[{"publication_status":"published","date_updated":"2025-09-30T13:47:45Z","scopus_import":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"doi":"10.1088/1367-2630/ade61b","OA_place":"publisher","external_id":{"isi":["001517731700001"]},"DOAJ_listed":"1","title":"Multiple ionic memories in asymmetric nanochannels revealed by mem-spectrometry","abstract":[{"lang":"eng","text":"Recently discovered nanofluidic memristors, have raised promises for the development of iontronics and neuromorphic computing with ions. Ionic memory effects are related to ion dynamics inside nanochannels, with timescales associated with the manifold physicochemical phenomena occurring at confined interfaces. Here, we explore experimentally the frequency-dependent current–voltage response of model nanochannels—namely glass nanopipettes—to investigate memory effects in ion transport. This characterisation, which we refer to as mem-spectrometry, highlights two characteristic frequencies, associated with short and long timescales of the order of 50 ms and 50 s in the present system. Whereas the former can be associated with ionic diffusion, very long timescales are difficult to explain with conventional transport phenomena. We develop a minimal model accounting for these mem-spectrometry results, pointing to surface charge regulation and ionic adsorption-desorption as possible origins for the long-term memory. Our work demonstrates the relevance of mem-spectrometry to highlight subtle ion transport properties in nanochannels, giving hereby new insights on the mechanisms governing ion transport and current rectification in charged conical nanopores."}],"isi":1,"ddc":["530"],"month":"06","publication":"New Journal of Physics","date_created":"2025-07-06T22:01:23Z","oa":1,"intvolume":"        27","author":[{"full_name":"Jouveshomme, Simon","last_name":"Jouveshomme","first_name":"Simon"},{"full_name":"Lizée, Mathieu","last_name":"Lizée","first_name":"Mathieu"},{"last_name":"Robin","full_name":"Robin, Paul","orcid":"0000-0002-5728-9189","first_name":"Paul","id":"48c58128-57b0-11ee-9095-dc28fd97fc1d"},{"first_name":"Lydéric","last_name":"Bocquet","full_name":"Bocquet, Lydéric"}],"_id":"19966","article_processing_charge":"Yes","publisher":"IOP Publishing","year":"2025","day":"01","date_published":"2025-06-01T00:00:00Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"EdHa"}],"acknowledgement":"The authors acknowledge ERC n-AQUA for funding. S J acknowledges CNRS for funding. The authors thank Hummink for pipette supply and characterization. P R acknowledges funding from the European Union Horizon 2020 research and innovation program under the Marie Skodowska-Curie Grant Agreement No. 101034413.","volume":27,"file_date_updated":"2025-07-08T06:11:59Z","file":[{"relation":"main_file","file_id":"19973","success":1,"creator":"dernst","checksum":"e0e11aa01c54b20ee6cdd1f6b999571f","content_type":"application/pdf","file_name":"2025_NewJourPhysics_Jouveshomme.pdf","date_created":"2025-07-08T06:11:59Z","file_size":1296141,"date_updated":"2025-07-08T06:11:59Z","access_level":"open_access"}],"license":"https://creativecommons.org/licenses/by/4.0/","ec_funded":1,"status":"public","issue":"6","article_number":"065001","publication_identifier":{"eissn":["1367-2630"]},"has_accepted_license":"1","type":"journal_article","quality_controlled":"1","project":[{"grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020"}],"OA_type":"gold","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"original","citation":{"ieee":"S. Jouveshomme, M. Lizée, P. Robin, and L. Bocquet, “Multiple ionic memories in asymmetric nanochannels revealed by mem-spectrometry,” <i>New Journal of Physics</i>, vol. 27, no. 6. IOP Publishing, 2025.","apa":"Jouveshomme, S., Lizée, M., Robin, P., &#38; Bocquet, L. (2025). Multiple ionic memories in asymmetric nanochannels revealed by mem-spectrometry. <i>New Journal of Physics</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1367-2630/ade61b\">https://doi.org/10.1088/1367-2630/ade61b</a>","short":"S. Jouveshomme, M. Lizée, P. Robin, L. Bocquet, New Journal of Physics 27 (2025).","chicago":"Jouveshomme, Simon, Mathieu Lizée, Paul Robin, and Lydéric Bocquet. “Multiple Ionic Memories in Asymmetric Nanochannels Revealed by Mem-Spectrometry.” <i>New Journal of Physics</i>. IOP Publishing, 2025. <a href=\"https://doi.org/10.1088/1367-2630/ade61b\">https://doi.org/10.1088/1367-2630/ade61b</a>.","ista":"Jouveshomme S, Lizée M, Robin P, Bocquet L. 2025. Multiple ionic memories in asymmetric nanochannels revealed by mem-spectrometry. New Journal of Physics. 27(6), 065001.","ama":"Jouveshomme S, Lizée M, Robin P, Bocquet L. Multiple ionic memories in asymmetric nanochannels revealed by mem-spectrometry. <i>New Journal of Physics</i>. 2025;27(6). doi:<a href=\"https://doi.org/10.1088/1367-2630/ade61b\">10.1088/1367-2630/ade61b</a>","mla":"Jouveshomme, Simon, et al. “Multiple Ionic Memories in Asymmetric Nanochannels Revealed by Mem-Spectrometry.” <i>New Journal of Physics</i>, vol. 27, no. 6, 065001, IOP Publishing, 2025, doi:<a href=\"https://doi.org/10.1088/1367-2630/ade61b\">10.1088/1367-2630/ade61b</a>."}},{"oa":1,"date_created":"2025-11-23T23:01:40Z","publication":"Nature Nanotechnology","month":"11","isi":1,"external_id":{"isi":["001611698900001"],"pmid":["41219410"]},"title":"Lumen charge governs gated ion transport in β-barrel nanopores","abstract":[{"lang":"eng","text":"β-Barrel nanopores are involved in crucial biological processes, from ATP export in mitochondria to bacterial resistance, and represent a promising platform for emerging sequencing technologies. However, in contrast to ion channels, the understanding of the fundamental principles governing ion transport through these nanopores remains largely unexplored. Here we integrate experimental, numerical and theoretical approaches to elucidate ion transport mechanisms in β-barrel nanopores. We identify and characterize two distinct nonlinear phenomena: open-pore rectification and gating. Through extensive mutation analysis of aerolysin nanopores, we demonstrate that open-pore rectification is caused by ionic accumulation driven by the distribution of lumen charges. In addition, we provide converging evidence suggesting that gating is controlled by electric fields dissociating counterions from lumen charges, promoting local structural deformations. Our findings establish a rigorous framework for characterizing and understanding ion transport processes in protein-based nanopores, enabling the design of adaptable nanofluidic biotechnologies. We illustrate this by optimizing an aerolysin mutant for computing applications."}],"OA_place":"publisher","doi":"10.1038/s41565-025-02052-6","language":[{"iso":"eng"}],"oa_version":"Published Version","date_updated":"2025-12-01T15:20:40Z","publication_status":"epub_ahead","scopus_import":"1","OA_type":"hybrid","article_type":"original","citation":{"ista":"Mayer S, Mitsioni MF, Robin P, Van Den Heuvel L, Ronceray N, Marcaida MJ, Abriata LA, Krapp LF, Anton JS, Soussou S, Jeanneret-Grosjean J, Fulciniti A, Möller A, Vacle S, Feletti L, Brinkerhoff H, Laszlo AH, Gundlach JH, Emmerich T, Dal Peraro M, Radenovic A. 2025. Lumen charge governs gated ion transport in β-barrel nanopores. Nature Nanotechnology.","ama":"Mayer S, Mitsioni MF, Robin P, et al. Lumen charge governs gated ion transport in β-barrel nanopores. <i>Nature Nanotechnology</i>. 2025. doi:<a href=\"https://doi.org/10.1038/s41565-025-02052-6\">10.1038/s41565-025-02052-6</a>","ieee":"S. Mayer <i>et al.</i>, “Lumen charge governs gated ion transport in β-barrel nanopores,” <i>Nature Nanotechnology</i>. Springer Nature, 2025.","apa":"Mayer, S., Mitsioni, M. F., Robin, P., Van Den Heuvel, L., Ronceray, N., Marcaida, M. J., … Radenovic, A. (2025). Lumen charge governs gated ion transport in β-barrel nanopores. <i>Nature Nanotechnology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41565-025-02052-6\">https://doi.org/10.1038/s41565-025-02052-6</a>","chicago":"Mayer, Simon, Marianna Fanouria Mitsioni, Paul Robin, Lukas Van Den Heuvel, Nathan Ronceray, Maria Jose Marcaida, Luciano A. Abriata, et al. “Lumen Charge Governs Gated Ion Transport in β-Barrel Nanopores.” <i>Nature Nanotechnology</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41565-025-02052-6\">https://doi.org/10.1038/s41565-025-02052-6</a>.","short":"S. Mayer, M.F. Mitsioni, P. Robin, L. Van Den Heuvel, N. Ronceray, M.J. Marcaida, L.A. Abriata, L.F. Krapp, J.S. Anton, S. Soussou, J. Jeanneret-Grosjean, A. Fulciniti, A. Möller, S. Vacle, L. Feletti, H. Brinkerhoff, A.H. Laszlo, J.H. Gundlach, T. Emmerich, M. Dal Peraro, A. Radenovic, Nature Nanotechnology (2025).","mla":"Mayer, Simon, et al. “Lumen Charge Governs Gated Ion Transport in β-Barrel Nanopores.” <i>Nature Nanotechnology</i>, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41565-025-02052-6\">10.1038/s41565-025-02052-6</a>."},"pmid":1,"quality_controlled":"1","type":"journal_article","PlanS_conform":"1","publication_identifier":{"eissn":["1748-3395"],"issn":["1748-3387"]},"main_file_link":[{"url":"https://doi.org/10.1038/s41565-025-02052-6","open_access":"1"}],"status":"public","acknowledgement":"We are grateful to M. Mayer and G. van der Goot for their insightful discussions and thoughtful feedback. We acknowledge funding from the European Research Council (grants 101020445—2D-LIQUID N.R. and A.R., MSCA number 101034413 P.R.), the Swiss National Science Foundation (grants 205321_192371 and 200021L_212128 to M.D.P., TMPFP2-217134 to T.E., and IZSEZ0_183779 to J.H.G. and A.R.) and the Swiss National Supercomputing Centre (CSCS) for access to the HPC resources used to run MD simulations. We thank the staff members of the Dubochet Center for Imaging in Lausanne, in particular E. Uchikawa and S. Nazarov, for their assistance with cryo-EM sample preparation and data collection. We thank A. Antanasijevic and Y. Duhoo from EPFL Protein Production and Structure Core Facility for their support in cryo-EM data processing.","date_published":"2025-11-11T00:00:00Z","day":"11","year":"2025","department":[{"_id":"EdHa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"20670","article_processing_charge":"Yes (in subscription journal)","author":[{"first_name":"Simon","full_name":"Mayer, Simon","last_name":"Mayer"},{"first_name":"Marianna Fanouria","full_name":"Mitsioni, Marianna Fanouria","last_name":"Mitsioni"},{"last_name":"Robin","full_name":"Robin, Paul","orcid":"0000-0002-5728-9189","id":"48c58128-57b0-11ee-9095-dc28fd97fc1d","first_name":"Paul"},{"full_name":"Van Den Heuvel, Lukas","last_name":"Van Den Heuvel","first_name":"Lukas"},{"first_name":"Nathan","last_name":"Ronceray","full_name":"Ronceray, Nathan"},{"first_name":"Maria Jose","last_name":"Marcaida","full_name":"Marcaida, Maria Jose"},{"last_name":"Abriata","full_name":"Abriata, Luciano A.","first_name":"Luciano A."},{"first_name":"Lucien F.","full_name":"Krapp, Lucien F.","last_name":"Krapp"},{"first_name":"Jana S.","full_name":"Anton, Jana S.","last_name":"Anton"},{"first_name":"Sarah","full_name":"Soussou, Sarah","last_name":"Soussou"},{"first_name":"Justin","full_name":"Jeanneret-Grosjean, Justin","last_name":"Jeanneret-Grosjean"},{"first_name":"Alessandro","last_name":"Fulciniti","full_name":"Fulciniti, Alessandro"},{"last_name":"Möller","full_name":"Möller, Alexia","first_name":"Alexia"},{"full_name":"Vacle, Sarah","last_name":"Vacle","first_name":"Sarah"},{"first_name":"Lely","full_name":"Feletti, Lely","last_name":"Feletti"},{"full_name":"Brinkerhoff, Henry","last_name":"Brinkerhoff","first_name":"Henry"},{"first_name":"Andrew H.","full_name":"Laszlo, Andrew H.","last_name":"Laszlo"},{"first_name":"Jens H.","full_name":"Gundlach, Jens H.","last_name":"Gundlach"},{"first_name":"Theo","last_name":"Emmerich","full_name":"Emmerich, Theo"},{"first_name":"Matteo","last_name":"Dal Peraro","full_name":"Dal Peraro, Matteo"},{"full_name":"Radenovic, Aleksandra","last_name":"Radenovic","first_name":"Aleksandra"}],"publisher":"Springer Nature"},{"publication_status":"published","date_updated":"2025-09-30T10:44:48Z","scopus_import":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"doi":"10.1063/5.0241949","OA_place":"publisher","external_id":{"pmid":["39932241"],"arxiv":["2410.03316"],"isi":["001421300300001"]},"title":"Ionic association and Wien effect in 2D confined electrolytes","abstract":[{"lang":"eng","text":"Recent experimental advances in nanofluidics have allowed to explore ion transport across molecular-scale pores, in particular, for iontronic applications. Two-dimensional nanochannels—in which a single molecular layer of electrolyte is confined between solid walls—constitute a unique platform to investigate fluid and ion transport in extreme confinement, highlighting unconventional transport properties. In this work, we study ionic association in 2D nanochannels, and its consequences on non-linear ionic transport, using both molecular dynamics simulations and analytical theory. We show that under sufficient confinement, ions assemble into pairs or larger clusters in a process analogous to a Kosterlitz–Thouless transition, here modified by the dielectric confinement. We further show that the breaking of pairs results in an electric-field dependent conduction, a mechanism usually known as the second Wien effect. However the 2D nature of the system results in non-universal, temperature-dependent, scaling of the conductivity with electric field, leading to ionic coulomb blockade in some regimes. A 2D generalization of the Onsager theory fully accounts for the non-linear transport. These results suggest ways to exploit electrostatic interactions between ions to build new nanofluidic devices."}],"corr_author":"1","isi":1,"ddc":["540"],"month":"02","publication":"Journal of Chemical Physics","date_created":"2025-03-02T23:01:52Z","oa":1,"intvolume":"       162","_id":"19279","author":[{"first_name":"Damien","full_name":"Toquer, Damien","last_name":"Toquer"},{"last_name":"Bocquet","full_name":"Bocquet, Lydéric","first_name":"Lydéric"},{"full_name":"Robin, Paul","last_name":"Robin","first_name":"Paul","id":"48c58128-57b0-11ee-9095-dc28fd97fc1d","orcid":"0000-0002-5728-9189"}],"article_processing_charge":"Yes (in subscription journal)","publisher":"AIP Publishing","year":"2025","day":"14","date_published":"2025-02-14T00:00:00Z","department":[{"_id":"EdHa"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","arxiv":1,"acknowledgement":"The authors thank B. Coquinot and G. Monet for fruitful discussions. L.B. acknowledges support from ERC-Synergy Grant Agreement No. 101071937, n-AQUA. P.R. acknowledges support from the European Union’s Horizon 2020 research and innovation program under Marie Sklodowska-Curie Grant Agreement No. 101034413.","volume":162,"file_date_updated":"2025-03-04T10:29:36Z","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","file":[{"relation":"main_file","file_id":"19290","success":1,"creator":"dernst","checksum":"c9008c2c50c917673aa588f75acbcb40","content_type":"application/pdf","file_name":"2025_JourChemicalPhysics_Toquer.pdf","date_created":"2025-03-04T10:29:36Z","file_size":5807062,"date_updated":"2025-03-04T10:29:36Z","access_level":"open_access"}],"status":"public","ec_funded":1,"issue":"6","article_number":"064703","publication_identifier":{"eissn":["1089-7690"],"issn":["0021-9606"]},"has_accepted_license":"1","pmid":1,"type":"journal_article","quality_controlled":"1","project":[{"grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020"}],"tmp":{"short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"OA_type":"hybrid","article_type":"original","citation":{"ista":"Toquer D, Bocquet L, Robin P. 2025. Ionic association and Wien effect in 2D confined electrolytes. Journal of Chemical Physics. 162(6), 064703.","ama":"Toquer D, Bocquet L, Robin P. Ionic association and Wien effect in 2D confined electrolytes. <i>Journal of Chemical Physics</i>. 2025;162(6). doi:<a href=\"https://doi.org/10.1063/5.0241949\">10.1063/5.0241949</a>","short":"D. Toquer, L. Bocquet, P. Robin, Journal of Chemical Physics 162 (2025).","chicago":"Toquer, Damien, Lydéric Bocquet, and Paul Robin. “Ionic Association and Wien Effect in 2D Confined Electrolytes.” <i>Journal of Chemical Physics</i>. AIP Publishing, 2025. <a href=\"https://doi.org/10.1063/5.0241949\">https://doi.org/10.1063/5.0241949</a>.","apa":"Toquer, D., Bocquet, L., &#38; Robin, P. (2025). Ionic association and Wien effect in 2D confined electrolytes. <i>Journal of Chemical Physics</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/5.0241949\">https://doi.org/10.1063/5.0241949</a>","ieee":"D. Toquer, L. Bocquet, and P. Robin, “Ionic association and Wien effect in 2D confined electrolytes,” <i>Journal of Chemical Physics</i>, vol. 162, no. 6. AIP Publishing, 2025.","mla":"Toquer, Damien, et al. “Ionic Association and Wien Effect in 2D Confined Electrolytes.” <i>Journal of Chemical Physics</i>, vol. 162, no. 6, 064703, AIP Publishing, 2025, doi:<a href=\"https://doi.org/10.1063/5.0241949\">10.1063/5.0241949</a>."}},{"issue":"3","article_number":"033010","publication_identifier":{"eissn":["2835-8279"]},"has_accepted_license":"1","PlanS_conform":"1","type":"journal_article","project":[{"grant_number":"802960","call_identifier":"H2020","_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines"},{"grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020"},{"name":"EMBO Young Investigator Program - Andela Saric","_id":"349b6ff1-11ca-11ed-8bc3-f006047c2eeb"}],"quality_controlled":"1","citation":{"mla":"Sorichetti, Valerio, et al. “Charge Distribution of the Coating Brush Drives Interchromosome Attraction.” <i>PRX Life</i>, vol. 3, no. 3, 033010, American Physical Society, 2025, doi:<a href=\"https://doi.org/10.1103/41fd-r847\">10.1103/41fd-r847</a>.","ieee":"V. Sorichetti, P. Robin, I. Palaia, A. Hernandez-Armendariz, S. Cuylen-Haering, and A. Šarić, “Charge distribution of the coating brush drives interchromosome attraction,” <i>PRX Life</i>, vol. 3, no. 3. American Physical Society, 2025.","apa":"Sorichetti, V., Robin, P., Palaia, I., Hernandez-Armendariz, A., Cuylen-Haering, S., &#38; Šarić, A. (2025). Charge distribution of the coating brush drives interchromosome attraction. <i>PRX Life</i>. American Physical Society. <a href=\"https://doi.org/10.1103/41fd-r847\">https://doi.org/10.1103/41fd-r847</a>","chicago":"Sorichetti, Valerio, Paul Robin, Ivan Palaia, Alberto Hernandez-Armendariz, Sara Cuylen-Haering, and Anđela Šarić. “Charge Distribution of the Coating Brush Drives Interchromosome Attraction.” <i>PRX Life</i>. American Physical Society, 2025. <a href=\"https://doi.org/10.1103/41fd-r847\">https://doi.org/10.1103/41fd-r847</a>.","short":"V. Sorichetti, P. Robin, I. Palaia, A. Hernandez-Armendariz, S. Cuylen-Haering, A. Šarić, PRX Life 3 (2025).","ista":"Sorichetti V, Robin P, Palaia I, Hernandez-Armendariz A, Cuylen-Haering S, Šarić A. 2025. Charge distribution of the coating brush drives interchromosome attraction. PRX Life. 3(3), 033010.","ama":"Sorichetti V, Robin P, Palaia I, Hernandez-Armendariz A, Cuylen-Haering S, Šarić A. Charge distribution of the coating brush drives interchromosome attraction. <i>PRX Life</i>. 2025;3(3). doi:<a href=\"https://doi.org/10.1103/41fd-r847\">10.1103/41fd-r847</a>"},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"original","OA_type":"gold","publisher":"American Physical Society","_id":"21235","article_processing_charge":"Yes","author":[{"orcid":"0000-0002-9645-6576","first_name":"Valerio","id":"ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b","last_name":"Sorichetti","full_name":"Sorichetti, Valerio"},{"id":"48c58128-57b0-11ee-9095-dc28fd97fc1d","first_name":"Paul","orcid":"0000-0002-5728-9189","full_name":"Robin, Paul","last_name":"Robin"},{"last_name":"Palaia","full_name":"Palaia, Ivan","orcid":" 0000-0002-8843-9485 ","id":"9c805cd2-4b75-11ec-a374-db6dd0ed57fa","first_name":"Ivan"},{"first_name":"Alberto","full_name":"Hernandez-Armendariz, Alberto","last_name":"Hernandez-Armendariz"},{"full_name":"Cuylen-Haering, Sara","last_name":"Cuylen-Haering","first_name":"Sara"},{"first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela","last_name":"Šarić"}],"department":[{"_id":"AnSa"},{"_id":"EdHa"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2025","day":"11","date_published":"2025-08-11T00:00:00Z","acknowledgement":"This work was supported by the European Union’s Horizon 2020 research and innovation programme (A.Š. and V.S., ERC grant Agreement No. 802960 to A.Š., I.P. and P.R.,\r\nMarie Skłodowska-Curie Grant Agreement No. 101034413), the German Research Foundation (S.C-H. and A.H.-A., DFG Project No. 402723784 to S.C-H.), the Vallee Scholarship\r\n(A.Š. and V.S.), the EMBO Young Investigator Programme (A.Š.), and a Ph.D. fellowship from the Boehringer Ingelheim Fonds (A.H.-A.).","file":[{"access_level":"open_access","date_updated":"2026-02-17T11:12:30Z","date_created":"2026-02-17T11:12:30Z","file_size":3732843,"content_type":"application/pdf","file_name":"2025_PRXLife_Sorichetti.pdf","checksum":"1702b9bdbfd902a7c08aa4f1479b390d","success":1,"creator":"dernst","file_id":"21287","relation":"main_file"}],"status":"public","ec_funded":1,"volume":3,"file_date_updated":"2026-02-17T11:12:30Z","ddc":["570"],"month":"08","corr_author":"1","publication":"PRX Life","date_created":"2026-02-16T14:50:32Z","oa":1,"intvolume":"         3","publication_status":"published","date_updated":"2026-02-17T11:16:26Z","oa_version":"Published Version","language":[{"iso":"eng"}],"doi":"10.1103/41fd-r847","OA_place":"publisher","abstract":[{"lang":"eng","text":"The condensation of charged polymers is an important driver for the formation of biomolecular condensates. Recent experiments suggest that this mechanism also controls the clustering of eukaryotic chromosomes during the late stages of cell division. In this process, interchromosome attraction is driven by the condensation of cytoplasmic RNA and Ki-67, a charged intrinsically disordered protein that coats the chromosomes as a brush. Attraction between chromosomes has been shown to be specifically promoted by a localized charged patch on Ki-67, although the physical mechanism remains unclear. To elucidate this process, we combine coarse-grained simulations and analytical theory to study the RNA-mediated interaction between charged polymer brushes on the chromosome surfaces. We show that the charged patch on Ki-67 leads to interchromosome attraction via RNA bridging between the two brushes, whereby the RNA preferentially interacts with the charged patches, leading to stable, long-range forces. By contrast, if the brush is uniformly charged, bridging is basically absent due to complete adsorption of RNA onto the brush. Moreover, the RNA dynamics becomes caged in presence of the charged patch while remaining diffusive with uniform charge. Our work sheds light on the physical origin of chromosome clustering, while also suggesting a general mechanism for cells to tune work production by biomolecular condensates via different charge distributions."}],"title":"Charge distribution of the coating brush drives interchromosome attraction","DOAJ_listed":"1"},{"issue":"6","article_number":"064503","publication_identifier":{"eissn":["1089-7690"],"issn":["0021-9606"]},"has_accepted_license":"1","pmid":1,"type":"journal_article","project":[{"grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020"}],"quality_controlled":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"original","citation":{"ista":"Robin P. 2024. Correlation-induced viscous dissipation in concentrated electrolytes. Journal of Chemical Physics. 160(6), 064503.","ama":"Robin P. Correlation-induced viscous dissipation in concentrated electrolytes. <i>Journal of Chemical Physics</i>. 2024;160(6). doi:<a href=\"https://doi.org/10.1063/5.0188215\">10.1063/5.0188215</a>","apa":"Robin, P. (2024). Correlation-induced viscous dissipation in concentrated electrolytes. <i>Journal of Chemical Physics</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/5.0188215\">https://doi.org/10.1063/5.0188215</a>","ieee":"P. Robin, “Correlation-induced viscous dissipation in concentrated electrolytes,” <i>Journal of Chemical Physics</i>, vol. 160, no. 6. AIP Publishing, 2024.","chicago":"Robin, Paul. “Correlation-Induced Viscous Dissipation in Concentrated Electrolytes.” <i>Journal of Chemical Physics</i>. AIP Publishing, 2024. <a href=\"https://doi.org/10.1063/5.0188215\">https://doi.org/10.1063/5.0188215</a>.","short":"P. Robin, Journal of Chemical Physics 160 (2024).","mla":"Robin, Paul. “Correlation-Induced Viscous Dissipation in Concentrated Electrolytes.” <i>Journal of Chemical Physics</i>, vol. 160, no. 6, 064503, AIP Publishing, 2024, doi:<a href=\"https://doi.org/10.1063/5.0188215\">10.1063/5.0188215</a>."},"_id":"15024","article_processing_charge":"Yes (in subscription journal)","author":[{"orcid":"0000-0002-5728-9189","id":"48c58128-57b0-11ee-9095-dc28fd97fc1d","first_name":"Paul","last_name":"Robin","full_name":"Robin, Paul"}],"publisher":"AIP Publishing","day":"14","year":"2024","date_published":"2024-02-14T00:00:00Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"EdHa"}],"acknowledgement":"The author thanks Lydéric Bocquet, Baptiste Coquinot, and Mathieu Lizée for fruitful discussions. This project received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 101034413.","arxiv":1,"file_date_updated":"2024-02-27T08:12:52Z","volume":160,"file":[{"access_level":"open_access","date_updated":"2024-02-27T08:12:52Z","date_created":"2024-02-27T08:12:52Z","file_size":5452738,"content_type":"application/pdf","checksum":"0a5e0ae70849bce674466fc054390ec0","file_name":"2024_JourChemicalPhysics_Robin.pdf","creator":"dernst","success":1,"file_id":"15034","relation":"main_file"}],"ec_funded":1,"status":"public","corr_author":"1","ddc":["540"],"isi":1,"month":"02","publication":"Journal of Chemical Physics","date_created":"2024-02-25T23:00:55Z","oa":1,"intvolume":"       160","date_updated":"2025-09-04T12:07:33Z","publication_status":"published","scopus_import":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"doi":"10.1063/5.0188215","external_id":{"pmid":["38349632"],"isi":["001161104900003"],"arxiv":["2311.11784"]},"abstract":[{"text":"Electrostatic correlations between ions dissolved in water are known to impact their transport properties in numerous ways, from conductivity to ion selectivity. The effects of these correlations on the solvent itself remain, however, much less clear. In particular, the addition of salt has been consistently reported to affect the solution’s viscosity, but most modeling attempts fail to reproduce experimental data even at moderate salt concentrations. Here, we use an approach based on stochastic density functional theory, which accurately captures charge fluctuations and correlations. We derive a simple analytical expression for the viscosity correction in concentrated electrolytes, by directly linking it to the liquid’s structure factor. Our prediction compares quantitatively to experimental data at all temperatures and all salt concentrations up to the saturation limit. This universal link between the microscopic structure and viscosity allows us to shed light on the nanoscale dynamics of water and ions under highly concentrated and correlated conditions.","lang":"eng"}],"title":"Correlation-induced viscous dissipation in concentrated electrolytes"}]