---
APC_amount: 6828 EUR
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18444'
abstract:
- lang: eng
text: Animals rely on compensatory actions to maintain stability and navigate their
environment efficiently. These actions depend on global visual motion cues known
as optic-flow. While the optomotor response has been the traditional focus for
studying optic-flow compensation in insects, its simplicity has been insufficient
to determine the role of the intricate optic-flow processing network involved
in visual course control. Here, we reveal a series of course control behaviours
in Drosophila and link them to specific neural circuits. We show that bilateral
electrical coupling of optic-flow-sensitive neurons in the fly’s lobula plate
are required for a proper course control. This electrical interaction works alongside
chemical synapses within the HS-H2 network to control the dynamics and direction
of turning behaviours. Our findings reveal how insects use bilateral motion cues
for navigation, assigning a new functional significance to the HS-H2 network and
suggesting a previously unknown role for gap junctions in non-linear operations.
acknowledged_ssus:
- _id: Bio
- _id: M-Shop
- _id: LifeSc
acknowledgement: We thank Georg Ammer and Alexander Borst for sharing anti-ShakB serum
antibodies. We thank Nélia Varela and Eugenia Chiappe for the w1118;+;10XUAS-IVS-eGFPKir2.1/TM6B
fly line, Augustin Hrvoje for the shakB[2] line, as well as Jesse Isaacman-Beck
and Thomas R Clandinin for the gift of y1,w*;20XUAS-IVS-PhiC31;+ fly line. We also
thank Armel Nicolas and Tomas Masson for the proteomic analysis, Ece Sönmez for
help with fly crosses and dissections for protein analysis, and Lisa Hofer for assistance
with the reconstruction experiments. We would also like to thank Laura Burnett for
drawing scientific illustrations used in the figures. We are particularly grateful
to members of the Siekhaus, the Kondrashov, and the Chiappe group for providing
material support and technical advice. We are grateful to Daria Siekhaus, Eugenia
Chiappe, Alexander Borst, Ben deBivort, and all the members of the Joesch laboratory
for valuable discussions and comments on the manuscript. Stocks from the Bloomington
Drosophila Stock Center (NIH P40OD018537) and the Vienna Drosophila Resource Center
were used in this study. The Scientific Service Units of ISTA supported the project
through resources provided by the Imaging and Optics Facility, MIBA Machine Shop,
and the Lab Support Facility, as well as Vienna Drosophila Research Centre. This
work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
as part of the SPP 2205 – 429960716 (M.J.).
article_number: '8830'
article_processing_charge: Yes
article_type: original
author:
- first_name: Victoria
full_name: Pokusaeva, Victoria
id: 3184041C-F248-11E8-B48F-1D18A9856A87
last_name: Pokusaeva
orcid: 0000-0001-7660-444X
- first_name: Roshan K
full_name: Satapathy, Roshan K
id: 46046B7A-F248-11E8-B48F-1D18A9856A87
last_name: Satapathy
orcid: 0009-0006-2974-5075
- first_name: Olga
full_name: Symonova, Olga
id: 3C0C7BC6-F248-11E8-B48F-1D18A9856A87
last_name: Symonova
orcid: 0000-0003-2012-9947
- first_name: Maximilian A
full_name: Jösch, Maximilian A
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
citation:
ama: Pokusaeva V, Satapathy RK, Symonova O, Jösch MA. Bilateral interactions of
optic-flow sensitive neurons coordinate course control in flies. Nature Communications.
2024;15. doi:10.1038/s41467-024-53173-w
apa: Pokusaeva, V., Satapathy, R. K., Symonova, O., & Jösch, M. A. (2024). Bilateral
interactions of optic-flow sensitive neurons coordinate course control in flies.
Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-024-53173-w
chicago: Pokusaeva, Victoria, Roshan K Satapathy, Olga Symonova, and Maximilian
A Jösch. “Bilateral Interactions of Optic-Flow Sensitive Neurons Coordinate Course
Control in Flies.” Nature Communications. Springer Nature, 2024. https://doi.org/10.1038/s41467-024-53173-w.
ieee: V. Pokusaeva, R. K. Satapathy, O. Symonova, and M. A. Jösch, “Bilateral interactions
of optic-flow sensitive neurons coordinate course control in flies,” Nature
Communications, vol. 15. Springer Nature, 2024.
ista: Pokusaeva V, Satapathy RK, Symonova O, Jösch MA. 2024. Bilateral interactions
of optic-flow sensitive neurons coordinate course control in flies. Nature Communications.
15, 8830.
mla: Pokusaeva, Victoria, et al. “Bilateral Interactions of Optic-Flow Sensitive
Neurons Coordinate Course Control in Flies.” Nature Communications, vol.
15, 8830, Springer Nature, 2024, doi:10.1038/s41467-024-53173-w.
short: V. Pokusaeva, R.K. Satapathy, O. Symonova, M.A. Jösch, Nature Communications
15 (2024).
corr_author: '1'
date_created: 2024-10-20T22:02:05Z
date_published: 2024-10-12T00:00:00Z
date_updated: 2026-06-10T07:58:34Z
day: '12'
ddc:
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department:
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doi: 10.1038/s41467-024-53173-w
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name: Evolution of Sensorimotor Transformation Across Diptera
publication: Nature Communications
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title: Bilateral interactions of optic-flow sensitive neurons coordinate course control
in flies
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abstract:
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text: "Locomotion is ubiquitous in the animal kingdom because an animal's survival
depends on its ability to navigate its environment to find food, avoid predators
and locate potential mates. These behaviours require control mechanisms that can
extract information from the environment, particularly visual cues. Selective
evolutionary pressures have thus refined such visuomotor transformations in a
species-specific manner to meet the specific ecological and ethological challenges
of each organism. However, a common challenge across organisms as visual information
processing\r\nbecomes increasingly detailed is the mechanisms required to synthesise
disparate pieces of information into a coherent percept or unified picture of
the world. In this thesis, I investigate how disparate visual information is combined
in the brain of Drosophila melanogaster to effectively guide locomotion.\r\nFor
this, I first designed and built a behavioural setup to record locomotion and
present visual stimuli to freely-walking fruit flies in a closed-loop manner.
This setup allowed the investigation of innate visually-guided behaviours, including
the optomotor reflex and courtship.\r\nSecond, taking advantage of my system I
investigated the optomotor response, a reflexive visual stabilisation behaviour
in which flies turn in the direction of global motion to minimise retinal slip.
This behaviour is thought to be mediated by Lobula plate tangential cells (LPTCs);
a complex network of optic-flow-sensitive neurons essential for self-motion estimation.
Using a novel genetic mutant, I demonstrate that electrical coupling between two
LPTC subtypes, contralateral HS and H2 neurons, regulates the balance between
smooth optomotor turning and saccadic anti-optomotor responses. These findings
underscore the critical role of binocular motion cue integration in guiding course
control. Finally, I developed a novel behavioural paradigm in which a sexually
aroused male fruit fly is presented with an optomotor distractor. This setup creates
competition between two visual behaviours, courtship tracking and the optomotor
response, enabling me to explore how the visual system resolves this conflict.
In this setting, males\r\nengaged in courtship selectively suppress their optomotor
response based on the female's location. Furthermore, when this experiment is
replicated with an “artificial female”, optogenetically aroused males alternate
between tracking and optomotor responses. The probability and dynamics of this
switching are determined by the relative strengths of the two competing stimuli.
In summary, the results presented in this thesis explore two mechanisms – integration
and competition - through which visual information is combined in the brain of
the fruit fly to drive locomotion."
acknowledged_ssus:
- _id: M-Shop
acknowledgement: I am incredibly thankful for the outstanding support provided by
ISTA, especially the Machine Shop team, who made conducting research much easier
and more efficient. I am also grateful for the funding provided by European Union’s
Horizon 2020 research and innovation program under the Marie Skłodowska-Curie programme
(665385) and The German Research Foundation grant DFG (SPP2205) “Evolutionary optimization
of neuronal processing”.
alternative_title:
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author:
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full_name: Satapathy, Roshan K
id: 46046B7A-F248-11E8-B48F-1D18A9856A87
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orcid: 0009-0006-2974-5075
citation:
ama: Satapathy RK. Mechanisms of visual integration and competition in innate behaviours
in Drosophila melanogaster. 2024. doi:10.15479/at:ista:18568
apa: Satapathy, R. K. (2024). Mechanisms of visual integration and competition
in innate behaviours in Drosophila melanogaster. Institute of Science and
Technology Austria. https://doi.org/10.15479/at:ista:18568
chicago: Satapathy, Roshan K. “Mechanisms of Visual Integration and Competition
in Innate Behaviours in Drosophila Melanogaster.” Institute of Science and Technology
Austria, 2024. https://doi.org/10.15479/at:ista:18568.
ieee: R. K. Satapathy, “Mechanisms of visual integration and competition in innate
behaviours in Drosophila melanogaster,” Institute of Science and Technology Austria,
2024.
ista: Satapathy RK. 2024. Mechanisms of visual integration and competition in innate
behaviours in Drosophila melanogaster. Institute of Science and Technology Austria.
mla: Satapathy, Roshan K. Mechanisms of Visual Integration and Competition in
Innate Behaviours in Drosophila Melanogaster. Institute of Science and Technology
Austria, 2024, doi:10.15479/at:ista:18568.
short: R.K. Satapathy, Mechanisms of Visual Integration and Competition in Innate
Behaviours in Drosophila Melanogaster, Institute of Science and Technology Austria,
2024.
corr_author: '1'
date_created: 2024-11-19T12:34:30Z
date_published: 2024-11-20T00:00:00Z
date_updated: 2026-04-07T13:00:36Z
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call_identifier: H2020
grant_number: '665385'
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publication_identifier:
isbn:
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issn:
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id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
title: Mechanisms of visual integration and competition in innate behaviours in Drosophila
melanogaster
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short: CC BY-SA (4.0)
type: dissertation
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...
---
_id: '17488'
abstract:
- lang: eng
text: Behavioural data for Pokusaeva, Satapathy et al. Relevant information can
be found in the 'README.txt' file.
acknowledged_ssus:
- _id: M-Shop
article_processing_charge: No
author:
- first_name: Roshan K
full_name: Satapathy, Roshan K
id: 46046B7A-F248-11E8-B48F-1D18A9856A87
last_name: Satapathy
orcid: 0009-0006-2974-5075
- first_name: Maximilian A
full_name: Jösch, Maximilian A
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
- first_name: Olga
full_name: Symonova, Olga
id: 3C0C7BC6-F248-11E8-B48F-1D18A9856A87
last_name: Symonova
orcid: 0000-0003-2012-9947
- first_name: Victoria
full_name: Pokusaeva, Victoria
id: 3184041C-F248-11E8-B48F-1D18A9856A87
last_name: Pokusaeva
orcid: 0000-0001-7660-444X
citation:
ama: Satapathy RK, Jösch MA, Symonova O, Pokusaeva V. Bilateral interactions of
optic-flow sensitive neurons coordinate course control in flies. 2024. doi:10.15479/AT:ISTA:17488
apa: Satapathy, R. K., Jösch, M. A., Symonova, O., & Pokusaeva, V. (2024). Bilateral
interactions of optic-flow sensitive neurons coordinate course control in flies.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:17488
chicago: Satapathy, Roshan K, Maximilian A Jösch, Olga Symonova, and Victoria Pokusaeva.
“Bilateral Interactions of Optic-Flow Sensitive Neurons Coordinate Course Control
in Flies.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/AT:ISTA:17488.
ieee: R. K. Satapathy, M. A. Jösch, O. Symonova, and V. Pokusaeva, “Bilateral interactions
of optic-flow sensitive neurons coordinate course control in flies.” Institute
of Science and Technology Austria, 2024.
ista: Satapathy RK, Jösch MA, Symonova O, Pokusaeva V. 2024. Bilateral interactions
of optic-flow sensitive neurons coordinate course control in flies, Institute
of Science and Technology Austria, 10.15479/AT:ISTA:17488.
mla: Satapathy, Roshan K., et al. Bilateral Interactions of Optic-Flow Sensitive
Neurons Coordinate Course Control in Flies. Institute of Science and Technology
Austria, 2024, doi:10.15479/AT:ISTA:17488.
short: R.K. Satapathy, M.A. Jösch, O. Symonova, V. Pokusaeva, (2024).
corr_author: '1'
date_created: 2024-09-03T17:42:46Z
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date_updated: 2026-06-10T07:58:35Z
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keyword:
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- locomotion
- gap junctions
month: '09'
oa: 1
oa_version: Published Version
project:
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grant_number: '429960716'
name: Evolution of Sensorimotor Transformation Across Diptera
publisher: Institute of Science and Technology Austria
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title: Bilateral interactions of optic-flow sensitive neurons coordinate course control
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...
---
_id: '8151'
abstract:
- lang: eng
text: The main idea behind the Core Project is to teach first year students at IST
scientific communication skills and let them practice by presenting their research
within an interdisciplinary environment. Over the course of the first semester,
students participated in seminars, where they shared their results with the colleagues
from other fields and took part in discussions on relevant subjects. The main
focus during this sessions was on delivering the information in a simplified and
comprehensible way, going into the very basics of a subject if necessary. At the
end, the students were asked to present their research in the written form to
exercise their writing skills. The reports were gathered in this document. All
of them were reviewed by the teaching assistants and write-ups illustrating unique
stylistic features and, in general, an outstanding level of writing skills, were
honorably mentioned in the section "Selected Reports".
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full_name: Maslov, Mikhail
id: 2E65BB0E-F248-11E8-B48F-1D18A9856A87
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orcid: 0000-0003-4074-2570
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id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
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last_name: Hennessey-Wesen
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last_name: Kavcic
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last_name: Machnik
orcid: 0000-0001-6617-9742
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full_name: Satapathy, Roshan K
id: 46046B7A-F248-11E8-B48F-1D18A9856A87
last_name: Satapathy
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id: 3981F020-F248-11E8-B48F-1D18A9856A87
last_name: Tomanek
orcid: 0000-0001-6197-363X
citation:
ama: Maslov M, Kondrashov F, Artner C, et al. Core Project Proceedings. IST
Austria; 2020.
apa: Maslov, M., Kondrashov, F., Artner, C., Hennessey-Wesen, M., Kavcic, B., Machnik,
N. N., … Tomanek, I. (2020). Core Project Proceedings. IST Austria.
chicago: Maslov, Mikhail, Fyodor Kondrashov, Christina Artner, Mike Hennessey-Wesen,
Bor Kavcic, Nick N Machnik, Roshan K Satapathy, and Isabella Tomanek. Core
Project Proceedings. IST Austria, 2020.
ieee: M. Maslov et al., Core Project Proceedings. IST Austria, 2020.
ista: Maslov M, Kondrashov F, Artner C, Hennessey-Wesen M, Kavcic B, Machnik NN,
Satapathy RK, Tomanek I. 2020. Core Project Proceedings, IST Austria, 425p.
mla: Maslov, Mikhail, et al. Core Project Proceedings. IST Austria, 2020.
short: M. Maslov, F. Kondrashov, C. Artner, M. Hennessey-Wesen, B. Kavcic, N.N.
Machnik, R.K. Satapathy, I. Tomanek, Core Project Proceedings, IST Austria, 2020.
date_created: 2020-07-22T14:48:14Z
date_published: 2020-01-28T00:00:00Z
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publication_status: published
publisher: IST Austria
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title: Core Project Proceedings
type: report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...