[{"author":[{"last_name":"Neidhart","first_name":"Maja","full_name":"Neidhart, Maja"},{"first_name":"Rikka","last_name":"Kjelkenes","full_name":"Kjelkenes, Rikka"},{"last_name":"Jansone","first_name":"Karina","full_name":"Jansone, Karina"},{"last_name":"Rehák Bučková","first_name":"Barbora","full_name":"Rehák Bučková, Barbora"},{"last_name":"Holz","first_name":"Nathalie","full_name":"Holz, Nathalie"},{"last_name":"Nees","first_name":"Frauke","full_name":"Nees, Frauke"},{"first_name":"Henrik","last_name":"Walter","full_name":"Walter, Henrik"},{"first_name":"Gunter","last_name":"Schumann","full_name":"Schumann, Gunter"},{"first_name":"Michael A.","last_name":"Rapp","full_name":"Rapp, Michael A."},{"full_name":"Banaschewski, Tobias","first_name":"Tobias","last_name":"Banaschewski"},{"full_name":"Schwarz, Emanuel","last_name":"Schwarz","first_name":"Emanuel"},{"full_name":"Marquand, Andre","first_name":"Andre","last_name":"Marquand"},{"last_name":"Ogoh","first_name":"George","full_name":"Ogoh, George"},{"full_name":"Stahl, Bernd","first_name":"Bernd","last_name":"Stahl"},{"first_name":"Allan H.","last_name":"Young","full_name":"Young, Allan H."},{"last_name":"Desrivières","first_name":"Sylvane","full_name":"Desrivières, Sylvane"},{"full_name":"Clinton, Nicholas","first_name":"Nicholas","last_name":"Clinton"},{"full_name":"Thompson, Paul","last_name":"Thompson","first_name":"Paul"},{"first_name":"Ameli","last_name":"Schwalber","full_name":"Schwalber, Ameli"},{"first_name":"Jingyu","last_name":"Liu","full_name":"Liu, Jingyu"},{"first_name":"Vince","last_name":"Calhoun","full_name":"Calhoun, Vince"},{"full_name":"Chang, Xiao","first_name":"Xiao","last_name":"Chang"},{"full_name":"Xia, Yunman","last_name":"Xia","first_name":"Yunman"},{"first_name":"Yanting","last_name":"Gong","full_name":"Gong, Yanting"},{"last_name":"Jia","first_name":"Tianye","full_name":"Jia, Tianye"},{"last_name":"Renner","first_name":"Paul","full_name":"Renner, Paul"},{"full_name":"Hese, Sören","last_name":"Hese","first_name":"Sören"},{"full_name":"Giner, Arantxa","last_name":"Giner","first_name":"Arantxa"},{"full_name":"Sanchez, Mavi","first_name":"Mavi","last_name":"Sanchez"},{"full_name":"Alvarez, Elena","last_name":"Alvarez","first_name":"Elena"},{"first_name":"Bernhard","last_name":"Spanlang","full_name":"Spanlang, Bernhard"},{"first_name":"Charlie","last_name":"Pearmund","full_name":"Pearmund, Charlie"},{"first_name":"Anastasios Polykarpos","last_name":"Athanasiadis","full_name":"Athanasiadis, Anastasios Polykarpos"},{"last_name":"Otten","first_name":"Lisa","full_name":"Otten, Lisa"},{"first_name":"Séverine","last_name":"Pitel","full_name":"Pitel, Séverine"},{"full_name":"Petkoski, Spase","first_name":"Spase","last_name":"Petkoski"},{"last_name":"Jirsa","first_name":"Viktor","full_name":"Jirsa, Viktor"},{"last_name":"Schmitt","first_name":"Karen","full_name":"Schmitt, Karen"},{"full_name":"Wilbertz, Johannes","first_name":"Johannes","last_name":"Wilbertz"},{"last_name":"Patraskaki","first_name":"Myrto","full_name":"Patraskaki, Myrto"},{"full_name":"Sommer, Peter","first_name":"Peter","last_name":"Sommer"},{"last_name":"Heilmann-Heimbach","first_name":"Stefanie","full_name":"Heilmann-Heimbach, Stefanie"},{"last_name":"Mathey","first_name":"Carina M.","full_name":"Mathey, Carina M."},{"last_name":"Miller","first_name":"Abigail","full_name":"Miller, Abigail"},{"full_name":"Claus, Isabelle","last_name":"Claus","first_name":"Isabelle"},{"full_name":"Nöthen, Markus M.","last_name":"Nöthen","first_name":"Markus M."},{"last_name":"Hoffmann","first_name":"Per","full_name":"Hoffmann, Per"},{"full_name":"Forstner, Andreas J.","last_name":"Forstner","first_name":"Andreas J."},{"full_name":"Pastor, Alvaro","first_name":"Alvaro","last_name":"Pastor"},{"last_name":"Gallego","first_name":"Jaime","full_name":"Gallego, Jaime"},{"full_name":"Orosa, Francisco Eiroa","first_name":"Francisco Eiroa","last_name":"Orosa"},{"full_name":"Viapiana, Guillem Feixas","last_name":"Viapiana","first_name":"Guillem Feixas"},{"last_name":"Slater","first_name":"Mel","full_name":"Slater, Mel"},{"id":"4406F586-F248-11E8-B48F-1D18A9856A87","first_name":"Lena","last_name":"Marr","full_name":"Marr, Lena"},{"orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia","last_name":"Novarino"},{"full_name":"Böttger, Sarah Jane","last_name":"Böttger","first_name":"Sarah Jane"},{"full_name":"Tschorn, Mira","last_name":"Tschorn","first_name":"Mira"},{"full_name":"Rapp, Michael","last_name":"Rapp","first_name":"Michael"},{"first_name":"Helga","last_name":"Ask","full_name":"Ask, Helga"},{"first_name":"Sara","last_name":"Fernandez","full_name":"Fernandez, Sara"},{"first_name":"Dennis","last_name":"Van Der Meer","full_name":"Van Der Meer, Dennis"},{"full_name":"Westlye, Lars T.","last_name":"Westlye","first_name":"Lars T."},{"last_name":"Andreassen","first_name":"Ole A.","full_name":"Andreassen, Ole A."},{"first_name":"Rieke","last_name":"Aden","full_name":"Aden, Rieke"},{"last_name":"Seefried","first_name":"Beke","full_name":"Seefried, Beke"},{"full_name":"Siehl, Sebastian","last_name":"Siehl","first_name":"Sebastian"},{"first_name":"Frauke","last_name":"Nees","full_name":"Nees, Frauke"},{"first_name":"Argyris","last_name":"Stringaris","full_name":"Stringaris, Argyris"},{"last_name":"Tost","first_name":"Heike","full_name":"Tost, Heike"},{"first_name":"Andreas","last_name":"Meyer-Lindenberg","full_name":"Meyer-Lindenberg, Andreas"},{"full_name":"Christmann, Nina","last_name":"Christmann","first_name":"Nina"},{"full_name":"Banks, Jamie","last_name":"Banks","first_name":"Jamie"},{"first_name":"Kerstin","last_name":"Schepanski","full_name":"Schepanski, Kerstin"},{"full_name":"Schütz, Tatjana","first_name":"Tatjana","last_name":"Schütz"},{"first_name":"Ulrike Helene","last_name":"Taron","full_name":"Taron, Ulrike Helene"},{"full_name":"Eils, Roland","first_name":"Roland","last_name":"Eils"},{"first_name":"Jean Charles","last_name":"Roy","full_name":"Roy, Jean Charles"},{"last_name":"Lett","first_name":"Tristram A.","full_name":"Lett, Tristram A."},{"full_name":"Kebir, Hedi","first_name":"Hedi","last_name":"Kebir"},{"full_name":"Polemiti, Elli","first_name":"Elli","last_name":"Polemiti"},{"first_name":"Esther","last_name":"Hitchen","full_name":"Hitchen, Esther"},{"first_name":"Marcel","last_name":"Jentsch","full_name":"Jentsch, Marcel"},{"first_name":"Emin","last_name":"Serin","full_name":"Serin, Emin"},{"first_name":"Antoine","last_name":"Bernas","full_name":"Bernas, Antoine"},{"full_name":"Vaidya, Nilakshi","first_name":"Nilakshi","last_name":"Vaidya"},{"full_name":"Twardziok, Sven","first_name":"Sven","last_name":"Twardziok"},{"full_name":"Ralser, Markus","first_name":"Markus","last_name":"Ralser"},{"first_name":"Andreas","last_name":"Heinz","full_name":"Heinz, Andreas"}],"date_created":"2025-07-20T22:02:04Z","publication_identifier":{"eissn":["2731-6076"]},"date_updated":"2025-07-22T08:59:10Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":2,"OA_type":"closed access","abstract":[{"text":"This Comment presents a high-level protocol for data harmonization within large cohorts, in which it postulates four main steps including (1) expert review, (2) pre-statistical harmonization, (3) statistical harmonization, and (4) validation.","lang":"eng"}],"oa_version":"None","status":"public","language":[{"iso":"eng"}],"article_type":"comment","article_processing_charge":"No","intvolume":"         2","_id":"20039","year":"2024","date_published":"2024-10-01T00:00:00Z","title":"A protocol for data harmonization in large cohorts","scopus_import":"1","month":"10","type":"journal_article","publication_status":"published","quality_controlled":"1","department":[{"_id":"GaNo"}],"publisher":"Springer Nature","publication":"Nature Mental Health","page":"1134-1137","citation":{"apa":"Neidhart, M., Kjelkenes, R., Jansone, K., Rehák Bučková, B., Holz, N., Nees, F., … Heinz, A. (2024). A protocol for data harmonization in large cohorts. <i>Nature Mental Health</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s44220-024-00315-0\">https://doi.org/10.1038/s44220-024-00315-0</a>","ama":"Neidhart M, Kjelkenes R, Jansone K, et al. A protocol for data harmonization in large cohorts. <i>Nature Mental Health</i>. 2024;2(10):1134-1137. doi:<a href=\"https://doi.org/10.1038/s44220-024-00315-0\">10.1038/s44220-024-00315-0</a>","ista":"Neidhart M, Kjelkenes R, Jansone K, Rehák Bučková B, Holz N, Nees F, Walter H, Schumann G, Rapp MA, Banaschewski T, Schwarz E, Marquand A, Ogoh G, Stahl B, Young AH, Desrivières S, Clinton N, Thompson P, Schwalber A, Liu J, Calhoun V, Chang X, Xia Y, Gong Y, Jia T, Renner P, Hese S, Giner A, Sanchez M, Alvarez E, Spanlang B, Pearmund C, Athanasiadis AP, Otten L, Pitel S, Petkoski S, Jirsa V, Schmitt K, Wilbertz J, Patraskaki M, Sommer P, Heilmann-Heimbach S, Mathey CM, Miller A, Claus I, Nöthen MM, Hoffmann P, Forstner AJ, Pastor A, Gallego J, Orosa FE, Viapiana GF, Slater M, Marr L, Novarino G, Böttger SJ, Tschorn M, Rapp M, Ask H, Fernandez S, Van Der Meer D, Westlye LT, Andreassen OA, Aden R, Seefried B, Siehl S, Nees F, Stringaris A, Tost H, Meyer-Lindenberg A, Christmann N, Banks J, Schepanski K, Schütz T, Taron UH, Eils R, Roy JC, Lett TA, Kebir H, Polemiti E, Hitchen E, Jentsch M, Serin E, Bernas A, Vaidya N, Twardziok S, Ralser M, Heinz A. 2024. A protocol for data harmonization in large cohorts. Nature Mental Health. 2(10), 1134–1137.","chicago":"Neidhart, Maja, Rikka Kjelkenes, Karina Jansone, Barbora Rehák Bučková, Nathalie Holz, Frauke Nees, Henrik Walter, et al. “A Protocol for Data Harmonization in Large Cohorts.” <i>Nature Mental Health</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s44220-024-00315-0\">https://doi.org/10.1038/s44220-024-00315-0</a>.","mla":"Neidhart, Maja, et al. “A Protocol for Data Harmonization in Large Cohorts.” <i>Nature Mental Health</i>, vol. 2, no. 10, Springer Nature, 2024, pp. 1134–37, doi:<a href=\"https://doi.org/10.1038/s44220-024-00315-0\">10.1038/s44220-024-00315-0</a>.","ieee":"M. Neidhart <i>et al.</i>, “A protocol for data harmonization in large cohorts,” <i>Nature Mental Health</i>, vol. 2, no. 10. Springer Nature, pp. 1134–1137, 2024.","short":"M. Neidhart, R. Kjelkenes, K. Jansone, B. Rehák Bučková, N. Holz, F. Nees, H. Walter, G. Schumann, M.A. Rapp, T. Banaschewski, E. Schwarz, A. Marquand, G. Ogoh, B. Stahl, A.H. Young, S. Desrivières, N. Clinton, P. Thompson, A. Schwalber, J. Liu, V. Calhoun, X. Chang, Y. Xia, Y. Gong, T. Jia, P. Renner, S. Hese, A. Giner, M. Sanchez, E. Alvarez, B. Spanlang, C. Pearmund, A.P. Athanasiadis, L. Otten, S. Pitel, S. Petkoski, V. Jirsa, K. Schmitt, J. Wilbertz, M. Patraskaki, P. Sommer, S. Heilmann-Heimbach, C.M. Mathey, A. Miller, I. Claus, M.M. Nöthen, P. Hoffmann, A.J. Forstner, A. Pastor, J. Gallego, F.E. Orosa, G.F. Viapiana, M. Slater, L. Marr, G. Novarino, S.J. Böttger, M. Tschorn, M. Rapp, H. Ask, S. Fernandez, D. Van Der Meer, L.T. Westlye, O.A. Andreassen, R. Aden, B. Seefried, S. Siehl, F. Nees, A. Stringaris, H. Tost, A. Meyer-Lindenberg, N. Christmann, J. Banks, K. Schepanski, T. Schütz, U.H. Taron, R. Eils, J.C. Roy, T.A. Lett, H. Kebir, E. Polemiti, E. Hitchen, M. Jentsch, E. Serin, A. Bernas, N. Vaidya, S. Twardziok, M. Ralser, A. Heinz, Nature Mental Health 2 (2024) 1134–1137."},"day":"01","acknowledgement":"Funded by the European Union. Complementary funding was received by UK Research and Innovation (UKRI) under the UK government’s Horizon Europe funding guarantee (10041392 and 10038599). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union, the European Health and Digital Executive Agency (HADEA) or UKRI. The European Union, HADEA or UKRI cannot be held responsible for them. This work received support from the Chinese Ministry for Science and Technology (MOST), the Horizon 2020-funded European Research Council advanced grant ‘STRATIFY’ (695313); the German Research Foundation (COPE; 675346; NE 1383/15-1 and BA 2088/7-1 (CoviDrug)), the National Natural Science Foundation of China grant 82150710554, the Hector II foundation and the German Center for Mental Health (DZPG) (01EE2301A, 01EE2304A, 01EE2301D).","doi":"10.1038/s44220-024-00315-0","issue":"10"},{"publication":"Nature Mental Health","publisher":"Springer Nature","department":[{"_id":"GaNo"}],"quality_controlled":"1","publication_status":"published","type":"journal_article","issue":"10","doi":"10.1038/s44220-024-00317-y","acknowledgement":"This work was supported by the Horizon 2021 (grant 101057429) and UK Research and Innovation (grants 10038599 and 10041392)-funded project environMENTAL. Other funding included the Medical Research Council and Medical Research Foundation (MR/R00465X/, MRF-058-0004-RG-DESRI, ‘ESTRA’- Neurobiological underpinning of eating disorders: integrative biopsychosocial longitudinal analyses in adolescents; and MR/S020306/1, MRF-058-0009-RG-DESR-C0759 ‘ESTRA’-Establishing causal relationships between biopsychosocial predictors and correlates of eating disorders and their mediation by neural pathways), the EU-funded FP6 Integrated Project IMAGEN (reinforcement-related behavior in normal brain function and psychopathology; LSHM-CT- 2007-037286), the Horizon 2020-funded European Research Council advanced grant for STRATIFY (brain network-based stratification of reinforcement-related disorders; 695313) and the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. This paper represents independent research, partly funded by the NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. The authors thank C. Schmäl for proofreading the manuscript.","day":"01","citation":{"mla":"Desrivières, Sylvane, et al. “Multi-Omics Analyses of the EnvironMENTAL Project Provide Insights into Mental Health and Disease.” <i>Nature Mental Health</i>, vol. 2, no. 10, Springer Nature, 2024, pp. 1131–33, doi:<a href=\"https://doi.org/10.1038/s44220-024-00317-y\">10.1038/s44220-024-00317-y</a>.","chicago":"Desrivières, Sylvane, Abigail Miller, Carina M. Mathey, Xinyang Yu, Di Chen, Kofoworola Agunbiade, Stefanie Heilmann-Heimbach, et al. “Multi-Omics Analyses of the EnvironMENTAL Project Provide Insights into Mental Health and Disease.” <i>Nature Mental Health</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s44220-024-00317-y\">https://doi.org/10.1038/s44220-024-00317-y</a>.","ista":"Desrivières S, Miller A, Mathey CM, Yu X, Chen D, Agunbiade K, Heilmann-Heimbach S, Forstner AJ, Schumann G, Hoffmann P, Nöthen MM, Ogoh G, Stahl B, Young AH, Clinton N, Thompson P, Schwalber A, Liu J, Calhoun V, Chang X, Xia Y, Gong Y, Jia T, Renner P, Hese S, Giner A, Sanchez M, Alvarez E, Spanlang B, Pearmund C, Athanasiadis AP, Otten L, Pitel S, Petkoski S, Jirsa V, Schmitt K, Wilbertz J, Patraskaki M, Sommer P, Claus I, Pastor A, Gallego J, Orosa FE, Viapiana GF, Slater M, Marr L, Novarino G, Marquand A, Böttger SJ, Tschorn M, Rapp M, Ask H, Kjelkenes R, Fernandez S, Van Der Meer D, Westlye LT, Andreassen OA, Aden R, Seefried B, Siehl S, Nees F, Neidhart M, Stringaris A, Schwarz E, Holz N, Tost H, Meyer-Lindenberg A, Christmann N, Jansone K, Banaschewski T, Banks J, Schepanski K, Schütz T, Taron UH, Eils R, Roy JC, Lett TA, Kebir H, Polemiti E, Hitchen E, Jentsch M, Serin E, Bernas A, Vaidya N, Twardziok S, Ralser M, Heinz A, Walter H. 2024. Multi-omics analyses of the environMENTAL project provide insights into mental health and disease. Nature Mental Health. 2(10), 1131–1133.","ama":"Desrivières S, Miller A, Mathey CM, et al. Multi-omics analyses of the environMENTAL project provide insights into mental health and disease. <i>Nature Mental Health</i>. 2024;2(10):1131-1133. doi:<a href=\"https://doi.org/10.1038/s44220-024-00317-y\">10.1038/s44220-024-00317-y</a>","apa":"Desrivières, S., Miller, A., Mathey, C. M., Yu, X., Chen, D., Agunbiade, K., … Walter, H. (2024). Multi-omics analyses of the environMENTAL project provide insights into mental health and disease. <i>Nature Mental Health</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s44220-024-00317-y\">https://doi.org/10.1038/s44220-024-00317-y</a>","short":"S. Desrivières, A. Miller, C.M. Mathey, X. Yu, D. Chen, K. Agunbiade, S. Heilmann-Heimbach, A.J. Forstner, G. Schumann, P. Hoffmann, M.M. Nöthen, G. Ogoh, B. Stahl, A.H. Young, N. Clinton, P. Thompson, A. Schwalber, J. Liu, V. Calhoun, X. Chang, Y. Xia, Y. Gong, T. Jia, P. Renner, S. Hese, A. Giner, M. Sanchez, E. Alvarez, B. Spanlang, C. Pearmund, A.P. Athanasiadis, L. Otten, S. Pitel, S. Petkoski, V. Jirsa, K. Schmitt, J. Wilbertz, M. Patraskaki, P. Sommer, I. Claus, A. Pastor, J. Gallego, F.E. Orosa, G.F. Viapiana, M. Slater, L. Marr, G. Novarino, A. Marquand, S.J. Böttger, M. Tschorn, M. Rapp, H. Ask, R. Kjelkenes, S. Fernandez, D. Van Der Meer, L.T. Westlye, O.A. Andreassen, R. Aden, B. Seefried, S. Siehl, F. Nees, M. Neidhart, A. Stringaris, E. Schwarz, N. Holz, H. Tost, A. Meyer-Lindenberg, N. Christmann, K. Jansone, T. Banaschewski, J. Banks, K. Schepanski, T. Schütz, U.H. Taron, R. Eils, J.C. Roy, T.A. Lett, H. Kebir, E. Polemiti, E. Hitchen, M. Jentsch, E. Serin, A. Bernas, N. Vaidya, S. Twardziok, M. Ralser, A. Heinz, H. Walter, Nature Mental Health 2 (2024) 1131–1133.","ieee":"S. Desrivières <i>et al.</i>, “Multi-omics analyses of the environMENTAL project provide insights into mental health and disease,” <i>Nature Mental Health</i>, vol. 2, no. 10. Springer Nature, pp. 1131–1133, 2024."},"page":"1131-1133","oa_version":"None","abstract":[{"lang":"eng","text":"Integrative analyses that incorporate different levels of ‘-omics’ data represent a powerful tool for deciphering the biological mechanisms that underlie environmental influences on mental health and disease. This Comment highlights various aspects of such multi-omics approaches, using the example of the EU-funded environMENTAL project."}],"OA_type":"closed access","volume":2,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-08-11T06:44:03Z","publication_identifier":{"eissn":["2731-6076"]},"date_created":"2025-08-10T22:01:30Z","author":[{"full_name":"Desrivières, Sylvane","last_name":"Desrivières","first_name":"Sylvane"},{"full_name":"Miller, Abigail","last_name":"Miller","first_name":"Abigail"},{"last_name":"Mathey","first_name":"Carina M.","full_name":"Mathey, Carina M."},{"first_name":"Xinyang","last_name":"Yu","full_name":"Yu, Xinyang"},{"last_name":"Chen","first_name":"Di","full_name":"Chen, Di"},{"first_name":"Kofoworola","last_name":"Agunbiade","full_name":"Agunbiade, Kofoworola"},{"first_name":"Stefanie","last_name":"Heilmann-Heimbach","full_name":"Heilmann-Heimbach, Stefanie"},{"first_name":"Andreas J.","last_name":"Forstner","full_name":"Forstner, Andreas J."},{"full_name":"Schumann, Gunter","first_name":"Gunter","last_name":"Schumann"},{"full_name":"Hoffmann, Per","last_name":"Hoffmann","first_name":"Per"},{"first_name":"Markus M.","last_name":"Nöthen","full_name":"Nöthen, Markus M."},{"full_name":"Ogoh, George","last_name":"Ogoh","first_name":"George"},{"full_name":"Stahl, Bernd","first_name":"Bernd","last_name":"Stahl"},{"full_name":"Young, Allan H.","last_name":"Young","first_name":"Allan H."},{"full_name":"Clinton, Nicholas","last_name":"Clinton","first_name":"Nicholas"},{"first_name":"Paul","last_name":"Thompson","full_name":"Thompson, Paul"},{"full_name":"Schwalber, Ameli","first_name":"Ameli","last_name":"Schwalber"},{"full_name":"Liu, Jingyu","first_name":"Jingyu","last_name":"Liu"},{"full_name":"Calhoun, Vince","last_name":"Calhoun","first_name":"Vince"},{"full_name":"Chang, Xiao","first_name":"Xiao","last_name":"Chang"},{"full_name":"Xia, Yunman","first_name":"Yunman","last_name":"Xia"},{"first_name":"Yanting","last_name":"Gong","full_name":"Gong, Yanting"},{"last_name":"Jia","first_name":"Tianye","full_name":"Jia, Tianye"},{"first_name":"Paul","last_name":"Renner","full_name":"Renner, Paul"},{"last_name":"Hese","first_name":"Sören","full_name":"Hese, Sören"},{"full_name":"Giner, Arantxa","first_name":"Arantxa","last_name":"Giner"},{"last_name":"Sanchez","first_name":"Mavi","full_name":"Sanchez, Mavi"},{"last_name":"Alvarez","first_name":"Elena","full_name":"Alvarez, Elena"},{"first_name":"Bernhard","last_name":"Spanlang","full_name":"Spanlang, Bernhard"},{"first_name":"Charlie","last_name":"Pearmund","full_name":"Pearmund, Charlie"},{"first_name":"Anastasios Polykarpos","last_name":"Athanasiadis","full_name":"Athanasiadis, Anastasios Polykarpos"},{"last_name":"Otten","first_name":"Lisa","full_name":"Otten, Lisa"},{"full_name":"Pitel, Séverine","last_name":"Pitel","first_name":"Séverine"},{"full_name":"Petkoski, Spase","first_name":"Spase","last_name":"Petkoski"},{"last_name":"Jirsa","first_name":"Viktor","full_name":"Jirsa, Viktor"},{"last_name":"Schmitt","first_name":"Karen","full_name":"Schmitt, Karen"},{"full_name":"Wilbertz, Johannes","first_name":"Johannes","last_name":"Wilbertz"},{"full_name":"Patraskaki, Myrto","first_name":"Myrto","last_name":"Patraskaki"},{"last_name":"Sommer","first_name":"Peter","full_name":"Sommer, Peter"},{"full_name":"Claus, Isabelle","last_name":"Claus","first_name":"Isabelle"},{"full_name":"Pastor, Alvaro","last_name":"Pastor","first_name":"Alvaro"},{"first_name":"Jaime","last_name":"Gallego","full_name":"Gallego, Jaime"},{"first_name":"Francisco Eiroa","last_name":"Orosa","full_name":"Orosa, Francisco Eiroa"},{"full_name":"Viapiana, Guillem Feixas","last_name":"Viapiana","first_name":"Guillem Feixas"},{"full_name":"Slater, Mel","last_name":"Slater","first_name":"Mel"},{"full_name":"Marr, Lena","last_name":"Marr","first_name":"Lena","id":"4406F586-F248-11E8-B48F-1D18A9856A87"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","first_name":"Gaia","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178"},{"last_name":"Marquand","first_name":"Andre","full_name":"Marquand, Andre"},{"first_name":"Sarah Jane","last_name":"Böttger","full_name":"Böttger, Sarah Jane"},{"last_name":"Tschorn","first_name":"Mira","full_name":"Tschorn, Mira"},{"full_name":"Rapp, Michael","first_name":"Michael","last_name":"Rapp"},{"full_name":"Ask, Helga","last_name":"Ask","first_name":"Helga"},{"last_name":"Kjelkenes","first_name":"Rikka","full_name":"Kjelkenes, Rikka"},{"full_name":"Fernandez, Sara","last_name":"Fernandez","first_name":"Sara"},{"first_name":"Dennis","last_name":"Van Der Meer","full_name":"Van Der Meer, Dennis"},{"full_name":"Westlye, Lars T.","first_name":"Lars T.","last_name":"Westlye"},{"last_name":"Andreassen","first_name":"Ole A.","full_name":"Andreassen, Ole A."},{"full_name":"Aden, Rieke","last_name":"Aden","first_name":"Rieke"},{"full_name":"Seefried, Beke","last_name":"Seefried","first_name":"Beke"},{"full_name":"Siehl, Sebastian","first_name":"Sebastian","last_name":"Siehl"},{"full_name":"Nees, Frauke","last_name":"Nees","first_name":"Frauke"},{"first_name":"Maja","last_name":"Neidhart","full_name":"Neidhart, Maja"},{"last_name":"Stringaris","first_name":"Argyris","full_name":"Stringaris, Argyris"},{"last_name":"Schwarz","first_name":"Emanuel","full_name":"Schwarz, Emanuel"},{"first_name":"Nathalie","last_name":"Holz","full_name":"Holz, Nathalie"},{"full_name":"Tost, Heike","first_name":"Heike","last_name":"Tost"},{"first_name":"Andreas","last_name":"Meyer-Lindenberg","full_name":"Meyer-Lindenberg, Andreas"},{"first_name":"Nina","last_name":"Christmann","full_name":"Christmann, Nina"},{"last_name":"Jansone","first_name":"Karina","full_name":"Jansone, Karina"},{"first_name":"Tobias","last_name":"Banaschewski","full_name":"Banaschewski, Tobias"},{"first_name":"Jamie","last_name":"Banks","full_name":"Banks, Jamie"},{"full_name":"Schepanski, Kerstin","last_name":"Schepanski","first_name":"Kerstin"},{"full_name":"Schütz, Tatjana","first_name":"Tatjana","last_name":"Schütz"},{"full_name":"Taron, Ulrike Helene","last_name":"Taron","first_name":"Ulrike Helene"},{"first_name":"Roland","last_name":"Eils","full_name":"Eils, Roland"},{"first_name":"Jean Charles","last_name":"Roy","full_name":"Roy, Jean Charles"},{"full_name":"Lett, Tristram A.","last_name":"Lett","first_name":"Tristram A."},{"full_name":"Kebir, Hedi","last_name":"Kebir","first_name":"Hedi"},{"full_name":"Polemiti, Elli","first_name":"Elli","last_name":"Polemiti"},{"last_name":"Hitchen","first_name":"Esther","full_name":"Hitchen, Esther"},{"last_name":"Jentsch","first_name":"Marcel","full_name":"Jentsch, Marcel"},{"last_name":"Serin","first_name":"Emin","full_name":"Serin, Emin"},{"first_name":"Antoine","last_name":"Bernas","full_name":"Bernas, Antoine"},{"last_name":"Vaidya","first_name":"Nilakshi","full_name":"Vaidya, Nilakshi"},{"full_name":"Twardziok, Sven","first_name":"Sven","last_name":"Twardziok"},{"last_name":"Ralser","first_name":"Markus","full_name":"Ralser, Markus"},{"full_name":"Heinz, Andreas","first_name":"Andreas","last_name":"Heinz"},{"first_name":"Henrik","last_name":"Walter","full_name":"Walter, Henrik"}],"month":"10","scopus_import":"1","title":"Multi-omics analyses of the environMENTAL project provide insights into mental health and disease","date_published":"2024-10-01T00:00:00Z","year":"2024","_id":"20156","intvolume":"         2","article_processing_charge":"No","article_type":"comment","language":[{"iso":"eng"}],"status":"public"},{"publisher":"Springer Nature","publication":"Nature Mental Health","type":"journal_article","publication_status":"published","quality_controlled":"1","department":[{"_id":"GaNo"}],"citation":{"short":"B. Stahl, G. Ogoh, G. Schumann, H. Walter, B. Stahl, A.H. Young, S. Desrivières, N. Clinton, P. Thompson, A. Schwalber, J. Liu, V. Calhoun, X. Chang, Y. Xia, Y. Gong, T. Jia, P. Renner, S. Hese, A. Giner, M. Sanchez, E. Alvarez, B. Spanlang, C. Pearmund, A.P. Athanasiadis, L. Otten, S. Pitel, S. Petkoski, V. Jirsa, K. Schmitt, J. Wilbertz, M. Patraskaki, P. Sommer, S. Heilmann-Heimbach, C.M. Mathey, A. Miller, I. Claus, M.M. Nöthen, P. Hoffmann, A.J. Forstner, A. Pastor, J. Gallego, F.E. Orosa, G.F. Viapiana, M. Slater, L. Marr, G. Novarino, A. Marquand, S.J. Böttger, M. Tschorn, M. Rapp, H. Ask, R. Kjelkenes, S. Fernandez, D. Van Der Meer, L.T. Westlye, O.A. Andreassen, R. Aden, B. Seefried, S. Siehl, F. Nees, M. Neidhart, A. Stringaris, E. Schwarz, N. Holz, H. Tost, A. Meyer-Lindenberg, N. Christmann, K. Jansone, T. Banaschewski, J. Banks, K. Schepanski, T. Schütz, U.H. Taron, R. Eils, J.C. Roy, T.A. Lett, H. Kebir, E. Polemiti, E. Hitchen, M. Jentsch, E. Serin, A. Bernas, N. Vaidya, S. Twardziok, M. Ralser, A. Heinz, H. Walter, Nature Mental Health 2 (2024).","ieee":"B. Stahl <i>et al.</i>, “Rethinking ethics in interdisciplinary and big data-driven neuroscience projects,” <i>Nature Mental Health</i>, vol. 2, no. 10. Springer Nature, 2024.","chicago":"Stahl, Bernd, George Ogoh, Gunter Schumann, Henrik Walter, Bernd Stahl, Allan H. Young, Sylvane Desrivières, et al. “Rethinking Ethics in Interdisciplinary and Big Data-Driven Neuroscience Projects.” <i>Nature Mental Health</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s44220-024-00320-3\">https://doi.org/10.1038/s44220-024-00320-3</a>.","ista":"Stahl B, Ogoh G, Schumann G, Walter H, Stahl B, Young AH, Desrivières S, Clinton N, Thompson P, Schwalber A, Liu J, Calhoun V, Chang X, Xia Y, Gong Y, Jia T, Renner P, Hese S, Giner A, Sanchez M, Alvarez E, Spanlang B, Pearmund C, Athanasiadis AP, Otten L, Pitel S, Petkoski S, Jirsa V, Schmitt K, Wilbertz J, Patraskaki M, Sommer P, Heilmann-Heimbach S, Mathey CM, Miller A, Claus I, Nöthen MM, Hoffmann P, Forstner AJ, Pastor A, Gallego J, Orosa FE, Viapiana GF, Slater M, Marr L, Novarino G, Marquand A, Böttger SJ, Tschorn M, Rapp M, Ask H, Kjelkenes R, Fernandez S, Van Der Meer D, Westlye LT, Andreassen OA, Aden R, Seefried B, Siehl S, Nees F, Neidhart M, Stringaris A, Schwarz E, Holz N, Tost H, Meyer-Lindenberg A, Christmann N, Jansone K, Banaschewski T, Banks J, Schepanski K, Schütz T, Taron UH, Eils R, Roy JC, Lett TA, Kebir H, Polemiti E, Hitchen E, Jentsch M, Serin E, Bernas A, Vaidya N, Twardziok S, Ralser M, Heinz A, Walter H. 2024. Rethinking ethics in interdisciplinary and big data-driven neuroscience projects. Nature Mental Health. 2(10), 1128–1130.","apa":"Stahl, B., Ogoh, G., Schumann, G., Walter, H., Stahl, B., Young, A. H., … Walter, H. (2024). Rethinking ethics in interdisciplinary and big data-driven neuroscience projects. <i>Nature Mental Health</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s44220-024-00320-3\">https://doi.org/10.1038/s44220-024-00320-3</a>","ama":"Stahl B, Ogoh G, Schumann G, et al. Rethinking ethics in interdisciplinary and big data-driven neuroscience projects. <i>Nature Mental Health</i>. 2024;2(10). doi:<a href=\"https://doi.org/10.1038/s44220-024-00320-3\">10.1038/s44220-024-00320-3</a>","mla":"Stahl, Bernd, et al. “Rethinking Ethics in Interdisciplinary and Big Data-Driven Neuroscience Projects.” <i>Nature Mental Health</i>, vol. 2, no. 10, 1128–1130, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1038/s44220-024-00320-3\">10.1038/s44220-024-00320-3</a>."},"day":"01","article_number":"1128-1130","acknowledgement":"Funded provided by the European Union. Complementary funding was received by UK Research and Innovation (UKRI) under the UK government’s Horizon Europe funding guarantee (10131373and 10038599) and Ministry of Science and Technology of China (MOST) National Key Project of ‘Inter-governmental International Scientific and Technological Innovation Cooperation’ (2023YFE0199700).","doi":"10.1038/s44220-024-00320-3","issue":"10","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"closed access","volume":2,"abstract":[{"text":"The focus of much of contemporary research ethics is on compliance with established protocols. However, large data-driven neuroscience research raises new ethical concerns that have no agreed-upon solution. Here we reflect on these challenges and propose better integration of public and patient involvement in this evolving landscape.","lang":"eng"}],"oa_version":"None","author":[{"last_name":"Stahl","first_name":"Bernd","full_name":"Stahl, Bernd"},{"first_name":"George","last_name":"Ogoh","full_name":"Ogoh, George"},{"last_name":"Schumann","first_name":"Gunter","full_name":"Schumann, Gunter"},{"full_name":"Walter, Henrik","first_name":"Henrik","last_name":"Walter"},{"first_name":"Bernd","last_name":"Stahl","full_name":"Stahl, Bernd"},{"full_name":"Young, Allan H.","last_name":"Young","first_name":"Allan H."},{"full_name":"Desrivières, Sylvane","first_name":"Sylvane","last_name":"Desrivières"},{"first_name":"Nicholas","last_name":"Clinton","full_name":"Clinton, Nicholas"},{"full_name":"Thompson, Paul","first_name":"Paul","last_name":"Thompson"},{"full_name":"Schwalber, Ameli","first_name":"Ameli","last_name":"Schwalber"},{"first_name":"Jingyu","last_name":"Liu","full_name":"Liu, Jingyu"},{"first_name":"Vince","last_name":"Calhoun","full_name":"Calhoun, Vince"},{"last_name":"Chang","first_name":"Xiao","full_name":"Chang, Xiao"},{"full_name":"Xia, Yunman","last_name":"Xia","first_name":"Yunman"},{"last_name":"Gong","first_name":"Yanting","full_name":"Gong, Yanting"},{"first_name":"Tianye","last_name":"Jia","full_name":"Jia, Tianye"},{"last_name":"Renner","first_name":"Paul","full_name":"Renner, Paul"},{"full_name":"Hese, Sören","last_name":"Hese","first_name":"Sören"},{"first_name":"Arantxa","last_name":"Giner","full_name":"Giner, Arantxa"},{"last_name":"Sanchez","first_name":"Mavi","full_name":"Sanchez, Mavi"},{"first_name":"Elena","last_name":"Alvarez","full_name":"Alvarez, Elena"},{"last_name":"Spanlang","first_name":"Bernhard","full_name":"Spanlang, Bernhard"},{"full_name":"Pearmund, Charlie","first_name":"Charlie","last_name":"Pearmund"},{"first_name":"Anastasios Polykarpos","last_name":"Athanasiadis","full_name":"Athanasiadis, Anastasios Polykarpos"},{"first_name":"Lisa","last_name":"Otten","full_name":"Otten, Lisa"},{"first_name":"Séverine","last_name":"Pitel","full_name":"Pitel, Séverine"},{"last_name":"Petkoski","first_name":"Spase","full_name":"Petkoski, Spase"},{"full_name":"Jirsa, Viktor","first_name":"Viktor","last_name":"Jirsa"},{"full_name":"Schmitt, Karen","first_name":"Karen","last_name":"Schmitt"},{"last_name":"Wilbertz","first_name":"Johannes","full_name":"Wilbertz, Johannes"},{"last_name":"Patraskaki","first_name":"Myrto","full_name":"Patraskaki, Myrto"},{"first_name":"Peter","last_name":"Sommer","full_name":"Sommer, Peter"},{"full_name":"Heilmann-Heimbach, Stefanie","first_name":"Stefanie","last_name":"Heilmann-Heimbach"},{"first_name":"Carina M.","last_name":"Mathey","full_name":"Mathey, Carina M."},{"full_name":"Miller, Abigail","first_name":"Abigail","last_name":"Miller"},{"first_name":"Isabelle","last_name":"Claus","full_name":"Claus, Isabelle"},{"full_name":"Nöthen, Markus M.","last_name":"Nöthen","first_name":"Markus M."},{"full_name":"Hoffmann, Per","last_name":"Hoffmann","first_name":"Per"},{"full_name":"Forstner, Andreas J.","last_name":"Forstner","first_name":"Andreas J."},{"full_name":"Pastor, Alvaro","first_name":"Alvaro","last_name":"Pastor"},{"last_name":"Gallego","first_name":"Jaime","full_name":"Gallego, Jaime"},{"last_name":"Orosa","first_name":"Francisco Eiroa","full_name":"Orosa, Francisco Eiroa"},{"full_name":"Viapiana, Guillem Feixas","first_name":"Guillem Feixas","last_name":"Viapiana"},{"full_name":"Slater, Mel","last_name":"Slater","first_name":"Mel"},{"full_name":"Marr, Lena","last_name":"Marr","first_name":"Lena","id":"4406F586-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Novarino","first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178"},{"full_name":"Marquand, Andre","last_name":"Marquand","first_name":"Andre"},{"full_name":"Böttger, Sarah Jane","first_name":"Sarah Jane","last_name":"Böttger"},{"full_name":"Tschorn, Mira","first_name":"Mira","last_name":"Tschorn"},{"first_name":"Michael","last_name":"Rapp","full_name":"Rapp, Michael"},{"first_name":"Helga","last_name":"Ask","full_name":"Ask, Helga"},{"full_name":"Kjelkenes, Rikka","last_name":"Kjelkenes","first_name":"Rikka"},{"full_name":"Fernandez, Sara","last_name":"Fernandez","first_name":"Sara"},{"full_name":"Van Der Meer, Dennis","last_name":"Van Der Meer","first_name":"Dennis"},{"full_name":"Westlye, Lars T.","last_name":"Westlye","first_name":"Lars T."},{"first_name":"Ole A.","last_name":"Andreassen","full_name":"Andreassen, Ole A."},{"full_name":"Aden, Rieke","first_name":"Rieke","last_name":"Aden"},{"last_name":"Seefried","first_name":"Beke","full_name":"Seefried, Beke"},{"full_name":"Siehl, Sebastian","last_name":"Siehl","first_name":"Sebastian"},{"first_name":"Frauke","last_name":"Nees","full_name":"Nees, Frauke"},{"full_name":"Neidhart, Maja","first_name":"Maja","last_name":"Neidhart"},{"full_name":"Stringaris, Argyris","first_name":"Argyris","last_name":"Stringaris"},{"last_name":"Schwarz","first_name":"Emanuel","full_name":"Schwarz, Emanuel"},{"last_name":"Holz","first_name":"Nathalie","full_name":"Holz, Nathalie"},{"first_name":"Heike","last_name":"Tost","full_name":"Tost, Heike"},{"full_name":"Meyer-Lindenberg, Andreas","first_name":"Andreas","last_name":"Meyer-Lindenberg"},{"full_name":"Christmann, Nina","last_name":"Christmann","first_name":"Nina"},{"first_name":"Karina","last_name":"Jansone","full_name":"Jansone, Karina"},{"full_name":"Banaschewski, Tobias","first_name":"Tobias","last_name":"Banaschewski"},{"first_name":"Jamie","last_name":"Banks","full_name":"Banks, Jamie"},{"last_name":"Schepanski","first_name":"Kerstin","full_name":"Schepanski, Kerstin"},{"last_name":"Schütz","first_name":"Tatjana","full_name":"Schütz, Tatjana"},{"full_name":"Taron, Ulrike Helene","last_name":"Taron","first_name":"Ulrike Helene"},{"full_name":"Eils, Roland","first_name":"Roland","last_name":"Eils"},{"full_name":"Roy, Jean Charles","first_name":"Jean Charles","last_name":"Roy"},{"first_name":"Tristram A.","last_name":"Lett","full_name":"Lett, Tristram A."},{"last_name":"Kebir","first_name":"Hedi","full_name":"Kebir, Hedi"},{"first_name":"Elli","last_name":"Polemiti","full_name":"Polemiti, Elli"},{"full_name":"Hitchen, Esther","last_name":"Hitchen","first_name":"Esther"},{"last_name":"Jentsch","first_name":"Marcel","full_name":"Jentsch, Marcel"},{"last_name":"Serin","first_name":"Emin","full_name":"Serin, Emin"},{"first_name":"Antoine","last_name":"Bernas","full_name":"Bernas, Antoine"},{"first_name":"Nilakshi","last_name":"Vaidya","full_name":"Vaidya, Nilakshi"},{"first_name":"Sven","last_name":"Twardziok","full_name":"Twardziok, Sven"},{"full_name":"Ralser, Markus","last_name":"Ralser","first_name":"Markus"},{"first_name":"Andreas","last_name":"Heinz","full_name":"Heinz, Andreas"},{"first_name":"Henrik","last_name":"Walter","full_name":"Walter, Henrik"}],"date_created":"2025-08-10T22:01:30Z","publication_identifier":{"eissn":["2731-6076"]},"date_updated":"2025-08-11T06:53:55Z","intvolume":"         2","_id":"20157","year":"2024","date_published":"2024-10-01T00:00:00Z","title":"Rethinking ethics in interdisciplinary and big data-driven neuroscience projects","scopus_import":"1","month":"10","status":"public","language":[{"iso":"eng"}],"article_type":"comment","article_processing_charge":"No"},{"publication":"Nature Mental Health","publisher":"Springer Nature","department":[{"_id":"GaNo"}],"type":"journal_article","publication_status":"published","quality_controlled":"1","acknowledgement":"Funded by the European Union. Complementary funding was received by the UK Research and Innovation (UKRI) under the UK government’s Horizon Europe funding guarantee (10041392 and 10038599). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union, the European Health and Digital Executive Agency (HADEA) or UKRI. The European Union, HADEA and UKRI cannot be held responsible for them. This work received also support from Chinese Ministry for Science and Technology (MOST), the Horizon 2020-funded European Research Council Advanced Grant ‘STRATIFY’ (695313), the German Research Foundation (COPE; 675346; NE 1383/15-1 (CoviDrug)) and the National Natural Science Foundation of China grant 82150710554.","doi":"10.1038/s44220-024-00316-z","issue":"10","citation":{"mla":"Nees, Frauke, et al. “Large-Scale Population Data Enrichment in Mental Health Research.” <i>Nature Mental Health</i>, vol. 2, no. 10, Springer Nature, 2024, pp. 1124–27, doi:<a href=\"https://doi.org/10.1038/s44220-024-00316-z\">10.1038/s44220-024-00316-z</a>.","ista":"Nees F, Renner P, Holz NE, Polemiti E, Siehl S, Hese S, Schepanski K, Schumann G, Walter H, Heinz A, Ralser M, Twardziok S, Vaidya N, Bernas A, Serin E, Jentsch M, Hitchen E, Kebir H, Lett TA, Roy JC, Eils R, Taron UH, Schütz T, Banks J, Banaschewski T, Jansone K, Christmann N, Meyer-Lindenberg A, Tost H, Holz N, Schwarz E, Stringaris A, Neidhart M, Seefried B, Aden R, Andreassen OA, Westlye LT, Van Der Meer D, Fernandez S, Kjelkenes R, Ask H, Rapp M, Tschorn M, Böttger SJ, Marquand A, Novarino G, Marr L, Slater M, Viapiana GF, Orosa FE, Gallego J, Pastor A, Forstner AJ, Hoffmann P, Nöthen MM, Claus I, Miller A, Mathey CM, Heilmann-Heimbach S, Sommer P, Patraskaki M, Wilbertz J, Schmitt K, Jirsa V, Petkoski S, Pitel S, Otten L, Athanasiadis AP, Pearmund C, Spanlang B, Alvarez E, Sanchez M, Giner A, Jia T, Gong Y, Xia Y, Chang X, Calhoun V, Liu J, Schwalber A, Thompson P, Clinton N, Desrivières S, Young AH, Stahl B, Ogoh G. 2024. Large-scale population data enrichment in mental health research. Nature Mental Health. 2(10), 1124–1127.","chicago":"Nees, Frauke, Paul Renner, Nathalie E. Holz, Elli Polemiti, Sebastian Siehl, Sören Hese, Kerstin Schepanski, et al. “Large-Scale Population Data Enrichment in Mental Health Research.” <i>Nature Mental Health</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s44220-024-00316-z\">https://doi.org/10.1038/s44220-024-00316-z</a>.","apa":"Nees, F., Renner, P., Holz, N. E., Polemiti, E., Siehl, S., Hese, S., … Ogoh, G. (2024). Large-scale population data enrichment in mental health research. <i>Nature Mental Health</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s44220-024-00316-z\">https://doi.org/10.1038/s44220-024-00316-z</a>","ama":"Nees F, Renner P, Holz NE, et al. Large-scale population data enrichment in mental health research. <i>Nature Mental Health</i>. 2024;2(10):1124-1127. doi:<a href=\"https://doi.org/10.1038/s44220-024-00316-z\">10.1038/s44220-024-00316-z</a>","short":"F. Nees, P. Renner, N.E. Holz, E. Polemiti, S. Siehl, S. Hese, K. Schepanski, G. Schumann, H. Walter, A. Heinz, M. Ralser, S. Twardziok, N. Vaidya, A. Bernas, E. Serin, M. Jentsch, E. Hitchen, H. Kebir, T.A. Lett, J.C. Roy, R. Eils, U.H. Taron, T. Schütz, J. Banks, T. Banaschewski, K. Jansone, N. Christmann, A. Meyer-Lindenberg, H. Tost, N. Holz, E. Schwarz, A. Stringaris, M. Neidhart, B. Seefried, R. Aden, O.A. Andreassen, L.T. Westlye, D. Van Der Meer, S. Fernandez, R. Kjelkenes, H. Ask, M. Rapp, M. Tschorn, S.J. Böttger, A. Marquand, G. Novarino, L. Marr, M. Slater, G.F. Viapiana, F.E. Orosa, J. Gallego, A. Pastor, A.J. Forstner, P. Hoffmann, M.M. Nöthen, I. Claus, A. Miller, C.M. Mathey, S. Heilmann-Heimbach, P. Sommer, M. Patraskaki, J. Wilbertz, K. Schmitt, V. Jirsa, S. Petkoski, S. Pitel, L. Otten, A.P. Athanasiadis, C. Pearmund, B. Spanlang, E. Alvarez, M. Sanchez, A. Giner, T. Jia, Y. Gong, Y. Xia, X. Chang, V. Calhoun, J. Liu, A. Schwalber, P. Thompson, N. Clinton, S. Desrivières, A.H. Young, B. Stahl, G. Ogoh, Nature Mental Health 2 (2024) 1124–1127.","ieee":"F. Nees <i>et al.</i>, “Large-scale population data enrichment in mental health research,” <i>Nature Mental Health</i>, vol. 2, no. 10. Springer Nature, pp. 1124–1127, 2024."},"day":"01","page":"1124-1127","abstract":[{"lang":"eng","text":"This Comment explores new approaches to enrich large-scale population data, including incorporating macro-environmental and digital health measures."}],"oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"closed access","volume":2,"publication_identifier":{"eissn":["2731-6076"]},"date_updated":"2025-03-25T08:28:39Z","author":[{"last_name":"Nees","first_name":"Frauke","full_name":"Nees, Frauke"},{"first_name":"Paul","last_name":"Renner","full_name":"Renner, Paul"},{"first_name":"Nathalie E.","last_name":"Holz","full_name":"Holz, Nathalie E."},{"last_name":"Polemiti","first_name":"Elli","full_name":"Polemiti, Elli"},{"full_name":"Siehl, Sebastian","first_name":"Sebastian","last_name":"Siehl"},{"full_name":"Hese, Sören","last_name":"Hese","first_name":"Sören"},{"full_name":"Schepanski, Kerstin","first_name":"Kerstin","last_name":"Schepanski"},{"last_name":"Schumann","first_name":"Gunter","full_name":"Schumann, Gunter"},{"last_name":"Walter","first_name":"Henrik","full_name":"Walter, Henrik"},{"full_name":"Heinz, Andreas","first_name":"Andreas","last_name":"Heinz"},{"full_name":"Ralser, Markus","first_name":"Markus","last_name":"Ralser"},{"last_name":"Twardziok","first_name":"Sven","full_name":"Twardziok, Sven"},{"last_name":"Vaidya","first_name":"Nilakshi","full_name":"Vaidya, Nilakshi"},{"full_name":"Bernas, Antoine","first_name":"Antoine","last_name":"Bernas"},{"full_name":"Serin, Emin","first_name":"Emin","last_name":"Serin"},{"full_name":"Jentsch, Marcel","first_name":"Marcel","last_name":"Jentsch"},{"full_name":"Hitchen, Esther","last_name":"Hitchen","first_name":"Esther"},{"full_name":"Kebir, Hedi","last_name":"Kebir","first_name":"Hedi"},{"first_name":"Tristram A.","last_name":"Lett","full_name":"Lett, Tristram A."},{"full_name":"Roy, Jean Charles","last_name":"Roy","first_name":"Jean Charles"},{"full_name":"Eils, Roland","last_name":"Eils","first_name":"Roland"},{"full_name":"Taron, Ulrike Helene","first_name":"Ulrike Helene","last_name":"Taron"},{"full_name":"Schütz, Tatjana","first_name":"Tatjana","last_name":"Schütz"},{"first_name":"Jamie","last_name":"Banks","full_name":"Banks, Jamie"},{"full_name":"Banaschewski, Tobias","first_name":"Tobias","last_name":"Banaschewski"},{"first_name":"Karina","last_name":"Jansone","full_name":"Jansone, Karina"},{"full_name":"Christmann, Nina","last_name":"Christmann","first_name":"Nina"},{"full_name":"Meyer-Lindenberg, Andreas","last_name":"Meyer-Lindenberg","first_name":"Andreas"},{"first_name":"Heike","last_name":"Tost","full_name":"Tost, Heike"},{"full_name":"Holz, Nathalie","last_name":"Holz","first_name":"Nathalie"},{"full_name":"Schwarz, Emanuel","last_name":"Schwarz","first_name":"Emanuel"},{"full_name":"Stringaris, Argyris","last_name":"Stringaris","first_name":"Argyris"},{"last_name":"Neidhart","first_name":"Maja","full_name":"Neidhart, Maja"},{"last_name":"Seefried","first_name":"Beke","full_name":"Seefried, Beke"},{"first_name":"Rieke","last_name":"Aden","full_name":"Aden, Rieke"},{"full_name":"Andreassen, Ole A.","last_name":"Andreassen","first_name":"Ole A."},{"first_name":"Lars T.","last_name":"Westlye","full_name":"Westlye, Lars T."},{"full_name":"Van Der Meer, Dennis","first_name":"Dennis","last_name":"Van Der Meer"},{"full_name":"Fernandez, Sara","last_name":"Fernandez","first_name":"Sara"},{"last_name":"Kjelkenes","first_name":"Rikka","full_name":"Kjelkenes, Rikka"},{"full_name":"Ask, Helga","first_name":"Helga","last_name":"Ask"},{"full_name":"Rapp, Michael","first_name":"Michael","last_name":"Rapp"},{"full_name":"Tschorn, Mira","first_name":"Mira","last_name":"Tschorn"},{"full_name":"Böttger, Sarah Jane","first_name":"Sarah Jane","last_name":"Böttger"},{"full_name":"Marquand, Andre","first_name":"Andre","last_name":"Marquand"},{"full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","first_name":"Gaia"},{"full_name":"Marr, Lena","id":"4406F586-F248-11E8-B48F-1D18A9856A87","first_name":"Lena","last_name":"Marr"},{"first_name":"Mel","last_name":"Slater","full_name":"Slater, Mel"},{"first_name":"Guillem Feixas","last_name":"Viapiana","full_name":"Viapiana, Guillem Feixas"},{"full_name":"Orosa, Francisco Eiroa","first_name":"Francisco Eiroa","last_name":"Orosa"},{"last_name":"Gallego","first_name":"Jaime","full_name":"Gallego, Jaime"},{"last_name":"Pastor","first_name":"Alvaro","full_name":"Pastor, Alvaro"},{"first_name":"Andreas J.","last_name":"Forstner","full_name":"Forstner, Andreas J."},{"full_name":"Hoffmann, Per","first_name":"Per","last_name":"Hoffmann"},{"full_name":"Nöthen, Markus M.","first_name":"Markus M.","last_name":"Nöthen"},{"last_name":"Claus","first_name":"Isabelle","full_name":"Claus, Isabelle"},{"full_name":"Miller, Abigail","last_name":"Miller","first_name":"Abigail"},{"full_name":"Mathey, Carina M.","first_name":"Carina M.","last_name":"Mathey"},{"last_name":"Heilmann-Heimbach","first_name":"Stefanie","full_name":"Heilmann-Heimbach, Stefanie"},{"first_name":"Peter","last_name":"Sommer","full_name":"Sommer, Peter"},{"first_name":"Myrto","last_name":"Patraskaki","full_name":"Patraskaki, Myrto"},{"first_name":"Johannes","last_name":"Wilbertz","full_name":"Wilbertz, Johannes"},{"full_name":"Schmitt, Karen","last_name":"Schmitt","first_name":"Karen"},{"full_name":"Jirsa, Viktor","first_name":"Viktor","last_name":"Jirsa"},{"last_name":"Petkoski","first_name":"Spase","full_name":"Petkoski, Spase"},{"last_name":"Pitel","first_name":"Séverine","full_name":"Pitel, Séverine"},{"last_name":"Otten","first_name":"Lisa","full_name":"Otten, Lisa"},{"full_name":"Athanasiadis, Anastasios Polykarpos","last_name":"Athanasiadis","first_name":"Anastasios Polykarpos"},{"last_name":"Pearmund","first_name":"Charlie","full_name":"Pearmund, Charlie"},{"full_name":"Spanlang, Bernhard","first_name":"Bernhard","last_name":"Spanlang"},{"full_name":"Alvarez, Elena","first_name":"Elena","last_name":"Alvarez"},{"last_name":"Sanchez","first_name":"Mavi","full_name":"Sanchez, Mavi"},{"first_name":"Arantxa","last_name":"Giner","full_name":"Giner, Arantxa"},{"full_name":"Jia, Tianye","first_name":"Tianye","last_name":"Jia"},{"first_name":"Yanting","last_name":"Gong","full_name":"Gong, Yanting"},{"first_name":"Yunman","last_name":"Xia","full_name":"Xia, Yunman"},{"last_name":"Chang","first_name":"Xiao","full_name":"Chang, Xiao"},{"first_name":"Vince","last_name":"Calhoun","full_name":"Calhoun, Vince"},{"last_name":"Liu","first_name":"Jingyu","full_name":"Liu, Jingyu"},{"full_name":"Schwalber, Ameli","last_name":"Schwalber","first_name":"Ameli"},{"last_name":"Thompson","first_name":"Paul","full_name":"Thompson, Paul"},{"full_name":"Clinton, Nicholas","first_name":"Nicholas","last_name":"Clinton"},{"last_name":"Desrivières","first_name":"Sylvane","full_name":"Desrivières, Sylvane"},{"last_name":"Young","first_name":"Allan H.","full_name":"Young, Allan H."},{"full_name":"Stahl, Bernd","first_name":"Bernd","last_name":"Stahl"},{"full_name":"Ogoh, George","first_name":"George","last_name":"Ogoh"}],"date_created":"2025-03-23T23:01:28Z","date_published":"2024-10-01T00:00:00Z","title":"Large-scale population data enrichment in mental health research","month":"10","scopus_import":"1","intvolume":"         2","_id":"19446","year":"2024","language":[{"iso":"eng"}],"article_type":"letter_note","article_processing_charge":"No","status":"public"},{"file_date_updated":"2023-06-26T10:15:44Z","page":"1456-1467","license":"https://creativecommons.org/licenses/by/4.0/","doi":"10.1038/s41591-023-02365-w","acknowledgement":"This work received support from the European Union-funded Horizon Europe project ‘environMENTAL’ (no. 101057429 to G.S., A.M. and M.M.N.) and cofunding by UK Research and Innovation under the UK Government’s Horizon Europe funding guarantee (nos. 10041392 and 10038599) for study design and data analysis; the Horizon 2020-funded European Research Council Advanced Grant ‘STRATIFY’ (no. 695313 to G.S. for study design and data analysis); the Human Brain Project (HBP SGA3, no. 945539 to G.S. for study design and data analysis); the National Institutes of Health (grant no. R01DA049238 to G.S. for study design and data analysis); the German Research Foundation (COPE; grant no. 675346 to G.S. for study design and data analysis); the National Natural Science Foundation of China (grant no. 82001797 to J.X., grant no. 82030053 to C.Y., grant no. 82202093 to J.T. and grant no. 82150710554 to G.S. for study design, data analysis and preparation of the manuscript); National Key Research and Development Program of China (grant no. 2018YFC1314301 to C.Y. for study design and data analysis); Tianjin Applied Basic Research Diversified Investment Foundation (grant no. 21JCYBJC01360 to J.X. for study design and data analysis); Tianjin Health Technology Project (grant no. TJWJ2021QN002 to J.X. for preparation of the manuscript); Science & Technology Development Fund of the Tianjin Education Commission for Higher Education (grant no. 2019KJ195 to J.X. for preparation of the manuscript); the Tianjin Medical University ‘Clinical Talent Training 123 Climbing Plan’ to J.X. for the preparation of the manuscript; Tianjin Key Medical Discipline (Specialty) Construction Project (grant no. TJYXZDXK-001A to C.Y. for preparation of the manuscript); the National Key R&D Program of China (grant no. 2022YFE0209400 to L.Y. for study design and data analysis); the Tsinghua University Initiative Scientific Research Program (grant no. 2021Z11GHX002 to L.Y. for study design and data analysis); the National Key Scientific and Technological Infrastructure Project ‘Earth System Science Numerical Simulator Facility’ (EarthLab to L.Y. for study design and data analysis); the Chinese National High-end Foreign Expert Recruitment Plan to G.S.; and the Alexander von Humboldt Foundation to G.S. for study design and data analysis.","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"15","isi":1,"citation":{"mla":"Xu, Jiayuan, et al. “Effects of Urban Living Environments on Mental Health in Adults.” <i>Nature Medicine</i>, vol. 29, Springer Nature, 2023, pp. 1456–67, doi:<a href=\"https://doi.org/10.1038/s41591-023-02365-w\">10.1038/s41591-023-02365-w</a>.","ista":"Xu J, Liu N, Polemiti E, Garcia-Mondragon L, Tang J, Liu X, Lett T, Yu L, Nöthen MM, Feng J, Yu C, Marquand A, Schumann G, Walter H, Heinz A, Ralser M, Twardziok S, Vaidya N, Serin E, Jentsch M, Hitchen E, Eils R, Taron UH, Schütz T, Schepanski K, Banks J, Banaschewski T, Jansone K, Christmann N, Meyer-Lindenberg A, Tost H, Holz N, Schwarz E, Stringaris A, Neidhart M, Nees F, Siehl S, A. Andreassen O, T. Westlye L, Van Der Meer D, Fernandez S, Kjelkenes R, Ask H, Rapp M, Tschorn M, Böttger SJ, Novarino G, Marr L, Slater M, Viapiana GF, Orosa FE, Gallego J, Pastor A, Forstner A, Hoffmann P, M. Nöthen M, J. Forstner A, Claus I, Miller A, Heilmann-Heimbach S, Sommer P, Boye M, Wilbertz J, Schmitt K, Jirsa V, Petkoski S, Pitel S, Otten L, Athanasiadis AP, Pearmund C, Spanlang B, Alvarez E, Sanchez M, Giner A, Hese S, Renner P, Jia T, Gong Y, Xia Y, Chang X, Calhoun V, Liu J, Thompson P, Clinton N, Desrivieres S, H. Young A, Stahl B, Ogoh G. 2023. Effects of urban living environments on mental health in adults. Nature Medicine. 29, 1456–1467.","chicago":"Xu, Jiayuan, Nana Liu, Elli Polemiti, Liliana Garcia-Mondragon, Jie Tang, Xiaoxuan Liu, Tristram Lett, et al. “Effects of Urban Living Environments on Mental Health in Adults.” <i>Nature Medicine</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41591-023-02365-w\">https://doi.org/10.1038/s41591-023-02365-w</a>.","ama":"Xu J, Liu N, Polemiti E, et al. Effects of urban living environments on mental health in adults. <i>Nature Medicine</i>. 2023;29:1456-1467. doi:<a href=\"https://doi.org/10.1038/s41591-023-02365-w\">10.1038/s41591-023-02365-w</a>","apa":"Xu, J., Liu, N., Polemiti, E., Garcia-Mondragon, L., Tang, J., Liu, X., … Ogoh, G. (2023). Effects of urban living environments on mental health in adults. <i>Nature Medicine</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41591-023-02365-w\">https://doi.org/10.1038/s41591-023-02365-w</a>","short":"J. Xu, N. Liu, E. Polemiti, L. Garcia-Mondragon, J. Tang, X. Liu, T. Lett, L. Yu, M.M. Nöthen, J. Feng, C. Yu, A. Marquand, G. Schumann, H. Walter, A. Heinz, M. Ralser, S. Twardziok, N. Vaidya, E. Serin, M. Jentsch, E. Hitchen, R. Eils, U.H. Taron, T. Schütz, K. Schepanski, J. Banks, T. Banaschewski, K. Jansone, N. Christmann, A. Meyer-Lindenberg, H. Tost, N. Holz, E. Schwarz, A. Stringaris, M. Neidhart, F. Nees, S. Siehl, O. A. Andreassen, L. T. Westlye, D. Van Der Meer, S. Fernandez, R. Kjelkenes, H. Ask, M. Rapp, M. Tschorn, S.J. Böttger, G. Novarino, L. Marr, M. Slater, G.F. Viapiana, F.E. Orosa, J. Gallego, A. Pastor, A. Forstner, P. Hoffmann, M. M. Nöthen, A. J. Forstner, I. Claus, A. Miller, S. Heilmann-Heimbach, P. Sommer, M. Boye, J. Wilbertz, K. Schmitt, V. Jirsa, S. Petkoski, S. Pitel, L. Otten, A.P. Athanasiadis, C. Pearmund, B. Spanlang, E. Alvarez, M. Sanchez, A. Giner, S. Hese, P. Renner, T. Jia, Y. Gong, Y. Xia, X. Chang, V. Calhoun, J. Liu, P. Thompson, N. Clinton, S. Desrivieres, A. H. Young, B. Stahl, G. Ogoh, Nature Medicine 29 (2023) 1456–1467.","ieee":"J. Xu <i>et al.</i>, “Effects of urban living environments on mental health in adults,” <i>Nature Medicine</i>, vol. 29. Springer Nature, pp. 1456–1467, 2023."},"department":[{"_id":"GaNo"}],"file":[{"content_type":"application/pdf","file_size":7365360,"file_id":"13171","success":1,"date_updated":"2023-06-26T10:15:44Z","file_name":"2023_NatureMedicine_Xu.pdf","checksum":"bcd3225b2731c3442fa98987fd3bd46d","access_level":"open_access","creator":"dernst","relation":"main_file","date_created":"2023-06-26T10:15:44Z"}],"publication_status":"published","type":"journal_article","quality_controlled":"1","ddc":["570"],"publication":"Nature Medicine","publisher":"Springer Nature","has_accepted_license":"1","language":[{"iso":"eng"}],"article_processing_charge":"No","article_type":"original","status":"public","date_published":"2023-06-15T00:00:00Z","month":"06","scopus_import":"1","title":"Effects of urban living environments on mental health in adults","intvolume":"        29","year":"2023","_id":"13168","publication_identifier":{"issn":["1078-8956"],"eissn":["1546-170X"]},"date_updated":"2023-12-13T11:25:55Z","date_created":"2023-06-25T22:00:46Z","author":[{"first_name":"Jiayuan","last_name":"Xu","full_name":"Xu, Jiayuan"},{"full_name":"Liu, Nana","first_name":"Nana","last_name":"Liu"},{"full_name":"Polemiti, Elli","last_name":"Polemiti","first_name":"Elli"},{"full_name":"Garcia-Mondragon, Liliana","last_name":"Garcia-Mondragon","first_name":"Liliana"},{"full_name":"Tang, Jie","first_name":"Jie","last_name":"Tang"},{"first_name":"Xiaoxuan","last_name":"Liu","full_name":"Liu, Xiaoxuan"},{"full_name":"Lett, Tristram","last_name":"Lett","first_name":"Tristram"},{"first_name":"Le","last_name":"Yu","full_name":"Yu, Le"},{"last_name":"Nöthen","first_name":"Markus M.","full_name":"Nöthen, Markus M."},{"first_name":"Jianfeng","last_name":"Feng","full_name":"Feng, Jianfeng"},{"full_name":"Yu, Chunshui","first_name":"Chunshui","last_name":"Yu"},{"full_name":"Marquand, Andre","last_name":"Marquand","first_name":"Andre"},{"full_name":"Schumann, Gunter","first_name":"Gunter","last_name":"Schumann"},{"last_name":"Walter","first_name":"Henrik","full_name":"Walter, Henrik"},{"full_name":"Heinz, Andreas","first_name":"Andreas","last_name":"Heinz"},{"full_name":"Ralser, Markus","last_name":"Ralser","first_name":"Markus"},{"full_name":"Twardziok, Sven","last_name":"Twardziok","first_name":"Sven"},{"last_name":"Vaidya","first_name":"Nilakshi","full_name":"Vaidya, Nilakshi"},{"full_name":"Serin, Emin","last_name":"Serin","first_name":"Emin"},{"full_name":"Jentsch, Marcel","first_name":"Marcel","last_name":"Jentsch"},{"first_name":"Esther","last_name":"Hitchen","full_name":"Hitchen, Esther"},{"first_name":"Roland","last_name":"Eils","full_name":"Eils, Roland"},{"first_name":"Ulrike Helene","last_name":"Taron","full_name":"Taron, Ulrike Helene"},{"last_name":"Schütz","first_name":"Tatjana","full_name":"Schütz, Tatjana"},{"last_name":"Schepanski","first_name":"Kerstin","full_name":"Schepanski, Kerstin"},{"full_name":"Banks, Jamie","last_name":"Banks","first_name":"Jamie"},{"last_name":"Banaschewski","first_name":"Tobias","full_name":"Banaschewski, Tobias"},{"last_name":"Jansone","first_name":"Karina","full_name":"Jansone, Karina"},{"full_name":"Christmann, Nina","first_name":"Nina","last_name":"Christmann"},{"full_name":"Meyer-Lindenberg, Andreas","first_name":"Andreas","last_name":"Meyer-Lindenberg"},{"full_name":"Tost, Heike","first_name":"Heike","last_name":"Tost"},{"full_name":"Holz, Nathalie","last_name":"Holz","first_name":"Nathalie"},{"full_name":"Schwarz, Emanuel","last_name":"Schwarz","first_name":"Emanuel"},{"last_name":"Stringaris","first_name":"Argyris","full_name":"Stringaris, Argyris"},{"full_name":"Neidhart, Maja","first_name":"Maja","last_name":"Neidhart"},{"last_name":"Nees","first_name":"Frauke","full_name":"Nees, Frauke"},{"full_name":"Siehl, Sebastian","first_name":"Sebastian","last_name":"Siehl"},{"full_name":"A. 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Westlye"},{"first_name":"Dennis","last_name":"Van Der Meer","full_name":"Van Der Meer, Dennis"},{"last_name":"Fernandez","first_name":"Sara","full_name":"Fernandez, Sara"},{"full_name":"Kjelkenes, Rikka","last_name":"Kjelkenes","first_name":"Rikka"},{"full_name":"Ask, Helga","first_name":"Helga","last_name":"Ask"},{"last_name":"Rapp","first_name":"Michael","full_name":"Rapp, Michael"},{"full_name":"Tschorn, Mira","first_name":"Mira","last_name":"Tschorn"},{"full_name":"Böttger, Sarah Jane","last_name":"Böttger","first_name":"Sarah Jane"},{"orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia","first_name":"Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Marr, Lena","last_name":"Marr","first_name":"Lena","id":"4406F586-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Slater","first_name":"Mel","full_name":"Slater, Mel"},{"full_name":"Viapiana, Guillem Feixas","last_name":"Viapiana","first_name":"Guillem Feixas"},{"first_name":"Francisco Eiroa","last_name":"Orosa","full_name":"Orosa, Francisco Eiroa"},{"full_name":"Gallego, Jaime","first_name":"Jaime","last_name":"Gallego"},{"last_name":"Pastor","first_name":"Alvaro","full_name":"Pastor, Alvaro"},{"full_name":"Forstner, Andreas","last_name":"Forstner","first_name":"Andreas"},{"first_name":"Per","last_name":"Hoffmann","full_name":"Hoffmann, Per"},{"last_name":"M. Nöthen","first_name":"Markus","full_name":"M. Nöthen, Markus"},{"full_name":"J. Forstner, Andreas","last_name":"J. Forstner","first_name":"Andreas"},{"last_name":"Claus","first_name":"Isabelle","full_name":"Claus, Isabelle"},{"last_name":"Miller","first_name":"Abbi","full_name":"Miller, Abbi"},{"last_name":"Heilmann-Heimbach","first_name":"Stefanie","full_name":"Heilmann-Heimbach, Stefanie"},{"last_name":"Sommer","first_name":"Peter","full_name":"Sommer, Peter"},{"last_name":"Boye","first_name":"Mona","full_name":"Boye, Mona"},{"first_name":"Johannes","last_name":"Wilbertz","full_name":"Wilbertz, Johannes"},{"full_name":"Schmitt, Karen","first_name":"Karen","last_name":"Schmitt"},{"full_name":"Jirsa, Viktor","first_name":"Viktor","last_name":"Jirsa"},{"full_name":"Petkoski, Spase","last_name":"Petkoski","first_name":"Spase"},{"full_name":"Pitel, Séverine","first_name":"Séverine","last_name":"Pitel"},{"full_name":"Otten, Lisa","last_name":"Otten","first_name":"Lisa"},{"full_name":"Athanasiadis, Anastasios Polykarpos","first_name":"Anastasios Polykarpos","last_name":"Athanasiadis"},{"last_name":"Pearmund","first_name":"Charlie","full_name":"Pearmund, Charlie"},{"full_name":"Spanlang, Bernhard","first_name":"Bernhard","last_name":"Spanlang"},{"full_name":"Alvarez, Elena","last_name":"Alvarez","first_name":"Elena"},{"first_name":"Mavi","last_name":"Sanchez","full_name":"Sanchez, Mavi"},{"full_name":"Giner, Arantxa","first_name":"Arantxa","last_name":"Giner"},{"last_name":"Hese","first_name":"Sören","full_name":"Hese, Sören"},{"first_name":"Paul","last_name":"Renner","full_name":"Renner, Paul"},{"full_name":"Jia, Tianye","last_name":"Jia","first_name":"Tianye"},{"full_name":"Gong, Yanting","first_name":"Yanting","last_name":"Gong"},{"last_name":"Xia","first_name":"Yunman","full_name":"Xia, Yunman"},{"first_name":"Xiao","last_name":"Chang","full_name":"Chang, Xiao"},{"last_name":"Calhoun","first_name":"Vince","full_name":"Calhoun, Vince"},{"full_name":"Liu, Jingyu","first_name":"Jingyu","last_name":"Liu"},{"last_name":"Thompson","first_name":"Paul","full_name":"Thompson, Paul"},{"full_name":"Clinton, Nicholas","last_name":"Clinton","first_name":"Nicholas"},{"full_name":"Desrivieres, Sylvane","first_name":"Sylvane","last_name":"Desrivieres"},{"full_name":"H. Young, Allan","first_name":"Allan","last_name":"H. Young"},{"first_name":"Bernd","last_name":"Stahl","full_name":"Stahl, Bernd"},{"full_name":"Ogoh, George","last_name":"Ogoh","first_name":"George"}],"abstract":[{"text":"Urban-living individuals are exposed to many environmental factors that may combine and interact to influence mental health. While individual factors of an urban environment have been investigated in isolation, no attempt has been made to model how complex, real-life exposure to living in the city relates to brain and mental health, and how this is moderated by genetic factors. Using the data of 156,075 participants from the UK Biobank, we carried out sparse canonical correlation analyses to investigate the relationships between urban environments and psychiatric symptoms. We found an environmental profile of social deprivation, air pollution, street network and urban land-use density that was positively correlated with an affective symptom group (r = 0.22, Pperm < 0.001), mediated by brain volume differences consistent with reward processing, and moderated by genes enriched for stress response, including CRHR1, explaining 2.01% of the variance in brain volume differences. Protective factors such as greenness and generous destination accessibility were negatively correlated with an anxiety symptom group (r = 0.10, Pperm < 0.001), mediated by brain regions necessary for emotion regulation and moderated by EXD3, explaining 1.65% of the variance. The third urban environmental profile was correlated with an emotional instability symptom group (r = 0.03, Pperm < 0.001). Our findings suggest that different environmental profiles of urban living may influence specific psychiatric symptom groups through distinct neurobiological pathways.","lang":"eng"}],"oa_version":"Published Version","external_id":{"isi":["001013172700001"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":29,"oa":1}]