---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20859'
abstract:
- lang: eng
  text: Effective immune responses rely on the efficient migration of leukocytes.
    Yet, how temperature regulates migration dynamics at the single-cell level has
    remained poorly understood. Using zebrafish embryos and mouse tissue explants,
    we found that temperature positively regulates leukocyte migration speed, exploration,
    and arrival frequencies to wounds and lymph vessels. Complementary 2D and 3D cultures
    revealed that this thermokinetic control of cell migration is conserved across
    immune cell types, independently of the 3D tissue environment. By applying precise
    (sub-)cellular temperature modulation, we identified a rapid and reversible thermo-response
    that depends on myosin II activity. Small physiological increases in temperature
    (1°C –2°C), as present during fever-like conditions, profoundly increased immune
    responses by accelerating arrival times at lymphatic vessels and tissue wounds.
    These findings identify myosin-II-dependent actomyosin contractility as a critical
    mechanical structure regulating single-cell thermo-adaptability, with physiological
    implications for tuning the speed of immune responses in vivo.
acknowledged_ssus:
- _id: NanoFab
acknowledgement: 'The authors would like to acknowledge the Super Resolution Light
  Microcopy and Nanoscopy (SLN) Facility of ICFO for their support with imaging experiments,
  Johann Osmond (Nanofabrication laboratory, ICFO) for the design and production of
  molds for generating confinement coverslip, Merche Rivas for cell culture of immune
  cells and further support from the CRG Core Facilities for Genomics and Advanced
  Light Microscopy. We would like to thank Michael Sixt for discussions on this work
  and the Quidant, Ruprecht, and Wieser lab members for critical reading of the manuscript.
  This research was supported by the Scientific Service Units (SSU) of IST-Austria
  through resources provided by the Nanofabrication Facility (NFF). C.A. acknowledges
  the funding from the European Union’s Horizon 2020 research and innovation programme
  under the Marie Skłodowska-Curie grant agreement no 847517 and V.V. from the ICFOstepstone
  – PhD Programme funded by the European Union’s Horizon 2020 research and innovation
  programme under the Marie Skłodowska-Curie grant agreement no 665884. S.W. acknowledges
  support through the Spanish Ministry of Economy and Competitiveness via MINECO’s
  Plan Nacional (BFU2017-86296-P). V.R. acknowledges funding from the European Union’s
  HORIZON-EIC-2021-PATHFINDEROPEN program under grant agreement no. 101046620 and
  European Union''s Horizon Europe program under the grant agreement no. 101072123.
  E.K. acknowledges funding by a fellowship of the Ministry of Innovation, Science
  and Research of North-Rhine-Westphalia (AZ: 421-8.03.03.02-137069) and the Deutsche
  Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence
  Strategy – EXC 2151 – 390873048 and by the TRA Life and Health (University of Bonn)
  as part of the Excellence Strategy of the federal and state governments.'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Iván
  full_name: Company-Garrido, Iván
  last_name: Company-Garrido
- first_name: Alberto
  full_name: Zurita Carpio, Alberto
  last_name: Zurita Carpio
- first_name: Mariona
  full_name: Colomer-Rosell, Mariona
  last_name: Colomer-Rosell
- first_name: Bernard
  full_name: Ciraulo, Bernard
  last_name: Ciraulo
- first_name: Ronja
  full_name: Molkenbur, Ronja
  last_name: Molkenbur
- first_name: Peter
  full_name: Lanzerstorfer, Peter
  last_name: Lanzerstorfer
- first_name: Fabio
  full_name: Pezzano, Fabio
  last_name: Pezzano
- first_name: Costanza
  full_name: Agazzi, Costanza
  last_name: Agazzi
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Saumey
  full_name: Jain, Saumey
  last_name: Jain
- first_name: Jeroen M.
  full_name: Jacques, Jeroen M.
  last_name: Jacques
- first_name: Valeria
  full_name: Venturini, Valeria
  last_name: Venturini
- first_name: Christian
  full_name: Knapp, Christian
  last_name: Knapp
- first_name: Yufei
  full_name: Xie, Yufei
  last_name: Xie
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Julian
  full_name: Weghuber, Julian
  last_name: Weghuber
- first_name: Marcel
  full_name: Schaaf, Marcel
  last_name: Schaaf
- first_name: Romain
  full_name: Quidant, Romain
  last_name: Quidant
- first_name: Eva
  full_name: Kiermaier, Eva
  id: 3EB04B78-F248-11E8-B48F-1D18A9856A87
  last_name: Kiermaier
  orcid: 0000-0001-6165-5738
- first_name: Jaime
  full_name: Ortega Arroyo, Jaime
  last_name: Ortega Arroyo
- first_name: Verena
  full_name: Ruprecht, Verena
  id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
  last_name: Ruprecht
  orcid: 0000-0003-4088-8633
- first_name: Stefan
  full_name: Wieser, Stefan
  id: 355AA5A0-F248-11E8-B48F-1D18A9856A87
  last_name: Wieser
  orcid: 0000-0002-2670-2217
citation:
  ama: Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, et al. Myosin II regulates
    cellular thermo-adaptability and the efficiency of immune responses. <i>Developmental
    Cell</i>. 2026;61(2):356-371.e12. doi:<a href="https://doi.org/10.1016/j.devcel.2025.10.006">10.1016/j.devcel.2025.10.006</a>
  apa: Company-Garrido, I., Zurita Carpio, A., Colomer-Rosell, M., Ciraulo, B., Molkenbur,
    R., Lanzerstorfer, P., … Wieser, S. (2026). Myosin II regulates cellular thermo-adaptability
    and the efficiency of immune responses. <i>Developmental Cell</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.devcel.2025.10.006">https://doi.org/10.1016/j.devcel.2025.10.006</a>
  chicago: Company-Garrido, Iván, Alberto Zurita Carpio, Mariona Colomer-Rosell, Bernard
    Ciraulo, Ronja Molkenbur, Peter Lanzerstorfer, Fabio Pezzano, et al. “Myosin II
    Regulates Cellular Thermo-Adaptability and the Efficiency of Immune Responses.”
    <i>Developmental Cell</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.devcel.2025.10.006">https://doi.org/10.1016/j.devcel.2025.10.006</a>.
  ieee: I. Company-Garrido <i>et al.</i>, “Myosin II regulates cellular thermo-adaptability
    and the efficiency of immune responses,” <i>Developmental Cell</i>, vol. 61, no.
    2. Elsevier, p. 356–371.e12, 2026.
  ista: Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, Ciraulo B, Molkenbur
    R, Lanzerstorfer P, Pezzano F, Agazzi C, Hauschild R, Jain S, Jacques JM, Venturini
    V, Knapp C, Xie Y, Merrin J, Weghuber J, Schaaf M, Quidant R, Kiermaier E, Ortega
    Arroyo J, Ruprecht V, Wieser S. 2026. Myosin II regulates cellular thermo-adaptability
    and the efficiency of immune responses. Developmental Cell. 61(2), 356–371.e12.
  mla: Company-Garrido, Iván, et al. “Myosin II Regulates Cellular Thermo-Adaptability
    and the Efficiency of Immune Responses.” <i>Developmental Cell</i>, vol. 61, no.
    2, Elsevier, 2026, p. 356–371.e12, doi:<a href="https://doi.org/10.1016/j.devcel.2025.10.006">10.1016/j.devcel.2025.10.006</a>.
  short: I. Company-Garrido, A. Zurita Carpio, M. Colomer-Rosell, B. Ciraulo, R. Molkenbur,
    P. Lanzerstorfer, F. Pezzano, C. Agazzi, R. Hauschild, S. Jain, J.M. Jacques,
    V. Venturini, C. Knapp, Y. Xie, J. Merrin, J. Weghuber, M. Schaaf, R. Quidant,
    E. Kiermaier, J. Ortega Arroyo, V. Ruprecht, S. Wieser, Developmental Cell 61
    (2026) 356–371.e12.
das_tickbox: '1'
dataavailabilitystatement: "This study did not generate new unique reagents. Data
  are available upon request.\r\n•The custom-made codes used in this study are available
  at: https://github.com/mcolomerr/cell_thermo https://github.com/Stefan1980sol/Lymph_entry_simu\r\n•
  Any additional information required to reanalyze the data reported in this paper
  is available from the lead contact upon request."
date_created: 2025-12-28T23:01:27Z
date_published: 2026-02-11T00:00:00Z
date_updated: 2026-07-23T06:27:15Z
day: '11'
ddc:
- '570'
department:
- _id: Bio
- _id: NanoFab
doi: 10.1016/j.devcel.2025.10.006
external_id:
  pmid:
  - '41192429'
file:
- access_level: open_access
  checksum: 52fd52d2d19a4514f8fcc1b40f420ca2
  content_type: application/pdf
  creator: dernst
  date_created: 2026-07-23T06:26:25Z
  date_updated: 2026-07-23T06:26:25Z
  file_id: '22388'
  file_name: 2026_DevelopmentalCell_CompanyGarrido.pdf
  file_size: 12342817
  relation: main_file
  success: 1
file_date_updated: 2026-07-23T06:26:25Z
has_accepted_license: '1'
intvolume: '        61'
issue: '2'
keyword:
- thermobiology
- cell migration
- thermo-adaptability of immune cells
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 356-371.e12
pmid: 1
publication: Developmental Cell
publication_identifier:
  eissn:
  - 1878-1551
  issn:
  - 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
researchdata_availability: upon request
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Myosin II regulates cellular thermo-adaptability and the efficiency of immune
  responses
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 61
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19663'
abstract:
- lang: eng
  text: The centrosome is a microtubule orchestrator, nucleating and anchoring microtubules
    that grow radially and exert forces on cargos. At the same time, mechanical stresses
    from the microenvironment and cellular shape changes compress and bend microtubules.
    Yet, centrosomes are membraneless organelles, raising the question of how centrosomes
    withstand mechanical forces. Here, we discover that centrosomes can deform and
    even fracture. We reveal that centrosomes experience deformations during navigational
    pathfinding within motile cells. Coherence of the centrosome is maintained by
    Dyrk3 and cNAP1, preventing fracturing by forces. While cells can compensate for
    the depletion of centriolar-based centrosomes, the fracturing of centrosomes impedes
    cellular function by generating coexisting microtubule organizing centers that
    compete during path navigation and thereby cause cellular entanglement in the
    microenvironment. Our findings show that cells actively maintain the integrity
    of the centrosome to withstand mechanical forces. These results suggest that centrosome
    stability preservation is fundamental, given that almost all cells in multicellular
    organisms experience forces.
acknowledgement: "We thank L. Pelkmans and D. Dormann for providing Dyrk3-EGFP plasmids;
  M. Heuzé for providing a RFP-Pericentrin plasmid; T. Balla for providing a PH-Akt-GFP
  plasmid; E. Snaar-Jagalska for providing a pLenti-V6.3 Ultra-Chili plasmid; T. Tang
  for providing CEP120 a plasmid; D. Trono for providing pMD2.G and psSPAX2 plasmids;
  M. Sixt for providing EB3-mCherry and EMTB-mCherry plasmids as well as 3T3 fibroblasts,
  Lifeact-GFP Hoxb8 cells, and LX293 cells; M. Duggan for RNA isolation from migrating
  DCs; M. Schuster from the Biomedical Sequencing Facility at CeMM; J. Schwarz for
  providing Jurkat T cells; M. Götz for initial transcriptome analysis; M. Götz and
  F. Merino for discussion and sharing reagents; F. Gärtner for discussions and support;
  M. Benjamin Braun for critical reading of the manuscript; and the Core Facility
  Bioimaging, the Core Facility Flow Cytometry, and the Animal Core Facility of the
  Biomedical Center (BMC) for excellent support.\r\nThis work was supported by Peter
  Hans Hofschneider Professorship of the Stiftung Experimentelle Biomedizin (J.R.);
  German Research Foundation grant “CRC914, project A12” (J.R); German Research Foundation
  grant “SPP2332, project 492014049” (J.R.); LMU Institutional Strategy LMU-Excellent
  within the framework of the German Excellence Initiative (J.R.); Medical & Clinician
  Scientist Program (MCSP) LMU Munich (J.K.); Deutsche Forschungsgemeinschaft (DFG;
  German Research Foundation) under Germany’s Excellence Strategy – EXC2151 – 390873048
  (D.B.); Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) Grossgeräteantrag
  457838313 and under Germany’s Excellence Strategy – EXC 2151 – 390873048 (E.K.);
  Ministry of Innovation, Science and Research of North-Rhine-Westphalia (fellowship
  AZ: 421-8.03.03.02-137069) (E.K.); TRA Life and Health (University of Bonn) as part
  of the Excellence Strategy of the federal and state governments (E.K.); and CZI
  grant DAF2020-225401 and grant (DOI https://doi.org/10.37921/120055ratwvi) from
  the Chan Zuckerberg Initiative DAF (R.H.)."
article_number: eadx4047
article_processing_charge: Yes
article_type: original
author:
- first_name: Madeleine T.
  full_name: Schmitt, Madeleine T.
  last_name: Schmitt
- first_name: Janina
  full_name: Kroll, Janina
  last_name: Kroll
- first_name: Mauricio J.A.
  full_name: Ruiz-Fernandez, Mauricio J.A.
  last_name: Ruiz-Fernandez
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Shaunak
  full_name: Ghosh, Shaunak
  last_name: Ghosh
- first_name: Petra
  full_name: Kameritsch, Petra
  last_name: Kameritsch
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Johanna
  full_name: Schmid, Johanna
  last_name: Schmid
- first_name: Kasia
  full_name: Stefanowski, Kasia
  last_name: Stefanowski
- first_name: Andreas W.
  full_name: Thomae, Andreas W.
  last_name: Thomae
- first_name: Jingyuan
  full_name: Cheng, Jingyuan
  last_name: Cheng
- first_name: Gamze Naz
  full_name: Öztan, Gamze Naz
  last_name: Öztan
- first_name: Peter
  full_name: Konopka, Peter
  last_name: Konopka
- first_name: Germán Camargo
  full_name: Ortega, Germán Camargo
  last_name: Ortega
- first_name: Thomas
  full_name: Penz, Thomas
  last_name: Penz
- first_name: Luisa
  full_name: Bach, Luisa
  last_name: Bach
- first_name: Dirk
  full_name: Baumjohann, Dirk
  last_name: Baumjohann
- first_name: Christoph
  full_name: Bock, Christoph
  last_name: Bock
- first_name: Tobias
  full_name: Straub, Tobias
  last_name: Straub
- first_name: Felix
  full_name: Meissner, Felix
  last_name: Meissner
- first_name: Eva
  full_name: Kiermaier, Eva
  id: 3EB04B78-F248-11E8-B48F-1D18A9856A87
  last_name: Kiermaier
  orcid: 0000-0001-6165-5738
- first_name: Jörg
  full_name: Renkawitz, Jörg
  id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
  last_name: Renkawitz
  orcid: 0000-0003-2856-3369
citation:
  ama: Schmitt MT, Kroll J, Ruiz-Fernandez MJA, et al. Protecting centrosomes from
    fracturing enables efficient cell navigation. <i>Science Advances</i>. 2025;11(17).
    doi:<a href="https://doi.org/10.1126/sciadv.adx4047">10.1126/sciadv.adx4047</a>
  apa: Schmitt, M. T., Kroll, J., Ruiz-Fernandez, M. J. A., Hauschild, R., Ghosh,
    S., Kameritsch, P., … Renkawitz, J. (2025). Protecting centrosomes from fracturing
    enables efficient cell navigation. <i>Science Advances</i>. AAAS. <a href="https://doi.org/10.1126/sciadv.adx4047">https://doi.org/10.1126/sciadv.adx4047</a>
  chicago: Schmitt, Madeleine T., Janina Kroll, Mauricio J.A. Ruiz-Fernandez, Robert
    Hauschild, Shaunak Ghosh, Petra Kameritsch, Jack Merrin, et al. “Protecting Centrosomes
    from Fracturing Enables Efficient Cell Navigation.” <i>Science Advances</i>. AAAS,
    2025. <a href="https://doi.org/10.1126/sciadv.adx4047">https://doi.org/10.1126/sciadv.adx4047</a>.
  ieee: M. T. Schmitt <i>et al.</i>, “Protecting centrosomes from fracturing enables
    efficient cell navigation,” <i>Science Advances</i>, vol. 11, no. 17. AAAS, 2025.
  ista: Schmitt MT, Kroll J, Ruiz-Fernandez MJA, Hauschild R, Ghosh S, Kameritsch
    P, Merrin J, Schmid J, Stefanowski K, Thomae AW, Cheng J, Öztan GN, Konopka P,
    Ortega GC, Penz T, Bach L, Baumjohann D, Bock C, Straub T, Meissner F, Kiermaier
    E, Renkawitz J. 2025. Protecting centrosomes from fracturing enables efficient
    cell navigation. Science Advances. 11(17), eadx4047.
  mla: Schmitt, Madeleine T., et al. “Protecting Centrosomes from Fracturing Enables
    Efficient Cell Navigation.” <i>Science Advances</i>, vol. 11, no. 17, eadx4047,
    AAAS, 2025, doi:<a href="https://doi.org/10.1126/sciadv.adx4047">10.1126/sciadv.adx4047</a>.
  short: M.T. Schmitt, J. Kroll, M.J.A. Ruiz-Fernandez, R. Hauschild, S. Ghosh, P.
    Kameritsch, J. Merrin, J. Schmid, K. Stefanowski, A.W. Thomae, J. Cheng, G.N.
    Öztan, P. Konopka, G.C. Ortega, T. Penz, L. Bach, D. Baumjohann, C. Bock, T. Straub,
    F. Meissner, E. Kiermaier, J. Renkawitz, Science Advances 11 (2025).
date_created: 2025-05-11T22:02:38Z
date_published: 2025-04-25T00:00:00Z
date_updated: 2025-09-30T12:26:21Z
day: '25'
ddc:
- '570'
department:
- _id: Bio
- _id: NanoFab
doi: 10.1126/sciadv.adx4047
external_id:
  isi:
  - '001476113400016'
  pmid:
  - '40279414'
file:
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  checksum: e8ba22922fa5b23ccfcce8865f57226c
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  creator: dernst
  date_created: 2025-05-12T07:46:10Z
  date_updated: 2025-05-12T07:46:10Z
  file_id: '19679'
  file_name: 2025_ScienceAdvance_Schmitt.pdf
  file_size: 2707050
  relation: main_file
  success: 1
file_date_updated: 2025-05-12T07:46:10Z
has_accepted_license: '1'
intvolume: '        11'
isi: 1
issue: '17'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
  grant_number: CZI01
  name: Tools for automation and feedback microscopy
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Protecting centrosomes from fracturing enables efficient cell navigation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 11
year: '2025'
...
---
_id: '7875'
abstract:
- lang: eng
  text: 'Cells navigating through complex tissues face a fundamental challenge: while
    multiple protrusions explore different paths, the cell needs to avoid entanglement.
    How a cell surveys and then corrects its own shape is poorly understood. Here,
    we demonstrate that spatially distinct microtubule dynamics regulate amoeboid
    cell migration by locally promoting the retraction of protrusions. In migrating
    dendritic cells, local microtubule depolymerization within protrusions remote
    from the microtubule organizing center triggers actomyosin contractility controlled
    by RhoA and its exchange factor Lfc. Depletion of Lfc leads to aberrant myosin
    localization, thereby causing two effects that rate-limit locomotion: (1) impaired
    cell edge coordination during path finding and (2) defective adhesion resolution.
    Compromised shape control is particularly hindering in geometrically complex microenvironments,
    where it leads to entanglement and ultimately fragmentation of the cell body.
    We thus demonstrate that microtubules can act as a proprioceptive device: they
    sense cell shape and control actomyosin retraction to sustain cellular coherence.'
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
- _id: PreCl
acknowledgement: "The authors thank the Scientific Service Units (Life Sciences, Bioimaging,
  Preclinical) of the Institute of Science and Technology Austria for excellent support.
  This work was funded by the European Research Council (ERC StG 281556 and CoG 724373),
  two grants from the Austrian\r\nScience Fund (FWF; P29911 and DK Nanocell W1250-B20
  to M. Sixt) and by the German Research Foundation (DFG SFB1032 project B09) to O.
  Thorn-Seshold and D. Trauner. J. Renkawitz was supported by ISTFELLOW funding from
  the People Program (Marie Curie Actions) of the European Union’s Seventh Framework
  Programme (FP7/2007-2013) under the Research Executive Agency grant agreement (291734)
  and a European Molecular Biology Organization long-term fellowship (ALTF 1396-2014)
  co-funded by the European Commission (LTFCOFUND2013, GA-2013-609409), E. Kiermaier
  by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s
  Excellence Strategy—EXC 2151—390873048, and H. Hacker by the American Lebanese Syrian
  Associated ¨Charities. K.-D. Fischer was supported by the Analysis, Imaging and
  Modelling of Neuronal and Inflammatory Processes graduate school funded by the Ministry
  of Economics, Science, and Digitisation of the State Saxony-Anhalt and by the European
  Funds for Social and Regional Development."
article_number: e201907154
article_processing_charge: No
article_type: original
author:
- first_name: Aglaja
  full_name: Kopf, Aglaja
  id: 31DAC7B6-F248-11E8-B48F-1D18A9856A87
  last_name: Kopf
  orcid: 0000-0002-2187-6656
- first_name: Jörg
  full_name: Renkawitz, Jörg
  id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
  last_name: Renkawitz
  orcid: 0000-0003-2856-3369
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Irute
  full_name: Girkontaite, Irute
  last_name: Girkontaite
- first_name: Kerry
  full_name: Tedford, Kerry
  last_name: Tedford
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Oliver
  full_name: Thorn-Seshold, Oliver
  last_name: Thorn-Seshold
- first_name: Dirk
  full_name: Trauner, Dirk
  id: E8F27F48-3EBA-11E9-92A1-B709E6697425
  last_name: Trauner
- first_name: Hans
  full_name: Häcker, Hans
  last_name: Häcker
- first_name: Klaus Dieter
  full_name: Fischer, Klaus Dieter
  last_name: Fischer
- first_name: Eva
  full_name: Kiermaier, Eva
  id: 3EB04B78-F248-11E8-B48F-1D18A9856A87
  last_name: Kiermaier
  orcid: 0000-0001-6165-5738
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Kopf A, Renkawitz J, Hauschild R, et al. Microtubules control cellular shape
    and coherence in amoeboid migrating cells. <i>The Journal of Cell Biology</i>.
    2020;219(6). doi:<a href="https://doi.org/10.1083/jcb.201907154">10.1083/jcb.201907154</a>
  apa: Kopf, A., Renkawitz, J., Hauschild, R., Girkontaite, I., Tedford, K., Merrin,
    J., … Sixt, M. K. (2020). Microtubules control cellular shape and coherence in
    amoeboid migrating cells. <i>The Journal of Cell Biology</i>. Rockefeller University
    Press. <a href="https://doi.org/10.1083/jcb.201907154">https://doi.org/10.1083/jcb.201907154</a>
  chicago: Kopf, Aglaja, Jörg Renkawitz, Robert Hauschild, Irute Girkontaite, Kerry
    Tedford, Jack Merrin, Oliver Thorn-Seshold, et al. “Microtubules Control Cellular
    Shape and Coherence in Amoeboid Migrating Cells.” <i>The Journal of Cell Biology</i>.
    Rockefeller University Press, 2020. <a href="https://doi.org/10.1083/jcb.201907154">https://doi.org/10.1083/jcb.201907154</a>.
  ieee: A. Kopf <i>et al.</i>, “Microtubules control cellular shape and coherence
    in amoeboid migrating cells,” <i>The Journal of Cell Biology</i>, vol. 219, no.
    6. Rockefeller University Press, 2020.
  ista: Kopf A, Renkawitz J, Hauschild R, Girkontaite I, Tedford K, Merrin J, Thorn-Seshold
    O, Trauner D, Häcker H, Fischer KD, Kiermaier E, Sixt MK. 2020. Microtubules control
    cellular shape and coherence in amoeboid migrating cells. The Journal of Cell
    Biology. 219(6), e201907154.
  mla: Kopf, Aglaja, et al. “Microtubules Control Cellular Shape and Coherence in
    Amoeboid Migrating Cells.” <i>The Journal of Cell Biology</i>, vol. 219, no. 6,
    e201907154, Rockefeller University Press, 2020, doi:<a href="https://doi.org/10.1083/jcb.201907154">10.1083/jcb.201907154</a>.
  short: A. Kopf, J. Renkawitz, R. Hauschild, I. Girkontaite, K. Tedford, J. Merrin,
    O. Thorn-Seshold, D. Trauner, H. Häcker, K.D. Fischer, E. Kiermaier, M.K. Sixt,
    The Journal of Cell Biology 219 (2020).
corr_author: '1'
date_created: 2020-05-24T22:00:56Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2025-04-14T13:10:03Z
day: '01'
ddc:
- '570'
department:
- _id: MiSi
- _id: Bio
- _id: NanoFab
doi: 10.1083/jcb.201907154
ec_funded: 1
external_id:
  isi:
  - '000538141100020'
  pmid:
  - '32379884'
file:
- access_level: open_access
  checksum: cb0b9c77842ae1214caade7b77e4d82d
  content_type: application/pdf
  creator: dernst
  date_created: 2020-11-24T13:25:13Z
  date_updated: 2020-11-24T13:25:13Z
  file_id: '8801'
  file_name: 2020_JCellBiol_Kopf.pdf
  file_size: 7536712
  relation: main_file
  success: 1
file_date_updated: 2020-11-24T13:25:13Z
has_accepted_license: '1'
intvolume: '       219'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281556'
  name: Cytoskeletal force generation and force transduction of migrating leukocytes
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '724373'
  name: Cellular Navigation Along Spatial Gradients
- _id: 26018E70-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29911
  name: Mechanical adaptation of lamellipodial actin
- _id: 252C3B08-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: W1250-B20
  name: Nano-Analytics of Cellular Systems
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
- _id: 25A48D24-B435-11E9-9278-68D0E5697425
  grant_number: ALTF 1396-2014
  name: Molecular and system level view of immune cell migration
publication: The Journal of Cell Biology
publication_identifier:
  eissn:
  - 1540-8140
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Microtubules control cellular shape and coherence in amoeboid migrating cells
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 219
year: '2020'
...
---
_id: '1599'
abstract:
- lang: eng
  text: "The addition of polysialic acid to N- and/or O-linked glycans, referred to
    as polysialylation, is a rare posttranslational modification that is mainly known
    to control the developmental plasticity of the nervous system. Here we show that
    CCR7, the central chemokine receptor controlling immune cell trafficking to secondary
    lymphatic organs, carries polysialic acid. This modification is essential for
    the recognition of the CCR7 ligand CCL21. As a consequence, dendritic cell trafficking
    is abrogated in polysialyltransferase-deficient mice, manifesting as disturbed
    lymph node homeostasis and unresponsiveness to inflammatory stimuli. Structure-function
    analysis of chemokine-receptor interactions reveals that CCL21 adopts an autoinhibited
    conformation, which is released upon interaction with polysialic acid. Thus, we
    describe a glycosylation-mediated immune cell trafficking disorder and its mechanistic
    basis.\r\n"
acknowledged_ssus:
- _id: SSU
acknowledgement: 'We thank S. Schüchner and E. Ogris for kindly providing the antibody
  to GFP, M. Helmbrecht and A. Huber for providing Nrp2−/− mice, the IST Scientific
  Support Facilities for excellent services, and J. Renkawitz and K. Vaahtomeri for
  critically reading the manuscript. '
article_processing_charge: No
article_type: original
author:
- first_name: Eva
  full_name: Kiermaier, Eva
  id: 3EB04B78-F248-11E8-B48F-1D18A9856A87
  last_name: Kiermaier
  orcid: 0000-0001-6165-5738
- first_name: Christine
  full_name: Moussion, Christine
  id: 3356F664-F248-11E8-B48F-1D18A9856A87
  last_name: Moussion
- first_name: Christopher
  full_name: Veldkamp, Christopher
  last_name: Veldkamp
- first_name: Rita
  full_name: Gerardy  Schahn, Rita
  last_name: Gerardy  Schahn
- first_name: Ingrid
  full_name: De Vries, Ingrid
  id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
  last_name: De Vries
- first_name: Larry
  full_name: Williams, Larry
  last_name: Williams
- first_name: Gary
  full_name: Chaffee, Gary
  last_name: Chaffee
- first_name: Andrew
  full_name: Phillips, Andrew
  last_name: Phillips
- first_name: Friedrich
  full_name: Freiberger, Friedrich
  last_name: Freiberger
- first_name: Richard
  full_name: Imre, Richard
  last_name: Imre
- first_name: Deni
  full_name: Taleski, Deni
  last_name: Taleski
- first_name: Richard
  full_name: Payne, Richard
  last_name: Payne
- first_name: Asolina
  full_name: Braun, Asolina
  last_name: Braun
- first_name: Reinhold
  full_name: Förster, Reinhold
  last_name: Förster
- first_name: Karl
  full_name: Mechtler, Karl
  last_name: Mechtler
- first_name: Martina
  full_name: Mühlenhoff, Martina
  last_name: Mühlenhoff
- first_name: Brian
  full_name: Volkman, Brian
  last_name: Volkman
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Kiermaier E, Moussion C, Veldkamp C, et al. Polysialylation controls dendritic
    cell trafficking by regulating chemokine recognition. <i>Science</i>. 2016;351(6269):186-190.
    doi:<a href="https://doi.org/10.1126/science.aad0512">10.1126/science.aad0512</a>
  apa: Kiermaier, E., Moussion, C., Veldkamp, C., Gerardy  Schahn, R., de Vries, I.,
    Williams, L., … Sixt, M. K. (2016). Polysialylation controls dendritic cell trafficking
    by regulating chemokine recognition. <i>Science</i>. American Association for
    the Advancement of Science. <a href="https://doi.org/10.1126/science.aad0512">https://doi.org/10.1126/science.aad0512</a>
  chicago: Kiermaier, Eva, Christine Moussion, Christopher Veldkamp, Rita Gerardy 
    Schahn, Ingrid de Vries, Larry Williams, Gary Chaffee, et al. “Polysialylation
    Controls Dendritic Cell Trafficking by Regulating Chemokine Recognition.” <i>Science</i>.
    American Association for the Advancement of Science, 2016. <a href="https://doi.org/10.1126/science.aad0512">https://doi.org/10.1126/science.aad0512</a>.
  ieee: E. Kiermaier <i>et al.</i>, “Polysialylation controls dendritic cell trafficking
    by regulating chemokine recognition,” <i>Science</i>, vol. 351, no. 6269. American
    Association for the Advancement of Science, pp. 186–190, 2016.
  ista: Kiermaier E, Moussion C, Veldkamp C, Gerardy  Schahn R, de Vries I, Williams
    L, Chaffee G, Phillips A, Freiberger F, Imre R, Taleski D, Payne R, Braun A, Förster
    R, Mechtler K, Mühlenhoff M, Volkman B, Sixt MK. 2016. Polysialylation controls
    dendritic cell trafficking by regulating chemokine recognition. Science. 351(6269),
    186–190.
  mla: Kiermaier, Eva, et al. “Polysialylation Controls Dendritic Cell Trafficking
    by Regulating Chemokine Recognition.” <i>Science</i>, vol. 351, no. 6269, American
    Association for the Advancement of Science, 2016, pp. 186–90, doi:<a href="https://doi.org/10.1126/science.aad0512">10.1126/science.aad0512</a>.
  short: E. Kiermaier, C. Moussion, C. Veldkamp, R. Gerardy  Schahn, I. de Vries,
    L. Williams, G. Chaffee, A. Phillips, F. Freiberger, R. Imre, D. Taleski, R. Payne,
    A. Braun, R. Förster, K. Mechtler, M. Mühlenhoff, B. Volkman, M.K. Sixt, Science
    351 (2016) 186–190.
corr_author: '1'
date_created: 2018-12-11T11:52:57Z
date_published: 2016-01-08T00:00:00Z
date_updated: 2025-09-18T11:01:30Z
day: '08'
department:
- _id: MiSi
doi: 10.1126/science.aad0512
ec_funded: 1
external_id:
  isi:
  - '000367806500045'
  pmid:
  - '26657283'
intvolume: '       351'
isi: 1
issue: '6269'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583642/
month: '01'
oa: 1
oa_version: Submitted Version
page: 186 - 190
pmid: 1
project:
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281556'
  name: Cytoskeletal force generation and force transduction of migrating leukocytes
- _id: 25A76F58-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '289720'
  name: Stromal Cell-immune Cell Interactions in Health and Disease
- _id: 25A8E5EA-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Y 564-B12
  name: Cytoskeletal force generation and force transduction of migrating leukocytes
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5570'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Polysialylation controls dendritic cell trafficking by regulating chemokine
  recognition
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 351
year: '2016'
...
---
_id: '1618'
abstract:
- lang: eng
  text: CCL19 and CCL21 are chemokines involved in the trafficking of immune cells,
    particularly within the lymphatic system, through activation of CCR7. Concurrent
    expression of PSGL-1 and CCR7 in naive T-cells enhances recruitment of these cells
    to secondary lymphoid organs by CCL19 and CCL21. Here the solution structure of
    CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping
    shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19
    and binding is competitive. Implications for the mechanism of PSGL-1's enhancement
    of resting T-cell recruitment are discussed.
article_processing_charge: No
author:
- first_name: Christopher
  full_name: Veldkamp, Christopher
  last_name: Veldkamp
- first_name: Eva
  full_name: Kiermaier, Eva
  id: 3EB04B78-F248-11E8-B48F-1D18A9856A87
  last_name: Kiermaier
  orcid: 0000-0001-6165-5738
- first_name: Skylar
  full_name: Gabel Eissens, Skylar
  last_name: Gabel Eissens
- first_name: Miranda
  full_name: Gillitzer, Miranda
  last_name: Gillitzer
- first_name: David
  full_name: Lippner, David
  last_name: Lippner
- first_name: Frank
  full_name: Disilvio, Frank
  last_name: Disilvio
- first_name: Casey
  full_name: Mueller, Casey
  last_name: Mueller
- first_name: Paeton
  full_name: Wantuch, Paeton
  last_name: Wantuch
- first_name: Gary
  full_name: Chaffee, Gary
  last_name: Chaffee
- first_name: Michael
  full_name: Famiglietti, Michael
  last_name: Famiglietti
- first_name: Danielle
  full_name: Zgoba, Danielle
  last_name: Zgoba
- first_name: Asha
  full_name: Bailey, Asha
  last_name: Bailey
- first_name: Yaya
  full_name: Bah, Yaya
  last_name: Bah
- first_name: Samantha
  full_name: Engebretson, Samantha
  last_name: Engebretson
- first_name: David
  full_name: Graupner, David
  last_name: Graupner
- first_name: Emily
  full_name: Lackner, Emily
  last_name: Lackner
- first_name: Vincent
  full_name: Larosa, Vincent
  last_name: Larosa
- first_name: Tysha
  full_name: Medeiros, Tysha
  last_name: Medeiros
- first_name: Michael
  full_name: Olson, Michael
  last_name: Olson
- first_name: Andrew
  full_name: Phillips, Andrew
  last_name: Phillips
- first_name: Harley
  full_name: Pyles, Harley
  last_name: Pyles
- first_name: Amanda
  full_name: Richard, Amanda
  last_name: Richard
- first_name: Scott
  full_name: Schoeller, Scott
  last_name: Schoeller
- first_name: Boris
  full_name: Touzeau, Boris
  last_name: Touzeau
- first_name: Larry
  full_name: Williams, Larry
  last_name: Williams
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Francis
  full_name: Peterson, Francis
  last_name: Peterson
citation:
  ama: Veldkamp C, Kiermaier E, Gabel Eissens S, et al. Solution structure of CCL19
    and identification of overlapping CCR7 and PSGL-1 binding sites. <i>Biochemistry</i>.
    2015;54(27):4163-4166. doi:<a href="https://doi.org/10.1021/acs.biochem.5b00560">10.1021/acs.biochem.5b00560</a>
  apa: Veldkamp, C., Kiermaier, E., Gabel Eissens, S., Gillitzer, M., Lippner, D.,
    Disilvio, F., … Peterson, F. (2015). Solution structure of CCL19 and identification
    of overlapping CCR7 and PSGL-1 binding sites. <i>Biochemistry</i>. American Chemical
    Society. <a href="https://doi.org/10.1021/acs.biochem.5b00560">https://doi.org/10.1021/acs.biochem.5b00560</a>
  chicago: Veldkamp, Christopher, Eva Kiermaier, Skylar Gabel Eissens, Miranda Gillitzer,
    David Lippner, Frank Disilvio, Casey Mueller, et al. “Solution Structure of CCL19
    and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.” <i>Biochemistry</i>.
    American Chemical Society, 2015. <a href="https://doi.org/10.1021/acs.biochem.5b00560">https://doi.org/10.1021/acs.biochem.5b00560</a>.
  ieee: C. Veldkamp <i>et al.</i>, “Solution structure of CCL19 and identification
    of overlapping CCR7 and PSGL-1 binding sites,” <i>Biochemistry</i>, vol. 54, no.
    27. American Chemical Society, pp. 4163–4166, 2015.
  ista: Veldkamp C, Kiermaier E, Gabel Eissens S, Gillitzer M, Lippner D, Disilvio
    F, Mueller C, Wantuch P, Chaffee G, Famiglietti M, Zgoba D, Bailey A, Bah Y, Engebretson
    S, Graupner D, Lackner E, Larosa V, Medeiros T, Olson M, Phillips A, Pyles H,
    Richard A, Schoeller S, Touzeau B, Williams L, Sixt MK, Peterson F. 2015. Solution
    structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites.
    Biochemistry. 54(27), 4163–4166.
  mla: Veldkamp, Christopher, et al. “Solution Structure of CCL19 and Identification
    of Overlapping CCR7 and PSGL-1 Binding Sites.” <i>Biochemistry</i>, vol. 54, no.
    27, American Chemical Society, 2015, pp. 4163–66, doi:<a href="https://doi.org/10.1021/acs.biochem.5b00560">10.1021/acs.biochem.5b00560</a>.
  short: C. Veldkamp, E. Kiermaier, S. Gabel Eissens, M. Gillitzer, D. Lippner, F.
    Disilvio, C. Mueller, P. Wantuch, G. Chaffee, M. Famiglietti, D. Zgoba, A. Bailey,
    Y. Bah, S. Engebretson, D. Graupner, E. Lackner, V. Larosa, T. Medeiros, M. Olson,
    A. Phillips, H. Pyles, A. Richard, S. Schoeller, B. Touzeau, L. Williams, M.K.
    Sixt, F. Peterson, Biochemistry 54 (2015) 4163–4166.
date_created: 2018-12-11T11:53:03Z
date_published: 2015-06-26T00:00:00Z
date_updated: 2025-09-23T10:47:25Z
day: '26'
department:
- _id: MiSi
doi: 10.1021/acs.biochem.5b00560
ec_funded: 1
external_id:
  isi:
  - '000358105100001'
  pmid:
  - '26115234'
intvolume: '        54'
isi: 1
issue: '27'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809050/
month: '06'
oa: 1
oa_version: Submitted Version
page: 4163 - 4166
pmid: 1
project:
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281556'
  name: Cytoskeletal force generation and force transduction of migrating leukocytes
publication: Biochemistry
publication_status: published
publisher: American Chemical Society
publist_id: '5548'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1
  binding sites
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 54
year: '2015'
...
---
_id: '1686'
article_processing_charge: No
author:
- first_name: Eva
  full_name: Kiermaier, Eva
  id: 3EB04B78-F248-11E8-B48F-1D18A9856A87
  last_name: Kiermaier
  orcid: 0000-0001-6165-5738
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: 'Kiermaier E, Sixt MK. Fragmented communication between immune cells: Neutrophils
    blaze a trail with migratory cues for T cells to follow to sites of infection.
    <i>Science</i>. 2015;349(6252):1055-1056. doi:<a href="https://doi.org/10.1126/science.aad0867">10.1126/science.aad0867</a>'
  apa: 'Kiermaier, E., &#38; Sixt, M. K. (2015). Fragmented communication between
    immune cells: Neutrophils blaze a trail with migratory cues for T cells to follow
    to sites of infection. <i>Science</i>. American Association for the Advancement
    of Science. <a href="https://doi.org/10.1126/science.aad0867">https://doi.org/10.1126/science.aad0867</a>'
  chicago: 'Kiermaier, Eva, and Michael K Sixt. “Fragmented Communication between
    Immune Cells: Neutrophils Blaze a Trail with Migratory Cues for T Cells to Follow
    to Sites of Infection.” <i>Science</i>. American Association for the Advancement
    of Science, 2015. <a href="https://doi.org/10.1126/science.aad0867">https://doi.org/10.1126/science.aad0867</a>.'
  ieee: 'E. Kiermaier and M. K. Sixt, “Fragmented communication between immune cells:
    Neutrophils blaze a trail with migratory cues for T cells to follow to sites of
    infection,” <i>Science</i>, vol. 349, no. 6252. American Association for the Advancement
    of Science, pp. 1055–1056, 2015.'
  ista: 'Kiermaier E, Sixt MK. 2015. Fragmented communication between immune cells:
    Neutrophils blaze a trail with migratory cues for T cells to follow to sites of
    infection. Science. 349(6252), 1055–1056.'
  mla: 'Kiermaier, Eva, and Michael K. Sixt. “Fragmented Communication between Immune
    Cells: Neutrophils Blaze a Trail with Migratory Cues for T Cells to Follow to
    Sites of Infection.” <i>Science</i>, vol. 349, no. 6252, American Association
    for the Advancement of Science, 2015, pp. 1055–56, doi:<a href="https://doi.org/10.1126/science.aad0867">10.1126/science.aad0867</a>.'
  short: E. Kiermaier, M.K. Sixt, Science 349 (2015) 1055–1056.
corr_author: '1'
date_created: 2018-12-11T11:53:28Z
date_published: 2015-09-04T00:00:00Z
date_updated: 2025-09-23T08:52:36Z
day: '04'
department:
- _id: MiSi
doi: 10.1126/science.aad0867
external_id:
  isi:
  - '000360628900020'
intvolume: '       349'
isi: 1
issue: '6252'
language:
- iso: eng
month: '09'
oa_version: None
page: 1055 - 1056
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5459'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Fragmented communication between immune cells: Neutrophils blaze a trail with
  migratory cues for T cells to follow to sites of infection'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 349
year: '2015'
...