---
_id: '18153'
abstract:
- lang: eng
  text: Attention supports decision making by selecting the features that are relevant
    for decisions. Selective enhancement of the relevant features and inhibition of
    distractors has been proposed as potential neural mechanisms driving this selection
    process. Yet, how attention operates when relevance cannot be directly determined,
    and the attention signal needs to be internally constructed is less understood.
    Here we recorded from populations of neurons in the anterior cingulate cortex
    (ACC) of mice in an attention-shifting task where relevance of stimulus modalities
    changed across blocks of trials. In contrast with V1 recordings, decoding of the
    irrelevant modality gradually declined in ACC after an initial transient. Our
    analytical proof and a recurrent neural network model of the task revealed mutually
    inhibiting connections that produced context-gated suppression as observed in
    mice. Using this RNN model we predicted a correlation between contextual modulation
    of individual neurons and their stimulus drive, which we confirmed in ACC but
    not in V1.
article_number: '5559'
article_processing_charge: Yes
article_type: original
author:
- first_name: Márton Albert
  full_name: Hajnal, Márton Albert
  last_name: Hajnal
- first_name: Duy
  full_name: Tran, Duy
  last_name: Tran
- first_name: Zsombor
  full_name: Szabó, Zsombor
  id: 47757b1e-3f56-11ef-9908-8ddefb4d05eb
  last_name: Szabó
  orcid: 0009-0003-8524-4994
- first_name: Andrea
  full_name: Albert, Andrea
  last_name: Albert
- first_name: Karen
  full_name: Safaryan, Karen
  last_name: Safaryan
- first_name: Michael
  full_name: Einstein, Michael
  last_name: Einstein
- first_name: Mauricio
  full_name: Vallejo Martelo, Mauricio
  last_name: Vallejo Martelo
- first_name: Pierre-Olivier
  full_name: Polack, Pierre-Olivier
  last_name: Polack
- first_name: Peyman
  full_name: Golshani, Peyman
  last_name: Golshani
- first_name: Gergő
  full_name: Orbán, Gergő
  last_name: Orbán
citation:
  ama: Hajnal MA, Tran D, Szabó Z, et al. Shifts in attention drive context-dependent
    subspace encoding in anterior cingulate cortex in mice during decision making.
    <i>Nature Communications</i>. 2024;15. doi:<a href="https://doi.org/10.1038/s41467-024-49845-2">10.1038/s41467-024-49845-2</a>
  apa: Hajnal, M. A., Tran, D., Szabó, Z., Albert, A., Safaryan, K., Einstein, M.,
    … Orbán, G. (2024). Shifts in attention drive context-dependent subspace encoding
    in anterior cingulate cortex in mice during decision making. <i>Nature Communications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41467-024-49845-2">https://doi.org/10.1038/s41467-024-49845-2</a>
  chicago: Hajnal, Márton Albert, Duy Tran, Zsombor Szabó, Andrea Albert, Karen Safaryan,
    Michael Einstein, Mauricio Vallejo Martelo, Pierre-Olivier Polack, Peyman Golshani,
    and Gergő Orbán. “Shifts in Attention Drive Context-Dependent Subspace Encoding
    in Anterior Cingulate Cortex in Mice during Decision Making.” <i>Nature Communications</i>.
    Springer Nature, 2024. <a href="https://doi.org/10.1038/s41467-024-49845-2">https://doi.org/10.1038/s41467-024-49845-2</a>.
  ieee: M. A. Hajnal <i>et al.</i>, “Shifts in attention drive context-dependent subspace
    encoding in anterior cingulate cortex in mice during decision making,” <i>Nature
    Communications</i>, vol. 15. Springer Nature, 2024.
  ista: Hajnal MA, Tran D, Szabó Z, Albert A, Safaryan K, Einstein M, Vallejo Martelo
    M, Polack P-O, Golshani P, Orbán G. 2024. Shifts in attention drive context-dependent
    subspace encoding in anterior cingulate cortex in mice during decision making.
    Nature Communications. 15, 5559.
  mla: Hajnal, Márton Albert, et al. “Shifts in Attention Drive Context-Dependent
    Subspace Encoding in Anterior Cingulate Cortex in Mice during Decision Making.”
    <i>Nature Communications</i>, vol. 15, 5559, Springer Nature, 2024, doi:<a href="https://doi.org/10.1038/s41467-024-49845-2">10.1038/s41467-024-49845-2</a>.
  short: M.A. Hajnal, D. Tran, Z. Szabó, A. Albert, K. Safaryan, M. Einstein, M. Vallejo
    Martelo, P.-O. Polack, P. Golshani, G. Orbán, Nature Communications 15 (2024).
date_created: 2024-09-28T06:59:03Z
date_published: 2024-07-02T00:00:00Z
date_updated: 2024-10-01T07:14:56Z
day: '02'
ddc:
- '570'
doi: 10.1038/s41467-024-49845-2
extern: '1'
external_id:
  pmid:
  - '37873364'
file:
- access_level: open_access
  checksum: 22caa17a6691884c66c650c61227e903
  content_type: application/pdf
  creator: dernst
  date_created: 2024-10-01T07:13:36Z
  date_updated: 2024-10-01T07:13:36Z
  file_id: '18163'
  file_name: 2024_NatureComm_Hajnal.pdf
  file_size: 4346510
  relation: main_file
  success: 1
file_date_updated: 2024-10-01T07:13:36Z
fulldoi: https://doi.org/10.1038/s41467-024-49845-2
has_accepted_license: '1'
intvolume: '        15'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  issn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Shifts in attention drive context-dependent subspace encoding in anterior cingulate
  cortex in mice during decision making
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2024'
...