[{"day":"12","doi":"10.15479/AT-ISTA-21442","has_accepted_license":"1","file":[{"relation":"main_file","checksum":"441c8827717dcda05f91c127d15cf1e9","file_name":"ca3simu-vargas2026v1.tar.gz","date_created":"2026-03-12T08:19:14Z","success":1,"access_level":"open_access","creator":"schloegl","content_type":"application/gzip","date_updated":"2026-03-12T08:19:14Z","file_size":160410,"file_id":"21443"},{"file_name":"README.md","checksum":"3c0092076228a15c0a7ae703192d43ea","date_created":"2026-03-12T10:24:45Z","relation":"main_file","date_updated":"2026-03-12T10:24:45Z","file_size":10923,"file_id":"21445","success":1,"access_level":"open_access","creator":"schloegl","content_type":"text/markdown"}],"project":[{"_id":"e62b56fe-ab3c-11f0-94c7-d181dd352b3b","name":"Synaptic mechanisms of engram storage and retrieval in CA3 hippocampal microcircuits","grant_number":"101199096"},{"grant_number":"P36232","name":"Mechanisms of GABA release in hippocampal circuits","_id":"bd88be38-d553-11ed-ba76-81d5a70a6ef5"},{"name":"Synaptic networks of human brain","grant_number":"PAT 4178023","_id":"8d9195e9-16d5-11f0-9cad-d075be887a1e"},{"name":"Biophysics and circuit function of a giant cortical glutamatergic synapse","grant_number":"692692","call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425"}],"department":[{"_id":"ScienComp"},{"_id":"PeJo"}],"license":"https://opensource.org/licenses/GPL-3.0","keyword":["hypocampus","ca3 simulations","modelling"],"oa":1,"status":"public","citation":{"short":"A. Schlögl, (2026).","ama":"Schlögl A. CA3Simu v1.06 (vargas2026v1). 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21442\">10.15479/AT-ISTA-21442</a>","chicago":"Schlögl, Alois. “CA3Simu v1.06 (Vargas2026v1).” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21442\">https://doi.org/10.15479/AT-ISTA-21442</a>.","mla":"Schlögl, Alois. <i>CA3Simu v1.06 (Vargas2026v1)</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21442\">10.15479/AT-ISTA-21442</a>.","ista":"Schlögl A. 2026. CA3Simu v1.06 (vargas2026v1), Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21442\">10.15479/AT-ISTA-21442</a>.","apa":"Schlögl, A. (2026). CA3Simu v1.06 (vargas2026v1). Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21442\">https://doi.org/10.15479/AT-ISTA-21442</a>","ieee":"A. Schlögl, “CA3Simu v1.06 (vargas2026v1).” Institute of Science and Technology Austria, 2026."},"publisher":"Institute of Science and Technology Austria","date_published":"2026-03-12T00:00:00Z","date_created":"2026-03-12T08:20:46Z","file_date_updated":"2026-03-12T10:24:45Z","title":"CA3Simu v1.06 (vargas2026v1)","corr_author":"1","date_updated":"2026-03-12T11:28:52Z","year":"2026","_id":"21442","month":"03","ec_funded":1,"tmp":{"short":"GPL 3.0","name":"GNU General Public License 3.0","legal_code_url":"https://www.gnu.org/licenses/gpl-3.0.en.html"},"author":[{"full_name":"Schlögl, Alois","orcid":"0000-0002-5621-8100","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","last_name":"Schlögl"}],"user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","type":"software"},{"publication_status":"published","department":[{"_id":"ScienComp"}],"publisher":"EuroCC Austria","oa":1,"citation":{"mla":"Schlögl, Alois, et al. “How Much Memory per CPU Core Is Requested?” <i>ASHPC24 - Austrian-Slovenian HPC Meeting 2024</i>, EuroCC Austria, 2024, p. 46, doi:<a href=\"https://doi.org/10.25365/phaidra.463\">10.25365/phaidra.463</a>.","ieee":"A. Schlögl, W. Khalid, S. Elefante, and S. Stadlbauer, “How much memory per CPU core is requested?,” in <i>ASHPC24 - Austrian-Slovenian HPC Meeting 2024</i>, Grundlsee, Austria, 2024, p. 46.","apa":"Schlögl, A., Khalid, W., Elefante, S., &#38; Stadlbauer, S. (2024). How much memory per CPU core is requested? In <i>ASHPC24 - Austrian-Slovenian HPC Meeting 2024</i> (p. 46). Grundlsee, Austria: EuroCC Austria. <a href=\"https://doi.org/10.25365/phaidra.463\">https://doi.org/10.25365/phaidra.463</a>","ista":"Schlögl A, Khalid W, Elefante S, Stadlbauer S. 2024. How much memory per CPU core is requested? ASHPC24 - Austrian-Slovenian HPC Meeting 2024. ASHPC: Austrian-Slovenian HPC Meeting, 46.","chicago":"Schlögl, Alois, Waleed Khalid, Stefano Elefante, and Stephan Stadlbauer. “How Much Memory per CPU Core Is Requested?” In <i>ASHPC24 - Austrian-Slovenian HPC Meeting 2024</i>, 46. EuroCC Austria, 2024. <a href=\"https://doi.org/10.25365/phaidra.463\">https://doi.org/10.25365/phaidra.463</a>.","short":"A. Schlögl, W. Khalid, S. Elefante, S. Stadlbauer, in:, ASHPC24 - Austrian-Slovenian HPC Meeting 2024, EuroCC Austria, 2024, p. 46.","ama":"Schlögl A, Khalid W, Elefante S, Stadlbauer S. How much memory per CPU core is requested? In: <i>ASHPC24 - Austrian-Slovenian HPC Meeting 2024</i>. EuroCC Austria; 2024:46. doi:<a href=\"https://doi.org/10.25365/phaidra.463\">10.25365/phaidra.463</a>"},"day":"13","oa_version":"Published Version","doi":"10.25365/phaidra.463","conference":{"name":"ASHPC: Austrian-Slovenian HPC Meeting","location":"Grundlsee, Austria","start_date":"2024-06-10","end_date":"2024-06-13"},"has_accepted_license":"1","type":"conference_abstract","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ddc":["000"],"title":"How much memory per CPU core is requested?","month":"06","date_updated":"2024-06-17T09:40:37Z","_id":"17139","article_processing_charge":"No","date_created":"2024-06-14T09:06:36Z","date_published":"2024-06-13T00:00:00Z","status":"public","file":[{"success":1,"creator":"dernst","access_level":"open_access","content_type":"application/pdf","date_updated":"2024-06-17T09:36:51Z","file_size":206746,"file_id":"17153","relation":"main_file","checksum":"f7d3dded6df2dcdb4818904cf2e1c183","file_name":"2024_ASHPC_Schloegl.pdf","date_created":"2024-06-17T09:36:51Z"}],"page":"46","quality_controlled":"1","author":[{"first_name":"Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","full_name":"Schlögl, Alois","orcid":"0000-0002-5621-8100","last_name":"Schlögl"},{"last_name":"Khalid","id":"097c0562-3cf0-11ee-8fd3-e7a79c1e2fd1","first_name":"Waleed","full_name":"Khalid, Waleed"},{"first_name":"Stefano","id":"490F40CE-F248-11E8-B48F-1D18A9856A87","full_name":"Elefante, Stefano","last_name":"Elefante"},{"id":"4D0BC184-F248-11E8-B48F-1D18A9856A87","first_name":"Stephan","full_name":"Stadlbauer, Stephan","last_name":"Stadlbauer"}],"file_date_updated":"2024-06-17T09:36:51Z","publication_identifier":{"isbn":["9783200096455"]},"year":"2024","publication":"ASHPC24 - Austrian-Slovenian HPC Meeting 2024","language":[{"iso":"eng"}]},{"project":[{"name":"Structural conservation and diversity in retroviral capsid","grant_number":"P31445","_id":"26736D6A-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"has_accepted_license":"1","scopus_import":"1","volume":31,"oa_version":"Published Version","day":"01","doi":"10.1038/s41594-023-01201-6","publisher":"Springer Nature","oa":1,"citation":{"chicago":"Datler, Julia, Jesse Hansen, Andreas Thader, Alois Schlögl, Lukas W Bauer, Victor-Valentin Hodirnau, and Florian KM Schur. “Multi-Modal Cryo-EM Reveals Trimers of Protein A10 to Form the Palisade Layer in Poxvirus Cores.” <i>Nature Structural &#38; Molecular Biology</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41594-023-01201-6\">https://doi.org/10.1038/s41594-023-01201-6</a>.","ama":"Datler J, Hansen J, Thader A, et al. Multi-modal cryo-EM reveals trimers of protein A10 to form the palisade layer in poxvirus cores. <i>Nature Structural &#38; Molecular Biology</i>. 2024;31:1114-1123. doi:<a href=\"https://doi.org/10.1038/s41594-023-01201-6\">10.1038/s41594-023-01201-6</a>","short":"J. Datler, J. Hansen, A. Thader, A. Schlögl, L.W. Bauer, V.-V. Hodirnau, F.K. Schur, Nature Structural &#38; Molecular Biology 31 (2024) 1114–1123.","mla":"Datler, Julia, et al. “Multi-Modal Cryo-EM Reveals Trimers of Protein A10 to Form the Palisade Layer in Poxvirus Cores.” <i>Nature Structural &#38; Molecular Biology</i>, vol. 31, Springer Nature, 2024, pp. 1114–23, doi:<a href=\"https://doi.org/10.1038/s41594-023-01201-6\">10.1038/s41594-023-01201-6</a>.","ieee":"J. Datler <i>et al.</i>, “Multi-modal cryo-EM reveals trimers of protein A10 to form the palisade layer in poxvirus cores,” <i>Nature Structural &#38; Molecular Biology</i>, vol. 31. Springer Nature, pp. 1114–1123, 2024.","apa":"Datler, J., Hansen, J., Thader, A., Schlögl, A., Bauer, L. W., Hodirnau, V.-V., &#38; Schur, F. K. (2024). Multi-modal cryo-EM reveals trimers of protein A10 to form the palisade layer in poxvirus cores. <i>Nature Structural &#38; Molecular Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41594-023-01201-6\">https://doi.org/10.1038/s41594-023-01201-6</a>","ista":"Datler J, Hansen J, Thader A, Schlögl A, Bauer LW, Hodirnau V-V, Schur FK. 2024. Multi-modal cryo-EM reveals trimers of protein A10 to form the palisade layer in poxvirus cores. Nature Structural &#38; Molecular Biology. 31, 1114–1123."},"keyword":["Molecular Biology","Structural Biology"],"intvolume":"        31","publication_status":"published","department":[{"_id":"FlSc"},{"_id":"ScienComp"},{"_id":"EM-Fac"}],"month":"07","date_updated":"2026-04-07T12:59:44Z","_id":"14979","corr_author":"1","APC_amount":"11700 EUR","title":"Multi-modal cryo-EM reveals trimers of protein A10 to form the palisade layer in poxvirus cores","ddc":["570"],"type":"journal_article","pmid":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","file":[{"relation":"main_file","date_created":"2024-07-22T11:27:22Z","checksum":"bda7bf65d81455480efaed8ca293b0db","file_name":"2024_NatureStrucBio_Datler.pdf","content_type":"application/pdf","success":1,"creator":"dernst","access_level":"open_access","file_id":"17307","date_updated":"2024-07-22T11:27:22Z","file_size":17485494}],"abstract":[{"text":"Poxviruses are among the largest double-stranded DNA viruses, with members such as variola virus, monkeypox virus and the vaccination strain vaccinia virus (VACV). Knowledge about the structural proteins that form the viral core has remained sparse. While major core proteins have been annotated via indirect experimental evidence, their structures have remained elusive and they could not be assigned to individual core features. Hence, which proteins constitute which layers of the core, such as the palisade layer and the inner core wall, has remained enigmatic. Here we show, using a multi-modal cryo-electron microscopy (cryo-EM) approach in combination with AlphaFold molecular modeling, that trimers formed by the cleavage product of VACV protein A10 are the key component of the palisade layer. This allows us to place previously obtained descriptions of protein interactions within the core wall into perspective and to provide a detailed model of poxvirus core architecture. Importantly, we show that interactions within A10 trimers are likely generalizable over members of orthopox- and parapoxviruses.","lang":"eng"}],"OA_type":"hybrid","page":"1114-1123","article_processing_charge":"Yes (in subscription journal)","date_created":"2024-02-12T09:59:45Z","date_published":"2024-07-01T00:00:00Z","OA_place":"publisher","status":"public","related_material":{"link":[{"description":"News on ISTA Website","url":"https://ista.ac.at/en/news/down-to-the-core-of-poxviruses/","relation":"press_release"}],"record":[{"id":"18766","status":"public","relation":"dissertation_contains"}]},"external_id":{"isi":["001158144600002"],"pmid":["38316877"]},"article_type":"original","publication_identifier":{"eissn":["1545-9985"],"issn":["1545-9993"]},"year":"2024","language":[{"iso":"eng"}],"publication":"Nature Structural & Molecular Biology","isi":1,"acknowledgement":"We thank A. Bergthaler (Research Center for Molecular Medicine of the Austrian Academy of Sciences) for providing VACV WR. We thank A. Nicholas and his team at the ISTA proteomics facility, and S. Elefante at the ISTA Scientific Computing facility for their support. We also thank F. Fäßler, D. Porley, T. Muthspiel and other members of the Schur group for support and helpful discussions. We also thank D. Castaño-Díez for support with Dynamo. We thank D. Farrell for his help optimizing the Rosetta protocol to refine the atomic model into the cryo-EM map with symmetry.\r\n\r\nF.K.M.S. acknowledges support from ISTA and EMBO. F.K.M.S. also received support from the Austrian Science Fund (FWF) grant P31445. This publication has been made possible in part by CZI grant DAF2021-234754 and grant https://doi.org/10.37921/812628ebpcwg from the Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation (funder https://doi.org/10.13039/100014989) awarded to F.K.M.S.\r\n\r\nThis research was also supported by the Scientific Service Units (SSUs) of ISTA through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), and the Electron Microscopy Facility (EMF). We also acknowledge the use of COSMIC45 and Colabfold46.","file_date_updated":"2024-07-22T11:27:22Z","quality_controlled":"1","author":[{"first_name":"Julia","id":"3B12E2E6-F248-11E8-B48F-1D18A9856A87","full_name":"Datler, Julia","orcid":"0000-0002-3616-8580","last_name":"Datler"},{"last_name":"Hansen","full_name":"Hansen, Jesse","orcid":"0000-0001-7967-2085","first_name":"Jesse","id":"1063c618-6f9b-11ec-9123-f912fccded63"},{"last_name":"Thader","first_name":"Andreas","id":"3A18A7B8-F248-11E8-B48F-1D18A9856A87","full_name":"Thader, Andreas"},{"last_name":"Schlögl","orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois","first_name":"Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Bauer, Lukas W","first_name":"Lukas W","id":"0c894dcf-897b-11ed-a09c-8186353224b0","last_name":"Bauer"},{"last_name":"Hodirnau","full_name":"Hodirnau, Victor-Valentin","orcid":"0000-0003-3904-947X","first_name":"Victor-Valentin","id":"3661B498-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Schur","full_name":"Schur, Florian KM","orcid":"0000-0003-4790-8078","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","first_name":"Florian KM"}],"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"LifeSc"},{"_id":"EM-Fac"}]},{"date_updated":"2024-07-16T10:17:09Z","_id":"13161","month":"07","title":"Running Windows-applications on a Linux HPC cluster using WINE","ddc":["000"],"corr_author":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference_abstract","has_accepted_license":"1","conference":{"start_date":"2023-06-13","end_date":"2023-06-15","name":"ASHPC: Austrian-Slovenian HPC Meeting","location":"Maribor, Slovenia"},"oa_version":"Submitted Version","day":"01","oa":1,"citation":{"ama":"Schlögl A, Elefante S, Hodirnau V-V. Running Windows-applications on a Linux HPC cluster using WINE. In: <i>ASHPC23 - Austrian-Slovenian HPC Meeting 2023</i>. EuroCC; 2023:59-59.","short":"A. Schlögl, S. Elefante, V.-V. Hodirnau, in:, ASHPC23 - Austrian-Slovenian HPC Meeting 2023, EuroCC, 2023, pp. 59–59.","chicago":"Schlögl, Alois, Stefano Elefante, and Victor-Valentin Hodirnau. “Running Windows-Applications on a Linux HPC Cluster Using WINE.” In <i>ASHPC23 - Austrian-Slovenian HPC Meeting 2023</i>, 59–59. EuroCC, 2023.","ista":"Schlögl A, Elefante S, Hodirnau V-V. 2023. Running Windows-applications on a Linux HPC cluster using WINE. ASHPC23 - Austrian-Slovenian HPC Meeting 2023. ASHPC: Austrian-Slovenian HPC Meeting, 59–59.","ieee":"A. Schlögl, S. Elefante, and V.-V. Hodirnau, “Running Windows-applications on a Linux HPC cluster using WINE,” in <i>ASHPC23 - Austrian-Slovenian HPC Meeting 2023</i>, Maribor, Slovenia, 2023, pp. 59–59.","apa":"Schlögl, A., Elefante, S., &#38; Hodirnau, V.-V. (2023). Running Windows-applications on a Linux HPC cluster using WINE. In <i>ASHPC23 - Austrian-Slovenian HPC Meeting 2023</i> (pp. 59–59). Maribor, Slovenia: EuroCC.","mla":"Schlögl, Alois, et al. “Running Windows-Applications on a Linux HPC Cluster Using WINE.” <i>ASHPC23 - Austrian-Slovenian HPC Meeting 2023</i>, EuroCC, 2023, pp. 59–59."},"publisher":"EuroCC","publication_status":"published","department":[{"_id":"ScienComp"},{"_id":"EM-Fac"}],"language":[{"iso":"eng"}],"publication":"ASHPC23 - Austrian-Slovenian HPC Meeting 2023","year":"2023","acknowledgement":"Thanks to Jesse Hansen for his suggestions on improving the abstract.","file_date_updated":"2023-07-18T09:18:55Z","author":[{"last_name":"Schlögl","orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois"},{"full_name":"Elefante, Stefano","first_name":"Stefano","id":"490F40CE-F248-11E8-B48F-1D18A9856A87","last_name":"Elefante"},{"full_name":"Hodirnau, Victor-Valentin","orcid":"0000-0003-3904-947X","id":"3661B498-F248-11E8-B48F-1D18A9856A87","first_name":"Victor-Valentin","last_name":"Hodirnau"}],"quality_controlled":"1","page":"59-59","file":[{"content_type":"application/pdf","success":1,"access_level":"open_access","creator":"dernst","file_id":"13249","date_updated":"2023-07-18T09:18:55Z","file_size":316959,"relation":"main_file","date_created":"2023-07-18T09:18:55Z","checksum":"ec8e4295d54171032cdd1b01423eb4a6","file_name":"2023_ASHPC_Schloegl.pdf"}],"status":"public","article_processing_charge":"No","date_published":"2023-07-01T00:00:00Z","date_created":"2023-06-23T11:01:23Z"},{"quality_controlled":"1","author":[{"full_name":"Elefante, Stefano","first_name":"Stefano","id":"490F40CE-F248-11E8-B48F-1D18A9856A87","last_name":"Elefante"},{"first_name":"Stephan","id":"4D0BC184-F248-11E8-B48F-1D18A9856A87","full_name":"Stadlbauer, Stephan","last_name":"Stadlbauer"},{"full_name":"Alexander, Michael F","first_name":"Michael F","id":"3A02A8FA-F248-11E8-B48F-1D18A9856A87","last_name":"Alexander"},{"last_name":"Schlögl","full_name":"Schlögl, Alois","orcid":"0000-0002-5621-8100","first_name":"Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87"}],"file_date_updated":"2023-07-18T09:28:30Z","publication":"ASHPC23 - Austrian-Slovenian HPC Meeting 2023","language":[{"iso":"eng"}],"year":"2023","article_processing_charge":"No","date_created":"2023-06-23T11:03:18Z","date_published":"2023-07-01T00:00:00Z","status":"public","file":[{"content_type":"application/pdf","creator":"dernst","access_level":"open_access","success":1,"file_id":"13250","file_size":380354,"date_updated":"2023-07-18T09:28:30Z","relation":"main_file","date_created":"2023-07-18T09:28:30Z","file_name":"2023_ASHPC_Elefante.pdf","checksum":"0ab6173cd5c5634ed773cd37ff012681"}],"page":"42-42","type":"conference_abstract","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"corr_author":"1","title":"Cryo-EM software packages: A sys-admins point of view","ddc":["000"],"month":"07","date_updated":"2024-07-16T10:24:07Z","_id":"13162","publication_status":"published","department":[{"_id":"ScienComp"}],"publisher":"EuroCC","oa":1,"citation":{"ama":"Elefante S, Stadlbauer S, Alexander MF, Schlögl A. Cryo-EM software packages: A sys-admins point of view. In: <i>ASHPC23 - Austrian-Slovenian HPC Meeting 2023</i>. EuroCC; 2023:42-42.","short":"S. Elefante, S. Stadlbauer, M.F. Alexander, A. Schlögl, in:, ASHPC23 - Austrian-Slovenian HPC Meeting 2023, EuroCC, 2023, pp. 42–42.","chicago":"Elefante, Stefano, Stephan Stadlbauer, Michael F Alexander, and Alois Schlögl. “Cryo-EM Software Packages: A Sys-Admins Point of View.” In <i>ASHPC23 - Austrian-Slovenian HPC Meeting 2023</i>, 42–42. EuroCC, 2023.","mla":"Elefante, Stefano, et al. “Cryo-EM Software Packages: A Sys-Admins Point of View.” <i>ASHPC23 - Austrian-Slovenian HPC Meeting 2023</i>, EuroCC, 2023, pp. 42–42.","ieee":"S. Elefante, S. Stadlbauer, M. F. Alexander, and A. Schlögl, “Cryo-EM software packages: A sys-admins point of view,” in <i>ASHPC23 - Austrian-Slovenian HPC Meeting 2023</i>, Maribor, Slovenia, 2023, pp. 42–42.","ista":"Elefante S, Stadlbauer S, Alexander MF, Schlögl A. 2023. Cryo-EM software packages: A sys-admins point of view. ASHPC23 - Austrian-Slovenian HPC Meeting 2023. ASHPC: Austrian-Slovenian HPC Meeting, 42–42.","apa":"Elefante, S., Stadlbauer, S., Alexander, M. F., &#38; Schlögl, A. (2023). Cryo-EM software packages: A sys-admins point of view. In <i>ASHPC23 - Austrian-Slovenian HPC Meeting 2023</i> (pp. 42–42). Maribor, Slovenia: EuroCC."},"oa_version":"Submitted Version","day":"01","conference":{"name":"ASHPC: Austrian-Slovenian HPC Meeting","location":"Maribor, Slovenia","start_date":"2023-06-12","end_date":"2023-06-15"},"has_accepted_license":"1"},{"status":"public","date_published":"2022-06-02T00:00:00Z","date_created":"2023-05-05T09:13:42Z","article_processing_charge":"No","page":"7","file":[{"file_size":7180531,"date_updated":"2023-05-05T09:06:00Z","file_id":"12895","access_level":"open_access","creator":"schloegl","success":1,"content_type":"application/pdf","file_name":"BOOKLET_ASHPC22.pdf","checksum":"e3f8c240b85422ce2190e7b203cc2563","date_created":"2023-05-05T09:06:00Z","relation":"main_file"}],"author":[{"last_name":"Schlögl","full_name":"Schlögl, Alois","orcid":"0000-0002-5621-8100","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois"},{"last_name":"Hornoiu","full_name":"Hornoiu, Andrei","id":"77129392-B450-11EA-8745-D4653DDC885E","first_name":"Andrei"},{"full_name":"Elefante, Stefano","id":"490F40CE-F248-11E8-B48F-1D18A9856A87","first_name":"Stefano","last_name":"Elefante"},{"full_name":"Stadlbauer, Stephan","first_name":"Stephan","id":"4D0BC184-F248-11E8-B48F-1D18A9856A87","last_name":"Stadlbauer"}],"year":"2022","language":[{"iso":"eng"}],"publication":"ASHPC22 - Austrian-Slovenian HPC Meeting 2022","publication_identifier":{"isbn":["978-3-200-08499-5"]},"file_date_updated":"2023-05-05T09:06:00Z","acknowledgement":"The abstracts in this booklet are licenced under a CC BY 4.0 licence (https://creativecommons.org/licenses/by/4.0/legalcode), except Markus Wallerberger’s contribution at page 21, licenced under a CC BY-SA 4.0 licence (https://creativecommons.org/licenses/by-sa/4.0/legalcode).\r\n","citation":{"ista":"Schlögl A, Hornoiu A, Elefante S, Stadlbauer S. 2022. Where is the sweet spot? A procurement story of general purpose compute nodes. ASHPC22 - Austrian-Slovenian HPC Meeting 2022. ASHPC: Austrian-Slovenian HPC Meeting, 7.","apa":"Schlögl, A., Hornoiu, A., Elefante, S., &#38; Stadlbauer, S. (2022). Where is the sweet spot? A procurement story of general purpose compute nodes. In <i>ASHPC22 - Austrian-Slovenian HPC Meeting 2022</i> (p. 7). Grundlsee, Austria: EuroCC Austria c/o Universität Wien. <a href=\"https://doi.org/10.25365/phaidra.337\">https://doi.org/10.25365/phaidra.337</a>","ieee":"A. Schlögl, A. Hornoiu, S. Elefante, and S. Stadlbauer, “Where is the sweet spot? A procurement story of general purpose compute nodes,” in <i>ASHPC22 - Austrian-Slovenian HPC Meeting 2022</i>, Grundlsee, Austria, 2022, p. 7.","mla":"Schlögl, Alois, et al. “Where Is the Sweet Spot? A Procurement Story of General Purpose Compute Nodes.” <i>ASHPC22 - Austrian-Slovenian HPC Meeting 2022</i>, EuroCC Austria c/o Universität Wien, 2022, p. 7, doi:<a href=\"https://doi.org/10.25365/phaidra.337\">10.25365/phaidra.337</a>.","chicago":"Schlögl, Alois, Andrei Hornoiu, Stefano Elefante, and Stephan Stadlbauer. “Where Is the Sweet Spot? A Procurement Story of General Purpose Compute Nodes.” In <i>ASHPC22 - Austrian-Slovenian HPC Meeting 2022</i>, 7. EuroCC Austria c/o Universität Wien, 2022. <a href=\"https://doi.org/10.25365/phaidra.337\">https://doi.org/10.25365/phaidra.337</a>.","short":"A. Schlögl, A. Hornoiu, S. Elefante, S. Stadlbauer, in:, ASHPC22 - Austrian-Slovenian HPC Meeting 2022, EuroCC Austria c/o Universität Wien, 2022, p. 7.","ama":"Schlögl A, Hornoiu A, Elefante S, Stadlbauer S. Where is the sweet spot? A procurement story of general purpose compute nodes. In: <i>ASHPC22 - Austrian-Slovenian HPC Meeting 2022</i>. EuroCC Austria c/o Universität Wien; 2022:7. doi:<a href=\"https://doi.org/10.25365/phaidra.337\">10.25365/phaidra.337</a>"},"oa":1,"publisher":"EuroCC Austria c/o Universität Wien","department":[{"_id":"ScienComp"}],"publication_status":"published","has_accepted_license":"1","conference":{"name":"ASHPC: Austrian-Slovenian HPC Meeting","location":"Grundlsee, Austria","start_date":"2022-05-31","end_date":"2022-06-02"},"doi":"10.25365/phaidra.337","day":"02","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference_abstract","_id":"12894","date_updated":"2024-10-09T21:05:24Z","month":"06","title":"Where is the sweet spot? A procurement story of general purpose compute nodes","ddc":["000"],"corr_author":"1"},{"article_type":"review","article_processing_charge":"Yes","date_published":"2021-08-24T00:00:00Z","date_created":"2024-04-03T09:03:31Z","status":"public","file":[{"date_updated":"2024-04-09T06:49:47Z","file_size":3539897,"file_id":"15302","success":1,"creator":"dernst","access_level":"open_access","content_type":"application/pdf","checksum":"f67142b1e1e8ca5cd7a6a6798f46375e","file_name":"2021_Hearts_Rubel.pdf","date_created":"2024-04-09T06:49:47Z","relation":"main_file"}],"abstract":[{"text":"Ever since the first publication of the standard communication protocol for computer-assisted electrocardiography (SCP-ECG), prENV 1064, in 1993, by the European Committee for Standardization (CEN), SCP-ECG has become a leading example in health informatics, enabling open, secure, and well-documented digital data exchange at a low cost, for quick and efficient cardiovascular disease detection and management. Based on the experiences gained, since the 1970s, in computerized electrocardiology, and on the results achieved by the pioneering, international cooperative research on common standards for quantitative electrocardiography (CSE), SCP-ECG was designed, from the beginning, to empower personalized medicine, thanks to serial ECG analysis. The fundamental concept behind SCP-ECG is to convey the necessary information for ECG re-analysis, serial comparison, and interpretation, and to structure the ECG data and metadata in sections that are mostly optional in order to fit all use cases. SCP-ECG is open to the storage of the ECG signal and ECG measurement data, whatever the ECG recording modality or computation method, and can store the over-reading trails and ECG annotations, as well as any computerized or medical interpretation reports. Only the encoding syntax and the semantics of the ECG descriptors and of the diagnosis codes are standardized. We present all of the landmarks in the development and publication of SCP-ECG, from the early 1990s to the 2009 International Organization for Standardization (ISO) SCP-ECG standards, including the latest version published by CEN in 2020, which now encompasses rest and stress ECGs, Holter recordings, and protocol-based trials.","lang":"eng"}],"page":"384-409","quality_controlled":"1","issue":"3","author":[{"last_name":"Rubel","first_name":"Paul","full_name":"Rubel, Paul"},{"last_name":"Fayn","full_name":"Fayn, Jocelyne","first_name":"Jocelyne"},{"first_name":"Peter W.","full_name":"Macfarlane, Peter W.","last_name":"Macfarlane"},{"last_name":"Pani","first_name":"Danilo","full_name":"Pani, Danilo"},{"orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","last_name":"Schlögl"},{"last_name":"Värri","full_name":"Värri, Alpo","first_name":"Alpo"}],"acknowledgement":"This research received no external funding. The authors thank the large number of researchers, engineers, cardiologists, and clinicians from academia, industry, and normalization organizations who contributed to the development and testing of the SCP-ECG standards.","file_date_updated":"2024-04-09T06:49:47Z","publication_identifier":{"issn":["2673-3846"]},"year":"2021","publication":"Hearts","language":[{"iso":"eng"}],"keyword":["General Medicine"],"intvolume":"         2","publication_status":"published","department":[{"_id":"ScienComp"}],"publisher":"MDPI","oa":1,"citation":{"chicago":"Rubel, Paul, Jocelyne Fayn, Peter W. Macfarlane, Danilo Pani, Alois Schlögl, and Alpo Värri. “The History and Challenges of SCP-ECG: The Standard Communication Protocol for Computer-Assisted Electrocardiography.” <i>Hearts</i>. MDPI, 2021. <a href=\"https://doi.org/10.3390/hearts2030031\">https://doi.org/10.3390/hearts2030031</a>.","ama":"Rubel P, Fayn J, Macfarlane PW, Pani D, Schlögl A, Värri A. The history and challenges of SCP-ECG: The standard communication protocol for computer-assisted electrocardiography. <i>Hearts</i>. 2021;2(3):384-409. doi:<a href=\"https://doi.org/10.3390/hearts2030031\">10.3390/hearts2030031</a>","short":"P. Rubel, J. Fayn, P.W. Macfarlane, D. Pani, A. Schlögl, A. Värri, Hearts 2 (2021) 384–409.","ista":"Rubel P, Fayn J, Macfarlane PW, Pani D, Schlögl A, Värri A. 2021. The history and challenges of SCP-ECG: The standard communication protocol for computer-assisted electrocardiography. Hearts. 2(3), 384–409.","apa":"Rubel, P., Fayn, J., Macfarlane, P. W., Pani, D., Schlögl, A., &#38; Värri, A. (2021). The history and challenges of SCP-ECG: The standard communication protocol for computer-assisted electrocardiography. <i>Hearts</i>. MDPI. <a href=\"https://doi.org/10.3390/hearts2030031\">https://doi.org/10.3390/hearts2030031</a>","ieee":"P. Rubel, J. Fayn, P. W. Macfarlane, D. Pani, A. Schlögl, and A. Värri, “The history and challenges of SCP-ECG: The standard communication protocol for computer-assisted electrocardiography,” <i>Hearts</i>, vol. 2, no. 3. MDPI, pp. 384–409, 2021.","mla":"Rubel, Paul, et al. “The History and Challenges of SCP-ECG: The Standard Communication Protocol for Computer-Assisted Electrocardiography.” <i>Hearts</i>, vol. 2, no. 3, MDPI, 2021, pp. 384–409, doi:<a href=\"https://doi.org/10.3390/hearts2030031\">10.3390/hearts2030031</a>."},"oa_version":"Published Version","day":"24","doi":"10.3390/hearts2030031","has_accepted_license":"1","volume":2,"type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["610"],"title":"The history and challenges of SCP-ECG: The standard communication protocol for computer-assisted electrocardiography","month":"08","date_updated":"2024-04-09T06:51:50Z","_id":"15285"},{"date_updated":"2025-06-12T06:39:15Z","_id":"9329","month":"03","title":"MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo","ddc":["570"],"tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"type":"journal_article","ec_funded":1,"scopus_import":"1","has_accepted_license":"1","volume":357,"project":[{"call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","grant_number":"692692","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse"},{"grant_number":"Z00312","name":"Synaptic communication in neuronal microcircuits","_id":"25C5A090-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"day":"09","oa_version":"Published Version","doi":"10.1016/j.jneumeth.2021.109125","oa":1,"citation":{"mla":"Zhang, Xiaomin, et al. “MOD: A Novel Machine-Learning Optimal-Filtering Method for Accurate and Efficient Detection of Subthreshold Synaptic Events in Vivo.” <i>Journal of Neuroscience Methods</i>, vol. 357, no. 6, 109125, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">10.1016/j.jneumeth.2021.109125</a>.","apa":"Zhang, X., Schlögl, A., Vandael, D. H., &#38; Jonas, P. M. (2021). MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo. <i>Journal of Neuroscience Methods</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">https://doi.org/10.1016/j.jneumeth.2021.109125</a>","ieee":"X. Zhang, A. Schlögl, D. H. Vandael, and P. M. Jonas, “MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo,” <i>Journal of Neuroscience Methods</i>, vol. 357, no. 6. Elsevier, 2021.","ista":"Zhang X, Schlögl A, Vandael DH, Jonas PM. 2021. MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo. Journal of Neuroscience Methods. 357(6), 109125.","ama":"Zhang X, Schlögl A, Vandael DH, Jonas PM. MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo. <i>Journal of Neuroscience Methods</i>. 2021;357(6). doi:<a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">10.1016/j.jneumeth.2021.109125</a>","short":"X. Zhang, A. Schlögl, D.H. Vandael, P.M. Jonas, Journal of Neuroscience Methods 357 (2021).","chicago":"Zhang, Xiaomin, Alois Schlögl, David H Vandael, and Peter M Jonas. “MOD: A Novel Machine-Learning Optimal-Filtering Method for Accurate and Efficient Detection of Subthreshold Synaptic Events in Vivo.” <i>Journal of Neuroscience Methods</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">https://doi.org/10.1016/j.jneumeth.2021.109125</a>."},"publisher":"Elsevier","publication_status":"published","department":[{"_id":"PeJo"},{"_id":"ScienComp"}],"intvolume":"       357","isi":1,"language":[{"iso":"eng"}],"year":"2021","publication":"Journal of Neuroscience Methods","publication_identifier":{"issn":["0165-0270"],"eissn":["1872-678X"]},"file_date_updated":"2021-04-19T08:30:22Z","acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement number 692692 to P.J.) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award to P.J.). We thank Drs. Jozsef Csicsvari, Christoph Lampert, and Federico Stella for critically reading previous manuscript versions. We are also grateful to Drs. Josh Merel and Ben Shababo for their help with applying the Bayesian detection method to our data. We also thank Florian Marr for technical assistance, Eleftheria Kralli-Beller for manuscript editing, and the Scientific Service Units of IST Austria for efficient support.","article_number":"109125","author":[{"first_name":"Xiaomin","id":"423EC9C2-F248-11E8-B48F-1D18A9856A87","full_name":"Zhang, Xiaomin","last_name":"Zhang"},{"last_name":"Schlögl","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois"},{"last_name":"Vandael","full_name":"Vandael, David H","orcid":"0000-0001-7577-1676","first_name":"David H","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Jonas","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804"}],"issue":"6","quality_controlled":"1","acknowledged_ssus":[{"_id":"SSU"}],"abstract":[{"lang":"eng","text":"Background: To understand information coding in single neurons, it is necessary to analyze subthreshold synaptic events, action potentials (APs), and their interrelation in different behavioral states. However, detecting excitatory postsynaptic potentials (EPSPs) or currents (EPSCs) in behaving animals remains challenging, because of unfavorable signal-to-noise ratio, high frequency, fluctuating amplitude, and variable time course of synaptic events.\r\nNew method: We developed a method for synaptic event detection, termed MOD (Machine-learning Optimal-filtering Detection-procedure), which combines concepts of supervised machine learning and optimal Wiener filtering. Experts were asked to manually score short epochs of data. The algorithm was trained to obtain the optimal filter coefficients of a Wiener filter and the optimal detection threshold. Scored and unscored data were then processed with the optimal filter, and events were detected as peaks above threshold.\r\nResults: We challenged MOD with EPSP traces in vivo in mice during spatial navigation and EPSC traces in vitro in slices under conditions of enhanced transmitter release. The area under the curve (AUC) of the receiver operating characteristics (ROC) curve was, on average, 0.894 for in vivo and 0.969 for in vitro data sets, indicating high detection accuracy and efficiency.\r\nComparison with existing methods: When benchmarked using a (1 − AUC)−1 metric, MOD outperformed previous methods (template-fit, deconvolution, and Bayesian methods) by an average factor of 3.13 for in vivo data sets, but showed comparable (template-fit, deconvolution) or higher (Bayesian) computational efficacy.\r\nConclusions: MOD may become an important new tool for large-scale, real-time analysis of synaptic activity."}],"file":[{"file_size":6924738,"date_updated":"2021-04-19T08:30:22Z","file_id":"9339","access_level":"open_access","creator":"dernst","success":1,"content_type":"application/pdf","file_name":"2021_JourNeuroscienceMeth_Zhang.pdf","checksum":"2a5800d91b96d08b525e17319dcd5e44","date_created":"2021-04-19T08:30:22Z","relation":"main_file"}],"status":"public","article_processing_charge":"Yes (via OA deal)","date_published":"2021-03-09T00:00:00Z","date_created":"2021-04-18T22:01:39Z","external_id":{"isi":["000661088500005"],"pmid":["33711356"]},"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","article_type":"original"},{"article_processing_charge":"No","date_published":"2021-06-02T00:00:00Z","date_created":"2023-05-05T13:17:36Z","status":"public","file":[{"file_id":"12971","date_updated":"2023-05-16T07:36:34Z","file_size":422761,"content_type":"application/pdf","success":1,"creator":"dernst","access_level":"open_access","date_created":"2023-05-16T07:36:34Z","checksum":"ba73f85858fb9d5737ebc7724646dd45","file_name":"2021_ASHPC_Schloegl.pdf","relation":"main_file"}],"page":"5","author":[{"full_name":"Schlögl, Alois","orcid":"0000-0002-5621-8100","first_name":"Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","last_name":"Schlögl"},{"full_name":"Elefante, Stefano","first_name":"Stefano","id":"490F40CE-F248-11E8-B48F-1D18A9856A87","last_name":"Elefante"},{"last_name":"Hornoiu","full_name":"Hornoiu, Andrei","first_name":"Andrei","id":"77129392-B450-11EA-8745-D4653DDC885E"},{"full_name":"Stadlbauer, Stephan","id":"4D0BC184-F248-11E8-B48F-1D18A9856A87","first_name":"Stephan","last_name":"Stadlbauer"}],"file_date_updated":"2023-05-16T07:36:34Z","publication_identifier":{"isbn":["978-961-6980-77-7","978-961-6133-48-7"]},"year":"2021","language":[{"iso":"eng"}],"publication":"ASHPC21 – Austrian-Slovenian HPC Meeting 2021","publication_status":"published","department":[{"_id":"ScienComp"}],"publisher":"University of Ljubljana","oa":1,"citation":{"chicago":"Schlögl, Alois, Stefano Elefante, Andrei Hornoiu, and Stephan Stadlbauer. “Managing Software on a Heterogenous HPC Cluster.” In <i>ASHPC21 – Austrian-Slovenian HPC Meeting 2021</i>, 5. University of Ljubljana, 2021. <a href=\"https://doi.org/10.3359/2021hpc\">https://doi.org/10.3359/2021hpc</a>.","short":"A. Schlögl, S. Elefante, A. Hornoiu, S. Stadlbauer, in:, ASHPC21 – Austrian-Slovenian HPC Meeting 2021, University of Ljubljana, 2021, p. 5.","ama":"Schlögl A, Elefante S, Hornoiu A, Stadlbauer S. Managing software on a heterogenous HPC cluster. In: <i>ASHPC21 – Austrian-Slovenian HPC Meeting 2021</i>. University of Ljubljana; 2021:5. doi:<a href=\"https://doi.org/10.3359/2021hpc\">10.3359/2021hpc</a>","mla":"Schlögl, Alois, et al. “Managing Software on a Heterogenous HPC Cluster.” <i>ASHPC21 – Austrian-Slovenian HPC Meeting 2021</i>, University of Ljubljana, 2021, p. 5, doi:<a href=\"https://doi.org/10.3359/2021hpc\">10.3359/2021hpc</a>.","ieee":"A. Schlögl, S. Elefante, A. Hornoiu, and S. Stadlbauer, “Managing software on a heterogenous HPC cluster,” in <i>ASHPC21 – Austrian-Slovenian HPC Meeting 2021</i>, Virtual, 2021, p. 5.","apa":"Schlögl, A., Elefante, S., Hornoiu, A., &#38; Stadlbauer, S. (2021). Managing software on a heterogenous HPC cluster. In <i>ASHPC21 – Austrian-Slovenian HPC Meeting 2021</i> (p. 5). Virtual: University of Ljubljana. <a href=\"https://doi.org/10.3359/2021hpc\">https://doi.org/10.3359/2021hpc</a>","ista":"Schlögl A, Elefante S, Hornoiu A, Stadlbauer S. 2021. Managing software on a heterogenous HPC cluster. ASHPC21 – Austrian-Slovenian HPC Meeting 2021. ASHPC: Austrian-Slovenian HPC Meeting, 5."},"oa_version":"Published Version","day":"02","main_file_link":[{"url":"https://vsc.ac.at/fileadmin/user_upload/vsc/conferences/ashpc21/BOOKLET_ASHPC21.pdf","open_access":"1"}],"doi":"10.3359/2021hpc","conference":{"end_date":"2021-06-02","start_date":"2021-05-31","location":"Virtual","name":"ASHPC: Austrian-Slovenian HPC Meeting"},"has_accepted_license":"1","type":"conference_abstract","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","corr_author":"1","title":"Managing software on a heterogenous HPC cluster","ddc":["000"],"month":"06","date_updated":"2026-04-16T10:19:31Z","_id":"12909"},{"isi":1,"publication":"Nature Computational Science","year":"2021","language":[{"iso":"eng"}],"publication_identifier":{"issn":["2662-8457"]},"acknowledgement":"We thank A. Aertsen, N. Kopell, W. Maass, A. Roth, F. Stella and T. Vogels for critically reading earlier versions of the manuscript. We are grateful to F. Marr and C. Altmutter for excellent technical assistance, E. Kralli-Beller for manuscript editing, and the Scientific Service Units of IST Austria for efficient support. Finally, we thank T. Carnevale, L. Erdös, M. Hines, D. Nykamp and D. Schröder for useful discussions, and R. Friedrich and S. Wiechert for sharing unpublished data. This project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 692692, P.J.) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award to P.J. and P 31815 to S.J.G.).","file_date_updated":"2022-06-18T22:30:03Z","author":[{"orcid":"0000-0003-2209-5242","full_name":"Guzmán, José","first_name":"José","id":"30CC5506-F248-11E8-B48F-1D18A9856A87","last_name":"Guzmán"},{"last_name":"Schlögl","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois"},{"last_name":"Espinoza Martinez","first_name":"Claudia ","id":"31FFEE2E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4710-2082","full_name":"Espinoza Martinez, Claudia "},{"last_name":"Zhang","id":"423EC9C2-F248-11E8-B48F-1D18A9856A87","first_name":"Xiaomin","orcid":"0000-0003-0256-6529","full_name":"Zhang, Xiaomin"},{"last_name":"Suter","id":"4952F31E-F248-11E8-B48F-1D18A9856A87","first_name":"Benjamin","orcid":"0000-0002-9885-6936","full_name":"Suter, Benjamin"},{"last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M"}],"issue":"12","quality_controlled":"1","acknowledged_ssus":[{"_id":"SSU"}],"abstract":[{"lang":"eng","text":"Pattern separation is a fundamental brain computation that converts small differences in input patterns into large differences in output patterns. Several synaptic mechanisms of pattern separation have been proposed, including code expansion, inhibition and plasticity; however, which of these mechanisms play a role in the entorhinal cortex (EC)–dentate gyrus (DG)–CA3 circuit, a classical pattern separation circuit, remains unclear. Here we show that a biologically realistic, full-scale EC–DG–CA3 circuit model, including granule cells (GCs) and parvalbumin-positive inhibitory interneurons (PV+-INs) in the DG, is an efficient pattern separator. Both external gamma-modulated inhibition and internal lateral inhibition mediated by PV+-INs substantially contributed to pattern separation. Both local connectivity and fast signaling at GC–PV+-IN synapses were important for maximum effectiveness. Similarly, mossy fiber synapses with conditional detonator properties contributed to pattern separation. By contrast, perforant path synapses with Hebbian synaptic plasticity and direct EC–CA3 connection shifted the network towards pattern completion. Our results demonstrate that the specific properties of cells and synapses optimize higher-order computations in biological networks and might be useful to improve the deep learning capabilities of technical networks."}],"page":"830-842","file":[{"file_size":1699466,"date_updated":"2022-06-18T22:30:03Z","file_id":"11430","creator":"patrickd","access_level":"open_access","content_type":"application/pdf","file_name":"Guzmanetal2021.pdf","checksum":"9fec5b667909ef52be96d502e4f8c2ae","date_created":"2022-06-02T12:51:07Z","embargo":"2022-06-17","relation":"main_file"},{"date_created":"2022-06-02T12:53:47Z","checksum":"52a005b13a114e3c3a28fa6bbe8b1a8d","file_name":"Guzmanetal2021Suppl.pdf","relation":"supplementary_material","embargo":"2022-06-17","file_id":"11431","date_updated":"2022-06-18T22:30:03Z","file_size":3005651,"content_type":"application/pdf","title":"Supplementary Material","access_level":"open_access","creator":"patrickd"}],"status":"public","article_processing_charge":"No","date_created":"2022-03-04T08:32:36Z","date_published":"2021-12-16T00:00:00Z","external_id":{"isi":["000888567500015"]},"article_type":"original","related_material":{"record":[{"id":"10110","status":"public","relation":"software"}],"link":[{"relation":"press_release","url":"https://ista.ac.at/en/news/spot-the-difference/"}]},"date_updated":"2025-10-09T22:30:54Z","_id":"10816","month":"12","ddc":["610"],"title":"How connectivity rules and synaptic properties shape the efficacy of pattern separation in the entorhinal cortex–dentate gyrus–CA3 network","corr_author":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","type":"journal_article","ec_funded":1,"volume":1,"scopus_import":"1","has_accepted_license":"1","project":[{"call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","grant_number":"692692","name":"Biophysics and circuit function of a giant cortical glutamatergic synapse"},{"call_identifier":"FWF","_id":"25C5A090-B435-11E9-9278-68D0E5697425","grant_number":"Z00312","name":"Synaptic communication in neuronal microcircuits"}],"oa_version":"Submitted Version","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/647800","open_access":"1"}],"day":"16","doi":"10.1038/s43588-021-00157-1","oa":1,"citation":{"ieee":"J. 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How connectivity rules and synaptic properties shape the efficacy of pattern separation in the entorhinal cortex–dentate gyrus–CA3 network. <i>Nature Computational Science</i>. 2021;1(12):830-842. doi:<a href=\"https://doi.org/10.1038/s43588-021-00157-1\">10.1038/s43588-021-00157-1</a>","short":"J. Guzmán, A. Schlögl, C. Espinoza Martinez, X. Zhang, B. Suter, P.M. Jonas, Nature Computational Science 1 (2021) 830–842."},"publisher":"Springer Nature","publication_status":"published","department":[{"_id":"PeJo"}],"keyword":["general medicine"],"intvolume":"         1"},{"has_accepted_license":"1","abstract":[{"lang":"eng","text":"Pattern separation is a fundamental brain computation that converts small differences in input patterns into large differences in output patterns. Several synaptic mechanisms of pattern separation have been proposed, including code expansion, inhibition and plasticity; however, which of these mechanisms play a role in the entorhinal cortex (EC)–dentate gyrus (DG)–CA3 circuit, a classical pattern separation circuit, remains unclear. Here we show that a biologically realistic, full-scale EC–DG–CA3 circuit model, including granule cells (GCs) and parvalbumin-positive inhibitory interneurons (PV+-INs) in the DG, is an efficient pattern separator. Both external gamma-modulated inhibition and internal lateral inhibition mediated by PV+-INs substantially contributed to pattern separation. Both local connectivity and fast signaling at GC–PV+-IN synapses were important for maximum effectiveness. Similarly, mossy fiber synapses with conditional detonator properties contributed to pattern separation. By contrast, perforant path synapses with Hebbian synaptic plasticity and direct EC–CA3 connection shifted the network towards pattern completion. Our results demonstrate that the specific properties of cells and synapses optimize higher-order computations in biological networks and might be useful to improve the deep learning capabilities of technical networks."}],"file":[{"checksum":"f92f8931cad0aa7e411c1715337bf408","file_name":"patternseparation-main (1).zip","date_created":"2021-10-08T08:46:04Z","relation":"main_file","date_updated":"2021-10-08T08:46:04Z","file_size":332990101,"file_id":"10114","success":1,"access_level":"open_access","creator":"cchlebak","content_type":"application/x-zip-compressed"}],"doi":"10.15479/AT:ISTA:10110","day":"16","citation":{"mla":"Guzmán, José, et al. <i>How Connectivity Rules and Synaptic Properties Shape the Efficacy of Pattern Separation in the Entorhinal Cortex–Dentate Gyrus–CA3 Network</i>. 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We thank Gyorgy Buzsáki, Jozsef Csicsvari, Juan Ramirez Villegas, and Federico Stella for commenting on earlier versions of this manuscript. We also thank Katie Bittner, Michael Brecht, Albert Lee, Jeffery Magee, and Alejandro Pernía-Andrade for sharing expertise in in vivo patch-clamp recording. We are grateful to Florian Marr for cell labeling, cell reconstruction, and technical assistance; Ben Suter for helpful discussions; Christina Altmutter for technical support; Eleftheria Kralli-Beller for manuscript editing; and Todor Asenov (Machine Shop) for device construction. We also thank the Scientific Service Units (SSUs) of IST Austria (Machine Shop, Scientific Computing, and Preclinical Facility) for efficient support.","file_date_updated":"2020-12-04T09:29:21Z","publication_identifier":{"issn":["0896-6273"]},"year":"2020","language":[{"iso":"eng"}],"publication":"Neuron","isi":1,"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"ScienComp"},{"_id":"PreCl"}],"quality_controlled":"1","author":[{"first_name":"Xiaomin","id":"423EC9C2-F248-11E8-B48F-1D18A9856A87","full_name":"Zhang, Xiaomin","last_name":"Zhang"},{"first_name":"Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois","last_name":"Schlögl"},{"last_name":"Jonas","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M"}],"issue":"6","file":[{"content_type":"application/pdf","success":1,"access_level":"open_access","creator":"dernst","file_id":"8920","date_updated":"2020-12-04T09:29:21Z","file_size":3011120,"relation":"main_file","date_created":"2020-12-04T09:29:21Z","checksum":"44a5960fc083a4cb3488d22224859fdc","file_name":"2020_Neuron_Zhang.pdf"}],"page":"1212-1225","abstract":[{"lang":"eng","text":"Dentate gyrus granule cells (GCs) connect the entorhinal cortex to the hippocampal CA3 region, but how they process spatial information remains enigmatic. To examine the role of GCs in spatial coding, we measured excitatory postsynaptic potentials (EPSPs) and action potentials (APs) in head-fixed mice running on a linear belt. Intracellular recording from morphologically identified GCs revealed that most cells were active, but activity level varied over a wide range. Whereas only ∼5% of GCs showed spatially tuned spiking, ∼50% received spatially tuned input. Thus, the GC population broadly encodes spatial information, but only a subset relays this information to the CA3 network. Fourier analysis indicated that GCs received conjunctive place-grid-like synaptic input, suggesting code conversion in single neurons. GC firing was correlated with dendritic complexity and intrinsic excitability, but not extrinsic excitatory input or dendritic cable properties. 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Klosterneuburg, Austria: IST Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:7474\">https://doi.org/10.15479/AT:ISTA:7474</a>."},"oa":1,"publisher":"IST Austria","doi":"10.15479/AT:ISTA:7474","oa_version":"Published Version","day":"19","has_accepted_license":"1","conference":{"name":"AHPC: Austrian High-Performance-Computing Meeting","location":"Klosterneuburg, Austria","start_date":"2020-02-19","end_date":"2020-02-21"}},{"publication_status":"published","department":[{"_id":"ScienComp"}],"oa":1,"citation":{"short":"A. Schlögl, J. Kiss, S. Elefante, in:, AHPC19 - Austrian HPC Meeting 2019 , Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz, 2019, p. 25.","ama":"Schlögl A, Kiss J, Elefante S. Is Debian suitable for running an HPC Cluster? In: <i>AHPC19 - Austrian HPC Meeting 2019 </i>. Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz; 2019:25.","chicago":"Schlögl, Alois, Janos Kiss, and Stefano Elefante. “Is Debian Suitable for Running an HPC Cluster?” In <i>AHPC19 - Austrian HPC Meeting 2019 </i>, 25. Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz, 2019.","apa":"Schlögl, A., Kiss, J., &#38; Elefante, S. (2019). Is Debian suitable for running an HPC Cluster? In <i>AHPC19 - Austrian HPC Meeting 2019 </i> (p. 25). Grundlsee, Austria: Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz.","ista":"Schlögl A, Kiss J, Elefante S. 2019. Is Debian suitable for running an HPC Cluster? AHPC19 - Austrian HPC Meeting 2019 . AHPC: Austrian HPC Meeting, 25.","ieee":"A. Schlögl, J. Kiss, and S. Elefante, “Is Debian suitable for running an HPC Cluster?,” in <i>AHPC19 - Austrian HPC Meeting 2019 </i>, Grundlsee, Austria, 2019, p. 25.","mla":"Schlögl, Alois, et al. “Is Debian Suitable for Running an HPC Cluster?” <i>AHPC19 - Austrian HPC Meeting 2019 </i>, Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz, 2019, p. 25."},"status":"public","publisher":"Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz","article_processing_charge":"No","date_created":"2023-05-05T12:48:48Z","date_published":"2019-02-27T00:00:00Z","main_file_link":[{"url":"https://vsc.ac.at/fileadmin/user_upload/vsc/conferences/ahpc19/BOOKLET_AHPC19.pdf","open_access":"1"}],"oa_version":"Published Version","day":"27","page":"25","has_accepted_license":"1","file":[{"relation":"main_file","checksum":"acc8272027faaf30709c51ac5c58ffa4","file_name":"2019_AHPC_Schloegl.pdf","date_created":"2023-05-16T07:27:09Z","access_level":"open_access","creator":"dernst","success":1,"content_type":"application/pdf","file_size":1097603,"date_updated":"2023-05-16T07:27:09Z","file_id":"12970"}],"conference":{"location":"Grundlsee, Austria","name":"AHPC: Austrian HPC Meeting","start_date":"2019-02-25","end_date":"2019-02-27"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Schlögl","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois"},{"last_name":"Kiss","full_name":"Kiss, Janos","id":"3D3A06F8-F248-11E8-B48F-1D18A9856A87","first_name":"Janos"},{"last_name":"Elefante","first_name":"Stefano","id":"490F40CE-F248-11E8-B48F-1D18A9856A87","full_name":"Elefante, Stefano"}],"type":"conference_abstract","file_date_updated":"2023-05-16T07:27:09Z","ddc":["000"],"title":"Is Debian suitable for running an HPC Cluster?","corr_author":"1","date_updated":"2024-10-09T21:05:24Z","_id":"12901","language":[{"iso":"eng"}],"publication":"AHPC19 - Austrian HPC Meeting 2019 ","year":"2019","month":"02"},{"status":"public","citation":{"apa":"Schlögl, A., &#38; Kiss, J. (2017). Scientific Computing at IST Austria. In <i>AHPC17 – Austrian HPC Meeting 2017</i> (p. 28). Grundlsee, Austria: FSP Scientific Computing.","ista":"Schlögl A, Kiss J. 2017. Scientific Computing at IST Austria. AHPC17 – Austrian HPC Meeting 2017. AHPC: Austrian HPC Meeting, 28.","ieee":"A. Schlögl and J. Kiss, “Scientific Computing at IST Austria,” in <i>AHPC17 – Austrian HPC Meeting 2017</i>, Grundlsee, Austria, 2017, p. 28.","mla":"Schlögl, Alois, and Janos Kiss. “Scientific Computing at IST Austria.” <i>AHPC17 – Austrian HPC Meeting 2017</i>, FSP Scientific Computing, 2017, p. 28.","ama":"Schlögl A, Kiss J. Scientific Computing at IST Austria. In: <i>AHPC17 – Austrian HPC Meeting 2017</i>. FSP Scientific Computing; 2017:28.","short":"A. Schlögl, J. Kiss, in:, AHPC17 – Austrian HPC Meeting 2017, FSP Scientific Computing, 2017, p. 28.","chicago":"Schlögl, Alois, and Janos Kiss. “Scientific Computing at IST Austria.” In <i>AHPC17 – Austrian HPC Meeting 2017</i>, 28. FSP Scientific Computing, 2017."},"oa":1,"date_created":"2023-05-05T12:58:53Z","date_published":"2017-03-03T00:00:00Z","article_processing_charge":"No","publisher":"FSP Scientific Computing","department":[{"_id":"ScienComp"}],"publication_status":"published","page":"28","has_accepted_license":"1","conference":{"start_date":"2017-03-01","end_date":"2017-03-03","name":"AHPC: Austrian HPC Meeting","location":"Grundlsee, Austria"},"file":[{"creator":"dernst","access_level":"open_access","success":1,"content_type":"application/pdf","file_size":1005486,"date_updated":"2023-05-16T07:20:50Z","file_id":"12969","relation":"main_file","checksum":"7bcc499479d4f4c5ce6c0071c24ca6c6","file_name":"2017_AHPC_Schloegl.pdf","date_created":"2023-05-16T07:20:50Z"}],"oa_version":"Published Version","main_file_link":[{"url":"https://vsc.ac.at/fileadmin/user_upload/vsc/conferences/ahpc17/BOOKLET_AHPC17.pdf","open_access":"1"}],"day":"03","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois","last_name":"Schlögl"},{"full_name":"Kiss, Janos","id":"3D3A06F8-F248-11E8-B48F-1D18A9856A87","first_name":"Janos","last_name":"Kiss"}],"type":"conference_abstract","_id":"12905","language":[{"iso":"eng"}],"publication":"AHPC17 – Austrian HPC Meeting 2017","year":"2017","date_updated":"2024-10-09T21:05:23Z","month":"03","title":"Scientific Computing at IST Austria","ddc":["000"],"file_date_updated":"2023-05-16T07:20:50Z","corr_author":"1"},{"status":"public","article_processing_charge":"No","date_created":"2018-12-11T11:47:36Z","date_published":"2017-01-01T00:00:00Z","external_id":{"isi":["000426828000047"]},"abstract":[{"text":"Background: Standards have become available to share semantically encoded vital parameters from medical devices, as required for example by personal healthcare records. Standardised sharing of biosignal data largely remains open. Objectives: The goal of this work is to explore available biosignal file format and data exchange standards and profiles, and to conceptualise end-To-end solutions. Methods: The authors reviewed and discussed available biosignal file format standards with other members of international standards development organisations (SDOs). Results: A raw concept for standards based acquisition, storage, archiving and sharing of biosignals was developed. The GDF format may serve for storing biosignals. Signals can then be shared using FHIR resources and may be stored on FHIR servers or in DICOM archives, with DICOM waveforms as one possible format. Conclusion: Currently a group of international SDOs (e.g. HL7, IHE, DICOM, IEEE) is engaged in intensive discussions. This discussion extends existing work that already was adopted by large implementer communities. The concept presented here only reports the current status of the discussion in Austria. The discussion will continue internationally, with results to be expected over the coming years.","lang":"eng"}],"page":"356 - 362","file":[{"relation":"main_file","date_created":"2018-12-12T10:11:56Z","checksum":"1254dcc5b04a996d97fad9a726b42727","file_name":"IST-2017-906-v1+1_SHTI236-0356.pdf","content_type":"application/pdf","creator":"system","access_level":"open_access","file_id":"4913","date_updated":"2020-07-14T12:47:27Z","file_size":443635}],"publist_id":"7164","author":[{"last_name":"Sauermann","first_name":"Stefan","full_name":"Sauermann, Stefan"},{"full_name":"David, Veronika","first_name":"Veronika","last_name":"David"},{"last_name":"Schlögl","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois"},{"first_name":"Reinhard","full_name":"Egelkraut, Reinhard","last_name":"Egelkraut"},{"first_name":"Matthias","full_name":"Frohner, Matthias","last_name":"Frohner"},{"last_name":"Pohn","first_name":"Birgit","full_name":"Pohn, Birgit"},{"first_name":"Philipp","full_name":"Urbauer, Philipp","last_name":"Urbauer"},{"last_name":"Mense","full_name":"Mense, Alexander","first_name":"Alexander"}],"quality_controlled":"1","year":"2017","language":[{"iso":"eng"}],"isi":1,"publication_identifier":{"isbn":["978-161499758-0"]},"file_date_updated":"2020-07-14T12:47:27Z","pubrep_id":"906","oa":1,"citation":{"chicago":"Sauermann, Stefan, Veronika David, Alois Schlögl, Reinhard Egelkraut, Matthias Frohner, Birgit Pohn, Philipp Urbauer, and Alexander Mense. “Biosignals Standards and FHIR: The Way to Go,” 236:356–62. IOS Press, 2017. <a href=\"https://doi.org/10.3233/978-1-61499-759-7-356\">https://doi.org/10.3233/978-1-61499-759-7-356</a>.","short":"S. Sauermann, V. David, A. Schlögl, R. Egelkraut, M. Frohner, B. Pohn, P. Urbauer, A. Mense, in:, IOS Press, 2017, pp. 356–362.","ama":"Sauermann S, David V, Schlögl A, et al. Biosignals standards and FHIR: The way to go. In: Vol 236. IOS Press; 2017:356-362. doi:<a href=\"https://doi.org/10.3233/978-1-61499-759-7-356\">10.3233/978-1-61499-759-7-356</a>","ieee":"S. Sauermann <i>et al.</i>, “Biosignals standards and FHIR: The way to go,” presented at the eHealth: Health Informatics Meets eHealth, Vienna, Austria, 2017, vol. 236, pp. 356–362.","ista":"Sauermann S, David V, Schlögl A, Egelkraut R, Frohner M, Pohn B, Urbauer P, Mense A. 2017. Biosignals standards and FHIR: The way to go. eHealth: Health Informatics Meets eHealth, Studies in Health Technology and Informatics, vol. 236, 356–362.","apa":"Sauermann, S., David, V., Schlögl, A., Egelkraut, R., Frohner, M., Pohn, B., … Mense, A. (2017). Biosignals standards and FHIR: The way to go (Vol. 236, pp. 356–362). Presented at the eHealth: Health Informatics Meets eHealth, Vienna, Austria: IOS Press. <a href=\"https://doi.org/10.3233/978-1-61499-759-7-356\">https://doi.org/10.3233/978-1-61499-759-7-356</a>","mla":"Sauermann, Stefan, et al. <i>Biosignals Standards and FHIR: The Way to Go</i>. Vol. 236, IOS Press, 2017, pp. 356–62, doi:<a href=\"https://doi.org/10.3233/978-1-61499-759-7-356\">10.3233/978-1-61499-759-7-356</a>."},"publisher":"IOS Press","publication_status":"published","department":[{"_id":"ScienComp"},{"_id":"PeJo"}],"intvolume":"       236","scopus_import":"1","volume":236,"has_accepted_license":"1","conference":{"location":"Vienna, Austria","name":"eHealth: Health Informatics Meets eHealth","start_date":"2017-05-23","end_date":"2017-05-24"},"day":"01","oa_version":"Published Version","doi":"10.3233/978-1-61499-759-7-356","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"type":"conference","date_updated":"2025-09-11T07:27:53Z","_id":"630","month":"01","title":"Biosignals standards and FHIR: The way to go","ddc":["005"],"alternative_title":["Studies in Health Technology and Informatics"]},{"external_id":{"isi":["000382626800045"]},"article_processing_charge":"No","date_published":"2016-09-09T00:00:00Z","date_created":"2018-12-11T11:51:31Z","status":"public","file":[{"content_type":"application/pdf","access_level":"open_access","creator":"system","file_id":"4945","date_updated":"2020-07-14T12:44:46Z","file_size":19408143,"relation":"main_file","date_created":"2018-12-12T10:12:27Z","file_name":"IST-2017-823-v1+1_aaf1836_CombinedPDF_v2-1.pdf","checksum":"89caefa4e181424cbf0aecc835fcc5ec"}],"abstract":[{"text":"The hippocampal CA3 region plays a key role in learning and memory. Recurrent CA3–CA3\r\nsynapses are thought to be the subcellular substrate of pattern completion. However, the\r\nsynaptic mechanisms of this network computation remain enigmatic. To investigate these mechanisms, we combined functional connectivity analysis with network modeling.\r\nSimultaneous recording fromup to eight CA3 pyramidal neurons revealed that connectivity was sparse, spatially uniform, and highly enriched in disynaptic motifs (reciprocal, convergence,divergence, and chain motifs). Unitary connections were composed of one or two synaptic contacts, suggesting efficient use of postsynaptic space. Real-size modeling indicated that CA3 networks with sparse connectivity, disynaptic motifs, and single-contact connections robustly generated pattern completion.Thus, macro- and microconnectivity contribute to efficient\r\nmemory storage and retrieval in hippocampal networks.","lang":"eng"}],"page":"1117 - 1123","acknowledged_ssus":[{"_id":"ScienComp"}],"quality_controlled":"1","publist_id":"5899","author":[{"last_name":"Guzmán","first_name":"José","id":"30CC5506-F248-11E8-B48F-1D18A9856A87","full_name":"Guzmán, José","orcid":"0000-0003-2209-5242"},{"id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois","last_name":"Schlögl"},{"last_name":"Frotscher","first_name":"Michael","full_name":"Frotscher, Michael"},{"orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","last_name":"Jonas"}],"issue":"6304","pubrep_id":"823","file_date_updated":"2020-07-14T12:44:46Z","isi":1,"year":"2016","publication":"Science","language":[{"iso":"eng"}],"intvolume":"       353","publication_status":"published","department":[{"_id":"ScienComp"},{"_id":"PeJo"}],"publisher":"American Association for the Advancement of Science","oa":1,"citation":{"ama":"Guzmán J, Schlögl A, Frotscher M, Jonas PM. Synaptic mechanisms of pattern completion in the hippocampal CA3 network. <i>Science</i>. 2016;353(6304):1117-1123. doi:<a href=\"https://doi.org/10.1126/science.aaf1836\">10.1126/science.aaf1836</a>","short":"J. Guzmán, A. Schlögl, M. Frotscher, P.M. Jonas, Science 353 (2016) 1117–1123.","chicago":"Guzmán, José, Alois Schlögl, Michael Frotscher, and Peter M Jonas. “Synaptic Mechanisms of Pattern Completion in the Hippocampal CA3 Network.” <i>Science</i>. American Association for the Advancement of Science, 2016. <a href=\"https://doi.org/10.1126/science.aaf1836\">https://doi.org/10.1126/science.aaf1836</a>.","ista":"Guzmán J, Schlögl A, Frotscher M, Jonas PM. 2016. Synaptic mechanisms of pattern completion in the hippocampal CA3 network. Science. 353(6304), 1117–1123.","ieee":"J. Guzmán, A. Schlögl, M. Frotscher, and P. M. Jonas, “Synaptic mechanisms of pattern completion in the hippocampal CA3 network,” <i>Science</i>, vol. 353, no. 6304. American Association for the Advancement of Science, pp. 1117–1123, 2016.","apa":"Guzmán, J., Schlögl, A., Frotscher, M., &#38; Jonas, P. M. (2016). Synaptic mechanisms of pattern completion in the hippocampal CA3 network. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aaf1836\">https://doi.org/10.1126/science.aaf1836</a>","mla":"Guzmán, José, et al. “Synaptic Mechanisms of Pattern Completion in the Hippocampal CA3 Network.” <i>Science</i>, vol. 353, no. 6304, American Association for the Advancement of Science, 2016, pp. 1117–23, doi:<a href=\"https://doi.org/10.1126/science.aaf1836\">10.1126/science.aaf1836</a>."},"oa_version":"Preprint","day":"09","doi":"10.1126/science.aaf1836","project":[{"name":"Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons","grant_number":"268548","_id":"25C0F108-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"},{"name":"Mechanisms of transmitter release at GABAergic synapses","grant_number":"P24909-B24","call_identifier":"FWF","_id":"25C26B1E-B435-11E9-9278-68D0E5697425"}],"volume":353,"scopus_import":"1","has_accepted_license":"1","ec_funded":1,"type":"journal_article","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","corr_author":"1","title":"Synaptic mechanisms of pattern completion in the hippocampal CA3 network","ddc":["570"],"month":"09","date_updated":"2025-09-22T08:12:10Z","_id":"1350"},{"publisher":"VSC - Vienna Scientific Cluster","article_processing_charge":"No","date_created":"2023-05-05T12:54:47Z","date_published":"2016-02-24T00:00:00Z","oa":1,"status":"public","citation":{"mla":"Schlögl, Alois, and Stephan Stadlbauer. “High Performance Computing at IST Austria: Modelling the Human Hippocampus.” <i>AHPC16 - Austrian HPC Meeting 2016</i>, VSC - Vienna Scientific Cluster, 2016, p. 37.","apa":"Schlögl, A., &#38; Stadlbauer, S. (2016). High performance computing at IST Austria: Modelling the human hippocampus. In <i>AHPC16 - Austrian HPC Meeting 2016</i> (p. 37). Grundlsee, Austria: VSC - Vienna Scientific Cluster.","ista":"Schlögl A, Stadlbauer S. 2016. High performance computing at IST Austria: Modelling the human hippocampus. AHPC16 - Austrian HPC Meeting 2016. AHPC: Austrian HPC Meeting, 37.","ieee":"A. Schlögl and S. Stadlbauer, “High performance computing at IST Austria: Modelling the human hippocampus,” in <i>AHPC16 - Austrian HPC Meeting 2016</i>, Grundlsee, Austria, 2016, p. 37.","ama":"Schlögl A, Stadlbauer S. High performance computing at IST Austria: Modelling the human hippocampus. In: <i>AHPC16 - Austrian HPC Meeting 2016</i>. VSC - Vienna Scientific Cluster; 2016:37.","short":"A. Schlögl, S. Stadlbauer, in:, AHPC16 - Austrian HPC Meeting 2016, VSC - Vienna Scientific Cluster, 2016, p. 37.","chicago":"Schlögl, Alois, and Stephan Stadlbauer. “High Performance Computing at IST Austria: Modelling the Human Hippocampus.” In <i>AHPC16 - Austrian HPC Meeting 2016</i>, 37. VSC - Vienna Scientific Cluster, 2016."},"publication_status":"published","department":[{"_id":"ScienComp"},{"_id":"PeJo"}],"conference":{"end_date":"2016-02-24","start_date":"2016-02-22","location":"Grundlsee, Austria","name":"AHPC: Austrian HPC Meeting"},"file":[{"relation":"main_file","file_name":"2016_AHPC_Schloegl.pdf","checksum":"4a7b00362e81358d568f5e216fa03c3e","date_created":"2023-05-16T07:03:56Z","success":1,"creator":"dernst","access_level":"open_access","content_type":"application/pdf","date_updated":"2023-05-16T07:03:56Z","file_size":1073523,"file_id":"12968"}],"page":"37","has_accepted_license":"1","day":"24","oa_version":"Published Version","main_file_link":[{"open_access":"1","url":"https://vsc.ac.at/fileadmin/user_upload/vsc/conferences/ahpc16/BOOKLET_AHPC16.pdf"}],"type":"conference_abstract","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois","last_name":"Schlögl"},{"last_name":"Stadlbauer","id":"4D0BC184-F248-11E8-B48F-1D18A9856A87","first_name":"Stephan","full_name":"Stadlbauer, Stephan"}],"month":"02","date_updated":"2024-10-09T21:05:23Z","year":"2016","_id":"12903","language":[{"iso":"eng"}],"publication":"AHPC16 - Austrian HPC Meeting 2016","corr_author":"1","file_date_updated":"2023-05-16T07:03:56Z","ddc":["000"],"title":"High performance computing at IST Austria: Modelling the human hippocampus"},{"month":"03","date_updated":"2022-03-04T07:34:45Z","_id":"10810","title":"SCP-ECG V3.0: An enhanced standard communication protocol for computer-assisted electrocardiography","type":"conference","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","conference":{"name":"CinC: Computing in Cardiology","location":"Vancouver, Canada","start_date":"2016-09-11","end_date":"2016-09-14"},"volume":43,"scopus_import":"1","oa_version":"Published Version","main_file_link":[{"url":"https://doi.org/10.22489/cinc.2016.090-500","open_access":"1"}],"day":"01","doi":"10.22489/cinc.2016.090-500","publisher":"Computing in Cardiology","oa":1,"citation":{"mla":"Rubel, Paul, et al. “SCP-ECG V3.0: An Enhanced Standard Communication Protocol for Computer-Assisted Electrocardiography.” <i>2016 Computing in Cardiology Conference</i>, vol. 43, Computing in Cardiology, 2016, pp. 309–12, doi:<a href=\"https://doi.org/10.22489/cinc.2016.090-500\">10.22489/cinc.2016.090-500</a>.","ieee":"P. Rubel <i>et al.</i>, “SCP-ECG V3.0: An enhanced standard communication protocol for computer-assisted electrocardiography,” in <i>2016 Computing in Cardiology Conference</i>, Vancouver, Canada, 2016, vol. 43, pp. 309–312.","ista":"Rubel P, Pani D, Schlögl A, Fayn J, Badilini F, Macfarlane P, Varri A. 2016. SCP-ECG V3.0: An enhanced standard communication protocol for computer-assisted electrocardiography. 2016 Computing in Cardiology Conference. CinC: Computing in Cardiology vol. 43, 309–312.","apa":"Rubel, P., Pani, D., Schlögl, A., Fayn, J., Badilini, F., Macfarlane, P., &#38; Varri, A. (2016). SCP-ECG V3.0: An enhanced standard communication protocol for computer-assisted electrocardiography. In <i>2016 Computing in Cardiology Conference</i> (Vol. 43, pp. 309–312). Vancouver, Canada: Computing in Cardiology. <a href=\"https://doi.org/10.22489/cinc.2016.090-500\">https://doi.org/10.22489/cinc.2016.090-500</a>","chicago":"Rubel, Paul, Danilo Pani, Alois Schlögl, Jocelyne Fayn, Fabio Badilini, Peter Macfarlane, and Alpo Varri. “SCP-ECG V3.0: An Enhanced Standard Communication Protocol for Computer-Assisted Electrocardiography.” In <i>2016 Computing in Cardiology Conference</i>, 43:309–12. Computing in Cardiology, 2016. <a href=\"https://doi.org/10.22489/cinc.2016.090-500\">https://doi.org/10.22489/cinc.2016.090-500</a>.","short":"P. Rubel, D. Pani, A. Schlögl, J. Fayn, F. Badilini, P. Macfarlane, A. Varri, in:, 2016 Computing in Cardiology Conference, Computing in Cardiology, 2016, pp. 309–312.","ama":"Rubel P, Pani D, Schlögl A, et al. SCP-ECG V3.0: An enhanced standard communication protocol for computer-assisted electrocardiography. In: <i>2016 Computing in Cardiology Conference</i>. Vol 43. Computing in Cardiology; 2016:309-312. doi:<a href=\"https://doi.org/10.22489/cinc.2016.090-500\">10.22489/cinc.2016.090-500</a>"},"intvolume":"        43","publication_status":"published","department":[{"_id":"CampIT"}],"publication_identifier":{"issn":["2325-887X"]},"language":[{"iso":"eng"}],"year":"2016","publication":"2016 Computing in Cardiology Conference","acknowledgement":"The authors are thankful to Drs. Roger Abaecherli, Nikus Kjell, Paul Kligfield, Jay Mason, Patrice Nony, Vito Starc, Anders Thurin and the late Galen Wagner for their in depth review and constructive comments.","quality_controlled":"1","author":[{"last_name":"Rubel","full_name":"Rubel, Paul","first_name":"Paul"},{"last_name":"Pani","first_name":"Danilo","full_name":"Pani, Danilo"},{"last_name":"Schlögl","full_name":"Schlögl, Alois","orcid":"0000-0002-5621-8100","first_name":"Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Fayn","full_name":"Fayn, Jocelyne","first_name":"Jocelyne"},{"last_name":"Badilini","full_name":"Badilini, Fabio","first_name":"Fabio"},{"first_name":"Peter","full_name":"Macfarlane, Peter","last_name":"Macfarlane"},{"last_name":"Varri","full_name":"Varri, Alpo","first_name":"Alpo"}],"abstract":[{"lang":"eng","text":"The main goal of the SCP-ECG standard is to address ECG data and related metadata structuring, semantics and syntax, with the objective of facilitating interoperability and thus supporting and promoting the exchange of the relevant information for unary and serial ECG diagnosis. Starting with version V3.0, the standard now also provides support for the storage of continuous, long-term ECG recordings and affords a repository for selected ECG sequences and the related metadata to accommodate stress tests, drug trials and protocol-based ECG recordings. The global and per-lead measurements sections have been extended and three new sections have been introduced for storing beat-by-beat and/or spike-by-spike measurements\r\nand annotations. The used terminology and the provided measurements and annotations have been harmonized with the ISO/IEEE 11073-10102 Annotated ECG standard. Emphasis has also been put on harmonizing the Universal Statement Codes with the CDISC and the categorized AHA statement codes and similarly the drug and implanted devices codes with the ATC and NASPE/BPEG codes. "}],"page":"309-312","article_processing_charge":"No","date_published":"2016-03-01T00:00:00Z","date_created":"2022-03-03T10:43:10Z","status":"public"},{"month":"02","_id":"1890","date_updated":"2025-09-29T13:07:21Z","ddc":["000"],"title":"Sequential effects in continued visual search: Using fixation-related potentials to compare distractor processing before and after target detection","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","volume":51,"has_accepted_license":"1","scopus_import":"1","doi":"10.1111/psyp.12062","day":"11","oa_version":"Published Version","publisher":"Wiley-Blackwell","citation":{"mla":"Körner, Christof, et al. “Sequential Effects in Continued Visual Search: Using Fixation-Related Potentials to Compare Distractor Processing before and after Target Detection.” <i>Psychophysiology</i>, vol. 51, no. 4, Wiley-Blackwell, 2014, pp. 385–95, doi:<a href=\"https://doi.org/10.1111/psyp.12062\">10.1111/psyp.12062</a>.","apa":"Körner, C., Braunstein, V., Stangl, M., Schlögl, A., Neuper, C., &#38; Ischebeck, A. (2014). Sequential effects in continued visual search: Using fixation-related potentials to compare distractor processing before and after target detection. <i>Psychophysiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/psyp.12062\">https://doi.org/10.1111/psyp.12062</a>","ista":"Körner C, Braunstein V, Stangl M, Schlögl A, Neuper C, Ischebeck A. 2014. Sequential effects in continued visual search: Using fixation-related potentials to compare distractor processing before and after target detection. Psychophysiology. 51(4), 385–395.","ieee":"C. Körner, V. Braunstein, M. Stangl, A. Schlögl, C. Neuper, and A. Ischebeck, “Sequential effects in continued visual search: Using fixation-related potentials to compare distractor processing before and after target detection,” <i>Psychophysiology</i>, vol. 51, no. 4. Wiley-Blackwell, pp. 385–395, 2014.","short":"C. Körner, V. Braunstein, M. Stangl, A. Schlögl, C. Neuper, A. Ischebeck, Psychophysiology 51 (2014) 385–395.","ama":"Körner C, Braunstein V, Stangl M, Schlögl A, Neuper C, Ischebeck A. Sequential effects in continued visual search: Using fixation-related potentials to compare distractor processing before and after target detection. <i>Psychophysiology</i>. 2014;51(4):385-395. doi:<a href=\"https://doi.org/10.1111/psyp.12062\">10.1111/psyp.12062</a>","chicago":"Körner, Christof, Verena Braunstein, Matthias Stangl, Alois Schlögl, Christa Neuper, and Anja Ischebeck. “Sequential Effects in Continued Visual Search: Using Fixation-Related Potentials to Compare Distractor Processing before and after Target Detection.” <i>Psychophysiology</i>. Wiley-Blackwell, 2014. <a href=\"https://doi.org/10.1111/psyp.12062\">https://doi.org/10.1111/psyp.12062</a>."},"oa":1,"intvolume":"        51","department":[{"_id":"ScienComp"},{"_id":"PeJo"}],"publication_status":"published","isi":1,"year":"2014","language":[{"iso":"eng"}],"publication":"Psychophysiology","acknowledgement":"Funded by Austrian Science Fund (FWF) Grant Number: P 22189-B18; European Union within the 6th Framework Programme Grant Number: 517590; State government of Styria Grant Number: PN 4055","file_date_updated":"2020-07-14T12:45:20Z","pubrep_id":"442","author":[{"full_name":"Körner, Christof","first_name":"Christof","last_name":"Körner"},{"full_name":"Braunstein, Verena","first_name":"Verena","last_name":"Braunstein"},{"last_name":"Stangl","full_name":"Stangl, Matthias","first_name":"Matthias"},{"id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","full_name":"Schlögl, Alois","orcid":"0000-0002-5621-8100","last_name":"Schlögl"},{"last_name":"Neuper","full_name":"Neuper, Christa","first_name":"Christa"},{"last_name":"Ischebeck","full_name":"Ischebeck, Anja","first_name":"Anja"}],"issue":"4","publist_id":"5205","file":[{"relation":"main_file","date_created":"2018-12-12T10:16:44Z","checksum":"4255b6185e774acce1d99f8e195c564d","file_name":"IST-2016-442-v1+1_K-rner_et_al-2014-Psychophysiology.pdf","content_type":"application/pdf","access_level":"open_access","creator":"system","file_id":"5233","date_updated":"2020-07-14T12:45:20Z","file_size":543243}],"page":"385 - 395","abstract":[{"lang":"eng","text":"To search for a target in a complex environment is an everyday behavior that ends with finding the target. When we search for two identical targets, however, we must continue the search after finding the first target and memorize its location. We used fixation-related potentials to investigate the neural correlates of different stages of the search, that is, before and after finding the first target. Having found the first target influenced subsequent distractor processing. Compared to distractor fixations before the first target fixation, a negative shift was observed for three subsequent distractor fixations. These results suggest that processing a target in continued search modulates the brain's response, either transiently by reflecting temporary working memory processes or permanently by reflecting working memory retention."}],"date_published":"2014-02-11T00:00:00Z","date_created":"2018-12-11T11:54:34Z","article_processing_charge":"No","status":"public","external_id":{"isi":["000332585900010"]}}]