stratification of reinforcement-related disorders; 695313) and the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. This paper represents independent research, partly funded by the NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. The authors thank C. Schmäl for proofreading the manuscript.","publication_identifier":{"eissn":["2731-6076"]},"publisher":"Springer Nature","volume":2,"date_created":"2025-08-10T22:01:30Z","day":"01","year":"2024","month":"10","quality_controlled":"1","author":[{"full_name":"Desrivières, Sylvane","first_name":"Sylvane","last_name":"Desrivières"},{"last_name":"Miller","first_name":"Abigail","full_name":"Miller, Abigail"},{"last_name":"Mathey","first_name":"Carina M.","full_name":"Mathey, Carina M."},{"full_name":"Yu, Xinyang","first_name":"Xinyang","last_name":"Yu"},{"first_name":"Di","last_name":"Chen","full_name":"Chen, Di"},{"last_name":"Agunbiade","first_name":"Kofoworola","full_name":"Agunbiade, Kofoworola"},{"full_name":"Heilmann-Heimbach, Stefanie","first_name":"Stefanie","last_name":"Heilmann-Heimbach"},{"full_name":"Forstner, Andreas J.","last_name":"Forstner","first_name":"Andreas J."},{"last_name":"Schumann","first_name":"Gunter","full_name":"Schumann, Gunter"},{"full_name":"Hoffmann, Per","first_name":"Per","last_name":"Hoffmann"},{"last_name":"Nöthen","first_name":"Markus M.","full_name":"Nöthen, Markus M."},{"last_name":"Ogoh","first_name":"George","full_name":"Ogoh, George"},{"last_name":"Stahl","first_name":"Bernd","full_name":"Stahl, Bernd"},{"first_name":"Allan H.","last_name":"Young","full_name":"Young, Allan H."},{"full_name":"Clinton, Nicholas","first_name":"Nicholas","last_name":"Clinton"},{"last_name":"Thompson","first_name":"Paul","full_name":"Thompson, Paul"},{"last_name":"Schwalber","first_name":"Ameli","full_name":"Schwalber, Ameli"},{"full_name":"Liu, Jingyu","last_name":"Liu","first_name":"Jingyu"},{"first_name":"Vince","last_name":"Calhoun","full_name":"Calhoun, Vince"},{"last_name":"Chang","first_name":"Xiao","full_name":"Chang, Xiao"},{"first_name":"Yunman","last_name":"Xia","full_name":"Xia, Yunman"},{"full_name":"Gong, Yanting","last_name":"Gong","first_name":"Yanting"},{"full_name":"Jia, Tianye","first_name":"Tianye","last_name":"Jia"},{"last_name":"Renner","first_name":"Paul","full_name":"Renner, Paul"},{"last_name":"Hese","first_name":"Sören","full_name":"Hese, Sören"},{"full_name":"Giner, Arantxa","last_name":"Giner","first_name":"Arantxa"},{"full_name":"Sanchez, Mavi","last_name":"Sanchez","first_name":"Mavi"},{"first_name":"Elena","last_name":"Alvarez","full_name":"Alvarez, Elena"},{"last_name":"Spanlang","first_name":"Bernhard","full_name":"Spanlang, Bernhard"},{"last_name":"Pearmund","first_name":"Charlie","full_name":"Pearmund, Charlie"},{"first_name":"Anastasios Polykarpos","last_name":"Athanasiadis","full_name":"Athanasiadis, Anastasios Polykarpos"},{"first_name":"Lisa","last_name":"Otten","full_name":"Otten, Lisa"},{"full_name":"Pitel, Séverine","first_name":"Séverine","last_name":"Pitel"},{"full_name":"Petkoski, Spase","first_name":"Spase","last_name":"Petkoski"},{"full_name":"Jirsa, Viktor","first_name":"Viktor","last_name":"Jirsa"},{"full_name":"Schmitt, Karen","last_name":"Schmitt","first_name":"Karen"},{"first_name":"Johannes","last_name":"Wilbertz","full_name":"Wilbertz, Johannes"},{"full_name":"Patraskaki, Myrto","first_name":"Myrto","last_name":"Patraskaki"},{"first_name":"Peter","last_name":"Sommer","full_name":"Sommer, Peter"},{"last_name":"Claus","first_name":"Isabelle","full_name":"Claus, Isabelle"},{"full_name":"Pastor, Alvaro","last_name":"Pastor","first_name":"Alvaro"},{"full_name":"Gallego, Jaime","last_name":"Gallego","first_name":"Jaime"},{"first_name":"Francisco Eiroa","last_name":"Orosa","full_name":"Orosa, Francisco Eiroa"},{"first_name":"Guillem Feixas","last_name":"Viapiana","full_name":"Viapiana, Guillem Feixas"},{"first_name":"Mel","last_name":"Slater","full_name":"Slater, Mel"},{"id":"4406F586-F248-11E8-B48F-1D18A9856A87","first_name":"Lena","last_name":"Marr","full_name":"Marr, Lena"},{"first_name":"Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia"},{"full_name":"Marquand, Andre","last_name":"Marquand","first_name":"Andre"},{"full_name":"Böttger, Sarah Jane","first_name":"Sarah Jane","last_name":"Böttger"},{"last_name":"Tschorn","first_name":"Mira","full_name":"Tschorn, Mira"},{"full_name":"Rapp, Michael","first_name":"Michael","last_name":"Rapp"},{"last_name":"Ask","first_name":"Helga","full_name":"Ask, Helga"},{"full_name":"Kjelkenes, Rikka","first_name":"Rikka","last_name":"Kjelkenes"},{"last_name":"Fernandez","first_name":"Sara","full_name":"Fernandez, Sara"},{"first_name":"Dennis","last_name":"Van Der Meer","full_name":"Van Der Meer, Dennis"},{"last_name":"Westlye","first_name":"Lars T.","full_name":"Westlye, Lars T."},{"last_name":"Andreassen","first_name":"Ole A.","full_name":"Andreassen, Ole A."},{"last_name":"Aden","first_name":"Rieke","full_name":"Aden, Rieke"},{"first_name":"Beke","last_name":"Seefried","full_name":"Seefried, Beke"},{"full_name":"Siehl, Sebastian","first_name":"Sebastian","last_name":"Siehl"},{"full_name":"Nees, Frauke","last_name":"Nees","first_name":"Frauke"},{"full_name":"Neidhart, Maja","last_name":"Neidhart","first_name":"Maja"},{"full_name":"Stringaris, Argyris","first_name":"Argyris","last_name":"Stringaris"},{"first_name":"Emanuel","last_name":"Schwarz","full_name":"Schwarz, Emanuel"},{"full_name":"Holz, Nathalie","last_name":"Holz","first_name":"Nathalie"},{"first_name":"Heike","last_name":"Tost","full_name":"Tost, Heike"},{"last_name":"Meyer-Lindenberg","first_name":"Andreas","full_name":"Meyer-Lindenberg, Andreas"},{"first_name":"Nina","last_name":"Christmann","full_name":"Christmann, Nina"},{"full_name":"Jansone, Karina","first_name":"Karina","last_name":"Jansone"},{"first_name":"Tobias","last_name":"Banaschewski","full_name":"Banaschewski, Tobias"},{"last_name":"Banks","first_name":"Jamie","full_name":"Banks, Jamie"},{"first_name":"Kerstin","last_name":"Schepanski","full_name":"Schepanski, Kerstin"},{"full_name":"Schütz, Tatjana","first_name":"Tatjana","last_name":"Schütz"},{"first_name":"Ulrike Helene","last_name":"Taron","full_name":"Taron, Ulrike Helene"},{"full_name":"Eils, Roland","first_name":"Roland","last_name":"Eils"},{"first_name":"Jean Charles","last_name":"Roy","full_name":"Roy, Jean Charles"},{"full_name":"Lett, Tristram A.","first_name":"Tristram A.","last_name":"Lett"},{"full_name":"Kebir, Hedi","first_name":"Hedi","last_name":"Kebir"},{"first_name":"Elli","last_name":"Polemiti","full_name":"Polemiti, Elli"},{"full_name":"Hitchen, Esther","first_name":"Esther","last_name":"Hitchen"},{"full_name":"Jentsch, Marcel","first_name":"Marcel","last_name":"Jentsch"},{"last_name":"Serin","first_name":"Emin","full_name":"Serin, Emin"},{"first_name":"Antoine","last_name":"Bernas","full_name":"Bernas, Antoine"},{"full_name":"Vaidya, Nilakshi","first_name":"Nilakshi","last_name":"Vaidya"},{"full_name":"Twardziok, Sven","first_name":"Sven","last_name":"Twardziok"},{"last_name":"Ralser","first_name":"Markus","full_name":"Ralser, Markus"},{"first_name":"Andreas","last_name":"Heinz","full_name":"Heinz, Andreas"},{"first_name":"Henrik","last_name":"Walter","full_name":"Walter, Henrik"}]},{"publisher":"Springer Nature","acknowledgement":"Funded provided by the European Union. Complementary funding was received by UK Research and Innovation (UKRI) under the UK government’s Horizon Europe funding guarantee (10131373and 10038599) and Ministry of Science and Technology of China (MOST) National Key Project of ‘Inter-governmental International Scientific and Technological Innovation Cooperation’ (2023YFE0199700).","date_published":"2024-10-01T00:00:00Z","publication_identifier":{"eissn":["2731-6076"]},"publication":"Nature Mental Health","abstract":[{"text":"The focus of much of contemporary research ethics is on compliance with established protocols. However, large data-driven neuroscience research raises new ethical concerns that have no agreed-upon solution. Here we reflect on these challenges and propose better integration of public and patient involvement in this evolving landscape.","lang":"eng"}],"citation":{"short":"B. Stahl, G. Ogoh, G. Schumann, H. Walter, B. Stahl, A.H. Young, S. Desrivières, N. Clinton, P. Thompson, A. Schwalber, J. Liu, V. Calhoun, X. Chang, Y. Xia, Y. Gong, T. Jia, P. Renner, S. Hese, A. Giner, M. Sanchez, E. Alvarez, B. Spanlang, C. Pearmund, A.P. Athanasiadis, L. Otten, S. Pitel, S. Petkoski, V. Jirsa, K. Schmitt, J. Wilbertz, M. Patraskaki, P. Sommer, S. Heilmann-Heimbach, C.M. Mathey, A. Miller, I. Claus, M.M. Nöthen, P. Hoffmann, A.J. Forstner, A. Pastor, J. Gallego, F.E. Orosa, G.F. Viapiana, M. Slater, L. Marr, G. Novarino, A. Marquand, S.J. Böttger, M. Tschorn, M. Rapp, H. Ask, R. Kjelkenes, S. Fernandez, D. Van Der Meer, L.T. Westlye, O.A. Andreassen, R. Aden, B. Seefried, S. Siehl, F. Nees, M. Neidhart, A. Stringaris, E. Schwarz, N. Holz, H. Tost, A. Meyer-Lindenberg, N. Christmann, K. Jansone, T. Banaschewski, J. Banks, K. Schepanski, T. Schütz, U.H. Taron, R. Eils, J.C. Roy, T.A. Lett, H. Kebir, E. Polemiti, E. Hitchen, M. Jentsch, E. Serin, A. Bernas, N. Vaidya, S. Twardziok, M. Ralser, A. Heinz, H. Walter, Nature Mental Health 2 (2024).","chicago":"Stahl, Bernd, George Ogoh, Gunter Schumann, Henrik Walter, Bernd Stahl, Allan H. Young, Sylvane Desrivières, et al. “Rethinking Ethics in Interdisciplinary and Big Data-Driven Neuroscience Projects.” <i>Nature Mental Health</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s44220-024-00320-3\">https://doi.org/10.1038/s44220-024-00320-3</a>.","apa":"Stahl, B., Ogoh, G., Schumann, G., Walter, H., Stahl, B., Young, A. H., … Walter, H. (2024). Rethinking ethics in interdisciplinary and big data-driven neuroscience projects. <i>Nature Mental Health</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s44220-024-00320-3\">https://doi.org/10.1038/s44220-024-00320-3</a>","ieee":"B. Stahl <i>et al.</i>, “Rethinking ethics in interdisciplinary and big data-driven neuroscience projects,” <i>Nature Mental Health</i>, vol. 2, no. 10. Springer Nature, 2024.","ista":"Stahl B, Ogoh G, Schumann G, Walter H, Stahl B, Young AH, Desrivières S, Clinton N, Thompson P, Schwalber A, Liu J, Calhoun V, Chang X, Xia Y, Gong Y, Jia T, Renner P, Hese S, Giner A, Sanchez M, Alvarez E, Spanlang B, Pearmund C, Athanasiadis AP, Otten L, Pitel S, Petkoski S, Jirsa V, Schmitt K, Wilbertz J, Patraskaki M, Sommer P, Heilmann-Heimbach S, Mathey CM, Miller A, Claus I, Nöthen MM, Hoffmann P, Forstner AJ, Pastor A, Gallego J, Orosa FE, Viapiana GF, Slater M, Marr L, Novarino G, Marquand A, Böttger SJ, Tschorn M, Rapp M, Ask H, Kjelkenes R, Fernandez S, Van Der Meer D, Westlye LT, Andreassen OA, Aden R, Seefried B, Siehl S, Nees F, Neidhart M, Stringaris A, Schwarz E, Holz N, Tost H, Meyer-Lindenberg A, Christmann N, Jansone K, Banaschewski T, Banks J, Schepanski K, Schütz T, Taron UH, Eils R, Roy JC, Lett TA, Kebir H, Polemiti E, Hitchen E, Jentsch M, Serin E, Bernas A, Vaidya N, Twardziok S, Ralser M, Heinz A, Walter H. 2024. Rethinking ethics in interdisciplinary and big data-driven neuroscience projects. Nature Mental Health. 2(10), 1128–1130.","ama":"Stahl B, Ogoh G, Schumann G, et al. Rethinking ethics in interdisciplinary and big data-driven neuroscience projects. <i>Nature Mental Health</i>. 2024;2(10). doi:<a href=\"https://doi.org/10.1038/s44220-024-00320-3\">10.1038/s44220-024-00320-3</a>","mla":"Stahl, Bernd, et al. “Rethinking Ethics in Interdisciplinary and Big Data-Driven Neuroscience Projects.” <i>Nature Mental Health</i>, vol. 2, no. 10, 1128–1130, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1038/s44220-024-00320-3\">10.1038/s44220-024-00320-3</a>."},"quality_controlled":"1","author":[{"full_name":"Stahl, Bernd","last_name":"Stahl","first_name":"Bernd"},{"last_name":"Ogoh","first_name":"George","full_name":"Ogoh, George"},{"first_name":"Gunter","last_name":"Schumann","full_name":"Schumann, Gunter"},{"full_name":"Walter, Henrik","first_name":"Henrik","last_name":"Walter"},{"first_name":"Bernd","last_name":"Stahl","full_name":"Stahl, Bernd"},{"full_name":"Young, Allan H.","first_name":"Allan H.","last_name":"Young"},{"full_name":"Desrivières, Sylvane","first_name":"Sylvane","last_name":"Desrivières"},{"full_name":"Clinton, Nicholas","last_name":"Clinton","first_name":"Nicholas"},{"last_name":"Thompson","first_name":"Paul","full_name":"Thompson, Paul"},{"first_name":"Ameli","last_name":"Schwalber","full_name":"Schwalber, Ameli"},{"last_name":"Liu","first_name":"Jingyu","full_name":"Liu, Jingyu"},{"last_name":"Calhoun","first_name":"Vince","full_name":"Calhoun, Vince"},{"first_name":"Xiao","last_name":"Chang","full_name":"Chang, Xiao"},{"full_name":"Xia, Yunman","first_name":"Yunman","last_name":"Xia"},{"full_name":"Gong, Yanting","first_name":"Yanting","last_name":"Gong"},{"full_name":"Jia, Tianye","first_name":"Tianye","last_name":"Jia"},{"full_name":"Renner, Paul","first_name":"Paul","last_name":"Renner"},{"last_name":"Hese","first_name":"Sören","full_name":"Hese, Sören"},{"last_name":"Giner","first_name":"Arantxa","full_name":"Giner, Arantxa"},{"last_name":"Sanchez","first_name":"Mavi","full_name":"Sanchez, Mavi"},{"full_name":"Alvarez, Elena","first_name":"Elena","last_name":"Alvarez"},{"full_name":"Spanlang, Bernhard","last_name":"Spanlang","first_name":"Bernhard"},{"full_name":"Pearmund, Charlie","first_name":"Charlie","last_name":"Pearmund"},{"full_name":"Athanasiadis, Anastasios Polykarpos","first_name":"Anastasios Polykarpos","last_name":"Athanasiadis"},{"full_name":"Otten, Lisa","last_name":"Otten","first_name":"Lisa"},{"full_name":"Pitel, Séverine","first_name":"Séverine","last_name":"Pitel"},{"full_name":"Petkoski, Spase","last_name":"Petkoski","first_name":"Spase"},{"full_name":"Jirsa, Viktor","first_name":"Viktor","last_name":"Jirsa"},{"last_name":"Schmitt","first_name":"Karen","full_name":"Schmitt, Karen"},{"full_name":"Wilbertz, Johannes","last_name":"Wilbertz","first_name":"Johannes"},{"first_name":"Myrto","last_name":"Patraskaki","full_name":"Patraskaki, Myrto"},{"full_name":"Sommer, Peter","last_name":"Sommer","first_name":"Peter"},{"last_name":"Heilmann-Heimbach","first_name":"Stefanie","full_name":"Heilmann-Heimbach, Stefanie"},{"full_name":"Mathey, Carina M.","first_name":"Carina M.","last_name":"Mathey"},{"first_name":"Abigail","last_name":"Miller","full_name":"Miller, Abigail"},{"full_name":"Claus, Isabelle","first_name":"Isabelle","last_name":"Claus"},{"last_name":"Nöthen","first_name":"Markus M.","full_name":"Nöthen, Markus M."},{"last_name":"Hoffmann","first_name":"Per","full_name":"Hoffmann, Per"},{"full_name":"Forstner, Andreas J.","first_name":"Andreas J.","last_name":"Forstner"},{"first_name":"Alvaro","last_name":"Pastor","full_name":"Pastor, Alvaro"},{"last_name":"Gallego","first_name":"Jaime","full_name":"Gallego, Jaime"},{"last_name":"Orosa","first_name":"Francisco Eiroa","full_name":"Orosa, Francisco Eiroa"},{"full_name":"Viapiana, Guillem Feixas","last_name":"Viapiana","first_name":"Guillem Feixas"},{"full_name":"Slater, Mel","last_name":"Slater","first_name":"Mel"},{"full_name":"Marr, Lena","id":"4406F586-F248-11E8-B48F-1D18A9856A87","first_name":"Lena","last_name":"Marr"},{"full_name":"Novarino, Gaia","last_name":"Novarino","first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178"},{"first_name":"Andre","last_name":"Marquand","full_name":"Marquand, Andre"},{"first_name":"Sarah Jane","last_name":"Böttger","full_name":"Böttger, Sarah Jane"},{"first_name":"Mira","last_name":"Tschorn","full_name":"Tschorn, Mira"},{"full_name":"Rapp, Michael","first_name":"Michael","last_name":"Rapp"},{"full_name":"Ask, Helga","first_name":"Helga","last_name":"Ask"},{"full_name":"Kjelkenes, Rikka","first_name":"Rikka","last_name":"Kjelkenes"},{"last_name":"Fernandez","first_name":"Sara","full_name":"Fernandez, Sara"},{"full_name":"Van Der Meer, Dennis","last_name":"Van Der Meer","first_name":"Dennis"},{"last_name":"Westlye","first_name":"Lars T.","full_name":"Westlye, Lars T."},{"full_name":"Andreassen, Ole A.","last_name":"Andreassen","first_name":"Ole A."},{"first_name":"Rieke","last_name":"Aden","full_name":"Aden, Rieke"},{"last_name":"Seefried","first_name":"Beke","full_name":"Seefried, Beke"},{"last_name":"Siehl","first_name":"Sebastian","full_name":"Siehl, Sebastian"},{"last_name":"Nees","first_name":"Frauke","full_name":"Nees, Frauke"},{"first_name":"Maja","last_name":"Neidhart","full_name":"Neidhart, Maja"},{"full_name":"Stringaris, Argyris","first_name":"Argyris","last_name":"Stringaris"},{"full_name":"Schwarz, Emanuel","last_name":"Schwarz","first_name":"Emanuel"},{"full_name":"Holz, Nathalie","last_name":"Holz","first_name":"Nathalie"},{"full_name":"Tost, Heike","first_name":"Heike","last_name":"Tost"},{"last_name":"Meyer-Lindenberg","first_name":"Andreas","full_name":"Meyer-Lindenberg, Andreas"},{"full_name":"Christmann, Nina","last_name":"Christmann","first_name":"Nina"},{"first_name":"Karina","last_name":"Jansone","full_name":"Jansone, Karina"},{"full_name":"Banaschewski, Tobias","first_name":"Tobias","last_name":"Banaschewski"},{"full_name":"Banks, Jamie","first_name":"Jamie","last_name":"Banks"},{"last_name":"Schepanski","first_name":"Kerstin","full_name":"Schepanski, Kerstin"},{"full_name":"Schütz, Tatjana","last_name":"Schütz","first_name":"Tatjana"},{"full_name":"Taron, Ulrike Helene","last_name":"Taron","first_name":"Ulrike Helene"},{"first_name":"Roland","last_name":"Eils","full_name":"Eils, Roland"},{"full_name":"Roy, Jean Charles","first_name":"Jean Charles","last_name":"Roy"},{"full_name":"Lett, Tristram A.","first_name":"Tristram A.","last_name":"Lett"},{"full_name":"Kebir, Hedi","last_name":"Kebir","first_name":"Hedi"},{"full_name":"Polemiti, Elli","last_name":"Polemiti","first_name":"Elli"},{"full_name":"Hitchen, Esther","first_name":"Esther","last_name":"Hitchen"},{"last_name":"Jentsch","first_name":"Marcel","full_name":"Jentsch, Marcel"},{"first_name":"Emin","last_name":"Serin","full_name":"Serin, Emin"},{"last_name":"Bernas","first_name":"Antoine","full_name":"Bernas, Antoine"},{"full_name":"Vaidya, Nilakshi","first_name":"Nilakshi","last_name":"Vaidya"},{"last_name":"Twardziok","first_name":"Sven","full_name":"Twardziok, Sven"},{"first_name":"Markus","last_name":"Ralser","full_name":"Ralser, Markus"},{"first_name":"Andreas","last_name":"Heinz","full_name":"Heinz, Andreas"},{"full_name":"Walter, Henrik","first_name":"Henrik","last_name":"Walter"}],"month":"10","article_number":"1128-1130","day":"01","year":"2024","date_created":"2025-08-10T22:01:30Z","volume":2,"_id":"20157","article_processing_charge":"No","language":[{"iso":"eng"}],"OA_type":"closed access","scopus_import":"1","doi":"10.1038/s44220-024-00320-3","intvolume":"         2","date_updated":"2025-08-11T06:53:55Z","status":"public","issue":"10","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"comment","type":"journal_article","oa_version":"None","department":[{"_id":"GaNo"}],"title":"Rethinking ethics in interdisciplinary and big data-driven neuroscience projects"},{"publication":"Cell","citation":{"ista":"Knaus L, Basilico B, Malzl D, Gerykova Bujalkova M, Smogavec M, Schwarz LA, Gorkiewicz S, Amberg N, Pauler F, Knittl-Frank C, Tassinari M, Maulide N, Rülicke T, Menche J, Hippenmeyer S, Novarino G. 2023. Large neutral amino acid levels tune perinatal neuronal excitability and survival. Cell. 186(9), 1950–1967.e25.","ama":"Knaus L, Basilico B, Malzl D, et al. Large neutral amino acid levels tune perinatal neuronal excitability and survival. <i>Cell</i>. 2023;186(9):1950-1967.e25. doi:<a href=\"https://doi.org/10.1016/j.cell.2023.02.037\">10.1016/j.cell.2023.02.037</a>","mla":"Knaus, Lisa, et al. “Large Neutral Amino Acid Levels Tune Perinatal Neuronal Excitability and Survival.” <i>Cell</i>, vol. 186, no. 9, Elsevier, 2023, p. 1950–1967.e25, doi:<a href=\"https://doi.org/10.1016/j.cell.2023.02.037\">10.1016/j.cell.2023.02.037</a>.","chicago":"Knaus, Lisa, Bernadette Basilico, Daniel Malzl, Maria Gerykova Bujalkova, Mateja Smogavec, Lena A. Schwarz, Sarah Gorkiewicz, et al. “Large Neutral Amino Acid Levels Tune Perinatal Neuronal Excitability and Survival.” <i>Cell</i>. Elsevier, 2023. <a href=\"https://doi.org/10.1016/j.cell.2023.02.037\">https://doi.org/10.1016/j.cell.2023.02.037</a>.","short":"L. Knaus, B. Basilico, D. Malzl, M. Gerykova Bujalkova, M. Smogavec, L.A. Schwarz, S. Gorkiewicz, N. Amberg, F. Pauler, C. Knittl-Frank, M. Tassinari, N. Maulide, T. Rülicke, J. Menche, S. Hippenmeyer, G. Novarino, Cell 186 (2023) 1950–1967.e25.","apa":"Knaus, L., Basilico, B., Malzl, D., Gerykova Bujalkova, M., Smogavec, M., Schwarz, L. A., … Novarino, G. (2023). Large neutral amino acid levels tune perinatal neuronal excitability and survival. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2023.02.037\">https://doi.org/10.1016/j.cell.2023.02.037</a>","ieee":"L. Knaus <i>et al.</i>, “Large neutral amino acid levels tune perinatal neuronal excitability and survival,” <i>Cell</i>, vol. 186, no. 9. Elsevier, p. 1950–1967.e25, 2023."},"abstract":[{"text":"Little is known about the critical metabolic changes that neural cells have to undergo during development and how temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically essential large neutral amino acids (LNAAs), lead to autism, we employed metabolomic profiling to study the metabolic states of the cerebral cortex across different developmental stages. We found that the forebrain undergoes significant metabolic remodeling throughout development, with certain groups of metabolites showing stage-specific changes, but what are the consequences of perturbing this metabolic program? By manipulating Slc7a5 expression in neural cells, we found that the metabolism of LNAAs and lipids are interconnected in the cortex. Deletion of Slc7a5 in neurons affects the postnatal metabolic state, leading to a shift in lipid metabolism. Additionally, it causes stage- and cell-type-specific alterations in neuronal activity patterns, resulting in a long-term circuit dysfunction.","lang":"eng"}],"corr_author":"1","has_accepted_license":"1","isi":1,"publisher":"Elsevier","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"file_date_updated":"2023-05-02T09:26:21Z","acknowledgement":"We thank A. Freeman and V. Voronin for technical assistance, S. Deixler, A. Stichelberger, M. Schunn, and the Preclinical Facility for managing our animal colony. We thank L. Andersen and J. Sonntag, who were involved in generating the MADM lines. We thank the ISTA LSF Mass Spectrometry Core Facility for assistance with the proteomic analysis, as well as the ISTA electron microscopy and Imaging and Optics facility for technical support. Metabolomics LC-MS/MS analysis was performed by the Metabolomics Facility at Vienna BioCenter Core Facilities (VBCF). We acknowledge the support of the EMBL Metabolomics Core Facility (MCF) for lipidomics and intracellular metabolomics mass spectrometry data acquisition and analysis. RNA sequencing was performed by the Next Generation Sequencing Facility at VBCF. Schematics were generated using Biorender.com. This work was supported by the Austrian Science Fund (FWF, DK W1232-B24) and by the European Union’s Horizon 2020 research and innovation program (ERC) grant 725780 (LinPro) to S.H. and 715508 (REVERSEAUTISM) to G.N.","external_id":{"pmid":["36996814"],"isi":["000991468700001"]},"date_published":"2023-04-27T00:00:00Z","publication_identifier":{"issn":["0092-8674"]},"pmid":1,"acknowledged_ssus":[{"_id":"PreCl"},{"_id":"EM-Fac"},{"_id":"Bio"},{"_id":"LifeSc"}],"date_created":"2023-04-05T08:15:40Z","day":"27","year":"2023","volume":186,"month":"04","quality_controlled":"1","related_material":{"link":[{"url":"https://ista.ac.at/en/news/feed-them-or-lose-them/","relation":"press_release","description":"News on ISTA Website"}],"record":[{"id":"19557","status":"public","relation":"dissertation_contains"},{"id":"13107","status":"public","relation":"dissertation_contains"}]},"author":[{"full_name":"Knaus, Lisa","id":"3B2ABCF4-F248-11E8-B48F-1D18A9856A87","last_name":"Knaus","first_name":"Lisa"},{"first_name":"Bernadette","last_name":"Basilico","orcid":"0000-0003-1843-3173","id":"36035796-5ACA-11E9-A75E-7AF2E5697425","full_name":"Basilico, Bernadette"},{"full_name":"Malzl, Daniel","last_name":"Malzl","first_name":"Daniel"},{"full_name":"Gerykova Bujalkova, Maria","first_name":"Maria","last_name":"Gerykova Bujalkova"},{"full_name":"Smogavec, Mateja","last_name":"Smogavec","first_name":"Mateja"},{"first_name":"Lena A.","last_name":"Schwarz","full_name":"Schwarz, Lena A."},{"id":"f141a35d-15a9-11ec-9fb2-fef6becc7b6f","last_name":"Gorkiewicz","first_name":"Sarah","full_name":"Gorkiewicz, Sarah"},{"id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3183-8207","last_name":"Amberg","first_name":"Nicole","full_name":"Amberg, Nicole"},{"first_name":"Florian","last_name":"Pauler","orcid":"0000-0002-7462-0048","id":"48EA0138-F248-11E8-B48F-1D18A9856A87","full_name":"Pauler, Florian"},{"full_name":"Knittl-Frank, Christian","last_name":"Knittl-Frank","first_name":"Christian"},{"full_name":"Tassinari, Marianna","last_name":"Tassinari","first_name":"Marianna","id":"7af593f1-d44a-11ed-bf94-a3646a6bb35e"},{"first_name":"Nuno","last_name":"Maulide","full_name":"Maulide, Nuno"},{"full_name":"Rülicke, Thomas","first_name":"Thomas","last_name":"Rülicke"},{"first_name":"Jörg","last_name":"Menche","full_name":"Menche, Jörg"},{"full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer","first_name":"Simon"},{"first_name":"Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia"}],"oa":1,"intvolume":"       186","scopus_import":"1","doi":"10.1016/j.cell.2023.02.037","status":"public","publication_status":"published","issue":"9","date_updated":"2026-04-14T08:34:36Z","language":[{"iso":"eng"}],"article_processing_charge":"Yes (via OA deal)","ddc":["570"],"file":[{"success":1,"content_type":"application/pdf","date_created":"2023-05-02T09:26:21Z","access_level":"open_access","date_updated":"2023-05-02T09:26:21Z","file_name":"2023_Cell_Knaus.pdf","checksum":"47e94fbe19e86505b429cb7a5b503ce6","file_size":15712841,"relation":"main_file","creator":"dernst","file_id":"12889"}],"_id":"12802","type":"journal_article","oa_version":"Published Version","keyword":["General Biochemistry","Genetics and Molecular Biology"],"article_type":"original","title":"Large neutral amino acid levels tune perinatal neuronal excitability and survival","department":[{"_id":"SiHi"},{"_id":"GaNo"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"1950-1967.e25","project":[{"_id":"2548AE96-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Molecular Drug Targets","grant_number":"W1232"},{"name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780","call_identifier":"H2020","_id":"260018B0-B435-11E9-9278-68D0E5697425"},{"_id":"25444568-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"715508","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models"}],"ec_funded":1},{"page":"1456-1467","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","type":"journal_article","oa_version":"Published Version","department":[{"_id":"GaNo"}],"title":"Effects of urban living environments on mental health in adults","ddc":["570"],"_id":"13168","file":[{"file_size":7365360,"relation":"main_file","creator":"dernst","file_id":"13171","success":1,"date_created":"2023-06-26T10:15:44Z","content_type":"application/pdf","date_updated":"2023-06-26T10:15:44Z","access_level":"open_access","checksum":"bcd3225b2731c3442fa98987fd3bd46d","file_name":"2023_NatureMedicine_Xu.pdf"}],"language":[{"iso":"eng"}],"article_processing_charge":"No","doi":"10.1038/s41591-023-02365-w","scopus_import":"1","intvolume":"        29","date_updated":"2023-12-13T11:25:55Z","status":"public","publication_status":"published","quality_controlled":"1","author":[{"full_name":"Xu, Jiayuan","first_name":"Jiayuan","last_name":"Xu"},{"first_name":"Nana","last_name":"Liu","full_name":"Liu, Nana"},{"last_name":"Polemiti","first_name":"Elli","full_name":"Polemiti, Elli"},{"full_name":"Garcia-Mondragon, Liliana","last_name":"Garcia-Mondragon","first_name":"Liliana"},{"first_name":"Jie","last_name":"Tang","full_name":"Tang, Jie"},{"first_name":"Xiaoxuan","last_name":"Liu","full_name":"Liu, Xiaoxuan"},{"last_name":"Lett","first_name":"Tristram","full_name":"Lett, Tristram"},{"first_name":"Le","last_name":"Yu","full_name":"Yu, Le"},{"last_name":"Nöthen","first_name":"Markus M.","full_name":"Nöthen, Markus M."},{"last_name":"Feng","first_name":"Jianfeng","full_name":"Feng, Jianfeng"},{"last_name":"Yu","first_name":"Chunshui","full_name":"Yu, Chunshui"},{"last_name":"Marquand","first_name":"Andre","full_name":"Marquand, Andre"},{"last_name":"Schumann","first_name":"Gunter","full_name":"Schumann, Gunter"},{"full_name":"Walter, Henrik","first_name":"Henrik","last_name":"Walter"},{"full_name":"Heinz, Andreas","last_name":"Heinz","first_name":"Andreas"},{"first_name":"Markus","last_name":"Ralser","full_name":"Ralser, Markus"},{"full_name":"Twardziok, Sven","last_name":"Twardziok","first_name":"Sven"},{"full_name":"Vaidya, Nilakshi","first_name":"Nilakshi","last_name":"Vaidya"},{"full_name":"Serin, Emin","first_name":"Emin","last_name":"Serin"},{"first_name":"Marcel","last_name":"Jentsch","full_name":"Jentsch, Marcel"},{"full_name":"Hitchen, Esther","first_name":"Esther","last_name":"Hitchen"},{"full_name":"Eils, Roland","first_name":"Roland","last_name":"Eils"},{"last_name":"Taron","first_name":"Ulrike Helene","full_name":"Taron, Ulrike Helene"},{"last_name":"Schütz","first_name":"Tatjana","full_name":"Schütz, Tatjana"},{"first_name":"Kerstin","last_name":"Schepanski","full_name":"Schepanski, Kerstin"},{"full_name":"Banks, Jamie","last_name":"Banks","first_name":"Jamie"},{"first_name":"Tobias","last_name":"Banaschewski","full_name":"Banaschewski, Tobias"},{"last_name":"Jansone","first_name":"Karina","full_name":"Jansone, Karina"},{"first_name":"Nina","last_name":"Christmann","full_name":"Christmann, Nina"},{"full_name":"Meyer-Lindenberg, Andreas","first_name":"Andreas","last_name":"Meyer-Lindenberg"},{"last_name":"Tost","first_name":"Heike","full_name":"Tost, Heike"},{"full_name":"Holz, Nathalie","first_name":"Nathalie","last_name":"Holz"},{"full_name":"Schwarz, Emanuel","last_name":"Schwarz","first_name":"Emanuel"},{"full_name":"Stringaris, Argyris","last_name":"Stringaris","first_name":"Argyris"},{"full_name":"Neidhart, Maja","last_name":"Neidhart","first_name":"Maja"},{"last_name":"Nees","first_name":"Frauke","full_name":"Nees, Frauke"},{"full_name":"Siehl, Sebastian","last_name":"Siehl","first_name":"Sebastian"},{"full_name":"A. Andreassen, Ole","first_name":"Ole","last_name":"A. Andreassen"},{"full_name":"T. Westlye, Lars","last_name":"T. Westlye","first_name":"Lars"},{"last_name":"Van Der Meer","first_name":"Dennis","full_name":"Van Der Meer, Dennis"},{"last_name":"Fernandez","first_name":"Sara","full_name":"Fernandez, Sara"},{"full_name":"Kjelkenes, Rikka","first_name":"Rikka","last_name":"Kjelkenes"},{"full_name":"Ask, Helga","first_name":"Helga","last_name":"Ask"},{"first_name":"Michael","last_name":"Rapp","full_name":"Rapp, Michael"},{"last_name":"Tschorn","first_name":"Mira","full_name":"Tschorn, Mira"},{"last_name":"Böttger","first_name":"Sarah Jane","full_name":"Böttger, Sarah Jane"},{"first_name":"Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia"},{"full_name":"Marr, Lena","first_name":"Lena","last_name":"Marr","id":"4406F586-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Slater, Mel","last_name":"Slater","first_name":"Mel"},{"first_name":"Guillem Feixas","last_name":"Viapiana","full_name":"Viapiana, Guillem Feixas"},{"full_name":"Orosa, Francisco Eiroa","last_name":"Orosa","first_name":"Francisco Eiroa"},{"first_name":"Jaime","last_name":"Gallego","full_name":"Gallego, Jaime"},{"full_name":"Pastor, Alvaro","last_name":"Pastor","first_name":"Alvaro"},{"full_name":"Forstner, Andreas","last_name":"Forstner","first_name":"Andreas"},{"first_name":"Per","last_name":"Hoffmann","full_name":"Hoffmann, Per"},{"full_name":"M. Nöthen, Markus","first_name":"Markus","last_name":"M. Nöthen"},{"full_name":"J. Forstner, Andreas","first_name":"Andreas","last_name":"J. Forstner"},{"full_name":"Claus, Isabelle","first_name":"Isabelle","last_name":"Claus"},{"full_name":"Miller, Abbi","last_name":"Miller","first_name":"Abbi"},{"full_name":"Heilmann-Heimbach, Stefanie","first_name":"Stefanie","last_name":"Heilmann-Heimbach"},{"full_name":"Sommer, Peter","first_name":"Peter","last_name":"Sommer"},{"last_name":"Boye","first_name":"Mona","full_name":"Boye, Mona"},{"last_name":"Wilbertz","first_name":"Johannes","full_name":"Wilbertz, Johannes"},{"full_name":"Schmitt, Karen","first_name":"Karen","last_name":"Schmitt"},{"last_name":"Jirsa","first_name":"Viktor","full_name":"Jirsa, Viktor"},{"first_name":"Spase","last_name":"Petkoski","full_name":"Petkoski, Spase"},{"first_name":"Séverine","last_name":"Pitel","full_name":"Pitel, Séverine"},{"last_name":"Otten","first_name":"Lisa","full_name":"Otten, Lisa"},{"full_name":"Athanasiadis, Anastasios Polykarpos","last_name":"Athanasiadis","first_name":"Anastasios Polykarpos"},{"first_name":"Charlie","last_name":"Pearmund","full_name":"Pearmund, Charlie"},{"full_name":"Spanlang, Bernhard","first_name":"Bernhard","last_name":"Spanlang"},{"full_name":"Alvarez, Elena","last_name":"Alvarez","first_name":"Elena"},{"full_name":"Sanchez, Mavi","last_name":"Sanchez","first_name":"Mavi"},{"last_name":"Giner","first_name":"Arantxa","full_name":"Giner, Arantxa"},{"full_name":"Hese, Sören","first_name":"Sören","last_name":"Hese"},{"first_name":"Paul","last_name":"Renner","full_name":"Renner, Paul"},{"full_name":"Jia, Tianye","last_name":"Jia","first_name":"Tianye"},{"first_name":"Yanting","last_name":"Gong","full_name":"Gong, Yanting"},{"full_name":"Xia, Yunman","last_name":"Xia","first_name":"Yunman"},{"first_name":"Xiao","last_name":"Chang","full_name":"Chang, Xiao"},{"first_name":"Vince","last_name":"Calhoun","full_name":"Calhoun, Vince"},{"full_name":"Liu, Jingyu","first_name":"Jingyu","last_name":"Liu"},{"last_name":"Thompson","first_name":"Paul","full_name":"Thompson, Paul"},{"full_name":"Clinton, Nicholas","first_name":"Nicholas","last_name":"Clinton"},{"first_name":"Sylvane","last_name":"Desrivieres","full_name":"Desrivieres, Sylvane"},{"last_name":"H. Young","first_name":"Allan","full_name":"H. Young, Allan"},{"full_name":"Stahl, Bernd","last_name":"Stahl","first_name":"Bernd"},{"first_name":"George","last_name":"Ogoh","full_name":"Ogoh, George"}],"month":"06","oa":1,"day":"15","year":"2023","date_created":"2023-06-25T22:00:46Z","volume":29,"publisher":"Springer Nature","isi":1,"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"has_accepted_license":"1","date_published":"2023-06-15T00:00:00Z","acknowledgement":"This work received support from the European Union-funded Horizon Europe project ‘environMENTAL’ (no. 101057429 to G.S., A.M. and M.M.N.) and cofunding by UK Research and Innovation under the UK Government’s Horizon Europe funding guarantee (nos. 10041392 and 10038599) for study design and data analysis; the Horizon 2020-funded European Research Council Advanced Grant ‘STRATIFY’ (no. 695313 to G.S. for study design and data analysis); the Human Brain Project (HBP SGA3, no. 945539 to G.S. for study design and data analysis); the National Institutes of Health (grant no. R01DA049238 to G.S. for study design and data analysis); the German Research Foundation (COPE; grant no. 675346 to G.S. for study design and data analysis); the National Natural Science Foundation of China (grant no. 82001797 to J.X., grant no. 82030053 to C.Y., grant no. 82202093 to J.T. and grant no. 82150710554 to G.S. for study design, data analysis and preparation of the manuscript); National Key Research and Development Program of China (grant no. 2018YFC1314301 to C.Y. for study design and data analysis); Tianjin Applied Basic Research Diversified Investment Foundation (grant no. 21JCYBJC01360 to J.X. for study design and data analysis); Tianjin Health Technology Project (grant no. TJWJ2021QN002 to J.X. for preparation of the manuscript); Science & Technology Development Fund of the Tianjin Education Commission for Higher Education (grant no. 2019KJ195 to J.X. for preparation of the manuscript); the Tianjin Medical University ‘Clinical Talent Training 123 Climbing Plan’ to J.X. for the preparation of the manuscript; Tianjin Key Medical Discipline (Specialty) Construction Project (grant no. TJYXZDXK-001A to C.Y. for preparation of the manuscript); the National Key R&D Program of China (grant no. 2022YFE0209400 to L.Y. for study design and data analysis); the Tsinghua University Initiative Scientific Research Program (grant no. 2021Z11GHX002 to L.Y. for study design and data analysis); the National Key Scientific and Technological Infrastructure Project ‘Earth System Science Numerical Simulator Facility’ (EarthLab to L.Y. for study design and data analysis); the Chinese National High-end Foreign Expert Recruitment Plan to G.S.; and the Alexander von Humboldt Foundation to G.S. for study design and data analysis.","external_id":{"isi":["001013172700001"]},"file_date_updated":"2023-06-26T10:15:44Z","publication_identifier":{"eissn":["1546-170X"],"issn":["1078-8956"]},"publication":"Nature Medicine","abstract":[{"text":"Urban-living individuals are exposed to many environmental factors that may combine and interact to influence mental health. While individual factors of an urban environment have been investigated in isolation, no attempt has been made to model how complex, real-life exposure to living in the city relates to brain and mental health, and how this is moderated by genetic factors. Using the data of 156,075 participants from the UK Biobank, we carried out sparse canonical correlation analyses to investigate the relationships between urban environments and psychiatric symptoms. We found an environmental profile of social deprivation, air pollution, street network and urban land-use density that was positively correlated with an affective symptom group (r = 0.22, Pperm < 0.001), mediated by brain volume differences consistent with reward processing, and moderated by genes enriched for stress response, including CRHR1, explaining 2.01% of the variance in brain volume differences. Protective factors such as greenness and generous destination accessibility were negatively correlated with an anxiety symptom group (r = 0.10, Pperm < 0.001), mediated by brain regions necessary for emotion regulation and moderated by EXD3, explaining 1.65% of the variance. The third urban environmental profile was correlated with an emotional instability symptom group (r = 0.03, Pperm < 0.001). Our findings suggest that different environmental profiles of urban living may influence specific psychiatric symptom groups through distinct neurobiological pathways.","lang":"eng"}],"citation":{"mla":"Xu, Jiayuan, et al. “Effects of Urban Living Environments on Mental Health in Adults.” <i>Nature Medicine</i>, vol. 29, Springer Nature, 2023, pp. 1456–67, doi:<a href=\"https://doi.org/10.1038/s41591-023-02365-w\">10.1038/s41591-023-02365-w</a>.","ama":"Xu J, Liu N, Polemiti E, et al. Effects of urban living environments on mental health in adults. <i>Nature Medicine</i>. 2023;29:1456-1467. doi:<a href=\"https://doi.org/10.1038/s41591-023-02365-w\">10.1038/s41591-023-02365-w</a>","ista":"Xu J, Liu N, Polemiti E, Garcia-Mondragon L, Tang J, Liu X, Lett T, Yu L, Nöthen MM, Feng J, Yu C, Marquand A, Schumann G, Walter H, Heinz A, Ralser M, Twardziok S, Vaidya N, Serin E, Jentsch M, Hitchen E, Eils R, Taron UH, Schütz T, Schepanski K, Banks J, Banaschewski T, Jansone K, Christmann N, Meyer-Lindenberg A, Tost H, Holz N, Schwarz E, Stringaris A, Neidhart M, Nees F, Siehl S, A. Andreassen O, T. Westlye L, Van Der Meer D, Fernandez S, Kjelkenes R, Ask H, Rapp M, Tschorn M, Böttger SJ, Novarino G, Marr L, Slater M, Viapiana GF, Orosa FE, Gallego J, Pastor A, Forstner A, Hoffmann P, M. Nöthen M, J. Forstner A, Claus I, Miller A, Heilmann-Heimbach S, Sommer P, Boye M, Wilbertz J, Schmitt K, Jirsa V, Petkoski S, Pitel S, Otten L, Athanasiadis AP, Pearmund C, Spanlang B, Alvarez E, Sanchez M, Giner A, Hese S, Renner P, Jia T, Gong Y, Xia Y, Chang X, Calhoun V, Liu J, Thompson P, Clinton N, Desrivieres S, H. Young A, Stahl B, Ogoh G. 2023. Effects of urban living environments on mental health in adults. Nature Medicine. 29, 1456–1467.","ieee":"J. Xu <i>et al.</i>, “Effects of urban living environments on mental health in adults,” <i>Nature Medicine</i>, vol. 29. Springer Nature, pp. 1456–1467, 2023.","apa":"Xu, J., Liu, N., Polemiti, E., Garcia-Mondragon, L., Tang, J., Liu, X., … Ogoh, G. (2023). Effects of urban living environments on mental health in adults. <i>Nature Medicine</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41591-023-02365-w\">https://doi.org/10.1038/s41591-023-02365-w</a>","short":"J. Xu, N. Liu, E. Polemiti, L. Garcia-Mondragon, J. Tang, X. Liu, T. Lett, L. Yu, M.M. Nöthen, J. Feng, C. Yu, A. Marquand, G. Schumann, H. Walter, A. Heinz, M. Ralser, S. Twardziok, N. Vaidya, E. Serin, M. Jentsch, E. Hitchen, R. Eils, U.H. Taron, T. Schütz, K. Schepanski, J. Banks, T. Banaschewski, K. Jansone, N. Christmann, A. Meyer-Lindenberg, H. Tost, N. Holz, E. Schwarz, A. Stringaris, M. Neidhart, F. Nees, S. Siehl, O. A. Andreassen, L. T. Westlye, D. Van Der Meer, S. Fernandez, R. Kjelkenes, H. Ask, M. Rapp, M. Tschorn, S.J. Böttger, G. Novarino, L. Marr, M. Slater, G.F. Viapiana, F.E. Orosa, J. Gallego, A. Pastor, A. Forstner, P. Hoffmann, M. M. Nöthen, A. J. Forstner, I. Claus, A. Miller, S. Heilmann-Heimbach, P. Sommer, M. Boye, J. Wilbertz, K. Schmitt, V. Jirsa, S. Petkoski, S. Pitel, L. Otten, A.P. Athanasiadis, C. Pearmund, B. Spanlang, E. Alvarez, M. Sanchez, A. Giner, S. Hese, P. Renner, T. Jia, Y. Gong, Y. Xia, X. Chang, V. Calhoun, J. Liu, P. Thompson, N. Clinton, S. Desrivieres, A. H. Young, B. Stahl, G. Ogoh, Nature Medicine 29 (2023) 1456–1467.","chicago":"Xu, Jiayuan, Nana Liu, Elli Polemiti, Liliana Garcia-Mondragon, Jie Tang, Xiaoxuan Liu, Tristram Lett, et al. “Effects of Urban Living Environments on Mental Health in Adults.” <i>Nature Medicine</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41591-023-02365-w\">https://doi.org/10.1038/s41591-023-02365-w</a>."}},{"author":[{"first_name":"Gunter","last_name":"Schumann","full_name":"Schumann, Gunter"},{"first_name":"Ole A.","last_name":"Andreassen","full_name":"Andreassen, Ole A."},{"first_name":"Tobias","last_name":"Banaschewski","full_name":"Banaschewski, Tobias"},{"last_name":"Calhoun","first_name":"Vince D.","full_name":"Calhoun, Vince D."},{"full_name":"Clinton, Nicholas","last_name":"Clinton","first_name":"Nicholas"},{"full_name":"Desrivieres, Sylvane","last_name":"Desrivieres","first_name":"Sylvane"},{"full_name":"Brandlistuen, Ragnhild Eek","first_name":"Ragnhild Eek","last_name":"Brandlistuen"},{"full_name":"Feng, Jianfeng","last_name":"Feng","first_name":"Jianfeng"},{"first_name":"Soeren","last_name":"Hese","full_name":"Hese, Soeren"},{"last_name":"Hitchen","first_name":"Esther","full_name":"Hitchen, Esther"},{"full_name":"Hoffmann, Per","last_name":"Hoffmann","first_name":"Per"},{"last_name":"Jia","first_name":"Tianye","full_name":"Jia, Tianye"},{"first_name":"Viktor","last_name":"Jirsa","full_name":"Jirsa, Viktor"},{"full_name":"Marquand, Andre F.","last_name":"Marquand","first_name":"Andre F."},{"full_name":"Nees, Frauke","last_name":"Nees","first_name":"Frauke"},{"full_name":"Nöthen, Markus M.","last_name":"Nöthen","first_name":"Markus M."},{"full_name":"Novarino, Gaia","last_name":"Novarino","first_name":"Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Polemiti, Elli","last_name":"Polemiti","first_name":"Elli"},{"full_name":"Ralser, Markus","last_name":"Ralser","first_name":"Markus"},{"full_name":"Rapp, Michael","first_name":"Michael","last_name":"Rapp"},{"last_name":"Schepanski","first_name":"Kerstin","full_name":"Schepanski, Kerstin"},{"full_name":"Schikowski, Tamara","first_name":"Tamara","last_name":"Schikowski"},{"last_name":"Slater","first_name":"Mel","full_name":"Slater, Mel"},{"full_name":"Sommer, Peter","first_name":"Peter","last_name":"Sommer"},{"last_name":"Stahl","first_name":"Bernd Carsten","full_name":"Stahl, Bernd Carsten"},{"first_name":"Paul M.","last_name":"Thompson","full_name":"Thompson, Paul M."},{"last_name":"Twardziok","first_name":"Sven","full_name":"Twardziok, Sven"},{"last_name":"Van Der Meer","first_name":"Dennis","full_name":"Van Der Meer, Dennis"},{"full_name":"Walter, Henrik","first_name":"Henrik","last_name":"Walter"},{"full_name":"Westlye, Lars","last_name":"Westlye","first_name":"Lars"}],"quality_controlled":"1","month":"10","volume":80,"year":"2023","day":"01","date_created":"2023-10-22T22:01:14Z","pmid":1,"publication_identifier":{"eissn":["2168-6238"]},"external_id":{"isi":["001093447000016"],"pmid":["37610741"]},"date_published":"2023-10-01T00:00:00Z","publisher":"American Medical Association","isi":1,"abstract":[{"text":"Importance  Climate change, pollution, urbanization, socioeconomic inequality, and psychosocial effects of the COVID-19 pandemic have caused massive changes in environmental conditions that affect brain health during the life span, both on a population level as well as on the level of the individual. How these environmental factors influence the brain, behavior, and mental illness is not well known.\r\nObservations  A research strategy enabling population neuroscience to contribute to identify brain mechanisms underlying environment-related mental illness by leveraging innovative enrichment tools for data federation, geospatial observation, climate and pollution measures, digital health, and novel data integration techniques is described. This strategy can inform innovative treatments that target causal cognitive and molecular mechanisms of mental illness related to the environment. An example is presented of the environMENTAL Project that is leveraging federated cohort data of over 1.5 million European citizens and patients enriched with deep phenotyping data from large-scale behavioral neuroimaging cohorts to identify brain mechanisms related to environmental adversity underlying symptoms of depression, anxiety, stress, and substance misuse.\r\nConclusions and Relevance  This research will lead to the development of objective biomarkers and evidence-based interventions that will significantly improve outcomes of environment-related mental illness.","lang":"eng"}],"citation":{"ieee":"G. Schumann <i>et al.</i>, “Addressing global environmental challenges to mental health using population neuroscience: A review,” <i>JAMA Psychiatry</i>, vol. 80, no. 10. American Medical Association, pp. 1066–1074, 2023.","short":"G. Schumann, O.A. Andreassen, T. Banaschewski, V.D. Calhoun, N. Clinton, S. Desrivieres, R.E. Brandlistuen, J. Feng, S. Hese, E. Hitchen, P. Hoffmann, T. Jia, V. Jirsa, A.F. Marquand, F. Nees, M.M. Nöthen, G. Novarino, E. Polemiti, M. Ralser, M. Rapp, K. Schepanski, T. Schikowski, M. Slater, P. Sommer, B.C. Stahl, P.M. Thompson, S. Twardziok, D. Van Der Meer, H. Walter, L. Westlye, JAMA Psychiatry 80 (2023) 1066–1074.","chicago":"Schumann, Gunter, Ole A. Andreassen, Tobias Banaschewski, Vince D. Calhoun, Nicholas Clinton, Sylvane Desrivieres, Ragnhild Eek Brandlistuen, et al. “Addressing Global Environmental Challenges to Mental Health Using Population Neuroscience: A Review.” <i>JAMA Psychiatry</i>. American Medical Association, 2023. <a href=\"https://doi.org/10.1001/jamapsychiatry.2023.2996\">https://doi.org/10.1001/jamapsychiatry.2023.2996</a>.","apa":"Schumann, G., Andreassen, O. A., Banaschewski, T., Calhoun, V. D., Clinton, N., Desrivieres, S., … Westlye, L. (2023). Addressing global environmental challenges to mental health using population neuroscience: A review. <i>JAMA Psychiatry</i>. American Medical Association. <a href=\"https://doi.org/10.1001/jamapsychiatry.2023.2996\">https://doi.org/10.1001/jamapsychiatry.2023.2996</a>","ama":"Schumann G, Andreassen OA, Banaschewski T, et al. Addressing global environmental challenges to mental health using population neuroscience: A review. <i>JAMA Psychiatry</i>. 2023;80(10):1066-1074. doi:<a href=\"https://doi.org/10.1001/jamapsychiatry.2023.2996\">10.1001/jamapsychiatry.2023.2996</a>","mla":"Schumann, Gunter, et al. “Addressing Global Environmental Challenges to Mental Health Using Population Neuroscience: A Review.” <i>JAMA Psychiatry</i>, vol. 80, no. 10, American Medical Association, 2023, pp. 1066–74, doi:<a href=\"https://doi.org/10.1001/jamapsychiatry.2023.2996\">10.1001/jamapsychiatry.2023.2996</a>.","ista":"Schumann G, Andreassen OA, Banaschewski T, Calhoun VD, Clinton N, Desrivieres S, Brandlistuen RE, Feng J, Hese S, Hitchen E, Hoffmann P, Jia T, Jirsa V, Marquand AF, Nees F, Nöthen MM, Novarino G, Polemiti E, Ralser M, Rapp M, Schepanski K, Schikowski T, Slater M, Sommer P, Stahl BC, Thompson PM, Twardziok S, Van Der Meer D, Walter H, Westlye L. 2023. Addressing global environmental challenges to mental health using population neuroscience: A review. JAMA Psychiatry. 80(10), 1066–1074."},"publication":"JAMA Psychiatry","page":"1066-1074","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"GaNo"}],"title":"Addressing global environmental challenges to mental health using population neuroscience: A review","article_type":"review","oa_version":"None","type":"journal_article","_id":"14443","article_processing_charge":"No","language":[{"iso":"eng"}],"date_updated":"2025-09-09T13:11:20Z","issue":"10","publication_status":"published","status":"public","doi":"10.1001/jamapsychiatry.2023.2996","scopus_import":"1","intvolume":"        80"},{"date_updated":"2023-12-13T13:06:07Z","status":"public","publication_status":"published","scopus_import":"1","doi":"10.3389/fpsyt.2023.1287879","intvolume":"        14","ddc":["570"],"file":[{"success":1,"date_created":"2023-10-30T12:48:40Z","content_type":"application/pdf","date_updated":"2023-10-30T12:48:40Z","access_level":"open_access","checksum":"0a76373e9a4c0fc199f80380de257e86","file_name":"2023_FrontiersPsychiatry_Narzisi.pdf","relation":"main_file","file_size":147878,"creator":"dernst","file_id":"14468"}],"_id":"14455","language":[{"iso":"eng"}],"article_processing_charge":"Yes","department":[{"_id":"GaNo"}],"title":"Tempering expectations: Considerations on the current state of stem cells therapy for autism treatment","article_type":"letter_note","type":"journal_article","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ieee":"A. Narzisi, A. Halladay, G. Masi, G. Novarino, and C. Lord, “Tempering expectations: Considerations on the current state of stem cells therapy for autism treatment,” <i>Frontiers in Psychiatry</i>, vol. 14. Frontiers, 2023.","apa":"Narzisi, A., Halladay, A., Masi, G., Novarino, G., &#38; Lord, C. (2023). Tempering expectations: Considerations on the current state of stem cells therapy for autism treatment. <i>Frontiers in Psychiatry</i>. Frontiers. <a href=\"https://doi.org/10.3389/fpsyt.2023.1287879\">https://doi.org/10.3389/fpsyt.2023.1287879</a>","chicago":"Narzisi, Antonio, Alycia Halladay, Gabriele Masi, Gaia Novarino, and Catherine Lord. “Tempering Expectations: Considerations on the Current State of Stem Cells Therapy for Autism Treatment.” <i>Frontiers in Psychiatry</i>. Frontiers, 2023. <a href=\"https://doi.org/10.3389/fpsyt.2023.1287879\">https://doi.org/10.3389/fpsyt.2023.1287879</a>.","short":"A. Narzisi, A. Halladay, G. Masi, G. Novarino, C. Lord, Frontiers in Psychiatry 14 (2023).","mla":"Narzisi, Antonio, et al. “Tempering Expectations: Considerations on the Current State of Stem Cells Therapy for Autism Treatment.” <i>Frontiers in Psychiatry</i>, vol. 14, 1287879, Frontiers, 2023, doi:<a href=\"https://doi.org/10.3389/fpsyt.2023.1287879\">10.3389/fpsyt.2023.1287879</a>.","ama":"Narzisi A, Halladay A, Masi G, Novarino G, Lord C. Tempering expectations: Considerations on the current state of stem cells therapy for autism treatment. <i>Frontiers in Psychiatry</i>. 2023;14. doi:<a href=\"https://doi.org/10.3389/fpsyt.2023.1287879\">10.3389/fpsyt.2023.1287879</a>","ista":"Narzisi A, Halladay A, Masi G, Novarino G, Lord C. 2023. Tempering expectations: Considerations on the current state of stem cells therapy for autism treatment. Frontiers in Psychiatry. 14, 1287879."},"publication":"Frontiers in Psychiatry","pmid":1,"acknowledgement":"The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work has been partially supported by Italian Ministry of Health Grant RC2023 (and the 5 × 1,000 voluntary contributions). The authors thank the children and their families with whom they work daily.","external_id":{"isi":["001084841700001"],"pmid":["37854442"]},"date_published":"2023-10-03T00:00:00Z","file_date_updated":"2023-10-30T12:48:40Z","publication_identifier":{"eissn":["1664-0640"]},"isi":1,"publisher":"Frontiers","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"has_accepted_license":"1","volume":14,"article_number":"1287879","day":"03","year":"2023","date_created":"2023-10-29T23:01:16Z","oa":1,"quality_controlled":"1","author":[{"first_name":"Antonio","last_name":"Narzisi","full_name":"Narzisi, Antonio"},{"first_name":"Alycia","last_name":"Halladay","full_name":"Halladay, Alycia"},{"first_name":"Gabriele","last_name":"Masi","full_name":"Masi, Gabriele"},{"orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","first_name":"Gaia","full_name":"Novarino, Gaia"},{"last_name":"Lord","first_name":"Catherine","full_name":"Lord, Catherine"}],"month":"10"}]