[{"file_date_updated":"2026-03-09T10:32:02Z","date_updated":"2026-03-09T10:33:04Z","publication":"Molecular Biology and Evolution","PlanS_conform":"1","status":"public","license":"https://creativecommons.org/licenses/by/4.0/","issue":"2","DOAJ_listed":"1","scopus_import":"1","external_id":{"pmid":["41589062"]},"_id":"21409","abstract":[{"text":"Meiotic drivers are selfish genetic elements that gain transmission advantages by distorting equal, Mendelian segregation. For decades, biologists have considered meiotic drivers as interesting, albeit esoteric, case studies. It is now clear, however, that meiotic drive is more common and phylogenetically widespread than previously supposed. Indeed, intensive study of a few well-known cases has begun to reveal the evolutionary genomic consequences of meiotic drive. We argue here that many features of genome evolution, content, and organization that are seemingly inexplicable by organismal adaptation or nearly neutral processes are instead best accounted for by recurrent histories of meiotic drive. We review how meiotic drive can affect the evolution of sequences, gene copy numbers, genes with functions in meiosis and gametogenesis, signatures of “selection,” chromosome rearrangements, and karyotype evolution. We also explore the interactions of meiotic drive elements with other classes of selfish genetic elements, including satellite DNAs, transposable elements, and with the endogenous host genes involved in drive suppression. Finally, we argue that some aspects of drive-mediated genome evolution are now sufficiently well established that we might reverse the direction of discovery—rather than ask how drive affects genome evolution, we can use genome data to discover new putative drive elements.","lang":"eng"}],"language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","day":"02","citation":{"ista":"Presgraves DC, Dawe RK, Dyer KA, Fishman L, Bhide SA, Bradshaw SL, Brady MJ, Burga A, Courret C, Fagen BL, Machado Ferretti ABS, Kelemen RK, Kitano J, Liu Y, Martí E, Erlenbach T, Reinhardt JA, Ross L, Runge JN, Swanepoel CM, Vicoso B, Vogan AA, Lindholm AK, Larracuente AM, Unckless RL. 2026. The evolutionary genomics of meiotic drive. Molecular Biology and Evolution. 43(2), msag020.","ama":"Presgraves DC, Dawe RK, Dyer KA, et al. The evolutionary genomics of meiotic drive. <i>Molecular Biology and Evolution</i>. 2026;43(2). doi:<a href=\"https://doi.org/10.1093/molbev/msag020\">10.1093/molbev/msag020</a>","chicago":"Presgraves, Daven C., R. Kelly Dawe, Kelly A. Dyer, Lila Fishman, Soumitra A. Bhide, Sasha L. Bradshaw, Meghan J. Brady, et al. “The Evolutionary Genomics of Meiotic Drive.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2026. <a href=\"https://doi.org/10.1093/molbev/msag020\">https://doi.org/10.1093/molbev/msag020</a>.","short":"D.C. Presgraves, R.K. Dawe, K.A. Dyer, L. Fishman, S.A. Bhide, S.L. Bradshaw, M.J. Brady, A. Burga, C. Courret, B.L. Fagen, A.B.S. Machado Ferretti, R.K. Kelemen, J. Kitano, Y. Liu, E. Martí, T. Erlenbach, J.A. Reinhardt, L. Ross, J.N. Runge, C.M. Swanepoel, B. Vicoso, A.A. Vogan, A.K. Lindholm, A.M. Larracuente, R.L. Unckless, Molecular Biology and Evolution 43 (2026).","ieee":"D. C. Presgraves <i>et al.</i>, “The evolutionary genomics of meiotic drive,” <i>Molecular Biology and Evolution</i>, vol. 43, no. 2. Oxford University Press, 2026.","mla":"Presgraves, Daven C., et al. “The Evolutionary Genomics of Meiotic Drive.” <i>Molecular Biology and Evolution</i>, vol. 43, no. 2, msag020, Oxford University Press, 2026, doi:<a href=\"https://doi.org/10.1093/molbev/msag020\">10.1093/molbev/msag020</a>.","apa":"Presgraves, D. C., Dawe, R. K., Dyer, K. A., Fishman, L., Bhide, S. A., Bradshaw, S. L., … Unckless, R. L. (2026). The evolutionary genomics of meiotic drive. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/molbev/msag020\">https://doi.org/10.1093/molbev/msag020</a>"},"has_accepted_license":"1","article_number":"msag020","intvolume":"        43","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["570"],"year":"2026","OA_place":"publisher","date_published":"2026-02-02T00:00:00Z","oa":1,"doi":"10.1093/molbev/msag020","acknowledgement":"This review is a product of the SMBE satellite workshop and the SNSF Scientific Exchange on the Genomic Consequences of Meiotic Drive. We thank the Society for Molecular Biology and Evolution (satellite grant to A.M.L., A.K.L., R.L.U., D.C.P.), the Swiss National Science Foundation (Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung IZSEZ0_217501 to A.K.L.), and the National Science Foundation Division of Molecular and Cellular Biosciences (NSF MCB Conference grant 2312190 to R.L.U.) for their generous support of the workshop.\r\n\r\nWe also thank the following for their support of individual authors: National Science Foundation Division of Molecular and Cellular Biosciences (NSF MCB CAREER 2047052 to R.L.U.), Division of Environmental Biology (NSF DEB-2344468 to L.F., NSF DEB-1737824 to K.A.D.), National Institute of General Medical Sciences (NIH R35GM119515 to A.M.L., NIH R01GM148442 to D.C.P.), European Research Council (PGErepro to L.R.), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP 2020/06188-5 to A.B.S.M.F.), Royal Society (DHF\\R1\\180120 to L.R.), Wissenschaftskolleg zu Berlin (support for D.C.P.), and Vetenskapsrådet (Swedish Research Council VR grant number 2021-0429 to A.A.V.).","author":[{"first_name":"Daven C.","last_name":"Presgraves","full_name":"Presgraves, Daven C."},{"full_name":"Dawe, R. Kelly","last_name":"Dawe","first_name":"R. Kelly"},{"last_name":"Dyer","full_name":"Dyer, Kelly A.","first_name":"Kelly A."},{"first_name":"Lila","last_name":"Fishman","full_name":"Fishman, Lila"},{"full_name":"Bhide, Soumitra A.","last_name":"Bhide","first_name":"Soumitra A."},{"first_name":"Sasha L.","last_name":"Bradshaw","full_name":"Bradshaw, Sasha L."},{"last_name":"Brady","full_name":"Brady, Meghan J.","first_name":"Meghan J."},{"first_name":"Alejandro","full_name":"Burga, Alejandro","last_name":"Burga"},{"first_name":"Cécile","full_name":"Courret, Cécile","last_name":"Courret"},{"full_name":"Fagen, Brandon L.","last_name":"Fagen","first_name":"Brandon L."},{"first_name":"Ana Beatriz Stein","full_name":"Machado Ferretti, Ana Beatriz Stein","last_name":"Machado Ferretti"},{"first_name":"Réka K","id":"48D3F8DE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8489-9281","full_name":"Kelemen, Réka K","last_name":"Kelemen"},{"first_name":"Jun","last_name":"Kitano","full_name":"Kitano, Jun"},{"full_name":"Liu, Yiran","last_name":"Liu","first_name":"Yiran"},{"last_name":"Martí","full_name":"Martí, Emiliano","first_name":"Emiliano"},{"first_name":"Theresa","full_name":"Erlenbach, Theresa","last_name":"Erlenbach"},{"full_name":"Reinhardt, Josephine A.","last_name":"Reinhardt","first_name":"Josephine A."},{"first_name":"Laura","last_name":"Ross","full_name":"Ross, Laura"},{"first_name":"Jan Niklas","last_name":"Runge","full_name":"Runge, Jan Niklas"},{"full_name":"Swanepoel, Callie M.","last_name":"Swanepoel","first_name":"Callie M."},{"orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","last_name":"Vicoso","full_name":"Vicoso, Beatriz"},{"first_name":"Aaron A.","full_name":"Vogan, Aaron A.","last_name":"Vogan"},{"first_name":"Anna K.","last_name":"Lindholm","full_name":"Lindholm, Anna K."},{"last_name":"Larracuente","full_name":"Larracuente, Amanda M.","first_name":"Amanda M."},{"full_name":"Unckless, Robert L.","last_name":"Unckless","first_name":"Robert L."}],"volume":43,"department":[{"_id":"BeVi"}],"month":"02","article_type":"original","article_processing_charge":"Yes","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publisher":"Oxford University Press","pmid":1,"publication_status":"published","file":[{"file_name":"2026_MolecularBioEvolution_Presgraves.pdf","checksum":"406e7cca0f2536d3bb877032fc837f9b","file_id":"21414","creator":"dernst","relation":"main_file","date_updated":"2026-03-09T10:32:02Z","access_level":"open_access","date_created":"2026-03-09T10:32:02Z","file_size":4533829,"content_type":"application/pdf","success":1}],"publication_identifier":{"eissn":["1537-1719"]},"title":"The evolutionary genomics of meiotic drive","date_created":"2026-03-08T23:01:45Z","OA_type":"gold","oa_version":"Published Version"},{"scopus_import":"1","DOAJ_listed":"1","status":"public","PlanS_conform":"1","publication":"Nature Communications","date_updated":"2025-12-15T09:28:37Z","file_date_updated":"2025-12-15T09:25:51Z","OA_place":"publisher","date_published":"2025-11-25T00:00:00Z","ddc":["570"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2025","intvolume":"        16","article_number":"10446","citation":{"chicago":"Paouneskou, Dimitra, Antoine Baudrimont, Réka K Kelemen, Marwan N Elkrewi, Angela Graf, Shehab Moukbel Ali Aldawla, Claudia Kölbl, Irene Tiemann-Boege, Beatriz Vicoso, and Verena Jantsch. “BAF-1–VRK-1 Mediated Release of Meiotic Chromosomes from the Nuclear Periphery Is Important for Genome Integrity.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-65420-9\">https://doi.org/10.1038/s41467-025-65420-9</a>.","ista":"Paouneskou D, Baudrimont A, Kelemen RK, Elkrewi MN, Graf A, Moukbel Ali Aldawla S, Kölbl C, Tiemann-Boege I, Vicoso B, Jantsch V. 2025. BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity. Nature Communications. 16, 10446.","ama":"Paouneskou D, Baudrimont A, Kelemen RK, et al. BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-65420-9\">10.1038/s41467-025-65420-9</a>","apa":"Paouneskou, D., Baudrimont, A., Kelemen, R. K., Elkrewi, M. N., Graf, A., Moukbel Ali Aldawla, S., … Jantsch, V. (2025). BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-65420-9\">https://doi.org/10.1038/s41467-025-65420-9</a>","ieee":"D. Paouneskou <i>et al.</i>, “BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","short":"D. Paouneskou, A. Baudrimont, R.K. Kelemen, M.N. Elkrewi, A. Graf, S. Moukbel Ali Aldawla, C. Kölbl, I. Tiemann-Boege, B. Vicoso, V. Jantsch, Nature Communications 16 (2025).","mla":"Paouneskou, Dimitra, et al. “BAF-1–VRK-1 Mediated Release of Meiotic Chromosomes from the Nuclear Periphery Is Important for Genome Integrity.” <i>Nature Communications</i>, vol. 16, 10446, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-65420-9\">10.1038/s41467-025-65420-9</a>."},"day":"25","has_accepted_license":"1","quality_controlled":"1","type":"journal_article","external_id":{"pmid":["41290579"]},"_id":"20796","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Rapid prophase chromosome movements ensure faithful alignment of the parental homologous chromosomes and successful synapsis formation during meiosis. These movements are driven by cytoplasmic forces transmitted to the nuclear periphery, where chromosome ends are attached through transmembrane proteins. During many developmental stages a specific genome architecture with chromatin nuclear periphery contacts mediates specific gene expression. Whether chromatin is removed from the nuclear periphery as a consequence of chromosome motions or by a specific mechanism is not fully understood. Here, we identify a mechanism to remove chromatin from the nuclear periphery through vaccinia related kinase (VRK-1)–dependent phosphorylation of Barrier to Autointegration Factor 1 (BAF-1) in Caenorhabditis elegans early prophase of meiosis. Interfering with chromatin removal delays chromosome pairing, impairs synapsis, produces oocytes with abnormal chromosomes and elevated apoptosis. Long read sequencing reveals deletions and duplications in offspring lacking VRK-1 underscoring the importance of the BAF-1–VRK-1 module in preserving genome stability in gametes during rapid chromosome movements."}],"pmid":1,"publisher":"Springer Nature","article_processing_charge":"Yes","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"department":[{"_id":"BeVi"}],"month":"11","article_type":"original","project":[{"_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396","grant_number":"F8810","name":"The highjacking of meiosis for asexual reproduction"}],"author":[{"first_name":"Dimitra","full_name":"Paouneskou, Dimitra","last_name":"Paouneskou"},{"full_name":"Baudrimont, Antoine","last_name":"Baudrimont","first_name":"Antoine"},{"last_name":"Kelemen","full_name":"Kelemen, Réka K","first_name":"Réka K","id":"48D3F8DE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8489-9281"},{"id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","first_name":"Marwan N","orcid":"0000-0002-5328-7231","full_name":"Elkrewi, Marwan N","last_name":"Elkrewi"},{"first_name":"Angela","last_name":"Graf","full_name":"Graf, Angela"},{"first_name":"Shehab","full_name":"Moukbel Ali Aldawla, Shehab","last_name":"Moukbel Ali Aldawla"},{"full_name":"Kölbl, Claudia","last_name":"Kölbl","first_name":"Claudia"},{"last_name":"Tiemann-Boege","full_name":"Tiemann-Boege, Irene","first_name":"Irene"},{"last_name":"Vicoso","full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz"},{"first_name":"Verena","full_name":"Jantsch, Verena","last_name":"Jantsch"}],"volume":16,"oa":1,"doi":"10.1038/s41467-025-65420-9","acknowledgement":"We are grateful to Monique Zetka, Nicola Silva, and Yumi Kim, Needhi Bhalla, George Krohne and Rueyling Lin for providing reagents; Scott Kennedy for sharing the multiplexed FISH library; and members of the Max Perutz Labs’ BioOptics facility (Irmgard Fischer, Josef Gotzmann, Thomas Peterbauer, Clara Bodner, and Nick Wedige) for training and support in image acquisition. We also thank the members of the NGS facility at the Vienna Biocenter. This work was funded by the Austrian Science Fund (FWF) SFB projects F 8805-B (VJ), https://doi.org/10.55776/F88, F 8809-B (ITB), and F8810-B (BV). We are also grateful to members of the V. Jantsch laboratory for helpful discussions. Some strains were provided by the Caenorhabditis Genetics Center, which is funded by the National Institutes of Health Office of Research Infrastructure Programs (P40OD010440).","OA_type":"gold","oa_version":"Published Version","title":"BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity","date_created":"2025-12-11T10:45:06Z","publication_identifier":{"eissn":["2041-1723"]},"file":[{"file_size":8096309,"date_created":"2025-12-15T09:25:51Z","success":1,"content_type":"application/pdf","access_level":"open_access","date_updated":"2025-12-15T09:25:51Z","creator":"dernst","relation":"main_file","file_id":"20823","file_name":"2025_NatureComm_Paouneskou.pdf","checksum":"a952f7ea050242b79008540de49a0e61"}],"publication_status":"published"},{"file_date_updated":"2025-01-10T23:30:10Z","date_updated":"2026-04-07T13:21:37Z","status":"public","page":"105","ec_funded":1,"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","type":"dissertation","_id":"17119","language":[{"iso":"eng"}],"abstract":[{"text":"Genomes are shaped by natural selection at the level of the organism, as genomic variants that\r\nhave a beneficial effect on the viability or fecundity of their carriers are on average expected\r\nto be passed on to more offspring than less beneficial alleles. However, selection also favors\r\ngenomic variants that drive their own transmission to the next generation above the mendelian\r\nexpectation of 50 percent in heterozygotes, even if these self-promoting variants are less\r\nbeneficial to the organism than other variants at the same locus. Such variants, called meiotic\r\ndrivers, are found in diverse taxa, and often impose fitness costs on their host organisms. As\r\nmeiotic drivers often require multiple genes and sequences for transmission ratio distortion,\r\nthey are often found in regions of low recombination, such as inversions, which prevent their\r\nrecombination with the non-driving homologous regions. Reduced recombination rates are\r\nexpected to lead to the accumulation of deleterious mutations, which may affect hundreds\r\nof genes trapped in the inversions of meiotic drivers. Although the observed fitness costs of\r\nself-promoting haplotypes are thought to possibly reflect sequence degeneration, no study has\r\nsystematically investigated the level of degeneration on a meiotic driver. Further, the low\r\nrates of recombination between driving and non-driving haplotypes have limited the power of\r\ntraditional genetic studies in uncovering the gene content of meiotic drivers, and made the\r\nthe identification of the genes causing transmission ratio distortion difficult.\r\nAfter an introduction to meiotic drivers in Chapter 1, this thesis presents three studies that\r\nmake use of next generation sequencing data to characterize the sequence and expression\r\nevolution of genes on the t-haplotype, a large and ancient meiotic driver in house mice that is\r\ntransmitted to up to 100% of the offspring in males heterozygous for it. Chapter 2 presents\r\na comprehensive assessment of the t-haplotype’s sequence evolution, which shows signs of\r\nsequence degeneration counteracted by occasional recombination with the non-driving homolog\r\nover large parts of the meiotic driver, proposing an explanation for its long-term survival.\r\nChapter 3 investigates the sequence and expression evolution of genes on the t-haplotype,\r\nand finds widespread expression and copy number changes and signs of less efficient purifying\r\nselection compared to the genes on the non-driving homolog. Further, this chapter finds\r\ncandidates for involvment in drive: two positively selected genes on the t-haplotype, and\r\nthe discovery of a t-specific gene duplicate, which was gained from another chromosome,\r\nand which acquired novel sequence and testis-specific expression on the t-haplotype. Finally,\r\nChapter 4 provides unprecedented insights into the gene expression landscape in testes of\r\nt-carrier mice, using single nucleus sequencing. Cell-resolved RNA-sequencing allows the\r\ncomparison of expression in spermatids carrying or not carrying the t-haplotype as well as the\r\ntiming of t-haplotype-induced expression changes along spermatogenesis. This study shows\r\nthe timing of previously found drive-associated genes, and uncovers novel candidate genes and\r\nbiological processes that may underlie the complex biology of transmission ratio distortion of\r\nthe t-haplotype. Chapter 5 synthesizes the findings of the three studies, and discusses them in\r\nthe context of the current state of meiotic drive research.","lang":"eng"}],"has_accepted_license":"1","citation":{"chicago":"Kelemen, Réka K. “Characterizing the Sequence and Expression Evolution of the T-Haplotype, a Model Meiotic Driver.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:17119\">https://doi.org/10.15479/at:ista:17119</a>.","ama":"Kelemen RK. Characterizing the sequence and expression evolution of the t-haplotype, a model meiotic driver. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:17119\">10.15479/at:ista:17119</a>","ista":"Kelemen RK. 2024. Characterizing the sequence and expression evolution of the t-haplotype, a model meiotic driver. Institute of Science and Technology Austria.","apa":"Kelemen, R. K. (2024). <i>Characterizing the sequence and expression evolution of the t-haplotype, a model meiotic driver</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:17119\">https://doi.org/10.15479/at:ista:17119</a>","mla":"Kelemen, Réka K. <i>Characterizing the Sequence and Expression Evolution of the T-Haplotype, a Model Meiotic Driver</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:17119\">10.15479/at:ista:17119</a>.","ieee":"R. K. Kelemen, “Characterizing the sequence and expression evolution of the t-haplotype, a model meiotic driver,” Institute of Science and Technology Austria, 2024.","short":"R.K. Kelemen, Characterizing the Sequence and Expression Evolution of the T-Haplotype, a Model Meiotic Driver, Institute of Science and Technology Austria, 2024."},"day":"20","year":"2024","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","ddc":["576"],"date_published":"2024-06-20T00:00:00Z","OA_place":"publisher","degree_awarded":"PhD","oa":1,"doi":"10.15479/at:ista:17119","project":[{"call_identifier":"H2020","_id":"250BDE62-B435-11E9-9278-68D0E5697425","grant_number":"715257","name":"Prevalence and Influence of Sexual Antagonism on Genome Evolution"},{"grant_number":"F8810","_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396","name":"The highjacking of meiosis for asexual reproduction"}],"month":"06","department":[{"_id":"GradSch"},{"_id":"BeVi"}],"author":[{"orcid":"0000-0002-8489-9281","id":"48D3F8DE-F248-11E8-B48F-1D18A9856A87","first_name":"Réka K","full_name":"Kelemen, Réka K","last_name":"Kelemen"}],"publisher":"Institute of Science and Technology Austria","corr_author":"1","tmp":{"short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"article_processing_charge":"No","related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"542"},{"relation":"part_of_dissertation","status":"public","id":"10767"}]},"publication_status":"published","supervisor":[{"full_name":"Vicoso, Beatriz","last_name":"Vicoso","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","orcid":"0000-0002-4579-8306"}],"file":[{"file_id":"17121","creator":"rkelemen","date_updated":"2025-01-10T23:30:10Z","relation":"source_file","file_name":"thesis.zip","checksum":"fab59146e3b3dc2e5d214576984a2a63","embargo_to":"open_access","date_created":"2024-06-07T16:09:17Z","file_size":180557931,"content_type":"application/zip","access_level":"closed"},{"checksum":"91cc4c25a792239e8a7688e8aec7c62a","file_name":"thesis_to_archive.pdf","relation":"main_file","creator":"rkelemen","date_updated":"2025-01-10T23:30:10Z","file_id":"17213","embargo":"2025-01-10","access_level":"open_access","content_type":"application/pdf","date_created":"2024-07-10T08:00:20Z","file_size":19405484}],"publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-039-8"]},"keyword":["meiotic driver","neofunctionalization","single nucleus sequencing"],"oa_version":"Published Version","title":"Characterizing the sequence and expression evolution of the t-haplotype, a model meiotic driver","date_created":"2024-06-07T16:14:13Z","alternative_title":["ISTA Thesis"]},{"related_material":{"record":[{"id":"17119","status":"public","relation":"dissertation_contains"},{"status":"public","id":"19386","relation":"dissertation_contains"}]},"pmid":1,"article_processing_charge":"No","corr_author":"1","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publisher":"The Royal Society","volume":289,"author":[{"orcid":"0000-0002-8489-9281","id":"48D3F8DE-F248-11E8-B48F-1D18A9856A87","first_name":"Réka K","last_name":"Kelemen","full_name":"Kelemen, Réka K"},{"last_name":"Elkrewi","full_name":"Elkrewi, Marwan N","orcid":"0000-0002-5328-7231","id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","first_name":"Marwan N"},{"first_name":"Anna K.","full_name":"Lindholm, Anna K.","last_name":"Lindholm"},{"last_name":"Vicoso","full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz"}],"department":[{"_id":"BeVi"}],"month":"02","article_type":"original","project":[{"name":"Prevalence and Influence of Sexual Antagonism on Genome Evolution","call_identifier":"H2020","_id":"250BDE62-B435-11E9-9278-68D0E5697425","grant_number":"715257"}],"doi":"10.1098/rspb.2021.1985","oa":1,"acknowledgement":"This project has received funding from the European Research Council under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 715257) and from the Swiss National Science Foundation (grant no. 310030_189145).\r\nWe thank Jari Garbely of the Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland, for conducting the PCR verification. Barbara\r\nKonig, Gabi Stichel and A.K.L. collected mouse tissue samples, from the field study led by R.K.K. ","title":"Novel patterns of expression and recruitment of new genes on the t-haplotype, a mouse selfish chromosome","date_created":"2022-02-20T23:01:31Z","oa_version":"Published Version","publication_identifier":{"eissn":["1471-2954"]},"file":[{"checksum":"27042a3706ae52a919fed1ac114bf7bb","file_name":"2022_ProceedingsRoyalSocB_Kelemen.pdf","creator":"dernst","file_id":"10779","relation":"main_file","date_updated":"2022-02-21T08:17:38Z","access_level":"open_access","success":1,"content_type":"application/pdf","file_size":2366976,"date_created":"2022-02-21T08:17:38Z"}],"publication_status":"published","issue":"1968","ec_funded":1,"scopus_import":"1","status":"public","page":"20211985","publication":"Proceedings of the Royal Society B: Biological Sciences","date_updated":"2026-04-27T22:31:03Z","isi":1,"file_date_updated":"2022-02-21T08:17:38Z","date_published":"2022-02-09T00:00:00Z","intvolume":"       289","ddc":["570"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2022","citation":{"short":"R.K. Kelemen, M.N. Elkrewi, A.K. Lindholm, B. Vicoso, Proceedings of the Royal Society B: Biological Sciences 289 (2022) 20211985.","ieee":"R. K. Kelemen, M. N. Elkrewi, A. K. Lindholm, and B. Vicoso, “Novel patterns of expression and recruitment of new genes on the t-haplotype, a mouse selfish chromosome,” <i>Proceedings of the Royal Society B: Biological Sciences</i>, vol. 289, no. 1968. The Royal Society, p. 20211985, 2022.","mla":"Kelemen, Réka K., et al. “Novel Patterns of Expression and Recruitment of New Genes on the T-Haplotype, a Mouse Selfish Chromosome.” <i>Proceedings of the Royal Society B: Biological Sciences</i>, vol. 289, no. 1968, The Royal Society, 2022, p. 20211985, doi:<a href=\"https://doi.org/10.1098/rspb.2021.1985\">10.1098/rspb.2021.1985</a>.","apa":"Kelemen, R. K., Elkrewi, M. N., Lindholm, A. K., &#38; Vicoso, B. (2022). Novel patterns of expression and recruitment of new genes on the t-haplotype, a mouse selfish chromosome. <i>Proceedings of the Royal Society B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rspb.2021.1985\">https://doi.org/10.1098/rspb.2021.1985</a>","ista":"Kelemen RK, Elkrewi MN, Lindholm AK, Vicoso B. 2022. Novel patterns of expression and recruitment of new genes on the t-haplotype, a mouse selfish chromosome. Proceedings of the Royal Society B: Biological Sciences. 289(1968), 20211985.","ama":"Kelemen RK, Elkrewi MN, Lindholm AK, Vicoso B. Novel patterns of expression and recruitment of new genes on the t-haplotype, a mouse selfish chromosome. <i>Proceedings of the Royal Society B: Biological Sciences</i>. 2022;289(1968):20211985. doi:<a href=\"https://doi.org/10.1098/rspb.2021.1985\">10.1098/rspb.2021.1985</a>","chicago":"Kelemen, Réka K, Marwan N Elkrewi, Anna K. Lindholm, and Beatriz Vicoso. “Novel Patterns of Expression and Recruitment of New Genes on the T-Haplotype, a Mouse Selfish Chromosome.” <i>Proceedings of the Royal Society B: Biological Sciences</i>. The Royal Society, 2022. <a href=\"https://doi.org/10.1098/rspb.2021.1985\">https://doi.org/10.1098/rspb.2021.1985</a>."},"day":"09","has_accepted_license":"1","external_id":{"pmid":["35135349"],"isi":["000752812800012"]},"abstract":[{"lang":"eng","text":"The t-haplotype of mice is a classical model for autosomal transmission distortion. A largely non-recombining variant of the proximal region of chromosome 17, it is transmitted to more than 90% of the progeny of heterozygous males through the disabling of sperm carrying a standard chromosome. While extensive genetic and functional work has shed light on individual genes involved in drive, much less is known about the evolution and function of the rest of its hundreds of genes. Here, we characterize the sequence and expression of dozens of t-specific transcripts and of their chromosome 17 homologues. Many genes showed reduced expression of the t-allele, but an equal number of genes showed increased expression of their t-copy, consistent with increased activity or a newly evolved function. Genes on the t-haplotype had a significantly higher non-synonymous substitution rate than their homologues on the standard chromosome, with several genes harbouring dN/dS ratios above 1. Finally, the t-haplotype has acquired at least two genes from other chromosomes, which show high and tissue-specific expression. These results provide a first overview of the gene content of this selfish element, and support a more dynamic evolutionary scenario than expected of a large genomic region with almost no recombination."}],"_id":"10767","language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article"},{"file":[{"content_type":"application/pdf","date_created":"2019-11-04T15:54:00Z","file_size":2083061,"access_level":"open_access","creator":"dernst","file_id":"6984","date_updated":"2020-07-14T12:47:46Z","relation":"main_file","checksum":"68d1708f7aa412544159b498ef17a6b9","file_name":"2019_FrontiersImmonology_Kelemen.pdf"}],"publication_status":"published","oa_version":"Published Version","title":"Clustering of activated CD8 T cells around Malaria-infected hepatocytes is rapid and is driven by antigen-specific cells","date_created":"2019-11-04T15:50:06Z","publication_identifier":{"issn":["1664-3224"]},"department":[{"_id":"BeVi"}],"month":"09","article_type":"original","author":[{"orcid":"0000-0002-8489-9281","first_name":"Réka K","id":"48D3F8DE-F248-11E8-B48F-1D18A9856A87","full_name":"Kelemen, Réka K","last_name":"Kelemen"},{"last_name":"Rajakaruna","full_name":"Rajakaruna, H","first_name":"H"},{"first_name":"IA","full_name":"Cockburn, IA","last_name":"Cockburn"},{"full_name":"Ganusov, VV","last_name":"Ganusov","first_name":"VV"}],"volume":10,"doi":"10.3389/fimmu.2019.02153","oa":1,"pmid":1,"publisher":"Frontiers","article_processing_charge":"No","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"citation":{"mla":"Kelemen, Réka K., et al. “Clustering of Activated CD8 T Cells around Malaria-Infected Hepatocytes Is Rapid and Is Driven by Antigen-Specific Cells.” <i>Frontiers in Immunology</i>, vol. 10, 2153, Frontiers, 2019, doi:<a href=\"https://doi.org/10.3389/fimmu.2019.02153\">10.3389/fimmu.2019.02153</a>.","short":"R.K. Kelemen, H. Rajakaruna, I. Cockburn, V. Ganusov, Frontiers in Immunology 10 (2019).","ieee":"R. K. Kelemen, H. Rajakaruna, I. Cockburn, and V. Ganusov, “Clustering of activated CD8 T cells around Malaria-infected hepatocytes is rapid and is driven by antigen-specific cells,” <i>Frontiers in Immunology</i>, vol. 10. Frontiers, 2019.","apa":"Kelemen, R. K., Rajakaruna, H., Cockburn, I., &#38; Ganusov, V. (2019). Clustering of activated CD8 T cells around Malaria-infected hepatocytes is rapid and is driven by antigen-specific cells. <i>Frontiers in Immunology</i>. Frontiers. <a href=\"https://doi.org/10.3389/fimmu.2019.02153\">https://doi.org/10.3389/fimmu.2019.02153</a>","ama":"Kelemen RK, Rajakaruna H, Cockburn I, Ganusov V. Clustering of activated CD8 T cells around Malaria-infected hepatocytes is rapid and is driven by antigen-specific cells. <i>Frontiers in Immunology</i>. 2019;10. doi:<a href=\"https://doi.org/10.3389/fimmu.2019.02153\">10.3389/fimmu.2019.02153</a>","ista":"Kelemen RK, Rajakaruna H, Cockburn I, Ganusov V. 2019. Clustering of activated CD8 T cells around Malaria-infected hepatocytes is rapid and is driven by antigen-specific cells. Frontiers in Immunology. 10, 2153.","chicago":"Kelemen, Réka K, H Rajakaruna, IA Cockburn, and VV Ganusov. “Clustering of Activated CD8 T Cells around Malaria-Infected Hepatocytes Is Rapid and Is Driven by Antigen-Specific Cells.” <i>Frontiers in Immunology</i>. Frontiers, 2019. <a href=\"https://doi.org/10.3389/fimmu.2019.02153\">https://doi.org/10.3389/fimmu.2019.02153</a>."},"day":"20","has_accepted_license":"1","quality_controlled":"1","type":"journal_article","external_id":{"pmid":["31616407"],"isi":["000487187000001"]},"language":[{"iso":"eng"}],"_id":"6983","abstract":[{"text":"Malaria, a disease caused by parasites of the Plasmodium genus, begins when Plasmodium-infected mosquitoes inject malaria sporozoites while searching for blood. Sporozoites migrate from the skin via blood to the liver, infect hepatocytes, and form liver stages which in mice 48 h later escape into blood and cause clinical malaria. Vaccine-induced activated or memory CD8 T cells are capable of locating and eliminating all liver stages in 48 h, thus preventing the blood-stage disease. However, the rules of how CD8 T cells are able to locate all liver stages within a relatively short time period remains poorly understood. We recently reported formation of clusters consisting of variable numbers of activated CD8 T cells around Plasmodium yoelii (Py)-infected hepatocytes. Using a combination of experimental data and mathematical models we now provide additional insights into mechanisms of formation of these clusters. First, we show that a model in which cluster formation is driven exclusively by T-cell-extrinsic factors, such as variability in “attractiveness” of different liver stages, cannot explain distribution of cluster sizes in different experimental conditions. In contrast, the model in which cluster formation is driven by the positive feedback loop (i.e., larger clusters attract more CD8 T cells) can accurately explain the available data. Second, while both Py-specific CD8 T cells and T cells of irrelevant specificity (non-specific CD8 T cells) are attracted to the clusters, we found no evidence that non-specific CD8 T cells play a role in cluster formation. Third and finally, mathematical modeling suggested that formation of clusters occurs rapidly, within few hours after adoptive transfer of CD8 T cells, thus illustrating high efficiency of CD8 T cells in locating their targets in complex peripheral organs, such as the liver. Taken together, our analysis provides novel insights into and attempts to discriminate between alternative mechanisms driving the formation of clusters of antigen-specific CD8 T cells in the liver.","lang":"eng"}],"date_published":"2019-09-20T00:00:00Z","ddc":["570"],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","year":"2019","intvolume":"        10","article_number":"2153","isi":1,"publication":"Frontiers in Immunology","date_updated":"2023-08-30T07:18:23Z","file_date_updated":"2020-07-14T12:47:46Z","scopus_import":"1","status":"public"},{"file_date_updated":"2020-07-14T12:46:50Z","isi":1,"date_updated":"2026-04-27T22:30:16Z","publication":"Genetics","status":"public","page":"365 - 375","scopus_import":"1","issue":"1","ec_funded":1,"quality_controlled":"1","type":"journal_article","external_id":{"isi":["000419356300024"]},"language":[{"iso":"eng"}],"_id":"542","abstract":[{"lang":"eng","text":"The t-haplotype, a mouse meiotic driver found on chromosome 17, has been a model for autosomal segregation distortion for close to a century, but several questions remain regarding its biology and evolutionary history. A recently published set of population genomics resources for wild mice includes several individuals heterozygous for the t-haplotype, which we use to characterize this selfish element at the genomic and transcriptomic level. Our results show that large sections of the t-haplotype have been replaced by standard homologous sequences, possibly due to occasional events of recombination, and that this complicates the inference of its history. As expected for a long genomic segment of very low recombination, the t-haplotype carries an excess of fixed nonsynonymous mutations compared to the standard chromosome. This excess is stronger for regions that have not undergone recent recombination, suggesting that occasional gene flow between the t and the standard chromosome may provide a mechanism to regenerate coding sequences that have accumulated deleterious mutations. Finally, we find that t-complex genes with altered expression largely overlap with deleted or amplified regions, and that carrying a t-haplotype alters the testis expression of genes outside of the t-complex, providing new leads into the pathways involved in the biology of this segregation distorter."}],"citation":{"chicago":"Kelemen, Réka K, and Beatriz Vicoso. “Complex History and Differentiation Patterns of the T-Haplotype, a Mouse Meiotic Driver.” <i>Genetics</i>. Genetics Society of America, 2018. <a href=\"https://doi.org/10.1534/genetics.117.300513\">https://doi.org/10.1534/genetics.117.300513</a>.","ama":"Kelemen RK, Vicoso B. Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver. <i>Genetics</i>. 2018;208(1):365-375. doi:<a href=\"https://doi.org/10.1534/genetics.117.300513\">10.1534/genetics.117.300513</a>","ista":"Kelemen RK, Vicoso B. 2018. Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver. Genetics. 208(1), 365–375.","apa":"Kelemen, R. K., &#38; Vicoso, B. (2018). Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.117.300513\">https://doi.org/10.1534/genetics.117.300513</a>","mla":"Kelemen, Réka K., and Beatriz Vicoso. “Complex History and Differentiation Patterns of the T-Haplotype, a Mouse Meiotic Driver.” <i>Genetics</i>, vol. 208, no. 1, Genetics Society of America, 2018, pp. 365–75, doi:<a href=\"https://doi.org/10.1534/genetics.117.300513\">10.1534/genetics.117.300513</a>.","short":"R.K. Kelemen, B. Vicoso, Genetics 208 (2018) 365–375.","ieee":"R. K. Kelemen and B. Vicoso, “Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver,” <i>Genetics</i>, vol. 208, no. 1. Genetics Society of America, pp. 365–375, 2018."},"day":"01","has_accepted_license":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","ddc":["576"],"year":"2018","intvolume":"       208","date_published":"2018-01-01T00:00:00Z","pubrep_id":"1058","doi":"10.1534/genetics.117.300513","oa":1,"month":"01","department":[{"_id":"BeVi"}],"project":[{"name":"Prevalence and Influence of Sexual Antagonism on Genome Evolution","_id":"250BDE62-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"715257"}],"article_type":"original","author":[{"full_name":"Kelemen, Réka K","last_name":"Kelemen","id":"48D3F8DE-F248-11E8-B48F-1D18A9856A87","first_name":"Réka K","orcid":"0000-0002-8489-9281"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","orcid":"0000-0002-4579-8306","full_name":"Vicoso, Beatriz","last_name":"Vicoso"}],"volume":208,"publisher":"Genetics Society of America","article_processing_charge":"No","corr_author":"1","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"related_material":{"record":[{"relation":"popular_science","status":"public","id":"5571"},{"id":"5572","status":"public","relation":"popular_science"},{"id":"17119","status":"public","relation":"dissertation_contains"}]},"publication_status":"published","publist_id":"7274","file":[{"creator":"system","date_updated":"2020-07-14T12:46:50Z","file_id":"5132","relation":"main_file","checksum":"2123845e7031a0cf043905be160f9e69","file_name":"IST-2018-1058-v1+1_365.full__1_.pdf","content_type":"application/pdf","file_size":1311661,"date_created":"2018-12-12T10:15:14Z","access_level":"open_access"}],"oa_version":"Published Version","date_created":"2018-12-11T11:47:04Z","title":"Complex history and differentiation patterns of the t-haplotype, a mouse meiotic driver"}]