[{"title":"Research Data for 'Causes and consequences of sex-chromosome turnovers in Diptera'","license":"https://creativecommons.org/licenses/by/4.0/","oa":1,"file_date_updated":"2026-01-08T01:35:08Z","keyword":["Schizophora","sex chromosomes","sex-chromosome turnover","Diptera","genomic features","out-of-X movement."],"article_processing_charge":"No","abstract":[{"lang":"eng","text":"Sex-chromosome systems are highly variable across animals, but how they transition from one to another is not well understood. Diptera have undergone multiple sex-chromosome turnovers and expansions while maintaining their general chromosomal content, which makes them an ideal clade to study such transitions. We analysed more than 100 dipteran whole-genome assemblies and identified 4 new lineages that underwent sex-chromosome turnover (in addition to the 5 previously reported). We find the majority of turnovers happened in the group Schizophora, which tend to have fewer genes on the F element (the chromosome homologous to the ancestral insect X chromosome) than lower dipterans, a factor previously hypothesized to facilitate turnover. Most derived X chromosomes have higher GC content than autosomes, consistent with a high prevalence of male-achiasmy in Diptera. In addition, an excess of gene movement out of the X is detected for most of these new X chromosomes, and many of these moved genes have high testis expression in Drosophila, suggesting that out-of-X gene movement contributes to the long-term demasculinization of X chromosomes."}],"day":"8","date_created":"2025-12-17T10:10:57Z","department":[{"_id":"BeVi"}],"month":"01","date_published":"2026-01-08T00:00:00Z","date_updated":"2026-06-10T09:21:49Z","publisher":"Institute of Science and Technology Austria","status":"public","author":[{"id":"02814589-eb8f-11eb-b029-a70074f3f18f","full_name":"Layana Franco, Lorena Alexandra","first_name":"Lorena Alexandra","last_name":"Layana Franco","orcid":"0000-0002-1253-6297"},{"id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","first_name":"Melissa A","full_name":"Toups, Melissa A","last_name":"Toups","orcid":"0000-0002-9752-7380"},{"last_name":"Vicoso","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz"}],"year":"2026","doi":"10.15479/AT-ISTA-20833","_id":"20833","corr_author":"1","has_accepted_license":"1","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","type":"research_data","file":[{"success":1,"file_size":1201,"checksum":"0b79be6229f2ad9ac117ef00fc4f5c0e","access_level":"open_access","content_type":"text/plain","creator":"llayanaf","date_updated":"2025-12-17T10:09:25Z","relation":"main_file","date_created":"2025-12-17T10:09:25Z","file_name":"README.txt","file_id":"20834"},{"date_created":"2025-12-17T10:10:11Z","file_name":"Supplementary_Datasets.zip","relation":"main_file","file_id":"20835","access_level":"open_access","file_size":19052849,"content_type":"application/zip","checksum":"daf1c03149dd170b14e5c8e109ee3c77","creator":"llayanaf","success":1,"date_updated":"2025-12-17T10:10:11Z"},{"file_name":"Perl_scripts.zip","date_created":"2025-12-17T10:12:05Z","relation":"main_file","file_id":"20837","creator":"llayanaf","content_type":"application/zip","checksum":"251e7aab01917c2ad2fbccf465492ea1","access_level":"open_access","file_size":4575,"success":1,"date_updated":"2025-12-17T10:12:05Z"},{"content_type":"application/zip","checksum":"3cabf143b8cd286eae48c598da2b03bd","access_level":"open_access","file_size":572362,"creator":"llayanaf","success":1,"date_updated":"2026-01-08T01:35:08Z","date_created":"2026-01-08T01:35:08Z","file_name":"Supplementary_Tables.zip","relation":"main_file","file_id":"20959"}],"citation":{"ista":"Layana Franco LA, Toups MA, Vicoso B. 2026. Research Data for ‘Causes and consequences of sex-chromosome turnovers in Diptera’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-20833\">10.15479/AT-ISTA-20833</a>.","short":"L.A. Layana Franco, M.A. Toups, B. Vicoso, (2026).","chicago":"Layana Franco, Lorena Alexandra, Melissa A Toups, and Beatriz Vicoso. “Research Data for ‘Causes and Consequences of Sex-Chromosome Turnovers in Diptera.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-20833\">https://doi.org/10.15479/AT-ISTA-20833</a>.","ieee":"L. A. Layana Franco, M. A. Toups, and B. Vicoso, “Research Data for ‘Causes and consequences of sex-chromosome turnovers in Diptera.’” Institute of Science and Technology Austria, 2026.","mla":"Layana Franco, Lorena Alexandra, et al. <i>Research Data for “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20833\">10.15479/AT-ISTA-20833</a>.","ama":"Layana Franco LA, Toups MA, Vicoso B. Research Data for “Causes and consequences of sex-chromosome turnovers in Diptera.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20833\">10.15479/AT-ISTA-20833</a>","apa":"Layana Franco, L. A., Toups, M. A., &#38; Vicoso, B. (2026). Research Data for “Causes and consequences of sex-chromosome turnovers in Diptera.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20833\">https://doi.org/10.15479/AT-ISTA-20833</a>"},"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"}},{"publisher":"Institute of Science and Technology Austria","date_published":"2026-01-02T00:00:00Z","month":"01","date_updated":"2026-02-12T12:58:00Z","department":[{"_id":"BeVi"}],"article_processing_charge":"No","abstract":[{"text":"Sex-chromosome systems are highly variable across animals, but how they transition from one to another is not well understood. Diptera have undergone multiple sex-chromosome turnovers and expansions while maintaining their general chromosomal content, which makes them an ideal clade to study such transitions. We analyzed more than 100 dipteran whole-genome assemblies and identified 4 new lineages that underwent sex-chromosome turnover (in addition to the 5 previously reported). We find that the majority of turnovers happened in the group Schizophora, which tend to have fewer genes on Muller element F (the chromosome homologous to the ancestral insect X chromosome) than lower dipterans, a factor previously hypothesized to facilitate turnover. Most derived X chromosomes have higher GC content than autosomes, consistent with a high prevalence of male achiasmy in Diptera. In addition, an excess of gene movement out of the X is detected for most of these new X chromosomes, and many of these moved genes have high testis expression in Drosophila, suggesting that out-of-X gene movement contributes to the long-term demasculinization of X chromosomes.","lang":"eng"}],"day":"2","date_created":"2026-01-30T11:04:14Z","file_date_updated":"2026-01-30T11:00:56Z","keyword":["Schizophora","sex chromosomes","sex-chromosome turnover","Diptera","genomic features","out-of-X movement."],"title":"Research Data for \"Causes and consequences of sex-chromosome turnovers in Diptera\"","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"citation":{"ista":"Layana Franco LA, Toups MA, Vicoso B. 2026. Research Data for ‘Causes and consequences of sex-chromosome turnovers in Diptera’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21116\">10.15479/AT-ISTA-21116</a>.","short":"L.A. Layana Franco, M.A. Toups, B. Vicoso, (2026).","chicago":"Layana Franco, Lorena Alexandra, Melissa A Toups, and Beatriz Vicoso. “Research Data for ‘Causes and Consequences of Sex-Chromosome Turnovers in Diptera.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21116\">https://doi.org/10.15479/AT-ISTA-21116</a>.","mla":"Layana Franco, Lorena Alexandra, et al. <i>Research Data for “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21116\">10.15479/AT-ISTA-21116</a>.","ieee":"L. A. Layana Franco, M. A. Toups, and B. Vicoso, “Research Data for ‘Causes and consequences of sex-chromosome turnovers in Diptera.’” Institute of Science and Technology Austria, 2026.","ama":"Layana Franco LA, Toups MA, Vicoso B. Research Data for “Causes and consequences of sex-chromosome turnovers in Diptera.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21116\">10.15479/AT-ISTA-21116</a>","apa":"Layana Franco, L. A., Toups, M. A., &#38; Vicoso, B. (2026). Research Data for “Causes and consequences of sex-chromosome turnovers in Diptera.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21116\">https://doi.org/10.15479/AT-ISTA-21116</a>"},"file":[{"file_name":"README.txt","date_created":"2026-01-30T11:00:24Z","relation":"main_file","file_id":"21117","creator":"llayanaf","file_size":1201,"content_type":"text/plain","access_level":"open_access","checksum":"0b79be6229f2ad9ac117ef00fc4f5c0e","success":1,"date_updated":"2026-01-30T11:00:24Z"},{"relation":"main_file","date_created":"2026-01-30T11:00:36Z","file_name":"Supplementary_Tables.zip","file_id":"21118","success":1,"access_level":"open_access","content_type":"application/zip","checksum":"a3cda72e4177fa1e5d3f0f6a88f8a79b","file_size":572403,"creator":"llayanaf","date_updated":"2026-01-30T11:00:36Z"},{"file_id":"21119","file_name":"Supplementary_Datasets.zip","date_created":"2026-01-30T11:00:48Z","relation":"main_file","date_updated":"2026-01-30T11:00:48Z","creator":"llayanaf","file_size":19054553,"content_type":"application/zip","access_level":"open_access","checksum":"efb5b64698d6ca9e7b675204f6fc1c29","success":1},{"success":1,"creator":"llayanaf","access_level":"open_access","checksum":"254e050f648e9783ba8fe11adb3b49db","file_size":4575,"content_type":"application/zip","date_updated":"2026-01-30T11:00:56Z","relation":"main_file","file_name":"Perl_scripts.zip","date_created":"2026-01-30T11:00:56Z","file_id":"21120"}],"oa_version":"Published Version","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","type":"research_data","corr_author":"1","has_accepted_license":"1","doi":"10.15479/AT-ISTA-21116","_id":"21116","author":[{"id":"02814589-eb8f-11eb-b029-a70074f3f18f","first_name":"Lorena Alexandra","full_name":"Layana Franco, Lorena Alexandra","last_name":"Layana Franco","orcid":"0000-0002-1253-6297"},{"id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","first_name":"Melissa A","full_name":"Toups, Melissa A","last_name":"Toups","orcid":"0000-0002-9752-7380"},{"last_name":"Vicoso","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz"}],"status":"public","year":"2026"},{"article_processing_charge":"Yes (via OA deal)","article_number":"20252471","department":[{"_id":"BeVi"}],"oa":1,"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"}],"publisher":"Royal Society of London","article_type":"original","date_published":"2026-01-28T00:00:00Z","month":"01","date_updated":"2026-02-16T09:27:33Z","publication_status":"published","PlanS_conform":"1","has_accepted_license":"1","corr_author":"1","issue":"2063","year":"2026","status":"public","file":[{"success":1,"access_level":"open_access","content_type":"application/pdf","file_size":2230841,"checksum":"d76afebca0a6f112df0146ae2d929f36","creator":"dernst","date_updated":"2026-02-16T09:26:02Z","relation":"main_file","date_created":"2026-02-16T09:26:02Z","file_name":"2026_RoyalSocPubProceedingsB_Barata.pdf","file_id":"21226"}],"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"hybrid","OA_place":"publisher","publication_identifier":{"eissn":["1471-2954"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"28","abstract":[{"text":"In many species, sex-biased expression is widespread and thought to contribute to sexual dimorphism. While bulk RNA-sequencing has been instrumental in identifying strongly sex-biased genes, it lacks resolution to assess variation across cell-types and tissue compartments. Using single-nucleus expression data from the Fly Cell Atlas, we investigate sex differences in adult Drosophila melanogaster. We find that differences in cell-type composition between the sexes are not a major source of sex-bias, as for the vast majority of genes, the degree of sex-bias is similar regardless of whether sex differences in cell-type composition are controlled for or not. Our analysis confirms a deficit of X-linked male-biased genes in the body’s somatic tissues that is widespread across cell-types. We also find the excess of X-linked female-biased genes to be associated with nervous system cells in the head but with epithelial cells in the body’s somatic tissues, showing that single-nucleus data crucially resolves sex-bias at the cell-type level. We investigate dosage compensation (DC) across 15 tissues and 17 cell-types. We observe that it varies throughout the body. Surprisingly, we observe a lack of DC in a cluster of main cells within the male accessory glands. This result highlights the importance of understanding context-dependent DC.","lang":"eng"}],"date_created":"2026-02-08T23:02:49Z","title":"Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster","language":[{"iso":"eng"}],"file_date_updated":"2026-02-16T09:26:02Z","volume":293,"pmid":1,"scopus_import":"1","doi":"10.1098/rspb.2025.2471","_id":"21161","project":[{"_id":"90ef7108-16d5-11f0-9cad-e6e116913473","name":"Does genetic drift set a limit on the adaptive evolution of sex-biased expression?","grant_number":"ESP 6331524"}],"quality_controlled":"1","author":[{"last_name":"De Castro Barbosa Rodrigues Barata","orcid":"0000-0003-1945-2245","id":"20565186-803f-11ed-ab7e-96a4ff7694ef","full_name":"De Castro Barbosa Rodrigues Barata, Carolina","first_name":"Carolina"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz","last_name":"Vicoso","orcid":"0000-0002-4579-8306"}],"acknowledgement":"This work was partly funded by an Austrian Science Foundation FWF ESPRIT fellowship (10.55776/ESP6331524) to C.B. We would like to thank the Vicoso group for their invaluable input and discussions throughout this work. We thank Filip Ruzicka for his insightful comments on the manuscript. All computational resources were provided by the Scientific Computing Unit at ISTA. This research was also supported through resources provided by the Imaging & Optics Facility (IOF) at ISTA.","citation":{"ieee":"C. de Castro Barbosa Rodrigues Barata and B. Vicoso, “Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster,” <i>Proceedings of the Royal Society B Biological Sciences</i>, vol. 293, no. 2063. Royal Society of London, 2026.","mla":"de Castro Barbosa Rodrigues Barata, Carolina, and Beatriz Vicoso. “Single-Nucleus Resolution of Sex-Biased Expression and Dosage Compensation in Drosophila Melanogaster.” <i>Proceedings of the Royal Society B Biological Sciences</i>, vol. 293, no. 2063, 20252471, Royal Society of London, 2026, doi:<a href=\"https://doi.org/10.1098/rspb.2025.2471\">10.1098/rspb.2025.2471</a>.","ama":"de Castro Barbosa Rodrigues Barata C, Vicoso B. Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster. <i>Proceedings of the Royal Society B Biological Sciences</i>. 2026;293(2063). doi:<a href=\"https://doi.org/10.1098/rspb.2025.2471\">10.1098/rspb.2025.2471</a>","apa":"de Castro Barbosa Rodrigues Barata, C., &#38; Vicoso, B. (2026). Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster. <i>Proceedings of the Royal Society B Biological Sciences</i>. Royal Society of London. <a href=\"https://doi.org/10.1098/rspb.2025.2471\">https://doi.org/10.1098/rspb.2025.2471</a>","ista":"de Castro Barbosa Rodrigues Barata C, Vicoso B. 2026. Single-nucleus resolution of sex-biased expression and dosage compensation in Drosophila melanogaster. Proceedings of the Royal Society B Biological Sciences. 293(2063), 20252471.","short":"C. de Castro Barbosa Rodrigues Barata, B. Vicoso, Proceedings of the Royal Society B Biological Sciences 293 (2026).","chicago":"Castro Barbosa Rodrigues Barata, Carolina de, and Beatriz Vicoso. “Single-Nucleus Resolution of Sex-Biased Expression and Dosage Compensation in Drosophila Melanogaster.” <i>Proceedings of the Royal Society B Biological Sciences</i>. Royal Society of London, 2026. <a href=\"https://doi.org/10.1098/rspb.2025.2471\">https://doi.org/10.1098/rspb.2025.2471</a>."},"external_id":{"pmid":["41592777"]},"ddc":["570"],"intvolume":"       293","type":"journal_article","publication":"Proceedings of the Royal Society B Biological Sciences"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1537-1719"]},"OA_place":"publisher","OA_type":"gold","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","file":[{"relation":"main_file","file_name":"2026_MolecularBioEvolution_Presgraves.pdf","date_created":"2026-03-09T10:32:02Z","file_id":"21414","success":1,"creator":"dernst","content_type":"application/pdf","file_size":4533829,"checksum":"406e7cca0f2536d3bb877032fc837f9b","access_level":"open_access","date_updated":"2026-03-09T10:32:02Z"}],"status":"public","year":"2026","issue":"2","has_accepted_license":"1","PlanS_conform":"1","date_updated":"2026-03-09T10:33:04Z","publication_status":"published","date_published":"2026-02-02T00:00:00Z","month":"02","article_type":"original","publisher":"Oxford University Press","oa":1,"department":[{"_id":"BeVi"}],"article_number":"msag020","article_processing_charge":"Yes","publication":"Molecular Biology and Evolution","type":"journal_article","intvolume":"        43","external_id":{"pmid":["41589062"]},"ddc":["570"],"citation":{"chicago":"Presgraves, Daven C., R. Kelly Dawe, Kelly A. Dyer, Lila Fishman, Soumitra A. Bhide, Sasha L. Bradshaw, Meghan J. Brady, et al. “The Evolutionary Genomics of Meiotic Drive.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2026. <a href=\"https://doi.org/10.1093/molbev/msag020\">https://doi.org/10.1093/molbev/msag020</a>.","short":"D.C. Presgraves, R.K. Dawe, K.A. Dyer, L. Fishman, S.A. Bhide, S.L. Bradshaw, M.J. Brady, A. Burga, C. Courret, B.L. Fagen, A.B.S. Machado Ferretti, R.K. Kelemen, J. Kitano, Y. Liu, E. Martí, T. Erlenbach, J.A. Reinhardt, L. Ross, J.N. Runge, C.M. Swanepoel, B. Vicoso, A.A. Vogan, A.K. Lindholm, A.M. Larracuente, R.L. Unckless, Molecular Biology and Evolution 43 (2026).","ista":"Presgraves DC, Dawe RK, Dyer KA, Fishman L, Bhide SA, Bradshaw SL, Brady MJ, Burga A, Courret C, Fagen BL, Machado Ferretti ABS, Kelemen RK, Kitano J, Liu Y, Martí E, Erlenbach T, Reinhardt JA, Ross L, Runge JN, Swanepoel CM, Vicoso B, Vogan AA, Lindholm AK, Larracuente AM, Unckless RL. 2026. The evolutionary genomics of meiotic drive. Molecular Biology and Evolution. 43(2), msag020.","apa":"Presgraves, D. C., Dawe, R. K., Dyer, K. A., Fishman, L., Bhide, S. A., Bradshaw, S. L., … Unckless, R. L. (2026). The evolutionary genomics of meiotic drive. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/molbev/msag020\">https://doi.org/10.1093/molbev/msag020</a>","ama":"Presgraves DC, Dawe RK, Dyer KA, et al. The evolutionary genomics of meiotic drive. <i>Molecular Biology and Evolution</i>. 2026;43(2). doi:<a href=\"https://doi.org/10.1093/molbev/msag020\">10.1093/molbev/msag020</a>","mla":"Presgraves, Daven C., et al. “The Evolutionary Genomics of Meiotic Drive.” <i>Molecular Biology and Evolution</i>, vol. 43, no. 2, msag020, Oxford University Press, 2026, doi:<a href=\"https://doi.org/10.1093/molbev/msag020\">10.1093/molbev/msag020</a>.","ieee":"D. C. Presgraves <i>et al.</i>, “The evolutionary genomics of meiotic drive,” <i>Molecular Biology and Evolution</i>, vol. 43, no. 2. Oxford University Press, 2026."},"acknowledgement":"This review is a product of the SMBE satellite workshop and the SNSF Scientific Exchange on the Genomic Consequences of Meiotic Drive. We thank the Society for Molecular Biology and Evolution (satellite grant to A.M.L., A.K.L., R.L.U., D.C.P.), the Swiss National Science Foundation (Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung IZSEZ0_217501 to A.K.L.), and the National Science Foundation Division of Molecular and Cellular Biosciences (NSF MCB Conference grant 2312190 to R.L.U.) for their generous support of the workshop.\r\n\r\nWe also thank the following for their support of individual authors: National Science Foundation Division of Molecular and Cellular Biosciences (NSF MCB CAREER 2047052 to R.L.U.), Division of Environmental Biology (NSF DEB-2344468 to L.F., NSF DEB-1737824 to K.A.D.), National Institute of General Medical Sciences (NIH R35GM119515 to A.M.L., NIH R01GM148442 to D.C.P.), European Research Council (PGErepro to L.R.), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP 2020/06188-5 to A.B.S.M.F.), Royal Society (DHF\\R1\\180120 to L.R.), Wissenschaftskolleg zu Berlin (support for D.C.P.), and Vetenskapsrådet (Swedish Research Council VR grant number 2021-0429 to A.A.V.).","author":[{"full_name":"Presgraves, Daven C.","first_name":"Daven C.","last_name":"Presgraves"},{"last_name":"Dawe","first_name":"R. Kelly","full_name":"Dawe, R. Kelly"},{"full_name":"Dyer, Kelly A.","first_name":"Kelly A.","last_name":"Dyer"},{"last_name":"Fishman","first_name":"Lila","full_name":"Fishman, Lila"},{"full_name":"Bhide, Soumitra A.","first_name":"Soumitra A.","last_name":"Bhide"},{"last_name":"Bradshaw","first_name":"Sasha L.","full_name":"Bradshaw, Sasha L."},{"first_name":"Meghan J.","full_name":"Brady, Meghan J.","last_name":"Brady"},{"first_name":"Alejandro","full_name":"Burga, Alejandro","last_name":"Burga"},{"full_name":"Courret, Cécile","first_name":"Cécile","last_name":"Courret"},{"last_name":"Fagen","full_name":"Fagen, Brandon L.","first_name":"Brandon L."},{"last_name":"Machado Ferretti","first_name":"Ana Beatriz Stein","full_name":"Machado Ferretti, Ana Beatriz Stein"},{"id":"48D3F8DE-F248-11E8-B48F-1D18A9856A87","first_name":"Réka K","full_name":"Kelemen, Réka K","last_name":"Kelemen","orcid":"0000-0002-8489-9281"},{"last_name":"Kitano","full_name":"Kitano, Jun","first_name":"Jun"},{"last_name":"Liu","first_name":"Yiran","full_name":"Liu, Yiran"},{"full_name":"Martí, Emiliano","first_name":"Emiliano","last_name":"Martí"},{"last_name":"Erlenbach","first_name":"Theresa","full_name":"Erlenbach, Theresa"},{"last_name":"Reinhardt","first_name":"Josephine A.","full_name":"Reinhardt, Josephine A."},{"last_name":"Ross","first_name":"Laura","full_name":"Ross, Laura"},{"last_name":"Runge","first_name":"Jan Niklas","full_name":"Runge, Jan Niklas"},{"full_name":"Swanepoel, Callie M.","first_name":"Callie M.","last_name":"Swanepoel"},{"first_name":"Beatriz","full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","last_name":"Vicoso"},{"first_name":"Aaron A.","full_name":"Vogan, Aaron A.","last_name":"Vogan"},{"last_name":"Lindholm","full_name":"Lindholm, Anna K.","first_name":"Anna K."},{"last_name":"Larracuente","first_name":"Amanda M.","full_name":"Larracuente, Amanda M."},{"last_name":"Unckless","full_name":"Unckless, Robert L.","first_name":"Robert L."}],"quality_controlled":"1","_id":"21409","doi":"10.1093/molbev/msag020","scopus_import":"1","pmid":1,"volume":43,"file_date_updated":"2026-03-09T10:32:02Z","language":[{"iso":"eng"}],"title":"The evolutionary genomics of meiotic drive","DOAJ_listed":"1","date_created":"2026-03-08T23:01:45Z","day":"02","abstract":[{"lang":"eng","text":"Meiotic drivers are selfish genetic elements that gain transmission advantages by distorting equal, Mendelian segregation. For decades, biologists have considered meiotic drivers as interesting, albeit esoteric, case studies. It is now clear, however, that meiotic drive is more common and phylogenetically widespread than previously supposed. Indeed, intensive study of a few well-known cases has begun to reveal the evolutionary genomic consequences of meiotic drive. We argue here that many features of genome evolution, content, and organization that are seemingly inexplicable by organismal adaptation or nearly neutral processes are instead best accounted for by recurrent histories of meiotic drive. We review how meiotic drive can affect the evolution of sequences, gene copy numbers, genes with functions in meiosis and gametogenesis, signatures of “selection,” chromosome rearrangements, and karyotype evolution. We also explore the interactions of meiotic drive elements with other classes of selfish genetic elements, including satellite DNAs, transposable elements, and with the endogenous host genes involved in drive suppression. Finally, we argue that some aspects of drive-mediated genome evolution are now sufficiently well established that we might reverse the direction of discovery—rather than ask how drive affects genome evolution, we can use genome data to discover new putative drive elements."}]},{"day":"12","abstract":[{"text":"Sex-chromosome systems are highly variable across animals, but how they transition from one to another is not well understood. Diptera have undergone multiple sex-chromosome turnovers and expansions while maintaining their general chromosomal content, which makes them an ideal clade to study such transitions. We analyzed more than 100 dipteran whole-genome assemblies and identified 4 new lineages that underwent sex-chromosome turnover (in addition to the 5 previously reported). We find that the majority of turnovers happened in the group Schizophora, which tend to have fewer genes on Muller element F (the chromosome homologous to the ancestral insect X chromosome) than lower dipterans, a factor previously hypothesized to facilitate turnover. Most derived X chromosomes have higher GC content than autosomes, consistent with a high prevalence of male achiasmy in Diptera. In addition, an excess of gene movement out of the X is detected for most of these new X chromosomes, and many of these moved genes have high testis expression in Drosophila, suggesting that out-of-X gene movement contributes to the long-term demasculinization of X chromosomes.","lang":"eng"}],"date_created":"2026-03-23T15:05:42Z","DOAJ_listed":"1","title":"Causes and consequences of sex-chromosome turnovers in Diptera","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://doi.org/10.1093/evlett/qrag003","open_access":"1"}],"citation":{"short":"L.A. Layana Franco, M.A. Toups, B. Vicoso, Evolution Letters (2026).","chicago":"Layana Franco, Lorena Alexandra, Melissa A Toups, and Beatriz Vicoso. “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.” <i>Evolution Letters</i>. Oxford University Press, 2026. <a href=\"https://doi.org/10.1093/evlett/qrag003\">https://doi.org/10.1093/evlett/qrag003</a>.","ista":"Layana Franco LA, Toups MA, Vicoso B. 2026. Causes and consequences of sex-chromosome turnovers in Diptera. Evolution Letters., qrag003.","ama":"Layana Franco LA, Toups MA, Vicoso B. Causes and consequences of sex-chromosome turnovers in Diptera. <i>Evolution Letters</i>. 2026. doi:<a href=\"https://doi.org/10.1093/evlett/qrag003\">10.1093/evlett/qrag003</a>","apa":"Layana Franco, L. A., Toups, M. A., &#38; Vicoso, B. (2026). Causes and consequences of sex-chromosome turnovers in Diptera. <i>Evolution Letters</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/evlett/qrag003\">https://doi.org/10.1093/evlett/qrag003</a>","mla":"Layana Franco, Lorena Alexandra, et al. “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.” <i>Evolution Letters</i>, qrag003, Oxford University Press, 2026, doi:<a href=\"https://doi.org/10.1093/evlett/qrag003\">10.1093/evlett/qrag003</a>.","ieee":"L. A. Layana Franco, M. A. Toups, and B. Vicoso, “Causes and consequences of sex-chromosome turnovers in Diptera,” <i>Evolution Letters</i>. Oxford University Press, 2026."},"acknowledgement":"This work was supported by a grant from the Austrian Science Fund (FWF, grant number PAT 8748323) to B.V. We thank the Vicoso group for their feedback on an early version of the manuscript. We are grateful to Kamil Jaron and Julia Gries for helpful discussions and for sharing their unpublished work. Computational resources and support were provided by the Scientific Computing Unit at ISTA.","ddc":["570"],"publication":"Evolution Letters","type":"journal_article","doi":"10.1093/evlett/qrag003","_id":"21486","project":[{"_id":"8ed82125-16d5-11f0-9cad-fbcae312235b","grant_number":"PAT 8748323","name":"Sex chromosomes in evolution and development"}],"quality_controlled":"1","author":[{"full_name":"Layana Franco, Lorena Alexandra","first_name":"Lorena Alexandra","id":"02814589-eb8f-11eb-b029-a70074f3f18f","orcid":"0000-0002-1253-6297","last_name":"Layana Franco"},{"last_name":"Toups","orcid":"0000-0002-9752-7380","id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","full_name":"Toups, Melissa A","first_name":"Melissa A"},{"last_name":"Vicoso","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz"}],"publisher":"Oxford University Press","date_published":"2026-03-12T00:00:00Z","month":"03","article_type":"original","publication_status":"epub_ahead","date_updated":"2026-03-24T07:14:08Z","article_processing_charge":"Yes","department":[{"_id":"BeVi"},{"_id":"GradSch"}],"article_number":"qrag003","oa":1,"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"gold","OA_place":"publisher","publication_identifier":{"eissn":["2056-3744"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","corr_author":"1","has_accepted_license":"1","year":"2026","status":"public"},{"pmid":1,"isi":1,"scopus_import":"1","abstract":[{"lang":"eng","text":"Sex-linked and autosomal loci experience different selective pressures and evolutionary dynamics. X (or Z) chromosomes are often hemizygous in males (or females), as Y (or W) chromosomes often degenerate. Such hemizygous regions can be under greater efficacy of selection, as recessive mutations are immediately exposed to selection in the heterogametic sex leading to faster adaptation and faster divergence on the X chromosome (the so-called Faster-X or Faster-Z effect). However, in young nonrecombining regions, Y/W chromosomes often have many functional genes, and many X/Z-linked loci are therefore diploid. The sheltering of recessive mutations on the X/Z by the Y/W homolog is expected to drive slower adaptation for diploid X/Z loci, i.e. a reduction in the efficacy of selection. While the Faster-X effect has been studied extensively, much less is known empirically about the evolutionary dynamics of diploid X or Z chromosomes. Here, we took advantage of published population genomic data in the female-heterogametic human parasite Schistosoma japonicum to characterize the gene content and diversity levels of the diploid and hemizygous regions of the Z chromosome. We used different metrics of selective pressures acting on genes to test for differences in the efficacy of selection in hemizygous and diploid Z regions, relative to autosomes. We found consistent patterns suggesting reduced Ne, and reduced efficacy of purifying selection, on both hemizygous and diploid Z regions. Moreover, relaxed selection was particularly pronounced for female-biased genes on the diploid Z, as predicted by recent theoretical work."}],"day":"01","date_created":"2025-03-09T23:01:27Z","file_date_updated":"2025-03-10T08:25:59Z","volume":17,"title":"Reduced efficacy of selection on a young Z chromosome region of schistosoma japonicum","related_material":{"link":[{"url":"https://git.ista.ac.at/amrnjava/schistosomes_slower_z","relation":"software"}],"record":[{"id":"18549","relation":"earlier_version","status":"public"}]},"language":[{"iso":"eng"}],"intvolume":"        17","acknowledgement":"The authors would like to thank three anonymous reviewers for comments and suggestions. We are also grateful to Christelle Fraïsse, Marwan Elkrewi, and Filip Ruzicka for the help in this project.","citation":{"ista":"Mrnjavac A, Vicoso B. 2025. Reduced efficacy of selection on a young Z chromosome region of schistosoma japonicum. Genome Biology and Evolution. 17(2), evaf021.","chicago":"Mrnjavac, Andrea, and Beatriz Vicoso. “Reduced Efficacy of Selection on a Young Z Chromosome Region of Schistosoma Japonicum.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2025. <a href=\"https://doi.org/10.1093/gbe/evaf021\">https://doi.org/10.1093/gbe/evaf021</a>.","short":"A. Mrnjavac, B. Vicoso, Genome Biology and Evolution 17 (2025).","mla":"Mrnjavac, Andrea, and Beatriz Vicoso. “Reduced Efficacy of Selection on a Young Z Chromosome Region of Schistosoma Japonicum.” <i>Genome Biology and Evolution</i>, vol. 17, no. 2, evaf021, Oxford University Press, 2025, doi:<a href=\"https://doi.org/10.1093/gbe/evaf021\">10.1093/gbe/evaf021</a>.","ieee":"A. Mrnjavac and B. Vicoso, “Reduced efficacy of selection on a young Z chromosome region of schistosoma japonicum,” <i>Genome Biology and Evolution</i>, vol. 17, no. 2. Oxford University Press, 2025.","apa":"Mrnjavac, A., &#38; Vicoso, B. (2025). Reduced efficacy of selection on a young Z chromosome region of schistosoma japonicum. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evaf021\">https://doi.org/10.1093/gbe/evaf021</a>","ama":"Mrnjavac A, Vicoso B. Reduced efficacy of selection on a young Z chromosome region of schistosoma japonicum. <i>Genome Biology and Evolution</i>. 2025;17(2). doi:<a href=\"https://doi.org/10.1093/gbe/evaf021\">10.1093/gbe/evaf021</a>"},"ddc":["570"],"external_id":{"isi":["001423671400001"],"pmid":["39913672"]},"publication":"Genome Biology and Evolution","type":"journal_article","doi":"10.1093/gbe/evaf021","_id":"19370","author":[{"last_name":"Mrnjavac","id":"353FAC84-AE61-11E9-8BFC-00D3E5697425","full_name":"Mrnjavac, Andrea","first_name":"Andrea"},{"last_name":"Vicoso","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz"}],"quality_controlled":"1","publisher":"Oxford University Press","month":"02","article_type":"original","date_published":"2025-02-01T00:00:00Z","date_updated":"2025-09-30T10:49:17Z","publication_status":"published","department":[{"_id":"BeVi"}],"article_number":"evaf021","article_processing_charge":"Yes","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"gold","file":[{"date_updated":"2025-03-10T08:25:59Z","content_type":"application/pdf","access_level":"open_access","checksum":"e3aa993e3d6dad10cb806c243fa57408","file_size":768371,"creator":"dernst","success":1,"file_id":"19378","date_created":"2025-03-10T08:25:59Z","file_name":"2025_GBE_Mrnjavac.pdf","relation":"main_file"}],"oa_version":"Published Version","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","OA_place":"publisher","publication_identifier":{"eissn":["1759-6653"]},"corr_author":"1","has_accepted_license":"1","status":"public","issue":"2","year":"2025"},{"PlanS_conform":"1","article_type":"original","date_published":"2025-08-01T00:00:00Z","month":"08","publication_status":"published","date_updated":"2025-12-30T09:22:29Z","publisher":"Elsevier","oa":1,"department":[{"_id":"BeVi"}],"article_processing_charge":"Yes (via OA deal)","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","publication_identifier":{"issn":["0169-5347"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"hybrid","file":[{"file_id":"20905","relation":"main_file","file_name":"2025_TrendsEcoloEvolution_Vicoso.pdf","date_created":"2025-12-30T09:21:14Z","date_updated":"2025-12-30T09:21:14Z","success":1,"creator":"dernst","content_type":"application/pdf","file_size":699156,"checksum":"0a7c6e8600c878dac7082681e4409b50","access_level":"open_access"}],"oa_version":"Published Version","year":"2025","status":"public","issue":"8","corr_author":"1","has_accepted_license":"1","isi":1,"scopus_import":"1","file_date_updated":"2025-12-30T09:21:14Z","volume":40,"title":"Sex chromosome evolution in action in fourspine sticklebacks","language":[{"iso":"eng"}],"day":"01","abstract":[{"text":"The suppression of recombination between young X and Y chromosomes is a crucial step in their evolution, but why it occurs is not known. The detailed characterization of the polymorphic sex chromosomes of the fourspine stickleback by Liu et al. promises to shed new light on this longstanding question.","lang":"eng"}],"date_created":"2025-07-13T22:01:23Z","type":"journal_article","publication":"Trends in Ecology and Evolution","intvolume":"        40","acknowledgement":"I thank the Vicoso group for in-depth discussions of the original article highlighted here. This work was supported by an Austrian Research Fund (FWF) grant to B.V. (PAT 8748323).","citation":{"ista":"Vicoso B. 2025. Sex chromosome evolution in action in fourspine sticklebacks. Trends in Ecology and Evolution. 40(8), 728–730.","chicago":"Vicoso, Beatriz. “Sex Chromosome Evolution in Action in Fourspine Sticklebacks.” <i>Trends in Ecology and Evolution</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.tree.2025.06.010\">https://doi.org/10.1016/j.tree.2025.06.010</a>.","short":"B. Vicoso, Trends in Ecology and Evolution 40 (2025) 728–730.","ieee":"B. Vicoso, “Sex chromosome evolution in action in fourspine sticklebacks,” <i>Trends in Ecology and Evolution</i>, vol. 40, no. 8. Elsevier, pp. 728–730, 2025.","mla":"Vicoso, Beatriz. “Sex Chromosome Evolution in Action in Fourspine Sticklebacks.” <i>Trends in Ecology and Evolution</i>, vol. 40, no. 8, Elsevier, 2025, pp. 728–30, doi:<a href=\"https://doi.org/10.1016/j.tree.2025.06.010\">10.1016/j.tree.2025.06.010</a>.","apa":"Vicoso, B. (2025). Sex chromosome evolution in action in fourspine sticklebacks. <i>Trends in Ecology and Evolution</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tree.2025.06.010\">https://doi.org/10.1016/j.tree.2025.06.010</a>","ama":"Vicoso B. Sex chromosome evolution in action in fourspine sticklebacks. <i>Trends in Ecology and Evolution</i>. 2025;40(8):728-730. doi:<a href=\"https://doi.org/10.1016/j.tree.2025.06.010\">10.1016/j.tree.2025.06.010</a>"},"external_id":{"isi":["001550437400006"]},"ddc":["570"],"page":"728-730","author":[{"last_name":"Vicoso","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz"}],"quality_controlled":"1","project":[{"name":"Sex chromosomes in evolution and development","grant_number":"PAT 8748323","_id":"8ed82125-16d5-11f0-9cad-fbcae312235b"}],"doi":"10.1016/j.tree.2025.06.010","_id":"20009"},{"article_processing_charge":"Yes (via OA deal)","department":[{"_id":"BeVi"}],"article_number":"101411","oa":1,"publisher":"Elsevier","date_published":"2025-12-01T00:00:00Z","month":"12","article_type":"review","publication_status":"published","date_updated":"2025-12-30T13:14:38Z","PlanS_conform":"1","corr_author":"1","has_accepted_license":"1","status":"public","year":"2025","file":[{"success":1,"content_type":"application/pdf","file_size":897079,"access_level":"open_access","checksum":"262640abc34277686b56eb60102976f6","creator":"dernst","date_updated":"2025-12-30T13:14:20Z","relation":"main_file","date_created":"2025-12-30T13:14:20Z","file_name":"2025_CurrOpinionInsectScience_Toups.pdf","file_id":"20917"}],"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"hybrid","OA_place":"publisher","publication_identifier":{"issn":["2214-5745"],"eissn":["2214-5753"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"Sex chromosomes have evolved many times throughout the tree of life, and understanding what has shaped their unusual morphological, sequence, and regulatory features has been a long-standing goal. Most early insights into insect sex chromosome biology came from a few model species, such as the fruit fly Drosophila melanogaster, which limited broad-scale evolutionary inferences. More recently, extensive comparative genomics studies have uncovered several unexpected patterns, which we highlight in this review. First, we describe the conservation of the ancestral X chromosome over 450 million years but also its recurrent turnover (i.e. its reversal to an autosome when a new X chromosome arose) in at least one order. We then summarize classical and more recent findings on how insects modulate the expression of X-linked genes following the degradation of the Y chromosome and how the diverse mechanisms of dosage compensation identified may elucidate important principles of sex chromosome regulatory evolution.","lang":"eng"}],"day":"01","date_created":"2025-08-17T22:01:35Z","title":"Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation","language":[{"iso":"eng"}],"file_date_updated":"2025-12-30T13:14:20Z","volume":72,"scopus_import":"1","isi":1,"doi":"10.1016/j.cois.2025.101411","_id":"20182","project":[{"_id":"8ed82125-16d5-11f0-9cad-fbcae312235b","grant_number":"PAT 8748323","name":"Sex chromosomes in evolution and development"}],"quality_controlled":"1","author":[{"id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","first_name":"Melissa A","full_name":"Toups, Melissa A","last_name":"Toups","orcid":"0000-0002-9752-7380"},{"first_name":"Beatriz","full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","last_name":"Vicoso"}],"citation":{"ama":"Toups MA, Vicoso B. Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. <i>Current Opinion in Insect Science</i>. 2025;72. doi:<a href=\"https://doi.org/10.1016/j.cois.2025.101411\">10.1016/j.cois.2025.101411</a>","apa":"Toups, M. A., &#38; Vicoso, B. (2025). Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. <i>Current Opinion in Insect Science</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cois.2025.101411\">https://doi.org/10.1016/j.cois.2025.101411</a>","mla":"Toups, Melissa A., and Beatriz Vicoso. “Insect Sex Chromosome Evolution: Conservation, Turnover, and Mechanisms of Dosage Compensation.” <i>Current Opinion in Insect Science</i>, vol. 72, 101411, Elsevier, 2025, doi:<a href=\"https://doi.org/10.1016/j.cois.2025.101411\">10.1016/j.cois.2025.101411</a>.","ieee":"M. A. Toups and B. Vicoso, “Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation,” <i>Current Opinion in Insect Science</i>, vol. 72. Elsevier, 2025.","short":"M.A. Toups, B. Vicoso, Current Opinion in Insect Science 72 (2025).","chicago":"Toups, Melissa A, and Beatriz Vicoso. “Insect Sex Chromosome Evolution: Conservation, Turnover, and Mechanisms of Dosage Compensation.” <i>Current Opinion in Insect Science</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.cois.2025.101411\">https://doi.org/10.1016/j.cois.2025.101411</a>.","ista":"Toups MA, Vicoso B. 2025. Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. Current Opinion in Insect Science. 72, 101411."},"acknowledgement":"This work was supported by an Austrian Research Fund (FWF) grant to B.V. (PAT 8748323) and by the Louisiana Board of Regents Research Competitiveness Subprogram (LEQSF(2025-28)-RD-A-20) to MAT.","external_id":{"isi":["001582424100001"]},"ddc":["570"],"intvolume":"        72","type":"journal_article","publication":"Current Opinion in Insect Science"},{"intvolume":"        42","citation":{"apa":"Mrnjavac, A., Vicoso, B., &#38; Connallon, T. (2025). An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/molbev/msaf177\">https://doi.org/10.1093/molbev/msaf177</a>","ama":"Mrnjavac A, Vicoso B, Connallon T. An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content. <i>Molecular Biology and Evolution</i>. 2025;42(8). doi:<a href=\"https://doi.org/10.1093/molbev/msaf177\">10.1093/molbev/msaf177</a>","ieee":"A. Mrnjavac, B. Vicoso, and T. Connallon, “An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content,” <i>Molecular Biology and Evolution</i>, vol. 42, no. 8. Oxford University Press, 2025.","mla":"Mrnjavac, Andrea, et al. “An Extension of Muller’s Sheltering Hypothesis for the Evolution of Sex Chromosome Gene Content.” <i>Molecular Biology and Evolution</i>, vol. 42, no. 8, msaf177, Oxford University Press, 2025, doi:<a href=\"https://doi.org/10.1093/molbev/msaf177\">10.1093/molbev/msaf177</a>.","chicago":"Mrnjavac, Andrea, Beatriz Vicoso, and Tim Connallon. “An Extension of Muller’s Sheltering Hypothesis for the Evolution of Sex Chromosome Gene Content.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2025. <a href=\"https://doi.org/10.1093/molbev/msaf177\">https://doi.org/10.1093/molbev/msaf177</a>.","short":"A. Mrnjavac, B. Vicoso, T. Connallon, Molecular Biology and Evolution 42 (2025).","ista":"Mrnjavac A, Vicoso B, Connallon T. 2025. An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content. Molecular Biology and Evolution. 42(8), msaf177."},"acknowledgement":"We thank Filip Ruzicka, Colin Olito, Akane Uesugi, Melissa Toups, Daniel Jeffries, the Associate Editor, and anonymous reviewers, for comments and suggestions on earlier versions of the paper. We are particularly grateful to Deborah Charlesworth and Brian Charlesworth for extensive comments on two different drafts of the manuscript. We also thank Aneil Agrawal and Thomas Lenormand for email correspondence about the data on dominance and ways to interpret it. Technical support was provided by ISTA Scientific Computing Unit.","external_id":{"isi":["001547617100001"],"pmid":["40713898"]},"ddc":["570"],"publication":"Molecular Biology and Evolution","type":"journal_article","doi":"10.1093/molbev/msaf177","_id":"20223","author":[{"last_name":"Mrnjavac","id":"353FAC84-AE61-11E9-8BFC-00D3E5697425","first_name":"Andrea","full_name":"Mrnjavac, Andrea"},{"first_name":"Beatriz","full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","last_name":"Vicoso"},{"last_name":"Connallon","full_name":"Connallon, Tim","first_name":"Tim"}],"quality_controlled":"1","pmid":1,"isi":1,"scopus_import":"1","day":"01","abstract":[{"text":"The first influential hypothesis for sex chromosome evolution was proposed in 1914 by H. J. Muller, who argued that once recombination was suppressed between the X and Y chromosomes, Y-linked genes become “sheltered” from selection, leading to accumulation of recessive loss-of-function (LOF) mutations and decay of Y-linked genes. The hypothesis fell out of favor in the 1970s because early mathematical models failed to support it and data on the dominance of lethal mutations were viewed as incompatible with the hypothesis. We reevaluate the main arguments against Muller's hypothesis and find that they do not conclusively exclude a role for sheltering in sex chromosome evolution. By relaxing restrictive assumptions of earlier models, we show that sheltering promotes fixation of LOF mutations with sexually dimorphic fitness effects, resulting in decay of X-linked genes that are exclusively expressed by males and Y-linked genes that are primarily, though not necessarily exclusively, expressed by females. We further show that drift and other processes contributing to Y degeneration (i.e. selective interference and regulatory evolution) expand conditions of Y-linked gene loss by sheltering. The actual contribution of sheltering to sex chromosome evolution hinges upon the distribution of dominance and sex-specific fitness effects of LOF mutations, which we discuss.","lang":"eng"}],"date_created":"2025-08-24T22:01:31Z","file_date_updated":"2025-09-02T07:47:32Z","volume":42,"title":"An extension of Muller's sheltering hypothesis for the evolution of sex chromosome gene content","DOAJ_listed":"1","language":[{"iso":"eng"}],"related_material":{"link":[{"url":"https://git.ista.ac.at/bvicoso/xydegenerate","relation":"software"}]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"gold","file":[{"file_name":"2025_MolecularBioEvolution_Mrnjavac.pdf","date_created":"2025-09-02T07:47:32Z","relation":"main_file","file_id":"20274","creator":"dernst","file_size":1239841,"access_level":"open_access","checksum":"f40abffa56cb1e9ff65800f2a7d7b39a","content_type":"application/pdf","success":1,"date_updated":"2025-09-02T07:47:32Z"}],"oa_version":"Published Version","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","OA_place":"publisher","publication_identifier":{"issn":["0737-4038"],"eissn":["1537-1719"]},"has_accepted_license":"1","issue":"8","year":"2025","status":"public","publisher":"Oxford University Press","acknowledged_ssus":[{"_id":"ScienComp"}],"PlanS_conform":"1","month":"08","article_type":"original","date_published":"2025-08-01T00:00:00Z","date_updated":"2025-09-30T14:25:57Z","publication_status":"published","article_number":"msaf177","department":[{"_id":"BeVi"}],"article_processing_charge":"Yes","oa":1},{"file_date_updated":"2025-12-11T11:00:53Z","keyword":["Schizophora","sex chromosomes","sex-chromosome turnover","Diptera","genomic features","out-of-X movement."],"title":"Causes and consequences of sex-chromosome turnovers in Diptera","oa":1,"department":[{"_id":"BeVi"}],"abstract":[{"text":"Sex-chromosome systems are highly variable across animals, but how they transition from one to another is not well understood. Diptera have undergone multiple sex-chromosome turnovers and expansions while maintaining their general chromosomal content, which makes them an ideal clade to study such transitions. We analysed more than 100 dipteran whole-genome assemblies and identified 4 new lineages that underwent sex-chromosome turnover (in addition to the 5 previously reported). We find the majority of turnovers happened in the group Schizophora, which tend to have fewer genes on the F element (the chromosome homologous to the ancestral insect X chromosome) than lower dipterans, a factor previously hypothesized to facilitate turnover. Most derived X chromosomes have higher GC content than autosomes, consistent with a high prevalence of male-achiasmy in Diptera. In addition, an excess of gene movement out of the X is detected for most of these new X chromosomes, and many of these moved genes have high testis expression in Drosophila, suggesting that out-of-X gene movement contributes to the long-term demasculinization of X chromosomes.","lang":"eng"}],"article_processing_charge":"No","date_created":"2025-12-10T23:40:14Z","date_published":"2025-12-01T00:00:00Z","month":"12","date_updated":"2026-06-10T08:27:48Z","acknowledged_ssus":[{"_id":"ScienComp"}],"publisher":"Institute of Science and Technology Austria","year":"2025","author":[{"id":"02814589-eb8f-11eb-b029-a70074f3f18f","first_name":"Lorena Alexandra","full_name":"Layana Franco, Lorena Alexandra","last_name":"Layana Franco","orcid":"0000-0002-1253-6297"},{"first_name":"Melissa A","full_name":"Toups, Melissa A","id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9752-7380","last_name":"Toups"},{"last_name":"Vicoso","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","full_name":"Vicoso, Beatriz"}],"status":"public","has_accepted_license":"1","corr_author":"1","doi":"10.15479/AT-ISTA-20780","_id":"20780","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","type":"research_data","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"citation":{"short":"L.A. Layana Franco, M.A. Toups, B. Vicoso, (2025).","chicago":"Layana Franco, Lorena Alexandra, Melissa A Toups, and Beatriz Vicoso. “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20780\">https://doi.org/10.15479/AT-ISTA-20780</a>.","ista":"Layana Franco LA, Toups MA, Vicoso B. 2025. Causes and consequences of sex-chromosome turnovers in Diptera, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-20780\">10.15479/AT-ISTA-20780</a>.","ama":"Layana Franco LA, Toups MA, Vicoso B. Causes and consequences of sex-chromosome turnovers in Diptera. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20780\">10.15479/AT-ISTA-20780</a>","apa":"Layana Franco, L. A., Toups, M. A., &#38; Vicoso, B. (2025). Causes and consequences of sex-chromosome turnovers in Diptera. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20780\">https://doi.org/10.15479/AT-ISTA-20780</a>","mla":"Layana Franco, Lorena Alexandra, et al. <i>Causes and Consequences of Sex-Chromosome Turnovers in Diptera</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20780\">10.15479/AT-ISTA-20780</a>.","ieee":"L. A. Layana Franco, M. A. Toups, and B. Vicoso, “Causes and consequences of sex-chromosome turnovers in Diptera.” Institute of Science and Technology Austria, 2025."},"file":[{"date_updated":"2025-12-11T10:47:15Z","file_size":4575,"checksum":"251e7aab01917c2ad2fbccf465492ea1","access_level":"open_access","content_type":"application/zip","creator":"llayanaf","success":1,"file_id":"20799","date_created":"2025-12-11T10:47:15Z","file_name":"Perl_scripts.zip","relation":"main_file"},{"success":1,"access_level":"open_access","checksum":"daf1c03149dd170b14e5c8e109ee3c77","file_size":19052849,"content_type":"application/zip","creator":"llayanaf","date_updated":"2025-12-11T10:52:17Z","relation":"main_file","date_created":"2025-12-11T10:52:17Z","file_name":"Supplementary_Datasets.zip","file_id":"20800"},{"date_updated":"2025-12-11T10:52:11Z","checksum":"658d6e95a361b0a3db058b7b4e1733d4","access_level":"open_access","file_size":566476,"content_type":"application/zip","creator":"llayanaf","success":1,"file_id":"20801","date_created":"2025-12-11T10:52:11Z","file_name":"Supplementary_Tables.zip","relation":"main_file"},{"date_updated":"2025-12-11T11:00:53Z","creator":"llayanaf","file_size":1204,"checksum":"2a2b92eb9fade0015719190596a8c5b7","access_level":"open_access","content_type":"text/plain","success":1,"file_id":"20802","file_name":"README.txt","date_created":"2025-12-11T11:00:53Z","relation":"main_file"}],"oa_version":"Published Version"},{"type":"journal_article","publication":"Nature Communications","intvolume":"        16","citation":{"ista":"Paouneskou D, Baudrimont A, Kelemen RK, Elkrewi MN, Graf A, Moukbel Ali Aldawla S, Kölbl C, Tiemann-Boege I, Vicoso B, Jantsch V. 2025. BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity. Nature Communications. 16, 10446.","short":"D. Paouneskou, A. Baudrimont, R.K. Kelemen, M.N. Elkrewi, A. Graf, S. Moukbel Ali Aldawla, C. Kölbl, I. Tiemann-Boege, B. Vicoso, V. Jantsch, Nature Communications 16 (2025).","chicago":"Paouneskou, Dimitra, Antoine Baudrimont, Réka K Kelemen, Marwan N Elkrewi, Angela Graf, Shehab Moukbel Ali Aldawla, Claudia Kölbl, Irene Tiemann-Boege, Beatriz Vicoso, and Verena Jantsch. “BAF-1–VRK-1 Mediated Release of Meiotic Chromosomes from the Nuclear Periphery Is Important for Genome Integrity.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-65420-9\">https://doi.org/10.1038/s41467-025-65420-9</a>.","ieee":"D. Paouneskou <i>et al.</i>, “BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","mla":"Paouneskou, Dimitra, et al. “BAF-1–VRK-1 Mediated Release of Meiotic Chromosomes from the Nuclear Periphery Is Important for Genome Integrity.” <i>Nature Communications</i>, vol. 16, 10446, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-65420-9\">10.1038/s41467-025-65420-9</a>.","ama":"Paouneskou D, Baudrimont A, Kelemen RK, et al. BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-65420-9\">10.1038/s41467-025-65420-9</a>","apa":"Paouneskou, D., Baudrimont, A., Kelemen, R. K., Elkrewi, M. N., Graf, A., Moukbel Ali Aldawla, S., … Jantsch, V. (2025). BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-65420-9\">https://doi.org/10.1038/s41467-025-65420-9</a>"},"acknowledgement":"We are grateful to Monique Zetka, Nicola Silva, and Yumi Kim, Needhi Bhalla, George Krohne and Rueyling Lin for providing reagents; Scott Kennedy for sharing the multiplexed FISH library; and members of the Max Perutz Labs’ BioOptics facility (Irmgard Fischer, Josef Gotzmann, Thomas Peterbauer, Clara Bodner, and Nick Wedige) for training and support in image acquisition. We also thank the members of the NGS facility at the Vienna Biocenter. This work was funded by the Austrian Science Fund (FWF) SFB projects F 8805-B (VJ), https://doi.org/10.55776/F88, F 8809-B (ITB), and F8810-B (BV). We are also grateful to members of the V. Jantsch laboratory for helpful discussions. Some strains were provided by the Caenorhabditis Genetics Center, which is funded by the National Institutes of Health Office of Research Infrastructure Programs (P40OD010440).","external_id":{"pmid":["41290579"]},"ddc":["570"],"author":[{"last_name":"Paouneskou","full_name":"Paouneskou, Dimitra","first_name":"Dimitra"},{"first_name":"Antoine","full_name":"Baudrimont, Antoine","last_name":"Baudrimont"},{"orcid":"0000-0002-8489-9281","last_name":"Kelemen","full_name":"Kelemen, Réka K","first_name":"Réka K","id":"48D3F8DE-F248-11E8-B48F-1D18A9856A87"},{"id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","first_name":"Marwan N","full_name":"Elkrewi, Marwan N","last_name":"Elkrewi","orcid":"0000-0002-5328-7231"},{"last_name":"Graf","full_name":"Graf, Angela","first_name":"Angela"},{"last_name":"Moukbel Ali Aldawla","full_name":"Moukbel Ali Aldawla, Shehab","first_name":"Shehab"},{"full_name":"Kölbl, Claudia","first_name":"Claudia","last_name":"Kölbl"},{"full_name":"Tiemann-Boege, Irene","first_name":"Irene","last_name":"Tiemann-Boege"},{"orcid":"0000-0002-4579-8306","last_name":"Vicoso","full_name":"Vicoso, Beatriz","first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Jantsch","full_name":"Jantsch, Verena","first_name":"Verena"}],"quality_controlled":"1","project":[{"grant_number":"F8810","name":"The highjacking of meiosis for asexual reproduction","_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396"}],"doi":"10.1038/s41467-025-65420-9","_id":"20796","scopus_import":"1","pmid":1,"file_date_updated":"2025-12-15T09:25:51Z","volume":16,"title":"BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity","DOAJ_listed":"1","language":[{"iso":"eng"}],"day":"25","abstract":[{"text":"Rapid prophase chromosome movements ensure faithful alignment of the parental homologous chromosomes and successful synapsis formation during meiosis. These movements are driven by cytoplasmic forces transmitted to the nuclear periphery, where chromosome ends are attached through transmembrane proteins. During many developmental stages a specific genome architecture with chromatin nuclear periphery contacts mediates specific gene expression. Whether chromatin is removed from the nuclear periphery as a consequence of chromosome motions or by a specific mechanism is not fully understood. Here, we identify a mechanism to remove chromatin from the nuclear periphery through vaccinia related kinase (VRK-1)–dependent phosphorylation of Barrier to Autointegration Factor 1 (BAF-1) in Caenorhabditis elegans early prophase of meiosis. Interfering with chromatin removal delays chromosome pairing, impairs synapsis, produces oocytes with abnormal chromosomes and elevated apoptosis. Long read sequencing reveals deletions and duplications in offspring lacking VRK-1 underscoring the importance of the BAF-1–VRK-1 module in preserving genome stability in gametes during rapid chromosome movements.","lang":"eng"}],"date_created":"2025-12-11T10:45:06Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","publication_identifier":{"eissn":["2041-1723"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"gold","file":[{"checksum":"a952f7ea050242b79008540de49a0e61","content_type":"application/pdf","access_level":"open_access","file_size":8096309,"creator":"dernst","success":1,"date_updated":"2025-12-15T09:25:51Z","date_created":"2025-12-15T09:25:51Z","file_name":"2025_NatureComm_Paouneskou.pdf","relation":"main_file","file_id":"20823"}],"oa_version":"Published Version","status":"public","year":"2025","has_accepted_license":"1","PlanS_conform":"1","article_type":"original","date_published":"2025-11-25T00:00:00Z","month":"11","date_updated":"2025-12-15T09:28:37Z","publication_status":"published","publisher":"Springer Nature","oa":1,"department":[{"_id":"BeVi"}],"article_number":"10446","article_processing_charge":"Yes"},{"article_processing_charge":"Yes","department":[{"_id":"BeVi"},{"_id":"DaZi"}],"article_number":"msaf085","oa":1,"acknowledged_ssus":[{"_id":"ScienComp"}],"publisher":"Oxford University Press","month":"05","date_published":"2025-05-01T00:00:00Z","article_type":"original","date_updated":"2026-06-29T22:30:41Z","publication_status":"published","has_accepted_license":"1","corr_author":"1","status":"public","issue":"5","year":"2025","file":[{"file_id":"19756","relation":"main_file","file_name":"2025_MBE_Bett.pdf","date_created":"2025-05-28T09:34:36Z","date_updated":"2025-05-28T09:34:36Z","success":1,"creator":"dernst","file_size":1282772,"access_level":"open_access","checksum":"6c14b03f94b4aadf8869be2c4366d077","content_type":"application/pdf"}],"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"gold","OA_place":"publisher","publication_identifier":{"issn":["0737-4038"],"eissn":["1537-1719"]},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","abstract":[{"lang":"eng","text":"The males and females of the brine shrimp Artemia franciscana are highly dimorphic, and this dimorphism is associated with substantial sex-biased gene expression in heads and gonads. How these sex-specific patterns of expression are regulated at the molecular level is unknown. A. franciscana also has differentiated ZW sex chromosomes, with complete dosage compensation, but the molecular mechanism through which compensation is achieved is unknown. Here, we conducted CUT&TAG assays targeting 7 post-translational histone modifications (H3K27me3, H3K9me2, H3K9me3, H3K36me3, H3K27ac, H3K4me3, and H4K16ac) in heads and gonads of A. franciscana, allowing us to divide the genome into 12 chromatin states. We further defined functional chromatin signatures for all genes, which were correlated with transcript level abundances. Differences in the occupancy of the profiled epigenetic marks between sexes were associated with differential gene expression between males and females. Finally, we found a significant enrichment of the permissive H4K16ac histone mark in the Z-specific region in both tissues of females but not males, supporting the role of this histone mark in mediating dosage compensation of the Z chromosome."}],"day":"01","date_created":"2025-05-25T22:16:56Z","DOAJ_listed":"1","title":"Chromatin landscape is associated with sex-biased expression and Drosophila-like dosage compensation of the Z chromosome in Artemia franciscana","language":[{"iso":"eng"}],"related_material":{"link":[{"url":"https://github.com/vkb25/Chromatin-landscape-in-Artemia-franciscana.git","relation":"software"}],"record":[{"status":"public","id":"20449","relation":"dissertation_contains"},{"status":"deleted","id":"20444","relation":"dissertation_contains"}]},"file_date_updated":"2025-05-28T09:34:36Z","volume":42,"pmid":1,"scopus_import":"1","isi":1,"doi":"10.1093/molbev/msaf085","_id":"19735","project":[{"grant_number":"PAT 8748323","name":"Sex chromosomes in evolution and development","_id":"8ed82125-16d5-11f0-9cad-fbcae312235b"},{"_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396","name":"The highjacking of meiosis for asexual reproduction","grant_number":"F8810"}],"quality_controlled":"1","author":[{"last_name":"Bett","first_name":"Vincent K","full_name":"Bett, Vincent K","id":"57854184-AAE0-11E9-8D04-98D6E5697425"},{"full_name":"Trejo Arellano, Minerva S","first_name":"Minerva S","id":"2b681148-eed5-11eb-b81b-ae229e8620f8","orcid":"0000-0002-1982-3475","last_name":"Trejo Arellano"},{"last_name":"Vicoso","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","full_name":"Vicoso, Beatriz"}],"citation":{"ama":"Bett VK, Trejo Arellano MS, Vicoso B. Chromatin landscape is associated with sex-biased expression and Drosophila-like dosage compensation of the Z chromosome in Artemia franciscana. <i>Molecular Biology and Evolution</i>. 2025;42(5). doi:<a href=\"https://doi.org/10.1093/molbev/msaf085\">10.1093/molbev/msaf085</a>","apa":"Bett, V. K., Trejo Arellano, M. S., &#38; Vicoso, B. (2025). Chromatin landscape is associated with sex-biased expression and Drosophila-like dosage compensation of the Z chromosome in Artemia franciscana. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/molbev/msaf085\">https://doi.org/10.1093/molbev/msaf085</a>","ieee":"V. K. Bett, M. S. Trejo Arellano, and B. Vicoso, “Chromatin landscape is associated with sex-biased expression and Drosophila-like dosage compensation of the Z chromosome in Artemia franciscana,” <i>Molecular Biology and Evolution</i>, vol. 42, no. 5. Oxford University Press, 2025.","mla":"Bett, Vincent K., et al. “Chromatin Landscape Is Associated with Sex-Biased Expression and Drosophila-like Dosage Compensation of the Z Chromosome in Artemia Franciscana.” <i>Molecular Biology and Evolution</i>, vol. 42, no. 5, msaf085, Oxford University Press, 2025, doi:<a href=\"https://doi.org/10.1093/molbev/msaf085\">10.1093/molbev/msaf085</a>.","short":"V.K. Bett, M.S. Trejo Arellano, B. Vicoso, Molecular Biology and Evolution 42 (2025).","chicago":"Bett, Vincent K, Minerva S Trejo Arellano, and Beatriz Vicoso. “Chromatin Landscape Is Associated with Sex-Biased Expression and Drosophila-like Dosage Compensation of the Z Chromosome in Artemia Franciscana.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2025. <a href=\"https://doi.org/10.1093/molbev/msaf085\">https://doi.org/10.1093/molbev/msaf085</a>.","ista":"Bett VK, Trejo Arellano MS, Vicoso B. 2025. Chromatin landscape is associated with sex-biased expression and Drosophila-like dosage compensation of the Z chromosome in Artemia franciscana. Molecular Biology and Evolution. 42(5), msaf085."},"acknowledgement":"We thank the Vicoso lab for their help in maintaining Artemia and for their valuable feedback and suggestions. We thank Marwan Elkrewi for his useful technical advice and discussions. We are also grateful to the Scientific Unit at ISTA Austria for computational resources and assistance. This work was supported by Austrian science fund (FWF) grants PAT8748323 and SFB F88-10 (as part of the SFB Meiosis consortium https://sfbmeiosis.org) to BV and Swedish Research Council (Vetenskapsrådet, grant number 2020-06424) to MSTA.","ddc":["570"],"external_id":{"isi":["001483460200001"],"pmid":["40202086"]},"intvolume":"        42","type":"journal_article","publication":"Molecular Biology and Evolution"},{"article_number":"evae265","department":[{"_id":"BeVi"}],"article_processing_charge":"Yes","oa":1,"publisher":"Oxford University Press","acknowledged_ssus":[{"_id":"ScienComp"}],"date_updated":"2025-09-09T11:58:41Z","publication_status":"published","month":"12","date_published":"2024-12-01T00:00:00Z","article_type":"original","corr_author":"1","has_accepted_license":"1","issue":"12","status":"public","year":"2024","OA_type":"gold","tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"oa_version":"Published Version","file":[{"date_updated":"2025-01-08T08:28:07Z","content_type":"application/pdf","access_level":"open_access","checksum":"9cf8fd14580dd694dd810ccca808ad0e","file_size":795106,"creator":"dernst","success":1,"file_id":"18772","date_created":"2025-01-08T08:28:07Z","file_name":"2024_GBE_Fraser.pdf","relation":"main_file"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_identifier":{"eissn":["1759-6653"]},"OA_place":"publisher","date_created":"2025-01-05T23:01:58Z","day":"01","abstract":[{"lang":"eng","text":"Termites, together with cockroaches, belong to the Blattodea. They possess an XX/XY sex determination system which has evolved from an XX/X0 system present in other Blattodean species, such as cockroaches and wood roaches. Little is currently known about the sex chromosomes of termites, their gene content, or their evolution. We here investigate the X chromosome of multiple termite species and compare them with the X chromosome of cockroaches using genomic and transcriptomic data. We find that the X chromosome of the termite Macrotermes natalensis is large and differentiated showing hall marks of sex chromosome evolution such as dosage compensation, while this does not seem to be the case in the other two termite species investigated here where sex chromosomes may be evolutionary younger. Furthermore, the X chromosome in M. natalensis is different from the X chromosome found in the cockroach Blattella germanica indicating that sex chromosome turn-over events may have happened during termite evolution."}],"volume":16,"file_date_updated":"2025-01-08T08:28:07Z","language":[{"iso":"eng"}],"license":"https://creativecommons.org/licenses/by-nc/4.0/","title":"Evidence for a novel X chromosome in termites","DOAJ_listed":"1","pmid":1,"isi":1,"scopus_import":"1","project":[{"_id":"26641CAC-B435-11E9-9278-68D0E5697425","grant_number":"M02484","call_identifier":"FWF","name":"Sex Determination in Termites"}],"_id":"18761","doi":"10.1093/gbe/evae265","author":[{"last_name":"Fraser","full_name":"Fraser, Roxanne","first_name":"Roxanne"},{"full_name":"Moraa, Ruth","first_name":"Ruth","last_name":"Moraa"},{"last_name":"Djolai","first_name":"Annika","full_name":"Djolai, Annika"},{"full_name":"Meisenheimer, Nils","first_name":"Nils","last_name":"Meisenheimer"},{"last_name":"Laube","full_name":"Laube, Sophie","first_name":"Sophie"},{"first_name":"Beatriz","full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","last_name":"Vicoso"},{"first_name":"Ann K","full_name":"Huylmans, Ann K","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8871-4961","last_name":"Huylmans"}],"quality_controlled":"1","intvolume":"        16","ddc":["570"],"external_id":{"isi":["001380841100001"],"pmid":["39658246"]},"acknowledgement":"urthermore, we thank all lab members and collaborators for feedback on the project. Specifically, Dino McMahon provided R. flavipes males and females, Judith Korb provided C. secundus males and females, gave feedback on the project and discussed questions on termite reproduction, Mireille Vasseur-Cognet provided M. natalensis males and females, Ariana Macon performed the lab work for sequencing and the Vicoso group gave critical feedback on the project. We furthermore thank the HPC group at IST Austria and Christian Meesters at JGU Mainz for their technical support.\r\nThis work was supported by a Österreichischer Wissenschaftsfonds (FWF) grant of the Meitner Programme to A.K.H. (project number M 2484), funding by the Deutsche Forschungsgemeinschaft (DFG) of the Research Training Group GenEvo (project number 407023052) to A.K.H., R.F., and A.D., and funding of the DFG within the Schwerpunktprogramm Gevol to A.K.H. and R.M. (project number 503256468).","citation":{"chicago":"Fraser, Roxanne, Ruth Moraa, Annika Djolai, Nils Meisenheimer, Sophie Laube, Beatriz Vicoso, and Ann K Huylmans. “Evidence for a Novel X Chromosome in Termites.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/gbe/evae265\">https://doi.org/10.1093/gbe/evae265</a>.","short":"R. Fraser, R. Moraa, A. Djolai, N. Meisenheimer, S. Laube, B. Vicoso, A.K. Huylmans, Genome Biology and Evolution 16 (2024).","ista":"Fraser R, Moraa R, Djolai A, Meisenheimer N, Laube S, Vicoso B, Huylmans AK. 2024. Evidence for a novel X chromosome in termites. Genome Biology and Evolution. 16(12), evae265.","apa":"Fraser, R., Moraa, R., Djolai, A., Meisenheimer, N., Laube, S., Vicoso, B., &#38; Huylmans, A. K. (2024). Evidence for a novel X chromosome in termites. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evae265\">https://doi.org/10.1093/gbe/evae265</a>","ama":"Fraser R, Moraa R, Djolai A, et al. Evidence for a novel X chromosome in termites. <i>Genome Biology and Evolution</i>. 2024;16(12). doi:<a href=\"https://doi.org/10.1093/gbe/evae265\">10.1093/gbe/evae265</a>","mla":"Fraser, Roxanne, et al. “Evidence for a Novel X Chromosome in Termites.” <i>Genome Biology and Evolution</i>, vol. 16, no. 12, evae265, Oxford University Press, 2024, doi:<a href=\"https://doi.org/10.1093/gbe/evae265\">10.1093/gbe/evae265</a>.","ieee":"R. Fraser <i>et al.</i>, “Evidence for a novel X chromosome in termites,” <i>Genome Biology and Evolution</i>, vol. 16, no. 12. Oxford University Press, 2024."},"publication":"Genome Biology and Evolution","type":"journal_article"},{"date_updated":"2026-04-16T12:20:41Z","month":"08","date_published":"2024-08-05T00:00:00Z","publisher":"Institute of Science and Technology Austria","acknowledged_ssus":[{"_id":"ScienComp"}],"file_date_updated":"2024-08-05T23:28:52Z","related_material":{"record":[{"status":"public","id":"17890","relation":"used_in_publication"}]},"oa":1,"title":"Data for: \"Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome\"","department":[{"_id":"GradSch"},{"_id":"BeVi"}],"date_created":"2024-08-02T07:27:45Z","article_processing_charge":"No","abstract":[{"lang":"eng","text":"This is the supplementary data for the paper titled \"Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome\", where we described the generation and analysis of single-nucleus expression and chromatin-accessibility data from the female reproductive system of Artemia franciscana. We compared our dataset to the published Drosophila single-nucleus data (over 400 million years of divergence) and highlighted the extreme conservation of several of the molecular pathways of oogenesis and meiosis. We found evidence of global transcriptional quiescence and chromatin condensation in late germ cells, highlighting the conserved role of this repressive stage in arthropod oogenesis. Additionally, we explored the expression patterns of the ZW sex chromosomes during oogenesis. Our data shows that the Z-chromosome is consistently downregulated in germline cells. While this is partly driven by a lack of dosage compensation in the germline, a subset of cells show stronger repression of the Z chromosome."}],"day":"05","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"research_data","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"ddc":["576"],"oa_version":"Published Version","citation":{"mla":"Elkrewi, Marwan N., and Beatriz Vicoso. <i>Data for: “Single-Nucleus Atlas of the Artemia Female Reproductive System Suggests Germline Repression of the Z Chromosome.”</i> Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:17362\">10.15479/AT:ISTA:17362</a>.","ieee":"M. N. Elkrewi and B. Vicoso, “Data for: ‘Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome.’” Institute of Science and Technology Austria, 2024.","apa":"Elkrewi, M. N., &#38; Vicoso, B. (2024). Data for: “Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:17362\">https://doi.org/10.15479/AT:ISTA:17362</a>","ama":"Elkrewi MN, Vicoso B. Data for: “Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome.” 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:17362\">10.15479/AT:ISTA:17362</a>","ista":"Elkrewi MN, Vicoso B. 2024. Data for: ‘Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:17362\">10.15479/AT:ISTA:17362</a>.","chicago":"Elkrewi, Marwan N, and Beatriz Vicoso. “Data for: ‘Single-Nucleus Atlas of the Artemia Female Reproductive System Suggests Germline Repression of the Z Chromosome.’” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:17362\">https://doi.org/10.15479/AT:ISTA:17362</a>.","short":"M.N. Elkrewi, B. Vicoso, (2024)."},"file":[{"file_id":"17394","relation":"main_file","date_created":"2024-08-05T22:24:18Z","file_name":"README.txt","date_updated":"2024-08-05T22:24:18Z","success":1,"file_size":2465,"access_level":"open_access","checksum":"26b5d41b3103f4284dd97d56e370a5b6","content_type":"text/plain","creator":"melkrewi"},{"file_name":"Data_artemia_single_nucleus_atlas.zip","date_created":"2024-08-05T23:28:52Z","relation":"main_file","file_id":"17395","creator":"melkrewi","file_size":2526735400,"access_level":"open_access","content_type":"application/x-zip-compressed","checksum":"95adab5e36148015da313505e3910707","success":1,"date_updated":"2024-08-05T23:28:52Z"}],"status":"public","author":[{"id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","first_name":"Marwan N","full_name":"Elkrewi, Marwan N","last_name":"Elkrewi","orcid":"0000-0002-5328-7231"},{"last_name":"Vicoso","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz"}],"year":"2024","project":[{"_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396","grant_number":"F8810","name":"The highjacking of meiosis for asexual reproduction"}],"corr_author":"1","has_accepted_license":"1","_id":"17362","doi":"10.15479/AT:ISTA:17362"},{"volume":151,"file_date_updated":"2024-08-28T10:32:16Z","language":[{"iso":"eng"}],"title":"Compensation of gene dosage on the mammalian X","date_created":"2024-08-25T22:01:07Z","abstract":[{"lang":"eng","text":"Changes in gene dosage can have tremendous evolutionary potential (e.g. whole-genome duplications), but without compensatory mechanisms, they can also lead to gene dysregulation and pathologies. Sex chromosomes are a paradigmatic example of naturally occurring gene dosage differences and their compensation. In species with chromosome-based sex determination, individuals within the same population necessarily show ‘natural’ differences in gene dosage for the sex chromosomes. In this Review, we focus on the mammalian X chromosome and discuss recent new insights into the dosage-compensation mechanisms that evolved along with the emergence of sex chromosomes, namely X-inactivation and X-upregulation. We also discuss the evolution of the genetic loci and molecular players involved, as well as the regulatory diversity and potentially different requirements for dosage compensation across mammalian species."}],"day":"14","isi":1,"scopus_import":"1","pmid":1,"author":[{"last_name":"Cecalev","full_name":"Cecalev, Daniela","first_name":"Daniela"},{"full_name":"Vicoso, Beatriz","first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","last_name":"Vicoso"},{"full_name":"Galupa, Rafael","first_name":"Rafael","last_name":"Galupa"}],"quality_controlled":"1","_id":"17458","doi":"10.1242/dev.202891","type":"journal_article","publication":"Development","intvolume":"       151","ddc":["599"],"external_id":{"pmid":["39140247"],"isi":["001292608800003"]},"citation":{"ista":"Cecalev D, Vicoso B, Galupa R. 2024. Compensation of gene dosage on the mammalian X. Development. 151(15), dev202891.","short":"D. Cecalev, B. Vicoso, R. Galupa, Development 151 (2024).","chicago":"Cecalev, Daniela, Beatriz Vicoso, and Rafael Galupa. “Compensation of Gene Dosage on the Mammalian X.” <i>Development</i>. The Company of Biologists, 2024. <a href=\"https://doi.org/10.1242/dev.202891\">https://doi.org/10.1242/dev.202891</a>.","ieee":"D. Cecalev, B. Vicoso, and R. Galupa, “Compensation of gene dosage on the mammalian X,” <i>Development</i>, vol. 151, no. 15. The Company of Biologists, 2024.","mla":"Cecalev, Daniela, et al. “Compensation of Gene Dosage on the Mammalian X.” <i>Development</i>, vol. 151, no. 15, dev202891, The Company of Biologists, 2024, doi:<a href=\"https://doi.org/10.1242/dev.202891\">10.1242/dev.202891</a>.","ama":"Cecalev D, Vicoso B, Galupa R. Compensation of gene dosage on the mammalian X. <i>Development</i>. 2024;151(15). doi:<a href=\"https://doi.org/10.1242/dev.202891\">10.1242/dev.202891</a>","apa":"Cecalev, D., Vicoso, B., &#38; Galupa, R. (2024). Compensation of gene dosage on the mammalian X. <i>Development</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/dev.202891\">https://doi.org/10.1242/dev.202891</a>"},"acknowledgement":"We thank Estelle Nicolas for critical feedback on the manuscript and Ikuhiro Okamoto for critical feedback on the figures. We apologise to authors whose work we overlooked or did not discuss or cite due to limits in the number of references. We thank the anonymous reviewers for pointing us to additional literature and for their constructive feedback. Figures were prepared with BioRender.com. D.C. is supported by a fellowship from Ligue Contre le Cancer (LNCC_TAJT25850) and R.G. holds a tenured research position from the Centre National de la Recherche Scientifique (France). Research in the Galupa lab is supported by a grant from the Fondation pour la Recherche Médicale (AJE202305017142). Open Access funding provided by Fondation pour la Recherche Médicale. Deposited in PMC for immediate release.","oa":1,"department":[{"_id":"BeVi"}],"article_number":"dev202891","article_processing_charge":"Yes (in subscription journal)","date_updated":"2025-09-08T08:58:58Z","publication_status":"published","article_type":"original","date_published":"2024-08-14T00:00:00Z","month":"08","publisher":"The Company of Biologists","issue":"15","status":"public","year":"2024","has_accepted_license":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_identifier":{"issn":["0950-1991"],"eissn":["1477-9129"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","file":[{"file_id":"17464","relation":"main_file","file_name":"2024_Development_Cecalev.pdf","date_created":"2024-08-28T10:32:16Z","date_updated":"2024-08-28T10:32:16Z","success":1,"creator":"cchlebak","content_type":"application/pdf","file_size":2085135,"checksum":"5e428bda0440d3f957c694b315a8f2a9","access_level":"open_access"}]},{"publication":"bioRxiv","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"preprint","OA_place":"repository","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"citation":{"mla":"Mrnjavac, Andrea, and Beatriz Vicoso. “Evidence of a Slower-Z Effect in Schistosoma Japonicum.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2024.07.02.601697\">10.1101/2024.07.02.601697</a>.","ieee":"A. Mrnjavac and B. Vicoso, “Evidence of a Slower-Z effect in Schistosoma japonicum,” <i>bioRxiv</i>. .","ama":"Mrnjavac A, Vicoso B. Evidence of a Slower-Z effect in Schistosoma japonicum. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2024.07.02.601697\">10.1101/2024.07.02.601697</a>","apa":"Mrnjavac, A., &#38; Vicoso, B. (n.d.). Evidence of a Slower-Z effect in Schistosoma japonicum. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2024.07.02.601697\">https://doi.org/10.1101/2024.07.02.601697</a>","ista":"Mrnjavac A, Vicoso B. Evidence of a Slower-Z effect in Schistosoma japonicum. bioRxiv, <a href=\"https://doi.org/10.1101/2024.07.02.601697\">10.1101/2024.07.02.601697</a>.","short":"A. Mrnjavac, B. Vicoso, BioRxiv (n.d.).","chicago":"Mrnjavac, Andrea, and Beatriz Vicoso. “Evidence of a Slower-Z Effect in Schistosoma Japonicum.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2024.07.02.601697\">https://doi.org/10.1101/2024.07.02.601697</a>."},"oa_version":"Preprint","year":"2024","status":"public","author":[{"last_name":"Mrnjavac","full_name":"Mrnjavac, Andrea","first_name":"Andrea","id":"353FAC84-AE61-11E9-8BFC-00D3E5697425"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz","last_name":"Vicoso","orcid":"0000-0002-4579-8306"}],"corr_author":"1","doi":"10.1101/2024.07.02.601697","_id":"18549","month":"07","date_published":"2024-07-04T00:00:00Z","date_updated":"2026-06-29T22:30:24Z","publication_status":"draft","title":"Evidence of a Slower-Z effect in Schistosoma japonicum","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","related_material":{"record":[{"status":"public","relation":"later_version","id":"19370"},{"status":"public","relation":"dissertation_contains","id":"18531"}]},"oa":1,"main_file_link":[{"url":"https://doi.org/10.1101/2024.07.02.601697","open_access":"1"}],"language":[{"iso":"eng"}],"department":[{"_id":"BeVi"}],"article_processing_charge":"No","day":"04","abstract":[{"text":"Sex-linked and autosomal loci experience different selective pressures and\r\nevolutionary dynamics. X (or Z) chromosomes are often hemizygous, as Y (or W)\r\nchromosomes often degenerate. Such hemizygous regions can be under greater\r\nefficacy of selection, as recessive mutations are immediately exposed to selection in\r\nthe heterogametic sex (the so-called Faster-X or Faster-Z effect). However, in young\r\nnon-recombining regions, Y/W chromosomes often have many functional genes, and\r\nmany X/Z-linked loci are therefore diploid. The sheltering of recessive mutations on\r\nthe X/Z by the Y/W homolog is expected to drive a Slower-X (Slower-Z) effect for\r\ndiploid X/Z loci, i.e. a reduction in the efficacy of selection. While the Faster-X effect\r\nhas been studied extensively, much less is known empirically about the evolutionary\r\ndynamics of diploid X or Z chromosomes. Here, we took advantage of published\r\npopulation genomic data in the female-heterogametic human parasite Schistosoma\r\njaponicum to characterize the gene content and diversity levels of the diploid and\r\nhemizygous regions of the Z chromosome. We used different metrics of selective\r\npressures acting on genes to test for differences in the efficacy of selection in\r\nhemizygous and diploid Z regions, relative to autosomes. We found consistent\r\npatterns suggesting reduced Ne, and reduced efficacy of purifying selection, on both\r\nhemizygous and diploid Z regions. Moreover, relaxed selection was particularly\r\npronounced for female-biased genes on the diploid Z, as predicted by Slower-Z\r\ntheory.\r\n","lang":"eng"}],"date_created":"2024-11-13T09:12:08Z"},{"year":"2024","issue":"8","status":"public","has_accepted_license":"1","corr_author":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","OA_place":"publisher","publication_identifier":{"issn":["1553-7390"],"eissn":["1553-7404"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"OA_type":"gold","file":[{"date_updated":"2024-09-11T07:54:12Z","success":1,"access_level":"open_access","content_type":"application/pdf","file_size":8962687,"checksum":"f5d96b9af57126fc1063e951440477d6","creator":"dernst","file_id":"18056","relation":"main_file","date_created":"2024-09-11T07:54:12Z","file_name":"2024_PloSGenetics_Elkrewi.pdf"}],"oa_version":"Published Version","oa":1,"department":[{"_id":"BeVi"}],"article_number":"e1011376","article_processing_charge":"Yes","article_type":"original","date_published":"2024-08-30T00:00:00Z","month":"08","publication_status":"published","date_updated":"2026-06-29T22:30:29Z","APC_amount":"3145,39 EUR","publisher":"Public Library of Science","acknowledged_ssus":[{"_id":"ScienComp"}],"author":[{"last_name":"Elkrewi","orcid":"0000-0002-5328-7231","id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","first_name":"Marwan N","full_name":"Elkrewi, Marwan N"},{"full_name":"Vicoso, Beatriz","first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","last_name":"Vicoso"}],"quality_controlled":"1","project":[{"name":"FWF Open Access Fund","call_identifier":"FWF","_id":"3AC91DDA-15DF-11EA-824D-93A3E7B544D1"},{"name":"The highjacking of meiosis for asexual reproduction","grant_number":"F8810","_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396"}],"doi":"10.1371/journal.pgen.1011376","_id":"17890","publication":"PLoS Genetics","type":"journal_article","intvolume":"        20","acknowledgement":"We thank the Vicoso group for their valuable comments on the earlier draft of the manuscript. We would also like to thank the Vienna BioCenter Next Generation Sequencing (NGS) facility staff, and in particular, Thomas Grentzinger for his support with the handling and sequencing of the samples, the scientific computing unit at ISTA for the computational resources, Brittney Wick for the help with hosting our data on the UCSC Cell Browser, and Lora B. Sweeney for her valuable input at the different stages of the project.\r\nThis research was funded by the Austrian science fund (FWF), as part of the SFB Meiosis consortium https://sfbmeiosis.org/, grant ID FWF SFB F88-10) to BV. ","citation":{"ieee":"M. N. Elkrewi and B. Vicoso, “Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome,” <i>PLoS Genetics</i>, vol. 20, no. 8. Public Library of Science, 2024.","mla":"Elkrewi, Marwan N., and Beatriz Vicoso. “Single-Nucleus Atlas of the Artemia Female Reproductive System Suggests Germline Repression of the Z Chromosome.” <i>PLoS Genetics</i>, vol. 20, no. 8, e1011376, Public Library of Science, 2024, doi:<a href=\"https://doi.org/10.1371/journal.pgen.1011376\">10.1371/journal.pgen.1011376</a>.","apa":"Elkrewi, M. N., &#38; Vicoso, B. (2024). Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome. <i>PLoS Genetics</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pgen.1011376\">https://doi.org/10.1371/journal.pgen.1011376</a>","ama":"Elkrewi MN, Vicoso B. Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome. <i>PLoS Genetics</i>. 2024;20(8). doi:<a href=\"https://doi.org/10.1371/journal.pgen.1011376\">10.1371/journal.pgen.1011376</a>","ista":"Elkrewi MN, Vicoso B. 2024. Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome. PLoS Genetics. 20(8), e1011376.","chicago":"Elkrewi, Marwan N, and Beatriz Vicoso. “Single-Nucleus Atlas of the Artemia Female Reproductive System Suggests Germline Repression of the Z Chromosome.” <i>PLoS Genetics</i>. Public Library of Science, 2024. <a href=\"https://doi.org/10.1371/journal.pgen.1011376\">https://doi.org/10.1371/journal.pgen.1011376</a>.","short":"M.N. Elkrewi, B. Vicoso, PLoS Genetics 20 (2024)."},"ddc":["570"],"external_id":{"pmid":["39213449"],"isi":["001304090200001"]},"file_date_updated":"2024-09-11T07:54:12Z","volume":20,"DOAJ_listed":"1","title":"Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome","related_material":{"link":[{"relation":"software","url":"https://github.com/Melkrewi/Artemia-snRNAseq-Project"}],"record":[{"status":"public","id":"17362","relation":"research_data"},{"status":"public","id":"19386","relation":"dissertation_contains"}]},"language":[{"iso":"eng"}],"abstract":[{"text":"Our understanding of the molecular pathways that regulate oogenesis and define cellular identity in the Arthropod female reproductive system and the extent of their conservation is currently very limited. This is due to the focus on model systems, including Drosophila and Daphnia, which do not reflect the observed diversity of morphologies, reproductive modes, and sex chromosome systems. We use single-nucleus RNA and ATAC sequencing to produce a comprehensive single nucleus atlas of the adult Artemia franciscana female reproductive system. We map our data to the Fly Cell Atlas single-nucleus dataset of the Drosophila melanogaster ovary, shedding light on the conserved regulatory programs between the two distantly related Arthropod species. We identify the major cell types known to be present in the Artemia ovary, including germ cells, follicle cells, and ovarian muscle cells. Additionally, we use the germ cells to explore gene regulation and expression of the Z chromosome during meiosis, highlighting its unique regulatory dynamics and allowing us to explore the presence of meiotic sex chromosome silencing in this group.","lang":"eng"}],"day":"30","date_created":"2024-09-08T22:01:11Z","isi":1,"scopus_import":"1","pmid":1},{"pmid":1,"isi":1,"scopus_import":"1","date_created":"2024-02-18T23:01:02Z","abstract":[{"text":"Since the commercialization of brine shrimp (genus Artemia) in the 1950s, this lineage, and in particular the model species Artemia franciscana, has been the subject of extensive research. However, our understanding of the genetic mechanisms underlying various aspects of their reproductive biology, including sex determination, is still lacking. This is partly due to the scarcity of genomic resources for Artemia species and crustaceans in general. Here, we present a chromosome-level genome assembly of A. franciscana (Kellogg 1906), from the Great Salt Lake, United States. The genome is 1 GB, and the majority of the genome (81%) is scaffolded into 21 linkage groups using a previously published high-density linkage map. We performed coverage and FST analyses using male and female genomic and transcriptomic reads to quantify the extent of differentiation between the Z and W chromosomes. Additionally, we quantified the expression levels in male and female heads and gonads and found further evidence for dosage compensation in this species.","lang":"eng"}],"day":"20","volume":16,"file_date_updated":"2024-02-26T09:54:59Z","language":[{"iso":"eng"}],"related_material":{"record":[{"status":"public","relation":"research_data","id":"14705"},{"status":"public","id":"19386","relation":"dissertation_contains"},{"relation":"dissertation_contains","id":"20449","status":"public"},{"status":"deleted","relation":"dissertation_contains","id":"20444"}]},"DOAJ_listed":"1","title":"Chromosome-level assembly of Artemia franciscana sheds light on sex chromosome differentiation","intvolume":"        16","ddc":["570"],"external_id":{"pmid":["38245839"],"isi":["001153952800001"]},"citation":{"apa":"Bett, V. K., Macon, A., Vicoso, B., &#38; Elkrewi, M. N. (2024). Chromosome-level assembly of Artemia franciscana sheds light on sex chromosome differentiation. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evae006\">https://doi.org/10.1093/gbe/evae006</a>","ama":"Bett VK, Macon A, Vicoso B, Elkrewi MN. Chromosome-level assembly of Artemia franciscana sheds light on sex chromosome differentiation. <i>Genome Biology and Evolution</i>. 2024;16(1). doi:<a href=\"https://doi.org/10.1093/gbe/evae006\">10.1093/gbe/evae006</a>","mla":"Bett, Vincent K., et al. “Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex Chromosome Differentiation.” <i>Genome Biology and Evolution</i>, vol. 16, no. 1, evae006, Oxford University Press, 2024, doi:<a href=\"https://doi.org/10.1093/gbe/evae006\">10.1093/gbe/evae006</a>.","ieee":"V. K. Bett, A. Macon, B. Vicoso, and M. N. Elkrewi, “Chromosome-level assembly of Artemia franciscana sheds light on sex chromosome differentiation,” <i>Genome Biology and Evolution</i>, vol. 16, no. 1. Oxford University Press, 2024.","chicago":"Bett, Vincent K, Ariana Macon, Beatriz Vicoso, and Marwan N Elkrewi. “Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex Chromosome Differentiation.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/gbe/evae006\">https://doi.org/10.1093/gbe/evae006</a>.","short":"V.K. Bett, A. Macon, B. Vicoso, M.N. Elkrewi, Genome Biology and Evolution 16 (2024).","ista":"Bett VK, Macon A, Vicoso B, Elkrewi MN. 2024. Chromosome-level assembly of Artemia franciscana sheds light on sex chromosome differentiation. Genome Biology and Evolution. 16(1), evae006."},"type":"journal_article","publication":"Genome Biology and Evolution","_id":"15009","doi":"10.1093/gbe/evae006","author":[{"last_name":"Bett","id":"57854184-AAE0-11E9-8D04-98D6E5697425","full_name":"Bett, Vincent K","first_name":"Vincent K"},{"id":"2A0848E2-F248-11E8-B48F-1D18A9856A87","full_name":"Macon, Ariana","first_name":"Ariana","last_name":"Macon"},{"first_name":"Beatriz","full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","last_name":"Vicoso"},{"id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","first_name":"Marwan N","full_name":"Elkrewi, Marwan N","last_name":"Elkrewi","orcid":"0000-0002-5328-7231"}],"quality_controlled":"1","publisher":"Oxford University Press","publication_status":"published","date_updated":"2026-06-29T22:30:41Z","date_published":"2024-01-20T00:00:00Z","article_type":"original","month":"01","department":[{"_id":"BeVi"}],"article_number":"evae006","article_processing_charge":"Yes","oa":1,"OA_type":"gold","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","file":[{"file_id":"15029","relation":"main_file","date_created":"2024-02-26T09:54:59Z","file_name":"2024_GBE_Bett.pdf","date_updated":"2024-02-26T09:54:59Z","success":1,"content_type":"application/pdf","access_level":"open_access","file_size":5213306,"checksum":"106a40f10443b2e7ba66749844ebbdf1","creator":"dernst"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_identifier":{"eissn":["1759-6653"]},"OA_place":"publisher","corr_author":"1","has_accepted_license":"1","issue":"1","year":"2024","status":"public"},{"quality_controlled":"1","author":[{"id":"33AB266C-F248-11E8-B48F-1D18A9856A87","first_name":"Gemma","full_name":"Puixeu Sala, Gemma","last_name":"Puixeu Sala","orcid":"0000-0001-8330-1754"},{"full_name":"Macon, Ariana","first_name":"Ariana","id":"2A0848E2-F248-11E8-B48F-1D18A9856A87","last_name":"Macon"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","full_name":"Vicoso, Beatriz","last_name":"Vicoso","orcid":"0000-0002-4579-8306"}],"doi":"10.1093/g3journal/jkad121","_id":"14077","project":[{"call_identifier":"H2020","grant_number":"665385","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"},{"grant_number":"25817","name":"Sexual conflict: resolution, constraints and biomedical implications","_id":"9B9DFC9E-BA93-11EA-9121-9846C619BF3A"}],"publication":"G3: Genes, Genomes, Genetics","type":"journal_article","citation":{"apa":"Puixeu Sala, G., Macon, A., &#38; Vicoso, B. (2023). Sex-specific estimation of cis and trans regulation of gene expression in heads and gonads of Drosophila melanogaster. <i>G3: Genes, Genomes, Genetics</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/g3journal/jkad121\">https://doi.org/10.1093/g3journal/jkad121</a>","ama":"Puixeu Sala G, Macon A, Vicoso B. Sex-specific estimation of cis and trans regulation of gene expression in heads and gonads of Drosophila melanogaster. <i>G3: Genes, Genomes, Genetics</i>. 2023;13(8). doi:<a href=\"https://doi.org/10.1093/g3journal/jkad121\">10.1093/g3journal/jkad121</a>","mla":"Puixeu Sala, Gemma, et al. “Sex-Specific Estimation of Cis and Trans Regulation of Gene Expression in Heads and Gonads of Drosophila Melanogaster.” <i>G3: Genes, Genomes, Genetics</i>, vol. 13, no. 8, Oxford University Press, 2023, doi:<a href=\"https://doi.org/10.1093/g3journal/jkad121\">10.1093/g3journal/jkad121</a>.","ieee":"G. Puixeu Sala, A. Macon, and B. Vicoso, “Sex-specific estimation of cis and trans regulation of gene expression in heads and gonads of Drosophila melanogaster,” <i>G3: Genes, Genomes, Genetics</i>, vol. 13, no. 8. Oxford University Press, 2023.","chicago":"Puixeu Sala, Gemma, Ariana Macon, and Beatriz Vicoso. “Sex-Specific Estimation of Cis and Trans Regulation of Gene Expression in Heads and Gonads of Drosophila Melanogaster.” <i>G3: Genes, Genomes, Genetics</i>. Oxford University Press, 2023. <a href=\"https://doi.org/10.1093/g3journal/jkad121\">https://doi.org/10.1093/g3journal/jkad121</a>.","short":"G. Puixeu Sala, A. Macon, B. Vicoso, G3: Genes, Genomes, Genetics 13 (2023).","ista":"Puixeu Sala G, Macon A, Vicoso B. 2023. Sex-specific estimation of cis and trans regulation of gene expression in heads and gonads of Drosophila melanogaster. G3: Genes, Genomes, Genetics. 13(8)."},"acknowledgement":"We thank members of the Vicoso Group for comments on the manuscript, the Scientific Computing Unit at ISTA for technical support, and 2 anonymous reviewers for useful feedback. GP is the recipient of a DOC Fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria (DOC 25817) and received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant (agreement no. 665385).","ddc":["570"],"external_id":{"isi":["001002997200001"],"pmid":["37259621"]},"intvolume":"        13","title":"Sex-specific estimation of cis and trans regulation of gene expression in heads and gonads of Drosophila melanogaster","language":[{"iso":"eng"}],"related_material":{"record":[{"status":"public","relation":"research_data","id":"12933"},{"relation":"dissertation_contains","id":"14058","status":"public"}]},"file_date_updated":"2023-11-07T09:00:19Z","volume":13,"keyword":["Genetics (clinical)","Genetics","Molecular Biology"],"abstract":[{"text":"The regulatory architecture of gene expression is known to differ substantially between sexes in Drosophila, but most studies performed\r\nso far used whole-body data and only single crosses, which may have limited their scope to detect patterns that are robust across tissues\r\nand biological replicates. Here, we use allele-specific gene expression of parental and reciprocal hybrid crosses between 6 Drosophila\r\nmelanogaster inbred lines to quantify cis- and trans-regulatory variation in heads and gonads of both sexes separately across 3 replicate\r\ncrosses. Our results suggest that female and male heads, as well as ovaries, have a similar regulatory architecture. On the other hand,\r\ntestes display more and substantially different cis-regulatory effects, suggesting that sex differences in the regulatory architecture that\r\nhave been previously observed may largely derive from testis-specific effects. We also examine the difference in cis-regulatory variation\r\nof genes across different levels of sex bias in gonads and heads. Consistent with the idea that intersex correlations constrain expression\r\nand can lead to sexual antagonism, we find more cis variation in unbiased and moderately biased genes in heads. In ovaries, reduced cis\r\nvariation is observed for male-biased genes, suggesting that cis variants acting on these genes in males do not lead to changes in ovary\r\nexpression. Finally, we examine the dominance patterns of gene expression and find that sex- and tissue-specific patterns of inheritance\r\nas well as trans-regulatory variation are highly variable across biological crosses, although these were performed in highly controlled\r\nexperimental conditions. This highlights the importance of using various genetic backgrounds to infer generalizable patterns.","lang":"eng"}],"day":"01","date_created":"2023-08-18T06:52:14Z","scopus_import":"1","isi":1,"pmid":1,"year":"2023","issue":"8","status":"public","corr_author":"1","has_accepted_license":"1","publication_identifier":{"issn":["2160-1836"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"file_id":"14498","file_name":"2023_G3_Puixeu.pdf","date_created":"2023-11-07T09:00:19Z","relation":"main_file","date_updated":"2023-11-07T09:00:19Z","creator":"dernst","content_type":"application/pdf","checksum":"c62e29fc7c5efbf8356f4c60cab4a2d1","access_level":"open_access","file_size":845642,"success":1}],"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa":1,"article_processing_charge":"Yes","department":[{"_id":"BeVi"},{"_id":"NiBa"},{"_id":"GradSch"}],"article_type":"original","month":"08","date_published":"2023-08-01T00:00:00Z","publication_status":"published","date_updated":"2026-04-07T13:25:34Z","acknowledged_ssus":[{"_id":"ScienComp"}],"publisher":"Oxford University Press","ec_funded":1},{"pmid":1,"scopus_import":"1","isi":1,"date_created":"2023-11-26T23:00:54Z","abstract":[{"text":"Sex chromosomes have evolved independently multiple times, but why some are conserved for more than 100 million years whereas others turnover rapidly remains an open question. Here, we examine the homology of sex chromosomes across nine orders of insects, plus the outgroup springtails. We find that the X chromosome is likely homologous across insects and springtails; the only exception is in the Lepidoptera, which has lost the X and now has a ZZ/ZW sex-chromosome system. These results suggest the ancestral insect X chromosome has persisted for more than 450 million years—the oldest known sex chromosome to date. Further, we propose that the shrinking of gene content the dipteran X chromosome has allowed for a burst of sex-chromosome turnover that is absent from other speciose insect orders.","lang":"eng"}],"day":"02","related_material":{"link":[{"relation":"software","url":"https://git.ista.ac.at/bvicoso/veryoldx"}],"record":[{"id":"14616","relation":"research_data","status":"public"},{"status":"public","relation":"research_data","id":"14617"}]},"language":[{"iso":"eng"}],"title":"The X chromosome of insects likely predates the origin of class Insecta","volume":77,"file_date_updated":"2023-11-28T08:12:15Z","ddc":["570"],"external_id":{"pmid":["37738212"],"isi":["001170341900014"]},"acknowledgement":"All computational analyses were performed on the server at Institute of Science and Technology Austria. We thank Marwan Elkrewi and Vincent Bett for analytical advice, and Tanja Schwander and Vincent Merel for useful discussions. We also thank Matthew Hahn for comments on an earlier version of the manuscript.","citation":{"mla":"Toups, Melissa A., and Beatriz Vicoso. “The X Chromosome of Insects Likely Predates the Origin of Class Insecta.” <i>Evolution</i>, vol. 77, no. 11, Oxford University Press, 2023, pp. 2504–11, doi:<a href=\"https://doi.org/10.1093/evolut/qpad169\">10.1093/evolut/qpad169</a>.","ieee":"M. A. Toups and B. Vicoso, “The X chromosome of insects likely predates the origin of class Insecta,” <i>Evolution</i>, vol. 77, no. 11. Oxford University Press, pp. 2504–2511, 2023.","ama":"Toups MA, Vicoso B. The X chromosome of insects likely predates the origin of class Insecta. <i>Evolution</i>. 2023;77(11):2504-2511. doi:<a href=\"https://doi.org/10.1093/evolut/qpad169\">10.1093/evolut/qpad169</a>","apa":"Toups, M. A., &#38; Vicoso, B. (2023). The X chromosome of insects likely predates the origin of class Insecta. <i>Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/evolut/qpad169\">https://doi.org/10.1093/evolut/qpad169</a>","ista":"Toups MA, Vicoso B. 2023. The X chromosome of insects likely predates the origin of class Insecta. Evolution. 77(11), 2504–2511.","short":"M.A. Toups, B. Vicoso, Evolution 77 (2023) 2504–2511.","chicago":"Toups, Melissa A, and Beatriz Vicoso. “The X Chromosome of Insects Likely Predates the Origin of Class Insecta.” <i>Evolution</i>. Oxford University Press, 2023. <a href=\"https://doi.org/10.1093/evolut/qpad169\">https://doi.org/10.1093/evolut/qpad169</a>."},"intvolume":"        77","type":"journal_article","publication":"Evolution","_id":"14604","doi":"10.1093/evolut/qpad169","quality_controlled":"1","author":[{"full_name":"Toups, Melissa A","first_name":"Melissa A","id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9752-7380","last_name":"Toups"},{"full_name":"Vicoso, Beatriz","first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","last_name":"Vicoso"}],"page":"2504-2511","publisher":"Oxford University Press","publication_status":"published","date_updated":"2025-09-09T13:32:06Z","month":"11","date_published":"2023-11-02T00:00:00Z","article_type":"original","article_processing_charge":"Yes (in subscription journal)","department":[{"_id":"BeVi"}],"oa":1,"oa_version":"Published Version","file":[{"content_type":"application/pdf","access_level":"open_access","checksum":"b66dc10edae92d38918d534e64dda77c","file_size":1399102,"creator":"dernst","success":1,"date_updated":"2023-11-28T08:12:15Z","date_created":"2023-11-28T08:12:15Z","file_name":"2023_Evolution_Toups.pdf","relation":"main_file","file_id":"14618"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publication_identifier":{"eissn":["1558-5646"]},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","has_accepted_license":"1","year":"2023","status":"public","issue":"11"}]