@article{17884,
  abstract     = {Human T cell leukemia virus type 1 (HTLV-1) immature particles differ in morphology from other retroviruses, suggesting a distinct way of assembly. Here we report the results of cryo-electron tomography studies of HTLV-1 virus-like particles assembled in vitro, as well as derived from cells. This work shows that HTLV-1 uses a distinct mechanism of Gag–Gag interactions to form the immature viral lattice. Analysis of high-resolution structural information from immature capsid (CA) tubular arrays reveals that the primary stabilizing component in HTLV-1 is the N-terminal domain of CA. Mutagenesis analysis supports this observation. This distinguishes HTLV-1 from other retroviruses, in which the stabilization is provided primarily by the C-terminal domain of CA. These results provide structural details of the quaternary arrangement of Gag for an immature deltaretrovirus and this helps explain why HTLV-1 particles are morphologically distinct.},
  author       = {Obr, Martin and Percipalle, Mathias and Chernikova, Darya and Yang, Huixin and Thader, Andreas and Pinke, Gergely and Porley, Dario J and Mansky, Louis M. and Dick, Robert A. and Schur, Florian KM},
  issn         = {1545-9985},
  journal      = {Nature Structural & Molecular Biology},
  pages        = {268--276},
  publisher    = {Springer Nature},
  title        = {{Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice}},
  doi          = {10.1038/s41594-024-01390-8},
  volume       = {32},
  year         = {2025},
}

@article{14784,
  abstract     = {The next steps of deep space exploration are manned missions to Moon and Mars. For safe space missions for crew members, it is important to understand the impact of space flight on the immune system. We studied the effects of 21 days dry immersion (DI) exposure on the transcriptomes of T cells isolated from blood samples of eight healthy volunteers. Samples were collected 7 days before DI, at day 7, 14, and 21 during DI, and 7 days after DI. RNA sequencing of CD3+T cells revealed transcriptional alterations across all time points, with most changes occurring 14 days after DI exposure. At day 21, T cells showed evidence of adaptation with a transcriptional profile resembling that of 7 days before DI. At 7 days after DI, T cells again changed their transcriptional profile. These data suggest that T cells adapt by rewiring their transcriptomes in response to simulated weightlessness and that remodeling cues persist when reexposed to normal gravity.},
  author       = {Gallardo-Dodd, Carlos J. and Oertlin, Christian and Record, Julien and Galvani, Rômulo G. and Sommerauer, Christian and Kuznetsov, Nikolai V. and Doukoumopoulos, Evangelos and Ali, Liaqat and Oliveira, Mariana M. S. and Seitz, Christina and Percipalle, Mathias and Nikić, Tijana and Sadova, Anastasia A. and Shulgina, Sofia M. and Shmarov, Vjacheslav A. and Kutko, Olga V. and Vlasova, Daria D. and Orlova, Kseniya D. and Rykova, Marina P. and Andersson, John and Percipalle, Piergiorgio and Kutter, Claudia and Ponomarev, Sergey A. and Westerberg, Lisa S.},
  issn         = {2375-2548},
  journal      = {Science Advances},
  keywords     = {Multidisciplinary},
  number       = {34},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells}},
  doi          = {10.1126/sciadv.adg1610},
  volume       = {9},
  year         = {2023},
}