[{"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publisher":"AAAS","scopus_import":"1","dataavailabilitystatement":" All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/or the Supplementary Materials and the associated data and code repositories. Source data underlying all figures and supplementary figures have been deposited in a Zenodo repository (DOi: 10.5281/zenodo.21718217) and will be made publicly available upon publication. custom simulation and analysis codes used in this study are available at https://codeocean.com/capsule/1237446/tree. no unique biological materials were generated in this study. Microfluidic mask designs generated for this work are available from the corresponding authors upon reasonable request.","fulldoi":"https://doi.org/10.1126/sciadv.aed0587","DOAJ_listed":"1","type":"journal_article","article_number":"eaed0587","volume":12,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"corr_author":"1","publication_status":"published","oa_version":"Published Version","file":[{"relation":"main_file","file_id":"23062","success":1,"file_size":11691064,"file_name":"2026_ScienceAdv_Dunajova.pdf","checksum":"79f419b659650a39b3dfa58c782690a8","creator":"dernst","access_level":"open_access","content_type":"application/pdf","date_updated":"2026-10-06T11:30:48Z","date_created":"2026-10-06T11:30:48Z"}],"doi":"10.1126/sciadv.aed0587","related_material":{"record":[{"relation":"earlier_version","status":"public","id":"21427"}]},"acknowledgement":"We thank all the members of the Hannezo and Sixt groups for fruitful discussions and t. Kato for advice on the experimental setup. We are also thankful for support from the Scientific Service Units (SSU) of IST Austria through resources provided by the imaging and Optics Facility (iOF) and the Lab Support Facility (lSF). We used chatGPt (GPt- 5,OpenAi, 2025) to make minor grammatical and stylistic revisions to the original manuscript, which was written by us. We carefully reviewed and verified all changes and are solely responsible for all scientific content, data, interpretation, and conclusions. Funding: Z.D. has received funding from the Doctoral Programme of the Austrian Academy of Sciences (OeAW):grant agreement 26360. this work was supported by the European Research council (grant ERC- SyG 101071793 to M.S.). E.S. and R.P.J. are supported by the Francis Crick Institute, which receives its core funding from cancer Research UK (cc2040), the UK Medical Research council(cc2040), and the Wellcome trust (cc2040) and the European Research council (ERC Advanced Grant cAn_ORGAniSe, grant agreement number 101019366).","quality_controlled":"1","article_processing_charge":"Yes","project":[{"name":"Motile active matter models of migrating cells and chiral filaments","grant_number":"26360","_id":"34d75525-11ca-11ed-8bc3-89b6307fee9d"},{"_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd","grant_number":"101071793","name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces"}],"researchdata_availability":"yes","publication":"Science Advances","abstract":[{"text":"Although studies of tumor invasion have mainly emphasized the evolution of genetic and epigenetic heterogeneity, cellular behaviors also depend on the physical microenvironment. Yet, the tumor microenvironment is both complex and continuously remodeled, making it hard to rigorously test its causal influence on tumor dissemination. Here, we adopted a reductionist approach to studying tumor cell invasion in microengineered environments of tunable patterned geometries. We find that not only the presence of obstacles but more unexpectedly their spatial disorder causes a drastic shift from a collective to a single-cell mode of invasion—comparable in strength to loss of cell-cell adhesion. Combining live-imaging and perturbation experiments with minimal biophysical modeling, we demonstrate that cell dissemination results both from local geometrical constraints and a global integration of spatial disorder over time. We identify generic universality classes of invasion dynamics dependent on environmental geometry, enabling us to identify quantitative physical principles for tumor dissemination.","lang":"eng"}],"article_type":"original","das_tickbox":"1","OA_place":"publisher","file_date_updated":"2026-10-06T11:30:48Z","supplementarymaterial":"no","publication_identifier":{"eissn":["2375-2548"]},"intvolume":"        12","date_updated":"2026-10-06T11:36:34Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["570"],"date_published":"2026-09-09T00:00:00Z","title":"Substrate heterogeneity promotes cancer cell dissemination through interface roughening","language":[{"iso":"eng"}],"_id":"22963","PlanS_conform":"1","day":"09","issue":"37","pmid":1,"status":"public","date_created":"2026-09-20T22:01:48Z","citation":{"ista":"Dunajova Z, Tasciyan S, Majek J, Merrin J, Jenkins RP, Sahai E, Sixt MK, Hannezo EB. 2026. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. Science Advances. 12(37), eaed0587.","chicago":"Dunajova, Zuzana, Saren Tasciyan, Juraj Majek, Jack Merrin, Robert P. Jenkins, Erik Sahai, Michael K Sixt, and Edouard B Hannezo. “Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening.” <i>Science Advances</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/sciadv.aed0587\">https://doi.org/10.1126/sciadv.aed0587</a>.","ieee":"Z. Dunajova <i>et al.</i>, “Substrate heterogeneity promotes cancer cell dissemination through interface roughening,” <i>Science Advances</i>, vol. 12, no. 37. AAAS, 2026.","ama":"Dunajova Z, Tasciyan S, Majek J, et al. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. <i>Science Advances</i>. 2026;12(37). doi:<a href=\"https://doi.org/10.1126/sciadv.aed0587\">10.1126/sciadv.aed0587</a>","short":"Z. Dunajova, S. Tasciyan, J. Majek, J. Merrin, R.P. Jenkins, E. Sahai, M.K. Sixt, E.B. Hannezo, Science Advances 12 (2026).","apa":"Dunajova, Z., Tasciyan, S., Majek, J., Merrin, J., Jenkins, R. P., Sahai, E., … Hannezo, E. B. (2026). Substrate heterogeneity promotes cancer cell dissemination through interface roughening. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.aed0587\">https://doi.org/10.1126/sciadv.aed0587</a>","mla":"Dunajova, Zuzana, et al. “Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening.” <i>Science Advances</i>, vol. 12, no. 37, eaed0587, AAAS, 2026, doi:<a href=\"https://doi.org/10.1126/sciadv.aed0587\">10.1126/sciadv.aed0587</a>."},"year":"2026","OA_type":"gold","department":[{"_id":"EdHa"},{"_id":"MiSi"},{"_id":"GradSch"},{"_id":"AnSa"},{"_id":"NanoFab"}],"external_id":{"pmid":["42715298"]},"month":"09","has_accepted_license":"1","oa":1,"author":[{"first_name":"Zuzana","last_name":"Dunajova","id":"4B39F286-F248-11E8-B48F-1D18A9856A87","full_name":"Dunajova, Zuzana"},{"orcid":"0000-0003-1671-393X","full_name":"Tasciyan, Saren","last_name":"Tasciyan","id":"4323B49C-F248-11E8-B48F-1D18A9856A87","first_name":"Saren"},{"first_name":"Juraj","last_name":"Majek","id":"3e6d9473-f38e-11ec-8ae0-c4e05a8aa9e1","full_name":"Majek, Juraj"},{"full_name":"Merrin, Jack","orcid":"0000-0001-5145-4609","id":"4515C308-F248-11E8-B48F-1D18A9856A87","last_name":"Merrin","first_name":"Jack"},{"full_name":"Jenkins, Robert P.","last_name":"Jenkins","first_name":"Robert P."},{"last_name":"Sahai","first_name":"Erik","full_name":"Sahai, Erik"},{"orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt"},{"first_name":"Edouard B","last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561"}]},{"department":[{"_id":"GradSch"},{"_id":"EdHa"}],"year":"2026","date_created":"2026-03-11T08:30:49Z","citation":{"mla":"Dunajova, Zuzana. <i>Geometry-Driven Self-Organization of Migrating Cells and Chiral Filaments</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21423\">10.15479/AT-ISTA-21423</a>.","ama":"Dunajova Z. Geometry-driven self-organization of migrating cells and chiral filaments. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21423\">10.15479/AT-ISTA-21423</a>","short":"Z. Dunajova, Geometry-Driven Self-Organization of Migrating Cells and Chiral Filaments, Institute of Science and Technology Austria, 2026.","apa":"Dunajova, Z. (2026). <i>Geometry-driven self-organization of migrating cells and chiral filaments</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21423\">https://doi.org/10.15479/AT-ISTA-21423</a>","chicago":"Dunajova, Zuzana. “Geometry-Driven Self-Organization of Migrating Cells and Chiral Filaments.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21423\">https://doi.org/10.15479/AT-ISTA-21423</a>.","ista":"Dunajova Z. 2026. Geometry-driven self-organization of migrating cells and chiral filaments. Institute of Science and Technology Austria.","ieee":"Z. Dunajova, “Geometry-driven self-organization of migrating cells and chiral filaments,” Institute of Science and Technology Austria, 2026."},"status":"public","author":[{"last_name":"Dunajova","id":"4B39F286-F248-11E8-B48F-1D18A9856A87","first_name":"Zuzana","full_name":"Dunajova, Zuzana"}],"degree_awarded":"PhD","has_accepted_license":"1","oa":1,"month":"03","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_published":"2026-03-11T00:00:00Z","date_updated":"2026-10-16T08:12:11Z","ddc":["539","570"],"publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-076-3"]},"file_date_updated":"2026-09-11T22:30:02Z","OA_place":"repository","day":"11","_id":"21423","language":[{"iso":"eng"}],"title":"Geometry-driven self-organization of migrating cells and chiral filaments","doi_confirm":"1","related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"13314"},{"status":"public","relation":"research_data","id":"13116"},{"status":"public","relation":"research_data","id":"21439"},{"status":"public","relation":"part_of_dissertation","id":"21427"}]},"acknowledgement":"Finally, I gratefully acknowledge funding from the DOC Fellowship of the Austrian Academy\r\nof Sciences (OeAW): grant agreement 26360.","supervisor":[{"orcid":"0000-0001-6005-1561","full_name":"Hannezo, Edouard B","last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","first_name":"Edouard B"}],"doi":"10.15479/AT-ISTA-21423","file":[{"relation":"main_file","file_id":"21446","checksum":"47ce6a48a0c63f28eca6e64c9ffd2c84","creator":"zdunajov","file_size":14662770,"file_name":"2026_Dunajova_Zuzana_Thesis_pdfA.pdf","access_level":"open_access","embargo":"2026-09-11","content_type":"application/pdf","date_updated":"2026-09-11T22:30:02Z","date_created":"2026-03-12T20:38:52Z"},{"embargo_to":"open_access","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","access_level":"closed","date_updated":"2026-09-11T22:30:02Z","date_created":"2026-03-12T20:40:18Z","relation":"source_file","checksum":"5dec5afdffd47c2b0b162d0fe1bed925","creator":"zdunajov","file_name":"Thesis-Dunajova_source_file.docx","file_size":32961408,"file_id":"21447"}],"abstract":[{"text":"Biological systems, such as cytoskeletal filaments and multicellular collectives, exhibit rich \r\nself-organization driven by their intrinsic activity and physical constraints. Across scales, \r\ngeometry plays a central role: the shape of active units and the structure of their environment \r\nstrongly influence how order emerges in these far-from-equilibrium systems. In this thesis, \r\nwe combine minimal active-matter models with bottom-up in vitro experiments to identify \r\nthe principles by which geometry and activity shape collective behavior in biological matter. \r\nAt the subcellular scale, we investigate how the physical properties of chiral FtsZ filaments \r\ngovern their large-scale organization. Using a mesoscopic model validated by reconstituted \r\nfilament assays, we show that filament shape, intrinsic curvature, and flexibility, together with \r\nactivity-driven straightening, determine whether filaments form chiral rings, polar bands, or \r\nnematic-like states. Our model shows that small changes in filament mechanics produce large \r\nshifts in collective structures, revealing how the geometry of individual filaments amplifies \r\nthrough activity to control patterns relevant for bacterial cytokinesis. \r\nAt the cellular scale, we examine how geometry of the external environment influences \r\ncollective cancer cell migration. Experiments in controlled microfabricated obstacle \r\nenvironments demonstrate that geometric disorder alone can induce a transition from \r\ncollective to single-cell invasion. A minimal model of active particles in disordered geometries \r\nreproduces these effects, demonstrating that cell dissemination results both from local \r\ngeometrical constraints and a global integration of spatial disorder over time. Surprisingly, \r\nthis transition is accompanied by a change in the universality class of interface dynamics, \r\nrevealing that cell-environment interactions can shift the collective behavior of an invasive \r\nfront purely through mechanics.  \r\nIn the last system, we study how cell-intrinsic geometry and chirality affect collective motion \r\nin confined and unconfined settings. Using a minimal model inspired by in vitro experiments, \r\nwe analyze motile cells that exhibit persistent rotation due to intrinsic left-right asymmetry. \r\nIn circular confinement, this simplified chiral model reproduces several experimentally \r\nobserved features within specific parameter regimes. At high densities in unconfined \r\nenvironments, however, intrinsic chirality becomes masked even before the onset of the \r\njamming transition. These results show that single-cell geometric asymmetry does not \r\nnecessarily translate into large-scale chiral flows, offering new insight into how forces and \r\nsymmetries shape collective motion in dense cellular systems. \r\nOverall, this work uncovers how geometric constraints – embedded in the intrinsic \r\narchitecture of an active filament or encoded in the complexity of a microenvironment \r\ncouple to active forces to generate different classes of complex behaviors. ","lang":"eng"}],"project":[{"_id":"34d75525-11ca-11ed-8bc3-89b6307fee9d","grant_number":"26360","name":"Motile active matter models of migrating cells and chiral filaments"}],"article_processing_charge":"No","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","type":"dissertation","fulldoi":"https://doi.org/10.15479/AT-ISTA-21423","publisher":"Institute of Science and Technology Austria","tmp":{"image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"oa_version":"Published Version","publication_status":"published","corr_author":"1","acknowledged_ssus":[{"_id":"ScienComp"}],"alternative_title":["ISTA Thesis"],"page":"110"},{"corr_author":"1","oa_version":"Published Version","acknowledged_ssus":[{"_id":"Bio"},{"_id":"ScienComp"}],"contributor":[{"first_name":"Saren","id":"4323B49C-F248-11E8-B48F-1D18A9856A87","last_name":"Tasciyan","contributor_type":"researcher","orcid":"0000-0003-1671-393X"},{"orcid":"0000-0001-9198-2182 ","contributor_type":"researcher","last_name":"Radler","id":"40136C2A-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp"}],"type":"research_data","fulldoi":"https://doi.org/10.15479/AT-ISTA-21439","publisher":"Institute of Science and Technology Austria","tmp":{"image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"project":[{"_id":"34d75525-11ca-11ed-8bc3-89b6307fee9d","grant_number":"26360","name":"Motile active matter models of migrating cells and chiral filaments"}],"abstract":[{"lang":"eng","text":"These files contain supplementary movies accompanying the PhD thesis “Geometry-driven self-organization of migrating cells and chiral filaments” by Zuzana Dunajova (2026). The videos provide additional visual material supporting the experiments and results described in the thesis."}],"article_processing_charge":"No","doi":"10.15479/AT-ISTA-21439","related_material":{"record":[{"id":"13314","relation":"used_in_publication","status":"public"},{"id":"21427","relation":"used_in_publication","status":"public"},{"status":"public","relation":"used_in_publication","id":"21423"}]},"file":[{"success":1,"file_id":"21440","file_name":"Supplementary_movies_Thesis_Dunajova.zip","creator":"zdunajov","checksum":"47809a9a31b748b16e21e92d11ddc87f","file_size":154465214,"relation":"main_file","date_updated":"2026-03-11T20:41:28Z","date_created":"2026-03-11T20:41:28Z","access_level":"open_access","content_type":"application/zip"},{"content_type":"text/plain","access_level":"open_access","date_updated":"2026-03-11T20:52:39Z","date_created":"2026-03-11T20:52:39Z","relation":"main_file","checksum":"a64a174bc6abf0a5e77631e4fd121f1f","creator":"zdunajov","file_name":"readme.txt","file_size":2289,"success":1,"file_id":"21441"}],"_id":"21439","day":"12","title":"Supplementary movies to PhD thesis “Geometry-driven self-organization of migrating cells and chiral filaments”","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","ddc":["570"],"date_updated":"2026-10-25T23:31:25Z","date_published":"2026-03-12T00:00:00Z","OA_place":"repository","file_date_updated":"2026-03-11T20:52:39Z","oa":1,"has_accepted_license":"1","author":[{"full_name":"Dunajova, Zuzana","first_name":"Zuzana","id":"4B39F286-F248-11E8-B48F-1D18A9856A87","last_name":"Dunajova"}],"month":"03","year":"2026","OA_type":"free access","citation":{"ama":"Dunajova Z. Supplementary movies to PhD thesis “Geometry-driven self-organization of migrating cells and chiral filaments.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21439\">10.15479/AT-ISTA-21439</a>","apa":"Dunajova, Z. (2026). Supplementary movies to PhD thesis “Geometry-driven self-organization of migrating cells and chiral filaments.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21439\">https://doi.org/10.15479/AT-ISTA-21439</a>","short":"Z. Dunajova, (2026).","mla":"Dunajova, Zuzana. <i>Supplementary Movies to PhD Thesis “Geometry-Driven Self-Organization of Migrating Cells and Chiral Filaments.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21439\">10.15479/AT-ISTA-21439</a>.","ista":"Dunajova Z. 2026. Supplementary movies to PhD thesis “Geometry-driven self-organization of migrating cells and chiral filaments”, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21439\">10.15479/AT-ISTA-21439</a>.","chicago":"Dunajova, Zuzana. “Supplementary Movies to PhD Thesis ‘Geometry-Driven Self-Organization of Migrating Cells and Chiral Filaments.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21439\">https://doi.org/10.15479/AT-ISTA-21439</a>.","ieee":"Z. Dunajova, “Supplementary movies to PhD thesis ‘Geometry-driven self-organization of migrating cells and chiral filaments.’” Institute of Science and Technology Austria, 2026."},"date_created":"2026-03-11T21:05:20Z","department":[{"_id":"GradSch"},{"_id":"EdHa"}],"status":"public"},{"status":"public","year":"2025","date_created":"2026-03-11T08:40:06Z","citation":{"chicago":"Dunajova, Zuzana, Saren Tasciyan, Juraj Majek, Jack Merrin, Erik Sahai, Michael K Sixt, and Edouard B Hannezo. “Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2025.05.20.655037\">https://doi.org/10.1101/2025.05.20.655037</a>.","ista":"Dunajova Z, Tasciyan S, Majek J, Merrin J, Sahai E, Sixt MK, Hannezo EB. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. bioRxiv, <a href=\"https://doi.org/10.1101/2025.05.20.655037\">10.1101/2025.05.20.655037</a>.","ieee":"Z. Dunajova <i>et al.</i>, “Substrate heterogeneity promotes cancer cell dissemination through interface roughening,” <i>bioRxiv</i>. .","mla":"Dunajova, Zuzana, et al. “Substrate Heterogeneity Promotes Cancer Cell Dissemination through Interface Roughening.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2025.05.20.655037\">10.1101/2025.05.20.655037</a>.","ama":"Dunajova Z, Tasciyan S, Majek J, et al. Substrate heterogeneity promotes cancer cell dissemination through interface roughening. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2025.05.20.655037\">10.1101/2025.05.20.655037</a>","apa":"Dunajova, Z., Tasciyan, S., Majek, J., Merrin, J., Sahai, E., Sixt, M. K., &#38; Hannezo, E. B. (n.d.). Substrate heterogeneity promotes cancer cell dissemination through interface roughening. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2025.05.20.655037\">https://doi.org/10.1101/2025.05.20.655037</a>","short":"Z. Dunajova, S. Tasciyan, J. Majek, J. Merrin, E. Sahai, M.K. Sixt, E.B. Hannezo, BioRxiv (n.d.)."},"department":[{"_id":"GradSch"},{"_id":"EdHa"},{"_id":"MiSi"},{"_id":"NanoFab"},{"_id":"AnSa"}],"month":"09","has_accepted_license":"1","oa":1,"author":[{"full_name":"Dunajova, Zuzana","last_name":"Dunajova","id":"4B39F286-F248-11E8-B48F-1D18A9856A87","first_name":"Zuzana"},{"orcid":"0000-0003-1671-393X","full_name":"Tasciyan, Saren","last_name":"Tasciyan","id":"4323B49C-F248-11E8-B48F-1D18A9856A87","first_name":"Saren"},{"first_name":"Juraj","last_name":"Majek","id":"3e6d9473-f38e-11ec-8ae0-c4e05a8aa9e1","full_name":"Majek, Juraj"},{"first_name":"Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87","last_name":"Merrin","full_name":"Merrin, Jack","orcid":"0000-0001-5145-4609"},{"first_name":"Erik","last_name":"Sahai","full_name":"Sahai, Erik"},{"first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","first_name":"Edouard B","orcid":"0000-0001-6005-1561","full_name":"Hannezo, Edouard B"}],"das_tickbox":"1","OA_place":"repository","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-10-25T23:31:25Z","date_published":"2025-09-25T00:00:00Z","ddc":["539","570"],"title":"Substrate heterogeneity promotes cancer cell dissemination through interface roughening","language":[{"iso":"eng"}],"_id":"21427","day":"25","doi":"10.1101/2025.05.20.655037","acknowledgement":"European Research Council, https://ror.org/0472cxd90, 101071793\r\nAustrian Academy of Sciences, 26360","related_material":{"record":[{"id":"21439","relation":"research_data","status":"public"},{"id":"22963","status":"public","relation":"later_version"},{"relation":"dissertation_contains","status":"public","id":"21423"}]},"article_processing_charge":"No","project":[{"_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd","grant_number":"101071793","name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces"},{"grant_number":"26360","name":"Motile active matter models of migrating cells and chiral filaments","_id":"34d75525-11ca-11ed-8bc3-89b6307fee9d"}],"publication":"bioRxiv","abstract":[{"text":"While tumor malignancy has been extensively studied under the prism of genetic and epigenetic heterogeneity, tumor cell states also critically depend on reciprocal interactions with the microenvironment. This raises the hitherto untested possibility that heterogeneity of the untransformed tumor stroma can actively fuel malignant progression. As biological heterogeneity is inherently difficult to control, we adopted a reductionist approach and let tumor cells invade micro-engineered environments harboring obstacles with precision-controlled geometry. We find that not only the presence of obstacles, but more surprisingly their spatial disorder, causes a drastic shift from a collective to a single-cell mode of invasion – comparable in strength to cadherin loss. Combining live-imaging and perturbation experiments with minimal biophysical modeling, we demonstrate that cell detachments result both from local geometrical constraints and a global integration of spatial disorder over time. We show that different types of microenvironments map onto different universality classes of invasion dynamics - homogeneous substrates follow Kardar–Parisi–Zhang (KPZ) scaling, while disordered ones exhibit exponents consistent with KPZ with quenched disorder (KPZq). Our findings highlight generic physical principles for how the mode of cancer cell invasion depends on environmental heterogeneity, with potential implications to understand tumor evolution in vivo.","lang":"eng"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"main_file_link":[{"url":"https://doi.org/10.1101/2025.05.20.655037","open_access":"1"}],"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","type":"preprint","fulldoi":"https://doi.org/10.1101/2025.05.20.655037","corr_author":"1","oa_version":"Preprint","publication_status":"draft"},{"date_created":"2023-06-02T12:30:40Z","citation":{"mla":"Dunajova, Zuzana, et al. <i>Chiral and Nematic Phases of Flexible Active Filaments</i>. Institute of Science and Technology Austria, 2023, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:13116\">10.15479/AT:ISTA:13116</a>.","ama":"Dunajova Z, Prats Mateu B, Radler P, et al. Chiral and nematic phases of flexible active filaments. 2023. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:13116\">10.15479/AT:ISTA:13116</a>","short":"Z. Dunajova, B. Prats Mateu, P. Radler, K. Lim, D. Brandis, P. Velicky, J.G. Danzl, R.W. Wong, J. Elgeti, E.B. Hannezo, M. Loose, (2023).","apa":"Dunajova, Z., Prats Mateu, B., Radler, P., Lim, K., Brandis, D., Velicky, P., … Loose, M. (2023). Chiral and nematic phases of flexible active filaments. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:13116\">https://doi.org/10.15479/AT:ISTA:13116</a>","ista":"Dunajova Z, Prats Mateu B, Radler P, Lim K, Brandis D, Velicky P, Danzl JG, Wong RW, Elgeti J, Hannezo EB, Loose M. 2023. Chiral and nematic phases of flexible active filaments, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:13116\">10.15479/AT:ISTA:13116</a>.","chicago":"Dunajova, Zuzana, Batirtze Prats Mateu, Philipp Radler, Keesiang Lim, Dörte Brandis, Philipp Velicky, Johann G Danzl, et al. “Chiral and Nematic Phases of Flexible Active Filaments.” Institute of Science and Technology Austria, 2023. <a href=\"https://doi.org/10.15479/AT:ISTA:13116\">https://doi.org/10.15479/AT:ISTA:13116</a>.","ieee":"Z. Dunajova <i>et al.</i>, “Chiral and nematic phases of flexible active filaments.” Institute of Science and Technology Austria, 2023."},"year":"2023","department":[{"_id":"MaLo"},{"_id":"EdHa"},{"_id":"JoDa"}],"status":"public","oa":1,"has_accepted_license":"1","author":[{"full_name":"Dunajova, Zuzana","first_name":"Zuzana","last_name":"Dunajova","id":"4B39F286-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Prats Mateu","id":"299FE892-F248-11E8-B48F-1D18A9856A87","first_name":"Batirtze","full_name":"Prats Mateu, Batirtze"},{"full_name":"Radler, Philipp","orcid":"0000-0001-9198-2182 ","last_name":"Radler","id":"40136C2A-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp"},{"full_name":"Lim, Keesiang","first_name":"Keesiang","last_name":"Lim"},{"last_name":"Brandis","first_name":"Dörte","full_name":"Brandis, Dörte"},{"last_name":"Velicky","id":"39BDC62C-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp","orcid":"0000-0002-2340-7431","full_name":"Velicky, Philipp"},{"full_name":"Danzl, Johann G","orcid":"0000-0001-8559-3973","first_name":"Johann G","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","last_name":"Danzl"},{"last_name":"Wong","first_name":"Richard W.","full_name":"Wong, Richard W."},{"full_name":"Elgeti, Jens","last_name":"Elgeti","first_name":"Jens"},{"orcid":"0000-0001-6005-1561","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","first_name":"Edouard B"},{"orcid":"0000-0001-7309-9724","full_name":"Loose, Martin","first_name":"Martin","last_name":"Loose","id":"462D4284-F248-11E8-B48F-1D18A9856A87"}],"month":"07","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["539"],"date_updated":"2026-10-25T23:31:25Z","date_published":"2023-07-26T00:00:00Z","file_date_updated":"2023-08-08T11:17:28Z","_id":"13116","day":"26","title":"Chiral and nematic phases of flexible active filaments","doi":"10.15479/AT:ISTA:13116","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"13314"},{"status":"public","relation":"used_in_publication","id":"21423"}]},"acknowledgement":"This work was supported by the European Research Council through grant ERC 2015-StG-679239 and by the Austrian Science Fund (FWF) StandAlone P34607 to M.L., B. P.M.  was also supported by the Kanazawa University WPI- NanoLSI Bio-SPM collaborative research program. Z.D. has received funding from Doctoral Programme of the Austrian Academy of Sciences (OeAW): Grant agreement 26360. We thank Jan Brugues (MPI CBG, Dresden, Germany), Andela Saric (ISTA, Klosterneuburg, Austria), Daniel Pearce (Uni Geneva, Switzerland) for valuable scientific input and comments on the manuscript. We are also thankful for the support by the Scientific Service Units (SSU) of IST Austria through resources provided by the Imaging and Optics Facility (IOF) and the Lab Support Facility (LSF). ","file":[{"relation":"main_file","file_id":"13983","success":1,"file_size":13111,"checksum":"4b4ec5d4df7672b3af5ba23b126b171b","creator":"pradler","file_name":"ReadMe File.docx","access_level":"open_access","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_updated":"2023-08-08T11:17:28Z","date_created":"2023-08-08T11:17:28Z"},{"success":1,"file_id":"13298","file_name":"TIRF_FtsZ WT 0.625µM.7z.001","file_size":1499504777,"checksum":"6f1673d6ae4f547cd49cfe7f87d9ab7e","creator":"pradler","relation":"main_file","date_updated":"2023-07-25T06:55:43Z","date_created":"2023-07-25T06:55:43Z","access_level":"open_access","content_type":"application/octet-stream"},{"date_updated":"2023-07-25T08:31:07Z","date_created":"2023-07-25T08:31:07Z","access_level":"open_access","content_type":"application/octet-stream","file_id":"13306","success":1,"creator":"pradler","file_name":"TIRF_FtsZ WT 0.900µM.7z.001","file_size":3986437211,"checksum":"bc0dea871af164f7419ac838a34a4162","relation":"main_file"},{"file_size":1292391225,"creator":"pradler","file_name":"TIRF_FtsZ WT 1.15µM.7z.001","checksum":"dde91b799364a8456ac463dcba7bf37d","file_id":"13299","success":1,"relation":"main_file","date_updated":"2023-07-25T06:56:54Z","date_created":"2023-07-25T06:56:54Z","content_type":"application/octet-stream","access_level":"open_access"},{"date_updated":"2023-07-25T08:25:07Z","date_created":"2023-07-25T08:25:07Z","access_level":"open_access","content_type":"application/octet-stream","success":1,"file_id":"13305","checksum":"ba59f4e3f062b378f45e579ec28898ce","file_size":4494279051,"file_name":"TIRF_FtsZ WT 1.25µM.7z.001","creator":"pradler","relation":"main_file"},{"relation":"main_file","checksum":"906e1fe2aaacd1a746c49ffe39bcca66","file_name":"TIRF_FtsZ WT 1.50µM.7z.001","creator":"pradler","file_size":4697620480,"file_id":"13303","success":1,"content_type":"application/octet-stream","access_level":"open_access","date_created":"2023-07-25T08:12:32Z","date_updated":"2023-07-25T08:12:32Z"},{"file_id":"13304","success":1,"creator":"pradler","file_size":3548897162,"checksum":"96e416494b129cb0139c8250246bfaff","file_name":"TIRF_FtsZ WT 1.50µM.7z.002","relation":"main_file","date_created":"2023-07-25T08:18:54Z","date_updated":"2023-07-25T08:18:54Z","access_level":"open_access","content_type":"application/octet-stream"},{"date_updated":"2023-07-25T06:59:59Z","date_created":"2023-07-25T06:59:59Z","access_level":"open_access","content_type":"application/octet-stream","success":1,"file_id":"13300","file_size":1472947913,"file_name":"TIRF_FtsZ WT 2.0µM.7z.001","creator":"pradler","checksum":"f1dfdee3d833cf8d2c6b3ecbbee566f3","relation":"main_file"},{"relation":"main_file","success":1,"file_id":"13301","checksum":"fe77296c7bfce8b95a67ecbbb07ced81","file_size":1993549431,"file_name":"TIRF_FtsZ WT 3.0µM.7z.001","creator":"pradler","access_level":"open_access","content_type":"application/octet-stream","date_created":"2023-07-25T07:05:40Z","date_updated":"2023-07-25T07:05:40Z"},{"checksum":"6bc6edb807f38b00528875b4e7070bbf","file_name":"TIRF_FtsZ WT 5.0µM.7z.001","file_size":1336984015,"creator":"pradler","file_id":"13302","success":1,"relation":"main_file","date_created":"2023-07-25T07:06:07Z","date_updated":"2023-07-25T07:06:07Z","content_type":"application/octet-stream","access_level":"open_access"},{"relation":"main_file","file_size":227620212,"file_name":"STED experiments.7z.001","checksum":"e46bbe73e90dc56e245ecda464930009","creator":"pradler","file_id":"13281","success":1,"content_type":"application/octet-stream","access_level":"open_access","date_updated":"2023-07-24T12:10:55Z","date_created":"2023-07-24T12:10:55Z"},{"relation":"main_file","file_size":3433349230,"creator":"pradler","checksum":"473aa9f1c097b8b03294b1f6d4f4aa04","file_name":"AFM_FtsZ WT.7z.001","success":1,"file_id":"13307","content_type":"application/octet-stream","access_level":"open_access","date_created":"2023-07-25T09:16:06Z","date_updated":"2023-07-25T09:16:06Z"},{"success":1,"file_id":"13282","checksum":"bc685a414d95bcd5bba4dcad0187e928","file_name":"TIRF_FtsZ WT and L169R intensity calibration.7z.001","file_size":1416013335,"creator":"pradler","relation":"main_file","date_created":"2023-07-24T12:11:54Z","date_updated":"2023-07-24T12:11:54Z","access_level":"open_access","content_type":"application/octet-stream"},{"checksum":"e6cac262a3cf5a6a45bf28edf1dac8cd","creator":"pradler","file_name":"TIRF_FtsZ L169R below 0.6µM.7z","file_size":2711456292,"file_id":"13285","success":1,"relation":"main_file","date_created":"2023-07-24T12:26:12Z","date_updated":"2023-07-24T12:26:12Z","content_type":"application/octet-stream","access_level":"open_access"},{"checksum":"755179b242a7a4ee03133a15c5eab4ce","creator":"pradler","file_name":"TIRF_FtsZ L169R 0.625µM.7z","file_size":2272169467,"file_id":"13296","success":1,"relation":"main_file","date_updated":"2023-07-24T19:19:25Z","date_created":"2023-07-24T19:19:25Z","content_type":"application/octet-stream","access_level":"open_access"},{"date_updated":"2023-07-24T13:02:04Z","date_created":"2023-07-24T13:02:04Z","content_type":"application/octet-stream","access_level":"open_access","file_size":2915542985,"creator":"pradler","file_name":"TIRF_FtsZ L169R 0.900µM.7z","checksum":"7179ce242938a688381d7126b9a7ec45","success":1,"file_id":"13287","relation":"main_file"},{"relation":"main_file","success":1,"file_id":"13294","file_name":"TIRF_FtsZ L169R 1.15µM.7z","checksum":"a808996cbca0f795e00de85f1922b497","creator":"pradler","file_size":2769959727,"access_level":"open_access","content_type":"application/octet-stream","date_updated":"2023-07-24T15:27:17Z","date_created":"2023-07-24T15:27:17Z"},{"content_type":"application/octet-stream","access_level":"open_access","date_created":"2023-07-24T19:22:29Z","date_updated":"2023-07-24T19:22:29Z","relation":"main_file","checksum":"9a42594d749e648a099fefd3e24108a8","file_size":4440142247,"file_name":"TIRF_FtsZ L169R 1.25uM.7z","creator":"pradler","success":1,"file_id":"13297"},{"relation":"main_file","success":1,"file_id":"13295","checksum":"d8df3e458dbdb83622ab4dd6c9313a4e","file_name":"TIRF_FtsZ L169R 1.50µM.7z","creator":"pradler","file_size":2727119370,"access_level":"open_access","content_type":"application/octet-stream","date_created":"2023-07-24T15:27:09Z","date_updated":"2023-07-24T15:27:09Z"},{"success":1,"file_id":"13283","file_name":"TIRF_FtsZ L169R 2.0µM.7z","creator":"pradler","checksum":"020db3ef1d1cbfb3cbe5bf49d6669849","file_size":1479677783,"relation":"main_file","date_created":"2023-07-24T12:12:41Z","date_updated":"2023-07-24T12:12:41Z","access_level":"open_access","content_type":"application/octet-stream"},{"date_updated":"2023-07-24T12:13:51Z","date_created":"2023-07-24T12:13:51Z","access_level":"open_access","content_type":"application/octet-stream","file_id":"13284","success":1,"creator":"pradler","file_name":"TIRF_FtsZ L169R 3.0µM.7z","checksum":"22f2aa112442fb767c0a58876d974ab0","file_size":1560846342,"relation":"main_file"},{"date_updated":"2023-07-25T09:12:45Z","date_created":"2023-07-25T09:12:45Z","content_type":"application/octet-stream","access_level":"open_access","checksum":"6fac58e020d7b30092945cb210100670","creator":"pradler","file_name":"AFM_FtsZ L169R.7z.001","file_size":2918160653,"success":1,"file_id":"13308","relation":"main_file"},{"date_created":"2023-08-03T19:50:52Z","date_updated":"2023-08-03T19:50:52Z","content_type":"text/csv","access_level":"open_access","creator":"mloose","file_size":77476061,"file_name":"EDFig4p_F5.csv","checksum":"3cdbf4a61857cb940439473c999bdfa6","file_id":"13947","success":1,"relation":"main_file"},{"relation":"main_file","file_id":"13948","success":1,"creator":"mloose","file_name":"EDFig4p_F40.csv","checksum":"a59d5b825b4fe830cdb8833b4851508d","file_size":74938608,"access_level":"open_access","content_type":"text/csv","date_updated":"2023-08-03T19:50:50Z","date_created":"2023-08-03T19:50:50Z"},{"date_updated":"2023-08-03T19:51:14Z","date_created":"2023-08-03T19:51:14Z","access_level":"open_access","content_type":"text/csv","file_id":"13949","success":1,"checksum":"fe40a48ed7708260557faa1e7e8687d4","file_name":"EDFig4p_F200.csv","creator":"mloose","file_size":81680327,"relation":"main_file"},{"relation":"main_file","creator":"mloose","file_size":169151538,"checksum":"30bebf102f03445445f3dd3c19209497","file_name":"Fig3a_4b_F40.csv","success":1,"file_id":"13950","content_type":"text/csv","access_level":"open_access","date_updated":"2023-08-03T19:51:45Z","date_created":"2023-08-03T19:51:45Z"},{"relation":"main_file","creator":"mloose","checksum":"29db5611c9e622710fbf7b1c83c621ec","file_size":94791496,"file_name":"Fig3a_F5.csv","success":1,"file_id":"13951","content_type":"text/csv","access_level":"open_access","date_updated":"2023-08-03T19:51:45Z","date_created":"2023-08-03T19:51:45Z"},{"access_level":"open_access","content_type":"text/csv","date_created":"2023-08-03T19:51:54Z","date_updated":"2023-08-03T19:51:54Z","relation":"main_file","success":1,"file_id":"13952","file_name":"Fig3a_F200.csv","creator":"mloose","checksum":"848456b4230c086e8999f57d57dba7f1","file_size":59166206}],"project":[{"name":"Self-Organization of the Bacterial Cell","grant_number":"679239","_id":"2595697A-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"_id":"fc38323b-9c52-11eb-aca3-ff8afb4a011d","grant_number":"P34607","name":"In vitro reconstitution of bacterial cell division"},{"name":"Motile active matter models of migrating cells and chiral filaments","grant_number":"26360","_id":"34d75525-11ca-11ed-8bc3-89b6307fee9d"}],"abstract":[{"text":"The emergence of large-scale order in self-organized systems relies on local interactions between individual components. During bacterial cell division, FtsZ -- a prokaryotic homologue of the eukaryotic protein tubulin -- polymerizes into treadmilling filaments that further organize into a cytoskeletal ring. In vitro, FtsZ filaments can form dynamic chiral assemblies. However, how the active and passive properties of individual filaments relate to these large-scale self-organized structures remains poorly understood. Here, we connect single filament properties with the mesoscopic scale by combining minimal active matter simulations and biochemical reconstitution experiments. We show that density and flexibility of active chiral filaments define their global order. At intermediate densities, curved, flexible filaments organize into chiral rings and polar bands. An effectively nematic organization dominates for high densities and for straight, mutant filaments with increased rigidity. Our predicted phase diagram captures these features quantitatively, demonstrating how the flexibility, density and chirality of active filaments affect their collective behaviour. Our findings shed light on the fundamental properties of active chiral matter and explain how treadmilling FtsZ filaments organize during bacterial cell division. ","lang":"eng"}],"article_processing_charge":"No","ec_funded":1,"fulldoi":"https://doi.org/10.15479/AT:ISTA:13116","type":"research_data","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publisher":"Institute of Science and Technology Austria","corr_author":"1","oa_version":"Published Version","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}]},{"quality_controlled":"1","article_processing_charge":"Yes (in subscription journal)","publication":"Nature Physics","project":[{"grant_number":"679239","name":"Self-Organization of the Bacterial Cell","_id":"2595697A-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"_id":"fc38323b-9c52-11eb-aca3-ff8afb4a011d","grant_number":"P34607","name":"In vitro reconstitution of bacterial cell division"},{"_id":"34d75525-11ca-11ed-8bc3-89b6307fee9d","grant_number":"26360","name":"Motile active matter models of migrating cells and chiral filaments"}],"abstract":[{"text":"The emergence of large-scale order in self-organized systems relies on local interactions between individual components. During bacterial cell division, FtsZ—a prokaryotic homologue of the eukaryotic protein tubulin—polymerizes into treadmilling filaments that further organize into a cytoskeletal ring. In vitro, FtsZ filaments can form dynamic chiral assemblies. However, how the active and passive properties of individual filaments relate to these large-scale self-organized structures remains poorly understood. Here we connect single-filament properties with the mesoscopic scale by combining minimal active matter simulations and biochemical reconstitution experiments. We show that the density and flexibility of active chiral filaments define their global order. At intermediate densities, curved, flexible filaments organize into chiral rings and polar bands. An effectively nematic organization dominates for high densities and for straight, mutant filaments with increased rigidity. Our predicted phase diagram quantitatively captures these features, demonstrating how the flexibility, density and chirality of the active filaments affect their collective behaviour. Our findings shed light on the fundamental properties of active chiral matter and explain how treadmilling FtsZ filaments organize during bacterial cell division.","lang":"eng"}],"article_type":"original","file":[{"date_created":"2024-01-30T14:28:30Z","date_updated":"2024-01-30T14:28:30Z","access_level":"open_access","content_type":"application/pdf","file_id":"14916","success":1,"checksum":"bc7673ca07d37309013a86166577b2f7","file_name":"2023_NaturePhysics_Dunajova.pdf","creator":"dernst","file_size":22471673,"relation":"main_file"}],"doi":"10.1038/s41567-023-02218-w","related_material":{"record":[{"status":"public","relation":"research_data","id":"13116"},{"id":"21439","relation":"research_data","status":"public"},{"id":"21423","relation":"dissertation_contains","status":"public"}]},"acknowledgement":"This work was supported by the European Research Council through grant ERC 2015-StG-679239 and by the Austrian Science Fund (FWF) StandAlone P34607 to M.L., B. P.M. was also supported by the Kanazawa University WPI- NanoLSI Bio-SPM collaborative research program. Z.D. has received funding from Doctoral Programme of the Austrian Academy of Sciences (OeAW): Grant agreement 26360. We thank Jan Brugues (MPI CBG, Dresden, Germany), Andela Saric (ISTA, Klosterneuburg, Austria), Daniel Pearce (Uni Geneva, Switzerland) for valuable scientific input and comments on the manuscript. We are also thankful for the support by the Scientific Service Units (SSU) of IST Austria through resources provided by the Imaging and Optics Facility (IOF) and the Lab Support Facility (LSF).","page":"1916-1926","volume":19,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"corr_author":"1","publication_status":"published","oa_version":"Published Version","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publisher":"Springer Nature","scopus_import":"1","ec_funded":1,"fulldoi":"https://doi.org/10.1038/s41567-023-02218-w","type":"journal_article","external_id":{"pmid":["38075437"],"isi":["001178645300041"]},"month":"12","oa":1,"has_accepted_license":"1","author":[{"full_name":"Dunajova, Zuzana","last_name":"Dunajova","id":"4B39F286-F248-11E8-B48F-1D18A9856A87","first_name":"Zuzana"},{"first_name":"Batirtze","id":"299FE892-F248-11E8-B48F-1D18A9856A87","last_name":"Prats Mateu","full_name":"Prats Mateu, Batirtze"},{"id":"40136C2A-F248-11E8-B48F-1D18A9856A87","last_name":"Radler","first_name":"Philipp","orcid":"0000-0001-9198-2182 ","full_name":"Radler, Philipp"},{"full_name":"Lim, Keesiang","last_name":"Lim","first_name":"Keesiang"},{"full_name":"Brandis, Dörte","first_name":"Dörte","last_name":"Brandis","id":"21d64d35-f128-11eb-9611-b8bcca7a12fd"},{"full_name":"Velicky, Philipp","orcid":"0000-0002-2340-7431","first_name":"Philipp","id":"39BDC62C-F248-11E8-B48F-1D18A9856A87","last_name":"Velicky"},{"first_name":"Johann G","last_name":"Danzl","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","full_name":"Danzl, Johann G","orcid":"0000-0001-8559-3973"},{"full_name":"Wong, Richard W.","last_name":"Wong","first_name":"Richard W."},{"last_name":"Elgeti","first_name":"Jens","full_name":"Elgeti, Jens"},{"orcid":"0000-0001-6005-1561","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","first_name":"Edouard B"},{"last_name":"Loose","id":"462D4284-F248-11E8-B48F-1D18A9856A87","first_name":"Martin","orcid":"0000-0001-7309-9724","full_name":"Loose, Martin"}],"status":"public","citation":{"mla":"Dunajova, Zuzana, et al. “Chiral and Nematic Phases of Flexible Active Filaments.” <i>Nature Physics</i>, vol. 19, Springer Nature, 2023, pp. 1916–26, doi:<a href=\"https://doi.org/10.1038/s41567-023-02218-w\">10.1038/s41567-023-02218-w</a>.","ama":"Dunajova Z, Prats Mateu B, Radler P, et al. Chiral and nematic phases of flexible active filaments. <i>Nature Physics</i>. 2023;19:1916-1926. doi:<a href=\"https://doi.org/10.1038/s41567-023-02218-w\">10.1038/s41567-023-02218-w</a>","apa":"Dunajova, Z., Prats Mateu, B., Radler, P., Lim, K., Brandis, D., Velicky, P., … Loose, M. (2023). Chiral and nematic phases of flexible active filaments. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-023-02218-w\">https://doi.org/10.1038/s41567-023-02218-w</a>","short":"Z. Dunajova, B. Prats Mateu, P. Radler, K. Lim, D. Brandis, P. Velicky, J.G. Danzl, R.W. Wong, J. Elgeti, E.B. Hannezo, M. Loose, Nature Physics 19 (2023) 1916–1926.","ista":"Dunajova Z, Prats Mateu B, Radler P, Lim K, Brandis D, Velicky P, Danzl JG, Wong RW, Elgeti J, Hannezo EB, Loose M. 2023. Chiral and nematic phases of flexible active filaments. Nature Physics. 19, 1916–1926.","chicago":"Dunajova, Zuzana, Batirtze Prats Mateu, Philipp Radler, Keesiang Lim, Dörte Brandis, Philipp Velicky, Johann G Danzl, et al. “Chiral and Nematic Phases of Flexible Active Filaments.” <i>Nature Physics</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41567-023-02218-w\">https://doi.org/10.1038/s41567-023-02218-w</a>.","ieee":"Z. Dunajova <i>et al.</i>, “Chiral and nematic phases of flexible active filaments,” <i>Nature Physics</i>, vol. 19. Springer Nature, pp. 1916–1926, 2023."},"date_created":"2023-07-27T14:44:45Z","year":"2023","department":[{"_id":"JoDa"},{"_id":"EdHa"},{"_id":"MaLo"},{"_id":"GradSch"}],"title":"Chiral and nematic phases of flexible active filaments","_id":"13314","language":[{"iso":"eng"}],"day":"01","pmid":1,"isi":1,"file_date_updated":"2024-01-30T14:28:30Z","intvolume":"        19","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"date_published":"2023-12-01T00:00:00Z","date_updated":"2026-10-25T23:31:25Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","ddc":["530"]}]