---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21409'
abstract:
- lang: eng
text: Meiotic drivers are selfish genetic elements that gain transmission advantages
by distorting equal, Mendelian segregation. For decades, biologists have considered
meiotic drivers as interesting, albeit esoteric, case studies. It is now clear,
however, that meiotic drive is more common and phylogenetically widespread than
previously supposed. Indeed, intensive study of a few well-known cases has begun
to reveal the evolutionary genomic consequences of meiotic drive. We argue here
that many features of genome evolution, content, and organization that are seemingly
inexplicable by organismal adaptation or nearly neutral processes are instead
best accounted for by recurrent histories of meiotic drive. We review how meiotic
drive can affect the evolution of sequences, gene copy numbers, genes with functions
in meiosis and gametogenesis, signatures of “selection,” chromosome rearrangements,
and karyotype evolution. We also explore the interactions of meiotic drive elements
with other classes of selfish genetic elements, including satellite DNAs, transposable
elements, and with the endogenous host genes involved in drive suppression. Finally,
we argue that some aspects of drive-mediated genome evolution are now sufficiently
well established that we might reverse the direction of discovery—rather than
ask how drive affects genome evolution, we can use genome data to discover new
putative drive elements.
acknowledgement: "This review is a product of the SMBE satellite workshop and the
SNSF Scientific Exchange on the Genomic Consequences of Meiotic Drive. We thank
the Society for Molecular Biology and Evolution (satellite grant to A.M.L., A.K.L.,
R.L.U., D.C.P.), the Swiss National Science Foundation (Schweizerischer Nationalfonds
zur Förderung der Wissenschaftlichen Forschung IZSEZ0_217501 to A.K.L.), and the
National Science Foundation Division of Molecular and Cellular Biosciences (NSF
MCB Conference grant 2312190 to R.L.U.) for their generous support of the workshop.\r\n\r\nWe
also thank the following for their support of individual authors: National Science
Foundation Division of Molecular and Cellular Biosciences (NSF MCB CAREER 2047052
to R.L.U.), Division of Environmental Biology (NSF DEB-2344468 to L.F., NSF DEB-1737824
to K.A.D.), National Institute of General Medical Sciences (NIH R35GM119515 to A.M.L.,
NIH R01GM148442 to D.C.P.), European Research Council (PGErepro to L.R.), Fundação
de Amparo à Pesquisa do Estado de São Paulo (FAPESP 2020/06188-5 to A.B.S.M.F.),
Royal Society (DHF\\R1\\180120 to L.R.), Wissenschaftskolleg zu Berlin (support
for D.C.P.), and Vetenskapsrådet (Swedish Research Council VR grant number 2021-0429
to A.A.V.)."
article_number: msag020
article_processing_charge: Yes
article_type: original
author:
- first_name: Daven C.
full_name: Presgraves, Daven C.
last_name: Presgraves
- first_name: R. Kelly
full_name: Dawe, R. Kelly
last_name: Dawe
- first_name: Kelly A.
full_name: Dyer, Kelly A.
last_name: Dyer
- first_name: Lila
full_name: Fishman, Lila
last_name: Fishman
- first_name: Soumitra A.
full_name: Bhide, Soumitra A.
last_name: Bhide
- first_name: Sasha L.
full_name: Bradshaw, Sasha L.
last_name: Bradshaw
- first_name: Meghan J.
full_name: Brady, Meghan J.
last_name: Brady
- first_name: Alejandro
full_name: Burga, Alejandro
last_name: Burga
- first_name: Cécile
full_name: Courret, Cécile
last_name: Courret
- first_name: Brandon L.
full_name: Fagen, Brandon L.
last_name: Fagen
- first_name: Ana Beatriz Stein
full_name: Machado Ferretti, Ana Beatriz Stein
last_name: Machado Ferretti
- first_name: Réka K
full_name: Kelemen, Réka K
id: 48D3F8DE-F248-11E8-B48F-1D18A9856A87
last_name: Kelemen
orcid: 0000-0002-8489-9281
- first_name: Jun
full_name: Kitano, Jun
last_name: Kitano
- first_name: Yiran
full_name: Liu, Yiran
last_name: Liu
- first_name: Emiliano
full_name: Martí, Emiliano
last_name: Martí
- first_name: Theresa
full_name: Erlenbach, Theresa
last_name: Erlenbach
- first_name: Josephine A.
full_name: Reinhardt, Josephine A.
last_name: Reinhardt
- first_name: Laura
full_name: Ross, Laura
last_name: Ross
- first_name: Jan Niklas
full_name: Runge, Jan Niklas
last_name: Runge
- first_name: Callie M.
full_name: Swanepoel, Callie M.
last_name: Swanepoel
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
- first_name: Aaron A.
full_name: Vogan, Aaron A.
last_name: Vogan
- first_name: Anna K.
full_name: Lindholm, Anna K.
last_name: Lindholm
- first_name: Amanda M.
full_name: Larracuente, Amanda M.
last_name: Larracuente
- first_name: Robert L.
full_name: Unckless, Robert L.
last_name: Unckless
citation:
ama: Presgraves DC, Dawe RK, Dyer KA, et al. The evolutionary genomics of meiotic
drive. Molecular Biology and Evolution. 2026;43(2). doi:10.1093/molbev/msag020
apa: Presgraves, D. C., Dawe, R. K., Dyer, K. A., Fishman, L., Bhide, S. A., Bradshaw,
S. L., … Unckless, R. L. (2026). The evolutionary genomics of meiotic drive. Molecular
Biology and Evolution. Oxford University Press. https://doi.org/10.1093/molbev/msag020
chicago: Presgraves, Daven C., R. Kelly Dawe, Kelly A. Dyer, Lila Fishman, Soumitra
A. Bhide, Sasha L. Bradshaw, Meghan J. Brady, et al. “The Evolutionary Genomics
of Meiotic Drive.” Molecular Biology and Evolution. Oxford University Press,
2026. https://doi.org/10.1093/molbev/msag020.
ieee: D. C. Presgraves et al., “The evolutionary genomics of meiotic drive,”
Molecular Biology and Evolution, vol. 43, no. 2. Oxford University Press,
2026.
ista: Presgraves DC, Dawe RK, Dyer KA, Fishman L, Bhide SA, Bradshaw SL, Brady MJ,
Burga A, Courret C, Fagen BL, Machado Ferretti ABS, Kelemen RK, Kitano J, Liu
Y, Martí E, Erlenbach T, Reinhardt JA, Ross L, Runge JN, Swanepoel CM, Vicoso
B, Vogan AA, Lindholm AK, Larracuente AM, Unckless RL. 2026. The evolutionary
genomics of meiotic drive. Molecular Biology and Evolution. 43(2), msag020.
mla: Presgraves, Daven C., et al. “The Evolutionary Genomics of Meiotic Drive.”
Molecular Biology and Evolution, vol. 43, no. 2, msag020, Oxford University
Press, 2026, doi:10.1093/molbev/msag020.
short: D.C. Presgraves, R.K. Dawe, K.A. Dyer, L. Fishman, S.A. Bhide, S.L. Bradshaw,
M.J. Brady, A. Burga, C. Courret, B.L. Fagen, A.B.S. Machado Ferretti, R.K. Kelemen,
J. Kitano, Y. Liu, E. Martí, T. Erlenbach, J.A. Reinhardt, L. Ross, J.N. Runge,
C.M. Swanepoel, B. Vicoso, A.A. Vogan, A.K. Lindholm, A.M. Larracuente, R.L. Unckless,
Molecular Biology and Evolution 43 (2026).
date_created: 2026-03-08T23:01:45Z
date_published: 2026-02-02T00:00:00Z
date_updated: 2026-03-09T10:33:04Z
day: '02'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/molbev/msag020
external_id:
pmid:
- '41589062'
file:
- access_level: open_access
checksum: 406e7cca0f2536d3bb877032fc837f9b
content_type: application/pdf
creator: dernst
date_created: 2026-03-09T10:32:02Z
date_updated: 2026-03-09T10:32:02Z
file_id: '21414'
file_name: 2026_MolecularBioEvolution_Presgraves.pdf
file_size: 4533829
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success: 1
file_date_updated: 2026-03-09T10:32:02Z
has_accepted_license: '1'
intvolume: ' 43'
issue: '2'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Molecular Biology and Evolution
publication_identifier:
eissn:
- 1537-1719
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: The evolutionary genomics of meiotic drive
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20796'
abstract:
- lang: eng
text: Rapid prophase chromosome movements ensure faithful alignment of the parental
homologous chromosomes and successful synapsis formation during meiosis. These
movements are driven by cytoplasmic forces transmitted to the nuclear periphery,
where chromosome ends are attached through transmembrane proteins. During many
developmental stages a specific genome architecture with chromatin nuclear periphery
contacts mediates specific gene expression. Whether chromatin is removed from
the nuclear periphery as a consequence of chromosome motions or by a specific
mechanism is not fully understood. Here, we identify a mechanism to remove chromatin
from the nuclear periphery through vaccinia related kinase (VRK-1)–dependent phosphorylation
of Barrier to Autointegration Factor 1 (BAF-1) in Caenorhabditis elegans early
prophase of meiosis. Interfering with chromatin removal delays chromosome pairing,
impairs synapsis, produces oocytes with abnormal chromosomes and elevated apoptosis.
Long read sequencing reveals deletions and duplications in offspring lacking VRK-1
underscoring the importance of the BAF-1–VRK-1 module in preserving genome stability
in gametes during rapid chromosome movements.
acknowledgement: We are grateful to Monique Zetka, Nicola Silva, and Yumi Kim, Needhi
Bhalla, George Krohne and Rueyling Lin for providing reagents; Scott Kennedy for
sharing the multiplexed FISH library; and members of the Max Perutz Labs’ BioOptics
facility (Irmgard Fischer, Josef Gotzmann, Thomas Peterbauer, Clara Bodner, and
Nick Wedige) for training and support in image acquisition. We also thank the members
of the NGS facility at the Vienna Biocenter. This work was funded by the Austrian
Science Fund (FWF) SFB projects F 8805-B (VJ), https://doi.org/10.55776/F88, F 8809-B
(ITB), and F8810-B (BV). We are also grateful to members of the V. Jantsch laboratory
for helpful discussions. Some strains were provided by the Caenorhabditis Genetics
Center, which is funded by the National Institutes of Health Office of Research
Infrastructure Programs (P40OD010440).
article_number: '10446'
article_processing_charge: Yes
article_type: original
author:
- first_name: Dimitra
full_name: Paouneskou, Dimitra
last_name: Paouneskou
- first_name: Antoine
full_name: Baudrimont, Antoine
last_name: Baudrimont
- first_name: Réka K
full_name: Kelemen, Réka K
id: 48D3F8DE-F248-11E8-B48F-1D18A9856A87
last_name: Kelemen
orcid: 0000-0002-8489-9281
- first_name: Marwan N
full_name: Elkrewi, Marwan N
id: 0B46FACA-A8E1-11E9-9BD3-79D1E5697425
last_name: Elkrewi
orcid: 0000-0002-5328-7231
- first_name: Angela
full_name: Graf, Angela
last_name: Graf
- first_name: Shehab
full_name: Moukbel Ali Aldawla, Shehab
last_name: Moukbel Ali Aldawla
- first_name: Claudia
full_name: Kölbl, Claudia
last_name: Kölbl
- first_name: Irene
full_name: Tiemann-Boege, Irene
last_name: Tiemann-Boege
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
- first_name: Verena
full_name: Jantsch, Verena
last_name: Jantsch
citation:
ama: Paouneskou D, Baudrimont A, Kelemen RK, et al. BAF-1–VRK-1 mediated release
of meiotic chromosomes from the nuclear periphery is important for genome integrity.
Nature Communications. 2025;16. doi:10.1038/s41467-025-65420-9
apa: Paouneskou, D., Baudrimont, A., Kelemen, R. K., Elkrewi, M. N., Graf, A., Moukbel
Ali Aldawla, S., … Jantsch, V. (2025). BAF-1–VRK-1 mediated release of meiotic
chromosomes from the nuclear periphery is important for genome integrity. Nature
Communications. Springer Nature. https://doi.org/10.1038/s41467-025-65420-9
chicago: Paouneskou, Dimitra, Antoine Baudrimont, Réka K Kelemen, Marwan N Elkrewi,
Angela Graf, Shehab Moukbel Ali Aldawla, Claudia Kölbl, Irene Tiemann-Boege, Beatriz
Vicoso, and Verena Jantsch. “BAF-1–VRK-1 Mediated Release of Meiotic Chromosomes
from the Nuclear Periphery Is Important for Genome Integrity.” Nature Communications.
Springer Nature, 2025. https://doi.org/10.1038/s41467-025-65420-9.
ieee: D. Paouneskou et al., “BAF-1–VRK-1 mediated release of meiotic chromosomes
from the nuclear periphery is important for genome integrity,” Nature Communications,
vol. 16. Springer Nature, 2025.
ista: Paouneskou D, Baudrimont A, Kelemen RK, Elkrewi MN, Graf A, Moukbel Ali Aldawla
S, Kölbl C, Tiemann-Boege I, Vicoso B, Jantsch V. 2025. BAF-1–VRK-1 mediated release
of meiotic chromosomes from the nuclear periphery is important for genome integrity.
Nature Communications. 16, 10446.
mla: Paouneskou, Dimitra, et al. “BAF-1–VRK-1 Mediated Release of Meiotic Chromosomes
from the Nuclear Periphery Is Important for Genome Integrity.” Nature Communications,
vol. 16, 10446, Springer Nature, 2025, doi:10.1038/s41467-025-65420-9.
short: D. Paouneskou, A. Baudrimont, R.K. Kelemen, M.N. Elkrewi, A. Graf, S. Moukbel
Ali Aldawla, C. Kölbl, I. Tiemann-Boege, B. Vicoso, V. Jantsch, Nature Communications
16 (2025).
date_created: 2025-12-11T10:45:06Z
date_published: 2025-11-25T00:00:00Z
date_updated: 2025-12-15T09:28:37Z
day: '25'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1038/s41467-025-65420-9
external_id:
pmid:
- '41290579'
file:
- access_level: open_access
checksum: a952f7ea050242b79008540de49a0e61
content_type: application/pdf
creator: dernst
date_created: 2025-12-15T09:25:51Z
date_updated: 2025-12-15T09:25:51Z
file_id: '20823'
file_name: 2025_NatureComm_Paouneskou.pdf
file_size: 8096309
relation: main_file
success: 1
file_date_updated: 2025-12-15T09:25:51Z
has_accepted_license: '1'
intvolume: ' 16'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 34ae1506-11ca-11ed-8bc3-c14f4c474396
grant_number: F8810
name: The highjacking of meiosis for asexual reproduction
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery
is important for genome integrity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
OA_place: publisher
_id: '17119'
abstract:
- lang: eng
text: "Genomes are shaped by natural selection at the level of the organism, as
genomic variants that\r\nhave a beneficial effect on the viability or fecundity
of their carriers are on average expected\r\nto be passed on to more offspring
than less beneficial alleles. However, selection also favors\r\ngenomic variants
that drive their own transmission to the next generation above the mendelian\r\nexpectation
of 50 percent in heterozygotes, even if these self-promoting variants are less\r\nbeneficial
to the organism than other variants at the same locus. Such variants, called meiotic\r\ndrivers,
are found in diverse taxa, and often impose fitness costs on their host organisms.
As\r\nmeiotic drivers often require multiple genes and sequences for transmission
ratio distortion,\r\nthey are often found in regions of low recombination, such
as inversions, which prevent their\r\nrecombination with the non-driving homologous
regions. Reduced recombination rates are\r\nexpected to lead to the accumulation
of deleterious mutations, which may affect hundreds\r\nof genes trapped in the
inversions of meiotic drivers. Although the observed fitness costs of\r\nself-promoting
haplotypes are thought to possibly reflect sequence degeneration, no study has\r\nsystematically
investigated the level of degeneration on a meiotic driver. Further, the low\r\nrates
of recombination between driving and non-driving haplotypes have limited the power
of\r\ntraditional genetic studies in uncovering the gene content of meiotic drivers,
and made the\r\nthe identification of the genes causing transmission ratio distortion
difficult.\r\nAfter an introduction to meiotic drivers in Chapter 1, this thesis
presents three studies that\r\nmake use of next generation sequencing data to
characterize the sequence and expression\r\nevolution of genes on the t-haplotype,
a large and ancient meiotic driver in house mice that is\r\ntransmitted to up
to 100% of the offspring in males heterozygous for it. Chapter 2 presents\r\na
comprehensive assessment of the t-haplotype’s sequence evolution, which shows
signs of\r\nsequence degeneration counteracted by occasional recombination with
the non-driving homolog\r\nover large parts of the meiotic driver, proposing an
explanation for its long-term survival.\r\nChapter 3 investigates the sequence
and expression evolution of genes on the t-haplotype,\r\nand finds widespread
expression and copy number changes and signs of less efficient purifying\r\nselection
compared to the genes on the non-driving homolog. Further, this chapter finds\r\ncandidates
for involvment in drive: two positively selected genes on the t-haplotype, and\r\nthe
discovery of a t-specific gene duplicate, which was gained from another chromosome,\r\nand
which acquired novel sequence and testis-specific expression on the t-haplotype.
Finally,\r\nChapter 4 provides unprecedented insights into the gene expression
landscape in testes of\r\nt-carrier mice, using single nucleus sequencing. Cell-resolved
RNA-sequencing allows the\r\ncomparison of expression in spermatids carrying or
not carrying the t-haplotype as well as the\r\ntiming of t-haplotype-induced expression
changes along spermatogenesis. This study shows\r\nthe timing of previously found
drive-associated genes, and uncovers novel candidate genes and\r\nbiological processes
that may underlie the complex biology of transmission ratio distortion of\r\nthe
t-haplotype. Chapter 5 synthesizes the findings of the three studies, and discusses
them in\r\nthe context of the current state of meiotic drive research."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Réka K
full_name: Kelemen, Réka K
id: 48D3F8DE-F248-11E8-B48F-1D18A9856A87
last_name: Kelemen
orcid: 0000-0002-8489-9281
citation:
ama: Kelemen RK. Characterizing the sequence and expression evolution of the t-haplotype,
a model meiotic driver. 2024. doi:10.15479/at:ista:17119
apa: Kelemen, R. K. (2024). Characterizing the sequence and expression evolution
of the t-haplotype, a model meiotic driver. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:17119
chicago: Kelemen, Réka K. “Characterizing the Sequence and Expression Evolution
of the T-Haplotype, a Model Meiotic Driver.” Institute of Science and Technology
Austria, 2024. https://doi.org/10.15479/at:ista:17119.
ieee: R. K. Kelemen, “Characterizing the sequence and expression evolution of the
t-haplotype, a model meiotic driver,” Institute of Science and Technology Austria,
2024.
ista: Kelemen RK. 2024. Characterizing the sequence and expression evolution of
the t-haplotype, a model meiotic driver. Institute of Science and Technology Austria.
mla: Kelemen, Réka K. Characterizing the Sequence and Expression Evolution of
the T-Haplotype, a Model Meiotic Driver. Institute of Science and Technology
Austria, 2024, doi:10.15479/at:ista:17119.
short: R.K. Kelemen, Characterizing the Sequence and Expression Evolution of the
T-Haplotype, a Model Meiotic Driver, Institute of Science and Technology Austria,
2024.
corr_author: '1'
date_created: 2024-06-07T16:14:13Z
date_published: 2024-06-20T00:00:00Z
date_updated: 2026-04-07T13:21:37Z
day: '20'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: GradSch
- _id: BeVi
doi: 10.15479/at:ista:17119
ec_funded: 1
file:
- access_level: closed
checksum: fab59146e3b3dc2e5d214576984a2a63
content_type: application/zip
creator: rkelemen
date_created: 2024-06-07T16:09:17Z
date_updated: 2025-01-10T23:30:10Z
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file_id: '17121'
file_name: thesis.zip
file_size: 180557931
relation: source_file
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content_type: application/pdf
creator: rkelemen
date_created: 2024-07-10T08:00:20Z
date_updated: 2025-01-10T23:30:10Z
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file_id: '17213'
file_name: thesis_to_archive.pdf
file_size: 19405484
relation: main_file
file_date_updated: 2025-01-10T23:30:10Z
has_accepted_license: '1'
keyword:
- meiotic driver
- neofunctionalization
- single nucleus sequencing
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '06'
oa: 1
oa_version: Published Version
page: '105'
project:
- _id: 250BDE62-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715257'
name: Prevalence and Influence of Sexual Antagonism on Genome Evolution
- _id: 34ae1506-11ca-11ed-8bc3-c14f4c474396
grant_number: F8810
name: The highjacking of meiosis for asexual reproduction
publication_identifier:
isbn:
- 978-3-99078-039-8
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '542'
relation: part_of_dissertation
status: public
- id: '10767'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
title: Characterizing the sequence and expression evolution of the t-haplotype, a
model meiotic driver
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2024'
...
---
_id: '10767'
abstract:
- lang: eng
text: The t-haplotype of mice is a classical model for autosomal transmission distortion.
A largely non-recombining variant of the proximal region of chromosome 17, it
is transmitted to more than 90% of the progeny of heterozygous males through the
disabling of sperm carrying a standard chromosome. While extensive genetic and
functional work has shed light on individual genes involved in drive, much less
is known about the evolution and function of the rest of its hundreds of genes.
Here, we characterize the sequence and expression of dozens of t-specific transcripts
and of their chromosome 17 homologues. Many genes showed reduced expression of
the t-allele, but an equal number of genes showed increased expression of their
t-copy, consistent with increased activity or a newly evolved function. Genes
on the t-haplotype had a significantly higher non-synonymous substitution rate
than their homologues on the standard chromosome, with several genes harbouring
dN/dS ratios above 1. Finally, the t-haplotype has acquired at least two genes
from other chromosomes, which show high and tissue-specific expression. These
results provide a first overview of the gene content of this selfish element,
and support a more dynamic evolutionary scenario than expected of a large genomic
region with almost no recombination.
acknowledgement: "This project has received funding from the European Research Council
under the European Union’s Horizon 2020 research and innovation program (grant agreement
no. 715257) and from the Swiss National Science Foundation (grant no. 310030_189145).\r\nWe
thank Jari Garbely of the Department of Evolutionary Biology and Environmental Studies,
University of Zurich, Zurich, Switzerland, for conducting the PCR verification.
Barbara\r\nKonig, Gabi Stichel and A.K.L. collected mouse tissue samples, from the
field study led by R.K.K. "
article_processing_charge: No
article_type: original
author:
- first_name: Réka K
full_name: Kelemen, Réka K
id: 48D3F8DE-F248-11E8-B48F-1D18A9856A87
last_name: Kelemen
orcid: 0000-0002-8489-9281
- first_name: Marwan N
full_name: Elkrewi, Marwan N
id: 0B46FACA-A8E1-11E9-9BD3-79D1E5697425
last_name: Elkrewi
orcid: 0000-0002-5328-7231
- first_name: Anna K.
full_name: Lindholm, Anna K.
last_name: Lindholm
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: 'Kelemen RK, Elkrewi MN, Lindholm AK, Vicoso B. Novel patterns of expression
and recruitment of new genes on the t-haplotype, a mouse selfish chromosome. Proceedings
of the Royal Society B: Biological Sciences. 2022;289(1968):20211985. doi:10.1098/rspb.2021.1985'
apa: 'Kelemen, R. K., Elkrewi, M. N., Lindholm, A. K., & Vicoso, B. (2022).
Novel patterns of expression and recruitment of new genes on the t-haplotype,
a mouse selfish chromosome. Proceedings of the Royal Society B: Biological
Sciences. The Royal Society. https://doi.org/10.1098/rspb.2021.1985'
chicago: 'Kelemen, Réka K, Marwan N Elkrewi, Anna K. Lindholm, and Beatriz Vicoso.
“Novel Patterns of Expression and Recruitment of New Genes on the T-Haplotype,
a Mouse Selfish Chromosome.” Proceedings of the Royal Society B: Biological
Sciences. The Royal Society, 2022. https://doi.org/10.1098/rspb.2021.1985.'
ieee: 'R. K. Kelemen, M. N. Elkrewi, A. K. Lindholm, and B. Vicoso, “Novel patterns
of expression and recruitment of new genes on the t-haplotype, a mouse selfish
chromosome,” Proceedings of the Royal Society B: Biological Sciences, vol.
289, no. 1968. The Royal Society, p. 20211985, 2022.'
ista: 'Kelemen RK, Elkrewi MN, Lindholm AK, Vicoso B. 2022. Novel patterns of expression
and recruitment of new genes on the t-haplotype, a mouse selfish chromosome. Proceedings
of the Royal Society B: Biological Sciences. 289(1968), 20211985.'
mla: 'Kelemen, Réka K., et al. “Novel Patterns of Expression and Recruitment of
New Genes on the T-Haplotype, a Mouse Selfish Chromosome.” Proceedings of the
Royal Society B: Biological Sciences, vol. 289, no. 1968, The Royal Society,
2022, p. 20211985, doi:10.1098/rspb.2021.1985.'
short: 'R.K. Kelemen, M.N. Elkrewi, A.K. Lindholm, B. Vicoso, Proceedings of the
Royal Society B: Biological Sciences 289 (2022) 20211985.'
corr_author: '1'
date_created: 2022-02-20T23:01:31Z
date_published: 2022-02-09T00:00:00Z
date_updated: 2026-08-03T22:30:30Z
day: '09'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1098/rspb.2021.1985
ec_funded: 1
external_id:
isi:
- '000752812800012'
pmid:
- '35135349'
file:
- access_level: open_access
checksum: 27042a3706ae52a919fed1ac114bf7bb
content_type: application/pdf
creator: dernst
date_created: 2022-02-21T08:17:38Z
date_updated: 2022-02-21T08:17:38Z
file_id: '10779'
file_name: 2022_ProceedingsRoyalSocB_Kelemen.pdf
file_size: 2366976
relation: main_file
success: 1
file_date_updated: 2022-02-21T08:17:38Z
has_accepted_license: '1'
intvolume: ' 289'
isi: 1
issue: '1968'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '20211985'
pmid: 1
project:
- _id: 250BDE62-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715257'
name: Prevalence and Influence of Sexual Antagonism on Genome Evolution
publication: 'Proceedings of the Royal Society B: Biological Sciences'
publication_identifier:
eissn:
- 1471-2954
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
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record:
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relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Novel patterns of expression and recruitment of new genes on the t-haplotype,
a mouse selfish chromosome
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 289
year: '2022'
...
---
_id: '6983'
abstract:
- lang: eng
text: Malaria, a disease caused by parasites of the Plasmodium genus, begins when
Plasmodium-infected mosquitoes inject malaria sporozoites while searching for
blood. Sporozoites migrate from the skin via blood to the liver, infect hepatocytes,
and form liver stages which in mice 48 h later escape into blood and cause clinical
malaria. Vaccine-induced activated or memory CD8 T cells are capable of locating
and eliminating all liver stages in 48 h, thus preventing the blood-stage disease.
However, the rules of how CD8 T cells are able to locate all liver stages within
a relatively short time period remains poorly understood. We recently reported
formation of clusters consisting of variable numbers of activated CD8 T cells
around Plasmodium yoelii (Py)-infected hepatocytes. Using a combination of experimental
data and mathematical models we now provide additional insights into mechanisms
of formation of these clusters. First, we show that a model in which cluster formation
is driven exclusively by T-cell-extrinsic factors, such as variability in “attractiveness”
of different liver stages, cannot explain distribution of cluster sizes in different
experimental conditions. In contrast, the model in which cluster formation is
driven by the positive feedback loop (i.e., larger clusters attract more CD8 T
cells) can accurately explain the available data. Second, while both Py-specific
CD8 T cells and T cells of irrelevant specificity (non-specific CD8 T cells) are
attracted to the clusters, we found no evidence that non-specific CD8 T cells
play a role in cluster formation. Third and finally, mathematical modeling suggested
that formation of clusters occurs rapidly, within few hours after adoptive transfer
of CD8 T cells, thus illustrating high efficiency of CD8 T cells in locating their
targets in complex peripheral organs, such as the liver. Taken together, our analysis
provides novel insights into and attempts to discriminate between alternative
mechanisms driving the formation of clusters of antigen-specific CD8 T cells in
the liver.
article_number: '2153'
article_processing_charge: No
article_type: original
author:
- first_name: Réka K
full_name: Kelemen, Réka K
id: 48D3F8DE-F248-11E8-B48F-1D18A9856A87
last_name: Kelemen
orcid: 0000-0002-8489-9281
- first_name: H
full_name: Rajakaruna, H
last_name: Rajakaruna
- first_name: IA
full_name: Cockburn, IA
last_name: Cockburn
- first_name: VV
full_name: Ganusov, VV
last_name: Ganusov
citation:
ama: Kelemen RK, Rajakaruna H, Cockburn I, Ganusov V. Clustering of activated CD8
T cells around Malaria-infected hepatocytes is rapid and is driven by antigen-specific
cells. Frontiers in Immunology. 2019;10. doi:10.3389/fimmu.2019.02153
apa: Kelemen, R. K., Rajakaruna, H., Cockburn, I., & Ganusov, V. (2019). Clustering
of activated CD8 T cells around Malaria-infected hepatocytes is rapid and is driven
by antigen-specific cells. Frontiers in Immunology. Frontiers. https://doi.org/10.3389/fimmu.2019.02153
chicago: Kelemen, Réka K, H Rajakaruna, IA Cockburn, and VV Ganusov. “Clustering
of Activated CD8 T Cells around Malaria-Infected Hepatocytes Is Rapid and Is Driven
by Antigen-Specific Cells.” Frontiers in Immunology. Frontiers, 2019. https://doi.org/10.3389/fimmu.2019.02153.
ieee: R. K. Kelemen, H. Rajakaruna, I. Cockburn, and V. Ganusov, “Clustering of
activated CD8 T cells around Malaria-infected hepatocytes is rapid and is driven
by antigen-specific cells,” Frontiers in Immunology, vol. 10. Frontiers,
2019.
ista: Kelemen RK, Rajakaruna H, Cockburn I, Ganusov V. 2019. Clustering of activated
CD8 T cells around Malaria-infected hepatocytes is rapid and is driven by antigen-specific
cells. Frontiers in Immunology. 10, 2153.
mla: Kelemen, Réka K., et al. “Clustering of Activated CD8 T Cells around Malaria-Infected
Hepatocytes Is Rapid and Is Driven by Antigen-Specific Cells.” Frontiers in
Immunology, vol. 10, 2153, Frontiers, 2019, doi:10.3389/fimmu.2019.02153.
short: R.K. Kelemen, H. Rajakaruna, I. Cockburn, V. Ganusov, Frontiers in Immunology
10 (2019).
date_created: 2019-11-04T15:50:06Z
date_published: 2019-09-20T00:00:00Z
date_updated: 2023-08-30T07:18:23Z
day: '20'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.3389/fimmu.2019.02153
external_id:
isi:
- '000487187000001'
pmid:
- '31616407'
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- access_level: open_access
checksum: 68d1708f7aa412544159b498ef17a6b9
content_type: application/pdf
creator: dernst
date_created: 2019-11-04T15:54:00Z
date_updated: 2020-07-14T12:47:46Z
file_id: '6984'
file_name: 2019_FrontiersImmonology_Kelemen.pdf
file_size: 2083061
relation: main_file
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intvolume: ' 10'
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language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
publication: Frontiers in Immunology
publication_identifier:
issn:
- 1664-3224
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Clustering of activated CD8 T cells around Malaria-infected hepatocytes is
rapid and is driven by antigen-specific cells
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2019'
...
---
_id: '542'
abstract:
- lang: eng
text: The t-haplotype, a mouse meiotic driver found on chromosome 17, has been a
model for autosomal segregation distortion for close to a century, but several
questions remain regarding its biology and evolutionary history. A recently published
set of population genomics resources for wild mice includes several individuals
heterozygous for the t-haplotype, which we use to characterize this selfish element
at the genomic and transcriptomic level. Our results show that large sections
of the t-haplotype have been replaced by standard homologous sequences, possibly
due to occasional events of recombination, and that this complicates the inference
of its history. As expected for a long genomic segment of very low recombination,
the t-haplotype carries an excess of fixed nonsynonymous mutations compared to
the standard chromosome. This excess is stronger for regions that have not undergone
recent recombination, suggesting that occasional gene flow between the t and the
standard chromosome may provide a mechanism to regenerate coding sequences that
have accumulated deleterious mutations. Finally, we find that t-complex genes
with altered expression largely overlap with deleted or amplified regions, and
that carrying a t-haplotype alters the testis expression of genes outside of the
t-complex, providing new leads into the pathways involved in the biology of this
segregation distorter.
article_processing_charge: No
article_type: original
author:
- first_name: Réka K
full_name: Kelemen, Réka K
id: 48D3F8DE-F248-11E8-B48F-1D18A9856A87
last_name: Kelemen
orcid: 0000-0002-8489-9281
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: Kelemen RK, Vicoso B. Complex history and differentiation patterns of the t-haplotype,
a mouse meiotic driver. Genetics. 2018;208(1):365-375. doi:10.1534/genetics.117.300513
apa: Kelemen, R. K., & Vicoso, B. (2018). Complex history and differentiation
patterns of the t-haplotype, a mouse meiotic driver. Genetics. Genetics
Society of America. https://doi.org/10.1534/genetics.117.300513
chicago: Kelemen, Réka K, and Beatriz Vicoso. “Complex History and Differentiation
Patterns of the T-Haplotype, a Mouse Meiotic Driver.” Genetics. Genetics
Society of America, 2018. https://doi.org/10.1534/genetics.117.300513.
ieee: R. K. Kelemen and B. Vicoso, “Complex history and differentiation patterns
of the t-haplotype, a mouse meiotic driver,” Genetics, vol. 208, no. 1.
Genetics Society of America, pp. 365–375, 2018.
ista: Kelemen RK, Vicoso B. 2018. Complex history and differentiation patterns of
the t-haplotype, a mouse meiotic driver. Genetics. 208(1), 365–375.
mla: Kelemen, Réka K., and Beatriz Vicoso. “Complex History and Differentiation
Patterns of the T-Haplotype, a Mouse Meiotic Driver.” Genetics, vol. 208,
no. 1, Genetics Society of America, 2018, pp. 365–75, doi:10.1534/genetics.117.300513.
short: R.K. Kelemen, B. Vicoso, Genetics 208 (2018) 365–375.
corr_author: '1'
date_created: 2018-12-11T11:47:04Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2026-08-03T22:30:30Z
day: '01'
ddc:
- '576'
department:
- _id: BeVi
doi: 10.1534/genetics.117.300513
ec_funded: 1
external_id:
isi:
- '000419356300024'
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checksum: 2123845e7031a0cf043905be160f9e69
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date_created: 2018-12-12T10:15:14Z
date_updated: 2020-07-14T12:46:50Z
file_id: '5132'
file_name: IST-2018-1058-v1+1_365.full__1_.pdf
file_size: 1311661
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file_date_updated: 2020-07-14T12:46:50Z
has_accepted_license: '1'
intvolume: ' 208'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 365 - 375
project:
- _id: 250BDE62-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715257'
name: Prevalence and Influence of Sexual Antagonism on Genome Evolution
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '7274'
pubrep_id: '1058'
quality_controlled: '1'
related_material:
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status: public
- id: '5572'
relation: popular_science
status: public
- id: '17119'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Complex history and differentiation patterns of the t-haplotype, a mouse meiotic
driver
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 208
year: '2018'
...